[ { "uniprot_canonical_ac": "P17809-1", "uniprot_id": "GTR1_MOUSE", "mass": 53985.0, "length": 492, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 1", "gene_name": "Slc2a1", "organism": "Mouse", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 1 isoform 1", "refseq_ac": "NP_035530", "gene_names_uniprotkb": "Slc2a1; Glut1", "gene_names_refseq": "GT1; Glut-1; Glut1; M100200; Rgsc200; Slc2a1", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 1; GLUT-1; GT1; Glucose transporter type 1, erythrocyte/brain", "protein_names_refseq": "glucose transporter type 1, erythrocyte/brain; solute carrier family 2, facilitated glucose transporter member 1 isoform 1; solute carrier family 2, member 1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); myelomeningocele (Disease Ontology:DOID:0060326); glucose transporter type 1 deficiency syndrome (Disease Ontology:DOID:0070560); glucose transporter type 1 deficiency syndrome 1 (Disease Ontology:DOID:0070561); dystonia 9 (Disease Ontology:DOID:0090044); glucose transporter type 1 deficiency syndrome 2 (Disease Ontology:DOID:0090045); Hirschsprung's disease (Disease Ontology:DOID:10487); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypothyroidism (Disease Ontology:DOID:1459); childhood absence epilepsy (Disease Ontology:DOID:1825); nephroblastoma (Disease Ontology:DOID:2154); hemangioma (Disease Ontology:DOID:255); middle cerebral artery infarction (Disease Ontology:DOID:3525); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20525); (R-MMU-189200); (R-MMU-196836); (R-MMU-422356); (R-MMU-5653890)", "pathway_count": 5, "publication_count": 22, "publication_id_list": "1289053;1339457;14578187;17320047;1765007;19349973;19656770;21750661;2190533;23776597;25957687;26495903;2654938;26740625;27802388;28011936;30197081;31219806;31767175;33300544;35810171;37828378", "class_list": "glycogene", "function": "Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:17320047, PubMed:35810171). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (PubMed:35810171)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 18, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61608;Q6GTI3", "ec_number_list": "", "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0042802 identical protein binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0001666 response to hypoxia;GO:0021987 cerebral cortex development;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P17809-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0J8-1", "uniprot_id": "GNTK_MOUSE", "mass": 19981.0, "length": 184, "protein_name": "Gluconokinase", "gene_name": "Idnk", "organism": "Mouse", "refseq_name": "probable gluconokinase isoform a", "refseq_ac": "NP_932121", "gene_names_uniprotkb": "Idnk; 5133401N09Rik", "gene_names_refseq": "5133401N09Rik; Idnk", "protein_names_uniprotkb": "Gluconokinase; 2.7.1.12; Gluconate kinase", "protein_names_refseq": "gluconate kinase; probable gluconokinase isoform a; probable gluconokinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:75731)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "Phosphorylates gluconate to 6-phosphogluconate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.12", "go_molecular_function": "GO:0046316 gluconokinase activity;GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R0J8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UFS4-1", "uniprot_id": "GPT11_MOUSE", "mass": 30608.0, "length": 262, "protein_name": "G patch domain-containing protein 11", "gene_name": "Gpatch11", "organism": "Mouse", "refseq_name": "G patch domain-containing protein 11", "refseq_ac": "NP_857632", "gene_names_uniprotkb": "Gpatch11; Ccdc75", "gene_names_refseq": "2310002B06Rik; Ccdc75; Gpatch11", "protein_names_uniprotkb": "G patch domain-containing protein 11; Coiled-coil domain-containing protein 75", "protein_names_refseq": "G patch domain-containing protein 11; coiled-coil domain containing 75; coiled-coil domain-containing protein 75", "tax_id": 10090, "disease": "", "pathway": " (mmu:53951)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;27669760", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B9EHQ5;Q05BG4;Q569F3", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0000776 kinetochore;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UFS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P6I6-1", "uniprot_id": "GRL1A_MOUSE", "mass": 41237.0, "length": 366, "protein_name": "DNA-directed RNA polymerase II subunit GRINL1A", "gene_name": "Polr2m", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase II subunit GRINL1A isoform 2", "refseq_ac": "NP_001158265", "gene_names_uniprotkb": "Polr2m; Grinl1a", "gene_names_refseq": "D9Wsu138e; Grinl1a; Polr2m; mKIAA4185", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit GRINL1A; DNA-directed RNA polymerase II subunit M; Glutamate receptor-like protein 1A", "protein_names_refseq": "DNA-directed RNA polymerase II subunit GRINL1A isoform 2; DNA-directed RNA polymerase II subunit GRINL1A; DNA-directed RNA polymerase II subunit M; glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A; glutamate receptor-like protein 1A; protein GRINL1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:28015)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12063408;21750661;32381628;34741119;37507081", "class_list": "", "function": "Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II., [UniProtKB, UniProtKB]; The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis., [RefSeq, PubMed]; Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CG13;Q9CXJ7;Q9DCQ9", "ec_number_list": "", "go_molecular_function": "GO:0000993 RNA polymerase II complex binding;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0043025 neuronal cell body;GO:0031674 I band", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0051685 maintenance of ER location", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6P6I6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14427-1", "uniprot_id": "HA14_MOUSE", "mass": 41342.0, "length": 368, "protein_name": "H-2 class I histocompatibility antigen, D-P alpha chain", "gene_name": "H2-D1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H2-D1", "gene_names_refseq": "", "protein_names_uniprotkb": "H-2 class I histocompatibility antigen, D-P alpha chain; H-2D(P)", "protein_names_refseq": "", "tax_id": 10090, "disease": "Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); colitis (Disease Ontology:DOID:0060180); Cytomegalovirus retinitis (Disease Ontology:DOID:0080160); COVID-19 (Disease Ontology:DOID:0080600); ankylosing spondylitis 1 (Disease Ontology:DOID:0080603); erythema nodosum (Disease Ontology:DOID:0080750); occupational asthma (Disease Ontology:DOID:0080820); birdshot chorioretinopathy (Disease Ontology:DOID:0111079); psoriasis 1 (Disease Ontology:DOID:0111286); sensorineural hearing loss (Disease Ontology:DOID:10003); pre-eclampsia (Disease Ontology:DOID:10591); spondyloarthropathy (Disease Ontology:DOID:1123); trachoma (Disease Ontology:DOID:11265); sarcoidosis (Disease Ontology:DOID:11335); retinal vasculitis (Disease Ontology:DOID:11563); otosclerosis (Disease Ontology:DOID:12185); Graves' disease (Disease Ontology:DOID:12361); vulva cancer (Disease Ontology:DOID:1245); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); thromboangiitis obliterans (Disease Ontology:DOID:12918); retinopathy of prematurity (Disease Ontology:DOID:13025); Moyamoya disease (Disease Ontology:DOID:13099); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); anterior uveitis (Disease Ontology:DOID:1407); cystic fibrosis (Disease Ontology:DOID:1485); Melkersson-Rosenthal syndrome (Disease Ontology:DOID:1761); hepatitis C (Disease Ontology:DOID:1883); Takayasu's arteritis (Disease Ontology:DOID:2508); synovitis (Disease Ontology:DOID:2703); dermatitis (Disease Ontology:DOID:2723); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); cerebral infarction (Disease Ontology:DOID:3526); acute retinal necrosis syndrome (Disease Ontology:DOID:3611); thrombophlebitis (Disease Ontology:DOID:3875); tuberculosis (Disease Ontology:DOID:399); scleroderma (Disease Ontology:DOID:419); cervical cancer (Disease Ontology:DOID:4362); allergic rhinitis (Disease Ontology:DOID:4481); central nervous system vasculitis (Disease Ontology:DOID:525); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); uveal melanoma (Disease Ontology:DOID:6039); reactive arthritis (Disease Ontology:DOID:6196); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); ankylosing spondylitis (Disease Ontology:DOID:7147); diabetic retinopathy (Disease Ontology:DOID:8947); allergic asthma (Disease Ontology:DOID:9415); Meniere's disease (Disease Ontology:DOID:9849); alopecia (Disease Ontology:DOID:987); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (mmu:14964)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10.1101/2023.09.13.557529;10993729;11672544;17502423;19144319;19531064;19656770;19951915;21750661;2903482;29187734;3082989;3680952;3856254;3925012;3980466;6318117;6571712;6895103;7118211;7118212;7225204;7295646;7506996;9729040;9869916", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 51, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0046978 TAP1 binding;GO:0046979 TAP2 binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0030670 phagocytic vesicle membrane;GO:0042612 MHC class I protein complex;GO:0098553 lumenal side of endoplasmic reticulum membrane;GO:0032398 MHC class Ib protein complex;GO:0000139 Golgi membrane", "go_biological_process": "GO:0006955 immune response;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I;GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0010977 negative regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P14427-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01921-1", "uniprot_id": "HB2D_MOUSE", "mass": 29954.0, "length": 265, "protein_name": "H-2 class II histocompatibility antigen, A-D beta chain", "gene_name": "H2-Ab1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H2-Ab1; H2-iabeta", "gene_names_refseq": "", "protein_names_uniprotkb": "H-2 class II histocompatibility antigen, A-D beta chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "autoimmune pancreatitis (Disease Ontology:DOID:0040091); chikungunya (Disease Ontology:DOID:0050012); autoimmune polyendocrine syndrome type 2 (Disease Ontology:DOID:0050168); erythema multiforme (Disease Ontology:DOID:0050185); Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); marginal zone lymphoma (Disease Ontology:DOID:0050748); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); rheumatic heart disease (Disease Ontology:DOID:0050827); cervical dystonia (Disease Ontology:DOID:0050840); stroke (Disease Ontology:DOID:0051061); immunoglobulin alpha deficiency (Disease Ontology:DOID:0060025); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); latex allergy (Disease Ontology:DOID:0060532); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); pemphigus vulgaris (Disease Ontology:DOID:0060851); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); osteomyelitis (Disease Ontology:DOID:1019); pneumoconiosis (Disease Ontology:DOID:10316); silicosis (Disease Ontology:DOID:10325); bacterial infectious disease (Disease Ontology:DOID:104); pre-eclampsia (Disease Ontology:DOID:10591); celiac disease (Disease Ontology:DOID:10608); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); sickle cell anemia (Disease Ontology:DOID:10923); common wart (Disease Ontology:DOID:11165); sarcoidosis (Disease Ontology:DOID:11335); rhinoscleroma (Disease Ontology:DOID:11336); pneumocystosis (Disease Ontology:DOID:11339); cicatricial pemphigoid (Disease Ontology:DOID:11656); degenerative myopia (Disease Ontology:DOID:11829); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); allergic disease (Disease Ontology:DOID:1205); optic neuritis (Disease Ontology:DOID:1210); alveolar echinococcosis (Disease Ontology:DOID:12148); common variable immunodeficiency (Disease Ontology:DOID:12177); beta thalassemia (Disease Ontology:DOID:12241); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); aplastic anemia (Disease Ontology:DOID:12449); vulva cancer (Disease Ontology:DOID:1245); choreatic disease (Disease Ontology:DOID:12859); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); agranulocytosis (Disease Ontology:DOID:12987); uveitis (Disease Ontology:DOID:13141); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); Behcet's disease (Disease Ontology:DOID:13241); typhoid fever (Disease Ontology:DOID:13258); pure red-cell aplasia (Disease Ontology:DOID:1340); Addison's disease (Disease Ontology:DOID:13774); autoimmune polyendocrine syndrome (Disease Ontology:DOID:14040); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); hypothyroidism (Disease Ontology:DOID:1459); cystic echinococcosis (Disease Ontology:DOID:1495); rheumatic fever (Disease Ontology:DOID:1586); glaucoma (Disease Ontology:DOID:1686); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); dental caries (Disease Ontology:DOID:216); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); antiphospholipid syndrome (Disease Ontology:DOID:2988); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); tuberculosis (Disease Ontology:DOID:399); multidrug-resistant tuberculosis (Disease Ontology:DOID:401); autoimmune disease (Disease Ontology:DOID:417); cervical cancer (Disease Ontology:DOID:4362); myasthenia gravis (Disease Ontology:DOID:437); rhinitis (Disease Ontology:DOID:4483); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myositis (Disease Ontology:DOID:633); acute disseminated encephalomyelitis (Disease Ontology:DOID:639); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); autoimmune thyroiditis (Disease Ontology:DOID:7188); stomach disease (Disease Ontology:DOID:76); hyperthyroidism (Disease Ontology:DOID:7998); myocarditis (Disease Ontology:DOID:820); arthritis (Disease Ontology:DOID:848); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); mycosis fungoides (Disease Ontology:DOID:8691); Crohn's disease (Disease Ontology:DOID:8778); neuromyelitis optica (Disease Ontology:DOID:8869); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); atrophic gastritis (Disease Ontology:DOID:8929); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); achalasia (Disease Ontology:DOID:9164); pemphigus (Disease Ontology:DOID:9182); colorectal cancer (Disease Ontology:DOID:9256); iridocyclitis (Disease Ontology:DOID:9383); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:14961); (R-MMU-202424); (R-MMU-202427); (R-MMU-202430); (R-MMU-202433); (R-MMU-2132295); (R-MMU-389948)", "pathway_count": 7, "publication_count": 24, "publication_id_list": "11180120;11465105;1649218;17051151;17174123;21750661;21913724;2512582;2555693;26495903;28935714;29187734;3086866;33725478;34428180;35984892;3692165;37828378;3980466;6311906;6407114;6410508;6411350;9529148", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 105, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O19456;O19457;O19458;Q31133;Q31138;Q31139", "ec_number_list": "", "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding;GO:0044877 protein-containing complex binding;GO:0015643 toxic substance binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0042613 MHC class II protein complex;GO:0005771 multivesicular body", "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002250 adaptive immune response;GO:0006955 immune response;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0050870 positive regulation of T cell activation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P01921-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09051-1", "uniprot_id": "GUC2B_MOUSE", "mass": 11628.0, "length": 106, "protein_name": "Guanylate cyclase activator 2B", "gene_name": "Guca2b", "organism": "Mouse", "refseq_name": "guanylate cyclase activator 2B preproprotein", "refseq_ac": "NP_032217", "gene_names_uniprotkb": "Guca2b", "gene_names_refseq": "Gcap2; Guca2b; Ugn", "protein_names_uniprotkb": "Guanylate cyclase activator 2B", "protein_names_refseq": "granule cell antiserum positive 2; guanylate cyclase activator 2B preproprotein; guanylate cyclase activator 2b (retina); uroguanylin", "tax_id": 10090, "disease": "", "pathway": " (mmu:14916); (R-MMU-8935690)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;25743370;27246004;29289697;9287995", "class_list": "", "function": "Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage, [RefSeq, PubMed]; Guanylin and uroguanylin, as well as their prohormones, do not seem to play a significant role in body weight regulation and glycemic control, suggesting that guanylin-family peptides do not show promise as targets for the treatment of obesity or diabetes., [RefSeq, PubMed]; In obese mice UGN expression was decreased, whereas leptin treatment up-regulated UGN levels in duodenum in these genetically modified mice compared to WT., [RefSeq, PubMed]; This gene encodes a member of the guanylin family and preproprotein that is proteolytically processed to generate a mature protein product. The mature protein product, known as uroguanylin, is an endogenous ligand for the guanylate cyclase-C receptor and may regulate salt and water homeostasis in the intestine and kidneys. Homozygous knockout mice for this gene exhibit impaired sodium chloride excretion and elevated arterial pressure. This gene is present in a gene cluster with a related guanylin family member on chromosome 4. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030250 guanylate cyclase activator activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0060612 adipose tissue development;GO:0045776 negative regulation of blood pressure;GO:0097009 energy homeostasis;GO:0035264 multicellular organism growth;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O09051-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22272-1", "uniprot_id": "IL6RA_MOUSE", "mass": 50455.0, "length": 460, "protein_name": "Interleukin-6 receptor subunit alpha", "gene_name": "Il6ra", "organism": "Mouse", "refseq_name": "interleukin-6 receptor subunit alpha isoform 1 precursor", "refseq_ac": "NP_034689", "gene_names_uniprotkb": "Il6ra; Il6r", "gene_names_refseq": "CD126; IL-6R-alpha; IL-6RA; IL-6R; Il6ra; Il6r", "protein_names_uniprotkb": "Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA", "protein_names_refseq": "IL-6 receptor alpha chain; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; interleukin-6 receptor subunit alpha isoform 1 precursor; interleukin-6 receptor subunit alpha", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); sleep apnea (Disease Ontology:DOID:0050847); hyper IgE syndrome (Disease Ontology:DOID:0080545); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); Graves' disease (Disease Ontology:DOID:12361); Huntington's disease (Disease Ontology:DOID:12858); uveitis (Disease Ontology:DOID:13141); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); depressive disorder (Disease Ontology:DOID:1596); orchitis (Disease Ontology:DOID:2518); pulmonary tuberculosis (Disease Ontology:DOID:2957); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16194); (R-MMU-1059683); (R-MMU-110056); (R-MMU-112411); (R-MMU-9958825)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11113088;2112585;21750661;26740625;26876177;27893700;28402851;30084848;30995492", "class_list": "", "function": "Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable). Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (PubMed:27893700)., [UniProtKB, PubMed, PubMed]; Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory. Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells., [UniProtKB, UniProtKB]; Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed:11113088). The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (By similarity). In complex with IL6, is required for induction of VEGF production (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (PubMed:11113088). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (PubMed:28402851)., [UniProtKB, PubMed, PubMed, UniProtKB]; Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases. In complex with IL6, is required for induction of VEGF production. Plays a protective role during liver injury, being required for maintenance of tissue regeneration. 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 18, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004897 ciliary neurotrophic factor receptor activity;GO:0004915 interleukin-6 receptor activity;GO:0004921 interleukin-11 receptor activity;GO:0019970 interleukin-11 binding;GO:0019981 interleukin-6 binding", "go_cellular_component": "GO:0070110 ciliary neurotrophic factor receptor complex;GO:0005896 interleukin-6 receptor complex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0072126 positive regulation of glomerular mesangial cell proliferation;GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0032722 positive regulation of chemokine production", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P22272-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N32-1", "uniprot_id": "KLOTB_MOUSE", "mass": 120189.0, "length": 1043, "protein_name": "Beta-klotho", "gene_name": "Klb", "organism": "Mouse", "refseq_name": "beta-klotho", "refseq_ac": "NP_112457", "gene_names_uniprotkb": "Klb; Betakl", "gene_names_refseq": "Klb; betaKlotho", "protein_names_uniprotkb": "Beta-klotho; BKL; BetaKlotho; Klotho beta-like protein", "protein_names_refseq": "BKL; beta-klotho; klotho beta-like protein", "tax_id": 10090, "disease": "kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:83379); (R-MMU-109704); (R-MMU-1257604); (R-MMU-1307965); (R-MMU-5654228); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5654720); (R-MMU-5654733); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 11, "publication_count": 6, "publication_id_list": "11044614;16075061;17452648;20173027;30084848;34428180", "class_list": "glycogene;glycosylhydrolase", "function": "BetaKlotho functions as a cofactor essential for fibroblast growth factor 21 activity, [RefSeq, PubMed]; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 56, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "B2RQN8;Q920J2;Q99N31", "ec_number_list": "", "go_molecular_function": "GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0017134 fibroblast growth factor binding;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0005975 carbohydrate metabolic process;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99N32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUR7-1", "uniprot_id": "PIN1_MOUSE", "mass": 18370.0, "length": 165, "protein_name": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1", "gene_name": "Pin1", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform 1", "refseq_ac": "NP_075860", "gene_names_uniprotkb": "Pin1", "gene_names_refseq": "0610025L01Rik; D9Bwg1161e; Pin1", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; 5.2.1.8; PPIase Pin1; Peptidyl-prolyl cis-trans isomerase Pin1", "protein_names_refseq": "PPIase Pin1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform 1; peptidyl-prolyl cis-trans isomerase Pin1; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; rotamase Pin1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); secondary hyperparathyroidism (Disease Ontology:DOID:12466); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:23988); (R-MMU-5668599); (R-MMU-6804756); (R-MMU-6811555); (R-MMU-936440)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10600477;12397361;16024801;17828269;19367327;20215645;21400615;21952136;22926167;29686383;30893596;32448390;34428180;37990376;38676996;38833897", "class_list": "", "function": "Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs (PubMed:29686383, PubMed:30893596). By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:29686383, PubMed:30893596). Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (By similarity). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (By similarity). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (By similarity). Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells (PubMed:29686383). Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion (By similarity). Acts as a negative regulator of adipocyte browning by binding to phosphorylated PRDM16, targeting PRDM16 for degradation (PubMed:30893596)., [UniProtKB, UniProtKB, PubMed, PubMed]; Pin1 maintains the effector program of pathogenic Th17 cells in autoimmune neuroinflammation., [RefSeq, PubMed]; Prolyl isomerase Pin1 in skeletal muscles contributes to systemic energy metabolism and exercise capacity through regulating SERCA activity., [RefSeq, PubMed]; The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response Erratum:[Nature 2002 Nov 28;420(6914):445], [RefSeq, PubMed]; Upregulation of Pin1 contributes to alleviation of cognitive dysfunction in diabetic mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543B3", "ec_number_list": "5.2.1.8;2.7.1.149;2.7.11.13;2.7.10.2;2.7.11.1", "go_molecular_function": "GO:0031434 mitogen-activated protein kinase kinase binding;GO:0050815 phosphoserine residue binding;GO:0051219 phosphoprotein binding;GO:0008013 beta-catenin binding;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050808 synapse organization;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9QUR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62874-1", "uniprot_id": "GBB1_MOUSE", "mass": 37377.0, "length": 340, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "gene_name": "Gnb1", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "refseq_ac": "NP_001153488", "gene_names_uniprotkb": "Gnb1", "gene_names_refseq": "Gnb-1; Gnb1; Hg2a", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Transducin beta chain 1", "protein_names_refseq": "guanine nucleotide binding protein, beta 1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; heterotrimeric guanine nucleotide-binding protein 2a; transducin beta chain 1", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); autosomal dominant intellectual developmental disorder 42 (Disease Ontology:DOID:0070072); congestive heart failure (Disease Ontology:DOID:6000); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:14688); (R-MMU-1296041); (R-MMU-202040); (R-MMU-2485179); (R-MMU-381676); (R-MMU-381753); (R-MMU-381771); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9717207); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 32, "publication_count": 7, "publication_id_list": "11913780;21750661;22645316;33300544;34203471;34428180;40885482", "class_list": "glycogene", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (By similarity). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P04697;P04901", "ec_number_list": "", "go_molecular_function": "GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0003924 GTPase activity;GO:0030507 spectrin binding;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043209 myelin sheath;GO:0045202 synapse", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008283 cell population proliferation;GO:0071456 cellular response to hypoxia;GO:0007603 phototransduction, visible light", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P62874-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60928-1", "uniprot_id": "GGT1_MOUSE", "mass": 61563.0, "length": 568, "protein_name": "Glutathione hydrolase 1 proenzyme", "gene_name": "Ggt1", "organism": "Mouse", "refseq_name": "glutathione hydrolase 1 proenzyme precursor", "refseq_ac": "NP_001292921", "gene_names_uniprotkb": "Ggt1; Ggtp; Ggt", "gene_names_refseq": "CD224; GGT 1; GGT-1; GGT; Ggt1; Ggtp; dwg", "protein_names_uniprotkb": "Glutathione hydrolase 1 proenzyme; 2.3.2.2; 3.4.19.13; 3.4.19.14; GGT 1; Gamma-glutamyltransferase 1; Gamma-glutamyltranspeptidase 1; Leukotriene-C4 hydrolase", "protein_names_refseq": "gamma-glutamyltranspeptidase 1; glutathione hydrolase 1 proenzyme precursor; glutathione hydrolase 1 proenzyme; leukotriene-C4 hydrolase", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); gamma-glutamyl transpeptidase deficiency (Disease Ontology:DOID:0111257); gestational diabetes (Disease Ontology:DOID:11714); biliary atresia (Disease Ontology:DOID:13608); melanoma (Disease Ontology:DOID:1909); aflatoxins-related hepatocellular carcinoma (Disease Ontology:DOID:5022); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:14598); (R-MMU-174403); (R-MMU-2142691); (R-MMU-5423646); (R-MMU-9753281)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10392451;12810527;19349973;21750661;30084848;30591459;30899004;8566783;8755578;9139708", "class_list": "", "function": "Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4 (By similarity). Indirectly regulates multiple aspects of skeletal biology (PubMed:12810527)., [UniProtKB, PubMed, UniProtKB]; GGsTop is a newly-discovered gamma-glutamyl transpeptidase (GGT) inhibitor...GGsTop treated Oral mucositis (OM) quickly and safely. GGsTop is highly valuable for use as a treatment for OM, [RefSeq, PubMed]; This gene encodes gamma-glutamyl transpeptidase, a plasmamembrane-associated enzyme that cleaves the peptide bond between gamma-glutamyl and cysteinyl glycine moieties of glutathione. The encoded protein is autocatalytically processed to generate an enzymatically active heterodimer comprised of heavy and light chains. Mice lacking the encoded protein grow slowly, develop cataracts and have elevated levels of glutathione in plasma and urine. Transgenic overexpression of the encoded protein in mice enhances osteoclastic bone resorption. The mutant alleles termed 'Dwarf grey' and 'Dwarf grey Bayer' in mice are associated with deletions in this gene. A gamma-glutamyl transpeptidase paralog is located adjacent to this gene. Alternative splicing results in multiple transcript variants. Additional transcripts using alternate promoters and differing in 5' UTRs have been described. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 8796, "biomarker_type": "", "glycan_count": 15, "disease_count": 14, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.2;3.4.19.13;3.4.19.14", "go_molecular_function": "GO:0000048 peptidyltransferase activity;GO:0002951 leukotriene-C(4) hydrolase;GO:0036374 glutathione hydrolase activity;GO:0016755 aminoacyltransferase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0031982 vesicle", "go_biological_process": "GO:0061017 hepatoblast differentiation;GO:0006750 glutathione biosynthetic process;GO:0006751 glutathione catabolic process;GO:0097305 response to alcohol;GO:0006536 glutamate metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q60928-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50431-1", "uniprot_id": "GLYC_MOUSE", "mass": 52601.0, "length": 478, "protein_name": "Serine hydroxymethyltransferase, cytosolic", "gene_name": "Shmt1", "organism": "Mouse", "refseq_name": "serine hydroxymethyltransferase, cytosolic isoform 1", "refseq_ac": "NP_033197", "gene_names_uniprotkb": "Shmt1; Shmt", "gene_names_refseq": "Shmt1; Shmt; cSHMT; mshmt1; mshmt2; mshmt", "protein_names_uniprotkb": "Serine hydroxymethyltransferase, cytosolic; 2.1.2.1; Glycine hydroxymethyltransferase; SHMT; Serine methylase; cSHMT", "protein_names_refseq": "glycine hydroxymethyltransferase; serine hydroxymethyltransferase, cytosolic isoform 1; serine hydroxymethyltransferase, cytosolic; serine methylase", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:20425); (R-MMU-196757); (R-MMU-71262)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11063567;18299400;21750661;21952136;25605945;30084848;30779550;31219806;31616917;34428180;37453647;37752684;8863732", "class_list": "", "function": "HOXD8 suppresses renal cell carcinoma growth by upregulating SHMT1 expression., [RefSeq, PubMed]; Interconversion of serine and glycine., [UniProtKB, UniProtKB, UniProtKB]; Pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate (THF) to glycine and 5,10-methylene THF, serving as a critical component of the folate cycle and facilitating one-carbon biosynthetic reactions essential for methionine, purine, and pyrimidine synthesis (By similarity). While its central activity involves serine cleavage, the detailed catalytic mechanisms remain under study, including both retro-aldol cleavage of the PLP-serine C(alpha)-C(beta) bond followed by formaldehyde condensation with THF, and alternative nucleophilic displacement mechanisms of the C(alpha) atom of PLP-serine aldimine involving THF's N5 atom (By similarity). Also catalyzes the cleavage of various 3-hydroxy amino acids, such as L-allo-threonine, L-threonine and 3-phenylserine, forming glycine and the corresponding aldehyde through a retro-aldol process; additionally, it catalyzes the formation of 5-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate. Also functions as a hydroxytrimethyllysine aldolase (HTMLA) catalyzing the second step of the carnitine biosynthesis pathway and exhibits substrate preference with the erythro (S,S) configuration, and more efficiency with L-allo-threonine (By similarity). In the nucleus, first functions as a lamin-binding scaffold protein that is essential for assembling the de novo thymidylate synthesis complex by co-localizing DHFR and TYMS with the nuclear lamina and anchoring the complex to DNA replication sites. Subsequently, provides one-carbon substrates, specifically (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, in situ for de novo dTMP synthesis to sustain DNA replication and repair during cell proliferation. Importantly, possesses RNA-binding capability, forming complexes that selectively regulate SHMT2 mRNA translation and dynamically modulate cytosolic and mitochondrial serine and glycine concentrations, thus influencing cellular metabolic status (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q64508;Q8R0X9", "ec_number_list": "2.1.2.1", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016597 amino acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006231 dTMP biosynthetic process;GO:0006545 glycine biosynthetic process;GO:0051289 protein homotetramerization;GO:1990830 cellular response to leukemia inhibitory factor;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P50431-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YI6-1", "uniprot_id": "GLD2_MOUSE", "mass": 55934.0, "length": 484, "protein_name": "Poly(A) RNA polymerase GLD2", "gene_name": "Tent2", "organism": "Mouse", "refseq_name": "poly(A) RNA polymerase GLD2 isoform 1", "refseq_ac": "NP_598666", "gene_names_uniprotkb": "Tent2; Gld2; Papd4", "gene_names_refseq": "8030446C20Rik; GLD-2; Gld2; Papd4; Tent2", "protein_names_uniprotkb": "Poly(A) RNA polymerase GLD2; 2.7.7.19; PAP-associated domain-containing protein 4; Terminal nucleotidyltransferase 2; mGLD-2", "protein_names_refseq": "PAP associated domain containing 4; PAP-associated domain-containing protein 4; cytoplasmic poly(A) polymerase; poly(A) RNA polymerase GLD2 isoform 1; poly(A) RNA polymerase GLD2", "tax_id": 10090, "disease": "", "pathway": " (mmu:100715)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15070731;15987818;16325797;17927953;19240131;21750661;22727665;27495319;27802388;32954964;34428180;35820727", "class_list": "", "function": "Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs., [UniProtKB, UniProtKB]; Identified GLD-2, which is a regulatory cytoplasmic poly(A) polymerase, as responsible for the 3'-terminal adenylation of miR-122 after unwinding of the miR-122/miR-122* duplex, [RefSeq, PubMed]; In Gld2 knockout mice there are detectable alterations in specific miRNA monoadenylation in the hippocampus, but no detectable effect on miRNA stability and no overt change in animal behavior., [RefSeq, PubMed]; MGLD-2 may act in the ooplasm on the progression of metaphase I to metaphase II during oocyte maturation., [RefSeq, PubMed]; Noncanonical cytoplasmic poly(A) polymerases regulate RNA levels, alternative RNA processing, and synaptic plasticity but not hippocampal-dependent behaviours., [RefSeq, PubMed]; Poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus, [RefSeq, PubMed]; We found an association of mGLD-2 with cytoplasmic polyadenylation components, CPEB and CPSF described in Xenopus oocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4F5H0;Q8CCH5", "ec_number_list": "2.7.7.19;2.7.7.52;2.7.7.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0098794 postsynapse;GO:0140240 perforant pathway to dendrate granule cell synapse", "go_biological_process": "GO:0090314 positive regulation of protein targeting to membrane;GO:0002244 hematopoietic progenitor cell differentiation;GO:0071044 histone mRNA catabolic process;GO:0031124 mRNA 3'-end processing;GO:0031123 RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91YI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ92-1", "uniprot_id": "FIS1_MOUSE", "mass": 17009.0, "length": 152, "protein_name": "Mitochondrial fission 1 protein", "gene_name": "Fis1", "organism": "Mouse", "refseq_name": "mitochondrial fission 1 protein isoform 2", "refseq_ac": "NP_001156715", "gene_names_uniprotkb": "Fis1; Ttc11", "gene_names_refseq": "2010003O14Rik; Fis1; Ttc11", "protein_names_uniprotkb": "Mitochondrial fission 1 protein; FIS1 homolog; TPR repeat protein 11; Tetratricopeptide repeat protein 11", "protein_names_refseq": "FIS1 homolog; TPR repeat protein 11; fission 1 (mitochondrial outer membrane) homolog; mitochondrial fission 1 protein isoform 2; mitochondrial fission 1 protein; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); dental fluorosis (Disease Ontology:DOID:13711); acute kidney failure (Disease Ontology:DOID:3021); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:66437); (R-MMU-9603798)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;23283981;34428180;36288343;37468472;37507081", "class_list": "", "function": "Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:23283981). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (PubMed:23283981). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (By similarity). Also mediates peroxisomal fission (By similarity). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (By similarity). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity)., [UniProtKB, UniProtKB, PubMed]; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event. Also mediates peroxisomal fission. May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis., [UniProtKB, UniProtKB, UniProtKB]; Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0016559 peroxisome fission;GO:0006626 protein targeting to mitochondrion;GO:0043525 positive regulation of neuron apoptotic process;GO:0007005 mitochondrion organization;GO:1901653 cellular response to peptide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CQ92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXY9-1", "uniprot_id": "GPI8_MOUSE", "mass": 44895.0, "length": 395, "protein_name": "GPI-anchor transamidase", "gene_name": "Pigk", "organism": "Mouse", "refseq_name": "GPI-anchor transamidase isoform 1 precursor", "refseq_ac": "NP_079938", "gene_names_uniprotkb": "Pigk", "gene_names_refseq": "3000001O05Rik; Gm38470; PIG-K; Pigk", "protein_names_uniprotkb": "GPI-anchor transamidase; 2.6.1.-; GPI-anchor transamidase component PIGK; PIG-K; Phosphatidylinositol-glycan biosynthesis class K protein", "protein_names_refseq": "GPI transamidase; GPI-anchor transamidase component PIGK; GPI-anchor transamidase isoform 1 precursor; GPI-anchor transamidase; phosphatidylinositol-glycan biosynthesis class K protein", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202)", "pathway": " (mmu:329777); (R-MMU-162791)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;30059200;31219806;9356492", "class_list": "glycogene", "function": "Catalytic subunit of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis. Recognizes diverse proproteins at a C-terminal signal peptide (CSP) region that lacks consensus sequence and replaces it with a GPI-anchor via a transamidation reaction. Transamidation catalysis reaction follows a two-phase mechanism. In the acyl-enzyme phase, the carbonyl group of the proproteins's omega-site undergoes a nucleophilic attack forming an enzyme-substrate thioester bond. Followed by a general acid catalysis that allows CSP releasing, regenerating the carbonyl, and forming the acyl-enzyme intermediate. In the GPI-anchor attachment phase, the amino group of the GPI-anchor's ethanolamine phosphate, the one on third mannose (EtNP3), mediates a nucleophilic attack on the carbonyl of the acyl-enzyme intermediate, replacing the CSP, allowing GPI-anchor attachment to the omega-residue, therefore forming the product and freeing the enzyme., [UniProtKB, UniProtKB]; The protein encoded by the human ortholog catalyzes the final step in glycosylphosphatidylinositol (GPI) anchoring of cell surface proteins, the transamidation reaction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH63", "ec_number_list": "2.6.1.-", "go_molecular_function": "GO:0003923 GPI-anchor transamidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0042765 GPI-anchor transamidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein;GO:0180046 GPI anchored protein biosynthesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CXY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920S3-1", "uniprot_id": "GATD1_MOUSE", "mass": 28535.0, "length": 266, "protein_name": "GATA zinc finger domain-containing protein 1", "gene_name": "Gatad1", "organism": "Mouse", "refseq_name": "GATA zinc finger domain-containing protein 1", "refseq_ac": "NP_080309", "gene_names_uniprotkb": "Gatad1; Odag", "gene_names_refseq": "2310031E19Rik; 2810047M21Rik; 8430439A17Rik; 9130430G15Rik; B330017N08Rik; Gatad1; Odag", "protein_names_uniprotkb": "GATA zinc finger domain-containing protein 1; Ocular development-associated gene protein", "protein_names_refseq": "GATA zinc finger domain-containing protein 1; ocular development associated; ocular development-associated gene protein", "tax_id": 10090, "disease": "dilated cardiomyopathy 2B (Disease Ontology:DOID:0110441)", "pathway": " (mmu:67210)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12062807;21750661;21965549", "class_list": "", "function": "Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCQ2;Q9CSG2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q920S3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9QAG8-1", "uniprot_id": "ZN431_MOUSE", "mass": 61280.0, "length": 526, "protein_name": "Zinc finger protein 431", "gene_name": "Zfp932; Znf431", "organism": "Mouse", "refseq_name": "zinc finger protein 431 isoform 1", "refseq_ac": "NP_663538", "gene_names_uniprotkb": "Zfp932; Znf431; Zfp431; Zfp932", "gene_names_refseq": "2310001H12Rik; Zfp932; Znf431", "protein_names_uniprotkb": "Zinc finger protein 431; Zinc finger protein 932", "protein_names_refseq": "zinc finger protein 431 isoform 1; zinc finger protein 431", "tax_id": 10090, "disease": "", "pathway": " (mmu:69504)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21177534;21750661;22391310", "class_list": "", "function": "Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1., [UniProtKB, PubMed, PubMed]; ZNF431 directly represses Patched1 expression and likely functions to repress the hedgehog response in cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045668 negative regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9QAG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08752-1", "uniprot_id": "GNAI2_MOUSE", "mass": 40489.0, "length": 355, "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-2", "gene_name": "Gnai2", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(i) subunit alpha-2", "refseq_ac": "NP_032164", "gene_names_uniprotkb": "Gnai2; Gnai-2", "gene_names_refseq": "Galphai2; Gia; Gnai-2; Gnai2; Hg1c", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(i) subunit alpha-2; 3.6.5.-; Adenylate cyclase-inhibiting G alpha protein", "protein_names_refseq": "adenylate cyclase-inhibiting G alpha protein; guanine nucleotide binding protein (G protein), alpha inhibiting 2; guanine nucleotide-binding protein G(i) subunit alpha-2; heterotrimeric guanine nucleotide-binding protein 1c", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); inflammatory bowel disease 12 (Disease Ontology:DOID:0110887); hypertension (Disease Ontology:DOID:10763); McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (mmu:14678); (R-MMU-170670); (R-MMU-392170); (R-MMU-400042); (R-MMU-418594); (R-MMU-9009391)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "16479539;21750661;22645316;22872234;23225882;26495903;28528544;29125738;3092218;31219806;32152506;34203471;34428180;36210013;38153649;39627609;8170357", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. Examples of interacting GPCRs include the adenosine A1 receptor/ADORA1, CNR1, and FPR2. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels. Plays an important role in the activation of the transcription factor NFAT in endothelial cells to promote angiogenesis. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. Plays an essential role for neutrophil recruitment in the context of acute inflammation suggesting a linked function of both GNAI2 in neutrophils and endothelial cells for polymorphonuclear neutrophils transmigration (PubMed:23225882)., [UniProtKB, UniProtKB, PubMed]; MiR-30c-5p-Targeted Regulation of GNAI2 Improves Neural Function Injury and Inflammation in Cerebral Ischemia-Reperfusion Injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXK7;Q6P1C0", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;4.6.1.1;2.7.10.2;3.6.5.4;3.6.5.5;2.7.7.85;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0001525 angiogenesis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P08752-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBY0-1", "uniprot_id": "FOXP4_MOUSE", "mass": 85981.0, "length": 795, "protein_name": "Forkhead box protein P4", "gene_name": "Foxp4", "organism": "Mouse", "refseq_name": "forkhead box protein P4 isoform 1", "refseq_ac": "NP_001104294", "gene_names_uniprotkb": "Foxp4", "gene_names_refseq": "1200010K03Rik; 2310007G05Rik; Foxp4; mFKHLA", "protein_names_uniprotkb": "Forkhead box protein P4; Fork head-related protein-like A; mFKHLA", "protein_names_refseq": "fork head-related protein like A; forkhead box protein P4 isoform 1; forkhead box protein P4", "tax_id": 10090, "disease": "specific developmental disorder (Disease Ontology:DOID:0060038); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:74123)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12818433;14516685;14701752;18299400;21750661;25428506;32152506;34428180", "class_list": "", "function": "Complex regulatory mechanism underlying Foxp1, Foxp2, and Foxp4 activity, demonstrating that Foxp1, Foxp2, and Foxp4 are the first Fox proteins reported whose activity is regulated by homo- and heterodimerization, [RefSeq, PubMed]; In adult tissues FoxP4 is expressed in heart, brain, lung, liver, kidney, and testis.In situ hybridization revealed expression of FoxP4 in the developing lung and gut, [RefSeq, PubMed]; Transcriptional repressor that represses lung-specific expression., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80V92;Q8CG10;Q8CIS1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0048617 embryonic foregut morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DBY0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K013-1", "uniprot_id": "GTPBA_MOUSE", "mass": 40142.0, "length": 366, "protein_name": "GTP-binding protein 10", "gene_name": "Gtpbp10", "organism": "Mouse", "refseq_name": "GTP-binding protein 10 isoform 1.", "refseq_ac": "NP_694756", "gene_names_uniprotkb": "Gtpbp10", "gene_names_refseq": "4930545J22Rik; Gtpbp10", "protein_names_uniprotkb": "GTP-binding protein 10", "protein_names_refseq": "GTP-binding protein 10 isoform 1.", "tax_id": 10090, "disease": "", "pathway": " (mmu:207704)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35822049", "class_list": "", "function": "May be involved in the ribosome maturation process., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019843 rRNA binding;GO:0140978 mitochondrial large ribosomal subunit binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K013-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D968-1", "uniprot_id": "HCFC2_MOUSE", "mass": 79435.0, "length": 722, "protein_name": "Host cell factor 2", "gene_name": "Hcfc2", "organism": "Mouse", "refseq_name": "host cell factor 2 isoform 1", "refseq_ac": "NP_001074687", "gene_names_uniprotkb": "Hcfc2", "gene_names_refseq": "1700129L13Rik; Hcfc2; fkls", "protein_names_uniprotkb": "Host cell factor 2; C2 factor; HCF-2", "protein_names_refseq": "C2 factor; HCF-2; host cell factor 2 isoform 1; host cell factor 2", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:67933); (R-MMU-9772755)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;28970238;31049581;31112734;34428180;34887587", "class_list": "", "function": "Data show that HCFC2 is a critical component of the IRF1 and IRF2 transcriptional machinery that regulates Tlr3 gene expression., [RefSeq, PubMed]; HCF-2 is broadly present in human and mouse cells, and possesses activities distinct from HCF-1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G5E837", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D968-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61121-1", "uniprot_id": "GPR19_MOUSE", "mass": 47533.0, "length": 415, "protein_name": "Probable G protein-coupled receptor 19", "gene_name": "Gpr19", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 19 isoform a", "refseq_ac": "NP_001161166", "gene_names_uniprotkb": "Gpr19", "gene_names_refseq": "Gpr19", "protein_names_uniprotkb": "Probable G protein-coupled receptor 19", "protein_names_refseq": "probable G-protein coupled receptor 19 isoform a; probable G-protein coupled receptor 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:14760)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;31219806;34789778;37061564;37743028", "class_list": "", "function": "G protein-coupled receptor that plays a role in the regulation of circadian rhythms and energy metabolism (PubMed:34789778, PubMed:37061564). Participates in maintaining proper circadian gene expression in the suprachiasmatic nucleus (SCN), the locus of the master circadian clock in the brain (PubMed:34789778). May function as a coordinator of aging-associated metabolic dysfunction, stress response, DNA integrity management, and eventual senescence (By similarity). Upon binding to adropin, modulates mitochondrial energy metabolism via the p44/42-PDK4 signaling pathway, influencing pyruvate dehydrogenase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; G-protein coupled receptor that plays a role in the regulation of circadian rhythms and energy metabolism. Participates in maintaining proper circadian gene expression in the suprachiasmatic nucleus (SCN), the locus of the master circadian clock in the brain. May function as a coordinator of aging-associated metabolic dysfunction, stress response, DNA integrity management, and eventual senescence. Upon binding to adropin, modulates mitochondrial energy metabolism via the p44/42-PDK4 signaling pathway, influencing pyruvate dehydrogenase activity., [UniProtKB, UniProtKB, UniProtKB]; Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock. Publication Status: Online-Only, [RefSeq, PubMed]; Ontogeny of adropin and its receptor expression during postnatal development and its pro-gonadal role in the ovary of pre-pubertal mouse., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q810I4;Q8VDJ9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61121-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CRB3-1", "uniprot_id": "HIUH_MOUSE", "mass": 13559.0, "length": 118, "protein_name": "5-hydroxyisourate hydrolase", "gene_name": "Urah", "organism": "Mouse", "refseq_name": "5-hydroxyisourate hydrolase isoform 2", "refseq_ac": "NP_084097", "gene_names_uniprotkb": "Urah", "gene_names_refseq": "1190003J15Rik; 2810420C16Rik; HIUHase; Urah", "protein_names_uniprotkb": "5-hydroxyisourate hydrolase; 3.5.2.17; HIU hydrolase; HIUHase; Transthyretin-related protein", "protein_names_refseq": "5-hydroxyisourate hydrolase isoform 2; 5-hydroxyisourate hydrolase; HIU hydrolase; transthyretin-related protein", "tax_id": 10090, "disease": "hyperuricemia (Disease Ontology:DOID:1920)", "pathway": " (mmu:76974)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16462750;17085964;20823251;21750661;34428180", "class_list": "", "function": "Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)., [UniProtKB, UniProtKB, UniProtKB]; Identified as the gene encoding the enzyme catalyzing the second step of the pathway from uric acid to S-allantoin., [RefSeq, PubMed]; Study provides evidence that mouse transthyretin-related protein facilitates the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction., [RefSeq, PubMed]; Substitution of cysteine for tyrosine in a conserved helical region of HIU hydrolase resulted in undetectable protein expression. Homozygotes for the mutation had elevated platelet counts secondary to excess thrombopoietin production and hepatomegaly., [RefSeq, PubMed]; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.2.17", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0033971 hydroxyisourate hydrolase activity;GO:0070324 thyroid hormone binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005576 extracellular region", "go_biological_process": "GO:0019628 urate catabolic process;GO:0006154 adenosine catabolic process;GO:0006157 deoxyadenosine catabolic process;GO:0006196 AMP catabolic process;GO:0009115 xanthine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CRB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61107-1", "uniprot_id": "GBP3_MOUSE", "mass": 70801.0, "length": 620, "protein_name": "Guanylate-binding protein 3", "gene_name": "Gbp3", "organism": "Mouse", "refseq_name": "guanylate-binding protein 3", "refseq_ac": "NP_001276421", "gene_names_uniprotkb": "Gbp3", "gene_names_refseq": "GBP-3; GBP-4; Gbp3; Gbp4", "protein_names_uniprotkb": "Guanylate-binding protein 3; 3.6.5.-; GBP-3; GTP-binding protein 3; Guanine nucleotide-binding protein 3", "protein_names_refseq": "GTP-binding protein 3; GTP-binding protein 4; guanine nucleotide-binding protein 3; guanine nucleotide-binding protein 4; guanylate nucleotide binding protein 3; guanylate nucleotide binding protein 4; guanylate-binding protein 3; guanylate-binding protein 4; putative purine nucleotide binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:55932)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;18025219;19224205;20173027;21750661;24715728;24739961;25428506;25428507;25605945;26495903;30084848;30779550;31599954;34428180;35820727;36210013;37621179;9659399", "class_list": "", "function": "Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis., [RefSeq, PubMed]; Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:24715728, PubMed:24739961). Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product (PubMed:9659399). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24715728, PubMed:24739961). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24715728, PubMed:24739961). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24715728, PubMed:24739961). May play a role in erythroid differentiation (PubMed:9659399)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VEC5", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0044406 adhesion of symbiont to host;GO:0050830 defense response to Gram-positive bacterium;GO:0071222 cellular response to lipopolysaccharide;GO:0042742 defense response to bacterium;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q61107-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UTB7-1", "uniprot_id": "FOXR1_MOUSE", "mass": 30579.0, "length": 268, "protein_name": "Forkhead box protein R1", "gene_name": "Foxr1", "organism": "Mouse", "refseq_name": "forkhead box protein R1 isoform 2", "refseq_ac": "NP_001028641", "gene_names_uniprotkb": "Foxr1; Foxn5; Gm1115", "gene_names_refseq": "Foxn5; Foxr1; Gm1115", "protein_names_uniprotkb": "Forkhead box protein R1; Forkhead box protein N5", "protein_names_refseq": "forkhead box protein N5; forkhead box protein R1 isoform 2; forkhead box protein R1", "tax_id": 10090, "disease": "", "pathway": " (mmu:382074)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15289901;21750661;25428506;25609838;34723967", "class_list": "", "function": "Foxn5 was identified and characterized as a germ-line mutation., [RefSeq, PubMed]; Transcription factor which acts as both an activator and a repressor (By similarity). Activates transcription of a number of genes including the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 which are involved in protection against oxidative stress (By similarity). Required for normal brain development (PubMed:34723967)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UTB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60837-1", "uniprot_id": "I12R1_MOUSE", "mass": 81788.0, "length": 738, "protein_name": "Interleukin-12 receptor subunit beta-1", "gene_name": "Il12rb1", "organism": "Mouse", "refseq_name": "interleukin-12 receptor subunit beta-1 precursor", "refseq_ac": "NP_032379", "gene_names_uniprotkb": "Il12rb1; Il12rb", "gene_names_refseq": "CD212; IL-12R-beta-1; IL-12R[b]; Il12rb1", "protein_names_uniprotkb": "Interleukin-12 receptor subunit beta-1; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1", "protein_names_refseq": "IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component); interleukin-12 receptor subunit beta-1 precursor; interleukin-12 receptor subunit beta-1", "tax_id": 10090, "disease": "immunodeficiency 30 (Disease Ontology:DOID:0111990); primary biliary cholangitis (Disease Ontology:DOID:12236); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); allergic rhinitis (Disease Ontology:DOID:4481)", "pathway": " (mmu:16161); (R-MMU-9020591); (R-MMU-9020933)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;25404030;29123149;31219806;34637790;7594587;8943050", "class_list": "", "function": "Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Also associates with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade., [UniProtKB, UniProtKB, UniProtKB]; In summary, the receptor shuffling approach highlights an interchangeable, modular domain structure among IL-6- and IL-12-type cytokine receptors and enabled synthetic IL-35 and IL-39 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; The data support a model wherein IL12Rbeta1DeltaTM is a secreted product of il12rb1 that promotes resistance to M. tuberculosis infection by potentiating T(H) cells response to IL-12., [RefSeq, PubMed]; Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rbeta1 and subsequent signal transduction., [RefSeq, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 11, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q3UV59", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0004896 cytokine receptor activity;GO:0016517 interleukin-12 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0042022 interleukin-12 receptor complex;GO:0072536 interleukin-23 receptor complex", "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0051142 positive regulation of NK T cell proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0035722 interleukin-12-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q60837-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69ZN6-1", "uniprot_id": "GNPTA_MOUSE", "mass": 140984.0, "length": 1235, "protein_name": "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta", "gene_name": "Gnptab", "organism": "Mouse", "refseq_name": "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform 1", "refseq_ac": "NP_001004164", "gene_names_uniprotkb": "Gnptab; Gnpta; Kiaa1208", "gene_names_refseq": "EG432486; Gnptab", "protein_names_uniprotkb": "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; 2.7.8.17; GlcNAc-1-phosphotransferase subunits alpha/beta; Stealth protein GNPTAB; UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta", "protein_names_refseq": "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform 1; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; glcNAc-1-phosphotransferase subunits alpha/beta; stealth protein GNPTAB", "tax_id": 10090, "disease": "mucolipidosis II alpha/beta (Disease Ontology:DOID:0080070); mucolipidosis III alpha/beta (Disease Ontology:DOID:0080071); mucolipidosis (Disease Ontology:DOID:0080488); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:432486)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;16299590;17962477;19261645;21750661;34428180;39627609", "class_list": "glycogene", "function": "Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment., [UniProtKB, UniProtKB]; Retinal degeneration with storage disease phenotype in most exocrine glands in Gnptab null mice, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 13, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 13, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 13, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 72, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 4, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3K6;Q3US34", "ec_number_list": "2.7.8.17", "go_molecular_function": "GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity;GO:0005509 calcium ion binding;GO:0016740 transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0070622 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex", "go_biological_process": "GO:0007040 lysosome organization;GO:0009306 protein secretion;GO:0016256 N-glycan processing to lysosome;GO:0046835 carbohydrate phosphorylation;GO:0033299 secretion of lysosomal enzymes", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q69ZN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99L20-1", "uniprot_id": "GSTT3_MOUSE", "mass": 27403.0, "length": 241, "protein_name": "Glutathione S-transferase theta-3", "gene_name": "Gstt3", "organism": "Mouse", "refseq_name": "glutathione S-transferase theta-3 isoform 2", "refseq_ac": "NP_001333452", "gene_names_uniprotkb": "Gstt3", "gene_names_refseq": "Gstt3", "protein_names_uniprotkb": "Glutathione S-transferase theta-3; 2.5.1.18", "protein_names_refseq": "glutathione S-transferase theta-3 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:103140)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12038961;21750661", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows high activity towards 4-nitrobenzyl chloride (4-NBC). Also has lower activity towards 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP), cumene hydroperoxide, 1-chloro-2,4-dinitrobenzene (CDNB), 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl), and ethacrynic acid., [UniProtKB, PubMed]; Identification and characterization of GSTT3 [GSTT3], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6I4", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99L20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DFV6-1", "uniprot_id": "FN3C1_MOUSE", "mass": 149712.0, "length": 1356, "protein_name": "Fibronectin type III domain containing protein 3C1", "gene_name": "Fndc3c1", "organism": "Mouse", "refseq_name": "fibronectin type III domain containing protein 3C1", "refseq_ac": "NP_001007581", "gene_names_uniprotkb": "Fndc3c1; Fndc3c; Gm784", "gene_names_refseq": "Fndc3c1; Fndc3c; Gm784", "protein_names_uniprotkb": "Fibronectin type III domain containing protein 3C1", "protein_names_refseq": "fibronectin domain-containing protein 3c; fibronectin type III domain containing protein 3C1; fibronectin type III domain containing protein 3C", "tax_id": 10090, "disease": "", "pathway": " (mmu:333564)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16904100;21750661;25428506;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6DFV6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UJK4-1", "uniprot_id": "GTPB2_MOUSE", "mass": 65754.0, "length": 602, "protein_name": "GTP-binding protein 2", "gene_name": "Gtpbp2", "organism": "Mouse", "refseq_name": "GTP-binding protein 2 isoform 2", "refseq_ac": "NP_001139451", "gene_names_uniprotkb": "Gtpbp2", "gene_names_refseq": "Gtpbp2; nmf205", "protein_names_uniprotkb": "GTP-binding protein 2; GTP-binding-like protein 2", "protein_names_refseq": "GTP-binding protein 2 isoform 2; GTP-binding-like protein 2", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (mmu:56055); (R-MMU-114608)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10833435;11054535;21750661;25061210;25428506;25605945;30084848;30779550;34428180;35820727", "class_list": "", "function": "Involved in the rescue of ribosome stalling due to the presence of non-functional tRNA (PubMed:25061210). Has very low GTP-binding activity (By similarity)., [UniProtKB, UniProtKB, PubMed]; These results not only define GTPBP2 as a ribosome rescue factor but also unmask the disease potential of mutations in nuclear-encoded tRNA genes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9EST7;Q9JIX7", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:1904678 alpha-aminoacyl-tRNA binding", "go_cellular_component": "", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006414 translational elongation;GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3UJK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810H5-1", "uniprot_id": "GALP_MOUSE", "mass": 12773.0, "length": 117, "protein_name": "Galanin-like peptide", "gene_name": "Galp", "organism": "Mouse", "refseq_name": "galanin-like peptide preproprotein", "refseq_ac": "NP_821171", "gene_names_uniprotkb": "Galp", "gene_names_refseq": "Galp", "protein_names_uniprotkb": "Galanin-like peptide", "protein_names_refseq": "galanin-like peptide preproprotein", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:232836)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12746327;17535903;18617619;18775887;21647713;21750661;24055807;24796383;27323911", "class_list": "", "function": "Distinct expression of alarin, a splice variant of GALP, in the adult mouse brain demonstrates potential functions in reproduction and metabolism., [RefSeq, PubMed]; Exhibits antimicrobial activity against Gram-negative bacterias, inducing bacterial membrane blebbing (By similarity). Exhibits potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2., [UniProtKB, PubMed, PubMed]; GALP induces expression of IL-1 in the brain, and its anorexic and febrile actions are mediated by this cytokine acting via IL-1 type I receptor., [RefSeq, PubMed]; GALP may play a role in readjusting energy balance under changing nutritional circumstances, [RefSeq, PubMed]; Hypothalamic GALP gene expression is controlled by leptin signals, [RefSeq, PubMed]; Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion., [UniProtKB]; Results indicate the GALP ICV administration can further promote energy metabolism when administered to spontaneously exercising mice, [RefSeq, PubMed]; This study demonstrates anti-obesity effect of intranasal administration of galanin-like peptide in obese mice Publication Status: Online-Only, [RefSeq, PubMed]; We investigated whether PI3K signalling in neurones expressing GALP plays a role in the transcriptional regulation of the GALP gene, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5GXX4", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0042595 behavioral response to starvation;GO:0007218 neuropeptide signaling pathway;GO:0050829 defense response to Gram-negative bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0032098 regulation of appetite", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q810H5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYN5-1", "uniprot_id": "FSD1L_MOUSE", "mass": 56886.0, "length": 507, "protein_name": "FSD1-like protein", "gene_name": "Fsd1l", "organism": "Mouse", "refseq_name": "FSD1-like protein isoform 1", "refseq_ac": "NP_001182213", "gene_names_uniprotkb": "Fsd1l; Ccdc10; Csdufd1; Fsd1nl", "gene_names_refseq": "A230072O16Rik; Ccdc10; Csdufd1; Fsd1l; Fsd1nl", "protein_names_uniprotkb": "FSD1-like protein; Coiled-coil domain-containing protein 10; FSD1 N-terminal-like protein", "protein_names_refseq": "FSD1 N-terminal-like protein; FSD1-like protein isoform 1; FSD1-like protein; coiled-coil domain-containing protein 10; cystatin and DUF19 domain containing 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:319636)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20484733;21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3USW7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BYN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70291-1", "uniprot_id": "GRK4_MOUSE", "mass": 66928.0, "length": 574, "protein_name": "G protein-coupled receptor kinase 4", "gene_name": "Grk4", "organism": "Mouse", "refseq_name": "G protein-coupled receptor kinase 4 isoform 2", "refseq_ac": "NP_001074212", "gene_names_uniprotkb": "Grk4; Gprk2l", "gene_names_refseq": "A830025H08Rik; GRK; Gprk2l; Gprk4; Grk4", "protein_names_uniprotkb": "G protein-coupled receptor kinase 4; 2.7.11.16; G protein-coupled receptor kinase GRK4", "protein_names_refseq": "G protein-coupled receptor kinase 2, groucho gene related; G protein-coupled receptor kinase 4 isoform 2; g protein-coupled receptor kinase GRK4", "tax_id": 10090, "disease": "essential hypertension (Disease Ontology:DOID:10825); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:14772); (R-MMU-2514859)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10506199;15994203;19556343;21750661;36552750;36669643;37622333;37641972", "class_list": "", "function": "Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury., [RefSeq, PubMed]; Effect of GRK4 on renal gastrin receptor regulation in hypertension., [RefSeq, PubMed]; Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression., [RefSeq, PubMed]; GRK2 inhibits WNT signaling in osteoblasts, [RefSeq, PubMed]; LncRNA 148400 Promotes the Apoptosis of Renal Tubular Epithelial Cells in Ischemic AKI by Targeting the miR-10b-3p/GRK4 Axis. Publication Status: Online-Only, [RefSeq, PubMed]; Specifically phosphorylates the activated forms of G protein-coupled receptors., [UniProtKB]; The role of GRK2 in chronic ET-1-induced insulin resistance was investigated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V151", "ec_number_list": "2.7.11.16;2.7.11.-;2.7.11.15;2.7.11.14", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0050254 rhodopsin kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030425 dendrite", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0031623 receptor internalization;GO:0002031 G protein-coupled receptor internalization;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O70291-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01114-1", "uniprot_id": "IL9R_MOUSE", "mass": 52261.0, "length": 468, "protein_name": "Interleukin-9 receptor", "gene_name": "Il9r", "organism": "Mouse", "refseq_name": "interleukin-9 receptor isoform 2 precursor", "refseq_ac": "NP_032400", "gene_names_uniprotkb": "Il9r", "gene_names_refseq": "Il9r", "protein_names_uniprotkb": "Interleukin-9 receptor; IL-9 receptor; IL-9R", "protein_names_refseq": "IL-9 receptor; IL-9R; interleukin-9 receptor isoform 2 precursor", "tax_id": 10090, "disease": "cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:16199); (R-MMU-8985947)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1376929;2145361;21750661;26495903;36272280;36883978", "class_list": "", "function": "IL-9 stimulates an anti-tumor immune response and facilitates immune checkpoint blockade in the CMT167 mouse model., [RefSeq, PubMed]; Plays an important role in the immune response against parasites by acting as a receptor of IL9., [UniProtKB, PubMed]; Upregulated Expression of the IL-9 Receptor on TRAF3-Deficient B Lymphocytes Confers Ig Isotype Switching Responsiveness to IL-9 in the Presence of Antigen Receptor Engagement and IL-4., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004919 interleukin-9 receptor activity;GO:0019983 interleukin-9 binding;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0050730 regulation of peptidyl-tyrosine phosphorylation;GO:0030183 B cell differentiation;GO:0016064 immunoglobulin mediated immune response;GO:0042100 B cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q01114-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VIK3-1", "uniprot_id": "H18_MOUSE", "mass": 32223.0, "length": 304, "protein_name": "Histone H1.8", "gene_name": "H1.8; H1f8", "organism": "Mouse", "refseq_name": "histone H1.8 isoform 2", "refseq_ac": "NP_001333631", "gene_names_uniprotkb": "H1.8; H1f8; H1f8; H1foo; H1oo", "gene_names_refseq": "H1-8; H1.8; H1f8; H1foo; H1fo; H1oo", "protein_names_uniprotkb": "Histone H1.8; Histone H1oo; Oocyte-specific histone H1; Oocyte-specific linker histone H1", "protein_names_refseq": "H1 histone family, member O, oocyte-specific; histone H1.8 isoform 2; histone H1.8; histone H1oo; oocyte-specific histone H1; oocyte-specific linker histone H1", "tax_id": 10090, "disease": "", "pathway": " (mmu:171506)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11171391;12770723;14729479;15371275;17519519;21750661;36429134", "class_list": "", "function": "Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes and the encoded protein is expressed only in oocytes. [provided by RefSeq, Oct 2015]., [RefSeq]; May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure, [RefSeq, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The Oocyte-Specific Linker Histone H1FOO Is Not Essential for Mouse Oogenesis and Fertility. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0040029 epigenetic regulation of gene expression;GO:0045910 negative regulation of DNA recombination;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VIK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PB44-1", "uniprot_id": "PTN23_MOUSE", "mass": 185216.0, "length": 1692, "protein_name": "Tyrosine-protein phosphatase non-receptor type 23", "gene_name": "Ptpn23", "organism": "Mouse", "refseq_name": "tyrosine-protein phosphatase non-receptor type 23", "refseq_ac": "NP_001074512", "gene_names_uniprotkb": "Ptpn23; Kiaa1471", "gene_names_refseq": "PTP-TD14; Ptpn23", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 23; 3.1.3.48", "protein_names_refseq": "tyrosine-protein phosphatase non-receptor type 23", "tax_id": 10090, "disease": "", "pathway": " (mmu:104831)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "17242355;18250455;21183079;21750661;21913724;21952136;22645316;25428506;25428507;25605945;26495903;27669760;28011936;28528544;28620046;28935714;30084848;31219806;32079660;32782141;32848054;33725478;34418053;34428180;34678516;35984892;36210013;36852467;37828378;39627609;40021952;40885482;40997131", "class_list": "", "function": "PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (By similarity)., [UniProtKB]; The role of HD-PTP/PTPN23 in cancer and tumorigenesis is reviewed. Review article, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 15, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 15, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 15, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZJ0;Q8R1Z5;Q923E6", "ec_number_list": "3.1.3.48;3.1.3.2;3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.27;3.1.3.5;3.1.3.21;3.1.3.18", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:1903393 positive regulation of adherens junction organization;GO:0045022 early endosome to late endosome transport;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "Q6PB44-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RPY5-1", "uniprot_id": "GP161_MOUSE", "mass": 60303.0, "length": 545, "protein_name": "G protein-coupled receptor 161", "gene_name": "Gpr161", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 161 isoform 1", "refseq_ac": "NP_001074595", "gene_names_uniprotkb": "Gpr161; Gm208", "gene_names_refseq": "Gm208Gpr; Gm208; Gpr161; vl", "protein_names_uniprotkb": "G protein-coupled receptor 161", "protein_names_refseq": "G-protein coupled receptor 161 isoform 1", "tax_id": 10090, "disease": "medulloblastoma (Disease Ontology:DOID:0050902)", "pathway": " (mmu:240888); (R-MMU-5610787); (R-MMU-5632684)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "12679517;18250320;21750661;23332756;27357676;29222391;29386106;30914320;34346313;38326651;39369306;40737401", "class_list": "", "function": "G protein-coupled receptor that acts as a key inhibitor of the smoothened signaling pathway in primary cilia (PubMed:23332756, PubMed:27357676, PubMed:29386106, PubMed:34346313, PubMed:38326651, PubMed:40737401). Inhibits the smoothened signaling pathway in absence of hedgehog (DHH, IHH or SHH) by promoting formation of the transcription repressor form of GLI2 and GLI3 transcription factors (PubMed:23332756, PubMed:27357676, PubMed:29386106, PubMed:34346313, PubMed:40737401). GPR161 activation triggers signaling via guanine nucleotide-binding protein G(s)/GNAS, mediating activation of adenylate cyclase activity and production of cAMP (PubMed:23332756, PubMed:34346313, PubMed:40737401). Increased cAMP levels activate PKA, promoting PKA-dependent processing of GLI2 and GLI3 transcription factors, leading to formation of transcription repressor GLI2R and GLI3R, which repress expression of target genes (PubMed:23332756). GPR161 also activates PKA by acting as a PKA-anchoring protein, which directly associates with type I PKA regulatory subunits (PRKAR1A and/or PRKAR1B), recruiting PKA followed by PKA-dependent processing of GLI2 and GLI3 transcription factors (PubMed:27357676, PubMed:38326651). In presence of hedgehog, GPR161 is removed from primary cilia by smoothened (SMO), preventing its activity and allowing activation of the smoothened signaling (PubMed:23332756). In contrast to the majority of G protein-coupled receptors, it is not activated by a ligand and it either acts as a constitutively active receptor or as a mechanosensitive receptor (PubMed:23332756, PubMed:40737401). Involved in regulation of the smoothened signaling pathway during early neural tube development, forelimb formation, skeletal development, embryonic cerebellar development and forebrain development (PubMed:18250320, PubMed:29222391, PubMed:29386106, PubMed:30914320). Involved in the saltatory migration of neurons during brain development by acting as a mechanosensitive receptor that senses mechanical forces generated by fluid shear stress (PubMed:40737401)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown., [UniProtKB, UniProtKB]; Linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse neural tube development., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B0L0L8;J3QN69;Q80T48", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005929 cilium;GO:0055037 recycling endosome;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "B2RPY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGG6-1", "uniprot_id": "GNL3L_MOUSE", "mass": 65195.0, "length": 577, "protein_name": "Guanine nucleotide-binding protein-like 3-like protein", "gene_name": "Gnl3l", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein-like 3-like protein", "refseq_ac": "NP_001162071", "gene_names_uniprotkb": "Gnl3l", "gene_names_refseq": "Gnl3l", "protein_names_uniprotkb": "Guanine nucleotide-binding protein-like 3-like protein", "protein_names_refseq": "guanine nucleotide binding protein-like 3 (nucleolar)-like; guanine nucleotide-binding protein-like 3-like protein", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:237107)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17623774;19487455;21132010;21750661;38022822", "class_list": "", "function": "GNL3L mediates the mitotic increase of TRF1 protein and promotes the metaphase-to-anaphase transition., [RefSeq, PubMed]; Knockdown of GNL3L Alleviates the Progression of COPD Through Inhibiting the ATM/p53 Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity)., [UniProtKB, PubMed, PubMed]; Work reveals a novel mechanism that negatively regulates the transcriptional function of ERRgamma (estrogen-related receptor)by GNL3L through coactivator competition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:1904816 positive regulation of protein localization to chromosome, telomeric region;GO:0031334 positive regulation of protein-containing complex assembly;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0042254 ribosome biogenesis;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PGG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99L00-1", "uniprot_id": "HAUS8_MOUSE", "mass": 41653.0, "length": 373, "protein_name": "HAUS augmin-like complex subunit 8", "gene_name": "Haus8", "organism": "Mouse", "refseq_name": "HAUS augmin-like complex subunit 8 isoform 1", "refseq_ac": "NP_001156514", "gene_names_uniprotkb": "Haus8; Hice1", "gene_names_refseq": "2410004L22Rik; Haus8; Hice1", "protein_names_uniprotkb": "HAUS augmin-like complex subunit 8; HEC1/NDC80-interacting centrosome-associated protein 1; Sarcoma antigen NY-SAR-48 homolog", "protein_names_refseq": "HAUS augmin-like complex subunit 8 isoform 1; HAUS augmin-like complex subunit 8; HEC1/NDC80 interacting, centrosome associated 1; HEC1/NDC80-interacting centrosome-associated protein 1; sarcoma antigen NY-SAR-48 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:76478); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWT4", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0070652 HAUS complex;GO:1990498 mitotic spindle microtubule", "go_biological_process": "GO:0051301 cell division;GO:0007098 centrosome cycle;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99L00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CY28-1", "uniprot_id": "GTPB8_MOUSE", "mass": 31872.0, "length": 285, "protein_name": "GTP-binding protein 8", "gene_name": "Gtpbp8", "organism": "Mouse", "refseq_name": "GTP-binding protein 8 isoform 2", "refseq_ac": "NP_001152801", "gene_names_uniprotkb": "Gtpbp8", "gene_names_refseq": "0610037H22Rik; Gtpbp8", "protein_names_uniprotkb": "GTP-binding protein 8", "protein_names_refseq": "GTP-binding protein 8 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66067)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;22872234;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNM0", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CY28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Z53-1", "uniprot_id": "GRHPR_MOUSE", "mass": 35329.0, "length": 328, "protein_name": "Glyoxylate reductase/hydroxypyruvate reductase", "gene_name": "Grhpr", "organism": "Mouse", "refseq_name": "glyoxylate reductase/hydroxypyruvate reductase isoform 1", "refseq_ac": "NP_525028", "gene_names_uniprotkb": "Grhpr; Glxr", "gene_names_refseq": "1110059D05Rik; 6430629L09Rik; Glxr; Grhpr", "protein_names_uniprotkb": "Glyoxylate reductase/hydroxypyruvate reductase; 1.1.1.79; 1.1.1.81", "protein_names_refseq": "glyoxylate reductase/hydroxypyruvate reductase isoform 1", "tax_id": 10090, "disease": "primary hyperoxaluria type 2 (Disease Ontology:DOID:0111671); primary hyperoxaluria (Disease Ontology:DOID:2977)", "pathway": " (mmu:76238); (R-MMU-389661)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15840574;21750661;26997491;31219806;33300544;34428180;36288343;37453647", "class_list": "", "function": "Data indicate a species-specific regulation by PPARalpha of GRHPR, a key gene of the glyoxylate cycle, [RefSeq, PubMed]; Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate (By similarity)., [UniProtKB]; These data suggested that GRHPR might exert its pro-apoptosis function in intestinal epithelial cells. Thus, GRHPR might play an important role in regulating IECs apoptosis, and might be a potential therapeutic target for Crohn's disease., [RefSeq, PubMed]; This gene encodes a member of the D-isomer specific 2-hydroxyacid dehydrogenase family of proteins. The encoded protein catalyzes three enzymatic reactions: the conversion of hydroxypyruvate to D-glycerate as well as the reverse reaction, and the conversion of glyoxylate to glycolate. Homozygous knockout mice exhibit elevated synthesis of oxalate and glycerate. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.79;1.1.1.81", "go_molecular_function": "GO:0008465 hydroxypyruvate reductase (NADH) activity;GO:0016618 hydroxypyruvate reductase [NAD(P)H] activity;GO:0030267 glyoxylate reductase (NADPH) activity;GO:0042803 protein homodimerization activity;GO:0051287 NAD binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1902494 catalytic complex", "go_biological_process": "GO:0043648 dicarboxylic acid metabolic process;GO:0046487 glyoxylate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q91Z53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CAL5-1", "uniprot_id": "GPC5_MOUSE", "mass": 63792.0, "length": 572, "protein_name": "Glypican-5", "gene_name": "Gpc5", "organism": "Mouse", "refseq_name": "glypican-5 precursor", "refseq_ac": "NP_780709", "gene_names_uniprotkb": "Gpc5", "gene_names_refseq": "A230034F01Rik; Gpc5", "protein_names_uniprotkb": "Glypican-5", "protein_names_refseq": "glypican-5 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:103978); (R-MMU-1971475); (R-MMU-2022928); (R-MMU-2024096); (R-MMU-5362798); (R-MMU-975634); (R-MMU-9769735); (R-MMU-9769739)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506", "class_list": "glycogene", "function": "Cell surface proteoglycan that bears heparan sulfate., [UniProtKB]; Cell surface proteoglycan., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 3, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q14BN1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0016477 cell migration;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:1905475 regulation of protein localization to membrane;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CAL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PB97-1", "uniprot_id": "FXL19_MOUSE", "mass": 73788.0, "length": 674, "protein_name": "F-box/LRR-repeat protein 19", "gene_name": "Fbxl19", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 19 isoform 1", "refseq_ac": "NP_766336", "gene_names_uniprotkb": "Fbxl19", "gene_names_refseq": "6030430O11; Fbl19; Fbxl19", "protein_names_uniprotkb": "F-box/LRR-repeat protein 19; F-box and leucine-rich repeat protein 19", "protein_names_refseq": "F-box/LRR-repeat protein 19 isoform 1; F-box/LRR-repeat protein 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:233902); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21750661;22660580;28453857;29809150;31488578;31996894;34428180;36964598", "class_list": "", "function": "FBXL19 and CDK-Mediator support long-range interactions between silent gene promoters that rely on FBXL19 for their induction during differentiation and gene regulatory elements., [RefSeq, PubMed]; Protective role of FBXL19 in Streptococcus pneumoniae-induced lung injury in pneumonia immature mice. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization (PubMed:28453857, PubMed:29809150). Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner. Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration. Also mediates ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis (PubMed:22660580). Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:28453857, PubMed:29809150). Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation (PubMed:29809150). In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination (PubMed:28453857)., [UniProtKB, UniProtKB, PubMed, PubMed]; These data validate Fbxl19 as a direct miR-26 target and support its role as a regulator of adipogenesis that functions downstream from the miR-26 familywithin the APC lineage, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSH0;Q8BIB4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0032452 histone demethylase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0045322 unmethylated CpG binding", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016477 cell migration;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6PB97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BRM2-1", "uniprot_id": "GORAB_MOUSE", "mass": 41487.0, "length": 368, "protein_name": "RAB6-interacting golgin", "gene_name": "Gorab", "organism": "Mouse", "refseq_name": "RAB6-interacting golgin isoform 2", "refseq_ac": "NP_001300667", "gene_names_uniprotkb": "Gorab; Ntklbp1; Scyl1bp1", "gene_names_refseq": "Gorab; NTKL-BP1; SCYL1-BP1; Scyl1bp1", "protein_names_uniprotkb": "RAB6-interacting golgin; N-terminal kinase-like-binding protein 1; NTKL-BP1; NTKL-binding protein 1; SCY1-like 1-binding protein 1; SCYL1-BP1; SCYL1-binding protein 1; mNTKL-BP1", "protein_names_refseq": "N-terminal kinase-like-binding protein 1; NTKL-binding protein 1; RAB6-interacting golgin isoform 2; RAB6-interacting golgin; SCY1-like 1 binding protein 1; SCYL1-binding protein 1", "tax_id": 10090, "disease": "geroderma osteodysplasticum (Disease Ontology:DOID:0111266)", "pathway": " (mmu:98376)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12783284;18094236;18997784;21750661;29561836;30631079;32067289;32848054;40885482", "class_list": "", "function": "GORAB promotes embryonic lung maturation through antagonizing AKT phosphorylation, versican expression, and mesenchymal cell migration., [RefSeq, PubMed]; Gorab role in the abnormal osteoblast differentiation in the gerodermia osteodysplastica Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the organization and function of the Golgi apparatus. Involved in protein post-translational modification, particularly glycosylation of extracellular matrix proteins. Functions at the trans-Golgi by cooperating with SCYL1 to promote COPI coat assembly into discrete functional domains, supporting Golgi organization and trafficking., [UniProtKB, PubMed, PubMed]; The G59S mutation in p150(glued) protein abrogates the normal function of the protein and accelerates motor neuron degeneration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CAA8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:1905515 non-motile cilium assembly;GO:0031069 hair follicle morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BRM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTK3-1", "uniprot_id": "GPAA1_MOUSE", "mass": 67949.0, "length": 621, "protein_name": "GPI-anchor transamidase component GPAA1", "gene_name": "Gpaa1", "organism": "Mouse", "refseq_name": "GPI-anchor transamidase component GPAA1", "refseq_ac": "NP_034461", "gene_names_uniprotkb": "Gpaa1; Gaa1", "gene_names_refseq": "Gpaa1; mGAA1", "protein_names_uniprotkb": "GPI-anchor transamidase component GPAA1; GAA1 protein homolog; GPI anchor attachment protein 1; Glycosylphosphatidylinositol anchor attachment 1 protein; mGAA1", "protein_names_refseq": "GAA1 protein homolog; GPI-anchor transamidase component GPAA1; glycosylphosphatidylinositol anchor attachment 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:14731); (R-MMU-162791)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10393431;10793132;10898732;14660601;21750661;25428506;30084848;34428180", "class_list": "glycogene", "function": "A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol recognition by GPI transamidase, [RefSeq, PubMed]; Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis (PubMed:10793132, PubMed:10898732). Binds GPI-anchor (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 35, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNU9;Q9R1U8", "ec_number_list": "", "go_molecular_function": "GO:0034235 GPI anchor binding;GO:0003923 GPI-anchor transamidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein;GO:0180046 GPI anchored protein biosynthesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WTK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZPV2-1", "uniprot_id": "INO80_MOUSE", "mass": 176520.0, "length": 1559, "protein_name": "Chromatin-remodeling ATPase INO80", "gene_name": "Ino80", "organism": "Mouse", "refseq_name": "chromatin-remodeling ATPase INO80", "refseq_ac": "NP_080850", "gene_names_uniprotkb": "Ino80; Inoc1; Kiaa1259", "gene_names_refseq": "2310079N15Rik; 4632409L19Rik; Ino80; Inoc1", "protein_names_uniprotkb": "Chromatin-remodeling ATPase INO80; 3.6.4.-; DNA helicase-related INO80 complex homolog 1; DNA helicase-related protein INO80", "protein_names_refseq": "DNA helicase INO80; DNA helicase-related INO80 complex homolog 1; DNA helicase-related protein INO80; INO80 complex subunit A; chromatin-remodeling ATPase INO80; putative DNA helicase INO80 complex homolog 1; yeast INO80-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68142); (R-MMU-5689603); (R-MMU-5696394)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "16298340;18026119;20971067;21750661;25428506;30084848;31219806;34428180;35006254;36210013;39405305", "class_list": "", "function": "ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair., [UniProtKB, UniProtKB]; ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle., [UniProtKB, UniProtKB]; INO80 regulates chromatin accessibility to facilitate suppression of sex-linked gene expression during mouse spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes. Erratum:[Development. 2023 Jul 15;150(14):dev202158. doi: 10.1242/dev.202158. PMID: 37449853], [RefSeq, PubMed]; Observations reveal a link between YY1 and INO80 and roles for both in homologous recombination-based repair, providing new insight into mechanisms that control the cellular response to genotoxic stress, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AQP8;Q6P7V0;Q6PCP1;Q8C9T7", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.4.-.-;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;1.14.11.-;3.6.5.-;2.3.2.32;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3;3.4.19.12", "go_molecular_function": "GO:0003677 DNA binding;GO:0003779 actin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6ZPV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03142-1", "uniprot_id": "FGFR4_MOUSE", "mass": 88661.0, "length": 799, "protein_name": "Fibroblast growth factor receptor 4", "gene_name": "Fgfr4", "organism": "Mouse", "refseq_name": "fibroblast growth factor receptor 4 precursor", "refseq_ac": "NP_032037", "gene_names_uniprotkb": "Fgfr4; Fgfr-4; Mpk-11", "gene_names_refseq": "Fgfr-4; Fgfr4", "protein_names_uniprotkb": "Fibroblast growth factor receptor 4; 2.7.10.1; FGFR-4; Protein-tyrosine kinase receptor MPK-11", "protein_names_refseq": "CTLA-2-beta protein; fibroblast growth factor receptor 4 16 minus form; fibroblast growth factor receptor 4 precursor; protein-tyrosine kinase receptor MPK-11", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); bone disease (Disease Ontology:DOID:0080001); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); colon cancer (Disease Ontology:DOID:219); high grade glioma (Disease Ontology:DOID:3070); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); liver cirrhosis (Disease Ontology:DOID:5082); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:14186); (R-MMU-109704); (R-MMU-1257604); (R-MMU-1307965); (R-MMU-190322); (R-MMU-5654228); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5654720); (R-MMU-5654733); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 12, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10809780;1281307;1723680;17452648;17664243;18186042;19237543;19656770;21561999;21750661;26675719;35820727;9716527", "class_list": "glycogene", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Plays a role in postnatal lung development. May be involved in the development of skeletal muscle cell lineages., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 43, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q27Q87;Q5J7D9;Q8C3V5;Q8CIB8", "ec_number_list": "2.7.12.2;2.7.10.1;3.2.1.31;2.7.12.1;2.7.1.153;2.7.1.137;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;3.6.5.2;2.7.11.17;3.2.2.6;3.1.3.48;2.3.2.27;2.7.11.13;2.7.10.4;2.7.1.40;2.7.11.24;2.7.11.23;3.1.4.11;2.7.1.154", "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0008201 heparin binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0070857 regulation of bile acid biosynthetic process;GO:0001759 organ induction;GO:0010966 regulation of phosphate transport;GO:0051174 regulation of phosphorus metabolic process;GO:0061144 alveolar secondary septum development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q03142-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51855-1", "uniprot_id": "GSHB_MOUSE", "mass": 52247.0, "length": 474, "protein_name": "Glutathione synthetase", "gene_name": "Gss", "organism": "Mouse", "refseq_name": "glutathione synthetase isoform a", "refseq_ac": "NP_032206", "gene_names_uniprotkb": "Gss", "gene_names_refseq": "GS-A/GS-B; GSH-S; Gss", "protein_names_uniprotkb": "Glutathione synthetase; 6.3.2.3; GSH synthetase; GSH-S; Glutathione synthase", "protein_names_refseq": "GSH synthetase; glutathione synthase; glutathione synthetase isoform a", "tax_id": 10090, "disease": "glutathione synthetase deficiency (Disease Ontology:DOID:0080699); glutatione synthetase deficiency with 5-oxoprolinuria (Disease Ontology:DOID:0081034); congenital nonspherocytic hemolytic anemia 6 (Disease Ontology:DOID:0112252); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:14854); (R-MMU-174403)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;16608839;20128681;21750661;34428180;37184393;37453647;37507081;38114454;8660701", "class_list": "", "function": "Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes. Participates in ophthalmate biosynthesis in hepatocytes (PubMed:16608839)., [UniProtKB, UniProtKB, PubMed]; Cystine/Glutamate Xc[-] Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis., [RefSeq, PubMed]; Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice. Publication Status: Online-Only, [RefSeq, PubMed]; Hypoxia decreased 2 key enzyme activities that regulate GSH synthesis, glutamate cysteine ligase (GCL) (E.C. 6.3.2.2) and glutathione synthase (GS) (E.C. 6.3.2.3), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.3.2.3", "go_molecular_function": "GO:0004363 glutathione synthase activity;GO:0043295 glutathione binding;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0046686 response to cadmium ion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P51855-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCQ3-1", "uniprot_id": "GOT1A_MOUSE", "mass": 14800.0, "length": 133, "protein_name": "Vesicle transport protein GOT1A", "gene_name": "Golt1a", "organism": "Mouse", "refseq_name": "vesicle transport protein GOT1A", "refseq_ac": "NP_080956", "gene_names_uniprotkb": "Golt1a", "gene_names_refseq": "0610012C01Rik; Golt1a; Kiss1; metastatin", "protein_names_uniprotkb": "Vesicle transport protein GOT1A; Golgi transport 1 homolog A", "protein_names_refseq": "vesicle transport protein GOT1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68338)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;22132116;34428180", "class_list": "", "function": "Kisspeptin and its receptor are expressed in the human, rat and mouse heart and kisspeptins possess potent positive inotropic activity., [RefSeq, PubMed]; May be involved in fusion of ER-derived transport vesicles with the Golgi complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DCQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35660-1", "uniprot_id": "GSTM6_MOUSE", "mass": 25621.0, "length": 218, "protein_name": "Glutathione S-transferase Mu 6", "gene_name": "Gstm6", "organism": "Mouse", "refseq_name": "glutathione S-transferase Mu 6 isoform 4", "refseq_ac": "NP_032210", "gene_names_uniprotkb": "Gstm6; Gstm5", "gene_names_refseq": "Gstm6", "protein_names_uniprotkb": "Glutathione S-transferase Mu 6; 2.5.1.18; GST class-mu 6; Glutathione-S-transferase class M5", "protein_names_refseq": "GST class-mu 6; glutathione S-transferase Mu 6 isoform 4; glutathione S-transferase Mu 6; glutathione-S-transferase class M5", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); bacterial sepsis (Disease Ontology:DOID:0040085); Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); inflammatory bowel disease (Disease Ontology:DOID:0050589); chorioamnionitis (Disease Ontology:DOID:0050697); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); stroke (Disease Ontology:DOID:0051061); pre-malignant neoplasm (Disease Ontology:DOID:0060071); drug allergy (Disease Ontology:DOID:0060500); alcohol-associated liver disease (Disease Ontology:DOID:0070658); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); colorectal carcinoma (Disease Ontology:DOID:0080199); erythema nodosum (Disease Ontology:DOID:0080750); graft-versus-host disease (Disease Ontology:DOID:0081267); osteonecrosis (Disease Ontology:DOID:10159); thalassemia (Disease Ontology:DOID:10241); prostate cancer (Disease Ontology:DOID:10283); asbestosis (Disease Ontology:DOID:10320); lymphoid leukemia (Disease Ontology:DOID:1037); esophageal atresia (Disease Ontology:DOID:10485); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); primary open angle glaucoma (Disease Ontology:DOID:1070); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); head and neck cancer (Disease Ontology:DOID:11934); allergic disease (Disease Ontology:DOID:1205); optic neuritis (Disease Ontology:DOID:1210); malaria (Disease Ontology:DOID:12365); aplastic anemia (Disease Ontology:DOID:12449); autistic disorder (Disease Ontology:DOID:12849); uterine fibroid (Disease Ontology:DOID:13223); lung cancer (Disease Ontology:DOID:1324); mesenteric vascular occlusion (Disease Ontology:DOID:13252); angle-closure glaucoma (Disease Ontology:DOID:13550); Fanconi anemia (Disease Ontology:DOID:13636); exfoliation syndrome (Disease Ontology:DOID:13641); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); aggressive periodontitis (Disease Ontology:DOID:1474); cystic fibrosis (Disease Ontology:DOID:1485); urticaria (Disease Ontology:DOID:1555); acute chest syndrome (Disease Ontology:DOID:1584); depressive disorder (Disease Ontology:DOID:1596); keratosis (Disease Ontology:DOID:161); breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682); malignant mesothelioma (Disease Ontology:DOID:1790); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); ovary epithelial cancer (Disease Ontology:DOID:2152); multiple sclerosis (Disease Ontology:DOID:2377); larynx cancer (Disease Ontology:DOID:2596); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); cervix carcinoma (Disease Ontology:DOID:2893); acute pancreatitis (Disease Ontology:DOID:2913); pulmonary tuberculosis (Disease Ontology:DOID:2957); adenocarcinoma (Disease Ontology:DOID:299); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gallbladder cancer (Disease Ontology:DOID:3121); porphyria cutanea tarda (Disease Ontology:DOID:3132); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); toxic encephalopathy (Disease Ontology:DOID:3602); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pleural empyema (Disease Ontology:DOID:3798); Lynch syndrome (Disease Ontology:DOID:3883); gastritis (Disease Ontology:DOID:4029); bacterial gastritis (Disease Ontology:DOID:4033); systemic scleroderma (Disease Ontology:DOID:418); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); movement disease (Disease Ontology:DOID:480); small intestine adenocarcinoma (Disease Ontology:DOID:4906); esophagus adenocarcinoma (Disease Ontology:DOID:4914); cholangiocarcinoma (Disease Ontology:DOID:4947); esophageal cancer (Disease Ontology:DOID:5041); melioidosis (Disease Ontology:DOID:5052); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); schizophrenia (Disease Ontology:DOID:5419); oral submucous fibrosis (Disease Ontology:DOID:5773); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); leukopenia (Disease Ontology:DOID:615); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); Hodgkin's lymphoma (Disease Ontology:DOID:8567); infectious mononucleosis (Disease Ontology:DOID:8568); ulcerative colitis (Disease Ontology:DOID:8577); oral cavity cancer (Disease Ontology:DOID:8618); myeloid leukemia (Disease Ontology:DOID:8692); bacterial pneumonia (Disease Ontology:DOID:874); Crohn's disease (Disease Ontology:DOID:8778); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); polycythemia vera (Disease Ontology:DOID:8997); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); amyloidosis (Disease Ontology:DOID:9120); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:14867); (R-MMU-156590); (R-MMU-9748787); (R-MMU-9753281)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21750661;34428180;9480867", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 129, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35661;Q8K0C3", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35660-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99NI3-1", "uniprot_id": "GT2D2_MOUSE", "mass": 104578.0, "length": 936, "protein_name": "General transcription factor II-I repeat domain-containing protein 2", "gene_name": "Gtf2ird2", "organism": "Mouse", "refseq_name": "general transcription factor II-I repeat domain-containing protein 2 isoform 1", "refseq_ac": "NP_444496", "gene_names_uniprotkb": "Gtf2ird2", "gene_names_refseq": "1700012P16Rik; Gtf2ird2", "protein_names_uniprotkb": "General transcription factor II-I repeat domain-containing protein 2; GTF2I repeat domain-containing protein 2; Transcription factor GTF2IRD2", "protein_names_refseq": "GTF2I repeat domain-containing protein 2; general transcription factor II-I repeat domain-containing protein 2 isoform 1; general transcription factor II-I repeat domain-containing protein 2; transcription factor GTF2IRD2", "tax_id": 10090, "disease": "", "pathway": " (mmu:114674)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15100712;15243160;17823943;21750661;22899722;34428180", "class_list": "", "function": "Expression of TFII-I gene family were mapped in embryonic tooth germs; at bud stage, Gtf2ird1 & Gtf2ird2 were expressed in epithelial buds; at early bell stage, expression of Gtf2ird1 & Gtf2ird2 was observed in preameloblasts & preodontoblasts, [RefSeq, PubMed]; GTF2IRD2 has evolved as a regulator of GTF2IRD1 and TFII-I; inhibiting their function by direct interaction and sequestration into inactive nuclear zones., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0014883 transition between fast and slow fiber", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99NI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIF3-1", "uniprot_id": "SL2A8_MOUSE", "mass": 51508.0, "length": 477, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 8", "gene_name": "Slc2a8", "organism": "Mouse", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 8 isoform 1 precursor", "refseq_ac": "NP_062361", "gene_names_uniprotkb": "Slc2a8; Glut8; GlutX1", "gene_names_refseq": "D2Ertd44e; GLUT8; GlutX1; Slc2a8", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 8; GLUT-8; Glucose transporter type 8; Glucose transporter type X1", "protein_names_refseq": "GLUT-8; glucose transporter X1; glucose transporter type 8; glucose transporter type X1; intestinal GLUT8 transporter; solute carrier family 2, facilitated glucose transporter member 8 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:56017); (R-MMU-189200); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10671487;10821868;10860996;11689004;11845330;16723738;21750661;23396969;27922102;35123128", "class_list": "glycogene", "function": "Crosstalk between TM4SF5 and GLUT8 regulates fructose metabolism in hepatic steatosis., [RefSeq, PubMed]; Genomic organization, promoter region, and regulation of expression in 3T3-L1 cells by glucose, [RefSeq, PubMed]; Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (PubMed:10821868, PubMed:10860996, PubMed:23396969). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1 (PubMed:27922102). Also able to mediate the transport of dehydroascorbate (PubMed:23396969)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The mRNA synthesis of this carrier protein during the maturation of the mouse testis coincides with the appearance of mature spermatozoa., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKP8;Q9JJP4;Q9JJZ0", "ec_number_list": "", "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005353 fructose transmembrane transporter activity;GO:0005536 D-glucose binding;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0001666 response to hypoxia;GO:0006006 glucose metabolic process;GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JIF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923K4-1", "uniprot_id": "GTPB3_MOUSE", "mass": 52175.0, "length": 492, "protein_name": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial", "gene_name": "Gtpbp3", "organism": "Mouse", "refseq_name": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial precursor", "refseq_ac": "NP_115933", "gene_names_uniprotkb": "Gtpbp3", "gene_names_refseq": "2410009F13Rik; Gtpbp3", "protein_names_uniprotkb": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial; 3.6.1.-; GTP-binding protein 3; tRNA modification GTPase GTPBP3, mitochondrial", "protein_names_refseq": "5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial precursor; 5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial; tRNA modification GTPase GTPBP3, mitochondrial", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 23 (Disease Ontology:DOID:0111500); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:70359)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14680828;21750661", "class_list": "", "function": "GTPase component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation. Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity., [UniProtKB, UniProtKB]; These observations suggest that the mouse Gtpbp3 is an evolutionarily conserved mitochondrial GTP-binding protein involved in the tRNA modification., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58E73;Q99M99", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0160236 tRNA 5-taurinomethyluridine synthase activity", "go_cellular_component": "GO:1990234 transferase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:7770010 GTPBP3-MTO1 complex", "go_biological_process": "GO:0002098 tRNA wobble uridine modification;GO:0030488 tRNA methylation;GO:0070899 mitochondrial tRNA wobble uridine modification;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q923K4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60934-1", "uniprot_id": "GRIK1_MOUSE", "mass": 95202.0, "length": 836, "protein_name": "Glutamate receptor ionotropic, kainate 1", "gene_name": "Grik1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Grik1; Glur5", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutamate receptor ionotropic, kainate 1; GluK1; GluR-5; GluR5; Glutamate receptor 5", "protein_names_refseq": "", "tax_id": 10090, "disease": "status epilepticus (Disease Ontology:DOID:1824); childhood absence epilepsy (Disease Ontology:DOID:1825)", "pathway": " (mmu:14805); (R-MMU-451307); (R-MMU-451308)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;1717158;21750661;8260617;8700852", "class_list": "", "function": "Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist., [UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 9, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0042802 identical protein binding;GO:0097110 scaffold protein binding;GO:0000149 SNARE binding;GO:0004970 glutamate-gated receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0007399 nervous system development;GO:0030534 adult behavior;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q60934-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35412-1", "uniprot_id": "GPR12_MOUSE", "mass": 36589.0, "length": 334, "protein_name": "G protein-coupled receptor 12", "gene_name": "Gpr12", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 12 isoform a", "refseq_ac": "NP_001010941", "gene_names_uniprotkb": "Gpr12; Gpcr12", "gene_names_refseq": "Gpcr01; Gpcr12; Gpcr20; Gpcr21; Gpr12", "protein_names_uniprotkb": "G protein-coupled receptor 12; GPCR01", "protein_names_refseq": "G-protein coupled receptor 12 isoform a", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14738)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12574419;16229830;16887097;21750661;22879962;32997977;8262253", "class_list": "", "function": "A Thalamic Orphan Receptor Drives Variability in Short-Term Memory., [RefSeq, PubMed]; Brain-specific G protein-coupled receptor involved in regulating diverse physiological processes including neurite outgrowth, meiotic arrest, and lipid and carbohydrate metabolism (PubMed:16229830, PubMed:16887097). Functions as a receptor with constitutive G(s)-mediated signaling activity that stimulates cyclic AMP (cAMP) production. Also engages the G(i)/G(o) pathway, which counteracts the cAMP increase driven by G(s) activation. Additionally, two lipids sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) may act as endogenous ligand and activate GPR12 (PubMed:12574419)., [UniProtKB, PubMed, PubMed, PubMed]; GPCR12 is considered important for the energy balance since GPCR12 KO mice develop obesity and have lower energy expenditure., [RefSeq, PubMed]; Studying metabolic and emotionality parameters in Gpr12 mutant mice did not reveal a major phenotypic impact of the gene mutation., [RefSeq, PubMed]; The cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P35412-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61148-1", "uniprot_id": "FGF1_MOUSE", "mass": 17418.0, "length": 155, "protein_name": "Fibroblast growth factor 1", "gene_name": "Fgf1", "organism": "Mouse", "refseq_name": "fibroblast growth factor 1", "refseq_ac": "NP_034327", "gene_names_uniprotkb": "Fgf1; Fgf-1; Fgfa", "gene_names_refseq": "Dffrx; Fam; Fgf-1; Fgf1; Fgf2b; Fgfa", "protein_names_uniprotkb": "Fibroblast growth factor 1; Acidic fibroblast growth factor; FGF-1; HBGF-1; Heparin-binding growth factor 1; aFGF", "protein_names_refseq": "HBGF-1; aFGF; acidic fibroblast growth factor; fibroblast growth factor 1 (acidic); fibroblast growth factor 1; fibroblast growth factor 2b; heparin-binding growth factor 1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); leiomyoma (Disease Ontology:DOID:127); endometrial cancer (Disease Ontology:DOID:1380); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (mmu:14164); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190322); (R-MMU-190370); (R-MMU-190371); (R-MMU-190372); (R-MMU-190373); (R-MMU-190375); (R-MMU-190377); (R-MMU-5654219); (R-MMU-5654221); (R-MMU-5654227); (R-MMU-5654228); (R-MMU-5654687); (R-MMU-5654688); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654710); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5654720); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 33, "publication_count": 6, "publication_id_list": "21750661;2318343;24447999;39320918;8939980;8972905", "class_list": "glycogene", "function": "Paracrine FGF1 signaling directs pituitary architecture and size., [RefSeq, PubMed]; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 1, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 1, "secondary_ac_list": "P10935", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0044548 S100 protein binding;GO:0008083 growth factor activity;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0001759 organ induction;GO:1903672 positive regulation of sprouting angiogenesis;GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P61148-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42867-1", "uniprot_id": "GPT_MOUSE", "mass": 46412.0, "length": 410, "protein_name": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase", "gene_name": "Dpagt1", "organism": "Mouse", "refseq_name": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform 1", "refseq_ac": "NP_031901", "gene_names_uniprotkb": "Dpagt1; Dpagt2; Gnpta", "gene_names_refseq": "Dpagt1; Dpagt2; G1PT; GPT; Gnpta", "protein_names_uniprotkb": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; 2.7.8.15; G1PT; GPT; GlcNAc-1-P transferase; N-acetylglucosamine-1-phosphate transferase", "protein_names_refseq": "N-acetylglucosamine-1-phosphate transferase; UDP-N-acetylglucosamine lysosomal enzyme N-acetylglucosamine phosphotransferase; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform 1; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase); dolichyl-phosphate alpha-N-acetylglucosaminephosphotransferase 2", "tax_id": 10090, "disease": "congenital disorder of glycosylation Ij (Disease Ontology:DOID:0080562); congenital myasthenic syndrome 13 (Disease Ontology:DOID:0110676)", "pathway": " (mmu:13478); (R-MMU-446193)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10536042;1323278;21750661;30084848;31219806;8043075", "class_list": "glycogene;glycosyltransferase", "function": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transferring GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q921W5", "ec_number_list": "2.7.8.15", "go_molecular_function": "GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity;GO:0046872 metal ion binding;GO:0016757 glycosyltransferase activity;GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 15150, "hit_score": 0.7, "record_id": "P42867-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56476-1", "uniprot_id": "GBRR2_MOUSE", "mass": 54231.0, "length": 465, "protein_name": "Gamma-aminobutyric acid receptor subunit rho-2", "gene_name": "Gabrr2", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit rho-2 isoform 1 precursor", "refseq_ac": "NP_032102", "gene_names_uniprotkb": "Gabrr2", "gene_names_refseq": "Gabrr2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit rho-2; GABA(A) receptor subunit rho-2; GABA(C) receptor; GABAAR subunit rho-2", "protein_names_refseq": "GABA(A) receptor subunit rho-2; GABA(C) receptor; GABAAR subunit rho-2; gamma-aminobutyric acid (GABA) C receptor, subunit rho 2; gamma-aminobutyric acid (GABA-A) receptor, subunit rho 2; gamma-aminobutyric acid receptor rho2 subunit; gamma-aminobutyric acid receptor subunit rho-2 isoform 1 precursor; gamma-aminobutyric acid receptor subunit rho-2", "tax_id": 10090, "disease": "autistic disorder (Disease Ontology:DOID:12849); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:14409); (R-MMU-977443)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16945976;21750661;25422464;31219806;32439345", "class_list": "", "function": "Mice lacking spinal alpha2GABAA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype., [RefSeq, PubMed]; Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Rho-2 GABAARs may contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (PubMed:25422464). Rho-2 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (PubMed:16945976). Rho-2 GABAARs expressed in retina may play a role in retinal neurotransmission (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PEP0", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0097708 intracellular vesicle;GO:0030424 axon;GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007601 visual perception;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P56476-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLR9-1", "uniprot_id": "HIG1A_MOUSE", "mass": 10425.0, "length": 95, "protein_name": "HIG1 domain family member 1A, mitochondrial", "gene_name": "Higd1a", "organism": "Mouse", "refseq_name": "HIG1 domain family member 1A, mitochondrial", "refseq_ac": "NP_062788", "gene_names_uniprotkb": "Higd1a; Hig1", "gene_names_refseq": "2210020B17Rik; 7420700H20Rik; HIMP1; Hig1; Higd1a", "protein_names_uniprotkb": "HIG1 domain family member 1A, mitochondrial; Hypoxia-inducible gene 1 protein", "protein_names_refseq": "HIG1 domain family member 1A, mitochondrial; hypoxia induced gene 1; hypoxia-inducible gene 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56295); (R-MMU-9864848)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16815968;21750661;25605945;31089410;34428180;35750235;36288343;37185850;37393616;39927985", "class_list": "", "function": "HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway., [RefSeq, PubMed]; Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice., [RefSeq, PubMed]; Higd1a plays positive roles in protecting cells from oxidative stress, and reactive oxygen species could induce Higd1a expression by upregulating PGC-1a and HIF-1a expressions. Publication Status: Online-Only, [RefSeq, PubMed]; Important role in stress protective programs in mitochondria., [RefSeq, PubMed]; Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-kappaB-NR2F1 nexus., [RefSeq, PubMed]; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0071456 cellular response to hypoxia;GO:0042149 cellular response to glucose starvation;GO:0071902 positive regulation of protein serine/threonine kinase activity;GO:0090201 negative regulation of release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JLR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5PRF0-1", "uniprot_id": "HTR5A_MOUSE", "mass": 219893.0, "length": 2038, "protein_name": "HEAT repeat-containing protein 5A", "gene_name": "Heatr5a", "organism": "Mouse", "refseq_name": "HEAT repeat-containing protein 5A", "refseq_ac": "NP_796145", "gene_names_uniprotkb": "Heatr5a; Kiaa1316", "gene_names_refseq": "C230081H03Rik; D930036F22Rik; Heatr5a; mKIAA1316", "protein_names_uniprotkb": "HEAT repeat-containing protein 5A", "protein_names_refseq": "HEAT repeat-containing protein 5A", "tax_id": 10090, "disease": "", "pathway": " (mmu:320487)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;21952136;25428506;30084848;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPI0;Q3TT84;Q3V311;Q6P4S9;Q80TF2;Q8C8F7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0008104 intracellular protein localization;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5PRF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TT15-1", "uniprot_id": "GLT17_MOUSE", "mass": 67691.0, "length": 598, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 17", "gene_name": "Galnt17", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 17 precursor", "refseq_ac": "NP_660253", "gene_names_uniprotkb": "Galnt17; Wbscr17", "gene_names_refseq": "E330012B09Rik; Galnt17; Galnt19; Gcap8; Wbscr17", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 17; 2.4.1.41; GalNAc-T-like protein 3; Polypeptide GalNAc transferase-like protein 3; Protein-UDP acetylgalactosaminyltransferase-like protein 3; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3; Williams-Beuren syndrome chromosomal region 17 protein homolog; pp-GaNTase-like protein 3", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like 3; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 3; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase; Williams-Beuren syndrome chromosome region 17 homolog; galNAc-T-like protein 3; granule cell antiserum positive 8; polypeptide GalNAc transferase-like protein 3; polypeptide N-acetylgalactosaminyltransferase 17 precursor; polypeptide N-acetylgalactosaminyltransferase-like 3; pp-GaNTase-like protein 3; protein-UDP acetylgalactosaminyltransferase-like protein 3; putative polypeptide N-acetylgalactosaminyltransferase-like protein 3; williams-Beuren syndrome chromosomal region 17 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:212996); (R-MMU-913709)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12073013;21750661;25428506;30899004;36002036", "class_list": "glycogene;glycosyltransferase", "function": "Galnt17 loss-of-function leads to developmental delay and abnormal coordination, activity, and social interactions with cerebellar vermis pathology., [RefSeq, PubMed]; May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKN7;Q8BUY1;Q8BX73;Q8BZC8;Q8K483", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 7434, "hit_score": 1.2, "record_id": "Q7TT15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CRA9-1", "uniprot_id": "FGOP2_MOUSE", "mass": 29374.0, "length": 253, "protein_name": "FGFR1 oncogene partner 2 homolog", "gene_name": "Fgfr1op2", "organism": "Mouse", "refseq_name": "FGFR1 oncogene partner 2 homolog isoform 2", "refseq_ac": "NP_001334442", "gene_names_uniprotkb": "Fgfr1op2", "gene_names_refseq": "1500031J01Rik; Fgfr1op2", "protein_names_uniprotkb": "FGFR1 oncogene partner 2 homolog", "protein_names_refseq": "FGFR1 oncogene partner 2 homolog isoform 2; FGFR1 oncogene partner 2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67529)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19959814;21183079;21750661;26589915;34428180", "class_list": "", "function": "FGFR1OP2-FGFR1 fusion in hematopoietic stem cells induced myeloid leukemia and T-cell lymphoma in a mouse model., [RefSeq, PubMed]; FGFR1OP2/wit3.0 may regulate cell motility and stimulate wound closure., [RefSeq, PubMed]; May be involved in wound healing pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEX1;Q3TW81;Q9D7R0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009611 response to wounding;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CRA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3ULJ0-1", "uniprot_id": "GPD1L_MOUSE", "mass": 38226.0, "length": 351, "protein_name": "Glycerol-3-phosphate dehydrogenase 1-like protein", "gene_name": "Gpd1l", "organism": "Mouse", "refseq_name": "glycerol-3-phosphate dehydrogenase 1-like protein", "refseq_ac": "NP_780589", "gene_names_uniprotkb": "Gpd1l; Kiaa0089", "gene_names_refseq": "2210409H23Rik; D9Ertd660e; Gpd1l", "protein_names_uniprotkb": "Glycerol-3-phosphate dehydrogenase 1-like protein; 1.1.1.8", "protein_names_refseq": "glycerol-3-phosphate dehydrogenase 1-like protein", "tax_id": 10090, "disease": "Brugada syndrome 2 (Disease Ontology:DOID:0110219)", "pathway": " (mmu:333433); (R-MMU-1483166)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "19224205;19745168;20173027;21750661;22872234;31219806;33300544;35820727;37507081;39627609", "class_list": "", "function": "Mutations of GPD1-L may downregulate Na(v)1.5 by altering the oxidized to reduced NAD(H) balance., [RefSeq, PubMed]; Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6A0D2;Q8BVZ7;Q8BWM5;Q8CFN6", "ec_number_list": "1.1.1.8", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0051287 NAD binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:2000010 positive regulation of protein localization to cell surface;GO:0005975 carbohydrate metabolic process;GO:0019674 NAD+ metabolic process;GO:0010765 positive regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3ULJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58044-1", "uniprot_id": "IDI1_MOUSE", "mass": 26289.0, "length": 227, "protein_name": "Isopentenyl-diphosphate Delta-isomerase 1", "gene_name": "Idi1", "organism": "Mouse", "refseq_name": "isopentenyl-diphosphate Delta-isomerase 1", "refseq_ac": "NP_663335", "gene_names_uniprotkb": "Idi1", "gene_names_refseq": "4832416K17Rik; IPPI1; Idi1", "protein_names_uniprotkb": "Isopentenyl-diphosphate Delta-isomerase 1; 5.3.3.2; IPP isomerase 1; IPPI1; Isopentenyl pyrophosphate isomerase 1", "protein_names_refseq": "IPP isomerase 1; isopentenyl pyrophosphate isomerase 1; isopentenyl-diphosphate Delta-isomerase 1", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:319554); (R-MMU-9969896)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;14629038;21750661;22645316;34428180;37507081", "class_list": "", "function": "Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Only one of the two isoforms (IDI1) is highly conserved, ubiquitously expressed and most likely responsible for housekeeping isomerase activity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4FJU2", "ec_number_list": "5.3.3.2", "go_molecular_function": "GO:0004452 isopentenyl-diphosphate delta-isomerase activity;GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0009240 isopentenyl diphosphate biosynthetic process;GO:0050992 dimethylallyl diphosphate biosynthetic process;GO:0035634 response to stilbenoid;GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P58044-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80SU7-1", "uniprot_id": "GVIN1_MOUSE", "mass": 280815.0, "length": 2427, "protein_name": "Interferon-induced very large GTPase 1", "gene_name": "Gvin1; Gvin2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gvin1; Gvin2", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon-induced very large GTPase 1; VLIG-1; Very large-inducible GTPase-1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042856); (mmu:74558)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12874213;20484733;21750661;25428506;25428507;25605945;30084848;30779550;31219806;31599954;32152506;34428180;35820727;36210013;37453647;37507081", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3F2;Q8BL18;Q8CBA9", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q80SU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UTA9-1", "uniprot_id": "I4E1B_MOUSE", "mass": 27985.0, "length": 244, "protein_name": "Eukaryotic translation initiation factor 4E type 1B", "gene_name": "Eif4e1b", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 4E type 1B isoform 1", "refseq_ac": "NP_001028441", "gene_names_uniprotkb": "Eif4e1b; Gm273", "gene_names_refseq": "Eif4e1b; Eif4eloo; Gm273", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E type 1B; Oocyte-specific eukaryotic translation initiation factor 4E-like", "protein_names_refseq": "eukaryotic translation initiation factor 4E type 1B isoform 1; eukaryotic translation initiation factor 4E type 1B", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:218268)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16191198;17015433;21750661;36755190;37257918;38177902", "class_list": "", "function": "EIF4E1b is a non-canonical eIF4E protecting maternal dormant mRNAs., [RefSeq, PubMed]; Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation., [RefSeq, PubMed]; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures., [UniProtKB]; Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q27ZJ1", "ec_number_list": "", "go_molecular_function": "GO:0000340 RNA 7-methylguanosine cap binding;GO:0003743 translation initiation factor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0016281 eukaryotic translation initiation factor 4F complex;GO:0005737 cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0006413 translational initiation;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UTA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FH4-1", "uniprot_id": "GALK2_MOUSE", "mass": 50503.0, "length": 458, "protein_name": "N-acetylgalactosamine kinase", "gene_name": "Galk2", "organism": "Mouse", "refseq_name": "N-acetylgalactosamine kinase isoform a", "refseq_ac": "NP_001277931", "gene_names_uniprotkb": "Galk2", "gene_names_refseq": "2810017M24Rik; Galk2; Gk2", "protein_names_uniprotkb": "N-acetylgalactosamine kinase; 2.7.1.157; GalNAc kinase; Galactokinase 2", "protein_names_refseq": "N-acetylgalactosamine kinase isoform a; N-acetylgalactosamine kinase; galNAc kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:69976)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25605945;30779550;31219806;34428180;35820727", "class_list": "glycogene", "function": "Acts on GalNAc (By similarity). Also acts as a galactokinase when galactose is present at high concentrations (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.157", "go_molecular_function": "GO:0005524 ATP binding;GO:0004335 galactokinase activity;GO:0033858 N-acetylgalactosamine kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006012 galactose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q68FH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80X73-1", "uniprot_id": "PELO_MOUSE", "mass": 43349.0, "length": 385, "protein_name": "Protein pelota homolog", "gene_name": "Pelo", "organism": "Mouse", "refseq_name": "protein pelota homolog", "refseq_ac": "NP_598819", "gene_names_uniprotkb": "Pelo", "gene_names_refseq": "Pelo", "protein_names_uniprotkb": "Protein pelota homolog", "protein_names_refseq": "pelota homolog; protein pelota homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:105083); (R-MMU-9954714)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12438745;12556505;25061210;31219806;33245852;33899734;34428180;35437307", "class_list": "", "function": "CDNA cloning, genomic structure, and chromosomal localization, [RefSeq, PubMed]; Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy., [UniProtKB, UniProtKB]; Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology. Publication Status: Online-Only, [RefSeq, PubMed]; PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer., [RefSeq, PubMed]; Pelo is required for the maintenance of genomic stability, [RefSeq, PubMed]; Perturbed differentiation of murine embryonic stem cells upon Pelota deletion due to dysregulated FOXO1/beta-catenin signaling. Erratum:[FEBS J. 2026 Feb;293(4):1252-1255. doi: 10.1111/febs.70447. PMID: 41671057], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCN0;Q6PG91;Q91UZ2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0043022 ribosome binding;GO:0060589 nucleoside-triphosphatase regulator activity;GO:0170011 stalled ribosome sensor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0022626 cytosolic ribosome;GO:1990533 Dom34-Hbs1 complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay;GO:0070651 nonfunctional rRNA decay;GO:0071025 RNA surveillance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80X73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V87-1", "uniprot_id": "FGRL1_MOUSE", "mass": 57013.0, "length": 529, "protein_name": "Fibroblast growth factor receptor-like 1", "gene_name": "Fgfrl1", "organism": "Mouse", "refseq_name": "fibroblast growth factor receptor-like 1 isoform 2 precursor", "refseq_ac": "NP_001157731", "gene_names_uniprotkb": "Fgfrl1; Fgfr5", "gene_names_refseq": "FGFR5beta; FGFR5gamma; FGFR5; Fgfrl1", "protein_names_uniprotkb": "Fibroblast growth factor receptor-like 1; FGF receptor-like protein 1; FGFR-5; Fibroblast growth factor receptor 5", "protein_names_refseq": "FGF receptor-like protein 1; fibroblast growth factor receptor 5; fibroblast growth factor receptor-like 1 isoform 2 precursor", "tax_id": 10090, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460)", "pathway": " (mmu:116701); (R-MMU-5658623)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11418238;11566361;12813049;16525717;21750661;30217817;31923383;33019532;34428180", "class_list": "", "function": "Dissecting the Interaction of FGF8 with Receptor FGFRL1. Publication Status: Online-Only, [RefSeq, PubMed]; FGFR5 as a co-receptor that is up-regulated by inflammation and promotes FGFR1-induced survival., [RefSeq, PubMed]; FGFRL1 expression is very low in mouse embryos of day 6 but steadily increases until birth., [RefSeq, PubMed]; Functional domains of the FgfrL1 receptor., [RefSeq, PubMed]; Has a negative effect on cell proliferation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q920C2;Q920C3", "ec_number_list": "", "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0017134 fibroblast growth factor binding;GO:0001571 non-tyrosine kinase fibroblast growth factor receptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030133 transport vesicle;GO:0044291 cell-cell contact zone", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0098609 cell-cell adhesion;GO:0001501 skeletal system development;GO:0060412 ventricular septum morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91V87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERL7-1", "uniprot_id": "GMFG_MOUSE", "mass": 16748.0, "length": 142, "protein_name": "Glia maturation factor gamma", "gene_name": "Gmfg", "organism": "Mouse", "refseq_name": "glia maturation factor gamma isoform a", "refseq_ac": "NP_001034281", "gene_names_uniprotkb": "Gmfg", "gene_names_refseq": "0610039G16Rik; 2310057N07Rik; Gmfg", "protein_names_uniprotkb": "Glia maturation factor gamma; GMF-gamma", "protein_names_refseq": "GMF-gamma; glia maturation factor gamma isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:63986); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16873721;19768801;21750661;23727094;23893131;28315936;29339159;30971398;31219806;34428180;34673932", "class_list": "", "function": "Findings suggest that GMFG is an important regulator in cellular iron metabolism and macrophage phenotype and could be a novel therapeutic target for modulating macrophage function in immune and metabolic disorders., [RefSeq, PubMed]; GMF debranches filaments by a mechanism related to cofilin-mediated severing, but in which GMF has evolved to target molecular junctions between actin-related proteins in the Arp2/3 complex and actin subunits in the daughter filament of the branch., [RefSeq, PubMed]; GMFG is a novel factor in actin cytoskeleton reorganization and is expressed preferentially in microvascular endothelial and inflammatory cells in embryonic development., [RefSeq, PubMed]; Glia maturation factor-gamma is involved in S1P-induced marginal zone B-cell chemotaxis and optimal IgM production to type II T-independent antigen., [RefSeq, PubMed]; Gmfg has two separate binding sites on Arp2/3 complex with high (site 1) and low (site 2) affinity. X-ray crystallography revealed closely located positions of Gmfg in site 1. Molecular dynamics simulation allowed determining the binding pocket for Gmfg in site 2., [RefSeq, PubMed]; The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008083 growth factor activity;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0030864 cortical actin cytoskeleton;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071944 cell periphery", "go_biological_process": "GO:0071846 actin filament debranching;GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9ERL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TFK5-1", "uniprot_id": "GPTC4_MOUSE", "mass": 46554.0, "length": 415, "protein_name": "G patch domain-containing protein 4", "gene_name": "Gpatch4", "organism": "Mouse", "refseq_name": "G patch domain-containing protein 4", "refseq_ac": "NP_001104279", "gene_names_uniprotkb": "Gpatch4; Gpatc4", "gene_names_refseq": "2610029K21Rik; Gpatc4; Gpatch4", "protein_names_uniprotkb": "G patch domain-containing protein 4", "protein_names_refseq": "G patch domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:66614)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17242355;21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCN2;Q9CU32;Q9D3L4", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TFK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CB44-1", "uniprot_id": "GRAM4_MOUSE", "mass": 72264.0, "length": 633, "protein_name": "GRAM domain-containing protein 4", "gene_name": "Gramd4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gramd4; Dip; Kiaa0767", "gene_names_refseq": "", "protein_names_uniprotkb": "GRAM domain-containing protein 4; Death-inducing protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:223752)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;25917084", "class_list": "", "function": "Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (By similarity). Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (PubMed:25917084)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RTC1;Q6ZQ52;Q8VDL6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0034164 negative regulation of toll-like receptor 9 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CB44-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14BI2-1", "uniprot_id": "GRM2_MOUSE", "mass": 95887.0, "length": 872, "protein_name": "Metabotropic glutamate receptor 2", "gene_name": "Grm2", "organism": "Mouse", "refseq_name": "metabotropic glutamate receptor 2 precursor", "refseq_ac": "NP_001153825", "gene_names_uniprotkb": "Grm2; Gprc1b; Mglur2", "gene_names_refseq": "4930441L02Rik; Gprc1b; Grm2; mGluR2; mGluR7", "protein_names_uniprotkb": "Metabotropic glutamate receptor 2; mGluR2", "protein_names_refseq": "G protein-coupled receptor, family C, group 1, member B; metabotropic glutamate receptor 2 precursor; metabotropic glutamate receptor 2", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:108068); (R-MMU-418594); (R-MMU-420499)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;15753323;18297054;21750661;23129762;30899004;32848054;33300544;36878727;38864289;7965099;8662555", "class_list": "", "function": "Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses., [RefSeq, PubMed]; Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (By similarity). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (PubMed:7965099). Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; GRM2 Regulates Functional Integration of Adult-Born DGCs by Paradoxically Modulating MEK/ERK1/2 Pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0097110 scaffold protein binding;GO:0001641 group II metabotropic glutamate receptor activity;GO:0008066 glutamate receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0014048 regulation of glutamate secretion;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0035095 behavioral response to nicotine;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0014059 regulation of dopamine secretion", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q14BI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6F4-1", "uniprot_id": "GBRA4_MOUSE", "mass": 60878.0, "length": 552, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-4", "gene_name": "Gabra4", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-4 isoform 2 precursor", "refseq_ac": "NP_034381", "gene_names_uniprotkb": "Gabra4", "gene_names_refseq": "Gabra-4; Gabra4", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor subunit alpha-4; GABAAR subunit alpha-4", "protein_names_refseq": "GABA(A) receptor subunit alpha-4; GABAAR subunit alpha-4; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4; gamma-aminobutyric acid receptor subunit alpha-4 isoform 2 precursor; gamma-aminobutyric acid receptor subunit alpha-4", "tax_id": 10090, "disease": "autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (mmu:14397); (R-MMU-977443)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17005728;21750661;30899004;33300544;34203471", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:17005728). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). Alpha-4/GABRA4 subunit often assembles with delta or gamma-2 subunits, in combination with beta subunits (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:17005728). GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons (PubMed:17005728). Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity (PubMed:17005728). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007417 central nervous system development;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9D6F4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810D6-1", "uniprot_id": "GRWD1_MOUSE", "mass": 49224.0, "length": 446, "protein_name": "Glutamate-rich WD repeat-containing protein 1", "gene_name": "Grwd1", "organism": "Mouse", "refseq_name": "glutamate-rich WD repeat-containing protein 1 isoform 1", "refseq_ac": "NP_700468", "gene_names_uniprotkb": "Grwd1; A301", "gene_names_refseq": "A301; Grwd1; Grwd; Wdr28", "protein_names_uniprotkb": "Glutamate-rich WD repeat-containing protein 1; Protein A301", "protein_names_refseq": "glutamate rich WD repeat protein GRWD; glutamate-rich WD repeat-containing protein 1 isoform 1; glutamate-rich WD repeat-containing protein 1", "tax_id": 10090, "disease": "congenital diarrhea (Disease Ontology:DOID:0060774)", "pathway": " (mmu:101612)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25153642;38172445", "class_list": "", "function": "GRWD1 Over-Expression Promotes Gastric Cancer Progression by Activating Notch Signaling Pathway via Up-Regulation of ADAM17., [RefSeq, PubMed]; Histone binding protein that regulates chromatin dynamics and loading of minichromosome maintenance (MCM) complex at replication origins, possibly by promoting chromatin openness. Plays a role in ribosomal biogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3UVT6;Q922H3", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0006260 DNA replication;GO:0042254 ribosome biogenesis;GO:0006334 nucleosome assembly;GO:0006337 nucleosome disassembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q810D6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJ61-1", "uniprot_id": "GLT16_MOUSE", "mass": 62875.0, "length": 558, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 16", "gene_name": "Galnt16", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 16", "refseq_ac": "NP_001074890", "gene_names_uniprotkb": "Galnt16; Galntl1", "gene_names_refseq": "5730405L21Rik; Galnt16; Galntl1; galNAc-T16; mpp-GalNAc-T16", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 16; 2.4.1.41; GalNAc-T-like protein 1; GalNAc-T16; Polypeptide GalNAc transferase 16; Polypeptide GalNAc transferase-like protein 1; Polypeptide N-acetylgalactosaminyltransferase-like protein 1; Protein-UDP acetylgalactosaminyltransferase-like protein 1; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1; pp-GaNTase-like protein 1", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1; galNAc-T-like protein 1; polypeptide GalNAc transferase 16; polypeptide GalNAc transferase-like protein 1; polypeptide N-acetylgalactosaminyltransferase 16; pp-GaNTase-like protein 1; protein-UDP acetylgalactosaminyltransferase-like protein 1; putative polypeptide N-acetylgalactosaminyltransferase-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:108760); (R-MMU-913709)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15018805;21750661;25428506", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 24, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60GT0", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 0.4, "record_id": "Q9JJ61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DC33-1", "uniprot_id": "HM20A_MOUSE", "mass": 39917.0, "length": 346, "protein_name": "High mobility group protein 20A", "gene_name": "Hmg20a", "organism": "Mouse", "refseq_name": "high mobility group protein 20A", "refseq_ac": "NP_080088", "gene_names_uniprotkb": "Hmg20a; Ibraf", "gene_names_refseq": "1200004E06Rik; 5730490E10Rik; Hmg20a; Hmgxb1; Ibraf", "protein_names_uniprotkb": "High mobility group protein 20A; HMG box-containing protein 20A; HMG domain-containing protein HMGX1; Inhibitor of BRAF35; iBRAF", "protein_names_refseq": "HMG box-containing protein 20A; HMG domain-containing protein HMGX1; high mobility group protein 20A; inhibitor of BRAF35", "tax_id": 10090, "disease": "", "pathway": " (mmu:66867)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10773667;16227968;20530487;21183079;21750661", "class_list": "", "function": "Ectopic expression of iBRAF induces neuronal differentiation through recruitment of MLL, resulting in increased histone H3K4 trimethylation and activation of neuronal-specific genes., [RefSeq, PubMed]; Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3LSF9;Q6NV87;Q8BSK1;Q8C3C1;Q8CAA0;Q9CYG2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045665 negative regulation of neuron differentiation;GO:0006325 chromatin organization;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DC33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CF93-1", "uniprot_id": "GLT13_MOUSE", "mass": 63983.0, "length": 556, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 13", "gene_name": "Galnt13", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 13", "refseq_ac": "NP_766618", "gene_names_uniprotkb": "Galnt13", "gene_names_refseq": "A230002A12; A230020F20; Galnt13", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 13; 2.4.1.41; GalNAc-T13; Polypeptide GalNAc transferase 13; Protein-UDP acetylgalactosaminyltransferase 13; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13; pp-GaNTase 13", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13; galNAc-T13; polypeptide GalNAc transferase 13; polypeptide N-acetylgalactosaminyltransferase 13; pp-GaNTase 13; pp-GalNAc-T13; protein-UDP acetylgalactosaminyltransferase 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:271786); (R-MMU-913709)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12407114;12651884;21750661;22306014;27629416;33300544;8618846", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor (PubMed:12407114, PubMed:27629416, PubMed:8618846). Generates GalNAc-O-Ser/Thr structure also known as Tn antigen, which itself is immunogenic but also serves as a precursor for the synthesis of different mucin-type O-glycan core structures (PubMed:12407114). Contributes to the synthesis of O-linked glycans on mucins and proteoglycans of the central nervous system (PubMed:12407114, PubMed:27629416). Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC. Transfers GalNAc to three consecutive serine/threonine residues on SDC3 forming a triplet-Tn epitope expressed in Purkinje cells of the developing brain (By similarity). May promote neurogenesis through glycosylation and stabilization of PDPN (PubMed:27629416)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Cloning and characterization of pp-GalNAc-T13; expressed in all neuroblastoma cells examined and primary cultured neurons but not in glioblastoma cells and primary cultured astrocytes, [RefSeq, PubMed]; These data suggested that high expression of pp-GalNAc-T13 gene generated trimeric Tn antigen on Syndecan-1, leading to the enhanced metastasis., [RefSeq, PubMed]; This study suggests that ppGalNAc-T13 contributes to neuronal differentiation through glycosylating and stabilizing PDPN, which provides insights into the regulatory roles of O-glycosylation in mammalian neural development., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLE4;Q8BYT3", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 1.3, "record_id": "Q8CF93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14429-1", "uniprot_id": "HA17_MOUSE", "mass": 37924.0, "length": 334, "protein_name": "H-2 class I histocompatibility antigen, Q7 alpha chain", "gene_name": "H2-Q7", "organism": "Mouse", "refseq_name": "H-2 class I histocompatibility antigen, Q7 alpha chain isoform 1 precursor", "refseq_ac": "NP_034524", "gene_names_uniprotkb": "H2-Q7; H2-Q4", "gene_names_refseq": "H-2Q7; H2-Q7; Ped; Q9; Qa-2; Qa-7; Qa7", "protein_names_uniprotkb": "H-2 class I histocompatibility antigen, Q7 alpha chain; QA-2 antigen", "protein_names_refseq": "H-2 class I histocompatibility antigen, Q7 alpha chain isoform 1 precursor; H-2 class I histocompatibility antigen, Q7 alpha chain; QA-2 antigen; class Ib MHC antigen Qa-2", "tax_id": 10090, "disease": "Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); colitis (Disease Ontology:DOID:0060180); Cytomegalovirus retinitis (Disease Ontology:DOID:0080160); COVID-19 (Disease Ontology:DOID:0080600); ankylosing spondylitis 1 (Disease Ontology:DOID:0080603); erythema nodosum (Disease Ontology:DOID:0080750); occupational asthma (Disease Ontology:DOID:0080820); graft-versus-host disease (Disease Ontology:DOID:0081267); birdshot chorioretinopathy (Disease Ontology:DOID:0111079); psoriasis 1 (Disease Ontology:DOID:0111286); sensorineural hearing loss (Disease Ontology:DOID:10003); pre-eclampsia (Disease Ontology:DOID:10591); spondyloarthropathy (Disease Ontology:DOID:1123); trachoma (Disease Ontology:DOID:11265); sarcoidosis (Disease Ontology:DOID:11335); retinal vasculitis (Disease Ontology:DOID:11563); otosclerosis (Disease Ontology:DOID:12185); Graves' disease (Disease Ontology:DOID:12361); vulva cancer (Disease Ontology:DOID:1245); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); thromboangiitis obliterans (Disease Ontology:DOID:12918); retinopathy of prematurity (Disease Ontology:DOID:13025); Moyamoya disease (Disease Ontology:DOID:13099); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); anterior uveitis (Disease Ontology:DOID:1407); cystic fibrosis (Disease Ontology:DOID:1485); Melkersson-Rosenthal syndrome (Disease Ontology:DOID:1761); hepatitis C (Disease Ontology:DOID:1883); Takayasu's arteritis (Disease Ontology:DOID:2508); synovitis (Disease Ontology:DOID:2703); dermatitis (Disease Ontology:DOID:2723); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); cerebral infarction (Disease Ontology:DOID:3526); acute retinal necrosis syndrome (Disease Ontology:DOID:3611); thrombophlebitis (Disease Ontology:DOID:3875); tuberculosis (Disease Ontology:DOID:399); scleroderma (Disease Ontology:DOID:419); cervical cancer (Disease Ontology:DOID:4362); allergic rhinitis (Disease Ontology:DOID:4481); central nervous system vasculitis (Disease Ontology:DOID:525); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); uveal melanoma (Disease Ontology:DOID:6039); reactive arthritis (Disease Ontology:DOID:6196); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); ankylosing spondylitis (Disease Ontology:DOID:7147); diabetic retinopathy (Disease Ontology:DOID:8947); allergic asthma (Disease Ontology:DOID:9415); Meniere's disease (Disease Ontology:DOID:9849); alopecia (Disease Ontology:DOID:987); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (mmu:15018); (R-MMU-1236974); (R-MMU-1236977); (R-MMU-198933); (R-MMU-6798695); (R-MMU-983170)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;2249652;2584927;3004940;31219806;34428180;3502706;36210013;6895187", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 52, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0046978 TAP1 binding;GO:0046979 TAP2 binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0032398 MHC class Ib protein complex;GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P14429-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U6U5-1", "uniprot_id": "GTPB6_MOUSE", "mass": 56475.0, "length": 514, "protein_name": "Putative GTP-binding protein 6", "gene_name": "Gtpbp6", "organism": "Mouse", "refseq_name": "putative GTP-binding protein 6", "refseq_ac": "NP_660129", "gene_names_uniprotkb": "Gtpbp6", "gene_names_refseq": "Gtpbp6; Pgbpll; pgpl", "protein_names_uniprotkb": "Putative GTP-binding protein 6", "protein_names_refseq": "pseudoautosomal GTP binding protein-like, like; putative GTP-binding protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:107999)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TX13;Q3UMM2", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0043022 ribosome binding;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1902775 mitochondrial large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3U6U5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61016-1", "uniprot_id": "GBG7_MOUSE", "mass": 7480.0, "length": 68, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7", "gene_name": "Gng7", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7", "refseq_ac": "NP_001033744", "gene_names_uniprotkb": "Gng7; Gngt7", "gene_names_refseq": "Gng7; Hg3b", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7", "protein_names_refseq": "guanine nucleotide binding protein (G protein), gamma 7 subunit; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7; heterotrimeric guanine nucleotide-binding protein 3b", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14708); (R-MMU-1296041); (R-MMU-202040); (R-MMU-381676); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 28, "publication_count": 5, "publication_id_list": "12488442;21750661;31759625;34544837;8858601", "class_list": "", "function": "Ggamma7-specific prothymosin alpha deletion causes stress- and age-dependent motor dysfunction and anxiety., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Selective Manipulation of G-Protein gamma7 Subunit in Mice Provides New Insights into Striatal Control of Motor Behavior., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZP6", "ec_number_list": "", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0045202 synapse;GO:0030672 synaptic vesicle membrane;GO:0005834 heterotrimeric G-protein complex;GO:0098685 Schaffer collateral - CA1 synapse;GO:0098688 parallel fiber to Purkinje cell synapse", "go_biological_process": "GO:0045761 regulation of adenylate cyclase activity;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007626 locomotory behavior;GO:0001662 behavioral fear response;GO:0007168 receptor guanylyl cyclase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61016-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB32-1", "uniprot_id": "HAGHL_MOUSE", "mass": 31490.0, "length": 283, "protein_name": "Hydroxyacylglutathione hydrolase-like protein", "gene_name": "Haghl", "organism": "Mouse", "refseq_name": "hydroxyacylglutathione hydrolase-like protein isoform a", "refseq_ac": "NP_001258362", "gene_names_uniprotkb": "Haghl", "gene_names_refseq": "1500017E18Rik; 2810014I23Rik; C330022E15Rik; Haghl", "protein_names_uniprotkb": "Hydroxyacylglutathione hydrolase-like protein; 3.1.2.-", "protein_names_refseq": "hydroxyacylglutathione hydrolase-like protein isoform a; hydroxyacylglutathione hydrolase-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68977)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25605945;34428180", "class_list": "", "function": "Hydrolase acting on ester bonds., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8C4", "ec_number_list": "", "go_molecular_function": "GO:0004416 hydroxyacylglutathione hydrolase activity;GO:0046872 metal ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DB32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEM1-1", "uniprot_id": "GOLI_MOUSE", "mass": 46376.0, "length": 419, "protein_name": "E3 ubiquitin-protein ligase RNF130", "gene_name": "Rnf130", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF130 isoform 2 precursor", "refseq_ac": "NP_001277678", "gene_names_uniprotkb": "Rnf130; G1rp", "gene_names_refseq": "2510042A13Rik; G1RZFP; G1rp; GOLIATH; GP; Rnf130", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF130; 2.3.2.27; G1-related zinc finger protein; Goliath homolog; RING finger protein 130; RING-type E3 ubiquitin transferase RNF130", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF130 isoform 2 precursor; E3 ubiquitin-protein ligase RNF130; RING-type E3 ubiquitin transferase RNF130; g1-related zinc finger protein; goliath homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:59044); (R-MMU-983168)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10806348;21750661;30899004;31219806;36862324;36893517;40885482", "class_list": "", "function": "Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells., [UniProtKB, PubMed]; Acts as an E3 ubiquitin-protein ligase. May have a role during the programmed cell death of hematopoietic cells., [UniProtKB, UniProtKB, UniProtKB]; Goliath induces inflammation in obese mice by linking fatty acid beta-oxidation to glycolysis., [RefSeq, PubMed]; RNF130 protects against pulmonary fibrosis through suppressing aerobic glycolysis by mediating c-myc ubiquitination., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q80VL7;Q9QZQ6", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8VEM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ES18-1", "uniprot_id": "FOXJ2_MOUSE", "mass": 61570.0, "length": 565, "protein_name": "Forkhead box protein J2", "gene_name": "Foxj2", "organism": "Mouse", "refseq_name": "forkhead box protein J2", "refseq_ac": "NP_068699", "gene_names_uniprotkb": "Foxj2; Fhx", "gene_names_refseq": "Fhx; Foxj2", "protein_names_uniprotkb": "Forkhead box protein J2; Fork head homologous X", "protein_names_refseq": "fork head homologous X; forkhead box protein J2", "tax_id": 10090, "disease": "", "pathway": " (mmu:60611)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11025217;16376864;18726704;21750661;27316861;30084848;34428180;35908066", "class_list": "", "function": "Biological effects of Foxj2 overexpression during development are reported., [RefSeq, PubMed]; FOXJ2 appears to promote meiotic progression in male mice by a mechanism that needs further investigation., [RefSeq, PubMed]; Germline FOXJ2 overexpression causes male infertility via aberrant autophagy activation by LAMP2A upregulation. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional activator. Able to bind to two different type of DNA binding sites (By similarity). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (PubMed:11025217, PubMed:15489334)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0110059 negative regulation of blood vessel endothelial cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ES18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JL27-1", "uniprot_id": "FUT2_MOUSE", "mass": 39243.0, "length": 347, "protein_name": "Galactoside alpha-(1,2)-fucosyltransferase 2", "gene_name": "Fut2", "organism": "Mouse", "refseq_name": "galactoside alpha-(1,2)-fucosyltransferase 2", "refseq_ac": "NP_001258922", "gene_names_uniprotkb": "Fut2; Sec2", "gene_names_refseq": "Fut2; MFUT-II", "protein_names_uniprotkb": "Galactoside alpha-(1,2)-fucosyltransferase 2; 2.4.1.344; 2.4.1.69; Alpha(1,2)FT 2; Fucosyltransferase 2; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase; MFUT-II; Secretory blood group protein 2; Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2; Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2", "protein_names_refseq": "GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase; alpha(1,2)FT 2; galactoside 2-alpha-L-fucosyltransferase 2; galactoside alpha-(1,2)-fucosyltransferase 2; secretory blood group protein 2; type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2; type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2", "tax_id": 10090, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731)", "pathway": " (mmu:14344); (R-MMU-9033807); (R-MMU-9037629); (R-MMU-9840309)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "11018479;11323419;11368156;11713270;14967068;19706747;21750661;24284406;27161092;35820727;36739428;36973740;38897123", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:11018479, PubMed:11323419, PubMed:11368156, PubMed:14967068, PubMed:19706747, PubMed:27161092). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (PubMed:11713270, PubMed:14967068). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:19706747, PubMed:27161092). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:11323419)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation. Publication Status: Online-Only, [RefSeq, PubMed]; Fut2 deficiency aggravates chronic colitis through 2-oxindole-AHR mediated cGAS-STING pathway., [RefSeq, PubMed]; Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 37, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O70504", "ec_number_list": "2.4.1.344;2.4.1.69;2.4.1.-", "go_molecular_function": "GO:0008417 fucosyltransferase activity;GO:0031127 alpha-(1,2)-fucosyltransferase activity;GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0009312 oligosaccharide biosynthetic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 1540, "hit_score": 1.4, "record_id": "Q9JL27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01721-1", "uniprot_id": "GAS1_MOUSE", "mass": 35694.0, "length": 343, "protein_name": "Growth arrest-specific protein 1", "gene_name": "Gas1", "organism": "Mouse", "refseq_name": "growth arrest-specific protein 1", "refseq_ac": "NP_032112", "gene_names_uniprotkb": "Gas1; Gas-1", "gene_names_refseq": "Gas-1; Gas1", "protein_names_uniprotkb": "Growth arrest-specific protein 1; GAS-1", "protein_names_refseq": "growth arrest-specific protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14451); (R-MMU-5632681); (R-MMU-5635838)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10996315;11456441;11572986;12399319;1505026;17504940;21664576;21750661;33038332;34799735", "class_list": "", "function": "Coreceptor required for sonic hedgehog (SHH) handoff to its receptor: binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) downstream of the CDON-BOC heterodimer and directly transfers ShhN to its patched receptor (PTCH1 or PTCH2), followed by activation of the smoothened signaling pathway (PubMed:17504940, PubMed:21664576, PubMed:33038332). Specifically recognizes and binds palmitate and cholesterol moieties in dually lipid-modified ShhN (PubMed:33038332). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (PubMed:34799735). Acts as a growth arrest protein involved in growth suppression by blocking entry to S phase (PubMed:1505026)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008142 oxysterol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0060628 regulation of ER to Golgi vesicle-mediated transport;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0050680 negative regulation of epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q01721-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESP5-1", "uniprot_id": "FEZF2_MOUSE", "mass": 48931.0, "length": 455, "protein_name": "Fez family zinc finger protein 2", "gene_name": "Fezf2", "organism": "Mouse", "refseq_name": "fez family zinc finger protein 2", "refseq_ac": "NP_536681", "gene_names_uniprotkb": "Fezf2; Fezl; Fez; Zfp312", "gene_names_refseq": "Fezf2; Fezl; Fez; Zfp312", "protein_names_uniprotkb": "Fez family zinc finger protein 2; Forebrain embryonic zinc finger-like protein 2; Zinc finger protein 312; Zinc finger protein Fez-like", "protein_names_refseq": "fez family zinc finger protein 2; forebrain embryonic zinc finger-like protein 2; forebrain embryonic zinc finger; zinc finger protein 312", "tax_id": 10090, "disease": "", "pathway": " (mmu:54713)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11025224;15188439;16157277;16314561;16540508;16971467;21750661", "class_list": "", "function": "Fezl functions in the formation of subplate neurons and thalamocortical axons., [RefSeq, PubMed]; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9D298", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1902667 regulation of axon guidance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007626 locomotory behavior;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ESP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61060-1", "uniprot_id": "FOXD3_MOUSE", "mass": 46345.0, "length": 465, "protein_name": "Forkhead box protein D3", "gene_name": "Foxd3", "organism": "Mouse", "refseq_name": "forkhead box protein D3", "refseq_ac": "NP_034555", "gene_names_uniprotkb": "Foxd3; Hfh2", "gene_names_refseq": "CWH3; Foxd3; Genesis; Hfh2", "protein_names_uniprotkb": "Forkhead box protein D3; HFH-2; HNF3/FH transcription factor genesis; Hepatocyte nuclear factor 3 forkhead homolog 2", "protein_names_refseq": "HFH-2; HNF-3/forkhead homolog 2; HNF3/FH transcription factor genesis; forkhead box protein D3; hepatocyte nuclear factor 3 forkhead homolog 2", "tax_id": 10090, "disease": "vitiligo (Disease Ontology:DOID:12306); glaucoma (Disease Ontology:DOID:1686)", "pathway": " (mmu:15221)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11684651;12381664;21750661;25428506;36852467;8798505;9767163", "class_list": "", "function": "Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor (PubMed:12381664, PubMed:8798505). Also acts as a transcriptional activator (PubMed:12381664, PubMed:8798505). Negatively regulates transcription of transcriptional repressor Rhit/Zfp13 (By similarity). Promotes development of neural crest cells from neural tube progenitors (PubMed:12381664, PubMed:8798505). Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation (PubMed:12381664, PubMed:8798505). Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (PubMed:12381664, PubMed:8798505)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q61060-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYL5-1", "uniprot_id": "GAPR1_MOUSE", "mass": 17090.0, "length": 154, "protein_name": "Golgi-associated plant pathogenesis-related protein 1", "gene_name": "Glipr2", "organism": "Mouse", "refseq_name": "Golgi-associated plant pathogenesis-related protein 1", "refseq_ac": "NP_081726", "gene_names_uniprotkb": "Glipr2; Gapr1", "gene_names_refseq": "5730414A08Rik; GAPR-1; Glipr2", "protein_names_uniprotkb": "Golgi-associated plant pathogenesis-related protein 1; GAPR-1; GliPR 2; Glioma pathogenesis-related protein 2; Golgi-associated PR-1 protein", "protein_names_refseq": "Golgi-associated plant pathogenesis-related protein 1; gliPR 2; glioma pathogenesis-related protein 2; golgi-associated PR-1 protein", "tax_id": 10090, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (mmu:384009)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17055234;21750661;28733476;33222586;34428180;37828378", "class_list": "", "function": "GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex., [RefSeq, PubMed]; Increased GLIPR-2 expression in kidney contributes to development of fibrosis by increasing the pool of activated fibroblasts, possibly through the induction of epithelial to mesenchymal transition., [RefSeq, PubMed]; MiR-30e is downregulated in diabetic nephropathy, and the overexpression of miR-30e can inhibit GLIPR-2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ42;Q8BTK4", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0010718 positive regulation of epithelial to mesenchymal transition;GO:0010634 positive regulation of epithelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CYL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESL9-1", "uniprot_id": "FGF20_MOUSE", "mass": 23614.0, "length": 211, "protein_name": "Fibroblast growth factor 20", "gene_name": "Fgf20", "organism": "Mouse", "refseq_name": "fibroblast growth factor 20", "refseq_ac": "NP_085113", "gene_names_uniprotkb": "Fgf20", "gene_names_refseq": "Fgf20; Fgf4a", "protein_names_uniprotkb": "Fibroblast growth factor 20; FGF-20", "protein_names_refseq": "fibroblast growth factor 20; fibroblast growth factor 4a", "tax_id": 10090, "disease": "renal agenesis (Disease Ontology:DOID:14766)", "pathway": " (mmu:80857); (R-MMU-109704); (R-MMU-1257604); (R-MMU-190322); (R-MMU-190371); (R-MMU-190372); (R-MMU-190373); (R-MMU-190375); (R-MMU-5654219); (R-MMU-5654221); (R-MMU-5654227); (R-MMU-5654228); (R-MMU-5654687); (R-MMU-5654688); (R-MMU-5654689); (R-MMU-5654693); (R-MMU-5654695); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654710); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5654720); (R-MMU-5654726); (R-MMU-5654727); (R-MMU-5654732); (R-MMU-5654733); (R-MMU-5673001); (R-MMU-6811558)", "pathway_count": 31, "publication_count": 5, "publication_id_list": "11900978;18524904;21750661;39129916;39217880", "class_list": "glycogene", "function": "Expression of FGF20 in calvarial and limb development, [RefSeq, PubMed]; FGF20 modulates gut microbiota to mitigate dextran sodium sulfate-induced ulcerative colitis in mouse models., [RefSeq, PubMed]; Fgf20 is expressed at the right time and place to mediate sensory cell specification and is the likely activator/ligand of fibroblast growth factor (FGF) receptor 1 during cochlear development., [RefSeq, PubMed]; Neurotrophic factor that regulates central nervous development and function., [UniProtKB]; Skeletal dysmorphology and mineralization defects in Fgf20 KO mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7A8", "ec_number_list": "", "go_molecular_function": "GO:0090722 receptor-receptor interaction;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0043410 positive regulation of MAPK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ESL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2I3-1", "uniprot_id": "FMO2_MOUSE", "mass": 60974.0, "length": 535, "protein_name": "Dimethylaniline monooxygenase [N-oxide-forming] 2", "gene_name": "Fmo2", "organism": "Mouse", "refseq_name": "dimethylaniline monooxygenase [N-oxide-forming] 2", "refseq_ac": "NP_061369", "gene_names_uniprotkb": "Fmo2", "gene_names_refseq": "2310008D08Rik; 2310042I22Rik; Fmo2", "protein_names_uniprotkb": "Dimethylaniline monooxygenase [N-oxide-forming] 2; 1.14.13.-; Dimethylaniline oxidase 2; FMO 2; Pulmonary flavin-containing monooxygenase 2", "protein_names_refseq": "FMO 2; dimethylaniline monooxygenase [N-oxide-forming] 2; dimethylaniline oxidase 2; pulmonary flavin-containing monooxygenase 2", "tax_id": 10090, "disease": "chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411)", "pathway": " (mmu:55990); (R-MMU-217271)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11835629;18930751;21750661;37507081;37800598", "class_list": "", "function": "Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation (PubMed:18930751). Catalyzes the S-oxygenation of the prodrug ethionamide (ETA) to the S-oxide (ETASO), the first step in its bioactivation following by the second oxygenation to the sulfinic acid but to a lesser extend (PubMed:18930751)., [UniProtKB, PubMed]; Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI-CKD transformation., [RefSeq, PubMed]; Sequencing, expression, and characterization of cDNA, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZF7", "ec_number_list": "1.14.13.-", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0050661 NADP binding;GO:0004497 monooxygenase activity;GO:0004499 N,N-dimethylaniline monooxygenase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0046322 negative regulation of fatty acid oxidation;GO:0097009 energy homeostasis;GO:0006805 xenobiotic metabolic process;GO:0009404 toxin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K2I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TYB5-1", "uniprot_id": "FEZ2_MOUSE", "mass": 39101.0, "length": 348, "protein_name": "Fasciculation and elongation protein zeta-2", "gene_name": "Fez2", "organism": "Mouse", "refseq_name": "fasciculation and elongation protein zeta-2 isoform 2", "refseq_ac": "NP_955519", "gene_names_uniprotkb": "Fez2", "gene_names_refseq": "9030616F16; D17Ertd315e; Fez2", "protein_names_uniprotkb": "Fasciculation and elongation protein zeta-2; Zygin II; Zygin-2", "protein_names_refseq": "fasciculation and elongation protein zeta-2 isoform 2; zygin 2; zygin II", "tax_id": 10090, "disease": "Jacobsen Syndrome (Disease Ontology:DOID:0111723)", "pathway": " (mmu:225020)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14697253;21750661;32782141;34428180", "class_list": "", "function": "FEZ2 plays an important role in the morphological changes of various cells by associating with PKCzeta in a tissue-non-specific manner, [RefSeq, PubMed]; Involved in axonal outgrowth and fasciculation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6TYB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZW2-1", "uniprot_id": "FEV_MOUSE", "mass": 24991.0, "length": 237, "protein_name": "Protein FEV", "gene_name": "Fev", "organism": "Mouse", "refseq_name": "protein FEV", "refseq_ac": "NP_694751", "gene_names_uniprotkb": "Fev; Pet1", "gene_names_refseq": "Fev; Pet-1; Pet1; Pex1; mPet-1", "protein_names_uniprotkb": "Protein FEV; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; Pet-1; mPet-1", "protein_names_refseq": "ETS-domain transcription factor Pet-1; FEV (ETS oncogene family); FEV (fifth Ewing variant); PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; pheochromocytoma 12 ETS (E26 transformation-specific); plasmacytoma expressed transcript 1; protein FEV", "tax_id": 10090, "disease": "", "pathway": " (mmu:260298)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11875656;12546819;14602809;17656160;21750661", "class_list": "", "function": "Expressed in central serotonergic (5-hydroxytryptaminergic) neurons located in the mes-/metencephalic raphe nuclei from E11 on until adulthood, [RefSeq, PubMed]; Functions as a transcriptional regulator. May function as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth., [UniProtKB, PubMed, PubMed, PubMed]; Pet-1 is a critical determinant of 5-HT neuron identity and Pet-1-dependent program is involved in serotonergic modulation of behavior, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8QZW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFR2-1", "uniprot_id": "FSTL5_MOUSE", "mass": 95816.0, "length": 847, "protein_name": "Follistatin-related protein 5", "gene_name": "Fstl5", "organism": "Mouse", "refseq_name": "follistatin-related protein 5 precursor", "refseq_ac": "NP_001240648", "gene_names_uniprotkb": "Fstl5; Kiaa1263", "gene_names_refseq": "9130207J01Rik; Fstl5", "protein_names_uniprotkb": "Follistatin-related protein 5; Follistatin-like protein 5; m-D/Bsp120I 1-2", "protein_names_refseq": "follistatin-like protein 5; follistatin-related protein 5 precursor; follistatin-related protein 5; m-D/Bsp120I 1-2; ollistatin-like 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:213262)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;24588779", "class_list": "", "function": "Restricted expression in the olfactory system suggests a possible role for Fstl5 in maintaining odor perception, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80TG3;Q8C4T3", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0030154 cell differentiation;GO:0030510 regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BFR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56475-1", "uniprot_id": "GBRR1_MOUSE", "mass": 55488.0, "length": 480, "protein_name": "Gamma-aminobutyric acid receptor subunit rho-1", "gene_name": "Gabrr1", "organism": "Mouse", "refseq_name": "gamma-aminobutyric acid receptor subunit rho-1 precursor", "refseq_ac": "NP_032101", "gene_names_uniprotkb": "Gabrr1", "gene_names_refseq": "GABA-C; Gabrr1", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit rho-1; GABA(A) receptor subunit rho-1; GABA(C) receptor; GABAAR subunit rho-1", "protein_names_refseq": "GABA(A) receptor subunit rho-1; GABA(C) receptor; GABAAR subunit rho-1; gamma-aminobutyric acid (GABA) C receptor, subunit rho 1; gamma-aminobutyric acid (GABA-A) receptor, subunit rho 1; gamma-aminobutyric acid receptor subunit rho-1 precursor; gamma-aminobutyric acid receptor subunit rho-1", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:14408); (R-MMU-977443)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16945976;25422464;31451629", "class_list": "", "function": "GABRR1 is a rho subunit receptor of GABA, the major inhibitory neurotransmitter in the mammalian brain. The GABA receptor GABRR1 is expressed on and functional in hematopoietic stem cells and megakaryocyte progenitors., [RefSeq, PubMed]; Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain. Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces. When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Rho-1 subunits are primarily expressed in retina where rho-1-containing GABAARs play a role in retinal neurotransmission (By similarity). Rho-1 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (PubMed:16945976). Rho-1 GABAARs may also contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (PubMed:25422464)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A3KG51", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0097708 intracellular vesicle;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56475-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63213-1", "uniprot_id": "GBG2_MOUSE", "mass": 7850.0, "length": 71, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2", "gene_name": "Gng2", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2", "refseq_ac": "NP_001033726", "gene_names_uniprotkb": "Gng2", "gene_names_refseq": "Gng2; Hg3f1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; G gamma-I", "protein_names_refseq": "g gamma-I; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; heterotrimeric guanine nucleotide-binding protein 3f1", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14702); (R-MMU-1296041); (R-MMU-202040); (R-MMU-381676); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 28, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10191100;17114649;26495903;27074662;32152506;33655887;38270191;8858601", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (By similarity). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity)., [UniProtKB, UniProtKB]; It was concluded that GIRK2, through its dual responsiveness to G protein beta-gamma and Na+, mediates a form of neuronal inhibition that is amplifiable in the setting of excess electrical activity. Publication Status: Online-Only, [RefSeq, PubMed]; MiRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are involved in the pathogenesis of abdominal aortic aneurysm in mice., [RefSeq, PubMed]; The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the gamma-Subunit Gng2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P16874;Q3TYE8;Q61013;Q9TS47", "ec_number_list": "", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P63213-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01514-1", "uniprot_id": "GBP1_MOUSE", "mass": 67712.0, "length": 589, "protein_name": "Guanylate-binding protein 1", "gene_name": "Gbp1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gbp1; Gbp-1; Mag-1; Mpa1", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanylate-binding protein 1; 3.6.1.-; 3.6.5.-; GBP-1; GTP-binding protein 1; Guanine nucleotide-binding protein 1; Interferon-gamma-inducible protein MAG-1; Interferon-induced guanylate-binding protein 1; mGBP-1; mGBP1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 12, "publication_id_list": "10888661;1715024;1753106;18025219;21551061;24715728;24739961;25428506;25428507;31219806;34428180;36210013", "class_list": "", "function": "Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:18025219, PubMed:21551061, PubMed:24715728, PubMed:24739961). Hydrolyzes GTP to GMP in two consecutive cleavage reactions: GTP is first hydrolyzed to GDP and then to GMP in a processive manner (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and promotes both inflammasome assembly and autophagy (PubMed:21551061, PubMed:24715728, PubMed:24739961). Acts as a positive regulator of inflammasome assembly by facilitating the detection of inflammasome ligands from pathogens (PubMed:24715728, PubMed:24739961). Involved in the lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24715728, PubMed:24739961). Following pathogen release in the cytosol, forms a protein coat in a GTPase-dependent manner that encapsulates pathogens and promotes the detection of ligands by pattern recognition receptors (By similarity). Plays a key role in inflammasome assembly in response to infection by Gram-negative bacteria: following pathogen release in the cytosol, forms a protein coat that encapsulates Gram-negative bacteria and directly binds to lipopolysaccharide (LPS), disrupting the O-antigen barrier and unmasking lipid A that is that detected by the non-canonical inflammasome effector CASP4/CASP11 (PubMed:24715728, PubMed:24739961). Also promotes recruitment of proteins that mediate bacterial cytolysis, leading to release double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24715728, PubMed:24739961). Involved in autophagy by regulating bacteriolytic peptide generation via its interaction with ubiquitin-binding protein SQSTM1, which delivers monoubiquitinated proteins to autolysosomes for the generation of bacteriolytic peptides (PubMed:21551061). Confers protection to several pathogens, including the bacterial pathogens L.monocytogenes and M.bovis BCG as well as the protozoan pathogen T.gondii (PubMed:18025219, PubMed:21551061). Exhibits antiviral activity against influenza virus (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32MT4", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;3.6.1.6;2.7.11.1;3.6.-.-;3.6.1.42", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001530 lipopolysaccharide binding;GO:0004382 GDP phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0051607 defense response to virus;GO:0071222 cellular response to lipopolysaccharide;GO:0042742 defense response to bacterium;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q01514-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05915-1", "uniprot_id": "GCH1_MOUSE", "mass": 27014.0, "length": 241, "protein_name": "GTP cyclohydrolase 1", "gene_name": "Gch1", "organism": "Mouse", "refseq_name": "GTP cyclohydrolase 1", "refseq_ac": "NP_032128", "gene_names_uniprotkb": "Gch1; Gch", "gene_names_refseq": "GTP-CH-I; GTP-CH; GTPCH; Gch1; Gch", "protein_names_uniprotkb": "GTP cyclohydrolase 1; 3.5.4.16; GTP cyclohydrolase I; GTP-CH-I", "protein_names_refseq": "GTP cyclohydrolase 1; GTP cyclohydrolase I", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); dopa-responsive dystonia (Disease Ontology:DOID:0090043); BH4-deficient hyperphenylalaninemia B (Disease Ontology:DOID:0112225); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); transient cerebral ischemia (Disease Ontology:DOID:224); bipolar disorder (Disease Ontology:DOID:3312); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); pulmonary fibrosis (Disease Ontology:DOID:3770); liver cirrhosis (Disease Ontology:DOID:5082); intestinal disease (Disease Ontology:DOID:5295); dystonia (Disease Ontology:DOID:543); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:14528); (R-MMU-1474151)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "17242355;21183079;31219806;32152506;33109704;34203471;34428180;36210013;36443440;8304101;8461009", "class_list": "", "function": "May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence., [UniProtKB, UniProtKB]; SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.4.16", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0032496 response to lipopolysaccharide;GO:0034612 response to tumor necrosis factor;GO:0008217 regulation of blood pressure;GO:0042311 vasodilation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q05915-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q32M02-1", "uniprot_id": "FSCN2_MOUSE", "mass": 55073.0, "length": 492, "protein_name": "Fascin-2", "gene_name": "Fscn2", "organism": "Mouse", "refseq_name": "fascin-2", "refseq_ac": "NP_766390", "gene_names_uniprotkb": "Fscn2", "gene_names_refseq": "A930022G03; Ahl8; C630046B20Rik; Fscn2", "protein_names_uniprotkb": "Fascin-2; Retinal fascin", "protein_names_refseq": "fascin homolog 2, actin-bundling protein, retinal; fascin-2; retinal fascin", "tax_id": 10090, "disease": "retinitis pigmentosa 30 (Disease Ontology:DOID:0110406); retinitis pigmentosa (Disease Ontology:DOID:10584); auditory system disease (Disease Ontology:DOID:2742); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:238021)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20660251;23658152;27811163;28369442;30082328", "class_list": "", "function": "Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Important for maintaining functional hair-cell bundles in the inner ear. May stiffen the longer stereocilia of hair-cell bundles in the inner ear enabling better force transmission to tip links., [UniProtKB, PubMed]; Mutation in the Fscn2 gene underlies the early onset progressive hearing loss of DBA/2J mice attributed to the ahl8 locus., [RefSeq, PubMed]; The results of this study demonistrated that fascin-2 crosslinks function to slow actin depolymerization at stereocilia tips to maintain stereocilia length., [RefSeq, PubMed]; The results show that cross-talk through CD40-CD40L signaling drives elevated fascin expression in DCs to support acquisition of full T-cell responses., [RefSeq, PubMed]; These results demonstrate that, in C57BL/6Jmice, Fscn2 is essential for maintaining ear and eye function and that a null mutation of Fscn2 leads to progressive hearing loss and retinal degeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWU0", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0032420 stereocilium", "go_biological_process": "GO:0016477 cell migration;GO:0030036 actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0007163 establishment or maintenance of cell polarity;GO:0042462 eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q32M02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3SXG2-1", "uniprot_id": "FPRS6_MOUSE", "mass": 38154.0, "length": 339, "protein_name": "Formyl peptide receptor-related sequence 6", "gene_name": "Fpr-rs6", "organism": "Mouse", "refseq_name": "formyl peptide receptor-related sequence 6", "refseq_ac": "NP_796290", "gene_names_uniprotkb": "Fpr-rs6", "gene_names_refseq": "Fpr-rs6", "protein_names_uniprotkb": "Formyl peptide receptor-related sequence 6", "protein_names_refseq": "formyl peptide receptor-related sequence 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:321020); (R-MMU-418594); (R-MMU-444473)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12459252;19387439;19497865", "class_list": "", "function": "May have an olfactory function associated with the identification of pathogens or of pathogenic states., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q71MR8", "ec_number_list": "", "go_molecular_function": "GO:0004875 complement receptor activity;GO:0004982 N-formyl peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3SXG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UFD7-1", "uniprot_id": "FFAR3_MOUSE", "mass": 36501.0, "length": 319, "protein_name": "Free fatty acid receptor 3", "gene_name": "Ffar3", "organism": "Mouse", "refseq_name": "free fatty acid receptor 3", "refseq_ac": "NP_001028488", "gene_names_uniprotkb": "Ffar3; Gm478; Gpr41", "gene_names_refseq": "Ffar3; Gm478; Gpr41", "protein_names_uniprotkb": "Free fatty acid receptor 3; G protein-coupled receptor 41", "protein_names_refseq": "G-protein coupled receptor 41; free fatty acid receptor 3; putative G protein-coupled receptor GPR41", "tax_id": 10090, "disease": "", "pathway": " (mmu:233080); (R-MMU-416476); (R-MMU-444209)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "14722361;16123168;18931303;19009545;20399779;21518883;22190648;22673524;23066016;23110765;23401498;23665276;24748202;38524121", "class_list": "", "function": "Acetate and propionate short chain fatty acids may have important physiological roles in adipogenesis through GPCR43, but not through GPCR41., [RefSeq, PubMed]; G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate (PubMed:21518883, PubMed:22673524). Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion (PubMed:23401498). May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota (PubMed:18931303). May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine (PubMed:14722361, PubMed:20399779). Finally, may also play a role in glucose homeostasis (PubMed:22190648, PubMed:24748202). Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells (PubMed:23665276). Exhibits an SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; GPR41 and GPR43 regulate CD8[+] T cell priming during herpes simplex virus type 1 infection. Publication Status: Online-Only, [RefSeq, PubMed]; Gpr41 is a regulator of host energy balance through effects that are dependent upon the gut microbiota, [RefSeq, PubMed]; In this review, the mechanism of receptor activation, pharmacology, and the physiological functions of the fatty acid binding receptors GPR40, GPR41, GPR43, and GPR119 are discussed. Review article, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0014061 regulation of norepinephrine secretion;GO:0032722 positive regulation of chemokine production", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q3UFD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UFT3-1", "uniprot_id": "GARE1_MOUSE", "mass": 97250.0, "length": 876, "protein_name": "GRB2-associated and regulator of MAPK protein", "gene_name": "Garem1", "organism": "Mouse", "refseq_name": "GRB2-associated and regulator of MAPK protein", "refseq_ac": "NP_001028617", "gene_names_uniprotkb": "Garem1; Fam59a; Garem; Gm944; Kiaa4238", "gene_names_refseq": "Fam59a; Garem1; Garem; Gm944; mKIAA4238", "protein_names_uniprotkb": "GRB2-associated and regulator of MAPK protein; GRB2-associated and regulator of MAPK1", "protein_names_refseq": "GRB2 associated, regulator of MAPK1; GRB2-associated and regulator of MAPK protein; GRB2-associated and regulator of MAPK1; family with sequence similarity 59, member A; protein FAM59A", "tax_id": 10090, "disease": "", "pathway": " (mmu:381126)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;24003223;30084848;34428180;36084556", "class_list": "", "function": "Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity)., [UniProtKB]; Data indicate that a subtype of GAREM, GAREM2, is specifically expressed in the mouse, rat, and human brain., [RefSeq, PubMed]; GAREM1 is involved in controlling body mass in mice and humans., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G5E8B7;Q3TSA2;Q5DTF6;Q80V96", "ec_number_list": "", "go_molecular_function": "GO:0070064 proline-rich region binding", "go_cellular_component": "", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0008283 cell population proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UFT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3USW5-1", "uniprot_id": "FXRD2_MOUSE", "mass": 76004.0, "length": 665, "protein_name": "FAD-dependent oxidoreductase domain-containing protein 2", "gene_name": "Foxred2", "organism": "Mouse", "refseq_name": "FAD-dependent oxidoreductase domain-containing protein 2 precursor", "refseq_ac": "NP_001017983", "gene_names_uniprotkb": "Foxred2; D15Bwg0759e", "gene_names_refseq": "A430097D04Rik; D15Bwg0759e; Foxred2; Gm304", "protein_names_uniprotkb": "FAD-dependent oxidoreductase domain-containing protein 2", "protein_names_refseq": "FAD-dependent oxidoreductase domain-containing protein 2 precursor; FAD-dependent oxidoreductase domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:239554)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;18299400;21952136;22872234;30084848;34428180", "class_list": "", "function": "Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCC4;Q5RJH0", "ec_number_list": "", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3USW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DRQ8-1", "uniprot_id": "FCRLB_MOUSE", "mass": 47502.0, "length": 427, "protein_name": "Fc receptor-like B", "gene_name": "Fcrlb", "organism": "Mouse", "refseq_name": "Fc receptor-like B precursor", "refseq_ac": "NP_001025155", "gene_names_uniprotkb": "Fcrlb; Fcrl2; Fcrlm2; Fcry; Freb2", "gene_names_refseq": "FREB-2; FREB2; FcRL2; Fcrlb; Fcrlm2; Fcry; mFCRL2", "protein_names_uniprotkb": "Fc receptor-like B; FREB-2; Fc receptor homolog expressed in B-cells protein 2; Fc receptor-like and mucin-like protein 2; Fc receptor-like protein 2; Fc receptor-related protein Y; FcRY", "protein_names_refseq": "Fc receptor homolog expressed in B-cells protein 2; Fc receptor related Y; Fc receptor-like B precursor; Fc receptor-like mucin-like 2; fc receptor homolog expressed in B cells protein 2; fc receptor-like and mucin-like protein 2; fc receptor-like protein 2; fc receptor-related protein Y", "tax_id": 10090, "disease": "", "pathway": " (mmu:435653)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15815692;16263223;20869045;21068405", "class_list": "", "function": "A negative immunomodulatory function for FCRL2 in the regulation of memory B cells., [RefSeq, PubMed]; Fcry is upregulated by short-term treatment with BAFF/BLyS, which promotes B cell survival rather than proliferation, [RefSeq, PubMed]; In FCRLB knock-out mice, B-cell developmemt and in vitro response were normal, but in vivo antibody responses to a T-dependent antigen were elevated. The latter response may be due to a promoter polymorphism in the 129/Sv knock-out strain's Fcgr2b allele., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F8VQL1", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0050777 negative regulation of immune response;GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5DRQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F2L2-1", "uniprot_id": "OFUT3_MOUSE", "mass": 55707.0, "length": 481, "protein_name": "GDP-fucose protein O-fucosyltransferase 3", "gene_name": "Pofut3", "organism": "Mouse", "refseq_name": "GDP-fucose protein O-fucosyltransferase 3 isoform a", "refseq_ac": "NP_001012535", "gene_names_uniprotkb": "Pofut3; Fut10", "gene_names_refseq": "Fut10; Pofut3; fuc-TX; fut10A", "protein_names_uniprotkb": "GDP-fucose protein O-fucosyltransferase 3; 2.4.1.-; 2.4.1.221; Alpha-(1,3)-fucosyltransferase 10; Fuc-TX; FucT-X; Fucosyltransferase 10; Fucosyltransferase X; Galactoside 3-L-fucosyltransferase 10", "protein_names_refseq": "GDP-fucose protein O-fucosyltransferase 3 isoform a; GDP-fucose protein O-fucosyltransferase 3; alpha-(1,3)-fucosyltransferase 10; fucosyltransferase X; galactoside 3-L-fucosyltransferase 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:171167); (R-MMU-5173105)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12370785;23986452;34257163", "class_list": "glycogene;glycosyltransferase", "function": "CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9., [RefSeq, PubMed]; Fut10 is involved in a unique alpha1,3-fucosyltransferase activity with stringent substrate specificity., [RefSeq, PubMed]; Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1 (By similarity). Attaches fucose through an O-glycosidic linkage (By similarity). O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion (By similarity). May also show alpha-(1,3)-fucosyltransferase activity toward the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors (By similarity). However, this was tested with a library of synthetic substrates and this activity is unsure in vivo (By similarity). May be involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (PubMed:23986452)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8C457;Q8K0S3;Q8R247", "ec_number_list": "2.4.1.221;2.4.1.-", "go_molecular_function": "GO:0046922 peptide-O-fucosyltransferase activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050714 positive regulation of protein secretion;GO:0006491 N-glycan processing;GO:0036445 neuronal stem cell division", "synthesized_glycan_count": 1641, "hit_score": 0.7, "record_id": "Q5F2L2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5STE3-1", "uniprot_id": "FSTL4_MOUSE", "mass": 92579.0, "length": 841, "protein_name": "Follistatin-related protein 4", "gene_name": "Fstl4", "organism": "Mouse", "refseq_name": "follistatin-related protein 4 precursor", "refseq_ac": "NP_796033", "gene_names_uniprotkb": "Fstl4; Kiaa1061", "gene_names_refseq": "B230374F23Rik; Fstl4; SPIG1; mKIAA1061", "protein_names_uniprotkb": "Follistatin-related protein 4; Follistatin-like protein 4; m-D/Bsp120I 1-1", "protein_names_refseq": "follistatin-like protein 4; follistatin-related protein 4 precursor; follistatin-related protein 4; m-D/Bsp120I 1-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:320027)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;24573299", "class_list": "", "function": "This study demonistrated that SPIG1 negatively regulates BDNF maturation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9462, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2RT35;Q5DU03", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0048403 brain-derived neurotrophic factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0030141 secretory granule", "go_biological_process": "GO:0030154 cell differentiation;GO:0030510 regulation of BMP signaling pathway;GO:0061000 negative regulation of dendritic spine development;GO:0048671 negative regulation of collateral sprouting;GO:0031549 negative regulation of brain-derived neurotrophic factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5STE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60687-1", "uniprot_id": "FSHB_MOUSE", "mass": 14919.0, "length": 130, "protein_name": "Follitropin subunit beta", "gene_name": "Fshb", "organism": "Mouse", "refseq_name": "follitropin subunit beta precursor", "refseq_ac": "NP_032071", "gene_names_uniprotkb": "Fshb", "gene_names_refseq": "FSH-B; FSH-beta; FSH; Fshbeta; Fshb", "protein_names_uniprotkb": "Follitropin subunit beta; FSH-B; FSH-beta; Follicle-stimulating hormone beta subunit; Follitropin beta chain", "protein_names_refseq": "follicle-stimulating hormone beta subunit; follitropin beta chain; follitropin subunit beta precursor; follitropin subunit beta", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 24 without anosmia (Disease Ontology:DOID:0090088); amenorrhea (Disease Ontology:DOID:13938); severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (mmu:14308); (R-MMU-209822); (R-MMU-375281); (R-MMU-418555)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11416011;23371388;37208854;8543187;9020850", "class_list": "", "function": "Identification of follicle-stimulating hormone-responsive genes in Sertoli cells during early postnatal mouse testis development., [RefSeq, PubMed]; The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. [provided by RefSeq, Aug 2015]., [RefSeq]; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:11416011, PubMed:9020850)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016913 follicle-stimulating hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016914 follicle-stimulating hormone complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0045780 positive regulation of bone resorption", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q60687-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60688-1", "uniprot_id": "FOXD4_MOUSE", "mass": 48047.0, "length": 444, "protein_name": "Forkhead box protein D4", "gene_name": "Foxd4", "organism": "Mouse", "refseq_name": "forkhead box protein D4", "refseq_ac": "NP_032048", "gene_names_uniprotkb": "Foxd4; Fkh2; Fkhl9; Freac5", "gene_names_refseq": "FREAC5; Fkh2; Foxd4", "protein_names_uniprotkb": "Forkhead box protein D4; FREAC-5; Forkhead-related protein FKHL9; Forkhead-related transcription factor 5; Transcription factor FKH-2", "protein_names_refseq": "FREAC-5; forkhead box protein D4; forkhead homolog 2; forkhead-related protein FKHL9; forkhead-related transcription factor 5; transcription factor FKH-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:14237)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "27092474;7689224;8530406", "class_list": "", "function": "We demonstrate that mouse and human homologs of Foxd4l1 have similar functional domains compared to the frog protein, as well as conserved transcriptional activities when expressed in Xenopus embryos and blastomere explants., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRJ0;Q61573", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q60688-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61017-1", "uniprot_id": "GBGT2_MOUSE", "mass": 7802.0, "length": 69, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2", "gene_name": "Gngt2", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2", "refseq_ac": "NP_001033753", "gene_names_uniprotkb": "Gngt2; Gng8; Gngt8", "gene_names_refseq": "Gngt2; Hg3i", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2; G gamma-C; G-gamma-8", "protein_names_refseq": "G-gamma-8; g gamma-C; guanine nucleotide binding protein (G protein), gamma transducing polypeptide 2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2; heterotrimeric guanine nucleotide-binding protein 3i", "tax_id": 10090, "disease": "", "pathway": " (mmu:14710); (R-MMU-1296041); (R-MMU-202040); (R-MMU-381676); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 28, "publication_count": 3, "publication_id_list": "32152506;35897046;8858601", "class_list": "", "function": "Deletion of Abi3/Gngt2 influences age-progressive amyloid beta and tau pathologies in distinctive ways. Publication Status: Online-Only, [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWL5", "ec_number_list": "", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q61017-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61080-1", "uniprot_id": "FOXF1_MOUSE", "mass": 39958.0, "length": 378, "protein_name": "Forkhead box protein F1", "gene_name": "Foxf1", "organism": "Mouse", "refseq_name": "forkhead box protein F1", "refseq_ac": "NP_034556", "gene_names_uniprotkb": "Foxf1; Fkhl5; Foxf1a; Freac1; Hfh8", "gene_names_refseq": "FREAC1; Foxf1a; Foxf1; Freac-1; HFH-8; Hfh8", "protein_names_uniprotkb": "Forkhead box protein F1; FREAC-1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1; HFH-8; Hepatocyte nuclear factor 3 forkhead homolog 8", "protein_names_refseq": "HNF-3/forkhead homolog 8; forkhead box F1a; forkhead box protein F1; forkhead-related protein FKHL5; forkhead-related transcription factor 1; hepatocyte nuclear factor 3 forkhead homolog 8", "tax_id": 10090, "disease": "persistent fetal circulation syndrome (Disease Ontology:DOID:13042)", "pathway": " (mmu:15227)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11313147;34203471;7958446;8626802", "class_list": "", "function": "Probable transcription activator for a number of lung-specific genes., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RSC1;Q61661", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q61080-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61572-1", "uniprot_id": "FOXC1_MOUSE", "mass": 56940.0, "length": 553, "protein_name": "Forkhead box protein C1", "gene_name": "Foxc1", "organism": "Mouse", "refseq_name": "forkhead box protein C1", "refseq_ac": "NP_032618", "gene_names_uniprotkb": "Foxc1; Fkh1; Fkhl7; Freac3; Mf1", "gene_names_refseq": "FREAC3; Fkh1; Foxc1; Mf1; Mf4; ch; fkh-1; frkhda", "protein_names_uniprotkb": "Forkhead box protein C1; FREAC-3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; MF-1; Mesoderm/mesenchyme forkhead 1; Transcription factor FKH-1", "protein_names_refseq": "FREAC-3; MF-1; congenital hydrocephalus; forkhead box protein C1; forkhead-related protein FKHL7; forkhead-related transcription factor 3; mesoderm/mesenchyme forkhead 1; transcription factor FKH-1", "tax_id": 10090, "disease": "anterior segment dysgenesis 3 (Disease Ontology:DOID:0080608); Axenfeld-Rieger syndrome type 3 (Disease Ontology:DOID:0110122); buphthalmos (Disease Ontology:DOID:11211); Axenfeld-Rieger syndrome (Disease Ontology:DOID:14686); glaucoma (Disease Ontology:DOID:1686); invasive ductal carcinoma (Disease Ontology:DOID:3008); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:17300)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10395790;10479458;10704385;11562355;15196959;16449236;18187037;19668217;20665223;21183079;22171010;22493429;24590069;25808752;26565916;28223138;31219806;32782141;34428180;39012257;7689224;8375339;9106663;9635428;9767123", "class_list": "", "function": "DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:10395790, PubMed:10479458, PubMed:11562355, PubMed:18187037, PubMed:19668217, PubMed:22493429, PubMed:24590069, PubMed:25808752, PubMed:28223138, PubMed:9106663, PubMed:9635428). Acts either as a transcriptional activator or repressor (PubMed:28223138). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:25808752). Upon DNA-binding, promotes DNA bending. Acts as a transcriptional coactivator (PubMed:25808752). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (PubMed:25808752). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (By similarity). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (PubMed:28223138). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (By similarity). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (PubMed:18187037). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (By similarity). Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage (PubMed:10395790, PubMed:10479458, PubMed:10704385, PubMed:11562355, PubMed:15196959, PubMed:9106663). Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC) (PubMed:24590069). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner (PubMed:22171010). May function as a tumor suppressor (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88409;Q61582;Q9QWR9", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000792 heterochromatin", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0048341 paraxial mesoderm formation;GO:1901491 negative regulation of lymphangiogenesis;GO:1902257 negative regulation of apoptotic process involved in outflow tract morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q61572-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61574-1", "uniprot_id": "FOXS1_MOUSE", "mass": 35567.0, "length": 329, "protein_name": "Forkhead box protein S1", "gene_name": "Foxs1", "organism": "Mouse", "refseq_name": "forkhead box protein S1", "refseq_ac": "NP_034356", "gene_names_uniprotkb": "Foxs1; Fkh3; Fkhl18; Freac10", "gene_names_refseq": "FREAC10; Fkh3; Fkhl18; Foxs1", "protein_names_uniprotkb": "Forkhead box protein S1; FREAC-10; Forkhead-like 18 protein; Forkhead-related transcription factor 10; Transcription factor FKH-3", "protein_names_refseq": "FREAC-10; forkhead box protein S1; forkhead-like 18 protein; forkhead-related transcription factor 10; transcription factor FKH-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:14239)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18288644;25289806;30918291;35820727;38280429;7689224", "class_list": "", "function": "FOXS1 is increased in liver fibrosis and regulates TGFbeta responsiveness and proliferation pathways in human hepatic stellate cells., [RefSeq, PubMed]; FOXS1 is regulated by GLI1 and miR-125a-5p and promotes cell proliferation and EMT in gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Genome-wide methylation analysis showed that two genes with hypomethylated promoters, Igfbp6 and Foxs1, are upregulated in GDX-induced adrenocortical neoplasms., [RefSeq, PubMed]; Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5N7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0050885 neuromuscular process controlling balance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q61574-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64731-1", "uniprot_id": "FOXL1_MOUSE", "mass": 35793.0, "length": 336, "protein_name": "Forkhead box protein L1", "gene_name": "Foxl1", "organism": "Mouse", "refseq_name": "forkhead box protein L1", "refseq_ac": "NP_032050", "gene_names_uniprotkb": "Foxl1; Fkh6; Fkhl11", "gene_names_refseq": "FREAC7; Fkh6; Foxl1; fkh-6", "protein_names_uniprotkb": "Forkhead box protein L1; Forkhead-related protein FKHL11; Transcription factor FKH-6", "protein_names_refseq": "forkhead box protein L1; forkhead homolog 6; forkhead-related protein FKHL11; transcription factor FKH-6", "tax_id": 10090, "disease": "otosclerosis 11 (Disease Ontology:DOID:0060928); osteoporosis (Disease Ontology:DOID:11476); otosclerosis (Disease Ontology:DOID:12185)", "pathway": " (mmu:14241)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15155178;19049965;7689224;8674414;9203584", "class_list": "", "function": "Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 and GLI3 transcription factors., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RQ86", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007495 visceral mesoderm-endoderm interaction involved in midgut development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q64731-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64732-1", "uniprot_id": "FOXB1_MOUSE", "mass": 35008.0, "length": 325, "protein_name": "Forkhead box protein B1", "gene_name": "Foxb1", "organism": "Mouse", "refseq_name": "forkhead box protein B1", "refseq_ac": "NP_071773", "gene_names_uniprotkb": "Foxb1; Fkh5; Foxb1a; Foxb1b; Mf3", "gene_names_refseq": "C43; Fkh5; Foxb1a; Foxb1b; Foxb1; Hfh-e5.1; Mf3; Twh", "protein_names_uniprotkb": "Forkhead box protein B1; Transcription factor FKH-5", "protein_names_refseq": "forkhead box B1a; forkhead box B1b; forkhead box protein B1; mesoderm/mesenchyme forkhead 3; transcription factor FKH-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:64290)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11170346;15654859;25428506;27292133;28725186;36210013;7689224;8306889;8861101", "class_list": "", "function": "Transcription factor expressed by neural progenitor cells in specific regions of the embryonic neuroepithelium (PubMed:15654859, PubMed:28725186). Essential for the mammillary nuclei maintenance (PubMed:15654859). Negatively regulates the proliferation of oligodendrocyte progenitors and promotes oligodendrocyte maturation (PubMed:28725186). Also expressed in mammary glands, plays a role in lactation, controls development of mammary glands and the inferior colliculi of the midbrain in the central nervous system that regulates the milk-ejection reflex (PubMed:11170346)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08753;Q2M2M4", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008542 visual learning;GO:0021510 spinal cord development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64732-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64733-1", "uniprot_id": "FOXB2_MOUSE", "mass": 45170.0, "length": 428, "protein_name": "Forkhead box protein B2", "gene_name": "Foxb2", "organism": "Mouse", "refseq_name": "forkhead box protein B2", "refseq_ac": "NP_032049", "gene_names_uniprotkb": "Foxb2; Fkh4", "gene_names_refseq": "Fkh4; Foxb2", "protein_names_uniprotkb": "Forkhead box protein B2; Transcription factor FKH-4", "protein_names_refseq": "forkhead box protein B2; forkhead homolog 4; transcription factor FKH-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:14240)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7689224;8861101", "class_list": "", "function": "Transcription factor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64733-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q71MR7-1", "uniprot_id": "FPRS7_MOUSE", "mass": 38141.0, "length": 338, "protein_name": "Formyl peptide receptor-related sequence 7", "gene_name": "Fpr-rs7", "organism": "Mouse", "refseq_name": "formyl peptide receptor-related sequence 7", "refseq_ac": "XP_030106054", "gene_names_uniprotkb": "Fpr-rs7", "gene_names_refseq": "Fpr-rs7", "protein_names_uniprotkb": "Formyl peptide receptor-related sequence 7", "protein_names_refseq": "formyl peptide receptor-related sequence 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:321021); (R-MMU-418594); (R-MMU-444473)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12459252;19387439;19497865", "class_list": "", "function": "May have an olfactory function associated with the identification of pathogens or of pathogenic states., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3X9N8", "ec_number_list": "", "go_molecular_function": "GO:0004875 complement receptor activity;GO:0004982 N-formyl peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q71MR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFQ8-1", "uniprot_id": "GALD1_MOUSE", "mass": 23277.0, "length": 220, "protein_name": "Glutamine amidotransferase-like class 1 domain-containing protein 1", "gene_name": "Gatd1", "organism": "Mouse", "refseq_name": "glutamine amidotransferase-like class 1 domain-containing protein 1 precursor", "refseq_ac": "NP_742114", "gene_names_uniprotkb": "Gatd1; Pddc1", "gene_names_refseq": "D230016J19Rik; Fy-5; Gatd1; Pddc1", "protein_names_uniprotkb": "Glutamine amidotransferase-like class 1 domain-containing protein 1; Ferry endosomal RAB5 effector complex subunit 5; Fy-5; Parkinson disease 7 domain-containing protein 1", "protein_names_refseq": "Parkinson disease 7 domain containing 1; ferry endosomal RAB5 effector complex subunit 5; glutamine amidotransferase-like class 1 domain-containing protein 1 precursor; glutamine amidotransferase-like class 1 domain-containing protein 1; parkinson disease 7 domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:213350)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;25428506;30084848;31219806;34428180", "class_list": "", "function": "Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2Q9", "ec_number_list": "", "go_molecular_function": "GO:0019172 glyoxalase III activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BFQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHD4-1", "uniprot_id": "FRMD3_MOUSE", "mass": 68448.0, "length": 595, "protein_name": "FERM domain-containing protein 3", "gene_name": "Frmd3", "organism": "Mouse", "refseq_name": "FERM domain-containing protein 3 isoform 2", "refseq_ac": "NP_001157204", "gene_names_uniprotkb": "Frmd3", "gene_names_refseq": "4.1O; 9430066I12Rik; EPB41L4O; Frmd3; P410", "protein_names_uniprotkb": "FERM domain-containing protein 3", "protein_names_refseq": "FERM domain-containing protein 3 isoform 2; FERM domain-containing protein 3", "tax_id": 10090, "disease": "triple-receptor negative breast cancer (Disease Ontology:DOID:0060081); neurodevelopmental disorder with eye movement abnormalities and ataxia (Disease Ontology:DOID:0081275)", "pathway": " (mmu:242506)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;17114649;38959315", "class_list": "", "function": "Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer., [UniProtKB]; Tumor suppressor FRMD3 controls mammary epithelial cell fate determination via notch signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2BEJ6;Q3UF23;Q5SPU0;Q5SPU1;Q8C045", "ec_number_list": "", "go_molecular_function": "GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BHD4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C7U7-1", "uniprot_id": "GALT6_MOUSE", "mass": 71537.0, "length": 622, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 6", "gene_name": "Galnt6", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 6", "refseq_ac": "NP_001155239", "gene_names_uniprotkb": "Galnt6", "gene_names_refseq": "4632410F13; GalNAc-T6; Galnt6", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 6; 2.4.1.41; GalNAc-T6; Polypeptide GalNAc transferase 6; Protein-UDP acetylgalactosaminyltransferase 6; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6; pp-GaNTase 6", "protein_names_refseq": "N-acetylgalactosaminyltransferase T-6; Protein-UDP acetylgalactosaminyltransferase 6; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6; polypeptide GalNAc transferase 6; polypeptide N-acetylgalactosaminyltransferase 6; pp-GaNTase 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:207839); (R-MMU-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10464263", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides (By similarity)., [UniProtKB, UniProtKB]; This paper describes the identification and cloning of the orthologous human enzyme of mouse UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VE84;Q3TWF0;Q8CED2;Q9QZ16", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 0.2, "record_id": "Q8C7U7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CBY0-1", "uniprot_id": "GATC_MOUSE", "mass": 16667.0, "length": 155, "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial", "gene_name": "Gatc", "organism": "Mouse", "refseq_name": "glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial", "refseq_ac": "NP_083921", "gene_names_uniprotkb": "Gatc", "gene_names_refseq": "2010003O18Rik; Gatc", "protein_names_uniprotkb": "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; 6.3.5.-; Glu-AdT subunit C", "protein_names_refseq": "gatC-like protein; glu-AdT subunit C; glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; glutamyl-tRNA(Gln) amidotransferase, subunit C homolog", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 42 (Disease Ontology:DOID:0112118)", "pathway": " (mmu:384281)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24579914", "class_list": "", "function": "Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)., [UniProtKB, HAMAP]; Glutamyl-tRNA Gln amidotransferase subunit interference produces a strong defect in mitochondrial translation without affecting the stability of the newly synthesized proteins. ., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VC59;Q9D8F4", "ec_number_list": "6.3.5.-;6.3.5.7", "go_molecular_function": "GO:0005524 ATP binding;GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CBY0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91X44-2", "uniprot_id": "GCKR_MOUSE", "mass": 68721.0, "length": 623, "protein_name": "Glucokinase regulatory protein", "gene_name": "Gckr", "organism": "Mouse", "refseq_name": "glucokinase regulatory protein isoform 2", "refseq_ac": "NP_659158", "gene_names_uniprotkb": "Gckr", "gene_names_refseq": "GKRP; Gckr", "protein_names_uniprotkb": "Glucokinase regulatory protein; GKRP; Glucokinase regulator", "protein_names_refseq": "glucokinase regulatory protein isoform 2; glucokinase regulator", "tax_id": 10090, "disease": "end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:231103); (R-MMU-170822)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10713097;30084848;37031802;37453647;38972375", "class_list": "", "function": "Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency., [RefSeq, PubMed]; Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:10713097). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10713097). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (By similarity)., [UniProtKB, UniProtKB, PubMed]; The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0J9YUI8", "ec_number_list": "", "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046415 urate metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0034504 protein localization to nucleus;GO:0009749 response to glucose;GO:0070328 triglyceride homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91X44-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XW8-1", "uniprot_id": "FKBP6_MOUSE", "mass": 37125.0, "length": 327, "protein_name": "Inactive peptidyl-prolyl cis-trans isomerase FKBP6", "gene_name": "Fkbp6", "organism": "Mouse", "refseq_name": "inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform 1", "refseq_ac": "NP_001264820", "gene_names_uniprotkb": "Fkbp6; Fkbp36", "gene_names_refseq": "1700008G22Rik; 36kDa; D5Ertd724e; FKBP-36; FKBP-6; Fkbp6", "protein_names_uniprotkb": "Inactive peptidyl-prolyl cis-trans isomerase FKBP6; 36 kDa FK506-binding protein; 36 kDa FKBP; FK506-binding protein 6; FKBP-36; FKBP-6; Immunophilin FKBP36; Inactive PPIase FKBP6", "protein_names_refseq": "36 kDa FK506-binding protein; 36 kDa FKBP; PPIase FKBP6; immunophilin FKBP36; inactive PPIase FKBP6; inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform 1; inactive peptidyl-prolyl cis-trans isomerase FKBP6; peptidyl-prolyl cis-trans isomerase FKBP6; rotamase", "tax_id": 10090, "disease": "spermatogenic failure 77 (Disease Ontology:DOID:0070576); male infertility (Disease Ontology:DOID:12336); Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:94244)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12764197;18408354;22902560", "class_list": "", "function": "Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes., [UniProtKB, PubMed, PubMed, PubMed]; Fkbp6 is a component of the synaptonemal complex essential for sex-specific fertility and for the fidelity of homologous chromosome pairing in meiosis, [RefSeq, PubMed]; This gene is a member of the FK506-binding protein (Fkbp) family. The encoded protein plays a role in male-specific fertility and homologous pairing of chromosomes during meiosis. The protein may also be involved in LINE1 transposon silencing and binding to Hsp90 as a co-chaperone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1Y1;Q91VB7;Q91Y30", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006457 protein folding;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0034587 piRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91XW8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922I5-1", "uniprot_id": "FOXI1_MOUSE", "mass": 40798.0, "length": 372, "protein_name": "Forkhead box protein I1", "gene_name": "Foxi1", "organism": "Mouse", "refseq_name": "forkhead box protein I1", "refseq_ac": "NP_076396", "gene_names_uniprotkb": "Foxi1", "gene_names_refseq": "5830401E05Rik; FREAC6; Fkh10; Foxi1; HFH-3; Hfh3", "protein_names_uniprotkb": "Forkhead box protein I1", "protein_names_refseq": "HNF-3/forkhead homolog 3; forkhead box protein I1; forkhead homolog 10", "tax_id": 10090, "disease": "Pendred Syndrome (Disease Ontology:DOID:0060744); autosomal recessive nonsyndromic deafness 4 (Disease Ontology:DOID:0110498)", "pathway": " (mmu:14233)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12642503;15173882;36603001", "class_list": "", "function": "The transcription factor Foxi1 promotes expression of V-ATPase and Gpr116 in M-1 cells., [RefSeq, PubMed]; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SRI5;Q9D299", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0042472 inner ear morphogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q922I5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5H4-1", "uniprot_id": "FTMT_MOUSE", "mass": 27158.0, "length": 237, "protein_name": "Ferritin, mitochondrial", "gene_name": "Ftmt", "organism": "Mouse", "refseq_name": "ferritin, mitochondrial precursor", "refseq_ac": "NP_080562", "gene_names_uniprotkb": "Ftmt", "gene_names_refseq": "4930447C24Rik; FerH; Fth3; Ftmt; MtF", "protein_names_uniprotkb": "Ferritin, mitochondrial; 1.16.3.1", "protein_names_refseq": "ferritin H; ferritin heavy chain 3; ferritin, mitochondrial precursor", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:67634); (R-MMU-917937)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15201052;15522954;25428506;27599360;28963372;31599954;31882562", "class_list": "", "function": "Age-related increase is found in FtMt and hypoxia-inducible factor-1a (HIF-1a) in murine retinal pigment epithelium (RPE).HIF-1alpha stabilization reduced the protein level of the mature, functional form of mitochondrial ferritin., [RefSeq, PubMed]; Catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation., [UniProtKB, PubMed]; In a model of FtMT overexpression, during dietary challenge, mice are leaner but exhibit glucose intolerance, low adiponectin levels, increased reactive oxygen species damage, and elevated GDF15 and FGF21 levels, indicating metabolically dysfunctional fat. Despite harboring highly dysfunctional fat, mice display massive beta-cell hyperplasia, reflecting a beneficial mitochondria-induced fat-to-pancreas interorgan signa..., [RefSeq, PubMed]; Lack of mitochondrial ferritin aggravated neurological deficits via enhancing oxidative stress in a traumatic brain injury murine model. Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression of MtFt causes a dramatic change in intracellular iron homeostasis and shunting iron to MtFt likely limits its availability for active iron proteins, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BZ8;Q3V0N6;Q9D5F4", "ec_number_list": "1.16.3.1;1.11.1.27;1.11.1.9;1.16.3.4", "go_molecular_function": "GO:0005506 iron ion binding;GO:0008198 ferrous iron binding;GO:0004322 ferroxidase activity;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0051604 protein maturation;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D5H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6K8-1", "uniprot_id": "FUND2_MOUSE", "mass": 16564.0, "length": 151, "protein_name": "FUN14 domain-containing protein 2", "gene_name": "Fundc2", "organism": "Mouse", "refseq_name": "FUN14 domain-containing protein 2", "refseq_ac": "NP_080402", "gene_names_uniprotkb": "Fundc2; Hcbp6", "gene_names_refseq": "4833415N24Rik; DC44; Fundc2; HCBP6", "protein_names_uniprotkb": "FUN14 domain-containing protein 2; Hepatitis C virus core-binding protein 6", "protein_names_refseq": "FUN14 domain-containing protein 2; hepatitis C virus core-binding protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:67391)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "27802388;29786068;30059200;30576423;32535386;34428180;35710796;36037337;37507081;37700593;39927985", "class_list": "", "function": "Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068, PubMed:30576423). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; FUNDC2 knockout mice carrying excessively apoptotic platelets exhibit thrombocytopenia in response to hypoxia., [RefSeq, PubMed]; FUNDC2 positively regulates platelet functions via AKT/GSK-3beta/cGMP signalling pathways., [RefSeq, PubMed]; FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion. Publication Status: Online-Only, [RefSeq, PubMed]; FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3beta/GLI1 pathway., [RefSeq, PubMed]; HCBP6 deficiency exacerbates glucose and lipid metabolism disorders in non-alcoholic fatty liver mice., [RefSeq, PubMed]; Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80VT2;Q80YD9;Q8BSM8;Q9D617", "ec_number_list": "", "go_molecular_function": "GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0010543 regulation of platelet activation;GO:0006351 DNA-templated transcription;GO:0000422 autophagy of mitochondrion;GO:0035356 intracellular triglyceride homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9D6K8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQC7-1", "uniprot_id": "FSTL3_MOUSE", "mass": 27271.0, "length": 256, "protein_name": "Follistatin-related protein 3", "gene_name": "Fstl3", "organism": "Mouse", "refseq_name": "follistatin-related protein 3 precursor", "refseq_ac": "NP_113557", "gene_names_uniprotkb": "Fstl3; Flrg", "gene_names_refseq": "E030038F23Rik; Flrg; Fstl3", "protein_names_uniprotkb": "Follistatin-related protein 3; Follistatin-like protein 3; Follistatin-related gene protein", "protein_names_refseq": "follistatin-like protein 3; follistatin-related gene protein; follistatin-related protein 3 precursor; follistatin-related protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:83554); (R-MMU-2473224); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11010968;11459787;12039070;17878677;31810141", "class_list": "", "function": "FSTL3 plays a biological role in the establishment and maintenance of normal pregnancy., [RefSeq, PubMed]; Genomic organization and promoter analysis, [RefSeq, PubMed]; The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048185 activin binding;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030141 secretory granule", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EQC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ER35-1", "uniprot_id": "FN3K_MOUSE", "mass": 35032.0, "length": 309, "protein_name": "Fructosamine-3-kinase", "gene_name": "Fn3k", "organism": "Mouse", "refseq_name": "fructosamine-3-kinase isoform a", "refseq_ac": "NP_071297", "gene_names_uniprotkb": "Fn3k", "gene_names_refseq": "2310074G21Rik; Fn3k", "protein_names_uniprotkb": "Fructosamine-3-kinase; 2.7.1.171; 2.7.1.172; Protein-psicosamine 3-kinase FN3K; Protein-ribulosamine 3-kinase FN3K", "protein_names_refseq": "fructosamine-3-kinase isoform a; protein-psicosamine 3-kinase FN3K; protein-ribulosamine 3-kinase FN3K", "tax_id": 10090, "disease": "", "pathway": " (mmu:63828); (R-MMU-163841)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11016445;15331600;16819943;20009024;29066600;31398338;34428180", "class_list": "", "function": "Data conclude that FN3K may play a key role in the GGap and thus diabetes complications such that FN3K may be a potential predictor of the risk of diabetes complications. Pharmacological modifications of its activity may provide a novel approach to their prevention., [RefSeq, PubMed]; FN3K is a targetable modulator of NRF2 activity in cancer., [RefSeq, PubMed]; Fructosamine 3-kinase and fructosamine 3-kinase-related protein have roles in repairing damage caused by ribose 5-phosphate, [RefSeq, PubMed]; Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:16819943). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (By similarity). Involved in intracellular deglycation in erythrocytes and pancreatic islets (PubMed:16819943, PubMed:20009024). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (PubMed:31398338). Also able to phosphorylate psicosamines and ribulosamines (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; These data indicate that FN3K serves as a protein repair enzyme and also in the metabolism of endogenously produced free fructose-epsilon-lysine., [RefSeq, PubMed]; We conclude that, despite its ability to reduce the glycation of intracellular islet proteins, FN3K is neither required for the maintenance of beta-cell survival and function under control conditions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6N6", "ec_number_list": "2.7.1.-;2.7.1.172;2.7.1.171", "go_molecular_function": "GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0102194 protein-fructosamine 3-kinase activity;GO:0102193 protein-ribulosamine 3-kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0030389 fructosamine metabolic process;GO:0030855 epithelial cell differentiation;GO:0036528 peptidyl-lysine deglycation;GO:0036525 protein deglycation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ER35-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI19-1", "uniprot_id": "FIBP_MOUSE", "mass": 41204.0, "length": 357, "protein_name": "Acidic fibroblast growth factor intracellular-binding protein", "gene_name": "Fibp", "organism": "Mouse", "refseq_name": "acidic fibroblast growth factor intracellular-binding protein isoform 2", "refseq_ac": "NP_067413", "gene_names_uniprotkb": "Fibp", "gene_names_refseq": "2010004G08Rik; 2010005N21Rik; 3010027N18Rik; Fibp", "protein_names_uniprotkb": "Acidic fibroblast growth factor intracellular-binding protein; FGF-1 intracellular-binding protein; aFGF intracellular-binding protein", "protein_names_refseq": "FGF-1 intracellular-binding protein; aFGF intracellular binding protein; acidic fibroblast growth factor intracellular-binding protein isoform 2; acidic fibroblast growth factor intracellular-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:58249)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11104667;27183861;34428180", "class_list": "", "function": "May be involved in mitogenic function of FGF1 (By similarity). May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0016607 nuclear speck;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JI19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMF3-1", "uniprot_id": "GBG13_MOUSE", "mass": 7979.0, "length": 67, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13", "gene_name": "Gng13", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13", "refseq_ac": "NP_071867", "gene_names_uniprotkb": "Gng13", "gene_names_refseq": "1500031D04Rik; Ggamma13; Gng13; Hg3j", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13", "protein_names_refseq": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13; heterotrimeric guanine nucleotide-binding protein 3j", "tax_id": 10090, "disease": "", "pathway": " (mmu:64337); (R-MMU-1296041); (R-MMU-202040); (R-MMU-381676); (R-MMU-381753); (R-MMU-381771); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9717207); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 31, "publication_count": 3, "publication_id_list": "10570481;10679242;12454992", "class_list": "", "function": "Ggamma13 subunit is coexpressed in physiologically ON-type cone bipolar cells with Gbeta3 and Gbeta4 but is not present in OFF-type bipolar cells., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JMF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXC1-1", "uniprot_id": "FETUB_MOUSE", "mass": 42713.0, "length": 388, "protein_name": "Fetuin-B", "gene_name": "Fetub", "organism": "Mouse", "refseq_name": "fetuin-B isoform 2", "refseq_ac": "NP_001077373", "gene_names_uniprotkb": "Fetub", "gene_names_refseq": "2310011O17Rik; D17980; Fetub; Gugu", "protein_names_uniprotkb": "Fetuin-B; Fetuin-like protein IRL685", "protein_names_refseq": "IRL685; fetuin-B isoform 2; fetuin-B; fetuin-like protein IRL685", "tax_id": 10090, "disease": "", "pathway": " (mmu:59083)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10947975;15499407;17330941;21750661;23562279;32147518;37883127;39382879;39627609", "class_list": "", "function": "Fetuin-B Interacts With Insulin Receptor-beta and Promotes Insulin Resistance in Retina Cells., [RefSeq, PubMed]; Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-kappaB Signaling Pathway., [RefSeq, PubMed]; Overexpression of Fetuin-B in skin squamous carcinoma cells led to suppression of tumor growth in nude mice., [RefSeq, PubMed]; Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening., [UniProtKB, PubMed]; Upregulated hepatokine fetuin B aggravates myocardial ischemia/reperfusion injury through inhibiting insulin signaling in diabetic mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0007338 single fertilization;GO:0010951 negative regulation of endopeptidase activity", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9QXC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXW4-1", "uniprot_id": "FSCN3_MOUSE", "mass": 56443.0, "length": 498, "protein_name": "Fascin-3", "gene_name": "Fscn3", "organism": "Mouse", "refseq_name": "fascin-3 isoform 1", "refseq_ac": "NP_062515", "gene_names_uniprotkb": "Fscn3", "gene_names_refseq": "Fscn3", "protein_names_uniprotkb": "Fascin-3; Testis fascin", "protein_names_refseq": "fascin (testis); fascin homolog 3, actin-bundling protein, testicular; fascin-3 isoform 1; fascin-3; testis fascin", "tax_id": 10090, "disease": "", "pathway": " (mmu:56223)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11925108;35449315", "class_list": "", "function": "Acts as an actin bundling protein., [UniProtKB]; Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility., [RefSeq, PubMed]; This is a novel, spermatid-specific murine paralog of the actin-binding protein fascin FSCN1. Its expression is restricted to the elongated spermatid head., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80YU6", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0030426 growth cone;GO:0030175 filopodium", "go_biological_process": "GO:0016477 cell migration;GO:0007286 spermatid development;GO:0030036 actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0007163 establishment or maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QXW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZN1-1", "uniprot_id": "FXL17_MOUSE", "mass": 75683.0, "length": 701, "protein_name": "F-box/LRR-repeat protein 17", "gene_name": "Fbxl17", "organism": "Mouse", "refseq_name": "F-box/LRR-repeat protein 17", "refseq_ac": "NP_056609", "gene_names_uniprotkb": "Fbxl17; Fbl17; Fbx13; Fbxo13", "gene_names_refseq": "6330576B01Rik; C130023C01Rik; Fbx13; Fbxl17; Fbxo13", "protein_names_uniprotkb": "F-box/LRR-repeat protein 17; F-box and leucine-rich repeat protein 17; F-box only protein 13", "protein_names_refseq": "F-box only protein 13; F-box/LRR-repeat protein 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:50758); (R-MMU-9708530)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10531037;21750661;27234298;28883095;31219806;34428180", "class_list": "", "function": "Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome (By similarity). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (By similarity). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (PubMed:28883095)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRC1;Q8BTC3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0007399 nervous system development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0014033 neural crest cell differentiation;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QZN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0N0-1", "uniprot_id": "GALK1_MOUSE", "mass": 42295.0, "length": 392, "protein_name": "Galactokinase", "gene_name": "Galk1", "organism": "Mouse", "refseq_name": "galactokinase", "refseq_ac": "NP_058601", "gene_names_uniprotkb": "Galk1; Galk; Glk", "gene_names_refseq": "GALK; Galk1; Gk; Glk1; Glk", "protein_names_uniprotkb": "Galactokinase; 2.7.1.6; Galactose kinase", "protein_names_refseq": "galactokinase; galactose kinase", "tax_id": 10090, "disease": "galactokinase deficiency (Disease Ontology:DOID:14695); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:14635); (R-MMU-70370)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10915771;20173027;25428506;25428507;30059200;30084848;30779550;31219806;34428180;39627609", "class_list": "glycogene", "function": "Catalyzes the transfer of a phosphate from ATP to alpha-D-galactose and participates in the first committed step in the catabolism of galactose., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 22, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIA6", "ec_number_list": "2.7.1.6", "go_molecular_function": "GO:0005524 ATP binding;GO:0004335 galactokinase activity;GO:0005534 galactose binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0019402 galactitol metabolic process;GO:0061623 glycolytic process from galactose;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway;GO:0006012 galactose metabolic process;GO:0046835 carbohydrate phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9R0N0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WV91-1", "uniprot_id": "FPRP_MOUSE", "mass": 98722.0, "length": 879, "protein_name": "Prostaglandin F2 receptor negative regulator", "gene_name": "Ptgfrn", "organism": "Mouse", "refseq_name": "prostaglandin F2 receptor negative regulator precursor", "refseq_ac": "NP_035327", "gene_names_uniprotkb": "Ptgfrn; Fprp", "gene_names_refseq": "4833445A08Rik; CD9P-1; EWI-F; FPRP; Ptgfrn; Trim45", "protein_names_uniprotkb": "Prostaglandin F2 receptor negative regulator; CD9 partner 1; CD9P-1; EWI-F; Glu-Trp-Ile EWI motif-containing protein F; Prostaglandin F2-alpha receptor regulatory protein; Prostaglandin F2-alpha receptor-associated protein", "protein_names_refseq": "CD9 partner 1; glu-Trp-Ile EWI motif-containing protein F; prostaglandin F2 receptor negative regulator precursor; prostaglandin F2-alpha receptor regulatory protein; prostaglandin F2-alpha receptor-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:19221)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10893677;19349973;19656770;20485683;23575678;30084848;30899004;31219806;33300544", "class_list": "", "function": "Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q5SRA8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0034389 lipid droplet organization;GO:0014905 myoblast fusion involved in skeletal muscle regeneration", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9WV91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U431-1", "uniprot_id": "GPR39_MOUSE", "mass": 51589.0, "length": 456, "protein_name": "G protein-coupled receptor 39", "gene_name": "Gpr39", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gpr39", "gene_names_refseq": "", "protein_names_uniprotkb": "G protein-coupled receptor 39", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:71111); (R-MMU-373076); (R-MMU-416476); (R-MMU-418555)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "12679517;16959833;17030183;18180304;21750661;21784784;25605945;31346193;34203471;34428180;36087899", "class_list": "", "function": "Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed:17030183, PubMed:18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (By similarity). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (PubMed:31346193). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (PubMed:21784784). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner. Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80UC7", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0035483 gastric emptying;GO:0060455 negative regulation of gastric acid secretion;GO:0032024 positive regulation of insulin secretion;GO:0042391 regulation of membrane potential;GO:0019216 regulation of lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q5U431-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PCP7-1", "uniprot_id": "GP156_MOUSE", "mass": 87040.0, "length": 798, "protein_name": "Probable G protein-coupled receptor 156", "gene_name": "Gpr156", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 156", "refseq_ac": "NP_700443", "gene_names_uniprotkb": "Gpr156; Gababl", "gene_names_refseq": "Gababl; Gpr156", "protein_names_uniprotkb": "Probable G protein-coupled receptor 156; GABAB-related G protein-coupled receptor", "protein_names_refseq": "GABAB-related G-protein coupled receptor; probable G-protein coupled receptor 156", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565)", "pathway": " (mmu:239845)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12591167;21750661;25428506;34001891;36928819", "class_list": "", "function": "EMX2-GPR156-Galphai reverses hair cell orientation in mechanosensory epithelia. Publication Status: Online-Only, [RefSeq, PubMed]; Orphan G protein-coupled receptor involved in the regulation of hair cell orientation in mechanosensory organs of the inner ear. It is required to trigger a 180 degree reversal in hair cell orientation, creating a virtual line of polarity reversal (LPR) across which stereociliary bundles are arranged in opposite orientations., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K452", "ec_number_list": "", "go_molecular_function": "GO:0004965 G protein-coupled GABA receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0038039 G protein-coupled receptor heterodimeric complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0160194 stereocilium bundle organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PCP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24472-1", "uniprot_id": "GSTA4_MOUSE", "mass": 25564.0, "length": 222, "protein_name": "Glutathione S-transferase A4", "gene_name": "Gsta4", "organism": "Mouse", "refseq_name": "glutathione S-transferase A4", "refseq_ac": "NP_034487", "gene_names_uniprotkb": "Gsta4; Gsta", "gene_names_refseq": "GST5.7; Gsta4; mGsta4", "protein_names_uniprotkb": "Glutathione S-transferase A4; 2.5.1.18; GST 5.7; GST A4-4; GST class-alpha member 4; GSTA4-4; Glutathione S-transferase 5.7", "protein_names_refseq": "GST A4-4; GST class-alpha member 4; GSTA4-4; glutathione S-transferase 5.7; glutathione S-transferase A4", "tax_id": 10090, "disease": "", "pathway": " (mmu:14860)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10508391;12646569;1426286;1898365;21750661;34428180;36288343;37507081;38573593;9498801", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB, PubMed]; Glutathione S-Transferase alpha4 Alleviates Hyperlipidemia-Induced Vascular Neointimal Hyperplasia in Arteriovenous Grafts via Inhibiting Endoplasmic Reticulum Stress. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQ81;Q9CTY7;Q9CY87;Q9D038", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0015643 toxic substance binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0061771 response to caloric restriction;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P24472-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFR4-1", "uniprot_id": "GNS_MOUSE", "mass": 61175.0, "length": 544, "protein_name": "N-acetylglucosamine-6-sulfatase", "gene_name": "Gns", "organism": "Mouse", "refseq_name": "N-acetylglucosamine-6-sulfatase isoform 1 precursor", "refseq_ac": "NP_083640", "gene_names_uniprotkb": "Gns", "gene_names_refseq": "2610016K11Rik; G6S; Gns", "protein_names_uniprotkb": "N-acetylglucosamine-6-sulfatase; 3.1.6.14; G6S; Glucosamine-6-sulfatase", "protein_names_refseq": "N-acetylglucosamine-6-sulfatase isoform 1 precursor; N-acetylglucosamine-6-sulfatase", "tax_id": 10090, "disease": "mucopolysaccharidosis type IIID (Disease Ontology:DOID:0111402); mucopolysaccharidosis III (Disease Ontology:DOID:12801)", "pathway": " (mmu:75612); (R-MMU-2022857); (R-MMU-432720); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;18250455;21750661;28334745;29187734;30059200;30899004;35984892;37828378", "class_list": "glycogene", "function": "Hydrolyzes 6-sulfate groups in N-acetyl-d-glucosaminide units of heparin sulfate and keratan sulfate., [UniProtKB, UniProtKB]; Mice deficient in GNS showed lysosomal storage pathology and a phenotype that closely resembled human MPSIIID. Moreover, treatment of the GNS-deficient animals with GNS-encoding adeno-associated viral (AAV) vectors of serotype 9 delivered to the cerebrospinal fluid completely corrected pathological storage, improved lysosomal functionality in the CNS and somatic tissues, resolved neuroinflammation, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 2, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWT0;Q8BJJ7;Q8BK91", "ec_number_list": "4.6.1.19;2.4.1.25;3.2.1.33;1.11.1.27;3.1.1.4;2.3.1.23;3.5.4.6;1.11.1.24;3.2.1.24;4.6.1.18;3.4.22.52;3.4.19.12;2.3.1.-;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;3.2.1.17;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;1.11.2.2;3.2.1.31;2.7.1.11;3.4.16.5;3.4.16.-;5.2.1.8;3.4.23.5;2.5.1.18;3.2.1.52;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;3.4.21.20;2.7.10.2;2.7.11.13;5.3.2.1;5.3.3.12;3.6.5.5;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;2.7.11.1;2.7.1.40;3.5.4.5;3.1.22.1;3.4.25.1;3.6.5.2;3.1.27.-;3.4.14.1;2.7.4.6;2.7.13.3;3.6.4.6;3.5.3.15;2.7.1.1;2.7.1.-;3.4.21.37;3.1.6.4;3.4.21.76;3.5.3.1;3.1.1.47;3.6.4.13;1.6.5.5;3.5.1.26;2.7.11.22;2.7.11.23;2.3.2.26;5.4.2.2;5.4.2.7;3.1.3.-;2.3.2.27;3.1.6.14;3.1.3.16;5.3.99.3;6.3.4.21;2.4.1.1;3.4.19.1;3.6.1.6;2.3.3.8;1.8.4.-;5.3.4.1;4.1.2.4;3.2.1.51;2.3.2.5;5.4.2.11;5.4.2.4;1.6.2.2;3.4.14.2;2.4.1.186;3.4.21.4;3.4.18.1;3.5.1.23;3.5.1.-;3.4.19.9", "go_molecular_function": "GO:0008449 N-acetylglucosamine-6-sulfatase activity;GO:0046872 metal ion binding;GO:0008484 sulfuric ester hydrolase activity;GO:0043199 sulfate binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005764 lysosome;GO:0042582 azurophil granule", "go_biological_process": "GO:0030203 glycosaminoglycan metabolic process;GO:0042340 keratan sulfate proteoglycan catabolic process;GO:0030200 heparan sulfate proteoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q8BFR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYE6-1", "uniprot_id": "GOGA5_MOUSE", "mass": 82368.0, "length": 729, "protein_name": "Golgin subfamily A member 5", "gene_name": "Golga5", "organism": "Mouse", "refseq_name": "golgin subfamily A member 5", "refseq_ac": "NP_001185933", "gene_names_uniprotkb": "Golga5; Retii", "gene_names_refseq": "Golga5; Ret-II", "protein_names_uniprotkb": "Golgin subfamily A member 5; Golgin-84; Protein Ret-II; Protein Sumiko", "protein_names_refseq": "golgi autoantigen golgin subfamily a5; golgi autoantigen, golgin subfamily a, 5; golgin subfamily A member 5; golgin-84; protein Sumiko", "tax_id": 10090, "disease": "", "pathway": " (mmu:27277)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "17242355;21183079;21750661;22645316;24368089;25428506;26495903;26740625;28509431;30084848;31219806;32848054;36852467;40021952;40885482", "class_list": "", "function": "Golga5 is not required for mouse embryonic development, postnatal survival, or fertility., [RefSeq, PubMed]; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Its deficit is associated with Golgi fragmentation that induces tau hyperphosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O88317;Q3TGE7;Q3U6S5;Q3UUF9", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005797 Golgi medial cisterna;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0007030 Golgi organization;GO:0048193 Golgi vesicle transport;GO:0000301 retrograde transport, vesicle recycling within Golgi", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9QYE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13562-1", "uniprot_id": "GON1_MOUSE", "mass": 10337.0, "length": 90, "protein_name": "Progonadoliberin-1", "gene_name": "Gnrh1", "organism": "Mouse", "refseq_name": "progonadoliberin-1 isoform 1 preproprotein", "refseq_ac": "NP_032171", "gene_names_uniprotkb": "Gnrh1; Gnrh", "gene_names_refseq": "Gnrh1; Gnrh2; Gnrh; LHRH; Lhrh1; Lnrh; hpg", "protein_names_uniprotkb": "Progonadoliberin-1; GnRH-I; Gonadoliberin I; Gonadotropin-releasing hormone I; LH-RH I; Luliberin I; Luteinizing hormone-releasing hormone I; Progonadoliberin I; Prolactin release-inhibiting factor I", "protein_names_refseq": "gonadotropin releasing hormone 2; luteinizing hormone-releasing hormone I; progonadoliberin I; progonadoliberin-1 isoform 1 preproprotein", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 12 with or without anosmia (Disease Ontology:DOID:0090072); prostatic hypertrophy (Disease Ontology:DOID:11132); breast cancer (Disease Ontology:DOID:1612); periodontitis (Disease Ontology:DOID:824)", "pathway": " (mmu:14714); (R-MMU-375281); (R-MMU-416476)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15489266;21750661;3024317;37189369", "class_list": "", "function": "Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones., [UniProtKB]; This gene encodes hypophysiotropic peptides belonging to the family of gonadotropin-releasing hormones that stimulate the release of gonadotropins and suppress secretion of prolactin from the pituitary gland. The encoded protein is proteolytically processed to generate two biologically active mature peptides. A deletional mutation encompassing the distal half of this gene in mice resulting in the loss of the encoded protein leads to hypogonadism and infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005183 gonadotropin hormone-releasing hormone activity;GO:0031530 gonadotropin-releasing hormone receptor binding", "go_cellular_component": "GO:1990008 neurosecretory vesicle;GO:0005615 extracellular space;GO:0005798 Golgi-associated vesicle;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:1990637 response to prolactin;GO:0033087 negative regulation of immature T cell proliferation;GO:2000354 regulation of ovarian follicle development;GO:0032496 response to lipopolysaccharide;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P13562-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VC9-1", "uniprot_id": "GHITM_MOUSE", "mass": 37275.0, "length": 346, "protein_name": "Growth hormone-inducible transmembrane protein", "gene_name": "Ghitm", "organism": "Mouse", "refseq_name": "growth hormone-inducible transmembrane protein", "refseq_ac": "NP_001186051", "gene_names_uniprotkb": "Ghitm; Mics1", "gene_names_refseq": "1010001P14Rik; Ghitm; MICS1; PTD010; Tmbim5", "protein_names_uniprotkb": "Growth hormone-inducible transmembrane protein; MICS1; Mitochondrial morphology and cristae structure 1", "protein_names_refseq": "growth hormone-inducible transmembrane protein; mitochondrial morphology and cristae structure 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66092)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11416014;21750661;26740625;31219806;34203471;34428180;35715207", "class_list": "", "function": "Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:35715207). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Also functions as an electroneutral mitochondrial proton/potassium exchanger (PubMed:35715207). Required for the mitochondrial tubular network and cristae organization (PubMed:35715207). Involved in apoptotic release of cytochrome c (By similarity). Inhibits AFG3L2 proteolytic activity, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (By similarity). However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGB7;Q3UA74;Q8N9T5", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015369 calcium:proton antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0006915 apoptotic process;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0090201 negative regulation of release of cytochrome c from mitochondria;GO:0099093 calcium export from the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91VC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AS29-1", "uniprot_id": "GRIK3_MOUSE", "mass": 104051.0, "length": 919, "protein_name": "Glutamate receptor ionotropic, kainate 3", "gene_name": "Grik3", "organism": "Mouse", "refseq_name": "glutamate receptor ionotropic, kainate 3 precursor", "refseq_ac": "NP_001074566", "gene_names_uniprotkb": "Grik3; Glur7", "gene_names_refseq": "9630027E11; GluK3; GluR7-3; Glur-7; Glur7; Grik3", "protein_names_uniprotkb": "Glutamate receptor ionotropic, kainate 3; GluK3; GluR-7; GluR7; Glutamate receptor 7", "protein_names_refseq": "glutamate receptor 7; glutamate receptor ionotropic, kainate 3 precursor", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:14807); (R-MMU-451308); (R-MMU-500657)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11124978;17620617;20007474;22645316;30899004;32567721;33300544;38402313", "class_list": "", "function": "Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety. Publication Status: Online-Only, [RefSeq, PubMed]; Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Transcript variants encoding different isoforms have been described for this gene, however, their full-length nature is not known. [provided by RefSeq, Jul 2008]., [RefSeq]; Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:17620617, PubMed:20007474). In association with GRIK2, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (PubMed:17620617)., [UniProtKB, PubMed, PubMed]; Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 2, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q17R20;Q9JIA8", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0042802 identical protein binding;GO:0004970 glutamate-gated receptor activity;GO:0015277 kainate selective glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043195 terminal bouton", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0035249 synaptic transmission, glutamatergic;GO:0051967 negative regulation of synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission;GO:0007216 G protein-coupled glutamate receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "B1AS29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RSH2-1", "uniprot_id": "GNAI1_MOUSE", "mass": 40361.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-1", "gene_name": "Gnai1", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(i) subunit alpha-1", "refseq_ac": "NP_034435", "gene_names_uniprotkb": "Gnai1; Gnai-1", "gene_names_refseq": "Gialpha1; Gnai-1; Gnai1; Hg1b", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(i) subunit alpha-1; 3.6.5.-; Adenylate cyclase-inhibiting G alpha protein", "protein_names_refseq": "adenylate cyclase-inhibiting G alpha protein; guanine nucleotide binding protein (G protein), alpha inhibiting 1; guanine nucleotide binding protein, alpha inhibiting 1; guanine nucleotide-binding protein G(i) subunit alpha-1; heterotrimeric guanine nucleotide-binding protein 1b", "tax_id": 10090, "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (mmu:14677); (R-MMU-170670); (R-MMU-392170); (R-MMU-400042); (R-MMU-418594); (R-MMU-9009391)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "22645316;31219806;37507081", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis. Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;4.6.1.1;2.7.10.2;3.6.5.4;3.6.5.5;2.7.7.85;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0031821 G protein-coupled serotonin receptor binding;GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1903998 regulation of eating behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0051301 cell division;GO:0070098 chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B2RSH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922P9-1", "uniprot_id": "GLYR1_MOUSE", "mass": 59716.0, "length": 546, "protein_name": "Cytokine-like nuclear factor N-PAC", "gene_name": "Glyr1", "organism": "Mouse", "refseq_name": "cytokine-like nuclear factor N-PAC isoform 2", "refseq_ac": "NP_082996", "gene_names_uniprotkb": "Glyr1; Np60", "gene_names_refseq": "2810419J22Rik; 3930401K13Rik; Glyr1; NDF; Npac", "protein_names_uniprotkb": "Cytokine-like nuclear factor N-PAC; Glyoxylate reductase 1 homolog; NPAC; Nuclear protein NP60; Putative oxidoreductase GLYR1", "protein_names_refseq": "cytokine-like nuclear factor N-PAC isoform 2; cytokine-like nuclear factor n-pac; nuclear protein NP60; putative oxidoreductase GLYR1", "tax_id": 10090, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651)", "pathway": " (mmu:74022)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16452087;21750661;25605945;29187734;29759984;31219806;33676077;34428180;35182466;35820727;37828378;38395189", "class_list": "", "function": "Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:29759984). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA. Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (By similarity). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Deficiency of nucleosome-destabilizing factor GLYR1 dampens spermatogenesis in mice., [RefSeq, PubMed]; Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells., [RefSeq, PubMed]; Transcription factor protein interactomes reveal genetic determinants in heart disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TX02;Q9CYQ1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0051287 NAD binding;GO:0042393 histone binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0140673 transcription elongation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q922P9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDL9-1", "uniprot_id": "GLIS2_MOUSE", "mass": 55842.0, "length": 521, "protein_name": "Zinc finger protein GLIS2", "gene_name": "Glis2", "organism": "Mouse", "refseq_name": "zinc finger protein GLIS2", "refseq_ac": "NP_112461", "gene_names_uniprotkb": "Glis2; Gli5; Nkl", "gene_names_refseq": "Gli5; Glis2; Klf16; Nkl", "protein_names_uniprotkb": "Zinc finger protein GLIS2; GLI-similar 2; Neuronal Krueppel-like protein; Zinc finger protein GLI5", "protein_names_refseq": "GLI-Kruppel family member GLI5; GLI-similar 2; Kruppel-like factor 16 (neuronal); neuronal Krueppel-like protein; zinc finger protein GLI5; zinc finger protein GLIS2", "tax_id": 10090, "disease": "nephronophthisis 7 (Disease Ontology:DOID:0111116)", "pathway": " (mmu:83396)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11262234;11741991;16326862;17289029;17344476;21750661;21816948;35435331;36397300;38506068;38693102", "class_list": "", "function": "Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Characterization of Glis2, a novel gene encoding a Gli-related, Kruppel-like transcription factor with transactivation and repressor functions, [RefSeq, PubMed]; GLIS2 Prevents Hepatic Fibrosis by Competitively Binding HDAC3 to Inhibit Hepatic Stellate Cell Activation., [RefSeq, PubMed]; Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance. Erratum:[Adv Sci (Weinh). 2026 Mar;13(18):e74330. doi: 10.1002/advs.74330. PMID: 41677345], [RefSeq, PubMed]; Long noncoding RNA Glis2 regulates podocyte mitochondrial dysfunction and apoptosis in diabetic nephropathy via sponging miR-328-5p., [RefSeq, PubMed]; Positive regulator of neuronal differentiation, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R4X9;Q99MY6;Q99P73", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0061005 cell differentiation involved in kidney development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VDL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JL62-1", "uniprot_id": "GLTP_MOUSE", "mass": 23690.0, "length": 209, "protein_name": "Glycolipid transfer protein", "gene_name": "Gltp", "organism": "Mouse", "refseq_name": "glycolipid transfer protein", "refseq_ac": "NP_062795", "gene_names_uniprotkb": "Gltp", "gene_names_refseq": "1110001F24Rik; Gltp", "protein_names_uniprotkb": "Glycolipid transfer protein; GLTP", "protein_names_refseq": "glycolipid transfer protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56356); (R-MMU-9845576)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180;37507081", "class_list": "glycogene", "function": "Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91YJ7;Q9CTK9", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:1902387 ceramide 1-phosphate binding;GO:1902388 ceramide 1-phosphate transfer activity;GO:0017089 glycolipid transfer activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0035627 ceramide transport;GO:0035902 response to immobilization stress;GO:0120009 intermembrane lipid transfer;GO:0046317 regulation of glucosylceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JL62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4M9-1", "uniprot_id": "GLTL5_MOUSE", "mass": 49874.0, "length": 431, "protein_name": "Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5", "gene_name": "Galntl5", "organism": "Mouse", "refseq_name": "inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5", "refseq_ac": "NP_080725", "gene_names_uniprotkb": "Galntl5; Galnt15", "gene_names_refseq": "1700021B12Rik; Galnt15; Galntl5", "protein_names_uniprotkb": "Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; GalNAc-T15; Polypeptide GalNAc transferase 15; Protein-UDP acetylgalactosaminyltransferase 15; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15; pp-GaNTase 15", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15; galNAc-T15; inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; polypeptide GalNAc transferase 15; polypeptide N-acetylgalactosaminyltransferase-like 5; pp-GaNTase 15; protein-UDP acetylgalactosaminyltransferase 15; putative polypeptide N-acetylgalactosaminyltransferase-like protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:67909); (R-MMU-913709)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20173027;21750661;24398516", "class_list": "glycogene;glycosyltransferase", "function": "Mutated GALNTL5 has a role in male infertility with impairment of sperm motility, [RefSeq, PubMed]; Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A6H655;Q810S4;Q9CW06", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031902 late endosome membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0007286 spermatid development", "synthesized_glycan_count": 7434, "hit_score": 0.4, "record_id": "Q9D4M9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10648-1", "uniprot_id": "GSTA2_MOUSE", "mass": 25542.0, "length": 222, "protein_name": "Glutathione S-transferase A2", "gene_name": "Gsta2", "organism": "Mouse", "refseq_name": "glutathione S-transferase A2", "refseq_ac": "NP_032208", "gene_names_uniprotkb": "Gsta2", "gene_names_refseq": "Gst2-2; Gsta2; Gstc-2; Gstc2", "protein_names_uniprotkb": "Glutathione S-transferase A2; 2.5.1.18; GST class-alpha member 2; Glutathione S-transferase GT41A", "protein_names_refseq": "GST class-alpha member 2; glutathione S-transferase A2; glutathione S-transferase GT41A", "tax_id": 10090, "disease": "ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:14858); (R-MMU-156590); (R-MMU-9748787)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12549910;21750661;30084848;3417659;9606968", "class_list": "", "function": "Catalyzes the conjugation of glutathione to a large variety of electrophilic compounds., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8Q1", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0005504 fatty acid binding;GO:0042803 protein homodimerization activity;GO:0004769 steroid Delta-isomerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0009617 response to bacterium;GO:0006805 xenobiotic metabolic process;GO:0035634 response to stilbenoid;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P10648-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35205-1", "uniprot_id": "GRAK_MOUSE", "mass": 29251.0, "length": 263, "protein_name": "Granzyme K", "gene_name": "Gzmk", "organism": "Mouse", "refseq_name": "granzyme K precursor", "refseq_ac": "NP_032222", "gene_names_uniprotkb": "Gzmk", "gene_names_refseq": "Gzmk", "protein_names_uniprotkb": "Granzyme K; 3.4.21.-", "protein_names_refseq": "granzyme K precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14945)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17308307;21750661;28428612;33271118;33300544;34815792;36652225;39814882;39914456;9242702", "class_list": "", "function": "Biological relevance of Granzymes A and K during E. coli sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; Granzyme K contributes to endothelial microvascular damage and leakage during skin inflammation., [RefSeq, PubMed]; GzmK-induced caspase-independent death occurs through Bid-dependent mitochondrial damage that is different from GzmA, [RefSeq, PubMed]; Serine protease that initiates the GZMK pathway of the complement system, a cascade of proteins directly activated by CD8(+) T-cells that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:39914456). GZMK is specifically secreted by CD8(+) T-cells and mediates both recognition and initiation steps of GZMK complement pathway (By similarity). First acts as a pattern recognition receptor, which specifically recognizes and binds heparan sulfate glycosaminoglycans on the pathogen surface to drive opsonization (By similarity). It then initiates the complement pathway cascade by catalyzing cleavage and activation of C2 and C4, the next components of the complement pathway (By similarity). GZMK-mediated complement activation is an important contributor to tissue inflammation (PubMed:33271118, PubMed:39814882, PubMed:39914456). Also able to cleave and activate F2R/PAR1 and PAR2/F2RL1, possibly promoting interleukin release (By similarity). May also regulate apoptosis by catalyzing cleavage and activation of BID, thereby promoting cytochrome C release from mitochrondria (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005539 glycosaminoglycan binding;GO:0038187 pattern recognition receptor activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0006954 inflammatory response;GO:0050729 positive regulation of inflammatory response;GO:0090200 positive regulation of release of cytochrome c from mitochondria;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O35205-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4H2-1", "uniprot_id": "GCC1_MOUSE", "mass": 87678.0, "length": 778, "protein_name": "GRIP and coiled-coil domain-containing protein 1", "gene_name": "Gcc1", "organism": "Mouse", "refseq_name": "GRIP and coiled-coil domain-containing protein 1", "refseq_ac": "NP_083176", "gene_names_uniprotkb": "Gcc1", "gene_names_refseq": "4932417P04Rik; Gcc1", "protein_names_uniprotkb": "GRIP and coiled-coil domain-containing protein 1; Golgi coiled-coil protein 1", "protein_names_refseq": "GRIP and coiled-coil domain-containing protein 1; Golgi coiled coil protein 1; golgi coiled-coil protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74375); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;25428506;26495903;30084848;30779550;31219806;34428180", "class_list": "", "function": "Probably involved in maintaining Golgi structure., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCR3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D4H2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCZ1-1", "uniprot_id": "GMPR1_MOUSE", "mass": 37482.0, "length": 345, "protein_name": "GMP reductase 1", "gene_name": "Gmpr", "organism": "Mouse", "refseq_name": "GMP reductase 1", "refseq_ac": "NP_079784", "gene_names_uniprotkb": "Gmpr; Gmpr1", "gene_names_refseq": "2310004P21Rik; GMPR 1; Gmpr", "protein_names_uniprotkb": "GMP reductase 1; 1.7.1.7; GMPR 1; Guanosine 5'-monophosphate oxidoreductase 1; Guanosine monophosphate reductase 1", "protein_names_refseq": "GMP reductase 1; guanosine 5'-monophosphate oxidoreductase 1; guanosine monophosphate reductase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66355); (R-MMU-74217)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21183079;21750661;31219806;34428180;37507081;39927985", "class_list": "", "function": "A similar gene in human encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. [provided by RefSeq, May 2015]., [RefSeq]; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.7.1.7", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003920 GMP reductase activity", "go_cellular_component": "GO:1902560 GMP reductase complex", "go_biological_process": "GO:0032264 IMP salvage;GO:0006144 purine nucleobase metabolic process;GO:0009117 nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DCZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3W4-1", "uniprot_id": "GPN3_MOUSE", "mass": 32790.0, "length": 284, "protein_name": "GPN-loop GTPase 3", "gene_name": "Gpn3", "organism": "Mouse", "refseq_name": "GPN-loop GTPase 3", "refseq_ac": "NP_077178", "gene_names_uniprotkb": "Gpn3; Atpbd1c; D5Ertd708e", "gene_names_refseq": "A930018B01Rik; Atpbd1c; D5Ertd708e; Gpn3", "protein_names_uniprotkb": "GPN-loop GTPase 3; 3.6.5.-; ATP-binding domain 1 family member C", "protein_names_refseq": "ATP-binding domain 1 family member C; GPN-loop GTPase 3; protein x 0004", "tax_id": 10090, "disease": "", "pathway": " (mmu:68080)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25605945", "class_list": "", "function": "Small GTPase involved in the correct assembly of RNA polymerase II (RNAPII) complex, ensuring proper nuclear import of RNAPII., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Small GTPase involved in the correct assembly of RNA polymerase II complex, ensuring their proper nuclear import of RNAPII., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BU32", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D3W4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q56A08-1", "uniprot_id": "GPKOW_MOUSE", "mass": 53832.0, "length": 488, "protein_name": "G-patch domain and KOW motifs-containing protein", "gene_name": "Gpkow", "organism": "Mouse", "refseq_name": "G-patch domain and KOW motifs-containing protein", "refseq_ac": "NP_776108", "gene_names_uniprotkb": "Gpkow", "gene_names_refseq": "4432411B18; DXErtd697e; DXImx41e; Gpkow; T54", "protein_names_uniprotkb": "G-patch domain and KOW motifs-containing protein; Protein MOS2 homolog", "protein_names_refseq": "G-patch domain and KOW motifs-containing protein; g patch domain and KOW motifs-containing protein; protein MOS2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:209416); (R-MMU-72163)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16271871;21183079;21750661;30084848;30779550;31219806;34428180;36210013", "class_list": "", "function": "RNA-binding protein involved in pre-mRNA splicing., [UniProtKB, UniProtKB]; RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JLW7;A2AEU7;Q6P5V0;Q8C1C3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071018 U12-type catalytic step 2 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q56A08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q78HU7-1", "uniprot_id": "GLPC_MOUSE", "mass": 10329.0, "length": 95, "protein_name": "Glycophorin-C", "gene_name": "Gypc", "organism": "Mouse", "refseq_name": "glycophorin-C isoform 1", "refseq_ac": "NP_001041672", "gene_names_uniprotkb": "Gypc", "gene_names_refseq": "0610037F22Rik; Cd236r; Gypc", "protein_names_uniprotkb": "Glycophorin-C", "protein_names_refseq": "Gerbich antigen; glycophorin-C isoform 1", "tax_id": 10090, "disease": "malaria (Disease Ontology:DOID:12365)", "pathway": " (mmu:71683)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;26495903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6XFR5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030863 cortical cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q78HU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F8VQN3-1", "uniprot_id": "GPR31_MOUSE", "mass": 35642.0, "length": 319, "protein_name": "12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor", "gene_name": "Gpr31", "organism": "Mouse", "refseq_name": "12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor", "refseq_ac": "NP_001013854", "gene_names_uniprotkb": "Gpr31; Gpr31b; Gpr31c", "gene_names_refseq": "12-HETER; GPR31c(t); Gpr31b; Gpr31c; Gpr31", "protein_names_uniprotkb": "12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; 12-(S)-HETE receptor; 12-HETER; G protein-coupled receptor 31", "protein_names_refseq": "12-(S)-HETE receptor; 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; G-protein coupled receptor 31", "tax_id": 10090, "disease": "", "pathway": " (mmu:436440); (R-MMU-418594); (R-MMU-444209)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10501965;29227475;30084848;30675063;30779550", "class_list": "", "function": "High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers (By similarity) (PubMed:29227475). 12-S-HETE is a eicosanoid, a 12-lipoxygenase (ALOX12) metabolite of arachidonic acid, involved in many physiologic and pathologic processes, such as cell growth, adhesion, inflammation and cancer promotion. 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways and leads to cell growth. Plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM (By similarity). Contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1(+) phagocytes for the uptake of luminal antigens (PubMed:30675063). Also acts as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury (PubMed:29227475)., [UniProtKB, PubMed, PubMed, UniProtKB]; Proton-sensing G protein-coupled receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLS1", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0050544 arachidonate binding;GO:0045125 bioactive lipid receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002931 response to ischemia;GO:0007186 G protein-coupled receptor signaling pathway;GO:0050728 negative regulation of inflammatory response;GO:0010447 response to acidic pH;GO:0050778 positive regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F8VQN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWG1-1", "uniprot_id": "GLIP1_MOUSE", "mass": 29129.0, "length": 255, "protein_name": "Glioma pathogenesis-related protein 1", "gene_name": "Glipr1", "organism": "Mouse", "refseq_name": "glioma pathogenesis-related protein 1 precursor", "refseq_ac": "NP_082884", "gene_names_uniprotkb": "Glipr1", "gene_names_refseq": "2410114O14Rik; Glipr1; RTVP-1; RTVP1; gliPR 1; mRTVP-1", "protein_names_uniprotkb": "Glioma pathogenesis-related protein 1; GliPR 1", "protein_names_refseq": "GLI pathogenesis-related 1 (glioma); glioma pathogenesis-related protein 1 precursor; glioma pathogenesis-related protein 1; related to testes-specific, vespid, and pathogenesis proteins", "tax_id": 10090, "disease": "", "pathway": " (mmu:73690); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11971968;20433698;21750661;26988096;31672133;31995627;34675506", "class_list": "", "function": "Collectively, this study characterizes multimeric protein complexes on the sperm surface and identifies GLIPRL1L1 as a physiologically relevant regulator of IZUMO1 function and the fertilization process. Publication Status: Online-Only, [RefSeq, PubMed]; GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation via PLAU/EGFR Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of a novel mouse gene, mRTVP-1, as a p53 target gene. The mRTVP-1 protein has 255 amino acids and differs from the human RTVP-1 protein by two short in-frame deletions of two and nine amino acids. (mRTVP-1), [RefSeq, PubMed]; Results find that Glipr1 expression is lost in the 5TGM1 murine multiple myeloma (MM) cell line. Its overexpression in a HMCL/5TGM1 cells did not significantly alter tumor cell growth in vitro or in vivo. These results suggest that GLIPR1 is unlikely to be a potent tumor suppressor in multiple myeloma. Publication Status: Online-Only, [RefSeq, PubMed]; The genetic variation is a key determining factor for the alternative splicing events in the Gli1 5' UTRs, which have functional implications on translational efficiency. Publication Status: Online-Only, [RefSeq, PubMed]; This study reveals a novel pathway that PRMT5/WDR77 regulates GLIPR1 expression to control lung cancer cell growth. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CWG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q50H32-1", "uniprot_id": "GRCR1_MOUSE", "mass": 32402.0, "length": 290, "protein_name": "Glutaredoxin domain-containing cysteine-rich protein 1", "gene_name": "Grxcr1", "organism": "Mouse", "refseq_name": "glutaredoxin domain-containing cysteine-rich protein 1", "refseq_ac": "NP_001018019", "gene_names_uniprotkb": "Grxcr1; pi", "gene_names_refseq": "Grxcr1; Tg(Eno2-Gabrb3)0370Brll; pi; tde", "protein_names_uniprotkb": "Glutaredoxin domain-containing cysteine-rich protein 1", "protein_names_refseq": "glutaredoxin cysteine-rich 1 protein; glutaredoxin domain-containing cysteine-rich protein 1", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 25 (Disease Ontology:DOID:0110483)", "pathway": " (mmu:433899)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11276175;20137774;21750661", "class_list": "", "function": "May play a role in actin filament architecture in developing stereocilia of sensory cells., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005902 microvillus;GO:0060091 kinocilium;GO:0032420 stereocilium", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0060118 vestibular receptor cell development;GO:0007009 plasma membrane organization;GO:0051592 response to calcium ion;GO:1905144 response to acetylcholine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q50H32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0R6-1", "uniprot_id": "GLTD2_MOUSE", "mass": 34453.0, "length": 321, "protein_name": "Glycolipid transfer protein domain-containing protein 2", "gene_name": "Gltpd2", "organism": "Mouse", "refseq_name": "glycolipid transfer protein domain-containing protein 2", "refseq_ac": "NP_666132", "gene_names_uniprotkb": "Gltpd2", "gene_names_refseq": "C730027E14Rik; Gltpd2", "protein_names_uniprotkb": "Glycolipid transfer protein domain-containing protein 2", "protein_names_refseq": "glycolipid transfer protein domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:216871)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1902387 ceramide 1-phosphate binding;GO:1902388 ceramide 1-phosphate transfer activity;GO:0120013 lipid transfer activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0035627 ceramide transport;GO:0032691 negative regulation of interleukin-1 beta production;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K0R6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0C9-1", "uniprot_id": "GMDS_MOUSE", "mass": 41985.0, "length": 372, "protein_name": "GDP-mannose 4,6 dehydratase", "gene_name": "Gmds", "organism": "Mouse", "refseq_name": "GDP-mannose 4,6 dehydratase", "refseq_ac": "NP_666153", "gene_names_uniprotkb": "Gmds", "gene_names_refseq": "Gmds", "protein_names_uniprotkb": "GDP-mannose 4,6 dehydratase; 4.2.1.47; GDP-D-mannose dehydratase; GMD", "protein_names_refseq": "GDP-D-mannose dehydratase; GDP-mannose 4,6 dehydratase; GMD", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIc (Disease Ontology:DOID:0070255); open-angle glaucoma (Disease Ontology:DOID:1067)", "pathway": " (mmu:218138); (R-MMU-6787639)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;26740625;28011936;31219806", "class_list": "glycogene", "function": "Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.47", "go_molecular_function": "GO:0008446 GDP-mannose 4,6-dehydratase activity;GO:0042802 identical protein binding;GO:0070401 NADP+ binding;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019673 GDP-mannose metabolic process;GO:0042351 'de novo' GDP-L-fucose biosynthetic process;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K0C9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FW57-1", "uniprot_id": "GLYAL_MOUSE", "mass": 34168.0, "length": 296, "protein_name": "Glycine N-acyltransferase-like protein", "gene_name": "Gm4952", "organism": "Mouse", "refseq_name": "glycine N-acyltransferase-like protein", "refseq_ac": "NP_001013784", "gene_names_uniprotkb": "Gm4952", "gene_names_refseq": "EG240549; Gm4952", "protein_names_uniprotkb": "Glycine N-acyltransferase-like protein; 2.3.1.13; AAc-like; Acyl-CoA:glycine N-acyltransferase-like", "protein_names_refseq": "glycine N-acyltransferase-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:240549)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;23576753;23806337", "class_list": "", "function": "Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QNP7", "ec_number_list": "2.3.1.13;2.3.1.-;2.3.1.71", "go_molecular_function": "GO:0047962 glycine N-benzoyltransferase activity;GO:0016410 N-acyltransferase activity;GO:0047961 glycine N-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006544 glycine metabolic process;GO:1901787 benzoyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5FW57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54897-1", "uniprot_id": "GPR27_MOUSE", "mass": 40036.0, "length": 379, "protein_name": "Probable G protein-coupled receptor 27", "gene_name": "Gpr27", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 27", "refseq_ac": "NP_032184", "gene_names_uniprotkb": "Gpr27; Sreb1", "gene_names_refseq": "Gpr27", "protein_names_uniprotkb": "Probable G protein-coupled receptor 27; Super conserved receptor expressed in brain 1", "protein_names_refseq": "probable G-protein coupled receptor 27; super conserved receptor expressed in brain 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14761); (R-MMU-418555)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "22253604;30084848;32221326;34428180;35326460;9479505", "class_list": "", "function": "Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes. Publication Status: Online-Only, [RefSeq, PubMed]; Orphan receptor. Possible candidate for amine-like G protein coupled receptor (By similarity)., [UniProtKB]; The Activation of GPR27 Increases Cytosolic L-Lactate in 3T3 Embryonic Cells and Astrocytes. Publication Status: Online-Only, [RefSeq, PubMed]; We identify a novel GPCR regulator of both insulin secretion and insulin promoter activity - Gpr27., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:1900738 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O54897-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70443-1", "uniprot_id": "GNAZ_MOUSE", "mass": 40850.0, "length": 355, "protein_name": "Guanine nucleotide-binding protein G(z) subunit alpha", "gene_name": "Gnaz", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(z) subunit alpha", "refseq_ac": "NP_034441", "gene_names_uniprotkb": "Gnaz", "gene_names_refseq": "Gnaz; Gz", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(z) subunit alpha; G(x) alpha chain; Gz-alpha", "protein_names_refseq": "g(x) alpha chain; guanine nucleotide-binding protein G(z) subunit alpha; gz-alpha", "tax_id": 10090, "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (mmu:14687); (R-MMU-418597)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "28419211;29088301;33300544;8013366", "class_list": "", "function": "Galphaz plays a key role in beta-cell signaling that becomes dysfunctional in the type 1 diabetes setting, accelerating the death of beta-cells, which promotes further accumulation of immune cells in the pancreatic islets, and inhibiting a restorative proliferative response., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB]; Present study suggest that Gnaz links the circadian clockwork-via dopamine acting on D4 receptors-to G protein-mediated signaling in intact but not diabetic retina Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70442;Q61637;Q91WM4", "ec_number_list": "", "go_molecular_function": "GO:0031821 G protein-coupled serotonin receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0046676 negative regulation of insulin secretion;GO:0098664 G protein-coupled serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70443-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88186-1", "uniprot_id": "GPIX_MOUSE", "mass": 19664.0, "length": 177, "protein_name": "Platelet glycoprotein IX", "gene_name": "Gp9", "organism": "Mouse", "refseq_name": "platelet glycoprotein IX precursor", "refseq_ac": "NP_061232", "gene_names_uniprotkb": "Gp9", "gene_names_refseq": "Cd42; GPIX; Gp9", "protein_names_uniprotkb": "Platelet glycoprotein IX; GP-IX; GPIX; Glycoprotein 9", "protein_names_refseq": "platelet glycoprotein IX precursor; platelet glycoprotein IX", "tax_id": 10090, "disease": "Bernard-Soulier syndrome (Disease Ontology:DOID:2217)", "pathway": " (mmu:54368); (R-MMU-430116); (R-MMU-76009); (R-MMU-9769739); (R-MMU-9769743); (R-MMU-9935598)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "19377075;24051142;24504734;9690810", "class_list": "", "function": "Findings point to a role of the GPIb-V-IX complex intrinsic to megakaryocytes at the stage of proplatelet formation and suggest a functional link with the underlying microtubular cytoskeleton in platelet biogenesis., [RefSeq, PubMed]; Platelet GP Ib-IX can be considered a multifunctional participant in hemostasis, thrombosis, and the inflammatory cascade., [RefSeq, PubMed]; The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib (By similarity)., [UniProtKB]; These data indicate an important role for the platelet adhesion receptor GPIb-IX in endotoxin-induced thrombosis and thrombocytopenia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:1990779 glycoprotein Ib-IX-V complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007597 blood coagulation, intrinsic pathway;GO:0007596 blood coagulation;GO:0051209 release of sequestered calcium ion into cytosol;GO:0035855 megakaryocyte development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88186-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08883-1", "uniprot_id": "GRAF_MOUSE", "mass": 27642.0, "length": 248, "protein_name": "Granzyme F", "gene_name": "Gzmf", "organism": "Mouse", "refseq_name": "granzyme F precursor", "refseq_ac": "NP_034504", "gene_names_uniprotkb": "Gzmf; Ccp4; Ctla-7; Ctla7", "gene_names_refseq": "CCP4; Ctla-7; Ctla7; Gzmf; MCSP-3", "protein_names_uniprotkb": "Granzyme F; 3.4.21.-; C134; CCP4; CTL serine protease 3; Cytotoxic cell protease 4; Cytotoxic serine protease 3; MCSP3", "protein_names_refseq": "AKA granzyme G; C134; CTL serine protease 3; MCSP3; cytotoxic cell protease 4; cytotoxic serine protease 3; granzyme F precursor; granzyme G", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); bronchiolitis obliterans (Disease Ontology:DOID:2799); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:14943)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1861068;1880801;19644510;2152187;25416787;3053963;3260382;3292281;3555842;38416029", "class_list": "", "function": "Granzyme F: Exhaustion Marker and Modulator of Chimeric Antigen Receptor T Cell-Mediated Cytotoxicity., [RefSeq, PubMed]; Nna1 and CCP4 remove the C-terminal glutamate from substrates with two or more glutamates, whereas CCP6 requires four or more glutamates. CCP4 behaves as a promiscuous glutamase with little preference for chain length or neighboring amino acid composition, [RefSeq, PubMed]; Serine protease probably necessary for target cell lysis in cell-mediated immune responses., [UniProtKB, PubMed, PubMed]; Showed that GzmF impairs mitochondrial electron transport to abolish ATP generation; ATP decline may contribute to a failure of apoptosome formation, leading to caspase inactivation., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0044194 cytolytic granule", "go_biological_process": "GO:0006508 proteolysis;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P08883-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C5I1-1", "uniprot_id": "GPR25_MOUSE", "mass": 38754.0, "length": 358, "protein_name": "C-X-C chemokine receptor GPR25", "gene_name": "Gpr25", "organism": "Mouse", "refseq_name": "C-X-C chemokine receptor GPR25", "refseq_ac": "NP_001094986", "gene_names_uniprotkb": "Gpr25; Gm1300", "gene_names_refseq": "Gm1300; Gpr25", "protein_names_uniprotkb": "C-X-C chemokine receptor GPR25; G protein-coupled receptor 25", "protein_names_refseq": "C-X-C chemokine receptor GPR25; probable G-protein coupled receptor 25", "tax_id": 10090, "disease": "", "pathway": " (mmu:383563); (R-MMU-418555)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for the C-X-C chemokine CXCL17, which plays a key role in lymphocyte homing. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway. Activation by CXCL17 on lymphocytes activates the RhoA pathway, which regulates cytoskeletal dynamics and integrins, mediating lymphocyte recruitment into the respiratory, upper gastrointestinal, biliary and genito-urinary tracts., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016494 C-X-C chemokine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0070098 chemokine-mediated signaling pathway;GO:0048247 lymphocyte chemotaxis;GO:0097021 lymphocyte migration into lymphoid organs;GO:0030595 leukocyte chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C5I1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C5J4-1", "uniprot_id": "GPR52_MOUSE", "mass": 41343.0, "length": 361, "protein_name": "G protein-coupled receptor 52", "gene_name": "Gpr52", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 52", "refseq_ac": "NP_001139802", "gene_names_uniprotkb": "Gpr52", "gene_names_refseq": "EG620246; Gpr52", "protein_names_uniprotkb": "G protein-coupled receptor 52", "protein_names_refseq": "G-protein coupled receptor 52; probable G-protein coupled receptor 52", "tax_id": 10090, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:620246)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "24587241;25738228;28583861;29608652;32519845;39242529", "class_list": "", "function": "Beta-Arrestin-2-Dependent Mechanism of GPR52 Signaling in Frontal Cortical Neurons., [RefSeq, PubMed]; G protein-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (By similarity). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241, PubMed:28583861). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; GPR52 has the potential of being a therapeutic psychiatric receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice. Publication Status: Online-Only, [RefSeq, PubMed]; This study demonstrated that the Knocking-out Gpr52 significantly reduces mutant HTT levels in the striatum and rescues Huntington's disease-associated behavioural phenotypes in a knock-in Huntington's disease mouse model expressing endogenous mutant Htt. Erratum:[Brain. 2020 Sep 1;143(9):e78. doi: 10.1093/brain/awaa192. PMID: 32746456], [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007626 locomotory behavior;GO:0009410 response to xenobiotic stimulus;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0C5J4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11033-1", "uniprot_id": "GRAD_MOUSE", "mass": 27955.0, "length": 252, "protein_name": "Granzyme D", "gene_name": "Gzmd", "organism": "Mouse", "refseq_name": "granzyme D precursor", "refseq_ac": "NP_034502", "gene_names_uniprotkb": "Gzmd", "gene_names_refseq": "CCP5; Ctla-5; Ctla5; Gzmd", "protein_names_uniprotkb": "Granzyme D; 3.4.21.-", "protein_names_refseq": "granzyme D precursor", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); bronchiolitis obliterans (Disease Ontology:DOID:2799); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:14941)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "23529614;3260382;3555842;8917549", "class_list": "", "function": "Serine protease probably necessary for target cell lysis in cell-mediated immune responses., [UniProtKB, PubMed]; These findings identify granzyme D as a novel murine mast cell protease and implicate granzyme D in settings where mast cells are activated, such as bacterial infection and allergy., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "P97387;Q3V2P1", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0044194 cytolytic granule", "go_biological_process": "GO:0006508 proteolysis;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P11033-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13366-1", "uniprot_id": "GRAG_MOUSE", "mass": 27381.0, "length": 248, "protein_name": "Granzyme G", "gene_name": "Gzmg", "organism": "Mouse", "refseq_name": "granzyme G precursor", "refseq_ac": "NP_034505", "gene_names_uniprotkb": "Gzmg", "gene_names_refseq": "Ctla-7; Ctla7; Gzmg", "protein_names_uniprotkb": "Granzyme G; 3.4.21.-; CTL serine protease 1; MCSP-1", "protein_names_refseq": "AKA granzyme G; CTL serine protease 1; CTL serine protease 3; MCSP-1; granzyme G precursor", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); bronchiolitis obliterans (Disease Ontology:DOID:2799); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:14944)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20704734;2611223;29237092;3053963;8917549", "class_list": "", "function": "Data suggest that granzyme G is an important factor in early mouse embryonic development and may play a novel role in the elimination of maternal proteins and the triggering of zygotic gene expression during the maternal-zygotic transition. Publication Status: Online-Only, [RefSeq, PubMed]; Serine protease probably necessary for target cell lysis in cell-mediated immune responses., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "P97388", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0044194 cytolytic granule", "go_biological_process": "GO:0006508 proteolysis;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P13366-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21278-1", "uniprot_id": "GNA11_MOUSE", "mass": 42024.0, "length": 359, "protein_name": "Guanine nucleotide-binding protein subunit alpha-11", "gene_name": "Gna11", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein subunit alpha-11", "refseq_ac": "NP_034431", "gene_names_uniprotkb": "Gna11; Gna-11", "gene_names_refseq": "Dsk7; E430025L19; Gna11; Hg1k; g alpha-11", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha-11; G alpha-11; G protein subunit alpha-11", "protein_names_refseq": "G-protein subunit alpha-11; guanine nucleotide-binding protein subunit alpha-11; heterotrimeric guanine nucleotide-binding protein 1k", "tax_id": 10090, "disease": "familial hypocalciuric hypercalcemia 2 (Disease Ontology:DOID:0060701); autosomal dominant hypocalcemia 2 (Disease Ontology:DOID:0090108); McCune Albright syndrome (Disease Ontology:DOID:1858); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14672); (R-MMU-112043); (R-MMU-202040); (R-MMU-399997); (R-MMU-416476); (R-MMU-418592); (R-MMU-428930); (R-MMU-434316); (R-MMU-456926); (R-MMU-6814122); (R-MMU-9856530); (R-MMU-9860927)", "pathway_count": 12, "publication_count": 11, "publication_id_list": "20173027;2123549;2508088;28315936;31219806;32152506;33300544;34428180;38530370;8838318;9687499", "class_list": "", "function": "Galpha11 deficiency increases fibroblast growth factor 23 levels in a mouse model of familial hypocalciuric hypercalcemia. Publication Status: Online-Only, [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:9687499). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:9687499). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:9687499). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:9687499). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:9687499). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:9687499). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNAQ, required for heart development (PubMed:9687499). In the respiratory epithelium, transmits OXGR1-dependent signals that lead to downstream intracellular Ca(2+) release and mucocilliary clearance of airborne pathogens., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61939", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0086100 endothelin receptor signaling pathway;GO:0045634 regulation of melanocyte differentiation;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P21278-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21765-1", "uniprot_id": "GPX5_MOUSE", "mass": 25393.0, "length": 221, "protein_name": "Epididymal secretory glutathione peroxidase", "gene_name": "Gpx5", "organism": "Mouse", "refseq_name": "epididymal secretory glutathione peroxidase precursor", "refseq_ac": "NP_034473", "gene_names_uniprotkb": "Gpx5", "gene_names_refseq": "Arep; Gpx5", "protein_names_uniprotkb": "Epididymal secretory glutathione peroxidase; 1.11.1.9; EGLP; Epididymis-specific glutathione peroxidase-like protein; GPx-5; GSHPx-5; Glutathione peroxidase 5; Major androgen-regulated protein; arMEP24", "protein_names_refseq": "EGLP; GPx-5; GSHPx-5; arMEP24; epididymal secretory glutathione peroxidase precursor; epididymal secretory glutathione peroxidase; epididymis-specific glutathione peroxidase-like protein; lysosomal trafficking regulator, long splice form; major androgen-regulated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:14780); (R-MMU-3299685)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1913244;2263479;32270769;38666419;8469239", "class_list": "", "function": "Exploring novel function of Gpx5 antioxidant activity: Assisting epididymal cells secrete functional extracellular vesicles., [RefSeq, PubMed]; Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice., [RefSeq, PubMed]; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QK84", "ec_number_list": "1.11.1.12;1.11.1.9;1.11.1.27;1.16.3.1;1.16.3.4", "go_molecular_function": "GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0097524 sperm plasma membrane", "go_biological_process": "GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P21765-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30677-1", "uniprot_id": "GNA14_MOUSE", "mass": 41528.0, "length": 355, "protein_name": "Guanine nucleotide-binding protein subunit alpha-14", "gene_name": "Gna14", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein subunit alpha-14", "refseq_ac": "NP_032163", "gene_names_uniprotkb": "Gna14; Gna-14", "gene_names_refseq": "Gna14; Hg1i", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha-14; G alpha-14; G protein subunit alpha-14", "protein_names_refseq": "G-protein subunit alpha-14; g alpha-14; guanine nucleotide-binding protein subunit alpha-14; heterotrimeric guanine nucleotide-binding protein 1i", "tax_id": 10090, "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14675); (R-MMU-112043); (R-MMU-202040); (R-MMU-399997); (R-MMU-416476); (R-MMU-418592); (R-MMU-428930); (R-MMU-434316); (R-MMU-456926); (R-MMU-6814122)", "pathway_count": 10, "publication_count": 5, "publication_id_list": "1946421;21750661;2508088;33300544;34428180", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2X9", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0086100 endothelin receptor signaling pathway;GO:0045634 regulation of melanocyte differentiation;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P30677-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30678-1", "uniprot_id": "GNA15_MOUSE", "mass": 43536.0, "length": 374, "protein_name": "Guanine nucleotide-binding protein subunit alpha-15", "gene_name": "Gna15", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein subunit alpha-15", "refseq_ac": "NP_034434", "gene_names_uniprotkb": "Gna15; Gna-15", "gene_names_refseq": "G[a]15; Galpha15; Gna15; Hg1l", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha-15; G alpha-15; G protein subunit alpha-15", "protein_names_refseq": "G-protein subunit alpha-15; g alpha-15; guanine nucleotide-binding protein subunit alpha-15; heterotrimeric guanine nucleotide-binding protein 1l", "tax_id": 10090, "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (mmu:14676)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12401211;1946421;27869740;34428180;8838318", "class_list": "", "function": "Data indicate that the hydrophobic core buried between helix 8 and TM1-2 of olfactory receptor (mOR-S6) is important for the activation of both G protein alpha 15 (Galpha15). Review article Publication Status: Online-Only, [RefSeq, PubMed]; Member of the G protein alpha subunit family that plays a crucial role in intracellular signaling. Functions as a molecular switch, transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. In collaboration with the adapter protein TTC1, promotes HRAS activation and ERK1/2 phosphorylation independently of phospholipase Cbeta signaling. Also initiates EMR2-mediated signaling, leading to activation of Akt, MAPK, and NF-kappa-B, which in turn drives macrophage differentiation and inflammatory responses., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1S0", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0019722 calcium-mediated signaling;GO:0001508 action potential;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P30678-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48540-1", "uniprot_id": "GDNF_MOUSE", "mass": 23662.0, "length": 211, "protein_name": "Glial cell line-derived neurotrophic factor", "gene_name": "Gdnf", "organism": "Mouse", "refseq_name": "glial cell line-derived neurotrophic factor isoform 2 precursor", "refseq_ac": "NP_001288261", "gene_names_uniprotkb": "Gdnf", "gene_names_refseq": "ATF; Gdnf", "protein_names_uniprotkb": "Glial cell line-derived neurotrophic factor; ATF; Astrocyte-derived trophic factor; mGDNF", "protein_names_refseq": "astrocyte-derived trophic factor; glial cell line-derived neurotrophic factor isoform 2 precursor; neurotrophic factor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); Kennedy's disease (Disease Ontology:DOID:0060161); alcohol-associated liver disease (Disease Ontology:DOID:0070658); Parkinsonism (Disease Ontology:DOID:0080855); Hirschsprung's disease (Disease Ontology:DOID:10487); Alzheimer's disease (Disease Ontology:DOID:10652); obsessive-compulsive disorder (Disease Ontology:DOID:10933); sciatic neuropathy (Disease Ontology:DOID:11446); acoustic neuroma (Disease Ontology:DOID:12689); hyperprolactinemia (Disease Ontology:DOID:12700); Guillain-Barre syndrome (Disease Ontology:DOID:12842); Sjogren's syndrome (Disease Ontology:DOID:12894); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); glomerulonephritis (Disease Ontology:DOID:2921); Churg-Strauss syndrome (Disease Ontology:DOID:3049); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); neuromuscular disease (Disease Ontology:DOID:440); amphetamine abuse (Disease Ontology:DOID:670); irritable bowel syndrome (Disease Ontology:DOID:9778); polyarteritis nodosa (Disease Ontology:DOID:9810); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:14573); (R-MMU-5673001); (R-MMU-8853659)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12168040;21994944;7650763;8808409;9426245", "class_list": "", "function": "Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor. Involved in the development of the neural crest., [UniProtKB, UniProtKB]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Homozygous knockout mice for this gene exhibit defects in kidney development and neonatal death. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O09058;P70446;P97919;P97920;Q6LEL9", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005160 transforming growth factor beta receptor binding;GO:0030971 receptor tyrosine kinase binding;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0043235 receptor complex", "go_biological_process": "GO:0001759 organ induction;GO:0030432 peristalsis;GO:0051584 regulation of dopamine uptake involved in synaptic transmission;GO:0048484 enteric nervous system development;GO:0021516 dorsal spinal cord development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P48540-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56400-1", "uniprot_id": "GP1BB_MOUSE", "mass": 21763.0, "length": 206, "protein_name": "Platelet glycoprotein Ib beta chain", "gene_name": "Gp1bb", "organism": "Mouse", "refseq_name": "platelet glycoprotein Ib beta chain isoform 2 precursor", "refseq_ac": "NP_034457", "gene_names_uniprotkb": "Gp1bb", "gene_names_refseq": "Gp1bb", "protein_names_uniprotkb": "Platelet glycoprotein Ib beta chain; GP-Ib beta; GPIb-beta; GPIbB", "protein_names_refseq": "GP-Ib beta; GPIb-beta; GPIbB; platelet glycoprotein Ib beta chain isoform 2 precursor; platelet glycoprotein Ib beta chain", "tax_id": 10090, "disease": "Bernard-Soulier syndrome (Disease Ontology:DOID:2217)", "pathway": " (mmu:14724); (R-MMU-430116); (R-MMU-76009); (R-MMU-9769739); (R-MMU-9769743); (R-MMU-9935598)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "17242355;21183079;27148783;28943410;34732055;9259114", "class_list": "", "function": "Early Endosomal GTPase Rab5 (Ras-Related Protein in Brain 5) Regulates GPIbbeta (Glycoprotein Ib Subunit beta) Trafficking and Platelet Production In Vitro., [RefSeq, PubMed]; GPIbbeta has a repressor function in thrombus formation Erratum:[J Thromb Haemost. 2017 Jan;15(1):208. doi: 10.1111/jth.13522. PMID: 28133955], [RefSeq, PubMed]; Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium., [UniProtKB]; These results indicate that Reelin is an important regulator of GPIb-mediated platelet activation and may represent a new therapeutic target for the prevention and treatment of cardio- and cerebrovascular diseases, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:1990779 glycoprotein Ib-IX-V complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007597 blood coagulation, intrinsic pathway;GO:0007596 blood coagulation;GO:0051209 release of sequestered calcium ion into cytosol;GO:0035855 megakaryocyte development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P56400-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56916-1", "uniprot_id": "GSC2_MOUSE", "mass": 22022.0, "length": 201, "protein_name": "Homeobox protein goosecoid-2", "gene_name": "Gsc2", "organism": "Mouse", "refseq_name": "homeobox protein goosecoid-2", "refseq_ac": "NP_083745", "gene_names_uniprotkb": "Gsc2; Gscl", "gene_names_refseq": "4930568H22Rik; GSC-2; Gsc2; Gscl", "protein_names_uniprotkb": "Homeobox protein goosecoid-2; GSC-2; GSC-L; Homeobox protein goosecoid-like", "protein_names_refseq": "GSC-L; homeobox protein goosecoid-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:195333)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20921407;21750661;9037598;9441739", "class_list": "", "function": "May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC., [UniProtKB, UniProtKB, UniProtKB]; Results indicate that the absence of Gscl and Dgcr14 in the IP results in altered regulation of REM sleep, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RTU1;Q05A98", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P56916-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60894-1", "uniprot_id": "GPR85_MOUSE", "mass": 41995.0, "length": 370, "protein_name": "Probable G protein-coupled receptor 85", "gene_name": "Gpr85", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 85", "refseq_ac": "NP_001317595", "gene_names_uniprotkb": "Gpr85; Sreb2", "gene_names_refseq": "2900026B03Rik; Gpr85", "protein_names_uniprotkb": "Probable G protein-coupled receptor 85; Super conserved receptor expressed in brain 2", "protein_names_refseq": "probable G-protein coupled receptor 85; super conserved receptor expressed in brain 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:64450)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10978537;18413613;22697179;35194900;35820727", "class_list": "", "function": "Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain., [RefSeq, PubMed]; Orphan receptor., [UniProtKB]; The results indicate that SREB2 is a negative regulator of adult neurogenesis and consequential cognitive functions., [RefSeq, PubMed]; Theses data implicate SREB2 as a potential risk factor for psychiatric disorders., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHI6;Q9NPD1", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P60894-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01776-1", "uniprot_id": "GNRHR_MOUSE", "mass": 37684.0, "length": 327, "protein_name": "Gonadotropin-releasing hormone receptor", "gene_name": "Gnrhr", "organism": "Mouse", "refseq_name": "gonadotropin-releasing hormone receptor isoform 1", "refseq_ac": "NP_034453", "gene_names_uniprotkb": "Gnrhr", "gene_names_refseq": "Gnrhr", "protein_names_uniprotkb": "Gonadotropin-releasing hormone receptor; GnRH receptor; GnRH-R", "protein_names_refseq": "gnRH receptor; gonadotropin-releasing hormone receptor isoform 1", "tax_id": 10090, "disease": "primary sclerosing cholangitis (Disease Ontology:DOID:0060643); hypogonadotropic hypogonadism 7 with or without anosmia (Disease Ontology:DOID:0090078); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14715); (R-MMU-375281); (R-MMU-416476)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1324422;1328228;21750661;23371388;37828510;38348415;7768336", "class_list": "", "function": "AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Functional GnRH receptor signaling regulates striatal cholinergic neurons in neonatal but not in adult mice. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61611", "ec_number_list": "", "go_molecular_function": "GO:0004968 gonadotropin-releasing hormone receptor activity;GO:0016520 growth hormone-releasing hormone receptor activity;GO:0016500 protein-hormone receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q01776-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VDU3-1", "uniprot_id": "GPR15_MOUSE", "mass": 40542.0, "length": 360, "protein_name": "G protein-coupled receptor 15", "gene_name": "Gpr15", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 15", "refseq_ac": "NP_001156427", "gene_names_uniprotkb": "Gpr15", "gene_names_refseq": "4933439K08Rik; Gpr15", "protein_names_uniprotkb": "G protein-coupled receptor 15", "protein_names_refseq": "G-protein coupled receptor 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:71223); (R-MMU-418555)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "23661644;24838826;28078348;28386128;35820727;38243565;38459169", "class_list": "", "function": "Blocking GPR15 Counteracts Integrin-dependent T Cell Gut Homing in Vivo., [RefSeq, PubMed]; Findings describe a T cell-homing receptor for large intestine lamina propria and indicate that GPR15 plays a role in mucosal immune tolerance largely by regulating the influx of Tregs, [RefSeq, PubMed]; Findings establish a role for GPR15 in skin lymphocyte homing and suggest that it may contribute to lymphocyte subset targeting to diverse epithelial sites., [RefSeq, PubMed]; G protein-coupled receptor that plays an important role in immune homeostasis. Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells (By similarity). Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria (PubMed:23661644). Also required for skin localization of thymus-derived dendritic epidermal T-cells (PubMed:24838826). Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin (PubMed:28386128). Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The fifth epidermal growth factor like region of thrombomodulin exerts anti-inflammatory function by inhibiting NF-kappaB in a GPR15-dependent manner., [RefSeq, PubMed]; Thrombin receptor activating peptide-6 decreases acute graft-versus-host disease through activating GPR15., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKY6;Q3B800", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0015026 coreceptor activity;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0046718 symbiont entry into host cell;GO:0072678 T cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q0VDU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U507-1", "uniprot_id": "GP174_MOUSE", "mass": 38761.0, "length": 335, "protein_name": "Probable G protein-coupled receptor 174", "gene_name": "Gpr174", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 174", "refseq_ac": "NP_001028423", "gene_names_uniprotkb": "Gpr174; Gm376", "gene_names_refseq": "Gm376; Gpr174; Lypsr3", "protein_names_uniprotkb": "Probable G protein-coupled receptor 174", "protein_names_refseq": "probable G-protein coupled receptor 174; putative purinergic receptor FKSG79", "tax_id": 10090, "disease": "", "pathway": " (mmu:213439)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "20173027;23178570;25605945;26077720;29457279;30084848;30779550;30850582;31875850;34428180;35639700;36473866", "class_list": "", "function": "G protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response. Plays a negative role in regulatory T-cell accumulation and homeostasis (PubMed:26077720). Under inflammatory conditions where LysoPS production increases, contributes to the down-regulation of regulatory T-cell activity to favor effector response (PubMed:26077720). Mediates the suppression of IL-2 production in activated T-lymphocytes leading to inhibition of growth, proliferation and differentiation of T-cells (PubMed:29457279). Mechanistically, acts via G(s)-containing heterotrimeric G proteins to trigger elevated cyclic AMP levels and protein kinase A/PKA activity, which may in turn act to antagonize proximal TCR signaling (PubMed:29457279). Plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions (PubMed:30850582). Upon testosterone treatment, acts as a receptor for CCL21 and subsequently triggers through G(q)-alpha and G(12)/G(13) proteins a calcium flux leading to chemotactic effects on activated B-cells (PubMed:31875850). Signals via GNA13 and PKA to promote CD86 up-regulation by follicular B-cells (PubMed:35639700)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression. Publication Status: Online-Only, [RefSeq, PubMed]; GPR174 signals via Galphas to control a CD86-containing gene expression program in B cells., [RefSeq, PubMed]; Lysophosphatidyl serine acts via GPR174 and Galphas to suppress IL-2 production by activated T cells, [RefSeq, PubMed]; The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0045125 bioactive lipid receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034451 centriolar satellite", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0043029 T cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3U507-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UJF0-1", "uniprot_id": "GPR55_MOUSE", "mass": 38090.0, "length": 327, "protein_name": "G protein-coupled receptor 55", "gene_name": "Gpr55", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 55", "refseq_ac": "NP_001028462", "gene_names_uniprotkb": "Gpr55; Gm218", "gene_names_refseq": "CTFL; Gm218; Gpr55; Lpir1", "protein_names_uniprotkb": "G protein-coupled receptor 55", "protein_names_refseq": "G-protein coupled receptor 55", "tax_id": 10090, "disease": "", "pathway": " (mmu:227326); (R-MMU-373076); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "18502582;19464294;36523570;36898418;38374108;39113250", "class_list": "", "function": "G protein-coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation. In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation. May be involved in hyperalgesia associated with inflammatory and neuropathic pain (PubMed:18502582)., [UniProtKB, PubMed, UniProtKB]; GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice. Publication Status: Online-Only, [RefSeq, PubMed]; GPR55 might be involved in neuroinflammation and its expression is controlled by the state of microglial activation., [RefSeq, PubMed]; Global deletion of G protein-coupled receptor 55 impairs glucose homeostasis during obesity by reducing insulin secretion and beta-cell turnover., [RefSeq, PubMed]; In a model of neuropathic hypersensitivity, there is no mechanical hyperalgesia present in male or female GPR55-deficient mice at any time point up to 28 days post-ligation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004949 cannabinoid receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0045453 bone resorption;GO:0035025 positive regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UJF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UVY1-1", "uniprot_id": "GP149_MOUSE", "mass": 80520.0, "length": 732, "protein_name": "Probable G protein-coupled receptor 149", "gene_name": "Gpr149", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 149 isoform 1", "refseq_ac": "NP_796320", "gene_names_uniprotkb": "Gpr149; Pgr10", "gene_names_refseq": "9630018L10Rik; Gpr149; Ieda; PGR10; R35", "protein_names_uniprotkb": "Probable G protein-coupled receptor 149; G protein-coupled receptor PGR10", "protein_names_refseq": "G protein-coupled receptor PGR10; probable G-protein coupled receptor 149 isoform 1; probable G-protein coupled receptor 149", "tax_id": 10090, "disease": "", "pathway": " (mmu:229357)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12679517;15592455;19887567;35758525;38282864", "class_list": "", "function": "Gpr149 is involved in energy homeostasis in the male mouse. Publication Status: Online-Only, [RefSeq, PubMed]; Gpr149 null mice are one of the few models with enhanced fertility., [RefSeq, PubMed]; Orphan receptor., [UniProtKB]; The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMB1;Q80T52;Q8BXA3;Q8BZC0", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0001547 antral ovarian follicle growth;GO:0007218 neuropeptide signaling pathway;GO:0001546 preantral ovarian follicle growth;GO:0060280 negative regulation of ovulation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UVY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V3I2-1", "uniprot_id": "GNAT3_MOUSE", "mass": 40316.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein G(t) subunit alpha-3", "gene_name": "Gnat3", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(t) subunit alpha-3", "refseq_ac": "NP_001074612", "gene_names_uniprotkb": "Gnat3", "gene_names_refseq": "Ggust; Gnat3; Gtn; Hg1e", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(t) subunit alpha-3; Gustducin alpha-3 chain", "protein_names_refseq": "alpha-gustducin; guanine nucleotide binding protein, alpha transducing 3; guanine nucleotide-binding protein G(t) subunit alpha-3; gustducin alpha-3 chain; heterotrimeric guanine nucleotide-binding protein 1e", "tax_id": 10090, "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (mmu:242851); (R-MMU-170670); (R-MMU-381771); (R-MMU-392170); (R-MMU-418594); (R-MMU-9009391); (R-MMU-9717207)", "pathway_count": 7, "publication_count": 19, "publication_id_list": "10407021;10570481;11245589;11447270;14586025;14627646;14637165;15342734;16740645;16933139;17021831;17229761;17290008;17724330;17724332;31656004;32882403;34428180;8657284", "class_list": "", "function": "Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Also functions as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Spleen lymphocytes with gustducin signaling may be involved in T-dependent immune response to the blood bacterial polysaccharides., [RefSeq, PubMed]; The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0001669 acrosomal vesicle;GO:0005930 axoneme", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035094 response to nicotine;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007603 phototransduction, visible light;GO:0050908 detection of light stimulus involved in visual perception", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q3V3I2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P9S7-1", "uniprot_id": "GLT10_MOUSE", "mass": 69116.0, "length": 603, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 10", "gene_name": "Galnt10", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 10", "refseq_ac": "NP_598950", "gene_names_uniprotkb": "Galnt10", "gene_names_refseq": "C330012K04Rik; GalNAc-T10; GalNAc-T9; Galnt10; Galnt9; ppGaNTase", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 10; 2.4.1.41; GalNAc-T10; Polypeptide GalNAc transferase 10; Protein-UDP acetylgalactosaminyltransferase 10; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10; pp-GaNTase 10", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10; UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 9; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10; polypeptide GalNAc transferase 10; polypeptide N-acetylgalactosaminyltransferase 10; pp-GaNTase 10; protein-UDP acetylgalactosaminyltransferase 10", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:171212); (R-MMU-913709)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11278534;15018805;21750661;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates (By similarity)., [UniProtKB]; GALNT10 exhibits predominant expression in the hypothalamus, thalamus and amygdala of mouse forebrain, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 42, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAQ2;Q8BZU8;Q91YJ6", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 0.5, "record_id": "Q6P9S7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61011-1", "uniprot_id": "GBB3_MOUSE", "mass": 37240.0, "length": 340, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3", "gene_name": "Gnb3", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3", "refseq_ac": "NP_038558", "gene_names_uniprotkb": "Gnb3", "gene_names_refseq": "Gnb-3; Gnb3; Hg2d", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Transducin beta chain 3", "protein_names_refseq": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; heterotrimeric guanine nucleotide-binding protein 2d; transducin beta chain 3", "tax_id": 10090, "disease": "congenital stationary night blindness 1H (Disease Ontology:DOID:0110866); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); familial hyperlipidemia (Disease Ontology:DOID:1168); depressive disorder (Disease Ontology:DOID:1596); carotid artery disease (Disease Ontology:DOID:3407); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:14695); (R-MMU-1296041); (R-MMU-202040); (R-MMU-381676); (R-MMU-381771); (R-MMU-392170); (R-MMU-392451); (R-MMU-392851); (R-MMU-400042); (R-MMU-4086398); (R-MMU-416476); (R-MMU-416482); (R-MMU-418217); (R-MMU-418555); (R-MMU-418592); (R-MMU-418594); (R-MMU-418597); (R-MMU-420092); (R-MMU-428930); (R-MMU-432040); (R-MMU-456926); (R-MMU-500657); (R-MMU-6814122); (R-MMU-8964315); (R-MMU-8964616); (R-MMU-9009391); (R-MMU-9634597); (R-MMU-9717207); (R-MMU-9856530); (R-MMU-997272)", "pathway_count": 30, "publication_count": 2, "publication_id_list": "8858601;9445485", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0030507 spectrin binding;GO:0051020 GTPase binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0044297 cell body;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0090181 regulation of cholesterol metabolic process;GO:0010906 regulation of glucose metabolic process;GO:0006884 cell volume homeostasis;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q61011-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61606-1", "uniprot_id": "GLR_MOUSE", "mass": 54929.0, "length": 485, "protein_name": "Glucagon receptor", "gene_name": "Gcgr", "organism": "Mouse", "refseq_name": "glucagon receptor isoform 1 precursor", "refseq_ac": "NP_032127", "gene_names_uniprotkb": "Gcgr", "gene_names_refseq": "GR; Gcgr", "protein_names_uniprotkb": "Glucagon receptor; GL-R", "protein_names_refseq": "GL-R; glucagon receptor isoform 1 precursor", "tax_id": 10090, "disease": "Mahvash Disease (Disease Ontology:DOID:0112306); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:14527); (R-MMU-163359); (R-MMU-416476); (R-MMU-418555); (R-MMU-420092)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "12552113;16627579;19046568;32677665;34428180;7590348;8156917", "class_list": "", "function": "G protein-coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q63960;Q8K0B5", "ec_number_list": "", "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004967 glucagon receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0042594 response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61606-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PE65-1", "uniprot_id": "GPT2L_MOUSE", "mass": 53989.0, "length": 482, "protein_name": "G patch domain-containing protein 2-like", "gene_name": "Gpatch2l", "organism": "Mouse", "refseq_name": "G patch domain-containing protein 2-like isoform 2", "refseq_ac": "NP_001311417", "gene_names_uniprotkb": "Gpatch2l; Kiaa1152", "gene_names_refseq": "1700020O03Rik; 4732487G21Rik; A630090I05Rik; Gpatch2l; Kiaa1152", "protein_names_uniprotkb": "G patch domain-containing protein 2-like", "protein_names_refseq": "G patch domain-containing protein 2-like isoform 2; G patch domain-containing protein 2-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:70373)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPW9;Q8CD08;Q9DA49", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PE65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PI62-1", "uniprot_id": "GP173_MOUSE", "mass": 41511.0, "length": 373, "protein_name": "Probable G protein-coupled receptor 173", "gene_name": "Gpr173", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 173", "refseq_ac": "NP_001300677", "gene_names_uniprotkb": "Gpr173; Sreb3", "gene_names_refseq": "3230401K02Rik; Gpr173; Sreb3", "protein_names_uniprotkb": "Probable G protein-coupled receptor 173; Super conserved receptor expressed in brain 3", "protein_names_refseq": "G protein-coupled receptor SREB3; probable G-protein coupled receptor 173; super conserved receptor expressed in brain 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:70771)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "27268078;30251651;30716364;30933929;36813575", "class_list": "", "function": "A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition., [RefSeq, PubMed]; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (PubMed:27268078). It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (PubMed:27268078). In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth (PubMed:30933929)., [UniProtKB, PubMed, PubMed]; Study reports that Gpr173 is downregulated by palmitate and BPA in hypothalamic neuronal cell lines and primary culture, both partially mediated by MAPK p38 pathway. Also, palmitate impairs the capacity of the GPR173 putative ligand, PNX, to activate signaling in hypothalamic neurons. These findings contribute to the understanding of how fats and endocrine disruptors affect reproductive function., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AHI2;Q4VA66", "ec_number_list": "", "go_molecular_function": "GO:0004968 gonadotropin-releasing hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:2001223 negative regulation of neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PI62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSN6-1", "uniprot_id": "GP151_MOUSE", "mass": 46826.0, "length": 422, "protein_name": "G protein-coupled receptor 151 protein", "gene_name": "Gpr151", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 151 protein", "refseq_ac": "NP_853521", "gene_names_uniprotkb": "Gpr151; Pgr7", "gene_names_refseq": "C130082O03Rik; GalRL; Gpr151; PGR7; nGPCR-2037", "protein_names_uniprotkb": "G protein-coupled receptor 151 protein; G protein-coupled receptor PGR7; GPCR-2037", "protein_names_refseq": "G-protein coupled receptor 151 protein; G-protein coupled receptor PGR7; GPCR-2037; probable G-protein coupled receptor 151 protein; putative G protein-coupled receptor nGPCR-2037", "tax_id": 10090, "disease": "", "pathway": " (mmu:240239)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12679517;14667573;15111018;25116430;25605945;32098843;33239523;35820727;36424418", "class_list": "", "function": "G protein-coupled receptor GPR151 is involved in trigeminal neuropathic pain through the induction of Gbetagamma/extracellular signal-regulated kinase-mediated neuroinflammation in the trigeminal ganglion., [RefSeq, PubMed]; Galanin-receptor like (GalRL) expression is found in the dorsal thalamus; hybridization signals are detected in the striatum, the locus coeruleus, and several hindbrain nuclei., [RefSeq, PubMed]; Proton-sensing G protein-coupled receptor., [UniProtKB, UniProtKB]; The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula. Publication Status: Online-Only, [RefSeq, PubMed]; These data identify GPR151 as a critical modulator of habenular function that controls nicotine addiction vulnerability, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBS2;Q80UD8;Q8BX88", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0042734 presynaptic membrane;GO:0098981 cholinergic synapse", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0010447 response to acidic pH;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TSN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUD0-1", "uniprot_id": "GPR4_MOUSE", "mass": 41105.0, "length": 365, "protein_name": "G protein-coupled receptor 4", "gene_name": "Gpr4", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 4", "refseq_ac": "NP_783599", "gene_names_uniprotkb": "Gpr4", "gene_names_refseq": "Gpr4; mmGPR4", "protein_names_uniprotkb": "G protein-coupled receptor 4; mmGPR4", "protein_names_refseq": "G-protein coupled receptor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:319197); (R-MMU-373076); (R-MMU-416476)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "17145776;20798260;21917373;26068853;31896584;32058960;35165253;39753131", "class_list": "", "function": "Findings suggest that GPR4 activation by an acidic pH inhibits tumor cell migration and invasion, and the Rho GTPase is at least partly responsible for this phenotype, [RefSeq, PubMed]; PH sensor with an important role in regulating acid secretion in the kidney collecting duct, [RefSeq, PubMed]; Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:17145776, PubMed:20798260, PubMed:26068853, PubMed:39753131). Activated by an optimal pH of 6.8-7.2 (PubMed:39753131). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:20798260, PubMed:39753131). GPR4 is mainly coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:20798260, PubMed:39753131). May also couple with G(i), G(q) and G(12)/G(13) G proteins (PubMed:17145776, PubMed:39753131). Acts as a key regulator of respiratory sensitivity to CO2/H(+) in brain retrotrapezoid nucleus neurons: acts by mediating detection of protons generated by the formation of carbonic acid in the blood, an important mechanism to impulse to breathe (PubMed:26068853, PubMed:31896584). Also acts as a regulator of acid secretion in the kidney collecting duct by maintaining acid-base homeostasis in the kidney (PubMed:20798260). Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells, possibly through the G(12)/G(13)/Rho GTPase signaling pathway (PubMed:32058960)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest that GPR4 deficiency leads to partially penetrant vascular abnormalities during development and that this receptor functions in blood vessel pH sensing., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0030155 regulation of cell adhesion;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0043114 regulation of vascular permeability", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BUD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXS7-1", "uniprot_id": "GP152_MOUSE", "mass": 55420.0, "length": 511, "protein_name": "Probable G protein-coupled receptor 152", "gene_name": "Gpr152", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 152", "refseq_ac": "NP_996856", "gene_names_uniprotkb": "Gpr152", "gene_names_refseq": "A930009H15Rik; Ackr5; Gm673; Gpr152", "protein_names_uniprotkb": "Probable G protein-coupled receptor 152", "protein_names_refseq": "G protein-coupled receptor 152; probable G-protein coupled receptor 152; putative G-protein coupled receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:269053)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Orphan receptor., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q499X3", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BXS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYC4-1", "uniprot_id": "GPR20_MOUSE", "mass": 39432.0, "length": 358, "protein_name": "G protein-coupled receptor 20", "gene_name": "Gpr20", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 20", "refseq_ac": "NP_775541", "gene_names_uniprotkb": "Gpr20", "gene_names_refseq": "A430106B11Rik; Gpr20", "protein_names_uniprotkb": "G protein-coupled receptor 20", "protein_names_refseq": "G protein-coupled receptor GPR20; G-protein coupled receptor 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:239530); (R-MMU-418555)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12679517;18347022", "class_list": "", "function": "Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80T63", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BYC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZR0-1", "uniprot_id": "GPR82_MOUSE", "mass": 37555.0, "length": 328, "protein_name": "Probable G protein-coupled receptor 82", "gene_name": "Gpr82", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 82", "refseq_ac": "NP_783600", "gene_names_uniprotkb": "Gpr82", "gene_names_refseq": "Gpr82", "protein_names_uniprotkb": "Probable G protein-coupled receptor 82", "protein_names_refseq": "G protein-coupled receptor GPR82; probable G-protein coupled receptor 82", "tax_id": 10090, "disease": "", "pathway": " (mmu:319200)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12679517;22216272;34428180", "class_list": "", "function": "GPR82-deficient mice showed decreased serum triacylglyceride levels, increased insulin sensitivity and glucose tolerance, most pronounced under Western diet, [RefSeq, PubMed]; Orphan receptor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80UB1", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0060612 adipose tissue development;GO:0032094 response to food;GO:0097009 energy homeostasis;GO:0032868 response to insulin", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BZR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4Z6-1", "uniprot_id": "GPC6A_MOUSE", "mass": 104213.0, "length": 928, "protein_name": "G protein-coupled receptor family C group 6 member A", "gene_name": "Gprc6a", "organism": "Mouse", "refseq_name": "G-protein coupled receptor family C group 6 member A precursor", "refseq_ac": "NP_694711", "gene_names_uniprotkb": "Gprc6a", "gene_names_refseq": "Gprc6a", "protein_names_uniprotkb": "G protein-coupled receptor family C group 6 member A", "protein_names_refseq": "G-protein coupled receptor family C group 6 member A precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:210198); (R-MMU-416476); (R-MMU-420499)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15576628;15816861;16199532;19050760;20947496;21333348;25428506;35134872;36257460;37828378", "class_list": "", "function": "Cloning and characterization of mouse GPRC6A family C orphan receptor show the highest degree of amino acid identity to the fish 5.24 odorant receptor and mammalian calcium-sensing receptor (CaSR)., [RefSeq, PubMed]; Extracellular Ca[2+] aggravates IgE-induced allergic reaction in mast cells through GPRC6A, a novel family C G-protein-coupled receptor., [RefSeq, PubMed]; GPRC6A is a cation-, calcimimetic-, and osteocalcin-sensing receptor, [RefSeq, PubMed]; GPRC6A is a promiscuous L-alpha-amino acid receptor most potently activated by basic amino acids., [RefSeq, PubMed]; Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations (PubMed:15576628, PubMed:16199532, PubMed:21333348). Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids (PubMed:15576628). The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+) (PubMed:16199532). Seems to act through a G(q)/G(11) and G(i)-coupled pathway (PubMed:15576628, PubMed:16199532). Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (PubMed:21333348). Mediates the non-genomic effects of androgens in multiple tissue (PubMed:19050760). May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (PubMed:19050760, PubMed:20947496)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Role of Nutrient-sensing Receptor GPRC6A in Regulating Colonic Group 3 Innate Lymphoid Cells and Inflamed Mucosal Healing., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5DK51;Q5DK52", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019722 calcium-mediated signaling;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0043200 response to amino acid", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K4Z6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R5M0-1", "uniprot_id": "GIPC3_MOUSE", "mass": 32108.0, "length": 297, "protein_name": "PDZ domain-containing protein GIPC3", "gene_name": "Gipc3", "organism": "Mouse", "refseq_name": "PDZ domain-containing protein GIPC3 isoform 3", "refseq_ac": "NP_683753", "gene_names_uniprotkb": "Gipc3; Rgs19ip3", "gene_names_refseq": "Ahl5; Gipc3; Rgs19ip3", "protein_names_uniprotkb": "PDZ domain-containing protein GIPC3; Regulator of G protein signaling 19-interacting protein 3", "protein_names_refseq": "PDZ domain-containing protein GIPC3 isoform 3; PDZ domain-containing protein GIPC3; age related hearing loss 5; regulator of G-protein signaling 19 interacting protein 3", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 15 (Disease Ontology:DOID:0110470); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:209047)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11836631;21326233;29021281;34224745;37096733", "class_list": "", "function": "A PDZ Protein GIPC3 Positively Modulates Hedgehog Signaling and Melanoma Growth., [RefSeq, PubMed]; GIPC3 couples to MYO6 and PDZ domain proteins, and shapes the hair cell apical region., [RefSeq, PubMed]; Gipc3 plays a pivotal role in acoustic signal acquisition and propagation in cochlear hair cells, while mutations are associated with audiogenic seizures and sensorineural hearing loss. Publication Status: Online-Only, [RefSeq, PubMed]; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion., [UniProtKB, PubMed]; The physiological significance of GIPC3 as a genetic interactor of BRCA2 is supported by the observation that Brca2-null embryos with Gipc3 overexpression are developmentally more advanced than their control littermates. Taken together, we have uncovered a novel role for GIPC3 as a BRCA2 genetic interactor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R5M0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XA2-1", "uniprot_id": "GOLM1_MOUSE", "mass": 44326.0, "length": 393, "protein_name": "Golgi membrane protein 1", "gene_name": "Golm1", "organism": "Mouse", "refseq_name": "Golgi membrane protein 1", "refseq_ac": "NP_001030294", "gene_names_uniprotkb": "Golm1; Golph2", "gene_names_refseq": "2310001L02Rik; D030064E01Rik; GP73; Golm1; Golph2; PSEC0257", "protein_names_uniprotkb": "Golgi membrane protein 1; Golgi membrane protein GP73; Golgi phosphoprotein 2", "protein_names_refseq": "Golgi membrane protein 1; golgi membrane protein GP73; golgi phosphoprotein 2", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); osteoporosis (Disease Ontology:DOID:11476); hepatitis (Disease Ontology:DOID:2237); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:105348); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;19349973;19596473;25428506;30084848;34428180;38029327;38459023;38459588;39239555", "class_list": "", "function": "Causal Association of Golgi Protein 73 With Coronary Artery Disease: Evidence from Proteomics and Mendelian Randomization. Publication Status: Online-Only, [RefSeq, PubMed]; Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress. Publication Status: Online-Only, [RefSeq, PubMed]; GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1., [RefSeq, PubMed]; In Atp7b(-/-) mice, GP73 mRNA was significantly elevated at 20-46 weeks of age, coincident with extensive hepatic inflammation and fibrosis., [RefSeq, PubMed]; PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1. Publication Status: Online-Only, [RefSeq, PubMed]; Unknown. Cellular response protein to viral infection., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3X8U4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0019216 regulation of lipid metabolic process;GO:0006997 nucleus organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q91XA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MT7-1", "uniprot_id": "GPR87_MOUSE", "mass": 41414.0, "length": 358, "protein_name": "G protein-coupled receptor 87", "gene_name": "Gpr87", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 87", "refseq_ac": "NP_001289132", "gene_names_uniprotkb": "Gpr87", "gene_names_refseq": "Gpr87", "protein_names_uniprotkb": "G protein-coupled receptor 87", "protein_names_refseq": "G-protein coupled receptor 87", "tax_id": 10090, "disease": "", "pathway": " (mmu:84111)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11273702;17905198;25428506;35843477", "class_list": "", "function": "GPR87 promotes renal tubulointerstitial fibrosis by accelerating glycolysis and mitochondrial injury., [RefSeq, PubMed]; Receptor for lysophosphatidic acid (LPA) (PubMed:17905198). Necessary for p53/TP53-dependent survival in response to DNA damage (By similarity). Promotes the Hippo-YAP signaling pathway and thereby modulates glycolysis and oxidative stress production by the regulation of hexokinase-2/HK2 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Results suggest that the GPR87 is a LPA receptor which evolved from a common ancestor of P2Y receptors., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4Y7", "ec_number_list": "", "go_molecular_function": "GO:0045028 G protein-coupled purinergic nucleotide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035329 hippo signaling;GO:0061621 canonical glycolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99MT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CRA5-1", "uniprot_id": "GOLP3_MOUSE", "mass": 33752.0, "length": 298, "protein_name": "Golgi phosphoprotein 3", "gene_name": "Golph3", "organism": "Mouse", "refseq_name": "Golgi phosphoprotein 3", "refseq_ac": "NP_079949", "gene_names_uniprotkb": "Golph3; Gpp34", "gene_names_refseq": "4733401N08Rik; 5730410D03Rik; Golph3", "protein_names_uniprotkb": "Golgi phosphoprotein 3; Coat protein GPP34", "protein_names_refseq": "Golgi phosphoprotein 3; coat protein GPP34", "tax_id": 10090, "disease": "", "pathway": " (mmu:66629)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17629635;21183079;23345592;25633094;29187903;34428180", "class_list": "", "function": "Golph3 is a target gene of miR34a. miR34a/GOLPH3 axis abrogates cancer cell stemness involved in urothelial bladder cancer chemoresistance. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis (By similarity)., [UniProtKB]; The current study found that GOLPH3, an outer membrane protein of the Golgi complex, was significantly upregulated in N2A cells upon oxygen-glucose deprivation and reoxygenation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6BLP3;Q99KY1;Q9D636", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0140312 cargo adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005768 endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0072752 cellular response to rapamycin;GO:0045053 protein retention in Golgi apparatus;GO:0090164 asymmetric Golgi ribbon formation;GO:0016477 cell migration;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CRA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CX99-1", "uniprot_id": "GRAP_MOUSE", "mass": 25277.0, "length": 217, "protein_name": "GRB2-related adapter protein", "gene_name": "Grap", "organism": "Mouse", "refseq_name": "GRB2-related adapter protein", "refseq_ac": "NP_082093", "gene_names_uniprotkb": "Grap", "gene_names_refseq": "8430435N19Rik; Grap", "protein_names_uniprotkb": "GRB2-related adapter protein", "protein_names_refseq": "GRB2-related adapter protein", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 114 (Disease Ontology:DOID:0111642)", "pathway": " (mmu:71520); (R-MMU-1433557)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11971956;15174222;15456754;19836472;30610177;37343720", "class_list": "", "function": "Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing., [UniProtKB, UniProtKB]; Data suggest that Grap, unlike Grb2, acts as a negative regulator of TCR-stimulated intracellular signaling by downregulating signal relay through the Ras/Erk pathway., [RefSeq, PubMed]; FcgammaRIIB docking site for the SH2 domain-containing adapters Grb2 and Grap, [RefSeq, PubMed]; Grb2-related adaptor protein (GRAP) was up-regulated in kidney tubules from diabetic mice, indicating a potential novel role for GRAP in TGF-beta-induced tubule injury in diabetic kidney disease., [RefSeq, PubMed]; Grb2-related adaptor protein GRAP is a novel regulator of liver fibrosis., [RefSeq, PubMed]; Results suggest that the GRAP gene might have a role in the pathogenesis of Sjogren's syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBE3;Q3U545", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0007165 signal transduction;GO:0007265 Ras protein signal transduction;GO:0007605 sensory perception of sound;GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CX99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1U0-1", "uniprot_id": "GRIFN_MOUSE", "mass": 15971.0, "length": 144, "protein_name": "Grifin", "gene_name": "Grifin", "organism": "Mouse", "refseq_name": "grifin", "refseq_ac": "NP_084298", "gene_names_uniprotkb": "Grifin", "gene_names_refseq": "E130101O17Rik; Grifin", "protein_names_uniprotkb": "Grifin; Galectin-related inter-fiber protein", "protein_names_refseq": "grifin", "tax_id": 10090, "disease": "", "pathway": " (mmu:77998)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "39627609", "class_list": "glycogene", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D1U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D428-1", "uniprot_id": "GOG7B_MOUSE", "mass": 18335.0, "length": 167, "protein_name": "Golgin subfamily A member 7B", "gene_name": "GOLGA7B", "organism": "Mouse", "refseq_name": "golgin subfamily A member 7B", "refseq_ac": "NP_001135455", "gene_names_uniprotkb": "GOLGA7B", "gene_names_refseq": "4933417O08Rik; Golga7b", "protein_names_uniprotkb": "Golgin subfamily A member 7B", "protein_names_refseq": "golgi autoantigen, golgin subfamily a, 7B; golgin subfamily A member 7B", "tax_id": 10090, "disease": "", "pathway": " (mmu:71146)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16452087", "class_list": "", "function": "Play a role in cell adhesion by regulating the plasma membrane localization of the palmitoyltransferase ZDHHC5. May be involved in protein transport from Golgi to cell surface., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8Y5D0;Q3UTK8", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0002178 palmitoyltransferase complex", "go_biological_process": "GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D428-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7M1-1", "uniprot_id": "GID8_MOUSE", "mass": 26779.0, "length": 228, "protein_name": "Glucose-induced degradation protein 8 homolog", "gene_name": "Gid8", "organism": "Mouse", "refseq_name": "glucose-induced degradation protein 8 homolog", "refseq_ac": "NP_001276580", "gene_names_uniprotkb": "Gid8", "gene_names_refseq": "2310003C23Rik; 4833420G11Rik; Gid8; Twa1", "protein_names_uniprotkb": "Glucose-induced degradation protein 8 homolog; Twa1; Two hybrid-associated protein 1 with RanBPM", "protein_names_refseq": "GID complex subunit 8 homolog; glucose-induced degradation protein 8 homolog; protein C20orf11 homolog; two hybrid-associated protein 1 with RanBPM", "tax_id": 10090, "disease": "", "pathway": " (mmu:76425); (R-MMU-9861718)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12559565;27920276", "class_list": "", "function": "CD spectroscopy of recombinant TWA1 indicated a predominantly alpha-helical protein. Gel filtration chromatography, size-exclusion chromatography (SEC) with multi-angle light scattering (SEC-MALS) and native PAGE demonstrated a propensity of untagged TWA1 to form stable dimers and, to a lesser extent, higher order oligomers. Publication Status: Online-Only, [RefSeq, PubMed]; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030054 cell junction", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D7M1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D964-1", "uniprot_id": "GATM_MOUSE", "mass": 48297.0, "length": 423, "protein_name": "Glycine amidinotransferase, mitochondrial", "gene_name": "Gatm", "organism": "Mouse", "refseq_name": "glycine amidinotransferase, mitochondrial precursor", "refseq_ac": "NP_080237", "gene_names_uniprotkb": "Gatm", "gene_names_refseq": "1810003P21Rik; AT; Gatm", "protein_names_uniprotkb": "Glycine amidinotransferase, mitochondrial; 2.1.4.1; L-arginine:glycine amidinotransferase; Transamidinase", "protein_names_refseq": "L-arginine:glycine amidinotransferase; glycine amidinotransferase, mitochondrial precursor; glycine amidinotransferase, mitochondrial; transamidinase", "tax_id": 10090, "disease": "AGAT deficiency (Disease Ontology:DOID:0050712); Fanconi renotubular syndrome 1 (Disease Ontology:DOID:0080757); pre-eclampsia (Disease Ontology:DOID:10591); acute kidney failure (Disease Ontology:DOID:3021); kidney disease (Disease Ontology:DOID:557); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:67092); (R-MMU-71288)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12671064;29654216", "class_list": "", "function": "Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives (By similarity). Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AK36;Q3U8U4;Q3UAM0;Q3UKD9;Q6IU01", "ec_number_list": "2.1.4.1", "go_molecular_function": "GO:0015067 amidinotransferase activity;GO:0015068 glycine amidinotransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:1905395 response to flavonoid;GO:0007584 response to nutrient;GO:0007611 learning or memory;GO:0001822 kidney development;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D964-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQQ3-1", "uniprot_id": "GPR63_MOUSE", "mass": 47788.0, "length": 425, "protein_name": "Probable G protein-coupled receptor 63", "gene_name": "Gpr63", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 63", "refseq_ac": "NP_109658", "gene_names_uniprotkb": "Gpr63", "gene_names_refseq": "Gpr63; PSP24beta; Psp24-2", "protein_names_uniprotkb": "Probable G protein-coupled receptor 63; PSP24-2; PSP24-beta", "protein_names_refseq": "G protein-coupled receptor PSP24-2; PSP24-beta; probable G-protein coupled receptor 63", "tax_id": 10090, "disease": "", "pathway": " (mmu:81006)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11027574;25428506;31730647", "class_list": "", "function": "Orphan receptor. May play a role in brain function., [UniProtKB]; This validated Gpr63 as a modifier of multiple Ttc21b neural phenotypes and strongly supports Gpr63 as a causal gene (i.e., a quantitative trait gene, QTG) within the Moaq1 QTL. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ93", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EQQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQX0-1", "uniprot_id": "GHRL_MOUSE", "mass": 13207.0, "length": 117, "protein_name": "Appetite-regulating hormone", "gene_name": "Ghrl", "organism": "Mouse", "refseq_name": "appetite-regulating hormone isoform 2 preproprotein", "refseq_ac": "NP_001273333", "gene_names_uniprotkb": "Ghrl; Mtlrp", "gene_names_refseq": "2210006E23Rik; Ghrl; Ghr; MTLRPAP; MTLRP; m46", "protein_names_uniprotkb": "Appetite-regulating hormone; Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; Protein M46", "protein_names_refseq": "appetite-regulating hormone isoform 2 preproprotein; appetite-regulating hormone; growth hormone secretagogue; growth hormone-releasing peptide; motilin-related peptide; preproghrelin; proghrelin", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); morbid obesity (Disease Ontology:DOID:11981); Prader-Willi syndrome (Disease Ontology:DOID:11983); cardiovascular system disease (Disease Ontology:DOID:1287); multiple endocrine neoplasia (Disease Ontology:DOID:3125); middle cerebral artery infarction (Disease Ontology:DOID:3525); esophagus adenocarcinoma (Disease Ontology:DOID:4914); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:58991); (R-MMU-416476); (R-MMU-422085)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10930375;11306336;12039068;15471962;15677766;15746259;17050541;17904104;18443287;21750661;39436864;39436995", "class_list": "", "function": "Coexpression of ghrelin and its receptor in murine tissues suggests varied autocrine/paracrine roles. Exon 4-deleted proghrelin is also widely expressed in the mouse and thus may possess biological activity in these tissues., [RefSeq, PubMed]; Ghrelin is involved in regulating the progression of Echinococcus Granulosus-infected liver lesions through suppression of immunoinflammation and fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (By similarity). Octanoylated ghrelin-28 is the most commonly found ghrelin and octanoylation is essential for the activation of the growth hormone secretagogue receptor type 1 (GHSR) (By similarity). Induces the release of growth hormone from the pituitary (By similarity). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation., [UniProtKB, UniProtKB]; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation., [UniProtKB, UniProtKB]; In mouse stomach, prohormone convertase 1/3 (PC1/3) is endoprotease responsible for the conversion of proghrelin to ghrelin; acylation of this peptide is processing-independent; expression of proghrelin mRNA is increased in processing-deficient mouse Erratum:[J Biol Chem. 2007 Jan 19;282(3):2124. Voodg, Keith [corrected to Voogd, Keith]], [RefSeq, PubMed]; Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice., [RefSeq, PubMed]; Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility., [UniProtKB, UniProtKB, UniProtKB]; Precursor of the appetite-regulating peptide ghrelin, including ghrelin-27 and ghrelin-28., [UniProtKB, UniProtKB]; Results support a role of ghrelin in growth/metabolism in juvenile and young adult mice of both sexes and in sexually dimorphic regulation of GH secretion in aged mice., [RefSeq, PubMed]; This gene encodes a preproprotein that undergoes proteolytic processing to yield two bioactive peptides, ghrelin and obestatin. The hormone ghrelin plays a role in enhancing appetite and has numerous other biological functions that include stimulating the secretion of growth hormone (somatotropin) from the anterior pituitary gland. Obestatin is thought to be a hormone that functions in decreasing appetite. Mice lacking the encoded protein develop normally and exhibit no gross anatomical abnormalities. This gene encodes distinct isoforms, some or all of which may undergo similar proteolytic processing. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUZ1", "ec_number_list": "", "go_molecular_function": "GO:0031768 ghrelin receptor binding;GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity;GO:0030296 protein tyrosine kinase activator activity;GO:0016608 growth hormone-releasing hormone activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0032095 regulation of response to food;GO:0032100 positive regulation of appetite;GO:0120058 positive regulation of small intestinal transit;GO:1903012 positive regulation of bone development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9EQX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIL6-1", "uniprot_id": "GPC5D_MOUSE", "mass": 39056.0, "length": 344, "protein_name": "G protein-coupled receptor family C group 5 member D", "gene_name": "Gprc5d", "organism": "Mouse", "refseq_name": "G-protein coupled receptor family C group 5 member D isoform 1", "refseq_ac": "NP_001192325", "gene_names_uniprotkb": "Gprc5d", "gene_names_refseq": "Gprc5d", "protein_names_uniprotkb": "G protein-coupled receptor family C group 5 member D", "protein_names_refseq": "G-protein coupled receptor family C group 5 member D isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:93746)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11311935;15086536", "class_list": "", "function": "G protein-coupled receptor involved in hard keratin expression and likely plays a role in the development of hair and nails., [UniProtKB, PubMed]; GPRC5D is involed in the regulation of keratin synthesis in hard epithelial tissue., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CJI0;Q8CJI1", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0070062 extracellular exosome", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0031424 keratinization;GO:0042633 hair cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JIL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJT2-1", "uniprot_id": "GFRA4_MOUSE", "mass": 27990.0, "length": 260, "protein_name": "GDNF family receptor alpha-4", "gene_name": "Gfra4", "organism": "Mouse", "refseq_name": "GDNF family receptor alpha-4 isoform 1 precursor", "refseq_ac": "NP_001129535", "gene_names_uniprotkb": "Gfra4", "gene_names_refseq": "G630015H18Rik; Gfra4", "protein_names_uniprotkb": "GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR-alpha-4; Persephin receptor", "protein_names_refseq": "GDNF family receptor alpha-4 isoform 1 precursor; GDNF family receptor alpha-4; GDNFR-alpha-4; GFR alpha-4; persephin receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14588); (R-MMU-5673001); (R-MMU-8853659)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10860579;16497798", "class_list": "", "function": "GFRalpha4 signaling has a role in regulating calcitonin production in thyroid C cells of young mice, [RefSeq, PubMed]; Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla., [UniProtKB, UniProtKB]; This gene encodes a transmembrane protein that functions as the receptor for persephin, a member of the glial cell line derived neurotrophic factors. The encoded protein undergoes proteolytic processing to generate a glycosylphosphatidylinositol-anchored cell surface coreceptor that forms a complex with the receptor tyrosine kinase Ret. A complete lack of the encoded protein impairs production of thyroid calcitonin and increases the rate of bone formation in young mice. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AP44;A2AP46;A2AP47;A2AP49;Q9JJT3;Q9JJT4;Q9JJT6;Q9JJT7;Q9JJT8", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0016167 glial cell-derived neurotrophic factor receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0030279 negative regulation of ossification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QY42-1", "uniprot_id": "GPR37_MOUSE", "mass": 66775.0, "length": 600, "protein_name": "Prosaposin receptor GPR37", "gene_name": "Gpr37", "organism": "Mouse", "refseq_name": "prosaposin receptor GPR37 precursor", "refseq_ac": "NP_034468", "gene_names_uniprotkb": "Gpr37", "gene_names_refseq": "Gpr37; Pael-R", "protein_names_uniprotkb": "Prosaposin receptor GPR37; G protein-coupled receptor 37", "protein_names_refseq": "parkin-associated endothelin B-like receptor; probable G-protein coupled receptor 37; prosaposin receptor GPR37 precursor; prosaposin receptor GPR37", "tax_id": 10090, "disease": "Lewy body dementia (Disease Ontology:DOID:12217); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:14763); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17116640;26961174;28642167;30010619;33731716;34678058;37436891;37749229;9799598", "class_list": "", "function": "G protein-coupled receptor that plays a role in several physiological pathways such as resolution of inflammatory pain and oligodendrocyte differentiation (PubMed:26961174, PubMed:28642167, PubMed:30010619). Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity). Acts as a receptor for osteocalcin (OCN) to regulate oligodendrocyte differentiation and central nervous system myelination (PubMed:34678058). Mechanistically, plays a negative role in oligodendrocyte differentiation and myelination during development via activation of the ERK1/2 signaling pathway (PubMed:26961174). Therefore, regulates the stability of myelin or resistance of myelin itself to demyelination (PubMed:28642167). Upon activation by neuroprotectin D1 (NPD1), promotes the activation of phagocytosis in macrophages as well as the shift in cytokine release toward an anti-inflammatory profile, and thus helps to reverse inflammatory pain (PubMed:30010619). In addition, the increased macrophage phagocytosis mediates protection against sepsis upon pathogen infection (PubMed:33731716). Additionally, extracellular vesicles derived from efferocyte express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor TIM4 via an ERK-AP1-dependent signaling axis, leading to increased macrophage efferocytosis efficiency and accelerated resolution of inflammation (PubMed:37436891). May also act as a maturation factor of LRP6, protecting LRP6 from the endoplasmic reticulum (ER)-associated protein degradation (ERAD) and thereby promoting the Wnt/beta-catenin signaling pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway., [RefSeq, PubMed]; Upregulation of Pael-R in the substantia nigra pars compacta of mice by retrograde infection induced endoplasmic reticulum (ER) stress leads to death of dopaminergic neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKF8;Q8BXP9;Q8C022;Q9Z0G3", "ec_number_list": "", "go_molecular_function": "GO:0036505 prosaposin receptor activity;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0030165 PDZ domain binding;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0016358 dendrite development;GO:0043410 positive regulation of MAPK cascade;GO:0031987 locomotion involved in locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9QY42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ES90-1", "uniprot_id": "GPR35_MOUSE", "mass": 34152.0, "length": 307, "protein_name": "G protein-coupled receptor 35", "gene_name": "Gpr35", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 35", "refseq_ac": "NP_001097999", "gene_names_uniprotkb": "Gpr35", "gene_names_refseq": "Gpr35; KPG_007", "protein_names_uniprotkb": "G protein-coupled receptor 35; KYNA receptor; Kynurenic acid receptor", "protein_names_refseq": "G-protein coupled receptor 35; KYNA receptor; kynurenic acid receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:64095); (R-MMU-373076)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11017071;16754668;21750661;24095869;26495903;29414686;32755573;34428180;35926043;38198925", "class_list": "", "function": "A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior., [RefSeq, PubMed]; Cardiac expression of GPR35 is regulated by hypoxia through activation of HIF-1., [RefSeq, PubMed]; G protein-coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:16754668, PubMed:29414686, PubMed:32755573). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). GPR35 can couple with G(i)/G(o)- or G(12)/G(13) classes of G alpha proteins depending on the context, mediating the inhibition of adenylate cyclase or activation Rho small GTPases, respectively (By similarity). KYNA-binding promotes monocyte adhesion to vascular endothelium under flow conditions, leading to G(i)/GNAI1 activation and inhibition of adenylate cyclase (By similarity). Involved in cardioprotection during ischemia by promoting mitochondrial remodeling: following KYNA-binding and G(i)/GNAI1 activation, GPR35 is internalized to the outer mitochondrial membrane, where it inhibits mitochondrial adenylate cyclase (ADCY10), allowing ATPIF1 to repress ATP synthase activity (PubMed:35926043). Stimulates lipid metabolism, thermogenic and anti-inflammatory gene expression in adipose tissue once activated by KYNA (PubMed:29414686). Plays a role in neutrophil recruitment to sites of inflammation and bacterial clearance through the major serotonin metabolite 5-HIAA that acts as a physiological ligand (By similarity). In macrophages, activation by lysophosphatidic acid promotes GPR35-induced signaling with a distinct transcriptional profile characterized by TNF production associated with ERK and NF-kappa-B activation (PubMed:32755573). In turn, induces chemotaxis of macrophages (PubMed:32755573)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016494 C-X-C chemokine receptor activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002931 response to ischemia;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0070098 chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9ES90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20612-1", "uniprot_id": "GNAT1_MOUSE", "mass": 39967.0, "length": 350, "protein_name": "Guanine nucleotide-binding protein G(t) subunit alpha-1", "gene_name": "Gnat1", "organism": "Mouse", "refseq_name": "guanine nucleotide-binding protein G(t) subunit alpha-1", "refseq_ac": "NP_032166", "gene_names_uniprotkb": "Gnat1; Gnat-1", "gene_names_refseq": "Gnat-1; Gnat1; Hg1f; Ird1; Ird2; Tralpha; irdc; irdr; transducin", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(t) subunit alpha-1; 3.6.5.-; Transducin alpha-1 chain", "protein_names_refseq": "guanine nucleotide binding protein, alpha transducing 1; guanine nucleotide-binding protein G(t) subunit alpha-1; heterotrimeric guanine nucleotide-binding protein 1f; transducin alpha-1 chain", "tax_id": 10090, "disease": "congenital stationary night blindness 1G (Disease Ontology:DOID:0110714); congenital stationary night blindness autosomal dominant 3 (Disease Ontology:DOID:0110715); McCune Albright syndrome (Disease Ontology:DOID:1858); night blindness (Disease Ontology:DOID:8499)", "pathway": " (mmu:14685); (R-MMU-2485179); (R-MMU-2514859); (R-MMU-418594)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "21750661;2708360;31696965;8858601", "class_list": "", "function": "Alpha subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) that transduces signals from the G protein-coupled photoreceptor rhodopsin (RHO). Required for normal RHO-mediated light perception in retinal rod photoreceptors (By similarity). Functions as a GTPase that contains the guanine nucleotide binding site and cycles between an active GTP-bound state and an inactive GDP-bound state. Under dim light conditions, RHO promotes GDP release and GTP binding. Activates downstream effectors, including cone cGMP-phosphodiesterase (PDE6), to mediate the phototransduction cascade (By similarity). Stimulates PDE6 by binding and repositioning the PDE6 gamma inhibitory subunits (PDE6G) to promote catalytic activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80X34", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.4.11.18;3.6.1.5;2.3.1.97;3.6.5.4;3.1.4.35;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0016324 apical plasma membrane;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0009583 detection of light stimulus;GO:0007186 G protein-coupled receptor signaling pathway;GO:0008283 cell population proliferation;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20612-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1B213-1", "uniprot_id": "H60C_MOUSE", "mass": 22340.0, "length": 197, "protein_name": "Histocompatibility antigen 60c", "gene_name": "H60c", "organism": "Mouse", "refseq_name": "histocompatibility antigen 60c precursor", "refseq_ac": "NP_001191845", "gene_names_uniprotkb": "H60c", "gene_names_refseq": "4632413I24Rik; 670558; Gm9491; H60c", "protein_names_uniprotkb": "Histocompatibility antigen 60c", "protein_names_refseq": "histocompatibility antigen 60c precursor; histocompatibility antigen 60c", "tax_id": 10090, "disease": "", "pathway": " (mmu:670558)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18209064;21750661;22403443", "class_list": "", "function": "A more general role for H60c in the maintenance of epithelial integrity., [RefSeq, PubMed]; Identified two novel mouse chromosome 10-encoded NKG2D ligands, H60b and H60c, structurally resembling H60., [RefSeq, PubMed]; Ligand for the KLRK1 immunosurveillance receptor. Binding to KLRK1 stimulates cell lysis in vitro., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0042267 natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B1B213-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQP0-1", "uniprot_id": "GP141_MOUSE", "mass": 35284.0, "length": 305, "protein_name": "Probable G protein-coupled receptor 141", "gene_name": "Gpr141", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 141", "refseq_ac": "NP_861419", "gene_names_uniprotkb": "Gpr141; Pgr13", "gene_names_refseq": "Gpr141; PGR13", "protein_names_uniprotkb": "Probable G protein-coupled receptor 141; G protein-coupled receptor PGR13", "protein_names_refseq": "G-protein coupled receptor PGR13; probable G-protein coupled receptor 141", "tax_id": 10090, "disease": "", "pathway": " (mmu:353346)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12679517;14623098;21750661;25428506;30084848;38226682", "class_list": "", "function": "Orphan receptor., [UniProtKB]; The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q059N8;Q80UC5", "ec_number_list": "", "go_molecular_function": "GO:0008142 oxysterol binding;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TQP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0Z9-1", "uniprot_id": "GP153_MOUSE", "mass": 68459.0, "length": 631, "protein_name": "Probable G protein-coupled receptor 153", "gene_name": "Gpr153", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 153 isoform 1", "refseq_ac": "NP_848493", "gene_names_uniprotkb": "Gpr153; Pgr1", "gene_names_refseq": "1110065N12Rik; Gpr153; PGR1", "protein_names_uniprotkb": "Probable G protein-coupled receptor 153; G protein-coupled receptor PGR1", "protein_names_refseq": "G protein-coupled receptor PGR1; probable G-protein coupled receptor 153 isoform 1; probable G-protein coupled receptor 153", "tax_id": 10090, "disease": "", "pathway": " (mmu:100129)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12679517;21750661;25428506", "class_list": "", "function": "Orphan receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80T37;Q8CFK0", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K0Z9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35166-1", "uniprot_id": "GOSR2_MOUSE", "mass": 24725.0, "length": 212, "protein_name": "Golgi SNAP receptor complex member 2", "gene_name": "Gosr2", "organism": "Mouse", "refseq_name": "Golgi SNAP receptor complex member 2 isoform 1", "refseq_ac": "NP_062624", "gene_names_uniprotkb": "Gosr2; Gs27", "gene_names_refseq": "2310032N09Rik; Gosr2; Gs27; SNARE; membrin", "protein_names_uniprotkb": "Golgi SNAP receptor complex member 2; 27 kDa Golgi SNARE protein; Membrin", "protein_names_refseq": "27 kDa Golgi SNARE protein; Golgi SNAP receptor complex member 2 isoform 1; golgi SNARE", "tax_id": 10090, "disease": "progressive myoclonus epilepsy 6 (Disease Ontology:DOID:0111449); progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (mmu:56494); (R-MMU-204005); (R-MMU-5694530); (R-MMU-6807878); (R-MMU-6811438)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "21750661;28978487;31219806;34203471;34428180;9349823", "class_list": "", "function": "Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mutations in GOSR2 reveal stringent secretory pathway demands of dendritic growth and synaptic integrity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDN0;Q9CR77", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0006906 vesicle fusion;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35166-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGT9-1", "uniprot_id": "GLT12_MOUSE", "mass": 66541.0, "length": 576, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 12", "gene_name": "Galnt12", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 12", "refseq_ac": "NP_766281", "gene_names_uniprotkb": "Galnt12", "gene_names_refseq": "9130206E10; A630062B03Rik; Galnt12; galNAc-T12; mpp-GalNAc-T12; pp-GaNTase 12; pp-GaNTase", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 12; 2.4.1.41; GalNAc-T12; Polypeptide GalNAc transferase 12; Protein-UDP acetylgalactosaminyltransferase 12; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12; pp-GaNTase 12", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12; polypeptide GalNAc transferase 12; polypeptide N-acetylgalactosaminyltransferase 12; protein-UDP acetylgalactosaminyltransferase 12", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:230145); (R-MMU-913709)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;25428506;26495903;30084848;30779550;32152506", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 0.7, "record_id": "Q8BGT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C6A1-1", "uniprot_id": "GTR7_MOUSE", "mass": 55886.0, "length": 513, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 7", "gene_name": "Slc2a7", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Slc2a7", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 7; GLUT-7; Glucose transporter type 7", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:435818); (R-MMU-189200)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "glycogene", "function": "Probable sugar transporter. Even if its physiological substrate is subject to discussion, it is able to transport glucose and fructose. Does not transport galactose, 2-deoxy-d-glucose and xylose., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 9906, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0015755 fructose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0C6A1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFZ4-1", "uniprot_id": "GPC3_MOUSE", "mass": 65332.0, "length": 579, "protein_name": "Glypican-3", "gene_name": "Gpc3", "organism": "Mouse", "refseq_name": "glypican-3 precursor", "refseq_ac": "NP_057906", "gene_names_uniprotkb": "Gpc3", "gene_names_refseq": "Gpc3; OCI-5", "protein_names_uniprotkb": "Glypican-3", "protein_names_refseq": "glypican-3 precursor", "tax_id": 10090, "disease": "Simpson-Golabi-Behmel syndrome type 1 (Disease Ontology:DOID:0060248); atypical teratoid rhabdoid tumor (Disease Ontology:DOID:2129); nephroblastoma (Disease Ontology:DOID:2154); placental site trophoblastic tumor (Disease Ontology:DOID:3596); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687)", "pathway": " (mmu:14734); (R-MMU-1971475); (R-MMU-2022928); (R-MMU-2024096); (R-MMU-381426); (R-MMU-8957275); (R-MMU-975634); (R-MMU-9769735); (R-MMU-9769739)", "pathway_count": 9, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10402475;10964473;11180950;15537637;18477453;19733558;21750661;23665349;30084848;31219806;34428180", "class_list": "glycogene", "function": "Cell surface proteoglycan (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (PubMed:18477453, PubMed:23665349). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (PubMed:18477453). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (By similarity). Positively regulates the non-canonical Wnt signaling pathway (PubMed:15537637). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (PubMed:23665349). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (PubMed:10964473). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (PubMed:11180950). Required for coronary vascular development (PubMed:19733558). Plays a role in regulating cell movements during gastrulation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Cell surface proteoglycan., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 35, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060422 peptidyl-dipeptidase inhibitor activity", "go_cellular_component": "GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0005764 lysosome", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0045880 positive regulation of smoothened signaling pathway;GO:0010171 body morphogenesis;GO:0072180 mesonephric duct morphogenesis;GO:0072203 cell proliferation involved in metanephros development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CFZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35413-1", "uniprot_id": "GPR3_MOUSE", "mass": 35453.0, "length": 330, "protein_name": "G protein-coupled receptor 3", "gene_name": "Gpr3", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 3", "refseq_ac": "NP_032180", "gene_names_uniprotkb": "Gpr3; Gpcr3", "gene_names_refseq": "Gpcr20; Gpcr21; Gpcr3; Gpr3", "protein_names_uniprotkb": "G protein-coupled receptor 3; GPCR21", "protein_names_refseq": "G-protein coupled receptor 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:14748)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15591206;15956199;16229830;19259266;21750661;26455425;34048700;34871769;35809764;36161942;8262253", "class_list": "", "function": "Constitutively active G protein-coupled receptor that maintains high cAMP levels and contributes to several processes, including meiotic arrest in oocytes and neuronal development, through activation of intracellular signaling pathways (PubMed:15956199, PubMed:19259266). Essential activator of thermogenic adipocytes, where it drives thermogenesis via constitutive G(s)-coupling activity in the absence of ligand (PubMed:26455425, PubMed:34048700). May be activated by lipid-derived agonists such as oleoylethanolamide (OEA), oleic acid or sphingosine 1-phosphate leading to activation of the G(s)/cAMP/PKA signaling pathway (By similarity). Plays a potential role in modulating brain functions, including behavioral responses to stress and amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granule neurons via PKA, ERK, and PI3K-mediated signaling pathways (PubMed:34871769)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model., [RefSeq, PubMed]; GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice., [RefSeq, PubMed]; Gpr3-defective mice may constitute a relevant model of premature ovarian failure due to early oocyte aging., [RefSeq, PubMed]; The GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle and is crucial for the regulation of meiosis, [RefSeq, PubMed]; The cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3USD4", "ec_number_list": "", "go_molecular_function": "GO:0038036 sphingosine-1-phosphate receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0040020 regulation of meiotic nuclear division;GO:0120162 positive regulation of cold-induced thermogenesis;GO:0141163 positive regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P35413-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HKE4-1", "uniprot_id": "H2A1E_MOUSE", "mass": 14135.0, "length": 130, "protein_name": "Histone H2A type 1-E", "gene_name": "H2ac8", "organism": "Mouse", "refseq_name": "histone H2A type 1-E", "refseq_ac": "NP_835494", "gene_names_uniprotkb": "H2ac8; Hist1h2ae", "gene_names_refseq": "1190022L06; H2ac8; Hist1h2ae", "protein_names_uniprotkb": "Histone H2A type 1-E", "protein_names_refseq": "histone 1, H2ae; histone H2A type 1-E; histone H2A type 1; histone cluster 1, H2ae", "tax_id": 10090, "disease": "", "pathway": " (mmu:319164); (mmu:319165); (mmu:319166); (mmu:319167); (mmu:319170); (mmu:319171); (mmu:319172); (mmu:319191); (mmu:665433); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 26, "publication_count": 10, "publication_id_list": "12408966;15509584;15525528;16699504;21925322;24352239;24681537;27105115;30154464;7217105", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10812;P22752;Q149U0;Q5SZZ2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "C0HKE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HKE6-1", "uniprot_id": "H2A1I_MOUSE", "mass": 14135.0, "length": 130, "protein_name": "Histone H2A type 1-I", "gene_name": "H2ac13", "organism": "Mouse", "refseq_name": "histone H2A type 1-I", "refseq_ac": "NP_835489", "gene_names_uniprotkb": "H2ac13; Hist1h2ai", "gene_names_refseq": "H2a-291A; H2ac13; Hist1h2ai", "protein_names_uniprotkb": "Histone H2A type 1-I", "protein_names_refseq": "histone 1, H2ai; histone 2, H2ai; histone H2A type 1-I; histone H2A type 1; histone cluster 1, H2ai", "tax_id": 10090, "disease": "", "pathway": " (mmu:319164); (mmu:319165); (mmu:319166); (mmu:319167); (mmu:319170); (mmu:319171); (mmu:319172); (mmu:319191); (mmu:665433); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 26, "publication_count": 11, "publication_id_list": "12408966;15509584;15525528;16699504;21925322;24352239;24681537;27105115;30154464;3562244;7217105", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10812;P22752;Q149U0;Q5SZZ2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "C0HKE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HKE9-1", "uniprot_id": "H2A1P_MOUSE", "mass": 14135.0, "length": 130, "protein_name": "Histone H2A type 1-P", "gene_name": "Hist1h2ap", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Hist1h2ap", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H2A type 1-P", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:319164); (mmu:319165); (mmu:319166); (mmu:319167); (mmu:319170); (mmu:319171); (mmu:319172); (mmu:319191); (mmu:665433); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 26, "publication_count": 9, "publication_id_list": "15509584;15525528;16699504;21925322;24352239;24681537;27105115;30154464;7217105", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10812;P22752;Q149U0;Q5SZZ2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "C0HKE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15626-1", "uniprot_id": "GSTM2_MOUSE", "mass": 25717.0, "length": 218, "protein_name": "Glutathione S-transferase Mu 2", "gene_name": "Gstm2", "organism": "Mouse", "refseq_name": "glutathione S-transferase Mu 2", "refseq_ac": "NP_032209", "gene_names_uniprotkb": "Gstm2", "gene_names_refseq": "Gstb-2; Gstb2; Gstm2", "protein_names_uniprotkb": "Glutathione S-transferase Mu 2; 2.5.1.18; GST 5-5; GST class-mu 2; Glutathione S-transferase pmGT2", "protein_names_refseq": "GST 5-5; GST class-mu 2; glutathione S-transferase Mu 2; glutathione S-transferase pmGT2", "tax_id": 10090, "disease": "pterygium (Disease Ontology:DOID:0002116); Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); inflammatory bowel disease (Disease Ontology:DOID:0050589); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); stroke (Disease Ontology:DOID:0051061); pre-malignant neoplasm (Disease Ontology:DOID:0060071); drug allergy (Disease Ontology:DOID:0060500); alcohol-associated liver disease (Disease Ontology:DOID:0070658); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); colorectal carcinoma (Disease Ontology:DOID:0080199); erythema nodosum (Disease Ontology:DOID:0080750); graft-versus-host disease (Disease Ontology:DOID:0081267); osteonecrosis (Disease Ontology:DOID:10159); thalassemia (Disease Ontology:DOID:10241); prostate cancer (Disease Ontology:DOID:10283); asbestosis (Disease Ontology:DOID:10320); lymphoid leukemia (Disease Ontology:DOID:1037); esophageal atresia (Disease Ontology:DOID:10485); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); head and neck cancer (Disease Ontology:DOID:11934); allergic disease (Disease Ontology:DOID:1205); optic neuritis (Disease Ontology:DOID:1210); aplastic anemia (Disease Ontology:DOID:12449); autistic disorder (Disease Ontology:DOID:12849); uterine fibroid (Disease Ontology:DOID:13223); lung cancer (Disease Ontology:DOID:1324); angle-closure glaucoma (Disease Ontology:DOID:13550); Fanconi anemia (Disease Ontology:DOID:13636); exfoliation syndrome (Disease Ontology:DOID:13641); Parkinson's disease (Disease Ontology:DOID:14330); aggressive periodontitis (Disease Ontology:DOID:1474); cystic fibrosis (Disease Ontology:DOID:1485); urticaria (Disease Ontology:DOID:1555); acute chest syndrome (Disease Ontology:DOID:1584); keratosis (Disease Ontology:DOID:161); breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682); malignant mesothelioma (Disease Ontology:DOID:1790); ovary epithelial cancer (Disease Ontology:DOID:2152); multiple sclerosis (Disease Ontology:DOID:2377); larynx cancer (Disease Ontology:DOID:2596); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); cervix carcinoma (Disease Ontology:DOID:2893); pulmonary tuberculosis (Disease Ontology:DOID:2957); adenocarcinoma (Disease Ontology:DOID:299); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gallbladder cancer (Disease Ontology:DOID:3121); porphyria cutanea tarda (Disease Ontology:DOID:3132); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); toxic encephalopathy (Disease Ontology:DOID:3602); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); gastritis (Disease Ontology:DOID:4029); systemic scleroderma (Disease Ontology:DOID:418); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); movement disease (Disease Ontology:DOID:480); small intestine adenocarcinoma (Disease Ontology:DOID:4906); esophagus adenocarcinoma (Disease Ontology:DOID:4914); cholangiocarcinoma (Disease Ontology:DOID:4947); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); oral submucous fibrosis (Disease Ontology:DOID:5773); leukopenia (Disease Ontology:DOID:615); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); Hodgkin's lymphoma (Disease Ontology:DOID:8567); infectious mononucleosis (Disease Ontology:DOID:8568); ulcerative colitis (Disease Ontology:DOID:8577); oral cavity cancer (Disease Ontology:DOID:8618); myeloid leukemia (Disease Ontology:DOID:8692); Crohn's disease (Disease Ontology:DOID:8778); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); polycythemia vera (Disease Ontology:DOID:8997); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14863); (R-MMU-156590)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11404019;18692819;21183079;21750661;2689439;32574561;34428180;36288343;8442656", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers., [UniProtKB, UniProtKB]; Gstm2 is highly expressed in the uterine luminal epithelium during preimplantation period and up-regulated by progesterone., [RefSeq, PubMed]; Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 112, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0051122 hepoxilin biosynthetic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P15626-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64471-1", "uniprot_id": "GSTT1_MOUSE", "mass": 27374.0, "length": 240, "protein_name": "Glutathione S-transferase theta-1", "gene_name": "Gstt1", "organism": "Mouse", "refseq_name": "glutathione S-transferase theta-1 isoform 1", "refseq_ac": "NP_032211", "gene_names_uniprotkb": "Gstt1", "gene_names_refseq": "Gstt1-1; Gstt1", "protein_names_uniprotkb": "Glutathione S-transferase theta-1; 2.5.1.18; GST class-theta-1", "protein_names_refseq": "GST class-theta-1; glutathione S-transferase theta-1 isoform 1", "tax_id": 10090, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); inflammatory bowel disease (Disease Ontology:DOID:0050589); alcohol dependence (Disease Ontology:DOID:0050741); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); drug allergy (Disease Ontology:DOID:0060500); alcohol-associated liver disease (Disease Ontology:DOID:0070658); mucositis (Disease Ontology:DOID:0080178); colorectal carcinoma (Disease Ontology:DOID:0080199); COVID-19 (Disease Ontology:DOID:0080600); venous insufficiency (Disease Ontology:DOID:10128); osteonecrosis (Disease Ontology:DOID:10159); prostate cancer (Disease Ontology:DOID:10283); lymphoid leukemia (Disease Ontology:DOID:1037); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypospadias (Disease Ontology:DOID:10892); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); head and neck cancer (Disease Ontology:DOID:11934); optic neuritis (Disease Ontology:DOID:1210); beta thalassemia (Disease Ontology:DOID:12241); neutropenia (Disease Ontology:DOID:1227); aplastic anemia (Disease Ontology:DOID:12449); cardiovascular system disease (Disease Ontology:DOID:1287); lung cancer (Disease Ontology:DOID:1324); Fanconi anemia (Disease Ontology:DOID:13636); exfoliation syndrome (Disease Ontology:DOID:13641); Parkinson's disease (Disease Ontology:DOID:14330); aggressive periodontitis (Disease Ontology:DOID:1474); cystic fibrosis (Disease Ontology:DOID:1485); acute chest syndrome (Disease Ontology:DOID:1584); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); ovary epithelial cancer (Disease Ontology:DOID:2152); motor neuron disease (Disease Ontology:DOID:231); colon adenocarcinoma (Disease Ontology:DOID:234); anemia (Disease Ontology:DOID:2355); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); cervix carcinoma (Disease Ontology:DOID:2893); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); liver disease (Disease Ontology:DOID:409); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); peripheral nervous system disease (Disease Ontology:DOID:574); oral submucous fibrosis (Disease Ontology:DOID:5773); leukopenia (Disease Ontology:DOID:615); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); Hodgkin's lymphoma (Disease Ontology:DOID:8567); infectious mononucleosis (Disease Ontology:DOID:8568); ulcerative colitis (Disease Ontology:DOID:8577); oral cavity cancer (Disease Ontology:DOID:8618); myeloid leukemia (Disease Ontology:DOID:8692); Crohn's disease (Disease Ontology:DOID:8778); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14871); (R-MMU-156590); (R-MMU-9753281)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11884241;20097269;21750661;34428180;35621716;37453647;37828378;8761485", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity., [UniProtKB, PubMed]; Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice., [RefSeq, PubMed]; The carcinogenic effects of DCM in the mouse are caused by the interaction with DNA of a glutathione (GSH) conjugate that is produced by the class theta glutathione S-transferase T1-1 (GST T1-1)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 92, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91X50", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004602 glutathione peroxidase activity;GO:0047651 alkylhalidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0033197 response to vitamin E;GO:0010269 response to selenium ion;GO:0009751 response to salicylic acid;GO:0006304 DNA modification;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64471-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NVG7-1", "uniprot_id": "GT252_MOUSE", "mass": 72788.0, "length": 625, "protein_name": "Procollagen galactosyltransferase 2", "gene_name": "Colgalt2", "organism": "Mouse", "refseq_name": "procollagen galactosyltransferase 2 isoform 1 precursor", "refseq_ac": "NP_808424", "gene_names_uniprotkb": "Colgalt2; Glt25d2", "gene_names_refseq": "Colgalt2; D730024P12; Glt25d2", "protein_names_uniprotkb": "Procollagen galactosyltransferase 2; 2.4.1.50; Collagen beta(1-O)galactosyltransferase 2; Glycosyltransferase 25 family member 2; Hydroxylysine galactosyltransferase 2", "protein_names_refseq": "glycosyltransferase 25 domain containing 2; glycosyltransferase 25 family member 2; hydroxylysine galactosyltransferase 2; procollagen galactosyltransferase 2 isoform 1 precursor; procollagen galactosyltransferase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:269132); (R-MMU-1650814)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "glycogene;glycosyltransferase", "function": "Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWD4", "ec_number_list": "2.4.1.50;1.14.11.4;2.4.1.66", "go_molecular_function": "GO:0050211 procollagen galactosyltransferase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0008283 cell population proliferation;GO:0070231 T cell apoptotic process;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6NVG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BS95-1", "uniprot_id": "GPHR_MOUSE", "mass": 52735.0, "length": 455, "protein_name": "Golgi pH regulator", "gene_name": "Gphr; Gpr89", "organism": "Mouse", "refseq_name": "Golgi pH regulator isoform 1", "refseq_ac": "NP_080505", "gene_names_uniprotkb": "Gphr; Gpr89; Gpr89a; Gpr89", "gene_names_refseq": "4933412D19Rik; Gphr; Gpr89a; Gpr89; SH120", "protein_names_uniprotkb": "Golgi pH regulator; Protein GPR89", "protein_names_refseq": "G protein-coupled receptor 89; Golgi pH regulator isoform 1; protein GPR89", "tax_id": 10090, "disease": "", "pathway": " (mmu:67549)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;31118204;32220963;34428180;35820727;36056653", "class_list": "", "function": "These results indicate that GPHR-dependent Golgi luminal acidification plays an essential role in the structural and functional maintenance of purkinje cells and basket cells. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-gated channel that enables the transfer of monoatomic anions such as iodide, chloride, bromide and fluoride which may function in counter-ion conductance and participates in Golgi acidification (By similarity). Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (PubMed:32220963). Essential for maintaining the acidic luminal pH of the Golgi apparatus in neurons, which is important for preserving Golgi structural integrity (PubMed:31118204, PubMed:36056653). This integrity supports proper axonal transport and synaptic maintenance in cerebellar inhibitory neurons, including Purkinje and basket cells (PubMed:31118204). Additionally, Golgi acidification facilitates the activation of SREBP2, thereby ensuring sufficient cholesterol biosynthesis necessary for normal neuronal morphology and function (PubMed:36056653)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9D455", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0008308 voltage-gated monoatomic anion channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0032580 Golgi cisterna membrane;GO:0034702 monoatomic ion channel complex;GO:0030660 Golgi-associated vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0043588 skin development;GO:0030217 T cell differentiation;GO:0051452 intracellular pH reduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BS95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4P7-1", "uniprot_id": "GSTT4_MOUSE", "mass": 28099.0, "length": 240, "protein_name": "Glutathione S-transferase theta-4", "gene_name": "Gstt4", "organism": "Mouse", "refseq_name": "glutathione S-transferase theta-4", "refseq_ac": "NP_083748", "gene_names_uniprotkb": "Gstt4", "gene_names_refseq": "4930583C14Rik; Gstt4", "protein_names_uniprotkb": "Glutathione S-transferase theta-4; 2.5.1.18; GST class-theta-4", "protein_names_refseq": "GST class-theta-4; glutathione S-transferase theta-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:75886)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D4P7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VBV8-1", "uniprot_id": "GUC1B_MOUSE", "mass": 23520.0, "length": 201, "protein_name": "Guanylyl cyclase-activating protein 2", "gene_name": "Guca1b", "organism": "Mouse", "refseq_name": "guanylyl cyclase-activating protein 2", "refseq_ac": "NP_666191", "gene_names_uniprotkb": "Guca1b", "gene_names_refseq": "GCAP2; Guca1b", "protein_names_uniprotkb": "Guanylyl cyclase-activating protein 2; GCAP 2; Guanylate cyclase activator 1B", "protein_names_refseq": "GCAP2 (retina); guanylyl cyclase-activating protein 2", "tax_id": 10090, "disease": "retinitis pigmentosa 48 (Disease Ontology:DOID:0110382)", "pathway": " (mmu:107477); (R-MMU-2514859)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15961391;21750661;22299025;25673692;29435986;31980596;9620085", "class_list": "", "function": "GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress. Publication Status: Online-Only, [RefSeq, PubMed]; Stimulates two retinal guanylyl cyclase (GCs) GUCY2E and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2E and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (PubMed:25673692)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030249 guanylate cyclase regulator activity;GO:0008048 calcium sensitive guanylate cyclase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0031965 nuclear membrane;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0007601 visual perception;GO:0009966 regulation of signal transduction;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VBV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C131-1", "uniprot_id": "HCAR1_MOUSE", "mass": 38927.0, "length": 343, "protein_name": "Hydroxycarboxylic acid receptor 1", "gene_name": "Hcar1", "organism": "Mouse", "refseq_name": "hydroxycarboxylic acid receptor 1", "refseq_ac": "NP_780729", "gene_names_uniprotkb": "Hcar1; Gpr81", "gene_names_refseq": "Gpr81; Hcar1", "protein_names_uniprotkb": "Hydroxycarboxylic acid receptor 1; G protein-coupled receptor 81", "protein_names_refseq": "G-protein coupled receptor 81; hydroxycarboxylic acid receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:243270); (R-MMU-3296197); (R-MMU-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "18174606;19047060;19633298;21750661;34428180", "class_list": "", "function": "Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway., [UniProtKB, PubMed, PubMed]; Data show that siRNA-mediated knockdown of PPARgamma in differentiated 3T3-L1 adipocytes showed a significant decrease in Gpr81 protein expression., [RefSeq, PubMed]; GPR81 couples to the Gi signaling pathway, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ36", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0050995 negative regulation of lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C131-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2N8-1", "uniprot_id": "GLT15_MOUSE", "mass": 72321.0, "length": 638, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 15", "gene_name": "Galnt15", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 15", "refseq_ac": "NP_084442", "gene_names_uniprotkb": "Galnt15; Galntl2", "gene_names_refseq": "4631401E18Rik; Galnt15; Galntl2; mpp-GalNAc-T15", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 15; 2.4.1.41; GalNAc-T-like protein 2; Polypeptide GalNAc transferase-like protein 2; Polypeptide N-acetylgalactosaminyltransferase-like protein 2; Protein-UDP acetylgalactosaminyltransferase-like protein 2; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2; pp-GaNTase-like protein 2", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2; galNAc-T-like protein 2; polypeptide GalNAc transferase-like protein 2; polypeptide N-acetylgalactosaminyltransferase 15; polypeptide N-acetylgalactosaminyltransferase-like 2; polypeptide N-acetylgalactosaminyltransferase-like protein 2; pp-GaNTase-like protein 2; protein-UDP acetylgalactosaminyltransferase-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:78754); (R-MMU-913709)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12651884;21750661;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 41, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KN88", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0030133 transport vesicle", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 7434, "hit_score": 0.4, "record_id": "Q9D2N8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZL4-1", "uniprot_id": "GPR22_MOUSE", "mass": 49019.0, "length": 432, "protein_name": "G protein-coupled receptor 22", "gene_name": "Gpr22", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 22", "refseq_ac": "NP_780400", "gene_names_uniprotkb": "Gpr22", "gene_names_refseq": "2900068K05Rik; Gpr22", "protein_names_uniprotkb": "G protein-coupled receptor 22", "protein_names_refseq": "G-protein coupled receptor 22; probable G-protein coupled receptor 22", "tax_id": 10090, "disease": "diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:73010)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12679517;18539757;21750661;35820727;38816768", "class_list": "", "function": "Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction. Publication Status: Online-Only, [RefSeq, PubMed]; Demonstrate GRR22 expression in mouse heart. Identified a protective role for GPR22 in response to hemodynamic stress resulting from increased afterload., [RefSeq, PubMed]; Orphan G protein-coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (By similarity). May be involved in ciliogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80UE1", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BZL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09131-1", "uniprot_id": "GSTO1_MOUSE", "mass": 27498.0, "length": 240, "protein_name": "Glutathione S-transferase omega-1", "gene_name": "Gsto1", "organism": "Mouse", "refseq_name": "glutathione S-transferase omega-1", "refseq_ac": "NP_034492", "gene_names_uniprotkb": "Gsto1; Gstx; Gtsttl", "gene_names_refseq": "Gsto-1; Gsto1; Gstx; Spg-r; p28", "protein_names_uniprotkb": "Glutathione S-transferase omega-1; 1.20.4.2; 1.8.5.1; 2.5.1.18; GSTO 1-1; GSTO-1; Glutathione S-transferase omega 1-1; Glutathione-dependent dehydroascorbate reductase; MMA(V) reductase; Monomethylarsonic acid reductase; S-(Phenacyl)glutathione reductase; SPG-R; p28", "protein_names_refseq": "Glutathione transferase omega 1 (GSTO 1-1) (p28); MMA(V) reductase; S-(Phenacyl)glutathione reductase; glutathione S-transferase omega 1-1; glutathione S-transferase omega-1; glutathione-S-transferase like; glutathione-dependent dehydroascorbate reductase; monomethylarsonic acid reductase", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 6 (Disease Ontology:DOID:0060198); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); colon adenocarcinoma (Disease Ontology:DOID:234)", "pathway": " (mmu:14873); (R-MMU-156581); (R-MMU-156590); (R-MMU-196836)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "21183079;21540332;21750661;22645316;24788674;33564842;33583732;34342641;34428180;36288343;37156632;37507081;9988762", "class_list": "", "function": "ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation., [RefSeq, PubMed]; Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis., [RefSeq, PubMed]; Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA)., [UniProtKB, UniProtKB]; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Also has glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid., [UniProtKB, UniProtKB]; Glutathione transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation., [RefSeq, PubMed]; Inhibition of glutathione S-transferase omega 1-catalyzed protein deglutathionylation suppresses adipocyte differentiation., [RefSeq, PubMed]; This gene encodes a member of the omega class of glutathione S-transferase (GST) proteins. GSTs are involved in the metabolism of xenobiotics and carcinogens. There is evidence that the encoded protein is involved in the biotransformation of arsenic. [provided by RefSeq, Dec 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TH87", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.2.1.2;1.8.-.-", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0016491 oxidoreductase activity;GO:0045174 glutathione dehydrogenase (ascorbate) activity;GO:0050610 methylarsonate reductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0031965 nuclear membrane;GO:0044297 cell body", "go_biological_process": "GO:0051280 negative regulation of release of sequestered calcium ion into cytosol;GO:0014810 positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion;GO:0051281 positive regulation of release of sequestered calcium ion into cytosol;GO:0042178 xenobiotic catabolic process;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O09131-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88416-1", "uniprot_id": "GPR33_MOUSE", "mass": 38446.0, "length": 339, "protein_name": "Probable G protein-coupled receptor 33", "gene_name": "Gpr33", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 33", "refseq_ac": "NP_032185", "gene_names_uniprotkb": "Gpr33", "gene_names_refseq": "Gpr33", "protein_names_uniprotkb": "Probable G protein-coupled receptor 33", "protein_names_refseq": "probable G-protein coupled receptor 33", "tax_id": 10090, "disease": "", "pathway": " (mmu:14762)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15987686;16595170;26740625;9653656", "class_list": "", "function": "Orphan receptor; could be a chemoattractant receptor., [UniProtKB]; Unexpectedly, the naturally occurring mutation of Arg(3.50) to His in GPR33 showed no difference from the wild-type receptor in several functional tests., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004875 complement receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88416-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88630-1", "uniprot_id": "GOSR1_MOUSE", "mass": 28489.0, "length": 250, "protein_name": "Golgi SNAP receptor complex member 1", "gene_name": "Gosr1", "organism": "Mouse", "refseq_name": "Golgi SNAP receptor complex member 1 isoform 1", "refseq_ac": "NP_058090", "gene_names_uniprotkb": "Gosr1; Gs28", "gene_names_refseq": "GOS-28; GOSRI; GS28; Gosr1", "protein_names_uniprotkb": "Golgi SNAP receptor complex member 1; 28 kDa Golgi SNARE protein; 28 kDa cis-Golgi SNARE p28; GOS-28", "protein_names_refseq": "28 kDa Golgi SNARE protein; 28 kDa cis-Golgi SNARE p28; Cis-Golgi SNARE; Golgi SNAP receptor complex member 1 isoform 1", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:53334); (R-MMU-6807878); (R-MMU-6811438)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;15250942", "class_list": "", "function": "Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91VU9", "ec_number_list": "", "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005797 Golgi medial cisterna;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0006906 vesicle fusion;GO:0048219 inter-Golgi cisterna vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01897-1", "uniprot_id": "HA1L_MOUSE", "mass": 40711.0, "length": 362, "protein_name": "H-2 class I histocompatibility antigen, L-D alpha chain", "gene_name": "H2-L", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H2-L", "gene_names_refseq": "", "protein_names_uniprotkb": "H-2 class I histocompatibility antigen, L-D alpha chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); colitis (Disease Ontology:DOID:0060180); Cytomegalovirus retinitis (Disease Ontology:DOID:0080160); COVID-19 (Disease Ontology:DOID:0080600); ankylosing spondylitis 1 (Disease Ontology:DOID:0080603); erythema nodosum (Disease Ontology:DOID:0080750); occupational asthma (Disease Ontology:DOID:0080820); birdshot chorioretinopathy (Disease Ontology:DOID:0111079); psoriasis 1 (Disease Ontology:DOID:0111286); sensorineural hearing loss (Disease Ontology:DOID:10003); pre-eclampsia (Disease Ontology:DOID:10591); spondyloarthropathy (Disease Ontology:DOID:1123); trachoma (Disease Ontology:DOID:11265); sarcoidosis (Disease Ontology:DOID:11335); retinal vasculitis (Disease Ontology:DOID:11563); otosclerosis (Disease Ontology:DOID:12185); Graves' disease (Disease Ontology:DOID:12361); vulva cancer (Disease Ontology:DOID:1245); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); thromboangiitis obliterans (Disease Ontology:DOID:12918); retinopathy of prematurity (Disease Ontology:DOID:13025); Moyamoya disease (Disease Ontology:DOID:13099); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); anterior uveitis (Disease Ontology:DOID:1407); cystic fibrosis (Disease Ontology:DOID:1485); Melkersson-Rosenthal syndrome (Disease Ontology:DOID:1761); hepatitis C (Disease Ontology:DOID:1883); Takayasu's arteritis (Disease Ontology:DOID:2508); synovitis (Disease Ontology:DOID:2703); dermatitis (Disease Ontology:DOID:2723); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); cerebral infarction (Disease Ontology:DOID:3526); acute retinal necrosis syndrome (Disease Ontology:DOID:3611); thrombophlebitis (Disease Ontology:DOID:3875); tuberculosis (Disease Ontology:DOID:399); scleroderma (Disease Ontology:DOID:419); cervical cancer (Disease Ontology:DOID:4362); allergic rhinitis (Disease Ontology:DOID:4481); central nervous system vasculitis (Disease Ontology:DOID:525); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); uveal melanoma (Disease Ontology:DOID:6039); reactive arthritis (Disease Ontology:DOID:6196); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); ankylosing spondylitis (Disease Ontology:DOID:7147); diabetic retinopathy (Disease Ontology:DOID:8947); allergic asthma (Disease Ontology:DOID:9415); Meniere's disease (Disease Ontology:DOID:9849); alopecia (Disease Ontology:DOID:987); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": "", "pathway_count": 0, "publication_count": 13, "publication_id_list": "1705528;22872234;28011936;31219806;34428180;35820727;36210013;37828378;6604582;6895103;6952248;7058332;9192660", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 51, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q31195;Q31196;Q31197", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0046978 TAP1 binding;GO:0046979 TAP2 binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0032398 MHC class Ib protein complex;GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006952 defense response;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P01897-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01898-1", "uniprot_id": "HA10_MOUSE", "mass": 37251.0, "length": 325, "protein_name": "H-2 class I histocompatibility antigen, Q10 alpha chain", "gene_name": "H2-Q10", "organism": "Mouse", "refseq_name": "H-2 class I histocompatibility antigen, Q10 alpha chain precursor", "refseq_ac": "NP_034521", "gene_names_uniprotkb": "H2-Q10", "gene_names_refseq": "H-2Q10; H2-K1; H2-Q10; Q10; Qa10", "protein_names_uniprotkb": "H-2 class I histocompatibility antigen, Q10 alpha chain", "protein_names_refseq": "H-2 class I histocompatibility antigen, Q10 alpha chain precursor; H-2 class I histocompatibility antigen, Q10 alpha chain; MHC class I transplantation antigen; MHC class II antigen K", "tax_id": 10090, "disease": "Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); colitis (Disease Ontology:DOID:0060180); Cytomegalovirus retinitis (Disease Ontology:DOID:0080160); COVID-19 (Disease Ontology:DOID:0080600); ankylosing spondylitis 1 (Disease Ontology:DOID:0080603); erythema nodosum (Disease Ontology:DOID:0080750); occupational asthma (Disease Ontology:DOID:0080820); graft-versus-host disease (Disease Ontology:DOID:0081267); birdshot chorioretinopathy (Disease Ontology:DOID:0111079); psoriasis 1 (Disease Ontology:DOID:0111286); sensorineural hearing loss (Disease Ontology:DOID:10003); pre-eclampsia (Disease Ontology:DOID:10591); spondyloarthropathy (Disease Ontology:DOID:1123); trachoma (Disease Ontology:DOID:11265); sarcoidosis (Disease Ontology:DOID:11335); retinal vasculitis (Disease Ontology:DOID:11563); otosclerosis (Disease Ontology:DOID:12185); Graves' disease (Disease Ontology:DOID:12361); vulva cancer (Disease Ontology:DOID:1245); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); thromboangiitis obliterans (Disease Ontology:DOID:12918); retinopathy of prematurity (Disease Ontology:DOID:13025); Moyamoya disease (Disease Ontology:DOID:13099); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); anterior uveitis (Disease Ontology:DOID:1407); cystic fibrosis (Disease Ontology:DOID:1485); Melkersson-Rosenthal syndrome (Disease Ontology:DOID:1761); hepatitis C (Disease Ontology:DOID:1883); Takayasu's arteritis (Disease Ontology:DOID:2508); synovitis (Disease Ontology:DOID:2703); dermatitis (Disease Ontology:DOID:2723); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); cerebral infarction (Disease Ontology:DOID:3526); acute retinal necrosis syndrome (Disease Ontology:DOID:3611); thrombophlebitis (Disease Ontology:DOID:3875); tuberculosis (Disease Ontology:DOID:399); scleroderma (Disease Ontology:DOID:419); cervical cancer (Disease Ontology:DOID:4362); allergic rhinitis (Disease Ontology:DOID:4481); central nervous system vasculitis (Disease Ontology:DOID:525); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); uveal melanoma (Disease Ontology:DOID:6039); reactive arthritis (Disease Ontology:DOID:6196); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); ankylosing spondylitis (Disease Ontology:DOID:7147); diabetic retinopathy (Disease Ontology:DOID:8947); allergic asthma (Disease Ontology:DOID:9415); Meniere's disease (Disease Ontology:DOID:9849); alopecia (Disease Ontology:DOID:987); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (mmu:15007); (R-MMU-1236974); (R-MMU-1236977); (R-MMU-198933); (R-MMU-6798695); (R-MMU-983170)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "17330941;24958902;25428506;2584927;27385590;2767053;30084848;30537346;30779550;31219806;31599954;34428180;34478713;3510743;36210013;6411351;6420070", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]; Ribosylation of the CD8alphabeta heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10., [RefSeq, PubMed]; These data demonstrate that H2-Q10 has multiple roles in the development of immune subsets and identify an overlap of recognition within the class Ib MHC that is likely to be relevant to the regulation of immunity., [RefSeq, PubMed]; This docking mode was conserved with that previously observed for Ly49C.H-2K(b) Indeed, structure-guided mutation of Ly49C indicated that Ly49C.H2-Q10 and Ly49C.H-2K(b) possess similar energetic footprints focused around residues located within the Ly49C beta4-stand and L5 loop, which contact the underside of the peptide-binding platform floor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 52, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O19475;Q31214;Q95HC3", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0046978 TAP1 binding;GO:0046979 TAP2 binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0032398 MHC class Ib protein complex;GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P01898-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01915-1", "uniprot_id": "HB22_MOUSE", "mass": 30049.0, "length": 264, "protein_name": "H-2 class II histocompatibility antigen, E-D beta chain", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "H-2 class II histocompatibility antigen, E-D beta chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "16393994;26495903;37828378;6087163;6310581", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0042613 MHC class II protein complex", "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002250 adaptive immune response;GO:0050870 positive regulation of T cell activation;GO:0050778 positive regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P01915-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02089-1", "uniprot_id": "HBB2_MOUSE", "mass": 15878.0, "length": 147, "protein_name": "Hemoglobin subunit beta-2", "gene_name": "Hbb-b2", "organism": "Mouse", "refseq_name": "hemoglobin subunit beta-2", "refseq_ac": "NP_058652", "gene_names_uniprotkb": "Hbb-b2", "gene_names_refseq": "AI036344; Hbb-b2; Hbb2; Hbbt2; beta2", "protein_names_uniprotkb": "Hemoglobin subunit beta-2; Beta-2-globin; Hemoglobin beta-2 chain; Hemoglobin beta-minor chain", "protein_names_refseq": "beta minor globin; beta min; hemoglobin subunit beta-2", "tax_id": 10090, "disease": "autosomal dominant beta thalassemia (Disease Ontology:DOID:0080770); delta beta-thalassemia (Disease Ontology:DOID:0080773); sickle cell disease (Disease Ontology:DOID:0081445); Heinz body anemia (Disease Ontology:DOID:0111363); familial erythrocytosis 6 (Disease Ontology:DOID:0111632); sickle cell anemia (Disease Ontology:DOID:10923); alpha thalassemia (Disease Ontology:DOID:1099); beta thalassemia (Disease Ontology:DOID:12241); malaria (Disease Ontology:DOID:12365); Parkinson's disease (Disease Ontology:DOID:14330); acute chest syndrome (Disease Ontology:DOID:1584); anemia (Disease Ontology:DOID:2355); hemoglobin C disease (Disease Ontology:DOID:2859); hemoglobinopathy (Disease Ontology:DOID:2860); congenital hemolytic anemia (Disease Ontology:DOID:589); polycythemia (Disease Ontology:DOID:8432)", "pathway": " (mmu:15130)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11207290;17322886;21183079;23806337;24129315;25428506;2926808;30084848;30779550;32152506;519759;8134391;999642", "class_list": "", "function": "Involved in oxygen transport from the lung to the various peripheral tissues., [UniProtKB]; This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues. This gene is one of a cluster of beta-hemoglobin genes that are distally regulated by a locus control region, and which are organized along the chromosome in the order of their developmental expression. In mouse, two major strain-specific haplotypes of the beta-globin gene cluster are found - a 'single' haplotype found in C57BL/-type strains, which includes two highly similar adult beta-globin genes, beta s and beta t, and a 'diffuse' haplotype found in strains such as BALB/c and 129Sv, which includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This gene represents the beta-minor adult gene found in the 'diffuse' haplotype. Primary chromosome 7 of the mouse reference genome assembly, which is derived from C57BL/6 strain mice, represents the 'single' haplotype, while the 'diffuse' haplotype is represented in the reference genome collection by the BALB/c strain alternate contig, NT_095534.1. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5D0E8", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0030492 hemoglobin binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0015670 carbon dioxide transport;GO:0048821 erythrocyte development;GO:0045646 regulation of erythrocyte differentiation;GO:0045639 positive regulation of myeloid cell differentiation;GO:0098869 cellular oxidant detoxification", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P02089-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02104-1", "uniprot_id": "HBE_MOUSE", "mass": 16137.0, "length": 147, "protein_name": "Hemoglobin subunit epsilon-Y2", "gene_name": "Hbb-y", "organism": "Mouse", "refseq_name": "hemoglobin subunit epsilon-Y2", "refseq_ac": "NP_032247", "gene_names_uniprotkb": "Hbb-y", "gene_names_refseq": "Ey; Hbb-y; Hby", "protein_names_uniprotkb": "Hemoglobin subunit epsilon-Y2; Epsilon-Y2-globin; Hemoglobin epsilon-Y2 chain", "protein_names_refseq": "epsilon Y globin; epsilon-Y2-globin; hemoglobin epsilon-Y2 chain; hemoglobin subunit epsilon-Y2", "tax_id": 10090, "disease": "sickle cell anemia (Disease Ontology:DOID:10923)", "pathway": " (mmu:15135)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "16393994;2444404;25428507;25605945;2926808;34428180;36583994;37507081;37828378;6177582;6250710;6274852;938477", "class_list": "", "function": "Hemoglobin epsilon chain is a beta-type chain found in early embryos., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62480;Q64358", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding;GO:0019825 oxygen binding", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0015670 carbon dioxide transport;GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P02104-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04187-1", "uniprot_id": "GRAB_MOUSE", "mass": 27470.0, "length": 247, "protein_name": "Granzyme B(G,H)", "gene_name": "Gzmb", "organism": "Mouse", "refseq_name": "granzyme B(G,H) preproprotein", "refseq_ac": "NP_038570", "gene_names_uniprotkb": "Gzmb; Ctla-1; Ctla1", "gene_names_refseq": "CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB; Gzmb", "protein_names_uniprotkb": "Granzyme B(G,H); 3.4.21.79; CCP1; CTLA-1; Cytotoxic cell protease 1; Fragmentin-2", "protein_names_refseq": "cytotoxic cell protease 1; fragmentin-2; granzyme B(G,H) preproprotein; granzyme B(G,H)", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); bronchiolitis obliterans (Disease Ontology:DOID:2799); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (mmu:14939); (R-MMU-5620971); (R-MMU-75108)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "3090449;3237717;3264185;3518058;3555842;35705808;8043949", "class_list": "", "function": "Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3555842, PubMed:35705808). It cleaves after Asp (PubMed:35705808). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (By similarity). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution (By similarity). Cleaves caspase-3 and -9 (CASP3 and CASP9, respectively) to give rise to active enzymes mediating apoptosis (PubMed:35705808). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (PubMed:35705808)., [UniProtKB, PubMed, PubMed, UniProtKB]; This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Mice lacking a functional copy of this gene exhibit impaired immune cell-mediated cytolysis. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48;2.3.1.-;3.4.21.79", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0046513 ceramide biosynthetic process;GO:0006915 apoptotic process;GO:0017148 negative regulation of translation;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04187-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04443-1", "uniprot_id": "HBB0_MOUSE", "mass": 16384.0, "length": 147, "protein_name": "Hemoglobin subunit beta-H0", "gene_name": "Hbb-bh0", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Hbb-bh0", "gene_names_refseq": "", "protein_names_uniprotkb": "Hemoglobin subunit beta-H0; Beta-H0-globin; Hemoglobin beta-H0 chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "delta beta-thalassemia (Disease Ontology:DOID:0080773); sickle cell anemia (Disease Ontology:DOID:10923)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2926808;6250710;6323438", "class_list": "", "function": "This is a minor early embryonic beta chain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61346", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P04443-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04444-1", "uniprot_id": "HBBZ_MOUSE", "mass": 16494.0, "length": 147, "protein_name": "Hemoglobin subunit beta-H1", "gene_name": "Hbb-bh1", "organism": "Mouse", "refseq_name": "hemoglobin subunit beta-H1", "refseq_ac": "NP_032245", "gene_names_uniprotkb": "Hbb-bh1", "gene_names_refseq": "Hbb-bh1; betaH1", "protein_names_uniprotkb": "Hemoglobin subunit beta-H1; Beta-H1-globin; Hemoglobin beta-H1 chain; Protein Z", "protein_names_refseq": "beta Hl globin; beta-H1-globin; hemoglobin beta-H1 chain; hemoglobin subunit beta-H1; minor beta-globin; protein Z", "tax_id": 10090, "disease": "delta beta-thalassemia (Disease Ontology:DOID:0080773); sickle cell anemia (Disease Ontology:DOID:10923)", "pathway": " (mmu:15132)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "2926808;34428180;6250710;6323438", "class_list": "", "function": "This is an embryonic beta-type chain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61347", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding;GO:0019825 oxygen binding", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0015670 carbon dioxide transport;GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P04444-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08884-1", "uniprot_id": "GRAE_MOUSE", "mass": 27494.0, "length": 248, "protein_name": "Granzyme E", "gene_name": "Gzme", "organism": "Mouse", "refseq_name": "granzyme E precursor", "refseq_ac": "NP_034503", "gene_names_uniprotkb": "Gzme; Ccp3; Ctla-6; Ctla6", "gene_names_refseq": "CCP3; Ctla-6; Ctla6; Gzme; MCSP-2", "protein_names_uniprotkb": "Granzyme E; 3.4.21.-; CCP3; CTL serine protease 2; Cytotoxic cell protease 3; Cytotoxic serine protease 2; D12; MCSP2", "protein_names_refseq": "CTL serine protease 2; D12; MCSP2; cytotoxic cell protease 3; cytotoxic serine protease 2; granzyme E precursor", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); bronchiolitis obliterans (Disease Ontology:DOID:2799); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:14942)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "25428506;3053963;3260382;3292281;3555842;8917549", "class_list": "", "function": "Serine protease probably necessary for target cell lysis in cell-mediated immune responses., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P97389", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0044194 cytolytic granule", "go_biological_process": "GO:0006508 proteolysis;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P08884-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C8B4-1", "uniprot_id": "GON7_MOUSE", "mass": 10346.0, "length": 98, "protein_name": "EKC/KEOPS complex subunit GON7", "gene_name": "Gon7", "organism": "Mouse", "refseq_name": "EKC/KEOPS complex subunit GON7", "refseq_ac": "NP_001136410", "gene_names_uniprotkb": "Gon7", "gene_names_refseq": "Gon7", "protein_names_uniprotkb": "EKC/KEOPS complex subunit GON7", "protein_names_refseq": "EKC/KEOPS complex subunit GON7; GON7, KEOPS complex subunit homolog; uncharacterized protein C14orf142 homolog", "tax_id": 10090, "disease": "Galloway-Mowat syndrome (Disease Ontology:DOID:0080694)", "pathway": " (mmu:100233175)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 plays a supporting role to the catalytic subunit OSGEP in the complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0002949 tRNA threonylcarbamoyladenosine modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C8B4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14431-1", "uniprot_id": "HA19_MOUSE", "mass": 23025.0, "length": 200, "protein_name": "H-2 class I histocompatibility antigen, Q9 alpha chain", "gene_name": "H2-Q9", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H2-Q9", "gene_names_refseq": "", "protein_names_uniprotkb": "H-2 class I histocompatibility antigen, Q9 alpha chain", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "3004940;34203471", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030881 beta-2-microglobulin binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0032398 MHC class Ib protein complex;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0051607 defense response to virus;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P14431-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31315-1", "uniprot_id": "GSX1_MOUSE", "mass": 27728.0, "length": 261, "protein_name": "GS homeobox 1", "gene_name": "Gsx1", "organism": "Mouse", "refseq_name": "GS homeobox 1", "refseq_ac": "NP_032204", "gene_names_uniprotkb": "Gsx1; Gsh-1; Gsh1", "gene_names_refseq": "Gsh-1; Gsh1; Gsx1", "protein_names_uniprotkb": "GS homeobox 1; Homeobox protein GSH-1", "protein_names_refseq": "GS homeobox 1; genomic screened homeo box 1; homeobox protein GSH-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14842)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1683707;8589431;8631293", "class_list": "", "function": "Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P31315-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33680-1", "uniprot_id": "GUC2A_MOUSE", "mass": 12467.0, "length": 116, "protein_name": "Guanylin", "gene_name": "Guca2a", "organism": "Mouse", "refseq_name": "guanylin precursor", "refseq_ac": "NP_032216", "gene_names_uniprotkb": "Guca2a; Guca2", "gene_names_refseq": "Guca2a; Guca2", "protein_names_uniprotkb": "Guanylin; Guanylate cyclase activator 2A", "protein_names_refseq": "guanylate cyclase activator 2 (guanylin 2, intestinal, heatstable); guanylin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14915); (R-MMU-8935690)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1409606;27246004;29289697;7713512", "class_list": "", "function": "Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins., [UniProtKB]; Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage, [RefSeq, PubMed]; Guanylin and uroguanylin, as well as their prohormones, do not seem to play a significant role in body weight regulation and glycemic control, suggesting that guanylin-family peptides do not show promise as targets for the treatment of obesity or diabetes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030250 guanylate cyclase activator activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P33680-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43081-1", "uniprot_id": "GUC1A_MOUSE", "mass": 22986.0, "length": 202, "protein_name": "Guanylyl cyclase-activating protein 1", "gene_name": "Guca1a", "organism": "Mouse", "refseq_name": "guanylyl cyclase-activating protein 1", "refseq_ac": "NP_032215", "gene_names_uniprotkb": "Guca1a; Gcap1; Gcap; Guca1", "gene_names_refseq": "GC-A; Gcap1; Guca1a; Guca1; mGCAP1", "protein_names_uniprotkb": "Guanylyl cyclase-activating protein 1; GCAP 1; Guanylate cyclase activator 1A", "protein_names_refseq": "GCAP 1; guanylyl cyclase-activating protein 1", "tax_id": 10090, "disease": "cone-rod dystrophy 14 (Disease Ontology:DOID:0080314)", "pathway": " (mmu:14913); (R-MMU-2514859)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15961391;21464903;25673692;29435986;7983048;9620085", "class_list": "", "function": "Mutant GCAP1, when under normal expression control, causes both rod and cone photoreceptors to lose function and degenerate, with cone cells being more severely affected, in keeping with the human disease phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor light response and recovery of response in bright light (PubMed:25673692)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a calcium-binding photoreceptor protein. The encoded protein may be involved in modulation of guanylyl cyclase activity, and in turn, the mammalian cone phototransduction cascade. Disruption of this gene results in the retinal degeneration associated with cone dystrophy. [provided by RefSeq, Dec 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0H3", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030249 guanylate cyclase regulator activity;GO:0008048 calcium sensitive guanylate cyclase activator activity", "go_cellular_component": "GO:0016020 membrane;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment;GO:0120199 cone photoreceptor outer segment", "go_biological_process": "GO:0031284 positive regulation of guanylate cyclase activity;GO:0071277 cellular response to calcium ion;GO:0007601 visual perception;GO:0009966 regulation of signal transduction;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P43081-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46425-1", "uniprot_id": "GSTP2_MOUSE", "mass": 23537.0, "length": 210, "protein_name": "Glutathione S-transferase P 2", "gene_name": "Gstp2", "organism": "Mouse", "refseq_name": "glutathione S-transferase P 2", "refseq_ac": "NP_861461", "gene_names_uniprotkb": "Gstp2; Gstpia", "gene_names_refseq": "GSTpiA; Gst-3; Gst3; Gstp2", "protein_names_uniprotkb": "Glutathione S-transferase P 2; 2.5.1.18; GST YF-YF; GST class-pi; GST-piA; Gst P2", "protein_names_refseq": "GST YF-YF; GST class-pi; GST-piA; Gst p-2; glutathione S-transferase P 2; gst P2", "tax_id": 10090, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenoma (Disease Ontology:DOID:0050860); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); drug allergy (Disease Ontology:DOID:0060500); late onset Parkinson's disease (Disease Ontology:DOID:0060892); prostate cancer (Disease Ontology:DOID:10283); lymphoid leukemia (Disease Ontology:DOID:1037); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); osteoporosis (Disease Ontology:DOID:11476); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); allergic disease (Disease Ontology:DOID:1205); Graves' disease (Disease Ontology:DOID:12361); cholestasis (Disease Ontology:DOID:13580); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); respiratory system disease (Disease Ontology:DOID:1579); breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); colon adenocarcinoma (Disease Ontology:DOID:234); multiple sclerosis (Disease Ontology:DOID:2377); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); testicular cancer (Disease Ontology:DOID:2998); acute kidney failure (Disease Ontology:DOID:3021); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); carotid artery disease (Disease Ontology:DOID:3407); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); toxic encephalopathy (Disease Ontology:DOID:3602); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pulmonary fibrosis (Disease Ontology:DOID:3770); bronchus carcinoma (Disease Ontology:DOID:3904); lung non-small cell carcinoma (Disease Ontology:DOID:3908); liver disease (Disease Ontology:DOID:409); conjunctivochalasis (Disease Ontology:DOID:4250); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); movement disease (Disease Ontology:DOID:480); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); cholangiocarcinoma (Disease Ontology:DOID:4947); bone marrow disease (Disease Ontology:DOID:4961); peripheral nervous system disease (Disease Ontology:DOID:574); hepatocellular carcinoma (Disease Ontology:DOID:684); hematopoietic system disease (Disease Ontology:DOID:74); peritonitis (Disease Ontology:DOID:8283); lung disease (Disease Ontology:DOID:850); prostate carcinoma in situ (Disease Ontology:DOID:8634); myeloid leukemia (Disease Ontology:DOID:8692); psoriasis (Disease Ontology:DOID:8893); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); meningitis (Disease Ontology:DOID:9471); multiple myeloma (Disease Ontology:DOID:9538); senile cataract (Disease Ontology:DOID:9669); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:14869)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;26740625;33437989;7982937;8135745", "class_list": "", "function": "Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration., [UniProtKB, UniProtKB]; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cannot metabolize 1-chloro-2,4-dinitrobenzene., [UniProtKB]; Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 70, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q505C3", "ec_number_list": "1.11.1.-;4.4.1.20;2.5.1.18;1.20.4.2;1.8.5.1;5.3.3.-;5.3.99.2;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0005504 fatty acid binding;GO:0015643 toxic substance binding;GO:0019901 protein kinase binding;GO:0035730 S-nitrosoglutathione binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0097057 TRAF2-GSTP1 complex", "go_biological_process": "GO:0006469 negative regulation of protein kinase activity;GO:0032691 negative regulation of interleukin-1 beta production;GO:0032720 negative regulation of tumor necrosis factor production;GO:0043651 linoleic acid metabolic process;GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P46425-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51655-1", "uniprot_id": "GPC4_MOUSE", "mass": 62586.0, "length": 557, "protein_name": "Glypican-4", "gene_name": "Gpc4", "organism": "Mouse", "refseq_name": "glypican-4 precursor", "refseq_ac": "NP_032176", "gene_names_uniprotkb": "Gpc4", "gene_names_refseq": "9530073D23Rik; Gpc4; K-glypican", "protein_names_uniprotkb": "Glypican-4; K-glypican", "protein_names_refseq": "glypican-4 precursor", "tax_id": 10090, "disease": "Keipert syndrome (Disease Ontology:DOID:0111842)", "pathway": " (mmu:14735); (R-MMU-1971475); (R-MMU-2022928); (R-MMU-2024096); (R-MMU-975634); (R-MMU-9769735); (R-MMU-9769739)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "15240697;25428506;30084848;30982611;34428180;36057966;37321444;37828378;7657705", "class_list": "glycogene", "function": "Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system., [UniProtKB]; Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling., [RefSeq, PubMed]; Intracellular accumulation of tau oligomers in astrocytes and their synaptotoxic action rely on Amyloid Precursor Protein Intracellular Domain-dependent expression of Glypican-4., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 39, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q923C8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0016477 cell migration;GO:0016055 Wnt signaling pathway;GO:0009966 regulation of signal transduction;GO:0099560 synaptic membrane adhesion;GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P51655-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83854-1", "uniprot_id": "GPCR_MOUSE", "mass": 1192.0, "length": 10, "protein_name": "Putative G protein-coupled receptor", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative G protein-coupled receptor", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P83854-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UWA6-1", "uniprot_id": "GUC2C_MOUSE", "mass": 123232.0, "length": 1072, "protein_name": "Guanylyl cyclase C", "gene_name": "Gucy2c", "organism": "Mouse", "refseq_name": "guanylyl cyclase C isoform 1 precursor", "refseq_ac": "NP_001120790", "gene_names_uniprotkb": "Gucy2c; Guc2c", "gene_names_refseq": "GC-C; Gcc; Gucy2c", "protein_names_uniprotkb": "Guanylyl cyclase C; 4.6.1.2; GC-C; Heat-stable enterotoxin receptor; Intestinal guanylate cyclase; STA receptor", "protein_names_refseq": "STA receptor; guanylyl cyclase C isoform 1 precursor; guanylyl cyclase C; heat-stable enterotoxin receptor; intestinal guanylate cyclase", "tax_id": 10090, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); congenital diarrhea 6 (Disease Ontology:DOID:0060780); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14917); (R-MMU-8935690)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "25428506;30642983;34428180;35355987;35820727;36548082", "class_list": "", "function": "Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP., [UniProtKB, UniProtKB]; Intestinal neuropod cell GUCY2C regulates visceral pain. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q499D2;Q8JZQ6", "ec_number_list": "4.6.1.2", "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0015643 toxic substance binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0042127 regulation of cell population proliferation;GO:0009636 response to toxic substance;GO:0007168 receptor guanylyl cyclase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UWA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V3G7-1", "uniprot_id": "GRM2A_MOUSE", "mass": 36441.0, "length": 320, "protein_name": "GRAM domain-containing protein 2A", "gene_name": "Gramd2a", "organism": "Mouse", "refseq_name": "GRAM domain-containing protein 2A isoform 2", "refseq_ac": "NP_001028670", "gene_names_uniprotkb": "Gramd2a; Gramd2", "gene_names_refseq": "Gramd2a; Gramd2", "protein_names_uniprotkb": "GRAM domain-containing protein 2A; GRAM domain-containing protein 2", "protein_names_refseq": "GRAM domain containing 2; GRAM domain-containing protein 2A isoform 2; GRAM domain-containing protein 2A; GRAM domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:546134)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Participates in the organization ofendoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSP5;Q3V3E4", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:2001256 regulation of store-operated calcium entry;GO:0061817 endoplasmic reticulum-plasma membrane tethering", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3V3G7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QNV8-1", "uniprot_id": "HEAT9_MOUSE", "mass": 65861.0, "length": 569, "protein_name": "Protein HEATR9", "gene_name": "Heatr9", "organism": "Mouse", "refseq_name": "protein HEATR9", "refseq_ac": "NP_001039008", "gene_names_uniprotkb": "Heatr9; Gm11435", "gene_names_refseq": "Gm11435; Heatr9", "protein_names_uniprotkb": "Protein HEATR9; HEAT repeat-containing protein 9", "protein_names_refseq": "HEAT repeat-containing protein 9; protein HEATR9", "tax_id": 10090, "disease": "", "pathway": " (mmu:629303)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32678841", "class_list": "", "function": "Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0009615 response to virus;GO:0034097 response to cytokine;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5QNV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RL51-1", "uniprot_id": "GSTCD_MOUSE", "mass": 70618.0, "length": 634, "protein_name": "Glutathione S-transferase C-terminal domain-containing protein", "gene_name": "Gstcd", "organism": "Mouse", "refseq_name": "glutathione S-transferase C-terminal domain-containing protein", "refseq_ac": "NP_080507", "gene_names_uniprotkb": "Gstcd", "gene_names_refseq": "4933434L15Rik; Gstcd", "protein_names_uniprotkb": "Glutathione S-transferase C-terminal domain-containing protein", "protein_names_refseq": "glutathione S-transferase C-terminal domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67553)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31513609;34418053", "class_list": "", "function": "Data potentially highlight an unrecognised function of GSTCD in mediating inflammatory signals that affect airway caliber, and may in part underlie the genetic associations seen at the GSTCD locus with lung function and COPD phenotypes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8I1;Q8BXR2;Q8BYY6;Q9CTV2;Q9CUA9;Q9CXU7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0060541 respiratory system development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5RL51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61039-1", "uniprot_id": "HAND2_MOUSE", "mass": 23666.0, "length": 217, "protein_name": "Heart- and neural crest derivatives-expressed protein 2", "gene_name": "Hand2", "organism": "Mouse", "refseq_name": "heart- and neural crest derivatives-expressed protein 2", "refseq_ac": "NP_034532", "gene_names_uniprotkb": "Hand2; Dhand; Hed; Thing2", "gene_names_refseq": "Ehand2; Hand2; Hed; Th2; Thing2; bHLHa26; dHAND", "protein_names_uniprotkb": "Heart- and neural crest derivatives-expressed protein 2; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; Helix-loop-helix transcription factor expressed in embryo and deciduum; Thing-2; dHAND", "protein_names_refseq": "deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; heart and neural crest derivatives expressed transcript 2; heart- and neural crest derivatives-expressed protein 2; helix-loop-helix transcription factor expressed in embryo and deciduum; thing-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:15111)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10769237;10804186;10924525;7671815;8533092;9171826;9671575", "class_list": "", "function": "Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61100", "ec_number_list": "", "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0001967 suckling behavior;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61039-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64523-1", "uniprot_id": "H2A2C_MOUSE", "mass": 13988.0, "length": 129, "protein_name": "Histone H2A type 2-C", "gene_name": "H2ac20", "organism": "Mouse", "refseq_name": "histone H2A type 2-C", "refseq_ac": "NP_783593", "gene_names_uniprotkb": "H2ac20; Hist2h2ab; Hist2h2ac", "gene_names_refseq": "H2a-613b; H2ac20; Hist2h2ac", "protein_names_uniprotkb": "Histone H2A type 2-C; H2A-clustered histone 20; H2a-613B", "protein_names_refseq": "histone 2, H2ac; histone H2A type 2-C; histone cluster 2, H2ac", "tax_id": 10090, "disease": "", "pathway": " (mmu:319176); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 18, "publication_count": 21, "publication_id_list": "12408966;15509584;15525528;16699504;21925322;24352239;24681537;25428506;27105115;30084848;30154464;30779550;32152506;33300544;33725478;34428180;35984892;36288343;37507081;39627609;8858345", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CGP3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q64523-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQN9-1", "uniprot_id": "GP142_MOUSE", "mass": 40758.0, "length": 365, "protein_name": "G protein-coupled receptor 142", "gene_name": "Gpr142", "organism": "Mouse", "refseq_name": "G protein-coupled receptor 142 isoform 1", "refseq_ac": "NP_861414", "gene_names_uniprotkb": "Gpr142", "gene_names_refseq": "Gpr142; PGR2", "protein_names_uniprotkb": "G protein-coupled receptor 142", "protein_names_refseq": "G protein-coupled receptor 142 isoform 1; G protein-coupled receptor PGR2; probable G-protein coupled receptor 142", "tax_id": 10090, "disease": "", "pathway": " (mmu:217302)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14623098;16378626;27104960;27322810;27807998;30472415;30767071", "class_list": "", "function": "GPR142 functions as a sensor of aromatic amino acids, controlling GIP but also CCK and GLP-1 as well as insulin and glucagon in the pancreas., [RefSeq, PubMed]; GPR142 mRNA showed a ubiquitous expression both in the brain and in various peripheral glands and organs in pre- and postnatal development., [RefSeq, PubMed]; Highly selective G protein-coupled receptor for aromatic amino acids specifically L-Tryptophan (L-Trp) and L-Phenylalanine (L-Phe), with L-Trp being the most potent and efficacious agonist (PubMed:27104960, PubMed:27322810, PubMed:30472415). GPR142 agonists triggers the activation of both GNAQ/G(q) and GNAI1/G(i)signaling pathways (PubMed:27104960). L-Trp stimulates glucose-induced insulin secretion and triggers G(q)-mediated signaling (PubMed:27104960). GPR142 appears to have a role as a sensor of aromatic essential amino acids controlling the secretion of both insulin in the pancreas and other gastrointestinal hormones including glucagon but also CCK and incretin in the gastrointestinal-tract, contributing to the control of glucose homeostasis by coordinating pancreatic and gut hormone secretion (PubMed:27104960, PubMed:27322810, PubMed:30472415)., [UniProtKB, PubMed, PubMed, PubMed]; The importance of Gpr142 in the maintenance of pancreatic beta-cell function., [RefSeq, PubMed]; These findings demonstrate GPR142 is a Tryptophan receptor critically required for insulin and incretin hormone regulation and suggest GPR142 agonists may be effective therapies that leverage amino acid sensing pathways for the treatment of type 2 diabetes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030054 cell junction", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0042593 glucose homeostasis;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7TQN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UC6-1", "uniprot_id": "GPR62_MOUSE", "mass": 37148.0, "length": 358, "protein_name": "G protein-coupled receptor 62", "gene_name": "Gpr62", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 62", "refseq_ac": "NP_001153124", "gene_names_uniprotkb": "Gpr62", "gene_names_refseq": "4933402E03Rik; Gpr62", "protein_names_uniprotkb": "G protein-coupled receptor 62", "protein_names_refseq": "G protein-coupled receptor 61 pseudogene; G protein-coupled receptor GPR62; G-protein coupled receptor 62; probable G-protein coupled receptor 62", "tax_id": 10090, "disease": "", "pathway": " (mmu:436090)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12679517;28912303;34428180", "class_list": "", "function": "Orphan G protein-coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28912303). Has spontaneous activity for beta-arrestin recruitment (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEQ6", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding;GO:1990763 arrestin family protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0010008 endosome membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0050850 positive regulation of calcium-mediated signaling;GO:0038035 ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80UC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UC8-1", "uniprot_id": "GP139_MOUSE", "mass": 39758.0, "length": 345, "protein_name": "Probable G protein-coupled receptor 139", "gene_name": "Gpr139", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 139", "refseq_ac": "NP_001019309", "gene_names_uniprotkb": "Gpr139; Gm495; Gprg1; Pgr3", "gene_names_refseq": "GPRg1; Gm495; Gpr139; PGR3", "protein_names_uniprotkb": "Probable G protein-coupled receptor 139; G protein-coupled receptor PGR3; G(q)-coupled orphan receptor GPRg1", "protein_names_refseq": "G protein-coupled receptor PGR3; g(q)-coupled orphan receptor GPRg1; orphan G protein-coupled receptor TRHRL2; probable G-protein coupled receptor 139", "tax_id": 10090, "disease": "", "pathway": " (mmu:209776)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12679517;15845401;16378626;36347339", "class_list": "", "function": "GPR139 mRNA was predominantly expressed in specific areas of mouse brain during pre- and postnatal development., [RefSeq, PubMed]; Orphan receptor. Seems to act through a G(q/11)-mediated pathway., [UniProtKB]; The orphan G protein-coupled receptor, GPR139, is expressed in the hypothalamus and is involved in the regulation of body mass, blood glucose, and insulin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q059X1", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding;GO:0008188 neuropeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80UC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFU2-1", "uniprot_id": "H2A3_MOUSE", "mass": 14121.0, "length": 130, "protein_name": "Histone H2A type 3", "gene_name": "H2ac25", "organism": "Mouse", "refseq_name": "histone H2A type 3", "refseq_ac": "NP_835736", "gene_names_uniprotkb": "H2ac25; H2aw; Hist3h2a", "gene_names_refseq": "H2ac25; H2aw; Hist3h2a", "protein_names_uniprotkb": "Histone H2A type 3; H2A-clustered histone 25", "protein_names_refseq": "H2A.W histone; histone 3, H2a; histone H2A type 3; histone cluster 3, H2a", "tax_id": 10090, "disease": "", "pathway": " (mmu:319162); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "12408966;15509584;15525528;16699504;21925322;22872234;24352239;24681537;27105115;27615797;29084613;30154464;36288343;39927985", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0006337 nucleosome disassembly;GO:0070914 UV-damage excision repair;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BFU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFW9-1", "uniprot_id": "GTR12_MOUSE", "mass": 67336.0, "length": 622, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 12", "gene_name": "Slc2a12", "organism": "Mouse", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 12", "refseq_ac": "NP_849265", "gene_names_uniprotkb": "Slc2a12; Glut12", "gene_names_refseq": "GLUT-12; Glut12; Slc2a12", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 12; GLUT-12; Glucose transporter type 12", "protein_names_refseq": "facilitated glucose transporter; glucose transporter type 12; solute carrier family 2, facilitated glucose transporter member 12; solute carrier family 2, member 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:353169); (R-MMU-189200)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12890477;15465484;19076329;21067453;23041416;30084848;32176854;32690690;34428180", "class_list": "glycogene", "function": "Analysis of Glut12 expression in mouse preimplantation embryos, [RefSeq, PubMed]; Effect of aging and obesity on GLUT12 expression in small intestine, adipose tissue, muscle, and kidney and its regulation by docosahexaenoic acid and exercise in mice. Erratum:[Appl Physiol Nutr Metab. 2021 Jul;46(7):846-847. doi: 10.1139/apnm-2021-0402. PMID: 34185593], [RefSeq, PubMed]; Expression in adipose tissue, [RefSeq, PubMed]; GLUT8 and GLUT12 exhibit dramatic differences in trafficking from the plasma membrane, [RefSeq, PubMed]; Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice., [RefSeq, PubMed]; Insulin-independent facilitative glucose transporter., [UniProtKB, PubMed]; XXX amino acids, specifically the position of a proline -2 from the dileucine residues, influence the affinity of APs for GLUT8 and GLUT12, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q14B60;Q3UPR6;Q8BZB7", "ec_number_list": "", "go_molecular_function": "GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030054 cell junction;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0072359 circulatory system development;GO:1904659 D-glucose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BFW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHX1-1", "uniprot_id": "HAUS1_MOUSE", "mass": 31379.0, "length": 278, "protein_name": "HAUS augmin-like complex subunit 1", "gene_name": "Haus1", "organism": "Mouse", "refseq_name": "HAUS augmin-like complex subunit 1 isoform 1", "refseq_ac": "NP_666201", "gene_names_uniprotkb": "Haus1; Ccdc5", "gene_names_refseq": "Ccdc5; HEI-C; Haus1", "protein_names_uniprotkb": "HAUS augmin-like complex subunit 1; Coiled-coil domain-containing protein 5", "protein_names_refseq": "HAUS augmin-like complex subunit 1 isoform 1; coiled-coil domain-containing protein 5; spindle associated", "tax_id": 10090, "disease": "", "pathway": " (mmu:225745); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "21750661;25428506;25605945;30084848;30779550;31219806;34203471;34428180", "class_list": "", "function": "Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIH2;Q8R1M1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005829 cytosol;GO:0070652 HAUS complex;GO:1990498 mitotic spindle microtubule", "go_biological_process": "GO:0051301 cell division;GO:0007098 centrosome cycle;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BHX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BL07-1", "uniprot_id": "GP150_MOUSE", "mass": 46519.0, "length": 427, "protein_name": "Probable G protein-coupled receptor 150", "gene_name": "Gpr150", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 150", "refseq_ac": "NP_780704", "gene_names_uniprotkb": "Gpr150; Pgr11", "gene_names_refseq": "C030001A19Rik; Gpr150; PGR11", "protein_names_uniprotkb": "Probable G protein-coupled receptor 150; G protein-coupled receptor PGR11", "protein_names_refseq": "G-protein coupled receptor PGR11; probable G-protein coupled receptor 150", "tax_id": 10090, "disease": "", "pathway": " (mmu:238725); (R-MMU-418555)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12679517", "class_list": "", "function": "Orphan receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q147V7;Q80UD4", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BL07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BX79-1", "uniprot_id": "GPR21_MOUSE", "mass": 39509.0, "length": 349, "protein_name": "Probable G protein-coupled receptor 21", "gene_name": "Gpr21", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 21", "refseq_ac": "NP_796357", "gene_names_uniprotkb": "Gpr21", "gene_names_refseq": "C230004C13Rik; Gpr21", "protein_names_uniprotkb": "Probable G protein-coupled receptor 21", "protein_names_refseq": "G protein-coupled receptor GPR21; probable G-protein coupled receptor 21", "tax_id": 10090, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:338346)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12679517;22155242;22653059;25428506;27243589;34782333", "class_list": "", "function": "Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms., [RefSeq, PubMed]; GPR21 has a critical function in coordinating macrophage proinflammatory activity in the context of obesity-induced insulin resistance, [RefSeq, PubMed]; GPR21 is up-regulated in type 2 diabetes model. Publication Status: Online-Only, [RefSeq, PubMed]; Orphan receptor., [UniProtKB]; These findings suggest that GPR21 may play an important role in regulating body weight and glucose metabolism., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80T46", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042593 glucose homeostasis;GO:0040018 positive regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BX79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZA7-1", "uniprot_id": "GPR26_MOUSE", "mass": 37747.0, "length": 337, "protein_name": "G protein-coupled receptor 26", "gene_name": "Gpr26", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 26", "refseq_ac": "NP_775586", "gene_names_uniprotkb": "Gpr26", "gene_names_refseq": "9630036A11Rik; A730021D22; Gpr26", "protein_names_uniprotkb": "G protein-coupled receptor 26", "protein_names_refseq": "G-protein coupled receptor 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:233919)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12679517;17363172;21924326;22815809;33577134", "class_list": "", "function": "Constitutive activity of GPR26 regulated by ubiquitin-dependent degradation and its antitumor role., [RefSeq, PubMed]; Data indicate that Gpr26 is important for emotion regulation in mice, a function probably mediated by the phosphorylation of CREB in the central amygdala., [RefSeq, PubMed]; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP (By similarity)., [UniProtKB]; These findings identified a key role of GPR26 as a central regulator of energy homeostasis though modulation of hypothalamic AMPK activation. Erratum:[PLoS One. 2012;7(8): doi/10.1371/annotation/3629b4c2-4810-4bbd-ae13-53d3d01bce60], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80T55;Q8BXZ5", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BZA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGP0-1", "uniprot_id": "H2B3B_MOUSE", "mass": 13908.0, "length": 126, "protein_name": "Histone H2B type 3-B", "gene_name": "H2bc26", "organism": "Mouse", "refseq_name": "histone H2B type 3-B", "refseq_ac": "NP_001380452", "gene_names_uniprotkb": "H2bc26; H2bc26-ps; H2bu1-ps; H2bu1; Hist3h2bb-ps; Hist3h2bb", "gene_names_refseq": "4930534G10Rik; 4933432H21; B2Hist3h2bb; H2bc26-ps; H2bc26; H2bu1-ps; H2bu1; Hist3h2bb-ps; Hist3h2bb", "protein_names_uniprotkb": "Histone H2B type 3-B; H2B-clustered histone 26; H2B.U histone 1", "protein_names_refseq": "H2B.U histone 1, pseudogene; histone 3, H2bb; histone H2B type 3-B; histone cluster 3, H2bb, pseudogene", "tax_id": 10090, "disease": "", "pathway": " (mmu:382522); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214847); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-606279); (R-MMU-69473); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 20, "publication_count": 15, "publication_id_list": "12408966;15197225;16039583;20647423;21925322;22389435;24681537;26495903;26740625;27105115;30084848;30154464;31645732;32822587;33822842", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2b family. [provided by RefSeq, Feb 2021]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3B7Z7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8CGP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGP7-1", "uniprot_id": "H2A1K_MOUSE", "mass": 14150.0, "length": 130, "protein_name": "Histone H2A type 1-K", "gene_name": "H2ac15", "organism": "Mouse", "refseq_name": "histone H2A type 1-K", "refseq_ac": "NP_835490", "gene_names_uniprotkb": "H2ac15; Hist1h2ak", "gene_names_refseq": "H2ac15; Hist1h2ak", "protein_names_uniprotkb": "Histone H2A type 1-K", "protein_names_refseq": "histone 1, H2ak; histone H2A type 1-K; histone cluster 1, H2ak", "tax_id": 10090, "disease": "", "pathway": " (mmu:319169); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 18, "publication_count": 16, "publication_id_list": "10967031;12408966;15509584;15525528;16699504;18250455;21925322;24352239;24681537;25605945;27105115;30154464;33300544;33725478;35984892;36288343", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VE75", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8CGP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K087-1", "uniprot_id": "CML2_MOUSE", "mass": 40951.0, "length": 353, "protein_name": "Chemerin-like receptor 2", "gene_name": "Cmklr2", "organism": "Mouse", "refseq_name": "chemerin-like receptor 2", "refseq_ac": "NP_666362", "gene_names_uniprotkb": "Cmklr2; Gpr1", "gene_names_refseq": "Cmklr2; Gpr1", "protein_names_uniprotkb": "Chemerin-like receptor 2; Chemerin chemokine-like receptor 2; Chemokine-like receptor 2; G protein-coupled receptor 1", "protein_names_refseq": "G protein-coupled receptor 1; chemerin-like receptor 2; chemokine-like receptor 2; probable G-protein coupled receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:241070)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20385583;22449967;24589776;24895415;29799787;34207497;35326488", "class_list": "", "function": "A maternal germline differentially methylated region (DMR) at the mouse Gpr1/Zdbf2 (DBF-type zinc finger-containing protein 2) locus, which controls the paternal-specific expression of long isoforms of Zdbf2 (Liz) in the early embryo, [RefSeq, PubMed]; An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of differentially methylated regions within the Gpr1-Zdbf2 imprinted domain., [RefSeq, PubMed]; Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:24895415). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (PubMed:29799787)., [UniProtKB, PubMed, PubMed]; Results identified a novel, paternally expressed, long intergenic non-coding Zdbf2 variant (Zdbf2linc) transcribed from maternally methylated Gpr1 during early embryogenesis in the mouse., [RefSeq, PubMed]; The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with beta-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042923 neuropeptide binding;GO:0097003 adipokinetic hormone receptor activity;GO:0097004 adipokinetic hormone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0097648 G protein-coupled receptor complex", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K087-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1B9-1", "uniprot_id": "GLT18_MOUSE", "mass": 71096.0, "length": 622, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 18", "gene_name": "Galnt18", "organism": "Mouse", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 18 isoform 1", "refseq_ac": "NP_776100", "gene_names_uniprotkb": "Galnt18; Galntl4", "gene_names_refseq": "2900011G21Rik; Galnt18; Galntl4; galNAc-T18; mpp-GalNAc-T18(O18)", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 18; 2.4.1.41; GalNAc-T-like protein 4; GalNAc-T18; Polypeptide GalNAc transferase 18; Polypeptide GalNAc transferase-like protein 4; Polypeptide N-acetylgalactosaminyltransferase-like protein 4; Protein-UDP acetylgalactosaminyltransferase-like protein 4; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4; pp-GaNTase-like protein 4", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4; galNAc-T-like protein 4; polypeptide GalNAc transferase 18; polypeptide GalNAc transferase-like protein 4; polypeptide N-acetylgalactosaminyltransferase 18 isoform 1; pp-GaNTase-like protein 4; protein-UDP acetylgalactosaminyltransferase-like protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:233733); (R-MMU-913709)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;27802388;34678516", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine (GalNAc) residue from UDP-GalNAc to a serine or threonine residue on the protein receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 42, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 1.1, "record_id": "Q8K1B9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2X8-1", "uniprot_id": "GO45_MOUSE", "mass": 45541.0, "length": 403, "protein_name": "Golgin-45", "gene_name": "Blzf1", "organism": "Mouse", "refseq_name": "golgin-45 isoform b", "refseq_ac": "NP_001153680", "gene_names_uniprotkb": "Blzf1", "gene_names_refseq": "1700030G05Rik; Blzf1l; Blzf1; Golgin-45; Jem-1", "protein_names_uniprotkb": "Golgin-45; Basic leucine zipper nuclear factor 1", "protein_names_refseq": "golgin-45 isoform b", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:66352); (R-MMU-162658)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11739401;25428506;28049725;30084848;30779550;34428180;35820727", "class_list": "", "function": "Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJC4;Q8C0U6;Q9DAV7", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0043001 Golgi to plasma membrane protein transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R2X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VH37-1", "uniprot_id": "HDAC8_MOUSE", "mass": 41772.0, "length": 377, "protein_name": "Histone deacetylase 8", "gene_name": "Hdac8", "organism": "Mouse", "refseq_name": "histone deacetylase 8 isoform 2", "refseq_ac": "NP_001300671", "gene_names_uniprotkb": "Hdac8", "gene_names_refseq": "2610007D20Rik; Hdac8", "protein_names_uniprotkb": "Histone deacetylase 8; 3.5.1.-; 3.5.1.98; HD8; Protein deacetylase HDAC8; Protein decrotonylase HDAC8", "protein_names_refseq": "HD8; histone deacetylase 8 isoform 2; protein deacetylase HDAC8; protein decrotonylase HDAC8", "tax_id": 10090, "disease": "Wilson-Turner syndrome (Disease Ontology:DOID:0060814); Cornelia de Lange syndrome 5 (Disease Ontology:DOID:0080509); Hirschsprung's disease (Disease Ontology:DOID:10487); hypertension (Disease Ontology:DOID:10763); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); renovascular hypertension (Disease Ontology:DOID:1591); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (mmu:70315); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-350054)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11533236;21750661;38473789", "class_list": "", "function": "Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones., [UniProtKB, UniProtKB]; Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9474, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V270;Q9D0K6", "ec_number_list": "3.5.1.-;3.5.1.98;3.5.1.48;3.5.1.62", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0019213 deacetylase activity;GO:0051879 Hsp90 protein binding;GO:0004407 histone deacetylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:1904322 cellular response to forskolin;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VH37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91W53-1", "uniprot_id": "GOGA7_MOUSE", "mass": 15792.0, "length": 137, "protein_name": "Golgin subfamily A member 7", "gene_name": "Golga7", "organism": "Mouse", "refseq_name": "golgin subfamily A member 7", "refseq_ac": "NP_001035949", "gene_names_uniprotkb": "Golga7; MNCb-1213", "gene_names_refseq": "C130038N16Rik; GCP16; GOLGA3AP1; Golga7; HSPC041", "protein_names_uniprotkb": "Golgin subfamily A member 7", "protein_names_refseq": "golgi autoantigen, golgin subfamily a, 7; golgin subfamily A member 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:57437); (R-MMU-6798695); (R-MMU-9648002)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "26495903;26740625;32152506;34428180", "class_list": "", "function": "May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BN18;Q9JJE0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005795 Golgi stack;GO:0002178 palmitoyltransferase complex", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0006612 protein targeting to membrane;GO:0050821 protein stabilization;GO:0043001 Golgi to plasma membrane protein transport;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91W53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WD0-1", "uniprot_id": "GP108_MOUSE", "mass": 63981.0, "length": 569, "protein_name": "Protein GPR108", "gene_name": "Gpr108", "organism": "Mouse", "refseq_name": "protein GPR108 isoform 2 precursor", "refseq_ac": "NP_001295001", "gene_names_uniprotkb": "Gpr108; Lustr2", "gene_names_refseq": "1810015L19Rik; Gpr108; Lustr2", "protein_names_uniprotkb": "Protein GPR108; Lung seven transmembrane receptor 2", "protein_names_refseq": "lung seven transmembrane receptor 2; protein GPR108 isoform 2 precursor; protein GPR108", "tax_id": 10090, "disease": "", "pathway": " (mmu:78308)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17454009;30332431;31784416;34428180;37330913", "class_list": "", "function": "(Microbial infection) Plays an essential function in adeno-associated virus (AAV) transduction, across multiple serotypes except AAV5. May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus., [UniProtKB, PubMed]; A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity., [RefSeq, PubMed]; GPR108, an NF-kappaB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response., [UniProtKB, PubMed]; Murine Gpr108 gene is located at 17C-D and spans 12.8 kb; Gpr108 cDNA encodes a 562 residue protein that has 49% identity to human GPR107.[Gpr108 protein], [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXE9;Q925B1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005802 trans-Golgi network;GO:0033106 cis-Golgi network membrane", "go_biological_process": "GO:0051607 defense response to virus;GO:0050776 regulation of immune response;GO:0060337 type I interferon-mediated signaling pathway;GO:0030163 protein catabolic process;GO:0034122 negative regulation of toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91WD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WR8-1", "uniprot_id": "GPX6_MOUSE", "mass": 24903.0, "length": 221, "protein_name": "Glutathione peroxidase 6", "gene_name": "Gpx6", "organism": "Mouse", "refseq_name": "glutathione peroxidase 6 precursor", "refseq_ac": "NP_663426", "gene_names_uniprotkb": "Gpx6", "gene_names_refseq": "1700020G18Rik; Gpx6; Ry2d1; olfactory", "protein_names_uniprotkb": "Glutathione peroxidase 6; 1.11.1.9; GPx-6; GSHPx-6", "protein_names_refseq": "GPx-6; GSHPx-6; glutathione peroxidase 6 precursor; odorant-metabolizing protein RY2D1", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:75512); (R-MMU-3299685)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "25535386", "class_list": "", "function": "Overexpression of Gpx6 can dramatically alleviate both behavioral and molecular phenotypes associated with a mouse model of Huntington's disease., [RefSeq, PubMed]; This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidases catalyze the reduction of a variety of hydroperoxides using glutathione as a specific electron donor substrate, and thereby protect cells against oxidative damage. Expression of this gene is restricted to embryos and adult olfactory epithelium. The mouse and rat orthologs contain a cysteine (Cys) residue at the active site, unlike the human counterpart, which is a selenoprotein, containing selenocysteine (Sec) instead. [provided by RefSeq, Jul 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F2Z3U8", "ec_number_list": "1.11.1.12;1.11.1.9;1.11.1.27;1.16.3.1;1.16.3.4", "go_molecular_function": "GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91WR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925Q5-1", "uniprot_id": "GPHA2_MOUSE", "mass": 14030.0, "length": 128, "protein_name": "Glycoprotein hormone alpha-2", "gene_name": "Gpha2", "organism": "Mouse", "refseq_name": "glycoprotein hormone alpha-2 precursor", "refseq_ac": "NP_569720", "gene_names_uniprotkb": "Gpha2; Gpa2; Zsig51", "gene_names_refseq": "GPA2; Gpha2; zsig51", "protein_names_uniprotkb": "Glycoprotein hormone alpha-2; Putative secreted protein Zsig51; Thyrostimulin subunit alpha", "protein_names_refseq": "glycoprotein hormone alpha-2 precursor; putative secreted protein Zsig51; thyrostimulin subunit alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:170458); (R-MMU-375281); (R-MMU-418555)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "26018249", "class_list": "", "function": "Expressed in newborn skulls and long bones but declined rapidly thereafter Erratum:[Endocrinology. 2018 Apr 1;159(4):1762. doi: 10.1210/en.2018-00190. PMID: 29529189], [RefSeq, PubMed]; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005179 hormone activity;GO:0031531 thyrotropin-releasing hormone receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q925Q5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LJ6-1", "uniprot_id": "GPX7_MOUSE", "mass": 21061.0, "length": 186, "protein_name": "Protein peroxidase GPX7", "gene_name": "Gpx7", "organism": "Mouse", "refseq_name": "glutathione peroxidase 7 precursor", "refseq_ac": "NP_077160", "gene_names_uniprotkb": "Gpx7", "gene_names_refseq": "3110050F08Rik; GPX6; Gpx7", "protein_names_uniprotkb": "Protein peroxidase GPX7; 5.3.4.1; GPx-7; GSHPx-7", "protein_names_refseq": "GPx-7; GSHPx-7; glutathione peroxidase 7 precursor", "tax_id": 10090, "disease": "Barrett's adenocarcinoma (Disease Ontology:DOID:7941); Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (mmu:67305); (R-MMU-3299685)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;23123197;23454490;23828861;32317079;34626080", "class_list": "", "function": "Acts as an endoplasmic reticulum (ER) thiol peroxidase that maintains ER redox homeostasis and supports oxidative protein folding. Rapidly reacts with hydrogen peroxide to form sulfenylated/disulfide intermediates and oxidizes protein disulfide isomerase (PDI) family members, promoting disulfide-bond formation. Functions in a redox relay with ERO1A, using ERO1A-generated H(2)O(2) to drive PDI oxidation, linking peroxide detoxification to productive disulfide formation. Protects esophageal epithelia from hydrogen peroxide-induced oxidative stress by reducing reactive oxygen species (ROS) and preventing oxidative DNA damage and double-strand breaks., [UniProtKB, UniProtKB]; GPX7 Facilitates BMSCs Osteoblastogenesis via ER Stress and mTOR Pathway., [RefSeq, PubMed]; GPx7 ameliorates non-alcoholic steatohepatitis by regulating oxidative stress., [RefSeq, PubMed]; GPx7 is an unusual CysGPx catalyzing the peroxidatic cycle by a one Cys mechanism in which GSH and PDI are alternative substrates., [RefSeq, PubMed]; NPGPx is essential for releasing excessive ER stress by enhancing GRP78 chaperone activity to maintain physiological homeostasis., [RefSeq, PubMed]; NPGPx protects against fat accumulation in mice and human via modulating ROS, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.3.4.1;1.8.3.2", "go_molecular_function": "GO:0004096 catalase activity;GO:0004601 peroxidase activity;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99LJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ35-1", "uniprot_id": "GRPL2_MOUSE", "mass": 37784.0, "length": 332, "protein_name": "GLIPR1-like protein 2", "gene_name": "Glipr1l2", "organism": "Mouse", "refseq_name": "GLIPR1-like protein 2 isoform 2", "refseq_ac": "NP_001334086", "gene_names_uniprotkb": "Glipr1l2", "gene_names_refseq": "4921508O11Rik; Glipr1l2", "protein_names_uniprotkb": "GLIPR1-like protein 2", "protein_names_refseq": "GLIPR1-like protein 2 isoform 2; GLIPR1-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67537)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17054904", "class_list": "", "function": "This growth inhibition is partially rescued by expression of ectopic Gli1, suggesting that Fu may contribute to enhance Hh signaling activity in cancer cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q148R1;Q3TTM5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQ35-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9Z7-1", "uniprot_id": "H2BL1_MOUSE", "mass": 14197.0, "length": 123, "protein_name": "Histone H2B variant L1", "gene_name": "H2bl1", "organism": "Mouse", "refseq_name": "histone H2B variant L1", "refseq_ac": "NP_081340", "gene_names_uniprotkb": "H2bl1; SubH2Bv", "gene_names_refseq": "1700024P04Rik; H2bl1; Subh2bv", "protein_names_uniprotkb": "Histone H2B variant L1; Histone H2B subacrosomal variant", "protein_names_refseq": "histone H2B subacrosomal; histone H2B variant L1; histone variant H2bl1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69382)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11784042;17261847", "class_list": "", "function": "May act as an acrosome-nuclear docking protein in sperm., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D9Z7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQQ4-1", "uniprot_id": "GPR45_MOUSE", "mass": 42358.0, "length": 373, "protein_name": "Protein carrier GPR45", "gene_name": "Gpr45", "organism": "Mouse", "refseq_name": "probable G-protein coupled receptor 45", "refseq_ac": "NP_444337", "gene_names_uniprotkb": "Gpr45", "gene_names_refseq": "9230112G11Rik; Gpr45; PSP24-1; PSP24-alpha", "protein_names_uniprotkb": "Protein carrier GPR45; G protein-coupled receptor 45; PSP24-1; PSP24-alpha", "protein_names_refseq": "probable G-protein coupled receptor 45", "tax_id": 10090, "disease": "", "pathway": " (mmu:93690); (R-MMU-418555)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11027574;22262891;27500489;31219806;35820727;40449730;40472089", "class_list": "", "function": "GPR45 is a regulator of POMC signaling and energy expenditure, which suggests that it may be a potential intervention target to combat obesity, [RefSeq, PubMed]; Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation, [RefSeq, PubMed]; Protein carrier that acts as a regulator of food intake in the paraventricular nucleus of the hypothalamus (PVH) by mediating transport of G(s) into primary cilia (PubMed:40472089). Transported into primary cilia of PVH neurons via its association with TULP3 and carries G(s) into the primary cilia to support MC4R activity and activate ADCY3, leading to cAMP production, which signals to suppress appetite (PubMed:40472089). Does not act as a canonical G protein-coupled receptor: does not promote the exchange of GDP for GTP on G(s) protein but mediates G(s) translocation into primary cilia (PubMed:40472089)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0016020 membrane;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0097499 protein localization to non-motile cilium;GO:0032099 negative regulation of appetite", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EQQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYK5-1", "uniprot_id": "H6ST1_MOUSE", "mass": 48302.0, "length": 411, "protein_name": "Heparan-sulfate 6-O-sulfotransferase 1", "gene_name": "Hs6st1", "organism": "Mouse", "refseq_name": "heparan-sulfate 6-O-sulfotransferase 1", "refseq_ac": "NP_056633", "gene_names_uniprotkb": "Hs6st1", "gene_names_refseq": "6Ost1; Hs6st1", "protein_names_uniprotkb": "Heparan-sulfate 6-O-sulfotransferase 1; 2.8.2.-; HS6ST-1; mHS6ST-1", "protein_names_refseq": "HS6ST-1; heparan-sulfate 6-O-sulfotransferase 1; mHS6ST-1", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 15 with or without anosmia (Disease Ontology:DOID:0090075)", "pathway": " (mmu:50785); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10644753;17405882;18196599;30084848;30899004;31219806;34428180;35899427;37828378", "class_list": "glycogene", "function": "6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid., [UniProtKB, PubMed]; Convergent biological pathways underlying the Kallmann syndrome-linked genes Hs6st1 and Fgfr1., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 9, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TK52;Q3TKK0;Q3TND4;Q3TZT5", "ec_number_list": "2.8.2.-", "go_molecular_function": "GO:0017095 heparan sulfate 6-sulfotransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0048286 lung alveolus development;GO:0048666 neuron development;GO:0060716 labyrinthine layer blood vessel development;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9QYK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZF2-1", "uniprot_id": "GPC1_MOUSE", "mass": 61360.0, "length": 557, "protein_name": "Glypican-1", "gene_name": "Gpc1", "organism": "Mouse", "refseq_name": "glypican-1 precursor", "refseq_ac": "NP_057905", "gene_names_uniprotkb": "Gpc1", "gene_names_refseq": "Gpc1", "protein_names_uniprotkb": "Glypican-1", "protein_names_refseq": "glypican-1 precursor", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:14733); (R-MMU-1971475); (R-MMU-2022928); (R-MMU-2024096); (R-MMU-376176); (R-MMU-975634); (R-MMU-9769735); (R-MMU-9769739)", "pathway_count": 8, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11474185;12732622;15677459;16452087;16923158;16971378;18250455;18717736;19656770;19732411;19936054;20100867;21996748;33105135;33300544;36049528;36210013;37828378", "class_list": "glycogene", "function": "Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Binds Cu(2+) or Zn(2+) ions., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Modulation of cardiac voltage-activated K(+) currents by glypican 1 heparan sulfate proteoglycan., [RefSeq, PubMed]; Syndecan-1 and Glypican-1 Knockout Alters Body Water Balance and Urine Response to Fluid Challenge in Mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043236 laminin binding;GO:0005507 copper ion binding;GO:0017134 fibroblast growth factor binding;GO:0070052 collagen V binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005796 Golgi lumen;GO:0005829 cytosol", "go_biological_process": "GO:0016477 cell migration;GO:0014037 Schwann cell differentiation;GO:0032288 myelin assembly;GO:0030200 heparan sulfate proteoglycan catabolic process;GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9QZF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70218-1", "uniprot_id": "HMX1_MOUSE", "mass": 35054.0, "length": 332, "protein_name": "Homeobox protein HMX1", "gene_name": "Hmx1", "organism": "Mouse", "refseq_name": "homeobox protein HMX1 isoform 1", "refseq_ac": "NP_034575", "gene_names_uniprotkb": "Hmx1; H6", "gene_names_refseq": "Hmx1; Nkx5-3", "protein_names_uniprotkb": "Homeobox protein HMX1; Homeobox protein H6", "protein_names_refseq": "H6 homeo box 1; homeobox protein H6; homeobox protein HMX1 isoform 1; homeobox protein HMX1", "tax_id": 10090, "disease": "oculoauricular syndrome (Disease Ontology:DOID:0060482)", "pathway": " (mmu:15371)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;9628823", "class_list": "", "function": "DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O70218-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U2S8-1", "uniprot_id": "HVCN1_MOUSE", "mass": 31242.0, "length": 269, "protein_name": "Voltage-gated hydrogen channel 1", "gene_name": "Hvcn1", "organism": "Mouse", "refseq_name": "voltage-gated hydrogen channel 1", "refseq_ac": "NP_001035954", "gene_names_uniprotkb": "Hvcn1; Bts; Vsop", "gene_names_refseq": "0610039P13Rik; BTS; HV1; Hvcn1; Vsop.; mVSOP", "protein_names_uniprotkb": "Voltage-gated hydrogen channel 1; HV1; Hydrogen voltage-gated channel 1; Voltage sensor domain-only protein; mVSOP", "protein_names_refseq": "voltage sensor domain-only protein; voltage-gated hydrogen channel 1", "tax_id": 10090, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:74096); (R-MMU-1222556); (R-MMU-1300642); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "16075062;16556803;19805063;20026664;21750661;22569364;23165764;24415791;24584463;35377790;35820727;37395288;37669933", "class_list": "", "function": "Expression of Hv1 proton channels in myeloid-derived suppressor cells (MDSC) and its potential role in T cell regulation., [RefSeq, PubMed]; Knockout of microglial Hv1 proton channel reduces neurotoxic A1 astrocytes and neuronal damage via the ROS/STAT3 pathway after spinal cord injury., [RefSeq, PubMed]; Reported that VSOP, a four-transmembrane protein similar to the voltage-sensor domain of voltage-gated ion channels is a voltage-gated proton channel [VSOP], [RefSeq, PubMed]; Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain (PubMed:16556803, PubMed:19805063, PubMed:22569364, PubMed:23165764, PubMed:24584463). Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments, thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst (PubMed:19805063, PubMed:20026664, PubMed:24415791). Opens when the pH of airway surface liquid exceeds 7 and contributes to respiratory epithelial acid secretion to maintain pH in the mucosa (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DCE4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0030171 voltage-gated proton channel activity;GO:0022843 voltage-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0030670 phagocytic vesicle membrane;GO:0036126 sperm flagellum", "go_biological_process": "GO:0010043 response to zinc ion;GO:0032930 positive regulation of superoxide anion generation;GO:0045087 innate immune response;GO:0009268 response to pH;GO:0071467 cellular response to pH", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3U2S8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97292-1", "uniprot_id": "HRH2_MOUSE", "mass": 44794.0, "length": 397, "protein_name": "Histamine H2 receptor", "gene_name": "Hrh2", "organism": "Mouse", "refseq_name": "histamine H2 receptor isoform 1", "refseq_ac": "NP_001010973", "gene_names_uniprotkb": "Hrh2", "gene_names_refseq": "H2R; HH2R; Hrh2", "protein_names_uniprotkb": "Histamine H2 receptor; Gastric receptor I; H2R; HH2R", "protein_names_refseq": "gastric receptor I; histamine H2 receptor isoform 1; histamine H2 receptor", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:15466); (R-MMU-390650); (R-MMU-418555)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10862789;12729842;21750661;32991666;33786748;34105348;36812204;8938453", "class_list": "", "function": "G protein-coupled receptor for histamine, primarily mediating gastric acid secretion. Predominantly expressed in the gastric mucosa, couples to G(s) G alpha proteins upon histamine binding, leading to activation of adenylate cyclase and increased intracellular cyclic AMP (cAMP) levels (By similarity). This signaling cascade stimulates parietal cells to secrete hydrochloric acid, playing a key role in digestive physiology (PubMed:10862789). Also expressed in other tissues, including the heart and central nervous system, where it may contribute to cardiac stimulation and modulate neurotransmitter release (PubMed:12729842)., [UniProtKB, UniProtKB, PubMed, PubMed]; G-protein coupled receptor for histamine, primarily mediating gastric acid secretion. Predominantly expressed in the gastric mucosa, couples to G(s) G alpha proteins upon histamine binding, leading to activation of adenylate cyclase and increased intracellular cyclic AMP (cAMP) levels. This signaling cascade stimulates parietal cells to secrete hydrochloric acid, playing a key role in digestive physiology. Also expressed in other tissues, including the heart and central nervous system, where it may contribute to cardiac stimulation and modulate neurotransmitter release., [UniProtKB, UniProtKB, UniProtKB]; Generation and identification of endothelial-specific Hrh2 knockout mice., [RefSeq, PubMed]; Histamine H2 receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia., [RefSeq, PubMed]; Histamine H2 receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D282", "ec_number_list": "", "go_molecular_function": "GO:0030594 neurotransmitter receptor activity;GO:0004969 histamine receptor activity;GO:1901363 heterocyclic compound binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:1900139 negative regulation of arachidonate secretion;GO:0007613 memory;GO:0008542 visual learning;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97292-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2C8-1", "uniprot_id": "GPAT4_MOUSE", "mass": 52181.0, "length": 456, "protein_name": "Glycerol-3-phosphate acyltransferase 4", "gene_name": "Gpat4", "organism": "Mouse", "refseq_name": "glycerol-3-phosphate acyltransferase 6 precursor", "refseq_ac": "NP_061213", "gene_names_uniprotkb": "Gpat4; Agpat6; Tsarg7", "gene_names_refseq": "Agpat6; Gpat4; Tsarg7", "protein_names_uniprotkb": "Glycerol-3-phosphate acyltransferase 4; 1-AGP acyltransferase 6; 1-AGPAT 6; 1-acylglycerol-3-phosphate O-acyltransferase 6; 2.3.1.15; Acyl-CoA:glycerol-3-phosphate acyltransferase 4; GPAT4; LPAAT-zeta; Lysophosphatidic acid acyltransferase zeta; Testis spermatogenesis apoptosis-related protein 7", "protein_names_refseq": "1-AGP acyltransferase 6; 1-AGPAT 6; 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); LPAAT-zeta; acyl-CoA:glycerol-3-phosphate acyltransferase 4; glycerol-3-phosphate acyltransferase 6 precursor; glycerol-3-phosphate acyltransferase 6; lysophosphatidic acid acyltransferase zeta; putative lysophosphatidic acid acyltransferase; testis spermatogenesis apoptosis-related protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:102247); (R-MMU-1483166)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "15944755;16436371;16449762;18192653;18238778;21750661;22872234;25428506;25428507;27806294;30084848;30523059;31219806;34203471;34428180;36210013", "class_list": "", "function": "'Agpat6(-/-) mice' are actually deficient in a novel NEM-sensitive sn-Glycerol-3-phosphate acyltransferase (GPAT), GPAT4, [RefSeq, PubMed]; Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:18238778). Active against both saturated and unsaturated long-chain fatty acyl-CoAs (By similarity). Protects cells against lipotoxicity (By similarity)., [UniProtKB, PubMed, UniProtKB]; Expression in testis increased steadily with spermatogenesis & sexual maturation. It may play an important role in spermatogenesis & development of cryptorchid testes, & is testis-specific apoptosis candidate oncogene, [RefSeq, PubMed]; Glycerolipid synthesis is induced during macrophage activation. GPAT4 protein level and GPAT3/GPAT4 enzymatic activity increase during this process, and these two isoforms were required for the accumulation of cell TAG and PL. Publication Status: Online-Only, [RefSeq, PubMed]; Results identify a novel glycerolipid acyltransferase of the endoplasmic reticulum, AGPAT6, which is crucial for the production of milk fat by the mammary gland., [RefSeq, PubMed]; Results show that Agpat6 plays a unique role in determining triglyceride content and composition in adipose tissue and liver that cannot be compensated by other members of the Agpat family., [RefSeq, PubMed]; These data identify SEIPIN as an evolutionarily conserved regulator of microsomal GPAT., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TF78;Q5QHR4", "ec_number_list": "2.3.1.51;2.3.1.15;2.3.1.23;2.3.1.67;2.3.1.25;2.3.1.-;2.3.1.121;2.3.1.n6;2.3.1.n7", "go_molecular_function": "GO:0004366 glycerol-3-phosphate O-acyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0002071 glandular epithelial cell maturation;GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0006641 triglyceride metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8K2C8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61657-1", "uniprot_id": "HES3_MOUSE", "mass": 19294.0, "length": 175, "protein_name": "Transcription factor HES-3", "gene_name": "Hes3", "organism": "Mouse", "refseq_name": "transcription factor HES-3", "refseq_ac": "NP_032263", "gene_names_uniprotkb": "Hes3; Hes-3", "gene_names_refseq": "Hes-3; Hes3; bHLHb43", "protein_names_uniprotkb": "Transcription factor HES-3; Hairy and enhancer of split 3", "protein_names_refseq": "hairy and enhancer of split 3; transcription factor HES-3", "tax_id": 10090, "disease": "central nervous system cancer (Disease Ontology:DOID:3620)", "pathway": " (mmu:15207)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;8074710", "class_list": "", "function": "Transcriptional repressor of genes that require a bHLH protein for their transcription., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09083;O09150;Q8BTI2", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021555 midbrain-hindbrain boundary morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q61657-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9QAM5-1", "uniprot_id": "HELZ2_MOUSE", "mass": 331563.0, "length": 2947, "protein_name": "3'-5' exoribonuclease HELZ2", "gene_name": "Helz2", "organism": "Mouse", "refseq_name": "3'-5' exoribonuclease HELZ2", "refseq_ac": "NP_898985", "gene_names_uniprotkb": "Helz2; BC006779", "gene_names_refseq": "Helz2; PDIP1; Pric285; mKIAA1769; mPDIP1", "protein_names_uniprotkb": "3'-5' exoribonuclease HELZ2; 3.1.13.1; 5.6.2.6; ATP-dependent RNA helicase PRIC285; PDIP1; PPAR-gamma DBD-interacting protein 1; PPAR-gamma DNA-binding domain-interacting protein 1", "protein_names_refseq": "3'-5' exoribonuclease HELZ2; ATP-dependent RNA helicase PRIC285; PPAR gamma-DNA-binding domain interacting protein1; PPAR-gamma DBD-interacting protein 1; PPAR-gamma DNA-binding domain-interacting protein 1; helicase with zinc finger domain 2; peroxisomal proliferator-activated receptor A interacting complex 285", "tax_id": 10090, "disease": "", "pathway": " (mmu:229003); (R-MMU-400206); (R-MMU-9707564)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "16239304;21750661;23525231;24129315;25004093;25428506;27802388;34052659;34428180;35820727;41446920", "class_list": "", "function": "Can degrade highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities. Shows a strong preference for pyrimidine over purine residues for its nuclease activity. Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA., [UniProtKB, UniProtKB, UniProtKB]; Expression of Lepr in the liver, but not in the hypothalamus, was up-regulated in Helz2 knockout mice., [RefSeq, PubMed]; Multifunctional nuclear protein involved in RNA surveillance, nuclear receptor-mediated transcriptional regulation, and the restriction of mobile genetic elements as part of the innate immune response. Degrades highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities. Shows a strong preference for pyrimidine over purine residues for its nuclease activity. Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. In addition, regulates lipid metabolism independently of PPARs by controlling the stability of Apob mRNA, which encodes a protein essential for lipoprotein assembly and secretion. Also contributes to adipocyte differentiation through interactions with the splicing factor proline- and glutamine-rich protein SFPQ and THRAP3 (PubMed:23525231, PubMed:41446920)., [UniProtKB, PubMed, UniProtKB, PubMed]; SFPQ associated with a co-activator for PPARgamma, HELZ2, regulates key nuclear factors for adipocyte differentiation., [RefSeq, PubMed]; Thrap3 could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARgamma-mediated gene activation cooperatively with Helz2., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B9A0U1", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;2.3.1.48;2.3.1.-;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.5.1.-;3.5.1.98;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;2.7.11.22;2.7.11.23;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3;2.1.1.-;2.1.1.319", "go_molecular_function": "GO:0008859 exoribonuclease II activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043186 P granule", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "E9QAM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1B212-1", "uniprot_id": "H60B_MOUSE", "mass": 28224.0, "length": 251, "protein_name": "Histocompatibility antigen 60b", "gene_name": "H60b", "organism": "Mouse", "refseq_name": "histocompatibility antigen 60b precursor", "refseq_ac": "NP_001171246", "gene_names_uniprotkb": "H60b", "gene_names_refseq": "EG667281; H60b", "protein_names_uniprotkb": "Histocompatibility antigen 60b", "protein_names_refseq": "histocompatibility antigen 60b precursor; histocompatibility antigen 60b", "tax_id": 10090, "disease": "", "pathway": " (mmu:667281)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;18209064", "class_list": "", "function": "Identified two novel mouse chromosome 10-encoded NKG2D ligands, H60b and H60c, structurally resembling H60., [RefSeq, PubMed]; Ligand for the KLRK1 immunosurveillance receptor. Binding to KLRK1 stimulates cell lysis in vitro., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0042267 natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B1B212-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HKE5-1", "uniprot_id": "H2A1G_MOUSE", "mass": 14135.0, "length": 130, "protein_name": "Histone H2A type 1-G", "gene_name": "H2ac11", "organism": "Mouse", "refseq_name": "histone H2A type 1-G", "refseq_ac": "NP_835493", "gene_names_uniprotkb": "H2ac11; Hist1h2ag", "gene_names_refseq": "H2ac11; Hist1h2ag", "protein_names_uniprotkb": "Histone H2A type 1-G", "protein_names_refseq": "histone 1, H2ag; histone H2A type 1-G; histone H2A type 1; histone cluster 1, H2ag", "tax_id": 10090, "disease": "", "pathway": " (mmu:319164); (mmu:319165); (mmu:319166); (mmu:319167); (mmu:319170); (mmu:319171); (mmu:319172); (mmu:319191); (mmu:665433); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 26, "publication_count": 10, "publication_id_list": "12408966;15509584;15525528;16699504;21925322;24352239;24681537;27105115;30154464;7217105", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10812;P22752;Q149U0;Q5SZZ2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "C0HKE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HKE7-1", "uniprot_id": "H2A1N_MOUSE", "mass": 14135.0, "length": 130, "protein_name": "Histone H2A type 1-N", "gene_name": "Hist1h2an", "organism": "Mouse", "refseq_name": "histone H2A type 1-N", "refseq_ac": "NP_835491", "gene_names_uniprotkb": "Hist1h2an", "gene_names_refseq": "H2ac22; Hist1h2an", "protein_names_uniprotkb": "Histone H2A type 1-N", "protein_names_refseq": "histone 1, H2an; histone H2A type 1-N; histone H2A type 1; histone cluster 1, H2an", "tax_id": 10090, "disease": "", "pathway": " (mmu:319164); (mmu:319165); (mmu:319166); (mmu:319167); (mmu:319170); (mmu:319171); (mmu:319172); (mmu:319191); (mmu:665433); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 26, "publication_count": 10, "publication_id_list": "12408966;15509584;15525528;16699504;21925322;24352239;24681537;27105115;30154464;7217105", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10812;P22752;Q149U0;Q5SZZ2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "C0HKE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HKE8-1", "uniprot_id": "H2A1O_MOUSE", "mass": 14135.0, "length": 130, "protein_name": "Histone H2A type 1-O", "gene_name": "Hist1h2ao", "organism": "Mouse", "refseq_name": "histone H2A type 1-O", "refseq_ac": "NP_001171015", "gene_names_uniprotkb": "Hist1h2ao", "gene_names_refseq": "H2ac23; Hist1h2ao; Hist1h2ap", "protein_names_uniprotkb": "Histone H2A type 1-O", "protein_names_refseq": "Histone H2A type 1-P; histone H2A type 1-O; histone H2A type 1; histone cluster 1, H2ao", "tax_id": 10090, "disease": "", "pathway": " (mmu:319164); (mmu:319165); (mmu:319166); (mmu:319167); (mmu:319170); (mmu:319171); (mmu:319172); (mmu:319191); (mmu:665433); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 26, "publication_count": 11, "publication_id_list": "12408966;15509584;15525528;16699504;1971418;21925322;24352239;24681537;27105115;30154464;7217105", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10812;P22752;Q149U0;Q5SZZ2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "C0HKE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z7H4-1", "uniprot_id": "GSG1L_MOUSE", "mass": 35889.0, "length": 322, "protein_name": "Germ cell-specific gene 1-like protein", "gene_name": "Gsg1l", "organism": "Mouse", "refseq_name": "germ cell-specific gene 1-like protein isoform 1", "refseq_ac": "NP_001094958", "gene_names_uniprotkb": "Gsg1l", "gene_names_refseq": "C230098I05Rik; G630023A01Rik; Gm637; Gsg1l; g1l", "protein_names_uniprotkb": "Germ cell-specific gene 1-like protein; GSG1-like protein", "protein_names_refseq": "GSG1-like protein; germ cell-specific gene 1-like protein isoform 1; germ cell-specific gene 1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:269994)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22632720;32697982", "class_list": "", "function": "AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility. Erratum:[Cell Rep. 2021 Feb 16;34(7):108732. doi: 10.1016/j.celrep.2021.108732. PMID: 33596427], [RefSeq, PubMed]; As a component of the inner core of AMPAR complexes, modifies AMPA receptor (AMPAR) gating., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0032279 asymmetric synapse;GO:0098839 postsynaptic density membrane;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0050808 synapse organization;GO:0019226 transmission of nerve impulse;GO:2000311 regulation of AMPA receptor activity;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z7H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P3E7-1", "uniprot_id": "HDA10_MOUSE", "mass": 72109.0, "length": 666, "protein_name": "Polyamine deacetylase HDAC10", "gene_name": "Hdac10", "organism": "Mouse", "refseq_name": "polyamine deacetylase HDAC10 isoform 1", "refseq_ac": "NP_954668", "gene_names_uniprotkb": "Hdac10", "gene_names_refseq": "Hd10; Hdac10", "protein_names_uniprotkb": "Polyamine deacetylase HDAC10; 3.5.1.48; 3.5.1.62; HD10; Histone deacetylase 10", "protein_names_refseq": "polyamine deacetylase HDAC10 isoform 1; polyamine deacetylase HDAC10", "tax_id": 10090, "disease": "", "pathway": " (mmu:170787); (R-MMU-350054)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11677242;21750661;36538592;38956592", "class_list": "", "function": "Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses., [RefSeq, PubMed]; Myeloid-specific Hdac10 deletion protects against LPS-induced acute lung injury via P62 acetylation at lysine 165. Publication Status: Online-Only, [RefSeq, PubMed]; Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3X9I8", "ec_number_list": "3.5.1.-;3.5.1.98;3.5.1.48;3.5.1.62", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042826 histone deacetylase binding;GO:0019213 deacetylase activity;GO:0004407 histone deacetylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0032425 positive regulation of mismatch repair;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006355 regulation of DNA-templated transcription;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P3E7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61645-1", "uniprot_id": "HAIR_MOUSE", "mass": 127193.0, "length": 1182, "protein_name": "Lysine-specific demethylase hairless", "gene_name": "Hr", "organism": "Mouse", "refseq_name": "lysine-specific demethylase hairless", "refseq_ac": "NP_068677", "gene_names_uniprotkb": "Hr", "gene_names_refseq": "ALUNC; Hr; bldy; rh-bmh", "protein_names_uniprotkb": "Lysine-specific demethylase hairless; 1.14.11.65; [histone H3]-dimethyl-L-lysine(9) demethylase hairless", "protein_names_refseq": "[histone H3]-dimethyl-L-lysine(9) demethylase hairless; lysine demethylase and nuclear receptor corepressor; lysine-specific demethylase hairless; protein hairless", "tax_id": 10090, "disease": "alopecia universalis (Disease Ontology:DOID:0050634); atrichia with papular lesions (Disease Ontology:DOID:0060689); hypotrichosis 4 (Disease Ontology:DOID:0110701); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); alcohol use disorder (Disease Ontology:DOID:1574); proteinuria (Disease Ontology:DOID:576); alopecia (Disease Ontology:DOID:987)", "pathway": " (mmu:15460)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;8052649", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code., [UniProtKB, UniProtKB]; Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory ORF that exists upstream of the primary ORF. Mutations in this upstream ORF, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss in human. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y47", "ec_number_list": "1.14.11.65;1.14.11.-;1.14.99.66", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0044877 protein-containing complex binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0070988 demethylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q61645-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43120-1", "uniprot_id": "HHEX_MOUSE", "mass": 29987.0, "length": 271, "protein_name": "Hematopoietically-expressed homeobox protein Hhex", "gene_name": "Hhex", "organism": "Mouse", "refseq_name": "hematopoietically-expressed homeobox protein Hhex", "refseq_ac": "NP_032271", "gene_names_uniprotkb": "Hhex; Prhx; Prh", "gene_names_refseq": "Hex1; Hex; Hhex-rs2; Hhex; Prhx; Prh", "protein_names_uniprotkb": "Hematopoietically-expressed homeobox protein Hhex; Homeobox protein HEX; Homeobox protein PRH; Proline-rich homeodomain protein; mHex", "protein_names_refseq": "hematopoietically expressed homeobox, related sequence 2; hematopoietically-expressed homeobox protein Hhex; homeobox protein HEX; homeobox protein PRH; mHex; proline-rich homeodomain protein", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:15242)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10101294;10501975;10804173;12554669;16936074;20028982;21750661;23665349;34428180;8096636", "class_list": "", "function": "Recognizes the DNA sequence 5'-ATTAA-3' (PubMed:10804173). Transcriptional repressor (PubMed:10804173). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:16936074). Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (PubMed:16936074). Inhibits EIF4E-mediated mRNA nuclear export (By similarity). May play a role in hematopoietic differentiation (PubMed:8096636)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q544N6;Q9CRV1;Q9R1X2", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0030878 thyroid gland development;GO:0002573 myeloid leukocyte differentiation;GO:0060431 primary lung bud formation;GO:0061010 gallbladder development;GO:0061011 hepatic duct development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P43120-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08755-1", "uniprot_id": "HNF6_MOUSE", "mass": 50952.0, "length": 465, "protein_name": "Hepatocyte nuclear factor 6", "gene_name": "Onecut1", "organism": "Mouse", "refseq_name": "hepatocyte nuclear factor 6", "refseq_ac": "NP_032288", "gene_names_uniprotkb": "Onecut1; Hnf6a; Hnf6", "gene_names_refseq": "D9Ertd423e; HNF-6; Hfh12; Hnf6b; Hnf6; OC-1; Oc1; Onecut1", "protein_names_uniprotkb": "Hepatocyte nuclear factor 6; HNF-6; One cut domain family member 1; One cut homeobox 1", "protein_names_refseq": "HNF-3/forkhead homolog 12; hepatic nuclear factor 6; hepatocyte nuclear factor 6; one cut homeobox 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15379)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15169783;15381696;20485683;40997131;9441664", "class_list": "", "function": "Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. 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"reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O08755-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01747-1", "uniprot_id": "HVM03_MOUSE", "mass": 13307.0, "length": 120, "protein_name": "Ig heavy chain V region 36-65", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region 36-65", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "11673524;6186498", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 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0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01748-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01750-1", "uniprot_id": "HVM06_MOUSE", "mass": 12867.0, "length": 117, "protein_name": "Ig heavy chain V region 102", 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They compact sperm DNA into a highly condensed, stable and inactive complex., [UniProtKB]; Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000786 nucleosome", "go_biological_process": "GO:0007286 spermatid development;GO:0030261 chromosome condensation;GO:0006997 nucleus organization;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P02319-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04219-1", "uniprot_id": "HYIG_MOUSE", "mass": 15424.0, "length": 140, "protein_name": "Putative uncharacterized Ig-region protein", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative uncharacterized Ig-region protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "35820727;6417547", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P04219-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06328-1", "uniprot_id": "HVM49_MOUSE", "mass": 12877.0, "length": 117, "protein_name": "Ig heavy chain V region 1-72", "gene_name": "Ighv1-72", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ighv1-72", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region 1-72; Ig heavy chain V region VH558 B4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); (R-MMU-198933); (R-MMU-202733); (R-MMU-2029481); (R-MMU-2029482); (R-MMU-2029485); (R-MMU-2168880); (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837); (R-MMU-5690714); (R-MMU-977606); (R-MMU-983695)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "2578321", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A075B5X9", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P06328-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06329-1", "uniprot_id": "HVM50_MOUSE", "mass": 13311.0, "length": 120, "protein_name": "Ig heavy chain V region AC38 15.3", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region AC38 15.3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6201362", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P06329-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08882-1", "uniprot_id": "GRAC_MOUSE", "mass": 27311.0, "length": 248, "protein_name": "Granzyme C", "gene_name": "Gzmc", "organism": "Mouse", "refseq_name": "granzyme C preproprotein", "refseq_ac": "NP_034501", "gene_names_uniprotkb": "Gzmc; Ctla-5; Ctla5", "gene_names_refseq": "B10; CCP2; Ctla-5; Ctla5; Gzmc", "protein_names_uniprotkb": "Granzyme C; 3.4.21.-; B10; CCP2; Cytotoxic cell protease 2", "protein_names_refseq": "cytotoxic cell protease 2; granzyme C preproprotein", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); bronchiolitis obliterans (Disease Ontology:DOID:2799); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:14940)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "3257230;3264185;3292281;3518058;3555842", "class_list": "", "function": "Serine protease probably necessary for target cell lysis in cell-mediated immune responses., [UniProtKB, PubMed, PubMed]; This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product, expressed by activated T cells, may induce apoptosis of target cells. This gene is present in a gene cluster with other members of the granzyme subfamily on chromosome 14. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61389", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0044194 cytolytic granule", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0046513 ceramide biosynthetic process;GO:0017148 negative regulation of translation;GO:0031640 killing of cells of another organism;GO:0070269 pyroptotic inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P08882-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10922-1", "uniprot_id": "H10_MOUSE", "mass": 20861.0, "length": 194, "protein_name": "Histone H1.0", "gene_name": "H1-0", "organism": "Mouse", "refseq_name": "histone H1.0", "refseq_ac": "NP_032223", "gene_names_uniprotkb": "H1-0; H1f0; H1fv", "gene_names_refseq": "D130017D06Rik; H1(0); H1-0; H1f0; H1fv", "protein_names_uniprotkb": "Histone H1.0; Histone H1'; Histone H1(0); MyD196", "protein_names_refseq": "H1 histone family, member 0; H1-0 histone; histone H1'; histone H1(0); histone H1.0; myD196", "tax_id": 10090, "disease": "", "pathway": " (mmu:14958); (R-MMU-140342); (R-MMU-2559584)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;1690380;2846273;31219806;31599954;32512172;33299181;33300544;33725478;34428180;36210013;36288343;36928068;37453647;37507081;39927985;7891682", "class_list": "", "function": "Computation of FRAP recovery times for linker histone - chromatin binding on the basis of Brownian dynamics simulations., [RefSeq, PubMed]; Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture., [RefSeq, PubMed]; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division., [UniProtKB, UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]., [RefSeq]; Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKC0", "ec_number_list": "", "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003677 DNA binding;GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex;GO:0016604 nuclear body;GO:0000791 euchromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P10922-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11032-1", "uniprot_id": "GRAA_MOUSE", "mass": 28599.0, "length": 260, "protein_name": "Granzyme A", "gene_name": "Gzma", "organism": "Mouse", "refseq_name": "granzyme A precursor", "refseq_ac": "NP_034500", "gene_names_uniprotkb": "Gzma; Ctla-3; Ctla3; Mtsp-1", "gene_names_refseq": "Ctla-3; Ctla3; Gzma; Hf1; Hf; SE1; TSP-1; TSP1", "protein_names_uniprotkb": "Granzyme A; 3.4.21.78; Autocrine thymic lymphoma granzyme-like serine protease; CTLA-3; Fragmentin-1; T cell-specific serine protease 1; TSP-1", "protein_names_refseq": "BLT esterase; H factor; Hanukah factor; autocrine thymic lymphoma granzyme-like serine protease; fragmentin-1; granzyme A precursor; serine esterase 1; t cell-specific serine protease 1", "tax_id": 10090, "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:14938)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;1460043;1639378;2422755;28011936;2976140;3260181;3292396;3533635;3555842;37462629;37624843", "class_list": "", "function": "Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3555842). It cleaves after Lys or Arg (By similarity). Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity (By similarity). Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity)., [UniProtKB, PubMed, UniProtKB]; Granzyme-A deficiency attenuates experimental osteoarthritis in mice, but perforin deficiency does not. Publication Status: Online-Only, [RefSeq, PubMed]; Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic beta cells resulting in neonatal lethality. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P15118", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042803 protein homodimerization activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0044194 cytolytic granule", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0009617 response to bacterium;GO:0031640 killing of cells of another organism;GO:0070269 pyroptotic inflammatory response;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P11032-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12850-1", "uniprot_id": "GROA_MOUSE", "mass": 10254.0, "length": 96, "protein_name": "Growth-regulated alpha protein", "gene_name": "Cxcl1", "organism": "Mouse", "refseq_name": "growth-regulated alpha protein precursor", "refseq_ac": "NP_032202", "gene_names_uniprotkb": "Cxcl1; Gro1; Gro; Mgsa; Scyb1", "gene_names_refseq": "Cxcl1; Fsp; Gro1; KC; Mgsa; N51; Scyb1; gro", "protein_names_uniprotkb": "Growth-regulated alpha protein; C-X-C motif chemokine 1; HSF; Hematopoietic synergistic factor; KC-T; Platelet-derived growth factor-inducible protein KC; Secretory protein N51", "protein_names_refseq": "C-X-C motif chemokine 1; GRO1 oncogene; KC/GR)-alpha; KC/GRO-alpha; alpha-chemokine; chemokine (C-X-C motif) ligand 1; growth-regulated alpha protein precursor; growth-regulated alpha protein; platelet-derived growth factor-inducible protein KC; secretory protein N51", "tax_id": 10090, "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); stroke (Disease Ontology:DOID:0051061); alcohol-associated liver disease (Disease Ontology:DOID:0070658); COVID-19 (Disease Ontology:DOID:0080600); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); common cold (Disease Ontology:DOID:10459); viral pneumonia (Disease Ontology:DOID:10533); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); dilated cardiomyopathy (Disease Ontology:DOID:12930); interstitial cystitis (Disease Ontology:DOID:13949); prostatitis (Disease Ontology:DOID:14654); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); esophageal cancer (Disease Ontology:DOID:5041); pneumonia (Disease Ontology:DOID:552); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (mmu:14825); (R-MMU-380108); (R-MMU-418594); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10725737;15183770;22379035;2909392;2917992;7561058", "class_list": "", "function": "CXCL1 controls neutrophil recruitment and regulates the expression of NADPH oxidase, iNOS & LTB4 in the lungs after K. pneumoniae infection., [RefSeq, PubMed]; Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity., [UniProtKB, PubMed]; This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032930 positive regulation of superoxide anion generation;GO:0043268 positive regulation of potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P12850-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14602-1", "uniprot_id": "HSPB1_MOUSE", "mass": 23014.0, "length": 209, "protein_name": "Heat shock protein beta-1", "gene_name": "Hspb1", "organism": "Mouse", "refseq_name": "heat shock protein beta-1", "refseq_ac": "NP_038588", "gene_names_uniprotkb": "Hspb1; Hsp25; Hsp27", "gene_names_refseq": "27kDa; Hsp25; Hspb1", "protein_names_uniprotkb": "Heat shock protein beta-1; Growth-related 25 kDa protein; HSP 25; HSP 27; Heat shock 25 kDa protein; Heat shock 27 kDa protein; HspB1; p25", "protein_names_refseq": "HSP 25; HSP 27; growth-related 25 kDa protein; heat shock 25 kDa protein; heat shock 27 kDa protein; heat shock 27kDa protein 1; heat shock protein 1; heat shock protein beta-1; heat shock protein, 25 kDa; p25", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease axonal type 2F (Disease Ontology:DOID:0110163); autosomal dominant distal hereditary motor neuronopathy 3 (Disease Ontology:DOID:0111207); Alzheimer's disease (Disease Ontology:DOID:10652); sarcoma (Disease Ontology:DOID:1115); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:15507); (R-MMU-4420097); (R-MMU-450408); (R-MMU-5687128); (R-MMU-9009391)", "pathway_count": 5, "publication_count": 37, "publication_id_list": "10751411;11342557;11546764;1332886;17242355;17661394;1860870;21183079;21575178;21750661;22065986;23372691;24129315;2645135;27152617;27375022;28011936;28528544;28768826;30016717;31219806;32782141;34428180;35822049;36288343;36852467;37453647;37507081;38481805;39927985;40021952;40885482;8093612;8132504;8514193;8514194;9620170", "class_list": "", "function": "Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1. Publication Status: Online-Only, [RefSeq, PubMed]; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization (PubMed:17661394). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051082 unfolded protein binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0099641 anterograde axonal protein transport;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0010976 positive regulation of neuron projection development;GO:0035556 intracellular signal transduction;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P14602-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18528-1", "uniprot_id": "HVM57_MOUSE", "mass": 11007.0, "length": 98, "protein_name": "Ig heavy chain V region 6.96", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region 6.96", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2499654;34418053", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P18528-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18529-1", "uniprot_id": "HVM58_MOUSE", "mass": 12991.0, "length": 117, "protein_name": "Ig heavy chain V region 5-76", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region 5-76", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2499654", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18529-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18532-1", "uniprot_id": "HVM61_MOUSE", "mass": 13158.0, "length": 116, "protein_name": "Ig heavy chain V region 1B43", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region 1B43", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2499654;33725478", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P18532-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29416-1", "uniprot_id": "HEXA_MOUSE", "mass": 60613.0, "length": 528, "protein_name": "Beta-hexosaminidase subunit alpha", "gene_name": "Hexa", "organism": "Mouse", "refseq_name": "beta-hexosaminidase subunit alpha isoform 1 preproprotein", "refseq_ac": "NP_034551", "gene_names_uniprotkb": "Hexa", "gene_names_refseq": "Hex-1; Hexa", "protein_names_uniprotkb": "Beta-hexosaminidase subunit alpha; 3.2.1.52; Beta-N-acetylhexosaminidase subunit alpha; Hexosaminidase subunit A; N-acetyl-beta-glucosaminidase subunit alpha", "protein_names_refseq": "N-acetyl-beta-glucosaminidase subunit alpha; beta-N-acetylhexosaminidase subunit alpha; beta-hexosaminidase subunit alpha isoform 1 preproprotein; beta-hexosaminidase subunit alpha; hexosaminidase subunit A", "tax_id": 10090, "disease": "Tay-Sachs disease (Disease Ontology:DOID:3320)", "pathway": " (mmu:15211); (R-MMU-2022857); (R-MMU-2024101); (R-MMU-2160916); (R-MMU-9840310)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;1379046;25428506;25428507;26740625;27802388;29187734;30084848;30899004;31599954;32152506;34428180;34800307;7833835;7896264;7959736", "class_list": "glycogene;glycosylhydrolase", "function": "Hexosaminidase A (HEXA) regulates hepatic sphingolipid and lipoprotein metabolism in mice., [RefSeq, PubMed]; Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A., [UniProtKB, UniProtKB]; This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mice lacking the encoded protein exhibit accumulation of gangliosides in the brain and membranous cytoplasmic bodies in neurons. Certain mutations in the human ortholog of this gene cause Tay-Sachs disease. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q64246;Q91XG3", "ec_number_list": "3.2.1.52", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0008375 acetylglucosaminyltransferase activity;GO:0004563 beta-N-acetylhexosaminidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0016020 membrane;GO:0005764 lysosome;GO:0042582 azurophil granule", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0030209 dermatan sulfate proteoglycan catabolic process;GO:0007626 locomotory behavior;GO:0050885 neuromuscular process controlling balance;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P29416-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31310-1", "uniprot_id": "HXA10_MOUSE", "mass": 43292.0, "length": 416, "protein_name": "Homeobox protein Hox-A10", "gene_name": "Hoxa10", "organism": "Mouse", "refseq_name": "homeobox protein Hox-A10 isoform b", "refseq_ac": "NP_001116422", "gene_names_uniprotkb": "Hoxa10; Hox-1.8; Hoxa-10", "gene_names_refseq": "Hox-1.8; Hoxa-10; Hoxa10", "protein_names_uniprotkb": "Homeobox protein Hox-A10; Homeobox protein Hox-1.8", "protein_names_refseq": "homeo box A10; homeobox protein Hox-1.8; homeobox protein Hox-A10 isoform b; homeobox protein Hox-A10", "tax_id": 10090, "disease": "", "pathway": " (mmu:15395)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1683707;1720547;38123662;7862151", "class_list": "", "function": "HOXA10 promotes Gdf5 expression in articular chondrocytes. Publication Status: Online-Only, [RefSeq, PubMed]; In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of a cluster on chromosome 6 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y22", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P31310-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43142-1", "uniprot_id": "ACKR5_MOUSE", "mass": 45384.0, "length": 398, "protein_name": "Atypical chemokine receptor 5", "gene_name": "Ackr5", "organism": "Mouse", "refseq_name": "atypical chemokine receptor 5", "refseq_ac": "NP_031438", "gene_names_uniprotkb": "Ackr5; Admr; Gpcr22; Gpr182", "gene_names_refseq": "AM-R; Ackr5; Admr; G10-D; Gpcr17; Gpcr22; Gpr182; MB10; NOW", "protein_names_uniprotkb": "Atypical chemokine receptor 5; G protein-coupled receptor 182; G10D; NOW", "protein_names_refseq": "G10D; adrenomedullin receptor; atypical chemokine receptor 5", "tax_id": 10090, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:11536)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "33875597;35013216;37554323;38026988;8288218", "class_list": "", "function": "Atypical chemokine receptor that regulates chemokine levels and localization through chemokine binding, independently of activating classical ligand-induced signaling pathways such as G protein activation and Ca(2+) mobilization (PubMed:33875597, PubMed:35013216, PubMed:37554323, PubMed:38026988). Instead, it mediates chemokine sequestration, transport, or internalization to control their availability (PubMed:33875597, PubMed:35013216, PubMed:37554323, PubMed:38026988). Acts as a scavenger for a broad range of chemokines from CXC, CC and XC chemokine ligand families including CXCL9, CXCL10, CXCL12, CXCL13, CXCL11, CXCL14, CCL1, CCL11, CCL19, CCL25, CCL28 and CCL22, CCL24 and CCL27 (PubMed:33875597, PubMed:35013216, PubMed:37554323, PubMed:38026988). Is the only atypical receptor for chemokines CXCL13 and CCL28 (PubMed:37554323). Has a strong constitutive association with beta-arrestins, which is essential for intracellular receptor trafficking and chemokine scavenging, and occurs independently of ligand binding (PubMed:37554323). Cooperates with ACKR3 and ACKR4 in regulating serum levels of CXCL12 and CCL19, respectively (PubMed:37554323). Acts as an important modulator of cellular immunity (PubMed:37554323)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3X9R9", "ec_number_list": "", "go_molecular_function": "GO:0019957 C-C chemokine binding;GO:0019958 C-X-C chemokine binding;GO:0001605 adrenomedullin receptor activity;GO:0140319 receptor decoy activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P43142-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43687-1", "uniprot_id": "HMX2_MOUSE", "mass": 29634.0, "length": 273, "protein_name": "Homeobox protein HMX2", "gene_name": "Hmx2", "organism": "Mouse", "refseq_name": "homeobox protein HMX2", "refseq_ac": "NP_666110", "gene_names_uniprotkb": "Hmx2; Nkx-5.2; Nkx5-2", "gene_names_refseq": "Hmx2; Nkx-5.2; Nkx5-2", "protein_names_uniprotkb": "Homeobox protein HMX2; Homeobox protein Nkx-5.2", "protein_names_refseq": "H6 homeo box 2; NK-related homeobox; homeobox protein HMX2; homeobox protein Nkx-5.2", "tax_id": 10090, "disease": "", "pathway": " (mmu:15372)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11748138;15363417;7510254;8541222", "class_list": "", "function": "Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUN6;Q8R1Q2", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P43687-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48794-1", "uniprot_id": "HYALP_MOUSE", "mass": 58498.0, "length": 512, "protein_name": "Hyaluronidase PH-20", "gene_name": "Spam1", "organism": "Mouse", "refseq_name": "hyaluronidase PH-20 precursor", "refseq_ac": "NP_001073344", "gene_names_uniprotkb": "Spam1; Ph20; Spam", "gene_names_refseq": "Ph-20; Spam1", "protein_names_uniprotkb": "Hyaluronidase PH-20; 3.2.1.35; Hyal-PH20; Hyaluronoglucosaminidase PH-20; Sperm adhesion molecule 1; Sperm surface protein PH-20", "protein_names_refseq": "hyal-PH20; hyaluronidase PH-20 precursor; hyaluronidase PH-20; hyaluronoglucosaminidase PH-20; sperm surface protein PH-20", "tax_id": 10090, "disease": "", "pathway": " (mmu:20690)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11845284;12065596;19926939;22362218;23463525;31670981;7794889", "class_list": "glycogene;glycosylhydrolase", "function": "A comparative analysis between WT and Spam1/Hyal5 dKO epididymal sperm revealed that the absence of these 2 sperm Hyals resulted in a marked accumulation of sperm on the outside of the cumulus-oocyte complex., [RefSeq, PubMed]; ACR or PRSS21 or both may function cooperatively with SPAM1 in sperm/cumulus penetration, [RefSeq, PubMed]; Entrapment of spontaneous Spam1 mutations, owing to recombination suppression near the Robertsonion translocation junctions, is proposed as the major underlying defect of the sperm dysfunction., [RefSeq, PubMed]; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid., [UniProtKB]; PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination., [RefSeq, PubMed]; Sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg, [RefSeq, PubMed]; The data from this paper suggests that the hyaluronan-degrading activity of the sperm hyaluronidase SPAM1 may not be required for fertilization, at least in the mouse., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 36, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSD6;Q812F4;Q9DAQ1", "ec_number_list": "", "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007155 cell adhesion;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0005975 carbohydrate metabolic process;GO:0007338 single fertilization;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P48794-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52785-1", "uniprot_id": "GUC2E_MOUSE", "mass": 120638.0, "length": 1108, "protein_name": "Retinal guanylyl cyclase 1", "gene_name": "Gucy2e", "organism": "Mouse", "refseq_name": "retinal guanylyl cyclase 1 precursor", "refseq_ac": "NP_032218", "gene_names_uniprotkb": "Gucy2e; Guc2e", "gene_names_refseq": "GC-E; GC1; Gucy2e; ROS-GC1", "protein_names_uniprotkb": "Retinal guanylyl cyclase 1; 4.6.1.2; Guanylate cyclase 2E; Guanylyl cyclase GC-E", "protein_names_refseq": "guanylyl cyclase 2e; guanylyl cyclase GC-E; retinal guanylyl cyclase 1 precursor; retinal guanylyl cyclase 1", "tax_id": 10090, "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); Leber congenital amaurosis 1 (Disease Ontology:DOID:0110078); cone-rod dystrophy 6 (Disease Ontology:DOID:0111011); retinitis pigmentosa (Disease Ontology:DOID:10584); choroidal sclerosis (Disease Ontology:DOID:980)", "pathway": " (mmu:14919); (R-MMU-2514859)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17255100;21598940;25428506;33171621;8838319", "class_list": "", "function": "Angiotensin II-Induced Cardiovascular Fibrosis Is Attenuated by NO-Sensitive Guanylyl Cyclase1. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:21598940). May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane (PubMed:17255100)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B1ASX7", "ec_number_list": "4.6.1.2", "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0001750 photoreceptor outer segment;GO:0042622 photoreceptor outer segment membrane;GO:0120202 rod photoreceptor disc membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0046068 cGMP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P52785-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84751-1", "uniprot_id": "HVM63_MOUSE", "mass": 25350.0, "length": 237, "protein_name": "Ig heavy chain Mem5", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain Mem5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "12414967;33725478;35984892", "class_list": "", "function": "Anti-influenza H3N2 neuraminidase antibody., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P84751-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06186-1", "uniprot_id": "HBEGF_MOUSE", "mass": 22808.0, "length": 208, "protein_name": "Proheparin-binding EGF-like growth factor", "gene_name": "Hbegf", "organism": "Mouse", "refseq_name": "proheparin-binding EGF-like growth factor precursor", "refseq_ac": "NP_034545", "gene_names_uniprotkb": "Hbegf; Dtr; Hegfl", "gene_names_refseq": "Dtr; Dts; Hbegf; Hegfl", "protein_names_uniprotkb": "Proheparin-binding EGF-like growth factor", "protein_names_refseq": "diphtheria toxin receptor; heparin binding epidermal growth factor-like growth factor; proheparin-binding EGF-like growth factor precursor; proheparin-binding EGF-like growth factor", "tax_id": 10090, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); acute kidney failure (Disease Ontology:DOID:3021); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (mmu:15200); (R-MMU-1227986); (R-MMU-1236394); (R-MMU-1250196); (R-MMU-1250342); (R-MMU-1250347); (R-MMU-1257604); (R-MMU-177929); (R-MMU-179812); (R-MMU-180292); (R-MMU-180336); (R-MMU-182971); (R-MMU-1963640); (R-MMU-1963642); (R-MMU-212718); (R-MMU-2179392); (R-MMU-5673001); (R-MMU-6785631); (R-MMU-6811558); (R-MMU-8847993); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8857538); (R-MMU-8863795); (R-MMU-9009391)", "pathway_count": 25, "publication_count": 5, "publication_id_list": "25428506;38409259;38724220;7678488;8647467", "class_list": "", "function": "Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor., [UniProtKB]; Novel IL-4/HB-EGF-dependent crosstalk between eosinophils and macrophages controls liver regeneration after ischaemia and reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q06186-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14B70-1", "uniprot_id": "HDX_MOUSE", "mass": 76861.0, "length": 692, "protein_name": "Highly divergent homeobox", "gene_name": "Hdx", "organism": "Mouse", "refseq_name": "highly divergent homeobox isoform 1", "refseq_ac": "NP_001074018", "gene_names_uniprotkb": "Hdx", "gene_names_refseq": "D030011N01Rik; Gm380; Hdx", "protein_names_uniprotkb": "Highly divergent homeobox", "protein_names_refseq": "highly divergent homeobox isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:245596)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34678516", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14B69", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q14B70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3THK7-1", "uniprot_id": "GUAA_MOUSE", "mass": 76723.0, "length": 693, "protein_name": "GMP synthase [glutamine-hydrolyzing]", "gene_name": "Gmps", "organism": "Mouse", "refseq_name": "GMP synthase [glutamine-hydrolyzing]", "refseq_ac": "NP_001028472", "gene_names_uniprotkb": "Gmps", "gene_names_refseq": "670032; Gm9479; Gmps", "protein_names_uniprotkb": "GMP synthase [glutamine-hydrolyzing]; 6.3.5.2; GMP synthetase; Glutamine amidotransferase", "protein_names_refseq": "GMP synthase [glutamine-hydrolyzing]; GMP synthase; GMP synthetase; glutamine amidotransferase", "tax_id": 10090, "disease": "acute myelomonocytic leukemia (Disease Ontology:DOID:0081082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:229363); (R-MMU-73817); (R-MMU-9748787)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;22645316;240826;24788674;25153642;28135057;28528544;34428180;35984892;37507081;39627609", "class_list": "", "function": "Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFR6;Q3TIH1;Q3UJ21;Q3V343;Q66JZ6", "ec_number_list": "6.3.5.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0003921 GMP synthase activity;GO:0003922 GMP synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006177 GMP biosynthetic process;GO:1901367 response to L-cysteine", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3THK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5GFD5-1", "uniprot_id": "HS3S6_MOUSE", "mass": 37415.0, "length": 342, "protein_name": "Heparan sulfate glucosamine 3-O-sulfotransferase 6", "gene_name": "Hs3st6", "organism": "Mouse", "refseq_name": "heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform 1", "refseq_ac": "NP_001012402", "gene_names_uniprotkb": "Hs3st6", "gene_names_refseq": "3-OST-6; Hs3st6", "protein_names_uniprotkb": "Heparan sulfate glucosamine 3-O-sulfotransferase 6; 2.8.2.23; 3-OST-6; Heparan sulfate 3-O-sulfotransferase 6; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6", "protein_names_refseq": "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6; heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform 1", "tax_id": 10090, "disease": "hereditary angioedema (Disease Ontology:DOID:14735)", "pathway": " (mmu:328779); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15303968;21750661", "class_list": "glycogene", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-;2.8.2.23;2.8.2.29;2.8.2.30", "go_molecular_function": "GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase activity;GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5GFD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5NCH9-1", "uniprot_id": "GRM6_MOUSE", "mass": 95193.0, "length": 871, "protein_name": "Metabotropic glutamate receptor 6", "gene_name": "Grm6", "organism": "Mouse", "refseq_name": "metabotropic glutamate receptor 6 precursor", "refseq_ac": "NP_775548", "gene_names_uniprotkb": "Grm6; Gprc1f; Mglur6", "gene_names_refseq": "Gm3; Gprc1f; Grm6; mGluR6; nerg1; nob2; nob3; nob4", "protein_names_uniprotkb": "Metabotropic glutamate receptor 6; mGluR6", "protein_names_refseq": "G protein-coupled receptor GRM6; G protein-coupled receptor, family C, group 1, member F; metabotropic glutamate receptor 6 precursor; metabotropic glutamate receptor 6", "tax_id": 10090, "disease": "congenital stationary night blindness 1B (Disease Ontology:DOID:0110865)", "pathway": " (mmu:108072); (R-MMU-418594); (R-MMU-420499)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;18001285;18952919;21832182;22131384;24114537;29590622;38070624;38428819;7889569;9144650", "class_list": "", "function": "Complex N-glycosylation of mGluR6 is required for trans-synaptic interaction with ELFN adhesion proteins. Erratum:[J Biol Chem. 2024 Oct;300(10):107782. doi: 10.1016/j.jbc.2024.107782. PMID: 39332159], [RefSeq, PubMed]; G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision., [UniProtKB, PubMed, PubMed]; Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9409, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0042803 protein homodimerization activity;GO:0001642 group III metabotropic glutamate receptor activity;GO:0008066 glutamate receptor activity", "go_cellular_component": "GO:0035841 new growing cell tip;GO:0051286 cell tip;GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007626 locomotory behavior;GO:0007268 chemical synaptic transmission;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5NCH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U5V2-1", "uniprot_id": "HYKK_MOUSE", "mass": 42357.0, "length": 376, "protein_name": "Hydroxylysine kinase", "gene_name": "Hykk", "organism": "Mouse", "refseq_name": "hydroxylysine kinase", "refseq_ac": "NP_796325", "gene_names_uniprotkb": "Hykk; Agphd1", "gene_names_refseq": "Agphd1; C630028N24Rik; Hykk", "protein_names_uniprotkb": "Hydroxylysine kinase; 2.7.1.81; 5-hydroxy-L-lysine kinase; Aminoglycoside phosphotransferase domain-containing protein 1", "protein_names_refseq": "5-hydroxy-L-lysine kinase; aminoglycoside phosphotransferase domain containing 1; aminoglycoside phosphotransferase domain-containing protein 1; hydroxylysine kinase", "tax_id": 10090, "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:235386); (R-MMU-71064)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQ48;Q3TRW8;Q3UU28;Q8C3L8", "ec_number_list": "2.7.1.81", "go_molecular_function": "GO:0047992 hydroxylysine kinase activity;GO:0019202 amino acid kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U5V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64221-1", "uniprot_id": "HEN2_MOUSE", "mass": 15004.0, "length": 135, "protein_name": "Helix-loop-helix protein 2", "gene_name": "Nhlh2", "organism": "Mouse", "refseq_name": "helix-loop-helix protein 2", "refseq_ac": "NP_848892", "gene_names_uniprotkb": "Nhlh2; Hen2", "gene_names_refseq": "6230401I09Rik; Hen2; NSCL2; Nhlh2; Nscl-2; bHLHa34", "protein_names_uniprotkb": "Helix-loop-helix protein 2; HEN-2; NSCL-2; Nescient helix loop helix 2", "protein_names_refseq": "HEN-2; helix-loop-helix protein 2", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism (Disease Ontology:DOID:0090070)", "pathway": " (mmu:18072)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12419415;15465527;15470499;1633105;17573818;17717072;18356286;19436734;20808804;21664420;23785158;9011755;9090387", "class_list": "", "function": "Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3' (PubMed:15470499, PubMed:18356286). Involved in regulating energy expenditure, body mass, voluntary physical activity, mating behavior and reproductive longevity, acting through the hypothalamic-pituitary-gonadal axis (PubMed:12419415, PubMed:15465527, PubMed:15470499, PubMed:17717072, PubMed:23785158, PubMed:9090387). Acts as a transcriptional activator of target genes, including Ndn, Pcsk1, Mc4r (PubMed:15470499, PubMed:18356286, PubMed:21664420). Is also a transcriptional activator of KISS1 (By similarity). May act centrally to regulate function of both white and brown adipose tissue (PubMed:19436734, PubMed:20808804). Together with NHLH1, required to maintain migration and survival of cells in the anterior extramural migration stream (aes), which forms the precerebellar nuclei (PubMed:17573818). Also, in concert with Nhlh1, may determine fate of gonadotropin releasing hormone-1 (GnRH-1) neurons (PubMed:15470499)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFV7", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0060179 male mating behavior;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q64221-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GSS7-1", "uniprot_id": "H2A2A_MOUSE", "mass": 14095.0, "length": 130, "protein_name": "Histone H2A type 2-A", "gene_name": "Hist2h2aa1; Hist2h2aa2", "organism": "Mouse", "refseq_name": "histone H2A type 2-A", "refseq_ac": "NP_038577", "gene_names_uniprotkb": "Hist2h2aa1; Hist2h2aa2", "gene_names_refseq": "H2a-614; H2a-615; H2ac18; Hist2h2aa1; Hist2", "protein_names_uniprotkb": "Histone H2A type 2-A; H2a-614; H2a-615; Histone H2A.2", "protein_names_refseq": "histone H2A type 2-A; histone cluster 2, H2aa1; histone gene complex 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:15267); (mmu:319192); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 19, "publication_count": 13, "publication_id_list": "12408966;15509584;15525528;16699504;21925322;24352239;24681537;2587235;27105115;30154464;36288343;7217105;8858345", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20670;Q811M3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q6GSS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P8W9-1", "uniprot_id": "HMGB4_MOUSE", "mass": 21604.0, "length": 181, "protein_name": "High mobility group protein B4", "gene_name": "Hmgb4", "organism": "Mouse", "refseq_name": "high mobility group protein B4", "refseq_ac": "NP_081312", "gene_names_uniprotkb": "Hmgb4", "gene_names_refseq": "1700001F22Rik; Hmgb4", "protein_names_uniprotkb": "High mobility group protein B4", "protein_names_refseq": "high mobility group protein B4", "tax_id": 10090, "disease": "", "pathway": " (mmu:69317)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25609838;27608812", "class_list": "", "function": "In conclusion, the data suggest that HMGB4 is a factor that regulates chromatin and expression of neuronal differentiation markers. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAR4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P8W9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6VYH9-1", "uniprot_id": "HSH2D_MOUSE", "mass": 37233.0, "length": 334, "protein_name": "Hematopoietic SH2 domain-containing protein", "gene_name": "Hsh2d", "organism": "Mouse", "refseq_name": "hematopoietic SH2 domain-containing protein", "refseq_ac": "NP_922935", "gene_names_uniprotkb": "Hsh2d; Alx", "gene_names_refseq": "ALX; Hsh2d; Hsh2", "protein_names_uniprotkb": "Hematopoietic SH2 domain-containing protein; Adaptor in lymphocytes of unknown function X; Hematopoietic SH2 protein", "protein_names_refseq": "adaptor in lymphocytes of unknown function X; adaptor protein ALx2; hematopoietic SH2 domain-containing protein; hematopoietic SH2 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:209488)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12960172;15569688;16547253;16880512;17641043;21873522", "class_list": "", "function": "ALX is an adaptor involved in T cell activation and interleukin-2 (IL-2) promoter activation, [RefSeq, PubMed]; Adapter protein involved in tyrosine kinase and CD28 signaling (By similarity). May be a modulator of the apoptotic response through its ability to affect mitochondrial stability., [UniProtKB, PubMed]; Although adaptor in lymphocytes of unknown function X (ALX) is coexpressed with related adaptor Rlk/Itk-binding protein (RIBP) on both T- and B-lymphocytes throughout cell development, no redundancy or synergy is found., [RefSeq, PubMed]; Endogenous HSH2 expression correlates directly with survival of WEHI-231 cells, which supports the hypothesis that HSH2 modulates the apoptotic response through its ability to directly or indirectly promote mitochondrial stability, [RefSeq, PubMed]; HSH2 expression is coordinately up-regulated with known antiapoptotic molecules and directly correlates with B cell survival, [RefSeq, PubMed]; These data demonstrate that changes in HSH2 expression have profound effects on the humoral immune response., [RefSeq, PubMed]; These results suggest that ALX, in association with LAX, negatively regulates T-cell activation through inhibition of p38., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52KL3", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0042110 T cell activation;GO:0002903 negative regulation of B cell apoptotic process;GO:0051902 negative regulation of mitochondrial depolarization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6VYH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76I25-1", "uniprot_id": "HIG1C_MOUSE", "mass": 10825.0, "length": 96, "protein_name": "HIG1 domain family member 1C", "gene_name": "Higd1c", "organism": "Mouse", "refseq_name": "HIG1 domain family member 1C", "refseq_ac": "NP_001002900", "gene_names_uniprotkb": "Higd1c; Gm921; Hig1-4; Ubie", "gene_names_refseq": "Gm921; HIG1-4; Higd1c; Yghl1-4", "protein_names_uniprotkb": "HIG1 domain family member 1C", "protein_names_refseq": "HIG1 domain family member 1C; YGHL1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:380975); (R-MMU-5628897); (R-MMU-611105); (R-MMU-9707564)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0001666 response to hypoxia;GO:0097250 mitochondrial respirasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q76I25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TN16-1", "uniprot_id": "HHIP_MOUSE", "mass": 78513.0, "length": 700, "protein_name": "Hedgehog-interacting protein", "gene_name": "Hhip", "organism": "Mouse", "refseq_name": "hedgehog-interacting protein isoform 1 precursor", "refseq_ac": "NP_064655", "gene_names_uniprotkb": "Hhip; Hip", "gene_names_refseq": "Hhip1; Hhip", "protein_names_uniprotkb": "Hedgehog-interacting protein; HHIP; HIP", "protein_names_refseq": "hedgehog-interacting protein isoform 1 precursor", "tax_id": 10090, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:15245); (R-MMU-5632681)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10050855;15019948;35820727", "class_list": "", "function": "Modulates hedgehog signaling in several cell types, including brain and lung through direct interaction with members of the hedgehog family. Soluble forms inhibit Shh-induced differentiation in the fibroblast cell line C3H/10T1/2., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0B0;Q9WU59", "ec_number_list": "", "go_molecular_function": "GO:0097108 hedgehog family protein binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0009887 animal organ morphogenesis;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TN16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80SS6-1", "uniprot_id": "GPBAR_MOUSE", "mass": 35650.0, "length": 329, "protein_name": "G protein-coupled bile acid receptor 1", "gene_name": "Gpbar1", "organism": "Mouse", "refseq_name": "G-protein coupled bile acid receptor 1", "refseq_ac": "NP_778150", "gene_names_uniprotkb": "Gpbar1; Tgr5", "gene_names_refseq": "BG37; GPCR; GPR131; Gpbar1; M-BAR; TGR5", "protein_names_uniprotkb": "G protein-coupled bile acid receptor 1; M-BAR; Membrane-type receptor for bile acids", "protein_names_refseq": "G protein-coupled receptor TGR5; G-protein coupled bile acid receptor 1; membrane bile acid receptor; membrane-type receptor for bile acids", "tax_id": 10090, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:227289); (R-MMU-373076); (R-MMU-418555)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12419312;12524422;15721318;16400329;38968449", "class_list": "", "function": "Bile acids induce GLP-1 secretion through TGR5 and intracellular cAMP production in STC-1 cells, [RefSeq, PubMed]; G protein-coupled receptor for bile acid (PubMed:15721318, PubMed:16400329). Bile acid-binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:16400329). GPBAR1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:16400329). Activated by bile acids, such as lithocholate, deoxycholate, chenodeoxycholate and cholate, in descending order (By similarity). Apart from their role in lipid dietary absorption and cholesterol catabolism, bile acids act as an important signaling molecule, involved in processes, such as energy expenditure or tissue inflammation (By similarity). GPBAR1-mediated signaling promotes energy expenditure and adiposity reduction in brown adipose tissue by activating adenylate cyclase, leading to DIO2 activation (PubMed:16400329). Involved in bile acid promoted GLP-1 secretion (PubMed:15721318)., [UniProtKB, PubMed, UniProtKB, PubMed]; TGR5 is implicated in the suppression of macrophage functions by bile acids, [RefSeq, PubMed]; The bile acid receptor TGR5 inhibits platelet activation and thrombus formation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038182 G protein-coupled bile acid receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0097009 energy homeostasis;GO:1904056 positive regulation of cholangiocyte proliferation;GO:2000810 regulation of bicellular tight junction assembly;GO:0038184 adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80SS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q812B2-1", "uniprot_id": "GPHB5_MOUSE", "mass": 14249.0, "length": 130, "protein_name": "Glycoprotein hormone beta-5", "gene_name": "Gphb5", "organism": "Mouse", "refseq_name": "glycoprotein hormone beta-5 precursor", "refseq_ac": "NP_783575", "gene_names_uniprotkb": "Gphb5; Gpb5; Zlut1", "gene_names_refseq": "Gphb5; OGH; Zlut1", "protein_names_uniprotkb": "Glycoprotein hormone beta-5; Thyrostimulin subunit beta", "protein_names_refseq": "glycoprotein hormone beta subunit; glycoprotein hormone beta-5 precursor; thyrostimulin subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:217674); (R-MMU-375281); (R-MMU-418555)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15699348;16210345;21314737;25117405;26018249;40885482", "class_list": "", "function": "Expressed in newborn skulls and long bones but declined rapidly thereafter Erratum:[Endocrinology. 2018 Apr 1;159(4):1762. doi: 10.1210/en.2018-00190. PMID: 29529189], [RefSeq, PubMed]; Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism., [UniProtKB, UniProtKB]; Lacking GPB5 during acute illness does not affect the LPS-induced decrease of serum thyroid hormones Erratum:[Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E856. Duncan Bassett, J H [corrected to Bassett, J H Duncan]], [RefSeq, PubMed]; Results demonstrate in vivo regulation of central GPB5 transcription during acute illness., [RefSeq, PubMed]; When GPB5-TG mice are challenged with a high-fat diet, they gain significantly less weight and body fat than their WT littermates, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJV2", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005179 hormone activity;GO:0031531 thyrotropin-releasing hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002155 regulation of thyroid hormone receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q812B2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG55-1", "uniprot_id": "GP171_MOUSE", "mass": 36720.0, "length": 319, "protein_name": "G protein-coupled receptor 171", "gene_name": "Gpr171", "organism": "Mouse", "refseq_name": "G-protein coupled receptor 171", "refseq_ac": "NP_775574", "gene_names_uniprotkb": "Gpr171", "gene_names_refseq": "A630006E05; F730001G15Rik; Gpr171; H963", "protein_names_uniprotkb": "G protein-coupled receptor 171", "protein_names_refseq": "G-protein coupled receptor 171; probable G-protein coupled receptor 171", "tax_id": 10090, "disease": "", "pathway": " (mmu:229323)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "23022127;24043826;26495903;27117253;28425495;31308196;34428180;34615877;35942845;36933620", "class_list": "", "function": "A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice., [RefSeq, PubMed]; Findings indicate that the orphan receptor Gpr171 negatively regulates myeloid differentiation, [RefSeq, PubMed]; G protein-coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N) (PubMed:24043826, PubMed:28425495). Acts through a G(i)-alpha-mediated pathway in response to Big LEN (PubMed:24043826). Big LEN-GPR171 system plays an important role in regulating feeding and metabolism (PubMed:24043826). Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala (PubMed:28425495). Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (PubMed:31308196). Acts as a negative regulator T cell function (PubMed:34615877)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; GPR171 activation regulates morphine tolerance but not withdrawal in a test-dependent manner in mice., [RefSeq, PubMed]; GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding., [RefSeq, PubMed]; The GPR171 pathway suppresses T cell activation and limits antitumor immunity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTN1;Q8BY85;Q8CIF3", "ec_number_list": "", "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity;GO:0045028 G protein-coupled purinergic nucleotide receptor activity;GO:0008188 neuropeptide receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0051930 regulation of sensory perception of pain;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0060259 regulation of feeding behavior;GO:0045638 negative regulation of myeloid cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BG55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKT2-1", "uniprot_id": "HES7_MOUSE", "mass": 24890.0, "length": 225, "protein_name": "Transcription factor HES-7", "gene_name": "Hes7", "organism": "Mouse", "refseq_name": "transcription factor HES-7 isoform 1", "refseq_ac": "NP_149030", "gene_names_uniprotkb": "Hes7", "gene_names_refseq": "Hes7; bHLHb37", "protein_names_uniprotkb": "Transcription factor HES-7; Hairy and enhancer of split 7; bHLH factor Hes7; mHes7", "protein_names_refseq": "bHLH factor Hes7; hairy and enhancer of split 7; transcription factor HES-7 isoform 1; transcription factor HES-7", "tax_id": 10090, "disease": "spondylocostal dysostosis (Disease Ontology:DOID:0050568); spondylocostal dysostosis 4 (Disease Ontology:DOID:0112364)", "pathway": " (mmu:84653)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11260262;12783854;15170214;18775957;20087400;29187734", "class_list": "", "function": "Periodic repression by Hes7 protein is critical for the cyclic transcription of Hes7 and Lfng, and this negative feedback represents a molecular basis for the segmentation clock, [RefSeq, PubMed]; Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KPD3;Q99JA6", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0045892 negative regulation of DNA-templated transcription;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BKT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMP4-1", "uniprot_id": "GPER1_MOUSE", "mass": 42479.0, "length": 375, "protein_name": "G protein-coupled estrogen receptor 1", "gene_name": "Gper1", "organism": "Mouse", "refseq_name": "G-protein coupled estrogen receptor 1", "refseq_ac": "NP_084047", "gene_names_uniprotkb": "Gper1; Cmkrl2; Gper; Gpr30", "gene_names_refseq": "6330420K13Rik; CMKRL2; Ceprl; FEG-1; GPCR-Br; Gper1; Gper; Gpr30", "protein_names_uniprotkb": "G protein-coupled estrogen receptor 1; Chemoattractant receptor-like 2; G protein-coupled receptor 30; Membrane estrogen receptor; mER", "protein_names_refseq": "G-protein coupled estrogen receptor 1; G-protein coupled receptor 30; chemoattractant receptor-like 2; constitutively expressed peptide-like receptor like; mER; membrane estrogen receptor", "tax_id": 10090, "disease": "generalized anxiety disorder (Disease Ontology:DOID:14320); melanoma (Disease Ontology:DOID:1909)", "pathway": " (mmu:76854); (R-MMU-375276); (R-MMU-418594); (R-MMU-9634597)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "15511221;17379646;18063692;18799753;18845638;19179659;19420011;19430488;20034504;20734455;21149639;21273787;21673097;22306576;22492045;23300088;23545157;23674134;23871778;39197539", "class_list": "", "function": "G protein-coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Also functions as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; G protein-coupled receptor 30 down-regulates cofactor expression and interferes with the transcriptional activity of glucocorticoid, [RefSeq, PubMed]; GPER expression prevents estrogen-induced urinary retention in obese mice., [RefSeq, PubMed]; GPR30 is indispensable for thymocyte apoptosis that preferentially occurs in T-cell receptor beta chain double-positive thymocytes., [RefSeq, PubMed]; Results suggest that GPR30 functions as a plasma membrane receptor., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RRW0;Q9D392", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005496 steroid binding;GO:1990239 steroid hormone binding;GO:0030284 nuclear estrogen receptor activity;GO:1903924 estradiol binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0002695 negative regulation of leukocyte activation;GO:0010948 negative regulation of cell cycle process;GO:0030264 nuclear fragmentation involved in apoptotic nuclear change;GO:0032962 positive regulation of inositol trisphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8BMP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BPS4-1", "uniprot_id": "GP180_MOUSE", "mass": 48975.0, "length": 441, "protein_name": "Integral membrane protein GPR180", "gene_name": "Gpr180", "organism": "Mouse", "refseq_name": "integral membrane protein GPR180 precursor", "refseq_ac": "NP_067409", "gene_names_uniprotkb": "Gpr180; MNCb-3029", "gene_names_refseq": "E130016I23Rik; Gpr180; Itr", "protein_names_uniprotkb": "Integral membrane protein GPR180", "protein_names_refseq": "integral membrane protein GPR180 precursor; integral membrane protein GPR180; intimal thickness-related receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:58245)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;20173027;20484733;21952136;22872234;25428506;30084848;34203471;34428180;34880217;35820727;37111058;37828378", "class_list": "", "function": "GPR180 is a component of TGFbeta signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1. Publication Status: Online-Only, [RefSeq, PubMed]; Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJG1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0006468 protein phosphorylation;GO:0006629 lipid metabolic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0032094 response to food", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BPS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C3I8-1", "uniprot_id": "HGH1_MOUSE", "mass": 42916.0, "length": 393, "protein_name": "Co-chaperone protein HGH1 homolog", "gene_name": "Hgh1", "organism": "Mouse", "refseq_name": "co-chaperone protein HGH1 homolog isoform 1", "refseq_ac": "NP_067530", "gene_names_uniprotkb": "Hgh1; Brp16; Fam203a; MNCb-5873", "gene_names_refseq": "Brp16; D15Ertd741e; Fam203a; Hgh1; MNCb-5873", "protein_names_uniprotkb": "Co-chaperone protein HGH1 homolog", "protein_names_refseq": "brain protein 16; co-chaperone protein HGH1 homolog isoform 1; co-chaperone protein HGH1 homolog; family with sequence similarity 203, member A; protein FAM203A; protein HGH1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:59053)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31219806;34428180", "class_list": "", "function": "Co-chaperone involved in the folding of nascent eukaryotic elongation factor eEF2, an essential component of the translation machinery. Recognizes a non-native conformation in the central domain of eEF2 and recruits the chaperonin-containing T-complex (TRiC) to the C-terminal region of the nascent polypeptide, preventing unproductive interactions and promoting efficient folding of the N-terminal GTPase domain. May also assist in eEF2 maturation by recruiting the molecular chaperone Hsp90., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJF4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C3I8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGP5-1", "uniprot_id": "H2A1F_MOUSE", "mass": 14162.0, "length": 130, "protein_name": "Histone H2A type 1-F", "gene_name": "Hist1h2af", "organism": "Mouse", "refseq_name": "histone H2A type 1-F", "refseq_ac": "NP_783592", "gene_names_uniprotkb": "Hist1h2af", "gene_names_refseq": "H2a-221; H2ac10; Hist1h2af", "protein_names_uniprotkb": "Histone H2A type 1-F", "protein_names_refseq": "histone 1, H2af; histone H2A type 1-F; histone H2a (aa 92-128); histone cluster 1, H2af", "tax_id": 10090, "disease": "", "pathway": " (mmu:319173); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 18, "publication_count": 14, "publication_id_list": "12408966;15509584;15525528;16699504;20173027;21925322;24352239;24681537;27105115;30154464;33300544;33725478;35984892;36288343", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08AU5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CGP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGP6-1", "uniprot_id": "H2A1H_MOUSE", "mass": 13950.0, "length": 128, "protein_name": "Histone H2A type 1-H", "gene_name": "H2ac12", "organism": "Mouse", "refseq_name": "histone H2A type 1-H", "refseq_ac": "NP_783590", "gene_names_uniprotkb": "H2ac12; Hist1h2ah", "gene_names_refseq": "H2ac12; Hist1h2ah", "protein_names_uniprotkb": "Histone H2A type 1-H; H2A-clustered histone 12", "protein_names_refseq": "histone 1, H2ah; histone H2A type 1-H; histone cluster 1, H2ah", "tax_id": 10090, "disease": "", "pathway": " (mmu:319168); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214858); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-5689901); (R-MMU-606279); (R-MMU-8936459); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 18, "publication_count": 12, "publication_id_list": "12408966;15509584;15525528;16699504;21925322;24352239;24681537;27105115;30154464;33300544;34203471;36288343", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CGP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC88-1", "uniprot_id": "GRAN_MOUSE", "mass": 24663.0, "length": 220, "protein_name": "Grancalcin", "gene_name": "Gca", "organism": "Mouse", "refseq_name": "grancalcin", "refseq_ac": "NP_663498", "gene_names_uniprotkb": "Gca", "gene_names_refseq": "5133401E04Rik; Gca", "protein_names_uniprotkb": "Grancalcin", "protein_names_refseq": "grancalcin", "tax_id": 10090, "disease": "", "pathway": " (mmu:227960); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12529388;15118320;16934789;38167327", "class_list": "", "function": "Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions., [UniProtKB, PubMed]; Findings suggest that grancalcin plays a key role in leukocyte-specific functions that are responsible for host defense, [RefSeq, PubMed]; Homozygous Gca mutants appeared healthy and reproduced normally. Leukocyte recruitment into the peritoneal cavity upon induction of inflammation was not significantly affected by the absence of grancalcin., [RefSeq, PubMed]; Myeloid-derived grancalcin instigates obesity-induced insulin resistance and metabolic inflammation in male mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BL53;Q8K3Z6", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VC88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91W97-1", "uniprot_id": "HKDC1_MOUSE", "mass": 102259.0, "length": 915, "protein_name": "Hexokinase HKDC1", "gene_name": "Hkdc1", "organism": "Mouse", "refseq_name": "hexokinase HKDC1", "refseq_ac": "NP_663394", "gene_names_uniprotkb": "Hkdc1", "gene_names_refseq": "Hkdc1", "protein_names_uniprotkb": "Hexokinase HKDC1; 2.7.1.1; Hexokinase domain-containing protein 1", "protein_names_refseq": "hexokinase HKDC1; hexokinase domain-containing protein 1; putative hexokinase HKDC1", "tax_id": 10090, "disease": "retinitis pigmentosa 92 (Disease Ontology:DOID:0061107); glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (mmu:216019); (R-MMU-70171)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "25428506;25648650;27459389;30084848;30085091;30543855;37198225;37545422;38351096", "class_list": "", "function": "Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases (By similarity). Has low glucose phosphorylating activity compared to other hexokinases (By similarity). Involved in glucose homeostasis and hepatic lipid accumulation (PubMed:30543855). Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (PubMed:25648650, PubMed:27459389)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity. Publication Status: Online-Only, [RefSeq, PubMed]; Proteomics identifies the developmental regulation of HKDC1 in liver of pigs and mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKJ9", "ec_number_list": "2.7.1.1;2.7.1.-", "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0005524 ATP binding;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031966 mitochondrial membrane;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91W97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZY2-1", "uniprot_id": "HRH4_MOUSE", "mass": 44249.0, "length": 391, "protein_name": "Histamine H4 receptor", "gene_name": "Hrh4", "organism": "Mouse", "refseq_name": "histamine H4 receptor", "refseq_ac": "NP_694727", "gene_names_uniprotkb": "Hrh4", "gene_names_refseq": "AXOR35; BG26; GPCR105; GPRv53; H4R; H4; HH4R; Hrh4", "protein_names_uniprotkb": "Histamine H4 receptor; H4R; HH4R", "protein_names_refseq": "histamine H4 receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:225192); (R-MMU-390650); (R-MMU-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12626656;15265943;33216475;34680083;34680152", "class_list": "", "function": "G protein-coupled receptor primarily expressed in immune cells such as mast cells, eosinophils, basophils, dendritic cells and neutrophils that plays a key role in immune and inflammatory responses. Mediates chemotaxis of immune cells to sites of inflammation or injury by responding to histamine. Activation by histamine also influences the release of proinflammatory cytokines such as TNF, CCL4, IL6 and IFN-gamma. Ligand binding induces a conformation change that triggers signaling via G(i)/GNAI1 leading to decreased intracellular cAMP levels by inhibiting adenylate cyclase activity (By similarity). In addition, plays a role in the control of renal reabsorption processes, particularly albumin uptake (PubMed:34680152)., [UniProtKB, UniProtKB, PubMed]; Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells., [RefSeq, PubMed]; Mouse eosinophils express H4. CCL16 induced pertussis toxin-sensitive calcium mobilization and chemotaxis only in murine L1.2 cells expressing H4., [RefSeq, PubMed]; The Histamine H4 Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A3 Receptor Agonist IB-MECA: Role of CD4(+) T Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The Interplay between Histamine H4 Receptor and the Kidney Function: The Lesson from H4 Receptor Knockout Mice. Publication Status: Online-Only, [RefSeq, PubMed]; The Novel H4R Antagonist 1-[(5-Chloro-2, 3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007) Attenuates Several Symptoms in Murine Allergic Asthma., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030594 neurotransmitter receptor activity;GO:0004969 histamine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0006954 inflammatory response;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91ZY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99M31-1", "uniprot_id": "HSP7E_MOUSE", "mass": 54650.0, "length": 509, "protein_name": "Heat shock 70 kDa protein 14", "gene_name": "Hspa14", "organism": "Mouse", "refseq_name": "heat shock 70 kDa protein 14 isoform 1", "refseq_ac": "NP_056580", "gene_names_uniprotkb": "Hspa14; Hsp70-4", "gene_names_refseq": "70kDa; HSP70L1; Hsp70-4; Hspa14; NST-1; hsr.1", "protein_names_uniprotkb": "Heat shock 70 kDa protein 14; NST-1; hsr.1", "protein_names_refseq": "heat shock 70 kDa protein 14 isoform 1; heat shock 70 kDa protein 14; heat shock 70kDa protein 14; heat shock protein 14; heat shock protein 4; heat shock protein, 70 kDa 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:50497); (R-MMU-3371453)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21730052;31219806;34428180;34887587;39627609", "class_list": "", "function": "Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity)., [UniProtKB]; TLR4 is a key receptor mediating the interaction of Hsp70L1 with DCs and subsequently enhancing the induction of Th1 immune response by Hsp70L1/antigen fusion protein, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJH7;Q3U5W7;Q60637", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005840 ribosome", "go_biological_process": "GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99M31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2U9-1", "uniprot_id": "H2B3A_MOUSE", "mass": 13994.0, "length": 126, "protein_name": "H2B.U histone 2", "gene_name": "H2bu2", "organism": "Mouse", "refseq_name": "H2B.U histone 2", "refseq_ac": "NP_084358", "gene_names_uniprotkb": "H2bu2; Hist3h2ba", "gene_names_refseq": "1500011O09Rik; H2bc27; H2bu2; Hist3h2ba", "protein_names_uniprotkb": "H2B.U histone 2; Histone H2B type 3-A", "protein_names_refseq": "H2B.U histone 2; histone 3, H2ba; histone H2B type 3-A; histone cluster 3, H2ba", "tax_id": 10090, "disease": "", "pathway": " (mmu:78303); (R-MMU-110330); (R-MMU-110331); (R-MMU-212300); (R-MMU-2299718); (R-MMU-2559586); (R-MMU-3214847); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-606279); (R-MMU-69473); (R-MMU-8936459); (R-MMU-9018519); (R-MMU-9670095); (R-MMU-9764725); (R-MMU-9841922); (R-MMU-9843940); (R-MMU-9909649); (R-MMU-9940951)", "pathway_count": 20, "publication_count": 15, "publication_id_list": "12408966;15197225;16039583;16107708;20647423;21925322;22389435;24681537;25605945;27105115;30154464;31645732;32822587;34428180;35984892", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9D2U9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3B1-1", "uniprot_id": "HACD2_MOUSE", "mass": 28402.0, "length": 254, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2", "gene_name": "Hacd2", "organism": "Mouse", "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2", "refseq_ac": "NP_076076", "gene_names_uniprotkb": "Hacd2; Ptplb", "gene_names_refseq": "6330408J20Rik; Hacd2; Hcad2; Ptplb", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2; 3-hydroxyacyl-CoA dehydratase 2; 4.2.1.134; HACD2; Protein-tyrosine phosphatase-like member B", "protein_names_refseq": "protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; protein-tyrosine phosphatase-like member B; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:70757); (R-MMU-75876)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10644438;30084848;34428180;36693621;37453647", "class_list": "", "function": "Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, UniProtKB]; Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UG38;Q9JLK1", "ec_number_list": "4.2.1.134;1.1.1.n12;4.2.1.107;4.2.1.119", "go_molecular_function": "GO:0019899 enzyme binding;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D3B1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7B7-1", "uniprot_id": "GPX8_MOUSE", "mass": 24148.0, "length": 209, "protein_name": "Protein peroxidase GPX8", "gene_name": "Gpx8", "organism": "Mouse", "refseq_name": "probable glutathione peroxidase 8 isoform 1", "refseq_ac": "NP_081403", "gene_names_uniprotkb": "Gpx8", "gene_names_refseq": "2310016C16Rik; GPx-8; GSHPx-8; Gpx8", "protein_names_uniprotkb": "Protein peroxidase GPX8; 5.3.4.1; GPx-8; GSHPx-8", "protein_names_refseq": "probable glutathione peroxidase 8 isoform 1; probable glutathione peroxidase 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:69590); (R-MMU-3299685)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;31219806;31782617;37828378", "class_list": "", "function": "Acts as an endoplasmic reticulum (ER) thiol peroxidase that maintains ER redox homeostasis and protects the cytosol from ER-derived H(2)O(2). Functions in a redox relay with ERO1A, using ERO1A-generated H(2)O(2) to drive PDI oxidation, linking peroxide detoxification to productive disulfide formation. Modulates endoplasmic reticulum Ca(2+) levels mainly through SERCA pump activity and partially by influencing passive Ca(2+) leakage., [UniProtKB, UniProtKB]; Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VE68", "ec_number_list": "5.3.4.1;1.8.3.2", "go_molecular_function": "GO:0004601 peroxidase activity;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane", "go_biological_process": "GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D7B7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLZ6-1", "uniprot_id": "HIC2_MOUSE", "mass": 66766.0, "length": 619, "protein_name": "Hypermethylated in cancer 2 protein", "gene_name": "Hic2", "organism": "Mouse", "refseq_name": "hypermethylated in cancer 2 protein", "refseq_ac": "NP_849253", "gene_names_uniprotkb": "Hic2; Kiaa1020", "gene_names_refseq": "HRG22; Hic2; mKIAA1020", "protein_names_uniprotkb": "Hypermethylated in cancer 2 protein; Hic-2", "protein_names_refseq": "hic-2; hypermethylated in cancer 2 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:58180)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "24748541;25428506;29061339;30084848;31127867", "class_list": "", "function": "Data suggest that HIC2 haploinsufficiency likely contributes to the cardiac defects seen in distal 22q11 deletion syndrome, [RefSeq, PubMed]; HIC2 is a pivotal transcriptional activator of SIRT1, [RefSeq, PubMed]; HIC2 regulates a switching event within both the contractile machinery of cardiomyocytes and the oxygen carrying systems during the developmental period. Erratum:[J Mol Cell Cardiol. 2023 Oct;183:102. doi: 10.1016/j.yjmcc.2023.07.010. PMID: 37517876], [RefSeq, PubMed]; Transcriptional repressor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U030;Q3ULP4;Q5K036;Q8BSZ9;Q8C3T5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JLZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYK4-1", "uniprot_id": "H6ST3_MOUSE", "mass": 55037.0, "length": 470, "protein_name": "Heparan-sulfate 6-O-sulfotransferase 3", "gene_name": "Hs6st3", "organism": "Mouse", "refseq_name": "heparan-sulfate 6-O-sulfotransferase 3", "refseq_ac": "NP_056635", "gene_names_uniprotkb": "Hs6st3", "gene_names_refseq": "6OST3; HS6ST-3; Hs6st3", "protein_names_uniprotkb": "Heparan-sulfate 6-O-sulfotransferase 3; 2.8.2.-; HS6ST-3; mHS6ST-3", "protein_names_refseq": "heparan-sulfate 6-O-sulfotransferase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:50787); (R-MMU-2022928)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;10644753;15499561", "class_list": "glycogene", "function": "6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate., [UniProtKB]; 6OST3 appears at later stages and in a more restricted manner than its isoenzymes during development, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q148Q1", "ec_number_list": "2.8.2.-", "go_molecular_function": "GO:0017095 heparan sulfate 6-sulfotransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QYK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21183-1", "uniprot_id": "IL5RA_MOUSE", "mass": 46989.0, "length": 415, "protein_name": "Interleukin-5 receptor subunit alpha", "gene_name": "Il5ra", "organism": "Mouse", "refseq_name": "interleukin-5 receptor subunit alpha precursor", "refseq_ac": "NP_032396", "gene_names_uniprotkb": "Il5ra; Il5r", "gene_names_refseq": "CD125; CDw125; Il5ra; Il5r", "protein_names_uniprotkb": "Interleukin-5 receptor subunit alpha; IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA", "protein_names_refseq": "IL-5 receptor alpha chain; IL-5 receptor subunit alpha; IL-5R subunit alpha; interleukin-5 receptor subunit alpha precursor; interleukin-5 receptor subunit alpha", "tax_id": 10090, "disease": "respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); mastocytosis (Disease Ontology:DOID:350)", "pathway": " (mmu:16192); (R-MMU-512988); (R-MMU-5673001); (R-MMU-912526)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "1873482;21750661;2265612;26495903;31415658;33857341", "class_list": "", "function": "Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:1873482). Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway., [UniProtKB, PubMed, UniProtKB]; Expression of IL-5 receptor alpha by murine and human lung neutrophils. Publication Status: Online-Only, [RefSeq, PubMed]; More than neutrophils: Lin(+)Ly6G(+)IL-5Ralpha(+) multipotent myeloid cells (MMCs) are dominant in normal murine bone marrow and retain capacity to differentiate into eosinophils and monocytes., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004914 interleukin-5 receptor activity;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032674 regulation of interleukin-5 production;GO:0030222 eosinophil differentiation;GO:0038043 interleukin-5-mediated signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0002437 inflammatory response to antigenic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P21183-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48346-1", "uniprot_id": "IL15_MOUSE", "mass": 18593.0, "length": 162, "protein_name": "Interleukin-15", "gene_name": "Il15", "organism": "Mouse", "refseq_name": "interleukin-15 preproprotein", "refseq_ac": "NP_001241676", "gene_names_uniprotkb": "Il15", "gene_names_refseq": "IL-15; Il15", "protein_names_uniprotkb": "Interleukin-15; IL-15", "protein_names_refseq": "interleukin-15 preproprotein", "tax_id": 10090, "disease": "pleurisy (Disease Ontology:DOID:10247); respiratory failure (Disease Ontology:DOID:11162); adult respiratory distress syndrome (Disease Ontology:DOID:11394); listeriosis (Disease Ontology:DOID:11573); pulmonary sarcoidosis (Disease Ontology:DOID:13406); aspergillosis (Disease Ontology:DOID:13564); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); periodontal disease (Disease Ontology:DOID:3388); coronary artery disease (Disease Ontology:DOID:3393); brain infarction (Disease Ontology:DOID:3454); pulmonary fibrosis (Disease Ontology:DOID:3770); pancreatitis (Disease Ontology:DOID:4989); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); lung disease (Disease Ontology:DOID:850); viral infectious disease (Disease Ontology:DOID:934); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16168); (R-MMU-8983432)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10882748;11466332;17947230;19632221;21750661;34428180;7759105;8757333", "class_list": "", "function": "Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:11466332, PubMed:8757333). Stimulates the proliferation and activation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines (PubMed:8757333). In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection (By similarity). Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (PubMed:10882748, PubMed:19632221)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing to generate a mature cytokine that stimulates the proliferation of natural killer cells. The transgenic mice overexpressing the encoded protein exhibit an increase in the number of memory CD8+ T cells in a naive state and enhanced protection against bacterial infections. Mice lacking the encoded protein exhibit impaired protection against a strain of attenuated Mycobacterium. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050691 regulation of defense response to virus by host;GO:0032740 positive regulation of interleukin-17 production;GO:0045062 extrathymic T cell selection;GO:1904100 positive regulation of protein O-linked glycosylation;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P48346-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SV42-1", "uniprot_id": "ILEUC_MOUSE", "mass": 41920.0, "length": 375, "protein_name": "Leukocyte elastase inhibitor C", "gene_name": "Serpinb1c", "organism": "Mouse", "refseq_name": "leukocyte elastase inhibitor C isoform 1", "refseq_ac": "NP_766639", "gene_names_uniprotkb": "Serpinb1c", "gene_names_refseq": "EIC; Serpinb1c; ovalbumin", "protein_names_uniprotkb": "Leukocyte elastase inhibitor C; Serine protease inhibitor EIC; Serpin B1c", "protein_names_refseq": "leukocyte elastase inhibitor C isoform 1; leukocyte elastase inhibitor C; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1c; serine (or cysteine) proteinase inhibitor, clade B, member 1c; serine protease inhibitor EIC; serpin B1c", "tax_id": 10090, "disease": "alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (mmu:380839)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12189154;21750661;30692621;34830471;35820727", "class_list": "", "function": "CDNA cloning, gene structure and biological characterization homologous to human MNEI, [RefSeq, PubMed]; Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G (By similarity). During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SW82;Q8K3Y1", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0030336 negative regulation of cell migration;GO:0032691 negative regulation of interleukin-1 beta production;GO:0010951 negative regulation of endopeptidase activity;GO:0044342 type B pancreatic cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5SV42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ASA8-1", "uniprot_id": "IPIL1_MOUSE", "mass": 62217.0, "length": 547, "protein_name": "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1", "gene_name": "Itpripl1", "organism": "Mouse", "refseq_name": "inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 isoform a precursor", "refseq_ac": "NP_001156999", "gene_names_uniprotkb": "Itpripl1", "gene_names_refseq": "1700041B20Rik; Itpripl1", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1", "protein_names_refseq": "inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 isoform a precursor; inositol 1,4,5-trisphosphate receptor-interacting protein-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73338)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-NFkB signaling cascade and calcium influx., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L3P2;B7ZCY2", "ec_number_list": "", "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0043410 positive regulation of MAPK cascade;GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0050860 negative regulation of T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2ASA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47877-1", "uniprot_id": "IBP2_MOUSE", "mass": 32847.0, "length": 305, "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "Igfbp2", "organism": "Mouse", "refseq_name": "insulin-like growth factor-binding protein 2 isoform 1 precursor", "refseq_ac": "NP_032368", "gene_names_uniprotkb": "Igfbp2; Igfbp-2", "gene_names_refseq": "IBP-2; Igfbp-2; Igfbp2; mIGFBP-2", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 2; IBP-2; IGF-binding protein 2; IGFBP-2; mIGFBP-2", "protein_names_refseq": "IGF-binding protein 2; insulin-like growth factor-binding protein 2 isoform 1 precursor", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypothyroidism (Disease Ontology:DOID:1459); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16008); (R-MMU-381426)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18276763;21750661;26773517;39117630;7529732;7680327", "class_list": "", "function": "Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18276763). Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation (PubMed:26773517). Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; The protein encoded by this gene is one of several similar proteins that bind insulin-like growth factors I and II (Igf-I and Igf-II). The encoded protein can be secreted into the bloodstream, where it binds Igf-I and Igf-II with high affinity, or it can remain intracellular, interacting with many different ligands. Two transcript variants, one encoding a secreted isoform and the other encoding a nonsecreted isoform, have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61722;Q91VK7", "ec_number_list": "", "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0005520 insulin-like growth factor binding;GO:0004864 protein phosphatase inhibitor activity;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007584 response to nutrient;GO:0051384 response to glucocorticoid;GO:0007565 female pregnancy;GO:0009612 response to mechanical stimulus;GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P47877-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09026-1", "uniprot_id": "HXB3_MOUSE", "mass": 44353.0, "length": 433, "protein_name": "Homeobox protein Hox-B3", "gene_name": "Hoxb3", "organism": "Mouse", "refseq_name": "homeobox protein Hox-B3", "refseq_ac": "NP_001073338", "gene_names_uniprotkb": "Hoxb3; Hox-2.7; Hoxb-3", "gene_names_refseq": "Hox-2.7; Hoxb3", "protein_names_uniprotkb": "Homeobox protein Hox-B3; Homeobox protein Hox-2.7; Homeobox protein MH-23", "protein_names_refseq": "homeo box B3; homeobox protein Hox-2.7; homeobox protein Hox-B3; homeobox protein MH-23", "tax_id": 10090, "disease": "", "pathway": " (mmu:15410)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12616489;1582411;21750661;2463210;2890503;7890121", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P10285;Q4PJ06;Q61680", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0030878 thyroid gland development;GO:0021546 rhombomere development;GO:0021615 glossopharyngeal nerve morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09026-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09027-1", "uniprot_id": "HXD3_MOUSE", "mass": 45976.0, "length": 433, "protein_name": "Homeobox protein Hox-D3", "gene_name": "Hoxd3", "organism": "Mouse", "refseq_name": "homeobox protein Hox-D3", "refseq_ac": "NP_034598", "gene_names_uniprotkb": "Hoxd3; Hox-4.1; Hoxd-3", "gene_names_refseq": "Hox-4.1; Hox-5.5; Hoxd3", "protein_names_uniprotkb": "Homeobox protein Hox-D3; Homeobox protein Hox-4.1; Homeobox protein MH-19", "protein_names_refseq": "homeo box D3; homeo box D4; homeobox protein Hox-4.1; homeobox protein Hox-D3; homeobox protein MH-19", "tax_id": 10090, "disease": "", "pathway": " (mmu:15434)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;2890503;7710686;7916214;8710855", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUD3", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0016235 aggresome", "go_biological_process": "GO:0030878 thyroid gland development;GO:0021615 glossopharyngeal nerve morphogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P09027-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89113-1", "uniprot_id": "IER5_MOUSE", "mass": 31784.0, "length": 308, "protein_name": "Immediate early response gene 5 protein", "gene_name": "Ier5", "organism": "Mouse", "refseq_name": "immediate early response gene 5 protein", "refseq_ac": "NP_034630", "gene_names_uniprotkb": "Ier5", "gene_names_refseq": "Ier5", "protein_names_uniprotkb": "Immediate early response gene 5 protein", "protein_names_refseq": "immediate early response gene 5 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:15939)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10049588;25428506", "class_list": "", "function": "Plays a role as a transcription factor. Mediates positive transcriptional regulation of several chaperone gene during the heat shock response in a HSF1-dependent manner. Mediates negative transcriptional regulation of CDC25B expression. Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A. Involved in the regulation of cell proliferation and resistance to thermal stress. Involved in the cell cycle checkpoint and survival in response to ionizing radiation. Associates with chromatin to the CDC25B promoter., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CGI0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:1900036 positive regulation of cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O89113-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01580-1", "uniprot_id": "IFNG_MOUSE", "mass": 17907.0, "length": 155, "protein_name": "Interferon gamma", "gene_name": "Ifng", "organism": "Mouse", "refseq_name": "interferon gamma precursor", "refseq_ac": "NP_032363", "gene_names_uniprotkb": "Ifng", "gene_names_refseq": "IFN-g; If2f; Ifg; Ifng", "protein_names_uniprotkb": "Interferon gamma; IFN-gamma", "protein_names_refseq": "IFN-gamma; gamma interferon; interferon 2f; interferon gamma precursor", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); renal fibrosis (Disease Ontology:DOID:0050855); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); medulloblastoma (Disease Ontology:DOID:0050902); stroke (Disease Ontology:DOID:0051061); chronic pancreatitis (Disease Ontology:DOID:0051065); lupus nephritis (Disease Ontology:DOID:0080162); tuberous sclerosis 2 (Disease Ontology:DOID:0080325); COVID-19 (Disease Ontology:DOID:0080600); polymyositis (Disease Ontology:DOID:0080745); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); immunodeficiency 69 (Disease Ontology:DOID:0112006); sensorineural hearing loss (Disease Ontology:DOID:10003); dermatomyositis (Disease Ontology:DOID:10223); celiac disease (Disease Ontology:DOID:10608); otitis media (Disease Ontology:DOID:10754); nephritis (Disease Ontology:DOID:10952); urinary bladder cancer (Disease Ontology:DOID:11054); brucellosis (Disease Ontology:DOID:11077); pulpitis (Disease Ontology:DOID:11121); allergic conjunctivitis (Disease Ontology:DOID:11204); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); suppurative otitis media (Disease Ontology:DOID:11506); panuveitis (Disease Ontology:DOID:12030); factor VIII deficiency (Disease Ontology:DOID:12134); Chagas disease (Disease Ontology:DOID:12140); primary biliary cholangitis (Disease Ontology:DOID:12236); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); malaria (Disease Ontology:DOID:12365); aplastic anemia (Disease Ontology:DOID:12449); ataxia telangiectasia (Disease Ontology:DOID:12704); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); Fanconi anemia (Disease Ontology:DOID:13636); toxic shock syndrome (Disease Ontology:DOID:14115); selective IgG deficiency disease (Disease Ontology:DOID:14176); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); viral hepatitis (Disease Ontology:DOID:1884); hepatitis (Disease Ontology:DOID:2237); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); glucosephosphate dehydrogenase deficiency (Disease Ontology:DOID:2862); endometriosis (Disease Ontology:DOID:289); glomerulonephritis (Disease Ontology:DOID:2921); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); high grade glioma (Disease Ontology:DOID:3070); chronic granulomatous disease (Disease Ontology:DOID:3265); atopic dermatitis (Disease Ontology:DOID:3310); mixed connective tissue disease (Disease Ontology:DOID:3492); acute retinal necrosis syndrome (Disease Ontology:DOID:3611); tuberculosis (Disease Ontology:DOID:399); systemic scleroderma (Disease Ontology:DOID:418); allergic rhinitis (Disease Ontology:DOID:4481); endophthalmitis (Disease Ontology:DOID:4692); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute disseminated encephalomyelitis (Disease Ontology:DOID:639); rheumatoid arthritis (Disease Ontology:DOID:7148); autoimmune thyroiditis (Disease Ontology:DOID:7188); abdominal aortic aneurysm (Disease Ontology:DOID:7693); lung disease (Disease Ontology:DOID:850); myeloid leukemia (Disease Ontology:DOID:8692); Crohn's disease (Disease Ontology:DOID:8778); leishmaniasis (Disease Ontology:DOID:9065); systemic lupus erythematosus (Disease Ontology:DOID:9074); eczema herpeticum (Disease Ontology:DOID:9123); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); vesicoureteral reflux (Disease Ontology:DOID:9620); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15978); (R-MMU-877300); (R-MMU-877312); (R-MMU-9732724)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11585387;20535209;21952136;25078851;6310596;8456301", "class_list": "", "function": "This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]., [RefSeq]; Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:11585387, PubMed:8456301). Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (PubMed:20535209, PubMed:25078851)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 84, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q542B8", "ec_number_list": "", "go_molecular_function": "GO:0005133 type II interferon receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0043204 perikaryon;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0032834 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response;GO:0038110 interleukin-2-mediated signaling pathway;GO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P01580-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01586-1", "uniprot_id": "IL3_MOUSE", "mass": 18540.0, "length": 166, "protein_name": "Interleukin-3", "gene_name": "Il3", "organism": "Mouse", "refseq_name": "interleukin-3 precursor", "refseq_ac": "NP_034686", "gene_names_uniprotkb": "Il3; Csfmu; Il-3", "gene_names_refseq": "BPA; Csfmu; HCGF; Il-3; Il3; MCGF; PSF", "protein_names_uniprotkb": "Interleukin-3; Hematopoietic growth factor; IL-3; MCGF; Mast cell growth factor; Multipotential colony-stimulating factor; P-cell-stimulating factor", "protein_names_refseq": "P-cell-stimulating factor; hematopoietic growth factor; interleukin-3 precursor; mast cell growth factor; multipotential colony-stimulating factor", "tax_id": 10090, "disease": "Graves ophthalmopathy (Disease Ontology:DOID:0081120); Alzheimer's disease (Disease Ontology:DOID:10652); prostatic hypertrophy (Disease Ontology:DOID:11132); pyelonephritis (Disease Ontology:DOID:11400); Graves' disease (Disease Ontology:DOID:12361); major depressive disorder (Disease Ontology:DOID:1470); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); osteosarcoma (Disease Ontology:DOID:3347); Ebola virus disease (Disease Ontology:DOID:4325); rheumatoid arthritis (Disease Ontology:DOID:7148); genital herpes (Disease Ontology:DOID:8704); psoriasis (Disease Ontology:DOID:8893); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16187); (R-MMU-512988); (R-MMU-5673001); (R-MMU-912526)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10376805;1445902;21329364;31990690;3918308;3926497;3935516;6322187;6420702;8378315;9446636", "class_list": "", "function": "Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Also stimulates mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (By similarity). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (PubMed:10376805, PubMed:31990690, PubMed:8378315). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005135 interleukin-3 receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0033026 negative regulation of mast cell apoptotic process;GO:0035162 embryonic hemopoiesis;GO:0038156 interleukin-3-mediated signaling pathway;GO:0001934 positive regulation of protein phosphorylation;GO:0006110 regulation of glycolytic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P01586-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01590-1", "uniprot_id": "IL2RA_MOUSE", "mass": 30723.0, "length": 268, "protein_name": "Interleukin-2 receptor subunit alpha", "gene_name": "Il2ra", "organism": "Mouse", "refseq_name": "interleukin-2 receptor subunit alpha precursor", "refseq_ac": "NP_032393", "gene_names_uniprotkb": "Il2ra; Il2r", "gene_names_refseq": "CD25; Il2ra; Il2r; Ly-43", "protein_names_uniprotkb": "Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; p55", "protein_names_refseq": "IL-2 receptor subunit alpha; IL-2-RA; IL-2R alpha chain; IL-2R subunit alpha; IL2-RA; interleukin-2 receptor subunit alpha precursor; interleukin-2 receptor subunit alpha; p55 chain", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Korean hemorrhagic fever (Disease Ontology:DOID:0050200); inflammatory bowel disease (Disease Ontology:DOID:0050589); COVID-19 (Disease Ontology:DOID:0080600); type 1 diabetes mellitus 10 (Disease Ontology:DOID:0110749); immunodeficiency 41 (Disease Ontology:DOID:0111968); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); Sjogren's syndrome (Disease Ontology:DOID:12894); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); lymphopenia (Disease Ontology:DOID:614); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:16184); (R-MMU-5673001); (R-MMU-9020558); (R-MMU-912526)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "2987826;3135330;3921620", "class_list": "", "function": "Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, 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Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P07349-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07350-1", "uniprot_id": "IFNA6_MOUSE", "mass": 21499.0, "length": 189, "protein_name": "Interferon alpha-6", "gene_name": "Ifna6", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ifna6; Ifa6; Ifa8; Ifna8", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon alpha-6; IFN-alpha-6; IFN-alpha-8; Interferon alpha-8", "protein_names_refseq": "", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); common cold (Disease Ontology:DOID:10459); anogenital venereal wart (Disease Ontology:DOID:11168); sarcoidosis (Disease Ontology:DOID:11335); Crimean-Congo hemorrhagic fever (Disease Ontology:DOID:12287); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); melioidosis (Disease Ontology:DOID:5052); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:15969); (R-MMU-909733); (R-MMU-912694)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;2471809;2987811", "class_list": "", "function": "Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EKS5;P17660", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P07350-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09024-1", "uniprot_id": "HXB7_MOUSE", "mass": 23967.0, "length": 217, "protein_name": "Homeobox protein Hox-B7", "gene_name": "Hoxb7", "organism": "Mouse", "refseq_name": "homeobox protein Hox-B7", "refseq_ac": "NP_034590", "gene_names_uniprotkb": "Hoxb7; Hox-2.3; Hoxb-7", "gene_names_refseq": "Hox-2.3; Hoxb7", "protein_names_uniprotkb": "Homeobox protein Hox-B7; Homeobox protein Hox-2.3; Homeobox protein MH-22B; Homeobox protein MuB1", "protein_names_refseq": "homeo box B7; homeobox protein Hox-2.3; homeobox protein Hox-B7; homeobox protein MH-22B; homeobox protein MuB1", "tax_id": 10090, "disease": "invasive ductal carcinoma (Disease Ontology:DOID:3008); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:15415)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11290787;2889183;2890503;2891608;2896332;2901346;7791786", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A9Z9;Q3UW15", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P09024-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09079-1", "uniprot_id": "HXB5_MOUSE", "mass": 29464.0, "length": 269, "protein_name": "Homeobox protein Hox-B5", "gene_name": "Hoxb5", "organism": "Mouse", "refseq_name": "homeobox protein Hox-B5", "refseq_ac": "NP_032294", "gene_names_uniprotkb": "Hoxb5; Hox-2.1; Hoxb-5", "gene_names_refseq": "Hox-2.1; Hoxb5", "protein_names_uniprotkb": "Homeobox protein Hox-B5; Homeobox protein H24.1; Homeobox protein Hox-2.1; Homeobox protein Mu-1", "protein_names_refseq": "homeo box B5; homeobox protein H24.1; homeobox protein Hox-2.1; homeobox protein Hox-B5; homeobox protein Mu-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15413)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "2889591;31219806;31599954;38324932;4058581;4075393", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]; Transcription factor Hoxb5 reveals the unidirectional hierarchy of hematopoietic stem cell pool., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZAY8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09079-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09633-1", "uniprot_id": "HXC9_MOUSE", "mass": 29234.0, "length": 260, "protein_name": "Homeobox protein Hox-C9", "gene_name": "Hoxc9", "organism": "Mouse", "refseq_name": "homeobox protein Hox-C9", "refseq_ac": "NP_032298", "gene_names_uniprotkb": "Hoxc9; Hox-3.2; Hoxc-9", "gene_names_refseq": "Hox-3.2; Hoxc9", "protein_names_uniprotkb": "Homeobox protein Hox-C9; Homeobox protein Hox-3.2", "protein_names_refseq": "homeo box C9; homeobox protein Hox-3.2; homeobox protein Hox-C9", "tax_id": 10090, "disease": "", "pathway": " (mmu:15427)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1696731;1723949;2900757;38446596", "class_list": "", "function": "HOXC9 characterizes a suppressive tumor immune microenvironment and integration with multiple immune biomarkers predicts response to PD-1 blockade plus chemotherapy in lung adenocarcinoma., [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0016235 aggresome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0009954 proximal/distal pattern formation;GO:0048704 embryonic skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P09633-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DOV2-1", "uniprot_id": "IFI4_MOUSE", "mass": 69438.0, "length": 619, "protein_name": "Interferon-activable protein 204", "gene_name": "Ifi204", "organism": "Mouse", "refseq_name": "interferon-activable protein 204", "refseq_ac": "NP_032355", "gene_names_uniprotkb": "Ifi204", "gene_names_refseq": "Ifi16; Ifi204; p204", "protein_names_uniprotkb": "Interferon-activable protein 204; Ifi-204; Interferon-inducible protein p204", "protein_names_refseq": "ifi-204; interferon, gamma-inducible gene 204; interferon, gamma-inducible protein 16; interferon-activable protein 204; interferon-inducible protein p204", "tax_id": 10090, "disease": "", "pathway": " (mmu:15951); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10329630;11940648;15557274;16244109;16458891;16556595;16556596;22645316;2477366;25710914;28529930;30936875;31219806;33619523;34428180;35869806;36379277", "class_list": "", "function": "IFI204 protects host defense against Staphylococcus aureus-induced pneumonia by promoting extracellular traps formation., [RefSeq, PubMed]; Interferon-gamma inducible protein 16 and type I interferon receptors expression in experimental apical periodontitis induced in wild-type mice., [RefSeq, PubMed]; Interferon-stimulated protein that plays a role in several biological processes including cell differentiation, autophagy and innate immunity (PubMed:16244109, PubMed:25710914, PubMed:30936875). Cooperates with CGAS to sense dsDNA and activates the STING-dependent type I IFN pathway (PubMed:25710914, PubMed:33619523). Mechanistically, gets acetylated upon bacterial infection and then translocates from nucleus into cytoplasm to recruit STING for activation of TBK1-dependent IRF3 nuclear translocation and IFN-beta release (PubMed:28529930). Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNS3;P15092;Q08619;Q3TM07;Q3U776;Q3U7F4;Q3U7K5;Q3UCH9;Q8C4X3;Q921V9", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0003690 double-stranded DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045087 innate immune response;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P0DOV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10168-1", "uniprot_id": "IL7_MOUSE", "mass": 17727.0, "length": 154, "protein_name": "Interleukin-7", "gene_name": "Il7", "organism": "Mouse", "refseq_name": "interleukin-7 isoform a precursor", "refseq_ac": "NP_032397", "gene_names_uniprotkb": "Il7; Il-7", "gene_names_refseq": "A630026I06Rik; Il-7; Il7; hlb368", "protein_names_uniprotkb": "Interleukin-7; IL-7", "protein_names_refseq": "interleukin-7 isoform a precursor", "tax_id": 10090, "disease": "immunodeficiency 130 with HPV-related verrucosis (Disease Ontology:DOID:0061171); COVID-19 (Disease Ontology:DOID:0080600); Alzheimer's disease (Disease Ontology:DOID:10652); high grade glioma (Disease Ontology:DOID:3070); periodontal disease (Disease Ontology:DOID:3388); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:16196); (R-MMU-1266695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "2329282;28811625;3259677;37373104;7699333", "class_list": "", "function": "Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis (PubMed:28811625, PubMed:7699333). Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5., [UniProtKB, UniProtKB, PubMed, PubMed]; IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005139 interleukin-7 receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:0002360 T cell lineage commitment;GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0019725 cellular homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P10168-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10284-1", "uniprot_id": "HXB4_MOUSE", "mass": 27519.0, "length": 250, "protein_name": "Homeobox protein Hox-B4", "gene_name": "Hoxb4", "organism": "Mouse", "refseq_name": "homeobox protein Hox-B4", "refseq_ac": "NP_034589", "gene_names_uniprotkb": "Hoxb4; Hox-2.6; Hoxb-4", "gene_names_refseq": "Hox-2.6; Hoxb4", "protein_names_uniprotkb": "Homeobox protein Hox-B4; Homeobox protein Hox-2.6", "protein_names_refseq": "homeo box B4; homeobox protein Hox-2.6; homeobox protein Hox-B4", "tax_id": 10090, "disease": "leukemia (Disease Ontology:DOID:1240)", "pathway": " (mmu:15412)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2463210", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZB4;Q4VBG0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008283 cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060218 hematopoietic stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P10284-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10628-1", "uniprot_id": "HXD4_MOUSE", "mass": 27371.0, "length": 250, "protein_name": "Homeobox protein Hox-D4", "gene_name": "Hoxd4", "organism": "Mouse", "refseq_name": "homeobox protein Hox-D4", "refseq_ac": "NP_034599", "gene_names_uniprotkb": "Hoxd4; Hox-4.2; Hoxd-4", "gene_names_refseq": "6030436D05Rik; Hox-4.2; Hox-5.1; Hoxd4", "protein_names_uniprotkb": "Homeobox protein Hox-D4; Homeobox protein Hox-4.2; Homeobox protein Hox-5.1", "protein_names_refseq": "homeo box D4; homeobox protein Hox-4.2; homeobox protein Hox-5.1; homeobox protein Hox-D4", "tax_id": 10090, "disease": "leukemia (Disease Ontology:DOID:1240)", "pathway": " (mmu:15436)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1348361;2898782;7791786;7907418;9360992", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ASN3;P97451;Q3UXL6", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0030054 cell junction", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation;GO:0009952 anterior/posterior pattern specification;GO:0048704 embryonic skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P10628-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13504-1", "uniprot_id": "IL1R1_MOUSE", "mass": 66698.0, "length": 576, "protein_name": "Interleukin-1 receptor type 1", "gene_name": "Il1r1", "organism": "Mouse", "refseq_name": "interleukin-1 receptor type 1 isoform 1 precursor", "refseq_ac": "NP_032388", "gene_names_uniprotkb": "Il1r1; Il-1r1; Il1ra", "gene_names_refseq": "CD121a; CD121b; IL-1R-1; IL-1R-alpha; IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1; Il1r1", "protein_names_uniprotkb": "Interleukin-1 receptor type 1; 3.2.2.6; CD121 antigen-like family member A; IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1; Interleukin-1 receptor alpha; Interleukin-1 receptor type I; p80", "protein_names_refseq": "CD121 antigen-like family member A; IL-1 receptor alpha chain; interleukin-1 receptor alpha; interleukin-1 receptor type 1 isoform 1 precursor; interleukin-1 receptor type 1", "tax_id": 10090, "disease": "chronic recurrent multifocal osteomyelitis (Disease Ontology:DOID:0060645); COVID-19 (Disease Ontology:DOID:0080600); cholesteatoma of middle ear (Disease Ontology:DOID:10964); pulpitis (Disease Ontology:DOID:11121); severe acute respiratory syndrome (Disease Ontology:DOID:2945); systemic scleroderma (Disease Ontology:DOID:418); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:16177); (R-MMU-9020702)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10854325;15062642;1828344;22778412;2969618;37315560;7775431", "class_list": "", "function": "Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity)., [UniProtKB, UniProtKB]; Unable to mediate canonical IL-1 signaling. Cooperates with IL1RAP isoform 3 to mediate IL1B-induced neuronal activity including IL1B-potentiated NMDA-induced calcium influx mediated by Akt kinase activation., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.2.5;2.4.2.31;3.2.2.6;2.4.99.20;3.2.2.-;2.7.11.1", "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0002020 protease binding;GO:0019966 interleukin-1 binding;GO:0004908 interleukin-1 receptor activity;GO:0004909 interleukin-1, type I, activating receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:2000661 positive regulation of interleukin-1-mediated signaling pathway;GO:0006954 inflammatory response;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P13504-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13597-1", "uniprot_id": "ICAM1_MOUSE", "mass": 58844.0, "length": 537, "protein_name": "Intercellular adhesion molecule 1", "gene_name": "Icam1", "organism": "Mouse", "refseq_name": "intercellular adhesion molecule 1 precursor", "refseq_ac": "NP_034623", "gene_names_uniprotkb": "Icam1", "gene_names_refseq": "CD54; Icam-1; Icam1; Ly-47; MALA-2", "protein_names_uniprotkb": "Intercellular adhesion molecule 1; ICAM-1; MALA-2; MyD10", "protein_names_refseq": "intercellular adhesion molecule 1 precursor; myD10", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); colitis (Disease Ontology:DOID:0060180); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Graves ophthalmopathy (Disease Ontology:DOID:0081120); Prinzmetal angina (Disease Ontology:DOID:0111151); venous insufficiency (Disease Ontology:DOID:10128); aortic atherosclerosis (Disease Ontology:DOID:10230); pleurisy (Disease Ontology:DOID:10247); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); allergic conjunctivitis (Disease Ontology:DOID:11204); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic disease (Disease Ontology:DOID:1205); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); Graves' disease (Disease Ontology:DOID:12361); malaria (Disease Ontology:DOID:12365); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); mesenteric vascular occlusion (Disease Ontology:DOID:13252); biliary atresia (Disease Ontology:DOID:13608); rheumatic fever (Disease Ontology:DOID:1586); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); brain infarction (Disease Ontology:DOID:3454); cerebral infarction (Disease Ontology:DOID:3526); pulmonary fibrosis (Disease Ontology:DOID:3770); bronchus carcinoma (Disease Ontology:DOID:3904); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); hyperglycemia (Disease Ontology:DOID:4195); brain edema (Disease Ontology:DOID:4724); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); pneumonia (Disease Ontology:DOID:552); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); localized scleroderma (Disease Ontology:DOID:8472); rheumatic myocarditis (Disease Ontology:DOID:8481); bullous pemphigoid (Disease Ontology:DOID:8506); chronic ulcer of skin (Disease Ontology:DOID:8549); Hodgkin's lymphoma (Disease Ontology:DOID:8567); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); hyperhomocysteinemia (Disease Ontology:DOID:9279); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); iridocyclitis (Disease Ontology:DOID:9383); multiple myeloma (Disease Ontology:DOID:9538); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:15894); (R-MMU-198933); (R-MMU-216083)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;1362180;16877748;1690380;19349973;21474822;2479693;2573511;26495903;2762164;34428180;39627609;9207125", "class_list": "glycogene", "function": "Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1., [UniProtKB, UniProtKB]; This gene encodes an integral membrane protein that binds leukocyte adhesion protein LFA-1. It participates in the innate immune response. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 10, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 10, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 10, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 45, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 87, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q61828", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0044877 protein-containing complex binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:1900027 regulation of ruffle assembly;GO:0022614 membrane to membrane docking;GO:0061028 establishment of endothelial barrier;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0002457 T cell antigen processing and presentation", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P13597-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17950-1", "uniprot_id": "IER2_MOUSE", "mass": 24459.0, "length": 221, "protein_name": "Immediate early response gene 2 protein", "gene_name": "Ier2", "organism": "Mouse", "refseq_name": "immediate early response gene 2 protein", "refseq_ac": "NP_034629", "gene_names_uniprotkb": "Ier2", "gene_names_refseq": "Ch1; Ier2; Pip92", "protein_names_uniprotkb": "Immediate early response gene 2 protein; CHX1; Cycloheximide-induced gene protein; Growth factor-inducible immediate early protein; Pip92; Proline-rich-induced protein 92; T-lymphocyte-activated protein", "protein_names_refseq": "CHX1; T-lymphocyte-activated protein; cycloheximide-induced gene protein; growth factor-inducible immediate early protein; immediate early response gene 2 protein; proline-rich-induced protein 92", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); childhood acute myeloid leukemia (Disease Ontology:DOID:0070323); melanoma (Disease Ontology:DOID:1909); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:15936)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14747749;22120713;2247083;2308934;34611309;8083220", "class_list": "", "function": "DNA-binding protein that seems to act as a transcription factor (By similarity). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; IER2-induced senescence drives melanoma invasion through osteopontin., [RefSeq, PubMed]; Relief of contact inhibition was associated with translocation of the Ier2 protein from the cytoplasm to the nucleus in both 3T3 fibroblasts and 1AS tumor cells, [RefSeq, PubMed]; Shows a rapid and long-lasting induction after cerebral ischemia; induces cell death in primary neurons and displays several hallmarks of pro-apoptotic activity upon overexpression, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TD12;Q64251;Q8BME8;Q99M25", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation;GO:0048870 cell motility;GO:0071774 response to fibroblast growth factor", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P17950-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20067-1", "uniprot_id": "ID1_MOUSE", "mass": 17914.0, "length": 168, "protein_name": "DNA-binding protein inhibitor ID-1", "gene_name": "Id1", "organism": "Mouse", "refseq_name": "DNA-binding protein inhibitor ID-1 isoform 2", "refseq_ac": "NP_034625", "gene_names_uniprotkb": "Id1; Id-1; Idb1; Id", "gene_names_refseq": "D2Wsu140e; Id1; Idb1; bHLHb24", "protein_names_uniprotkb": "DNA-binding protein inhibitor ID-1; Inhibitor of DNA binding 1; Inhibitor of differentiation 1", "protein_names_refseq": "DNA-binding protein inhibitor ID-1 isoform 2; DNA-binding protein inhibitor ID-1; inhibitor of differentiation 1", "tax_id": 10090, "disease": "cholestasis (Disease Ontology:DOID:13580); primary pulmonary hypertension (Disease Ontology:DOID:14557); glaucoma (Disease Ontology:DOID:1686); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (R-MMU-2559585)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11940648;15451666;16516211;16556596;19217292;2156629;21750661;34428180;8765747", "class_list": "", "function": "Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61101;Q9D897", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0003714 transcription corepressor activity;GO:0070628 proteasome binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P20067-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20615-1", "uniprot_id": "HXB9_MOUSE", "mass": 28015.0, "length": 250, "protein_name": "Homeobox protein Hox-B9", "gene_name": "Hoxb9", "organism": "Mouse", "refseq_name": "homeobox protein Hox-B9", "refseq_ac": "NP_032296", "gene_names_uniprotkb": "Hoxb9; Hox-2.5; Hoxb-9", "gene_names_refseq": "Hox-2.5; Hoxb9", "protein_names_uniprotkb": "Homeobox protein Hox-B9; Homeobox protein Hox-2.5", "protein_names_refseq": "homeo box B9; homeobox protein Hox-2.5; homeobox protein Hox-B9", "tax_id": 10090, "disease": "", "pathway": " (mmu:15417)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1360646;2566383;2567250;8105876", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A9Z6", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0009954 proximal/distal pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20615-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23812-1", "uniprot_id": "HXD12_MOUSE", "mass": 29198.0, "length": 268, "protein_name": "Homeobox protein Hox-D12", "gene_name": "Hoxd12", "organism": "Mouse", "refseq_name": "homeobox protein Hox-D12", "refseq_ac": "NP_032300", "gene_names_uniprotkb": "Hoxd12; Hox-4.7; Hoxd-12", "gene_names_refseq": "Hox-4.7; Hox-5.6; Hoxd12", "protein_names_uniprotkb": "Homeobox protein Hox-D12; Homeobox protein Hox-4.7; Homeobox protein Hox-5.6", "protein_names_refseq": "homeo box D12; homeobox protein Hox-4.7; homeobox protein Hox-5.6; homeobox protein Hox-D12", "tax_id": 10090, "disease": "clubfoot (Disease Ontology:DOID:11836)", "pathway": " (mmu:15432)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1676674;38663984", "class_list": "", "function": "Exome sequencing of 1190 non-syndromic clubfoot cases reveals HOXD12 as a novel disease gene. Publication Status: Online-Only, [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSN0", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0001501 skeletal system development;GO:0042733 embryonic digit morphogenesis;GO:0007389 pattern specification process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P23812-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25085-1", "uniprot_id": "IL1RA_MOUSE", "mass": 20274.0, "length": 178, "protein_name": "Interleukin-1 receptor antagonist protein", "gene_name": "Il1rn", "organism": "Mouse", "refseq_name": "interleukin-1 receptor antagonist protein isoform 2 precursor", "refseq_ac": "NP_001034790", "gene_names_uniprotkb": "Il1rn; Il-1ra", "gene_names_refseq": "F630041P17Rik; IL-1ra; Il1rn", "protein_names_uniprotkb": "Interleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; IL1 inhibitor; IRAP", "protein_names_refseq": "IL-1RN; IL1 inhibitor; IRAP; interleukin-1 receptor antagonist protein isoform 2 precursor; interleukin-1 receptor antagonist protein", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); Muckle-Wells syndrome (Disease Ontology:DOID:0050854); stroke (Disease Ontology:DOID:0051061); interleukin-1 receptor antagonist deficiency (Disease Ontology:DOID:0061225); herpes simplex virus keratitis (Disease Ontology:DOID:0080158); lupus nephritis (Disease Ontology:DOID:0080162); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); keratoconus (Disease Ontology:DOID:10126); dry eye syndrome (Disease Ontology:DOID:10140); pleurisy (Disease Ontology:DOID:10247); silicosis (Disease Ontology:DOID:10325); common cold (Disease Ontology:DOID:10459); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); pleural tuberculosis (Disease Ontology:DOID:106); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); IgA vasculitis (Disease Ontology:DOID:11123); allergic conjunctivitis (Disease Ontology:DOID:11204); corneal neovascularization (Disease Ontology:DOID:11382); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pyelonephritis (Disease Ontology:DOID:11400); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); listeriosis (Disease Ontology:DOID:11573); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); cicatricial pemphigoid (Disease Ontology:DOID:11656); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); morbid obesity (Disease Ontology:DOID:11981); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); Sjogren's syndrome (Disease Ontology:DOID:12894); crescentic glomerulonephritis (Disease Ontology:DOID:13139); Behcet's disease (Disease Ontology:DOID:13241); pulmonary sarcoidosis (Disease Ontology:DOID:13406); anterior uveitis (Disease Ontology:DOID:1407); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); pleural disease (Disease Ontology:DOID:1532); depressive disorder (Disease Ontology:DOID:1596); vascular disease (Disease Ontology:DOID:178); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); hairy cell leukemia (Disease Ontology:DOID:285); glomerulonephritis (Disease Ontology:DOID:2921); bronchiolitis (Disease Ontology:DOID:2942); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); bronchus carcinoma (Disease Ontology:DOID:3904); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); Schnitzler syndrome (Disease Ontology:DOID:4371); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); ureteral obstruction (Disease Ontology:DOID:5199); pneumonia (Disease Ontology:DOID:552); proteinuria (Disease Ontology:DOID:576); fibromyalgia (Disease Ontology:DOID:631); myositis (Disease Ontology:DOID:633); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); periodontitis (Disease Ontology:DOID:824); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); learning disability (Disease Ontology:DOID:8927); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary eosinophilia (Disease Ontology:DOID:9498); multiple myeloma (Disease Ontology:DOID:9538); encephalitis (Disease Ontology:DOID:9588); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); dacryocystitis (Disease Ontology:DOID:9938); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16181); (R-MMU-9020702)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "1828262;1828896;1830498;1834470;21750661;28528544;31611644;35332327;38875998;8003626;9550387", "class_list": "", "function": "Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Exosome microRNA-125a-5p derived from epithelium promotes M1 macrophage polarization by targeting IL1RN in chronic obstructive pulmonary disease., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 92, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70207", "ec_number_list": "", "go_molecular_function": "GO:0005152 interleukin-1 receptor antagonist activity;GO:0005150 interleukin-1, type I receptor binding;GO:0045352 interleukin-1 type I receptor antagonist activity;GO:0045353 interleukin-1 type II receptor antagonist activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0001660 fever generation;GO:2000660 negative regulation of interleukin-1-mediated signaling pathway;GO:0006629 lipid metabolic process;GO:0006954 inflammatory response;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P25085-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28575-1", "uniprot_id": "IPP_MOUSE", "mass": 65216.0, "length": 584, "protein_name": "Actin-binding protein IPP", "gene_name": "Ipp", "organism": "Mouse", "refseq_name": "actin-binding protein IPP isoform a", "refseq_ac": "NP_032415", "gene_names_uniprotkb": "Ipp; Mipp", "gene_names_refseq": "D4Jhu8; Ipp; Mipp", "protein_names_uniprotkb": "Actin-binding protein IPP; IPP; Intracisternal A particle-promoted polypeptide; Murine IAP-promoted placenta-expressed protein; Protein MIPP", "protein_names_refseq": "actin-binding protein IPP isoform a; actin-binding protein IPP; intracisternal A particle-promoted polypeptide; murine IAP-promoted placenta-expressed protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:16351)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11536049;1905535;1906605;22872234;25428506;25605945;30084848;30779550;31219806;34203471;34428180", "class_list": "", "function": "May play a role in organizing the actin cytoskeleton., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2M0", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P28575-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31313-1", "uniprot_id": "HXC11_MOUSE", "mass": 33708.0, "length": 304, "protein_name": "Homeobox protein Hox-C11", "gene_name": "Hoxc11", "organism": "Mouse", "refseq_name": "homeobox protein Hox-C11", "refseq_ac": "NP_001020013", "gene_names_uniprotkb": "Hoxc11; Hox-3.7; Hoxc-11", "gene_names_refseq": "Hox-3.7; Hoxc11", "protein_names_uniprotkb": "Homeobox protein Hox-C11; Homeobox protein Hox-3.7", "protein_names_refseq": "homeo box C11; homeobox protein Hox-3.7; homeobox protein Hox-C11", "tax_id": 10090, "disease": "", "pathway": " (mmu:109663)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1683707", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EI74", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001759 organ induction;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P31313-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32043-1", "uniprot_id": "HXC5_MOUSE", "mass": 24992.0, "length": 222, "protein_name": "Homeobox protein Hox-C5", "gene_name": "Hoxc5", "organism": "Mouse", "refseq_name": "homeobox protein Hox-C5", "refseq_ac": "NP_783857", "gene_names_uniprotkb": "Hoxc5; Hox-3.4; Hoxc-5", "gene_names_refseq": "Hox-3.4; Hox-6.2; Hoxc5", "protein_names_uniprotkb": "Homeobox protein Hox-C5; Homeobox protein Hox-3.4; Homeobox protein Hox-6.2", "protein_names_refseq": "homeo box C5; homeobox protein Hox-3.4; homeobox protein Hox-6.2; homeobox protein Hox-C5", "tax_id": 10090, "disease": "", "pathway": " (mmu:15424)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1976088;8903739", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJW4", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030054 cell junction", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0048706 embryonic skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P32043-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43432-1", "uniprot_id": "IL12B_MOUSE", "mass": 38235.0, "length": 335, "protein_name": "Interleukin-12 subunit beta", "gene_name": "Il12b", "organism": "Mouse", "refseq_name": "interleukin-12 subunit beta precursor", "refseq_ac": "NP_001290173", "gene_names_uniprotkb": "Il12b", "gene_names_refseq": "Il-12b; Il-12p40; Il12b; Il12p40; p40", "protein_names_uniprotkb": "Interleukin-12 subunit beta; CLMF p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p40; IL-12B", "protein_names_refseq": "CLMF p40; IL-12 p40 subunit; IL-12 subunit p40; IL-23 subunit p40; cytotoxic lymphocyte maturation factor 40 kDa subunit; interleukin-12 p40 subunit; interleukin-12 subunit beta precursor; interleukin-12 subunit beta", "tax_id": 10090, "disease": "salmonellosis (Disease Ontology:DOID:0060859); immunodeficiency 29 (Disease Ontology:DOID:0111950); anogenital venereal wart (Disease Ontology:DOID:11168); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (mmu:16160); (R-MMU-9020591); (R-MMU-9020933)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10438970;11114383;11923845;1350290;25428506;27802388;28011936;29187734;34374750;8647196", "class_list": "", "function": "Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis., [UniProtKB, PubMed]; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC., [UniProtKB]; This gene encodes the beta subunit p40 of the Interleukin 12 (IL-12) family of cytokines. Members of the IL-12 family form heterodimers consisting of heavy and light subunits linked by disulfide bonds. The product of this gene, p40, is a subunit of interleukins IL-12 and IL-23. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9QUM1", "ec_number_list": "", "go_molecular_function": "GO:0045519 interleukin-23 receptor binding;GO:0005143 interleukin-12 receptor binding;GO:0042164 interleukin-12 alpha subunit binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0070743 interleukin-23 complex;GO:0043514 interleukin-12 complex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0032946 positive regulation of mononuclear cell proliferation;GO:0045063 T-helper 1 cell differentiation;GO:0051142 positive regulation of NK T cell proliferation;GO:0050709 negative regulation of protein secretion;GO:0032693 negative regulation of interleukin-10 production", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P43432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50207-1", "uniprot_id": "HXC13_MOUSE", "mass": 35193.0, "length": 328, "protein_name": "Homeobox protein Hox-C13", "gene_name": "Hoxc13", "organism": "Mouse", "refseq_name": "homeobox protein Hox-C13", "refseq_ac": "NP_034594", "gene_names_uniprotkb": "Hoxc13; Hoxc-13", "gene_names_refseq": "Hoxc13; N", "protein_names_uniprotkb": "Homeobox protein Hox-C13", "protein_names_refseq": "homeobox protein Hox-C13; naked", "tax_id": 10090, "disease": "ectodermal dysplasia 9 (Disease Ontology:DOID:0111656)", "pathway": " (mmu:15422)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11290294;16835220;7959778", "class_list": "", "function": "Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53Z78;Q920I7", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035878 nail development;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P50207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97431-1", "uniprot_id": "IRF6_MOUSE", "mass": 53111.0, "length": 467, "protein_name": "Interferon regulatory factor 6", "gene_name": "Irf6", "organism": "Mouse", "refseq_name": "interferon regulatory factor 6", "refseq_ac": "NP_058547", "gene_names_uniprotkb": "Irf6", "gene_names_refseq": "E230028I05Rik; Irf6; mirf6", "protein_names_uniprotkb": "Interferon regulatory factor 6; IRF-6", "protein_names_refseq": "IRF-6; interferon regulatory factor 6", "tax_id": 10090, "disease": "popliteal pterygium syndrome (Disease Ontology:DOID:0060055); Van der Woude syndrome (Disease Ontology:DOID:0060239); orofacial cleft 6 (Disease Ontology:DOID:0080593); syndactyly (Disease Ontology:DOID:11193); cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (mmu:54139)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12219090;17041603;18212048;19036739;21574244;31578523;34428180;38604478", "class_list": "", "function": "Interferon regulatory factor 6 (IRF6) determines intestinal epithelial cell development and immunity., [RefSeq, PubMed]; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91VD0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045177 apical part of cell", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P97431-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60766-1", "uniprot_id": "IRGM1_MOUSE", "mass": 46552.0, "length": 409, "protein_name": "Immunity-related GTPase family M protein 1", "gene_name": "Irgm1", "organism": "Mouse", "refseq_name": "immunity-related GTPase family M protein 1 isoform 1", "refseq_ac": "NP_032352", "gene_names_uniprotkb": "Irgm1; Ifi1; Iigp3; Irgm", "gene_names_refseq": "Ifggd3; Ifi1; Iigp3; Iipg3; Irgm1; Irgm", "protein_names_uniprotkb": "Immunity-related GTPase family M protein 1; 3.6.5.-; Interferon-inducible GTPase 3; Interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47; LRG-47", "protein_names_refseq": "LPS-stimulated RAW 264.7 macrophage protein 47; immunity related GTPase m1; immunity-related GTPase family M protein 1 isoform 1; immunity-related GTPase family M protein 1; interferon-gamma-inducible GTPase Ifggd3 protein; interferon-inducible protein 1", "tax_id": 10090, "disease": "inflammatory bowel disease 19 (Disease Ontology:DOID:0110890); tuberculosis (Disease Ontology:DOID:399)", "pathway": " (mmu:15944)", "pathway_count": 1, "publication_count": 44, "publication_id_list": "11457893;14576437;14707092;15294976;15607973;15908352;16339555;17911638;17982087;18371424;18806793;19144319;19620982;19920210;20072621;21633090;21757726;22645316;22874556;23785284;24751652;24788674;25428506;26740625;27098192;27439214;27443879;28154172;30084848;30612879;31599954;32152506;32453761;32715615;33510463;34428180;34467632;35197566;35820727;36629440;37453647;38501887;38759815;7561525", "class_list": "", "function": "A potential early-atheroprotective target: Irgm1 mediates lymphangiogenesis through LEC autophagy by Tfeb translocation. Erratum:[Biochim Biophys Acta Mol Basis Dis. 2025 Mar;1871(3):167610. doi: 10.1016/j.bbadis.2024.167610. PMID: 39665974], [RefSeq, PubMed]; A role is established for LRG-47 in host control of mycobacteria; in the context of the IFN-gamma response to persistent infection, LRG-47 can have downstream regulatory effects on lymphocyte survival., [RefSeq, PubMed]; Immunity-related GTPase that plays important roles in innate immunity and inflammatory response (PubMed:11457893, PubMed:14576437, PubMed:14707092, PubMed:15908352, PubMed:16339555, PubMed:17911638, PubMed:17982087, PubMed:19620982, PubMed:19920210). Acts as a dynamin-like protein that binds to intracellular membranes and promotes remodeling and trafficking of those membranes (PubMed:19620982, PubMed:27098192). Required for clearance of acute protozoan and bacterial infections by interacting with autophagy and lysosome regulatory proteins, thereby promoting the fusion of phagosomes with lysosomes for efficient degradation of cargo including microbes (PubMed:11457893, PubMed:14576437, PubMed:14707092, PubMed:15607973, PubMed:15908352, PubMed:16339555, PubMed:17982087, PubMed:19620982, PubMed:19920210, PubMed:21757726, PubMed:22874556, PubMed:24751652, PubMed:32453761). Regulates selective autophagy, including xenophagy and mitophagy, both directly and indirectly (PubMed:15607973, PubMed:21757726). Directly regulates autophagy by acting as a molecular adapter that promotes the coassembly of the core autophagy machinery to mediate antimicrobial defense: Irgm1 (1) activates AMPK, which in turn phosphorylates ULK1 and BECN1 to induce autophagy, (2) promotes the coassembly of ULK1 and BECN1, enhancing BECN1-interacting partners and (3) influences the composition of the BECN1 complex, by competing with the negative regulators BCL2 and RUBCN, to trigger autophagy (By similarity). Also activates autophagy by promoting recruitment of STX17 to autophagosomes (By similarity). In collaboration with ATG8 proteins, regulate lysosomal biogenesis, a fundamental process for any autophagic pathway, by promoting TFEB dephosphorylation (By similarity). Also modulates autophagy by assisting with autophagosome formation and preventing lysosomal deacidification (PubMed:21757726). Regulates autophagy by affecting mitochondrial fusion and fission (PubMed:24751652). Also involved in M1 macrophage activation for the production of proinflammatory cytokines (PubMed:15908352, PubMed:27439214, PubMed:27443879). While activating autophagy, acts as a key negative regulator of the inflammatory and interferon responses both by (1) promoting mitophagy and (2) mediating autophagy-dependent degradation of effectors of the inflammatory response (PubMed:30612879, PubMed:33510463, PubMed:34467632). Promotes degradation of damaged and IFNG/IFN-gamma-stressed mitochondria via mitophagy, preventing cytosolic release of ligands that activate inflammation (PubMed:32715615, PubMed:33510463). Negatively regulates interferon-signaling in hematopoietic stem cells, preserving hematopoietic stem cell number and function (PubMed:18371424, PubMed:21633090). Promotes expansion of activated CD4(+) T-cells by inhibiting IFNG/IFN-gamma signaling, thereby preventing Ifng-mediated cell death of CD4(+) T-cells (PubMed:18806793). Acts as a suppressor of inflammation by promoting recruitment of inflammation effectors, such as CGAS, RIGI/RIG-I and NLRP3, to autophagosome membranes, leading to their SQSTM1/p62-dependent autophagic degradation (By similarity). Also directly inhibits assembly of the NLRP3 inflammasome by preventing the association between NLRP3 and PYCARD (By similarity). Acts as a negative regulator of antiviral innate immune response by suppressing the RIPK2-dependent pro-inflammatory response: mediates recruitment of RIPosomes, composed of RIPK2 and NOD1 or NOD2, to autophagosome membranes, promoting their SQSTM1/p62-dependent autophagic degradation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Irgm proteins attenuate inflammatory disease in mouse models of genital Chlamydia infection., [RefSeq, PubMed]; LRG-47 is a Golgi-associated protein in the IFN-stimulated cell, which is rapidly recruited to active plasma membrane upon phagocytosis and remains associated with phagosomes as they mature, [RefSeq, PubMed]; LRG-47 may serve as a critical vacuolar trafficking component used to dispose of intracellular pathogens like Mycobacterium tuberculosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJ73", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0001891 phagocytic cup;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0043032 positive regulation of macrophage activation;GO:0090140 regulation of mitochondrial fission;GO:0044546 NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "Q60766-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62386-1", "uniprot_id": "IL17_MOUSE", "mass": 17490.0, "length": 158, "protein_name": "Interleukin-17A", "gene_name": "Il17a", "organism": "Mouse", "refseq_name": "interleukin-17A precursor", "refseq_ac": "NP_034682", "gene_names_uniprotkb": "Il17a; Ctla8; Il17", "gene_names_refseq": "Ctla-8; Ctla8; IL-17A; IL-17; Il17a; Il17", "protein_names_uniprotkb": "Interleukin-17A; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; IL-17A; IL-17", "protein_names_refseq": "cytotoxic T-lymphocyte-associated antigen 8; interleukin-17A precursor", "tax_id": 10090, "disease": "cutaneous lupus erythematosus (Disease Ontology:DOID:0050169); colitis (Disease Ontology:DOID:0060180); ileitis (Disease Ontology:DOID:0060189); COVID-19 (Disease Ontology:DOID:0080600); childhood-onset asthma (Disease Ontology:DOID:0080815); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); leprosy (Disease Ontology:DOID:1024); pleurisy (Disease Ontology:DOID:10247); tuberculoid leprosy (Disease Ontology:DOID:1025); hypertension (Disease Ontology:DOID:10763); lepromatous leprosy (Disease Ontology:DOID:10887); lipoid nephrosis (Disease Ontology:DOID:10966); trachoma (Disease Ontology:DOID:11265); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); cystic fibrosis (Disease Ontology:DOID:1485); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); Mycobacterium avium complex disease (Disease Ontology:DOID:2755); asthma (Disease Ontology:DOID:2841); bronchiolitis (Disease Ontology:DOID:2942); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); periodontal disease (Disease Ontology:DOID:3388); plague (Disease Ontology:DOID:3482); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); acne (Disease Ontology:DOID:6543); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); myocarditis (Disease Ontology:DOID:820); periapical periodontitis (Disease Ontology:DOID:823); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); cutaneous leishmaniasis (Disease Ontology:DOID:9111); acute myocardial infarction (Disease Ontology:DOID:9408); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:16171)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11441109;16200068;16990136;17372004;17470641;17911633;18025225;18157131;19144317;19262671;20364087;21946434;23255360;26431948;26735852;27795421;27923703;28709803;32973764;8654948;8877732", "class_list": "", "function": "Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:18025225, PubMed:19144317, PubMed:26431948). Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16200068, PubMed:17911633, PubMed:19144317, PubMed:26431948). Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (PubMed:18025225). In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines (PubMed:18025225, PubMed:27923703). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (PubMed:18157131). Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance (PubMed:17372004, PubMed:20364087, PubMed:28709803). Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation (PubMed:17470641, PubMed:23255360). Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis (PubMed:26431948). As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release (PubMed:28709803). In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317). Involved in antiviral host defense through various mechanisms (PubMed:21946434, PubMed:26735852, PubMed:27795421). Enhances immunity against West Nile virus by promoting T cell cytotoxicity (PubMed:27795421). May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung (PubMed:21946434). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (PubMed:26735852)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; IL-17 contributes to joint destruction during collagen-induced arthritis in an IL-1-independent manner and represents a target for the treatment of destructive arthritis., [RefSeq, PubMed]; Infected apoptotic cells are a critical component of the innate immune signals instructing T(H)17 differentiation, and point to pathogens particularly adept at triggering apoptosis that might preferentially induce T(H)17-mediated immunity, [RefSeq, PubMed]; This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 49, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q60971", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032747 positive regulation of interleukin-23 production;GO:0006954 inflammatory response;GO:0007219 Notch signaling pathway;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q62386-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62424-1", "uniprot_id": "HXA13_MOUSE", "mass": 39567.0, "length": 386, "protein_name": "Homeobox protein Hox-A13", "gene_name": "Hoxa13", "organism": "Mouse", "refseq_name": "homeobox protein Hox-A13", "refseq_ac": "NP_032290", "gene_names_uniprotkb": "Hoxa13; Hox-1.10", "gene_names_refseq": "Hd; Hox-1.10; Hoxa13", "protein_names_uniprotkb": "Homeobox protein Hox-A13; Homeobox protein Hox-1.10", "protein_names_refseq": "homeobox protein Hox-1.10; homeobox protein Hox-A13; hypodactyly", "tax_id": 10090, "disease": "hand-foot-genital syndrome (Disease Ontology:DOID:0060739); Guttmacher syndrome (Disease Ontology:DOID:0111544); hypospadias (Disease Ontology:DOID:10892)", "pathway": " (mmu:15398)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15617687;21750661;21829694;8673126", "class_list": "", "function": "Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0045111 intermediate filament cytoskeleton;GO:0005694 chromosome", "go_biological_process": "GO:0048619 embryonic hindgut morphogenesis;GO:0001570 vasculogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62424-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64345-1", "uniprot_id": "IFIT3_MOUSE", "mass": 47223.0, "length": 403, "protein_name": "Interferon-induced protein with tetratricopeptide repeats 3", "gene_name": "Ifit3", "organism": "Mouse", "refseq_name": "interferon-induced protein with tetratricopeptide repeats 3", "refseq_ac": "NP_034631", "gene_names_uniprotkb": "Ifit3; Garg49; Ifi49; Isg49", "gene_names_refseq": "Ifi49; Ifit3; P49", "protein_names_uniprotkb": "Interferon-induced protein with tetratricopeptide repeats 3; GARG-49; Glucocorticoid-attenuated response gene 49 protein; IFIT-3; IRG2; P49", "protein_names_refseq": "GARG-49; IFIT-3; IRG2; glucocorticoid-attenuated response gene 49 protein; interferon-induced protein with tetratricopeptide repeats 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:15959)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17079283;20950130;30084848;34428180;38232539;39305055;8207206;8660659", "class_list": "", "function": "Expression increased significantly during LCMV and WNV infection, being widespread and localized predominantly to common as well as distinct neuronal populations in the brain., [RefSeq, PubMed]; IFIT3 mediates TBK1 phosphorylation to promote activation of pDCs and exacerbate systemic sclerosis in mice., [RefSeq, PubMed]; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2 (By similarity)., [UniProtKB]; Knockdown of IFIT3 ameliorates multiple sclerosis via selectively regulating M1 polarization of microglia in an experimental autoimmune encephalomyelitis model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99L62", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0009617 response to bacterium;GO:0009615 response to virus;GO:0035634 response to stilbenoid", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q64345-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64385-1", "uniprot_id": "I11RA_MOUSE", "mass": 46655.0, "length": 432, "protein_name": "Interleukin-11 receptor subunit alpha-1", "gene_name": "Il11ra1", "organism": "Mouse", "refseq_name": "interleukin-11 receptor subunit alpha-1 precursor", "refseq_ac": "NP_001156873", "gene_names_uniprotkb": "Il11ra1; Etl2; Il11ra", "gene_names_refseq": "GP130; Il-11ra; Il11ra1; Il11ra2; Il11ra; NR1", "protein_names_uniprotkb": "Interleukin-11 receptor subunit alpha-1; Enhancer trap locus homolog 2; Etl-2; IL-11 receptor subunit alpha-1; IL-11R subunit alpha-1; IL-11R-alpha-1; IL-11RA1; NR-1; NR1; Novel cytokine receptor 1", "protein_names_refseq": "IL-11 receptor subunit alpha-1; IL-11R subunit alpha-1; IL-11R-alpha-1; IL-11RA1; Il-11ra-alpha; NR-1; enhancer trap locus homolog 2; etl-2; interleukin 11 receptor, alpha chain 1; interleukin 11 receptor, alpha chain 2; interleukin-11 receptor subunit alpha-1 precursor; locus 2; novel cytokine receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16157); (R-MMU-6788467)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21741611;26876177;38468436;7813775;7957045;8662802;8973540;9373251", "class_list": "", "function": "Inhibiting IL11RA to mitigate hepatic metastasis in skin cutaneous melanoma: Comprehensive insights from in vitro and in vivo investigations., [RefSeq, PubMed]; Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth., [UniProtKB]; Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AMS4;Q6NSQ0", "ec_number_list": "", "go_molecular_function": "GO:0004921 interleukin-11 receptor activity;GO:0019970 interleukin-11 binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0001890 placenta development;GO:0032502 developmental process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q64385-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80SS5-1", "uniprot_id": "IFNAC_MOUSE", "mass": 21752.0, "length": 189, "protein_name": "Interferon alpha-12", "gene_name": "Ifna12", "organism": "Mouse", "refseq_name": "interferon alpha-12 precursor", "refseq_ac": "NP_796335", "gene_names_uniprotkb": "Ifna12", "gene_names_refseq": "If1ai4; Ifna12", "protein_names_uniprotkb": "Interferon alpha-12; IFN-alpha-12", "protein_names_refseq": "IFN alpha 12; interferon 1ai4; interferon alpha-12 precursor", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); common cold (Disease Ontology:DOID:10459); anogenital venereal wart (Disease Ontology:DOID:11168); sarcoidosis (Disease Ontology:DOID:11335); Crimean-Congo hemorrhagic fever (Disease Ontology:DOID:12287); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); melioidosis (Disease Ontology:DOID:5052); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:242519); (R-MMU-909733); (R-MMU-912694)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15233997;15254193;17451966", "class_list": "", "function": "Data show that murine interferon-alpha12 is a protein with all the biological traits of a type I interferon., [RefSeq, PubMed]; Novel ifna12 was identified in mouse chromosome 4., [RefSeq, PubMed]; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80SS5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGI3-1", "uniprot_id": "INSI1_MOUSE", "mass": 28213.0, "length": 259, "protein_name": "Insulin-induced gene 1 protein", "gene_name": "Insig1", "organism": "Mouse", "refseq_name": "insulin-induced gene 1 protein", "refseq_ac": "NP_705746", "gene_names_uniprotkb": "Insig1", "gene_names_refseq": "1810013C12Rik; Insig-1; Insig1", "protein_names_uniprotkb": "Insulin-induced gene 1 protein; INSIG-1", "protein_names_refseq": "INSIG-1 membrane protein; insulin-induced gene 1 protein", "tax_id": 10090, "disease": "steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:231070)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12242332;12869692;15073165;16100574;16955138;25428506;26311497;28849786;30084848;33722690;34428180;39136964", "class_list": "", "function": "Insig-1 expression restricts lipogenesis in mature adipocytes and blocks differentiation in preadipocytes, [RefSeq, PubMed]; Insulin-Induced Gene 1-Enhance Secretion of BMSC Exosome Enriched in miR-132-3p Promoting Wound Healing in Diabetic Mice., [RefSeq, PubMed]; Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:16100574). Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (Probable). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (PubMed:16100574). In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (By similarity). Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139 (By similarity). Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Results define Insig proteins 1 and 2 as essential elements of the feedback inhibition system of cholesterol synthesis in mouse liver., [RefSeq, PubMed]; Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression., [RefSeq, PubMed]; The regulation of Insig-1 by PPARgamma agonists could in turn regulate SREBP processing and thus couple insulin sensitizers with the regulation of lipid homeostasis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RSM6;Q3UAX9;Q3UX30", "ec_number_list": "", "go_molecular_function": "GO:0008142 oxysterol binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0032937 SREBP-SCAP-Insig complex", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0008203 cholesterol metabolic process;GO:0032869 cellular response to insulin stimulus;GO:0042472 inner ear morphogenesis;GO:0045717 negative regulation of fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BGI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MS3-1", "uniprot_id": "MP17L_MOUSE", "mass": 22180.0, "length": 194, "protein_name": "Mpv17-like protein", "gene_name": "Mpv17l", "organism": "Mouse", "refseq_name": "mpv17-like protein isoform 3", "refseq_ac": "NP_001276491", "gene_names_uniprotkb": "Mpv17l", "gene_names_refseq": "M-LP; Mpv17l", "protein_names_uniprotkb": "Mpv17-like protein; M-LP", "protein_names_refseq": "mpv17-like protein isoform 3; mpv17-like protein", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 3 (Disease Ontology:DOID:0080121); mitochondrial DNA depletion syndrome 6 (Disease Ontology:DOID:0080125); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:93734)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11327696;12471025;15541722;18772386;20231359;21750661;34883249;37851308", "class_list": "", "function": "Deficiency of M-LP/Mpv17L leads to development of beta-cell hyperplasia and improved glucose tolerance via activation of the Wnt and TGF-beta pathways., [RefSeq, PubMed]; Identify Mpv17l as a unique interacting protein and regulator of HtrA2 protease mediating antioxidant and antiapoptotic function in mitochondria, [RefSeq, PubMed]; In mice, M-LPs is expressed exclusively in kidneys after 6 weeks. Transfection with M-LPS up-regulates SOD2 and down-regulates cellular glutathione peroxidase (Gpx1) and plasma glutathione peroxidase (Gpx3) gene expression, [RefSeq, PubMed]; Knockout of M-LP/Mpv17L, a newly identified atypical PDE, induces physiological afferent cardiac hypertrophy in mice., [RefSeq, PubMed]; Participates in reactive oxygen species metabolism, [RefSeq, PubMed]; Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes (PubMed:12471025, PubMed:15541722). Protective against the mitochondrial apoptotic cascade (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWD2;Q8CI14", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0016020 membrane", "go_biological_process": "GO:0010730 negative regulation of hydrogen peroxide biosynthetic process;GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:0072593 reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99MS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06336-1", "uniprot_id": "IGHE_MOUSE", "mass": 47321.0, "length": 421, "protein_name": "Immunoglobulin heavy constant epsilon", "gene_name": "IGHE; Ighe", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "IGHE; Ighe", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy constant epsilon; Ig epsilon chain C region", "protein_names_refseq": "", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); allergic rhinitis (Disease Ontology:DOID:4481); pulmonary eosinophilia (Disease Ontology:DOID:9498)", "pathway": " (R-MMU-2454202); (R-MMU-2730905); (R-MMU-2871796); (R-MMU-2871809); (R-MMU-2871837)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "18674755;21750661;31341647;6329728;6818553", "class_list": "", "function": "Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "P01856", "ec_number_list": "", "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042571 immunoglobulin complex, circulating;GO:0005576 extracellular region", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0042113 B cell activation;GO:0006958 complement activation, classical pathway;GO:1903131 mononuclear cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P06336-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BW10-1", "uniprot_id": "NOB1_MOUSE", "mass": 45464.0, "length": 403, "protein_name": "RNA-binding protein NOB1", "gene_name": "Nob1", "organism": "Mouse", "refseq_name": "RNA-binding protein NOB1", "refseq_ac": "NP_080553", "gene_names_uniprotkb": "Nob1", "gene_names_refseq": "1700021I09Rik; ART-4; Nob1p; Nob1; Psmd8bp1", "protein_names_uniprotkb": "RNA-binding protein NOB1; 3.1.-.-", "protein_names_refseq": "PSMD8 binding protein 1; RNA-binding protein NOB1; nin one binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67619); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;25428506;34428180;35820727", "class_list": "", "function": "May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; May play a role in mRNA degradation. Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPR3;Q9CRD7", "ec_number_list": "4.2.99.18;3.1.-.-;3.6.1.-;2.7.11.1;2.1.1.-;2.7.11.26", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0004521 RNA endonuclease activity;GO:0004519 endonuclease activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0007601 visual perception;GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BW10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q5C9-1", "uniprot_id": "NOLC1_MOUSE", "mass": 73698.0, "length": 702, "protein_name": "Nucleolar and coiled-body phosphoprotein 1", "gene_name": "Nolc1", "organism": "Mouse", "refseq_name": "nucleolar and coiled-body phosphoprotein 1 isoform B", "refseq_ac": "NP_001034440", "gene_names_uniprotkb": "Nolc1; Kiaa0035", "gene_names_refseq": "NOPP130; NOPP140; Nolc1; P130", "protein_names_uniprotkb": "Nucleolar and coiled-body phosphoprotein 1; 140 kDa nucleolar phosphoprotein; Nopp140", "protein_names_refseq": "140 kDa nucleolar phosphoprotein; nucleolar and coiled-body phosphoprotein 1 isoform B", "tax_id": 10090, "disease": "Treacher Collins syndrome (Disease Ontology:DOID:2908)", "pathway": " (mmu:70769)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11424213;15604408;17873058;19131326;19144319;21183079;21750661;23806337;25428506;26984997;28493459;34428180;34887587;37507081", "class_list": "", "function": "Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus., [RefSeq, PubMed]; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (By similarity). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (By similarity). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:11424213). It has intrinsic GTPase and ATPase activities (By similarity)., [UniProtKB, PubMed, UniProtKB]; UBF and Nopp140 dynamic redistribution between the two-cell and blastocyst stages (time of implantation) is correlated with morphological and structural modifications that occur in embryonic nucleolar compartments., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKZ9;Q3U6W2;Q3UBB6;Q3UI16;Q6ZQK6;Q8CE21", "ec_number_list": "", "go_molecular_function": "GO:0001093 TFIIB-class transcription factor binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046982 protein heterodimerization activity;GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0015030 Cajal body", "go_biological_process": "GO:0014029 neural crest formation;GO:0007000 nucleolus organization;GO:0006417 regulation of translation;GO:0008284 positive regulation of cell population proliferation;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "E9Q5C9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61161-1", "uniprot_id": "M4K2_MOUSE", "mass": 91265.0, "length": 821, "protein_name": "Mitogen-activated protein kinase kinase kinase kinase 2", "gene_name": "Map4k2", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase kinase kinase kinase 2 isoform 2", "refseq_ac": "NP_001278716", "gene_names_uniprotkb": "Map4k2; Rab8ip", "gene_names_refseq": "BL44; GCK; Map4k2; Rab8ip", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase kinase 2; 2.7.11.1; GCK; Germinal center kinase; MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; Rab8-interacting protein", "protein_names_refseq": "MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; RAB8 interacting protein; germinal center kinase; mitogen-activated protein kinase kinase kinase kinase 2 isoform 2; rab8-interacting protein", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:26412)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10026130;11316611;19246396;21183079;21750661;22411792;26495903;29187734;34428180;8643544", "class_list": "", "function": "Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:8643544). Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Also mediates the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031435 mitogen-activated protein kinase kinase kinase binding;GO:0008349 MAP kinase kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0045087 innate immune response;GO:0046330 positive regulation of JNK cascade;GO:0006903 vesicle targeting", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61161-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGF3-1", "uniprot_id": "MED16_MOUSE", "mass": 91786.0, "length": 828, "protein_name": "Mediator of RNA polymerase II transcription subunit 16", "gene_name": "Med16", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 16 isoform 1", "refseq_ac": "NP_001156748", "gene_names_uniprotkb": "Med16; MED16; Thrap5", "gene_names_refseq": "95kDa; A630083L04; DRIP92; Med16; Thrap5; Trap95", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 16; DRIP92; Mediator complex subunit 16; Thyroid hormone receptor-associated protein 5; Thyroid hormone receptor-associated protein complex 95 kDa component; Trap95; Vitamin D3 receptor-interacting protein complex 92 kDa component", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 16 isoform 1; mediator of RNA polymerase II transcription subunit 16; thyroid hormone receptor associated protein 5; thyroid hormone receptor-associated protein complex 95 kDa component; thyroid hormone receptor-associated protein, 95-kD subunit; vitamin D3 receptor-interacting protein complex 92 kDa component", "tax_id": 10090, "disease": "", "pathway": " (mmu:216154)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QM81", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046966 nuclear thyroid hormone receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PGF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI46-1", "uniprot_id": "NUDT3_MOUSE", "mass": 19030.0, "length": 168, "protein_name": "Diphosphoinositol polyphosphate phosphohydrolase 1", "gene_name": "Nudt3", "organism": "Mouse", "refseq_name": "diphosphoinositol polyphosphate phosphohydrolase 1 isoform 1", "refseq_ac": "NP_062811", "gene_names_uniprotkb": "Nudt3; Dipp1; Dipp", "gene_names_refseq": "1110011B09Rik; Dipp1; Dipp; Nudt3", "protein_names_uniprotkb": "Diphosphoinositol polyphosphate phosphohydrolase 1; 3.6.1.10; 3.6.1.52; 3.6.1.59; 3.6.1.61; 3.6.1.62; Ap6A hydrolase; DIPP-1; Diadenosine hexaphosphate hydrolase; Endopolyphosphatase; Nucleoside diphosphate-linked moiety X motif 3; Nudix motif 3; m7GpppN-mRNA hydrolase; m7GpppX diphosphatase; muDIPP1", "protein_names_refseq": "DIPP-1; ap6A hydrolase; diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1; diadenosine hexaphosphate hydrolase; diphosphoinositol polyphosphate phosphohydrolase 1 isoform 1; diphosphoinositol polyphosphate phosphohydrolase 1; endopolyphosphatase; m7GpppN-mRNA hydrolase; m7GpppX diphosphatase; nudix (nucleoside diphosphate linked moiety X)-type motif 3; nudix (nucleotide diphosphate linked moiety X)-type motif 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:56409); (R-MMU-1855167)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;15212765;21750661;22517741;22645316;23353937;26168034;26192747;32782141;34678516;35822049;36852467;40021952;40885482", "class_list": "", "function": "Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:15212765). InsP6 (inositol hexakisphosphate) is not a substrate (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates (By similarity). The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A (By similarity). Also able to hydrolyze 5- phosphoribose 1-diphosphate (By similarity). Acts as a negative regulator of the ERK1/2 pathway (PubMed:15212765). Acts as a decapping enzyme that can hydrolyze both monomethylated and unmethylated capped RNAs (PubMed:23353937). Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA (PubMed:23353937). Modulates the stability of a subset of mRNAs implicated in cell motility (By similarity). Divalent cations zinc, magnesium and manganese determine its substrate specificity (By similarity). Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions, diadenosine hexaphosphate hydrolase activity in the presence of manganese ions and endopolyphosphatase activity in the presence of zinc ions (By similarity). Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Ectopic expression of murine DIPP1 (muDIPP1)inhibits signal transduction through the ERK1/2 pathway., [RefSeq, PubMed]; Studies revealed abundant Nudt3 mRNA and protein expression in the mouse brain, including reward- and feeding-related regions of hypothalamus and amygdala, and Nudt3 mRNA expression was up-regulated in hypothalamus and brainstem of food-deprived mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B2KF68;Q6PG02;Q8BV71", "ec_number_list": "3.6.1.62;3.6.1.64;3.1.4.1;3.6.1.9;3.6.1.52;3.6.1.60;3.6.1.-;3.6.1.61;3.6.1.59;3.6.1.10", "go_molecular_function": "GO:0000298 endopolyphosphatase activity;GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity;GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity;GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity;GO:0052840 inositol diphosphate tetrakisphosphate diphosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0071543 diphosphoinositol polyphosphate metabolic process;GO:0071544 diphosphoinositol polyphosphate catabolic process;GO:1901907 diadenosine pentaphosphate catabolic process;GO:1901909 diadenosine hexaphosphate catabolic process;GO:1901911 adenosine 5'-(hexahydrogen pentaphosphate) catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9JI46-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TXT3-1", "uniprot_id": "SOSSC_MOUSE", "mass": 11411.0, "length": 104, "protein_name": "SOSS complex subunit C", "gene_name": "Inip", "organism": "Mouse", "refseq_name": "SOSS complex subunit C", "refseq_ac": "NP_001013595", "gene_names_uniprotkb": "Inip; Ssbip1", "gene_names_refseq": "1110054O05Rik; 2610312O17Rik; Inip; Ssbip1", "protein_names_uniprotkb": "SOSS complex subunit C; INTS3- and NABP-interacting protein; SOSS-C; SSB-interacting protein 1; Sensor of single-strand DNA complex subunit C; Sensor of ssDNA subunit C; Single-stranded DNA-binding protein-interacting protein 1", "protein_names_refseq": "SOSS complex subunit C; SOSS-C; SSB-interacting protein 1; sensor of single-strand DNA complex subunit C; sensor of ssDNA subunit C; single-stranded DNA-binding protein-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66209)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506", "class_list": "", "function": "Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AX81;B1AX82;Q3TEN1;Q8BTC7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0070876 SOSS complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination;GO:0044818 mitotic G2/M transition checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TXT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31695-1", "uniprot_id": "NOTC4_MOUSE", "mass": 206702.0, "length": 1964, "protein_name": "Neurogenic locus notch homolog protein 4", "gene_name": "Notch4", "organism": "Mouse", "refseq_name": "neurogenic locus notch homolog protein 4 precursor", "refseq_ac": "NP_035059", "gene_names_uniprotkb": "Notch4; Int-3; Int3", "gene_names_refseq": "Int-3; Int3; N4; Notch4", "protein_names_uniprotkb": "Neurogenic locus notch homolog protein 4; Notch 4", "protein_names_refseq": "Notch gene homolog 4; neurogenic locus notch homolog protein 4 precursor; neurogenic locus notch homolog protein 4", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); Alzheimer's disease (Disease Ontology:DOID:10652); dementia (Disease Ontology:DOID:1307); endometrial cancer (Disease Ontology:DOID:1380); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); hemangiopericytoma (Disease Ontology:DOID:264); systemic scleroderma (Disease Ontology:DOID:418); hemangioblastoma (Disease Ontology:DOID:5241); schizophrenia (Disease Ontology:DOID:5419); rheumatoid arthritis (Disease Ontology:DOID:7148); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (mmu:18132); (R-MMU-1912420); (R-MMU-350054); (R-MMU-9013700); (R-MMU-9604323)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10233982;11344305;11459941;11518718;1312643;14656967;15019995;21750661;8681805;9150355", "class_list": "", "function": "Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May regulate branching morphogenesis in the developing vascular system., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 3, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2CG28;O35442;O88314;O88316;Q62389;Q62390;Q9R1W9;Q9R1X0", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P31695-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1B7-1", "uniprot_id": "SEP11_MOUSE", "mass": 49695.0, "length": 431, "protein_name": "Septin-11", "gene_name": "Septin11", "organism": "Mouse", "refseq_name": "septin-11 isoform 3", "refseq_ac": "NP_001009818", "gene_names_uniprotkb": "Septin11; D5Ertd606e; Sept11", "gene_names_refseq": "6230410I01Rik; D5Ertd606e; Sept11; Septin11", "protein_names_uniprotkb": "Septin-11", "protein_names_refseq": "septin-11 isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:52398)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17546647;20181826;21750661;21824005;25153642;28528544;33300544;34428180;40684658", "class_list": "", "function": "Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB, UniProtKB]; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity)., [UniProtKB]; SEPT11 is involved in vesicle trafficking and may play a role in synaptic connectivity. Interestingly, mice that harbor a homozygous Sept11 null mutation, die in utero., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBA0;Q3TC24;Q5D0F0;Q6P2K5;Q6P6I0", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005940 septin ring;GO:0030424 axon;GO:0043197 dendritic spine", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0050807 regulation of synapse organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8C1B7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35710-1", "uniprot_id": "SOX5_MOUSE", "mass": 84090.0, "length": 763, "protein_name": "Transcription factor SOX-5", "gene_name": "Sox5", "organism": "Mouse", "refseq_name": "transcription factor SOX-5 isoform c", "refseq_ac": "NP_001230092", "gene_names_uniprotkb": "Sox5; Sox-5", "gene_names_refseq": "A730017D01Rik; Sox5", "protein_names_uniprotkb": "Transcription factor SOX-5", "protein_names_refseq": "SRY-box containing gene 5; transcription factor SOX-5 isoform c; transcription factor SOX-5", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); heart disease (Disease Ontology:DOID:114)", "pathway": " (mmu:20678)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11266597;11702786;12414734;1396566;14993235;15529345;21750661;26150426;26525805;27923061;30084848;35820727;8078769;9714725;9755172", "class_list": "", "function": "Transcription factor involved in chondrocytes differentiation and cartilage formation (PubMed:11702786, PubMed:1396566, PubMed:14993235, PubMed:15529345, PubMed:8078769). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1 (PubMed:11702786, PubMed:26150426, PubMed:9755172). Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate (PubMed:11702786, PubMed:14993235, PubMed:15529345, PubMed:26150426). Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes (PubMed:14993235). Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts (PubMed:14993235). Binds to the proximal promoter region of the myelin protein MPZ gene (PubMed:26525805)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88184;O89018", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P35710-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6UGQ3-1", "uniprot_id": "SG2B2_MOUSE", "mass": 12857.0, "length": 114, "protein_name": "Secretoglobin family 2B member 2", "gene_name": "Scgb2b2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Scgb2b2; Abpe", "gene_names_refseq": "", "protein_names_uniprotkb": "Secretoglobin family 2B member 2; Androgen-binding protein epsilon; Lacrimal androgen-binding protein epsilon", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:381970)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15623751;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6UGQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04692-1", "uniprot_id": "SMRCD_MOUSE", "mass": 116451.0, "length": 1021, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1", "gene_name": "Smarcad1", "organism": "Mouse", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 isoform 2", "refseq_ac": "NP_001240321", "gene_names_uniprotkb": "Smarcad1; Etl1; Kiaa1122", "gene_names_refseq": "D6Pas1; Etl1; Smarcad1; etl-1; mKIAA1122", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1; 3.6.4.-; ATP-dependent helicase SMARCAD1; Enhancer trap locus homolog 1; Etl-1", "protein_names_refseq": "ATP-dependent helicase SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 isoform 2; SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1; enhancer trap locus 1; enhancer trap locus homolog 1", "tax_id": 10090, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); BASAN syndrome (Disease Ontology:DOID:0080725); adermatoglyphia (Disease Ontology:DOID:0111357)", "pathway": " (mmu:13990)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10415348;1489724;17242355;17622165;18675275;21183079;21549307;21750661;21952136;25428506;30084848;31219806;32160911;32234239;34428180;37761933;39627609;8219362", "class_list": "", "function": "Protein that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Combines the ATP-dependent ability to exchange histones, with the chaperone-like ATP-independent activity to deposit histones and assemble nucleosomes. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing., [UniProtKB, UniProtKB]; Role of the ATP-dependent chromatin remodeling enzyme Fun30/Smarcad1 in the regulation of mRNA splicing., [RefSeq, PubMed]; Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium. Publication Status: Online-Only, [RefSeq, PubMed]; The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC and Architectural Proteins in Human and Mouse. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGK6;Q3UYR6", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0035861 site of double-strand break", "go_biological_process": "GO:0000018 regulation of DNA recombination;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051304 chromosome separation;GO:0000729 DNA double-strand break processing", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q04692-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54824-1", "uniprot_id": "IL16_MOUSE", "mass": 141435.0, "length": 1322, "protein_name": "Pro-interleukin-16", "gene_name": "Il16", "organism": "Mouse", "refseq_name": "pro-interleukin-16 isoform 2", "refseq_ac": "NP_034681", "gene_names_uniprotkb": "Il16", "gene_names_refseq": "Il16; mKIAA4048", "protein_names_uniprotkb": "Pro-interleukin-16; LCF; Lymphocyte chemoattractant factor", "protein_names_refseq": "pro-interleukin-16 isoform 2; pro-interleukin-16", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); prostate cancer (Disease Ontology:DOID:10283); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); periodontal disease (Disease Ontology:DOID:3388); rhinitis (Disease Ontology:DOID:4483); borna disease (Disease Ontology:DOID:5154); chronic fatigue syndrome (Disease Ontology:DOID:8544)", "pathway": " (mmu:16170); (R-MMU-449836)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10479680;21750661;26740625;29237092;31120548;31219806;35820727;38508138;38544694;9510557;9637508", "class_list": "", "function": "IL-16 enhanced lung allergic inflammatory response may be associated with the up-regulation of IgE and the promotion of Th2 and Th17 cytokine production., [RefSeq, PubMed]; Interleukin-16 is increased in obesity and alters adipogenesis and inflammation in vitro. Publication Status: Online-Only, [RefSeq, PubMed]; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4., [UniProtKB]; Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane., [UniProtKB]; Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells., [UniProtKB]; Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O70236;Q3TEM4;Q5DTR5;Q8R0G5;Q9QZP6", "ec_number_list": "", "go_molecular_function": "GO:0042609 CD4 receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0016607 nuclear speck", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0006351 DNA-templated transcription;GO:0032755 positive regulation of interleukin-6 production;GO:0051924 regulation of calcium ion transport;GO:0050729 positive regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O54824-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CC84-1", "uniprot_id": "LYSM4_MOUSE", "mass": 31660.0, "length": 293, "protein_name": "LysM and putative peptidoglycan-binding domain-containing protein 4", "gene_name": "Lysmd4", "organism": "Mouse", "refseq_name": "lysM and putative peptidoglycan-binding domain-containing protein 4 isoform A", "refseq_ac": "NP_001177980", "gene_names_uniprotkb": "Lysmd4", "gene_names_refseq": "4930506D23Rik; Lysmd4", "protein_names_uniprotkb": "LysM and putative peptidoglycan-binding domain-containing protein 4", "protein_names_refseq": "lysM and putative peptidoglycan-binding domain-containing protein 4 isoform A; lysM and putative peptidoglycan-binding domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:75099)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFQ8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CC84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88735-1", "uniprot_id": "MAP7_MOUSE", "mass": 82022.0, "length": 730, "protein_name": "Ensconsin", "gene_name": "Map7", "organism": "Mouse", "refseq_name": "ensconsin isoform 2", "refseq_ac": "NP_001185564", "gene_names_uniprotkb": "Map7; Mtap7", "gene_names_refseq": "E-MAP-115; MAP-7; Map7; Mtap7; mshi; mste; ste", "protein_names_uniprotkb": "Ensconsin; E-MAP-115; Epithelial microtubule-associated protein of 115 kDa; MAP-7; Microtubule-associated protein 7", "protein_names_refseq": "ensconsin isoform 2; ensconsin; epithelial microtubule-associated protein of 115 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:17761)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12755995;14517216;21183079;21750661;30784582;31085585;31391261;31599954;34428180;9745708", "class_list": "", "function": "MAP7 binds to the acetylated and stable region of individual microtubules and rescues microtubule polymerization in developing sensory neurons., [RefSeq, PubMed]; MAP7 does not alter the force exerted by a single kinesin-1 motor, but instead increases its binding rate to the microtubule, [RefSeq, PubMed]; MAP7D2 interacts with all three kinesin-1 family members and accumulates in the proximal axon through its N-terminal microtubule-binding domain. Depletion of MAP7D2 results in reduced axonal cargo entry., [RefSeq, PubMed]; Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0B9;Q7TQL9;Q80V60", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0006970 response to osmotic stress;GO:0007283 spermatogenesis;GO:0008283 cell population proliferation;GO:0009566 fertilization;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O88735-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CW42-1", "uniprot_id": "MARC1_MOUSE", "mass": 37979.0, "length": 340, "protein_name": "Mitochondrial amidoxime-reducing component 1", "gene_name": "Mtarc1", "organism": "Mouse", "refseq_name": "mitochondrial amidoxime-reducing component 1", "refseq_ac": "NP_001277202", "gene_names_uniprotkb": "Mtarc1; Marc1; Mosc1", "gene_names_refseq": "1300013F15Rik; Marc1; Mosc1; Mtarc1", "protein_names_uniprotkb": "Mitochondrial amidoxime-reducing component 1; 1.7.-.-; MOSC domain-containing protein 1; Moco sulfurase C-terminal domain-containing protein 1; Molybdenum cofactor sulfurase C-terminal domain-containing protein 1; mARC1", "protein_names_refseq": "MOCO sulphurase C-terminal domain containing 1; MOSC domain-containing protein 1, mitochondrial; mitochondrial amidoxime-reducing component 1; moco sulfurase C-terminal domain-containing protein 1; molybdenum cofactor sulfurase C-terminal domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66112); (R-MMU-211945)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12865426;21750661;34428180;37453647;38340654;38437227;38619429;38696369", "class_list": "", "function": "Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction., [UniProtKB, UniProtKB]; Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse. Publication Status: Online-Only, [RefSeq, PubMed]; Fatty liver disease protective MTARC1 p.A165T variant reduces the protein stability of MTARC1., [RefSeq, PubMed]; Liver-specific mitochondrial amidoxime-reducing component 1 (Mtarc1) knockdown protects the liver from diet-induced MASH in multiple mouse models. Publication Status: Online-Only, [RefSeq, PubMed]; MARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2L6", "ec_number_list": "1.7.-.-;1.6.2.2", "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0008940 nitrate reductase activity;GO:0030170 pyridoxal phosphate binding;GO:0043546 molybdopterin cofactor binding;GO:0050421 nitrite reductase (NO-forming) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:1903958 nitric-oxide synthase complex", "go_biological_process": "GO:0006809 nitric oxide biosynthetic process;GO:0042126 nitrate metabolic process;GO:0070458 cellular detoxification of nitrogen compound", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CW42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0JNU3-1", "uniprot_id": "LPP60_MOUSE", "mass": 60595.0, "length": 564, "protein_name": "60 kDa lysophospholipase", "gene_name": "Aspg", "organism": "Mouse", "refseq_name": "60 kDa lysophospholipase", "refseq_ac": "NP_001074638", "gene_names_uniprotkb": "Aspg", "gene_names_refseq": "A530050D06Rik; Aspg; Gm690", "protein_names_uniprotkb": "60 kDa lysophospholipase; 3.1.1.5; L-asparagine amidohydrolase; Lysophospholipase-transacylase; PAF acetylhydrolase; Platelet-activating factor acetylhydrolase", "protein_names_refseq": "60 kDa lysophospholipase [Includes: L-asparaginase; 60 kDa lysophospholipase; asparaginase homolog; lysophospholipase-transacylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:104816); (R-MMU-8963693)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;21750661;25428506;31219806", "class_list": "", "function": "Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (By similarity). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.1;3.1.1.47;3.1.1.5;3.1.1.-;3.1.1.4;2.3.1.43;3.1.1.32;3.1.1.3;3.1.2.2;3.1.2.22;3.1.2.-;3.1.1.13;3.1.1.6;2.3.1.-;3.4.19.5;2.3.1.149;3.1.1.23;3.1.-.-;3.1.4.-", "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004067 asparaginase activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "", "go_biological_process": "GO:0006528 asparagine metabolic process;GO:0016042 lipid catabolic process;GO:0006520 amino acid metabolic process;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0JNU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXU0-1", "uniprot_id": "MED10_MOUSE", "mass": 15661.0, "length": 135, "protein_name": "Mediator of RNA polymerase II transcription subunit 10", "gene_name": "Med10", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 10 isoform 1", "refseq_ac": "NP_613062", "gene_names_uniprotkb": "Med10; D13Wsu50e; MED10", "gene_names_refseq": "D13Wsu50e; Med10", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 10; Mediator complex subunit 10", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 10 isoform 1; mediator of RNA polymerase II transcription subunit 10; mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae)", "tax_id": 10090, "disease": "", "pathway": " (mmu:28077)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0W8;Q80VV0", "ec_number_list": "", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0019827 stem cell population maintenance;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CXU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZU0-1", "uniprot_id": "NUD13_MOUSE", "mass": 39137.0, "length": 352, "protein_name": "NAD(P)H pyrophosphatase NUDT13, mitochondrial", "gene_name": "Nudt13", "organism": "Mouse", "refseq_name": "NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 2", "refseq_ac": "NP_080617", "gene_names_uniprotkb": "Nudt13", "gene_names_refseq": "4933433B15Rik; Nudt13", "protein_names_uniprotkb": "NAD(P)H pyrophosphatase NUDT13, mitochondrial; 3.6.1.22; Nucleoside diphosphate-linked moiety X motif 13; Nudix motif 13", "protein_names_refseq": "NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 2; NAD(P)H pyrophosphatase NUDT13, mitochondrial; nucleoside diphosphate-linked moiety X motif 13; nudix (nucleoside diphosphate linked moiety X)-type motif 13; nudix motif 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:67725); (R-MMU-499943)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;28755312;31101919", "class_list": "", "function": "NAD(P)H pyrophosphatase that hydrolyzes NADH into NMNH and AMP, and NADPH into NMNH and 2',5'-ADP (PubMed:28755312). Has a marked preference for the reduced pyridine nucleotides (PubMed:28755312). Does not show activity toward NAD-capped RNAs; the NAD-cap is an atypical cap present at the 5'-end of some RNAs (PubMed:31101919)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXN4", "ec_number_list": "3.6.1.22;3.6.1.18;3.6.1.-;2.7.7.2;3.1.-.-", "go_molecular_function": "GO:0000210 NAD+ diphosphatase activity;GO:0046872 metal ion binding;GO:0035529 NADH pyrophosphatase activity;GO:0010943 NADPH pyrophosphatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8JZU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0F6-1", "uniprot_id": "ILKAP_MOUSE", "mass": 42774.0, "length": 392, "protein_name": "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "gene_name": "Ilkap", "organism": "Mouse", "refseq_name": "integrin-linked kinase-associated serine/threonine phosphatase 2C isoform 1", "refseq_ac": "NP_075832", "gene_names_uniprotkb": "Ilkap", "gene_names_refseq": "0710007A14Rik; 1600009O09Rik; Ilkap; PP2C-DELTA", "protein_names_uniprotkb": "Integrin-linked kinase-associated serine/threonine phosphatase 2C; 3.1.3.16; ILKAP", "protein_names_refseq": "integrin-linked kinase-associated serine/threonine phosphatase 2C isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67444)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18635968;21750661;31663018;34428180", "class_list": "", "function": "PP2Cdelta, via dephosphorylation of ATM, suppresses DNA damage-induced BRCA1 phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity)., [UniProtKB]; These studies demonstrate the importance for keratinocyte proliferation of ILK regulation through changes in its subcellular localization, and establish ILKAP and CRM1 as pivotal modulators of ILK subcellular distribution and activity in these cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05CC3", "ec_number_list": "3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0033262 regulation of nuclear cell cycle DNA replication;GO:0007165 signal transduction;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R0F6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88559-1", "uniprot_id": "MEN1_MOUSE", "mass": 67501.0, "length": 611, "protein_name": "Menin", "gene_name": "Men1", "organism": "Mouse", "refseq_name": "menin isoform a", "refseq_ac": "NP_001161960", "gene_names_uniprotkb": "Men1", "gene_names_refseq": "Men1", "protein_names_uniprotkb": "Menin", "protein_names_refseq": "menin isoform a; menin", "tax_id": 10090, "disease": "multiple endocrine neoplasia type 1 (Disease Ontology:DOID:10017); hyperparathyroidism (Disease Ontology:DOID:13543); congenital heart disease (Disease Ontology:DOID:1682); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); prolactinoma (Disease Ontology:DOID:5394); gastrinoma (Disease Ontology:DOID:5577); growth hormone secreting pituitary adenoma (Disease Ontology:DOID:6255); duodenal gastrinoma (Disease Ontology:DOID:7959)", "pathway": " (mmu:17283); (R-MMU-201722); (R-MMU-2173796); (R-MMU-381426); (R-MMU-5626467); (R-MMU-8957275); (R-MMU-9772755)", "pathway_count": 7, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10341092;10524203;10612420;11158604;16415155;21750661;31219806;34428180;36210013;38609433;9824159;9893060;9989505", "class_list": "", "function": "Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression (By similarity). May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U491;Q8CI72;Q91UZ7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051219 phosphoprotein binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0002051 osteoblast fate commitment;GO:0046621 negative regulation of organ growth;GO:0071559 response to transforming growth factor beta;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O88559-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P7W0-1", "uniprot_id": "SENP6_MOUSE", "mass": 127013.0, "length": 1132, "protein_name": "Sentrin-specific protease 6", "gene_name": "Senp6", "organism": "Mouse", "refseq_name": "sentrin-specific protease 6 isoform 1", "refseq_ac": "NP_001298039", "gene_names_uniprotkb": "Senp6; Kiaa0797; Susp1", "gene_names_refseq": "2810017C20Rik; E130319N12Rik; Senp6; Susp1; mKIAA0797", "protein_names_uniprotkb": "Sentrin-specific protease 6; 3.4.22.-; SUMO-1-specific protease 1; Sentrin/SUMO-specific protease SENP6", "protein_names_refseq": "SUMO-1-specific protease 1; SUMO/sentrin specific protease 6; sentrin-specific protease 6 isoform 1; sentrin-specific protease 6; sentrin/SUMO-specific protease SENP6", "tax_id": 10090, "disease": "", "pathway": " (mmu:215351)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21183079;21750661;23825957;25428506;29321472;30084848;31219806;32782141;34158860", "class_list": "", "function": "Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6., [RefSeq, PubMed]; Postnatal loss of the desumoylase SUMO1/sentrin-specific peptidase 6 (SENP6) causes premature aging. OCP-specific SENP6 knockout mice exhibit smaller skeletons, with elevated apoptosis and cell senescence in OCPs and chondrocytes. SENP6 interacts with, desumoylates, and stabilizes TRIM28, suppressing p53 activity. Erratum:[Nat Commun. 2018 Feb 8;9(1):646. doi: 10.1038/s41467-018-03177-0. PMID: 29422621] Publication Status: Online-Only, [RefSeq, PubMed]; Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Also desumoylates RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QN09;Q6ZQ43;Q8BK94;Q8BUL4", "ec_number_list": "", "go_molecular_function": "GO:0070139 SUMO-specific endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0099523 presynaptic cytosol", "go_biological_process": "GO:0070646 protein modification by small protein removal;GO:0006508 proteolysis;GO:0016925 protein sumoylation;GO:0090169 regulation of spindle assembly;GO:0090234 regulation of kinetochore assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6P7W0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WV70-1", "uniprot_id": "NOC2L_MOUSE", "mass": 85424.0, "length": 747, "protein_name": "Nucleolar complex protein 2 homolog", "gene_name": "Noc2l", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Noc2l; Nir", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleolar complex protein 2 homolog; NOC2-like protein; Novel INHAT repressor; Protein NOC2 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-6804756)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16322561;19144319;21183079;21750661;25428506;30084848;34428180", "class_list": "", "function": "Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VE16", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0042393 histone binding;GO:0002039 p53 binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0042273 ribosomal large subunit biogenesis;GO:0034644 cellular response to UV", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WV70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DFW4-1", "uniprot_id": "NOP58_MOUSE", "mass": 60343.0, "length": 536, "protein_name": "Nucleolar protein 58", "gene_name": "Nop58", "organism": "Mouse", "refseq_name": "nucleolar protein 58 isoform 1", "refseq_ac": "NP_061356", "gene_names_uniprotkb": "Nop58; Nol5", "gene_names_refseq": "MSSP; Nol5; Nop58; SIK; nop5", "protein_names_uniprotkb": "Nucleolar protein 58; MSSP; Nucleolar protein 5; SIK-similar protein", "protein_names_refseq": "NOP58 ribonucleoprotein homolog; SIK similar protein; nucleolar protein 58 isoform 1; nucleolar protein 58", "tax_id": 10090, "disease": "", "pathway": " (mmu:55989); (R-MMU-4570464); (R-MMU-6791226)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10864044;17242355;19144319;21183079;21540332;21750661;22282469;22645316;24788674;25153642;28135057;28528544;29187734;31219806;34428180;34887587;35820727;36210013", "class_list": "", "function": "Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sik-SP, an early estradiol-responsive nucleolar protein, is necessary to induce Eestradiol-dependent estrogen receptor alpha-mediated appropriate physiologic responses in the uterus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70396;Q3UYX9;Q3UZA3;Q8C8Y7", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0030515 snoRNA binding;GO:0001094 TFIID-class transcription factor complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0001650 fibrillar center;GO:0015030 Cajal body", "go_biological_process": "GO:0048254 snoRNA localization;GO:0042274 ribosomal small subunit biogenesis;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q6DFW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQC8-1", "uniprot_id": "SPG21_MOUSE", "mass": 34952.0, "length": 308, "protein_name": "Maspardin", "gene_name": "Spg21", "organism": "Mouse", "refseq_name": "maspardin isoform 1", "refseq_ac": "NP_613050", "gene_names_uniprotkb": "Spg21", "gene_names_refseq": "ACP33; BM-019; D9Wsu18e; GL010; MAST; Spg21", "protein_names_uniprotkb": "Maspardin; Acid cluster protein 33; Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog", "protein_names_refseq": "acid cluster protein 33; maspardin isoform 1; maspardin; spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog; spastic paraplegia 21 homolog", "tax_id": 10090, "disease": "Mast syndrome (Disease Ontology:DOID:0060245); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:27965)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11113139;20661613;21750661;26978163;35820727", "class_list": "", "function": "Mast syndrome gene SPG21 in mice has a role in hind limb function and axon branching in cultured cortical neurons, [RefSeq, PubMed]; May play a role as a negative regulatory factor in CD4-dependent T-cell activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study showed that the loss of maspardin attenuates the growth, maturation, and axonal branching of cortical neurons to promote progressive neuronal dysfunction; impairment of sensory motor neurons in SPG21-/- mice; and that SPG21-/- cortical neurons failed to respond to EGF-induced growth and maturation, which is confirmed by the attenuated expression of a subset of EGFR target genes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U658;Q3UDT7;Q8C1Y7", "ec_number_list": "", "go_molecular_function": "GO:0042609 CD4 receptor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030140 trans-Golgi network transport vesicle;GO:0005737 cytoplasm", "go_biological_process": "GO:0007626 locomotory behavior;GO:0050905 neuromuscular process;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0048668 collateral sprouting;GO:0060173 limb development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZA6-1", "uniprot_id": "SOCS4_MOUSE", "mass": 49918.0, "length": 436, "protein_name": "Suppressor of cytokine signaling 4", "gene_name": "Socs4", "organism": "Mouse", "refseq_name": "suppressor of cytokine signaling 4", "refseq_ac": "NP_543119", "gene_names_uniprotkb": "Socs4; Socs7", "gene_names_refseq": "3110032M18Rik; A730004F22Rik; Socs4; Socs7", "protein_names_uniprotkb": "Suppressor of cytokine signaling 4; SOCS-4; SOCS-7; Suppressor of cytokine signaling 7", "protein_names_refseq": "SOCS-4; SOCS-7; suppressor of cytokine signaling 4; suppressor of cytokine signaling 7; suppressor of cytokine signalling 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67296)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17636018;21604262;21750661;22423360;34428180;36702633", "class_list": "", "function": "Identified is a conserved region of about 70 residues in the N-terminal domains of Socs4 and 5 that is predicted to be more ordered than the surrounding sequence., [RefSeq, PubMed]; In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance., [RefSeq, PubMed]; Negative regulation of the JAK/STAT pathway is controlled by SOCS4, which target members of negative feedback loops, to suppress follicle growth and development., [RefSeq, PubMed]; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity)., [UniProtKB]; Socs4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149F7;Q149F8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016567 protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0019221 cytokine-mediated signaling pathway;GO:0007175 negative regulation of epidermal growth factor-activated receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91ZA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMG8-1", "uniprot_id": "S2532_MOUSE", "mass": 35049.0, "length": 316, "protein_name": "Solute carrier family 25 member 32", "gene_name": "Slc25a32", "organism": "Mouse", "refseq_name": "solute carrier family 25 member 32", "refseq_ac": "NP_765990", "gene_names_uniprotkb": "Slc25a32; Mftc", "gene_names_refseq": "2610043O12Rik; Mftc; Slc25a32", "protein_names_uniprotkb": "Solute carrier family 25 member 32; Mitochondrial FAD transporter", "protein_names_refseq": "mitochondrial FAD transporter; mitochondrial folate transporter/carrier; solute carrier family 25 member 32", "tax_id": 10090, "disease": "multiple acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0060358)", "pathway": " (mmu:69906); (R-MMU-196757)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15140890;21750661;25428506;29666258;34428180;35727412", "class_list": "", "function": "Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis., [UniProtKB, PubMed, PubMed]; These data demonstrate that the loss of functional Slc25a32 results in cranial neural tube defects (NTDs) in mice and has also been observed in a human NTD patient., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCM5", "ec_number_list": "", "go_molecular_function": "GO:0008517 folic acid transmembrane transporter activity;GO:0015230 FAD transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:1904947 folate import into mitochondrion;GO:1990548 mitochondrial FAD transmembrane transport;GO:0006862 nucleotide transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BMG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810B7-1", "uniprot_id": "SLIK5_MOUSE", "mass": 107165.0, "length": 957, "protein_name": "SLIT and NTRK-like protein 5", "gene_name": "Slitrk5", "organism": "Mouse", "refseq_name": "SLIT and NTRK-like protein 5 isoform 1 precursor", "refseq_ac": "NP_942565", "gene_names_uniprotkb": "Slitrk5", "gene_names_refseq": "2610019D03Rik; Slitrk5", "protein_names_uniprotkb": "SLIT and NTRK-like protein 5", "protein_names_refseq": "SLIT and NTRK-like protein 5 isoform 1 precursor; SLIT and NTRK-like protein 5; slit and trk like gene 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:75409); (R-MMU-388844); (R-MMU-9013404); (R-MMU-9013423)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "14550773;21750661;25428506;33300544;34326333;34678516;35820727", "class_list": "", "function": "SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Suppresses neurite outgrowth., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9CT21", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0016020 membrane;GO:0043235 receptor complex;GO:0045202 synapse;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0072359 circulatory system development;GO:0007409 axonogenesis;GO:0030534 adult behavior;GO:0007268 chemical synaptic transmission;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q810B7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6TAW2-1", "uniprot_id": "SERP2_MOUSE", "mass": 7431.0, "length": 65, "protein_name": "Stress-associated endoplasmic reticulum protein 2", "gene_name": "Serp2", "organism": "Mouse", "refseq_name": "stress-associated endoplasmic reticulum protein 2 isoform 1", "refseq_ac": "NP_001153798", "gene_names_uniprotkb": "Serp2", "gene_names_refseq": "2810032E02Rik; Serp2", "protein_names_uniprotkb": "Stress-associated endoplasmic reticulum protein 2; Ribosome-associated membrane protein RAMP4-2", "protein_names_refseq": "ribosome-associated membrane protein RAMP4-2; stress-associated endoplasmic reticulum protein 2 isoform 1; stress-associated endoplasmic reticulum protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72661)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;31361958", "class_list": "", "function": "Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497L0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030968 endoplasmic reticulum unfolded protein response;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6TAW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0S9-1", "uniprot_id": "SNPC1_MOUSE", "mass": 44576.0, "length": 389, "protein_name": "snRNA-activating protein complex subunit 1", "gene_name": "Snapc1", "organism": "Mouse", "refseq_name": "snRNA-activating protein complex subunit 1 isoform 1", "refseq_ac": "NP_848479", "gene_names_uniprotkb": "Snapc1", "gene_names_refseq": "2700033G17Rik; 9630050P21Rik; Snapc1", "protein_names_uniprotkb": "snRNA-activating protein complex subunit 1; SNAPc 43 kDa subunit; SNAPc subunit 1; Small nuclear RNA-activating complex polypeptide 1; snRNA-activating protein complex 43 kDa subunit", "protein_names_refseq": "SNAPc 43 kDa subunit; SNAPc subunit 1; snRNA-activating protein complex 43 kDa subunit; snRNA-activating protein complex subunit 1 isoform 1; snRNA-activating protein complex subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75627); (R-MMU-6807505); (R-MMU-76071)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "19224205;20173027;21750661;21952136;31219806;34428180;36210013", "class_list": "", "function": "Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0019185 snRNA-activating protein complex", "go_biological_process": "GO:0042795 snRNA transcription by RNA polymerase II;GO:0042796 snRNA transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K0S9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R570-1", "uniprot_id": "SNP47_MOUSE", "mass": 46524.0, "length": 413, "protein_name": "Synaptosomal-associated protein 47", "gene_name": "Snap47", "organism": "Mouse", "refseq_name": "synaptosomal-associated protein 47 isoform 1", "refseq_ac": "NP_653104", "gene_names_uniprotkb": "Snap47", "gene_names_refseq": "1110031B06Rik; SNAP-47; Snap47", "protein_names_uniprotkb": "Synaptosomal-associated protein 47; SNAP-47; Synaptosomal-associated 47 kDa protein", "protein_names_refseq": "synaptosomal-associated 47 kDa protein; synaptosomal-associated protein 47 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67826)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16621800;21750661;28135057;28315936;28528544;33300544;33567284;34428180;40684658", "class_list": "", "function": "May play a role in intracellular membrane fusion., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SNAP-47 is a novel Qbc-SNARE with ubiquitous expression, [RefSeq, PubMed]; TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNK4;Q8BK87", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006887 exocytosis;GO:0060291 long-term synaptic potentiation;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane;GO:0016082 synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R570-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YR3-1", "uniprot_id": "SKDA1_MOUSE", "mass": 90309.0, "length": 822, "protein_name": "SKI/DACH domain-containing protein 1", "gene_name": "Skida1", "organism": "Mouse", "refseq_name": "SKI/DACH domain-containing protein 1", "refseq_ac": "NP_082593", "gene_names_uniprotkb": "Skida1; 2810030E01Rik", "gene_names_refseq": "2810030E01Rik; 5730507N06Rik; DLN-1; Skida1", "protein_names_uniprotkb": "SKI/DACH domain-containing protein 1; Protein DLN-1", "protein_names_refseq": "SKI/DACH domain-containing protein 1; protein DLN-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72668)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6PWY1;A6PWY2;Q9CSH2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80YR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99P69-1", "uniprot_id": "NUF2_MOUSE", "mass": 54594.0, "length": 463, "protein_name": "Kinetochore protein Nuf2", "gene_name": "Nuf2", "organism": "Mouse", "refseq_name": "kinetochore protein Nuf2", "refseq_ac": "NP_075773", "gene_names_uniprotkb": "Nuf2; Cdca1; Nuf2r", "gene_names_refseq": "2410003C07Rik; Cdca1; NUF2R; Nuf2", "protein_names_uniprotkb": "Kinetochore protein Nuf2; Cell division cycle-associated protein 1", "protein_names_refseq": "cell division cycle-associated protein 1; kinetochore protein Nuf2", "tax_id": 10090, "disease": "oral cavity carcinoma in situ (Disease Ontology:DOID:0050610); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:66977); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "11266451;21183079;21750661;22872234;26054848;31219806;33649389;34428180;36210013", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nuf2 is a critical regulator of meiotic cell cycle progression in mammalian oocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTK7;Q8VE05;Q9CST5", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000776 kinetochore;GO:0000940 outer kinetochore", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051383 kinetochore organization;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99P69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BU33-1", "uniprot_id": "HACL2_MOUSE", "mass": 68156.0, "length": 632, "protein_name": "2-hydroxyacyl-CoA lyase 2", "gene_name": "Hacl2; Ilvbl", "organism": "Mouse", "refseq_name": "2-hydroxyacyl-CoA lyase 2 isoform 2", "refseq_ac": "NP_776112", "gene_names_uniprotkb": "Hacl2; Ilvbl; Ilvbl", "gene_names_refseq": "5830463I21; Hacl2; Ilvbl", "protein_names_uniprotkb": "2-hydroxyacyl-CoA lyase 2; 4.1.2.-; Acetolactate synthase-like protein; IlvB-like protein", "protein_names_refseq": "2-hydroxyacyl-CoA lyase 2 isoform 2; acetolactate synthase-like protein; ilvB (bacterial acetolactate synthase)-like; ilvB-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:216136)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;34428180;35820727", "class_list": "", "function": "Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNZ4;Q3UZY5", "ec_number_list": "4.1.2.-;4.1.2.63", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0016829 lyase activity;GO:0030976 thiamine pyrophosphate binding;GO:0003984 acetolactate synthase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005948 acetolactate synthase complex", "go_biological_process": "GO:0001561 fatty acid alpha-oxidation;GO:0009099 L-valine biosynthetic process;GO:0009097 isoleucine biosynthetic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BU33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UA16-1", "uniprot_id": "SPC25_MOUSE", "mass": 26457.0, "length": 226, "protein_name": "Kinetochore protein Spc25", "gene_name": "Spc25", "organism": "Mouse", "refseq_name": "kinetochore protein Spc25 isoform 1", "refseq_ac": "NP_001186052", "gene_names_uniprotkb": "Spc25; Spbc25", "gene_names_refseq": "2600017H08Rik; 2610205L13Rik; Spbc25; Spc25", "protein_names_uniprotkb": "Kinetochore protein Spc25", "protein_names_refseq": "kinetochore protein Spc25 isoform 1; kinetochore protein Spc25; spindle pole body component 25 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66442); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "21084868;21750661", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Spc25 is required for chromosome alignment, spindle formation, and proper spindle checkpoint signaling during meiosis., [RefSeq, PubMed]; This gene encodes a component of the kinetochore-associated NDC80 protein complex, which is required for the mitotic spindle checkpoint and for microtubule-kinetochore attachment. During meiosis in mouse, the protein localizes to the germinal vesicle and then is associated with the chromosomes following germinal vesicle breakdown. Knockdown of this gene in oocytes results in precocious polar body extrusion, chromosome misalignment and aberrant spindle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D021;Q9D1K6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0000776 kinetochore;GO:0000940 outer kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UA16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V27-1", "uniprot_id": "MELPH_MOUSE", "mass": 65052.0, "length": 590, "protein_name": "Melanophilin", "gene_name": "Mlph", "organism": "Mouse", "refseq_name": "melanophilin", "refseq_ac": "NP_443748", "gene_names_uniprotkb": "Mlph; Ln; Slac2a", "gene_names_refseq": "2210418F23Rik; 5031433I09Rik; D1Wsu84e; Mlph; Slac-2a; l(1)-3Rk; l1Rk3; ln", "protein_names_uniprotkb": "Melanophilin; Exophilin-3; Leaden protein; SlaC2-a; Slp homolog lacking C2 domains a; Synaptotagmin-like protein 2a", "protein_names_refseq": "exophilin-3; leaden protein; melanophilin; slaC2-a; slp homolog lacking C2 domains a; synaptotagmin-like protein 2a", "tax_id": 10090, "disease": "Griscelli syndrome type 3 (Disease Ontology:DOID:0060834)", "pathway": " (mmu:171531); (R-MMU-9824585)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11327731;11504925;11887186;18940604;21750661;23798443;25428506;39083977", "class_list": "", "function": "MLPH is a novel adipogenic factor controlling redox homeostasis to inhibit lipid peroxidation in adipocytes., [RefSeq, PubMed]; Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFV7;Q99N53", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0017022 myosin binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm;GO:0042470 melanosome;GO:0001725 stress fiber", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006605 protein targeting;GO:0043473 pigmentation;GO:0032400 melanosome localization;GO:0030318 melanocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91V27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89090-1", "uniprot_id": "SP1_MOUSE", "mass": 80732.0, "length": 784, "protein_name": "Transcription factor Sp1", "gene_name": "Sp1", "organism": "Mouse", "refseq_name": "transcription factor Sp1", "refseq_ac": "NP_038700", "gene_names_uniprotkb": "Sp1", "gene_names_refseq": "1110003E12Rik; Sp1-1; Sp1", "protein_names_uniprotkb": "Transcription factor Sp1; Specificity protein 1", "protein_names_refseq": "specificity protein 1; transcription factor Sp1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20683); (R-MMU-2173796); (R-MMU-6807505); (R-MMU-9018519); (R-MMU-9762293)", "pathway_count": 5, "publication_count": 44, "publication_id_list": "10215616;11598016;14749383;1633330;16879824;17242355;18513490;18596307;19070619;19285002;19598243;20138838;21183079;21493720;21750661;22874425;23315940;24030830;25153642;25428506;25605945;25657638;27010859;27918959;28528544;29125738;30084848;30779550;33649389;34260942;34428180;34887587;38467599;38632598;38857058;38861834;38982418;39627609;40997131;41385373;7568082;7799962;9454706;9628590", "class_list": "", "function": "AMPK-SP1-Guided Dynein Expression Represents a New Energy-Responsive Mechanism and Therapeutic Target for Diabetic Nephropathy., [RefSeq, PubMed]; Inhibition of Foxp3 expression in the placenta of mice infected intraperitoneally by toxoplasma gondii tachyzoites: insights into the PPARgamma/miR-7b-5p/Sp1 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; P4HA2 promotes tumor progression and is transcriptionally regulated by SP1 in colorectal cancer., [RefSeq, PubMed]; SP1 regulates BMSC osteogenic differentiation through the miR-133a-3p/MAPK3 axis : SP1 regulates osteogenic differentiation of BMSCs. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity). Positively regulates the transcription of the core clock component BMAL1 (PubMed:24030830). Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (PubMed:27918959)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 6, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O89087;Q62251;Q64167", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex;GO:0000785 chromatin", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0043353 enucleate erythrocyte differentiation;GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0001701 in utero embryonic development;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "O89090-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30554-1", "uniprot_id": "MAS_MOUSE", "mass": 37055.0, "length": 324, "protein_name": "Proto-oncogene Mas", "gene_name": "Mas1", "organism": "Mouse", "refseq_name": "proto-oncogene Mas", "refseq_ac": "NP_032578", "gene_names_uniprotkb": "Mas1; Mas-1; Mas", "gene_names_refseq": "Mas-1; Mas1; MasR; Mgra", "protein_names_uniprotkb": "Proto-oncogene Mas", "protein_names_refseq": "MAS proto-oncogene; MAS1 oncogene; Mas receptor; Mas-related G protein-coupled receptor a; angiotensin-(1-7) receptor; proto-oncogene Mas", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); glaucoma (Disease Ontology:DOID:1686); congestive heart failure (Disease Ontology:DOID:6000); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (mmu:17171)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12829792;21750661;35979816;38097099;8001672;9268631;9565612", "class_list": "", "function": "ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis., [RefSeq, PubMed]; G protein-coupled receptor that plays key roles in the renin-angiotensin system (RAS) specifically in the protective, counter-regulatory arm of the RAS. Receptor mainly stimulated by angiotensin 1-7, which is a bioactive metabolite of the angiotensin produced by ACE2 (PubMed:12829792). Activation promotes nitric oxide via PI3K/Akt-eNOS pathway. Modulates also the MAPK, ERK1/2, and NF-kappa-B signaling. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. Acts as functional receptor for CXCL17 and induces chemotactic movement., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35944;Q8BHI8", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0008528 G protein-coupled peptide receptor activity;GO:0042277 peptide binding;GO:0001595 angiotensin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P30554-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CJ26-1", "uniprot_id": "NRADD_MOUSE", "mass": 24727.0, "length": 228, "protein_name": "Death domain-containing membrane protein NRADD", "gene_name": "Nradd", "organism": "Mouse", "refseq_name": "death domain-containing membrane protein NRADD", "refseq_ac": "NP_080288", "gene_names_uniprotkb": "Nradd", "gene_names_refseq": "2610311B09Rik; NRDD; NRH2; Nradd; PLAIDD", "protein_names_uniprotkb": "Death domain-containing membrane protein NRADD; NRH2; Neurotrophin receptor homolog-2; Neurotrophin receptor-alike death domain protein", "protein_names_refseq": "death domain-containing membrane protein NRADD; neurotrophin receptor homolog-2; neurotrophin receptor-alike death domain protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67169)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12728256;12843241;18624909;19407813;19656770;21750661;23935974;25093680;25428506;25443284;27775873", "class_list": "", "function": "Its reduction ameliorates cognitive deficits in Alzheimer disease., [RefSeq, PubMed]; Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR., [UniProtKB, PubMed, PubMed, PubMed]; P45 forms a complex with FADD and diminishes Fas-FADD mediated death signaling. Publication Status: Online-Only, [RefSeq, PubMed]; The NRADD conditional and complete knockout mouse lines generated are new and useful tools to study the physiological roles of NRADD., [RefSeq, PubMed]; The authors show that the mammalian p75NTR homologue NRH2 critically regulates the expression of sortilin on the neuronal cell surface and promotes p75NTR and sortilin receptor complex formation, rendering cells responsive to proneurotrophins., [RefSeq, PubMed]; These results suggest a mechanism involving both the transmembrane domain and the death domain of p45 to regulate p75-mediated signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVC1", "ec_number_list": "", "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0015026 coreceptor activity;GO:0005166 neurotrophin p75 receptor binding;GO:0005035 death receptor activity", "go_cellular_component": "GO:0032589 neuron projection membrane;GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006915 apoptotic process;GO:0007266 Rho protein signal transduction;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8CJ26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D552-1", "uniprot_id": "SPT17_MOUSE", "mass": 45503.0, "length": 379, "protein_name": "Spermatogenesis-associated protein 17", "gene_name": "Spata17", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 17 isoform 1", "refseq_ac": "NP_083124", "gene_names_uniprotkb": "Spata17; Srg11", "gene_names_refseq": "1700065F16Rik; 4930504I07Rik; 4930513F16Rik; MSRG-11; Spata17", "protein_names_uniprotkb": "Spermatogenesis-associated protein 17; Spermatogenesis-related protein 11", "protein_names_refseq": "spermatogenesis-associated protein 17 isoform 1; spermatogenesis-associated protein 17; spermatogenesis-related protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:74717)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15756417;16395525;21750661", "class_list": "", "function": "Flow cytometry analysis showed that the expression of Spata17 protein in the GC-1 cell line could accelerate GC-1 cell apoptosis [Spata17], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWA7;Q8BQE6", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D552-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ33-1", "uniprot_id": "LZTR1_MOUSE", "mass": 94476.0, "length": 837, "protein_name": "Leucine-zipper-like transcriptional regulator 1", "gene_name": "Lztr1", "organism": "Mouse", "refseq_name": "leucine-zipper-like transcriptional regulator 1 isoform 2", "refseq_ac": "NP_001318155", "gene_names_uniprotkb": "Lztr1; Tcfl2", "gene_names_refseq": "1200003E21Rik; Lztr1", "protein_names_uniprotkb": "Leucine-zipper-like transcriptional regulator 1; LZTR-1", "protein_names_refseq": "LZTR-1; leucine-zipper-like transcriptional regulator 1 isoform 2", "tax_id": 10090, "disease": "Noonan syndrome 2 (Disease Ontology:DOID:0060580); Noonan syndrome 10 (Disease Ontology:DOID:0060588); schwannomatosis 2 (Disease Ontology:DOID:0070481); stomach cancer (Disease Ontology:DOID:10534); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); glioblastoma (Disease Ontology:DOID:3068); neurilemmoma (Disease Ontology:DOID:3192); schwannomatosis (Disease Ontology:DOID:3204); Noonan syndrome (Disease Ontology:DOID:3490); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:66863)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16356934;21750661;25428506;30084848;30442762;31219806;31599954;34428180", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras GTPases (M-Ras/MRAS, K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) and Ras-like protein RIT1 (PubMed:30442762). Acts as a negative regulator of RAS-MAPK signaling by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762)., [UniProtKB, PubMed]; This gene encodes a member of the BR-C, ttk and bab-kelch superfamily that, in humans, localizes to the Golgi network and is associated with the ras / mitogen-activated protein kinase pathway. Loss-of-function mutations in the human ortholog are associated with glioblastoma multiforme, schwannomatosis, Noonan syndrome, and DiGeorge syndrome. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0012505 endomembrane system;GO:0055038 recycling endosome membrane;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CQ33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VIB3-1", "uniprot_id": "SIA10_MOUSE", "mass": 37854.0, "length": 329, "protein_name": "Type 2 lactosamine alpha-2,3-sialyltransferase", "gene_name": "St3gal6", "organism": "Mouse", "refseq_name": "type 2 lactosamine alpha-2,3-sialyltransferase isoform 1", "refseq_ac": "NP_061254", "gene_names_uniprotkb": "St3gal6; Siat10", "gene_names_refseq": "1700023B24Rik; Siat10; St3gal6; St3galVI", "protein_names_uniprotkb": "Type 2 lactosamine alpha-2,3-sialyltransferase; 2.4.3.6; CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; ST3Gal VI; ST3GalVI; Sialyltransferase 10", "protein_names_refseq": "CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; ST3Gal VI; sialyltransferase 10 (alpha-2,3-sialyltransferase VI); type 2 lactosamine alpha-2,3-sialyltransferase isoform 1; type 2 lactosamine alpha-2,3-sialyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:54613); (R-MMU-2022854); (R-MMU-4085001); (R-MMU-9037629)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22700726;38910494", "class_list": "glycogene;glycosyltransferase", "function": "Coordinated participation of both ST3Gal-VI and ST3Gal-IV in the synthesis of functional selectin ligands., [RefSeq, PubMed]; Sialyltransferase ST3GAL6 silencing reduces alpha2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Transfers the sialyl residue from CMP-N-acetyl-beta-neuraminate to the terminal galactose residue on sugar chains of glycoproteins and glycolipids. Its alpha-2,3-sialyltransferase activity is specific toward type II glycan chains (Galbeta1-4GlcNAc) on glycoproteins and glycolipids such as neolactosides nLc4Cer and nLc6Cer, whose sialyl-products serve as precursors for the Lewis X antigen (By similarity). Critically involved in the synthesis of functional selectin ligands needed for neutrophil recruitment during inflammation and lymphocyte homing to the lymph nodes (PubMed:22700726)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRN3;Q80UR7;Q9WVG2", "ec_number_list": "2.4.3.9;2.4.3.2;2.4.3.4;2.4.3.6", "go_molecular_function": "GO:0008373 sialyltransferase activity;GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0009247 glycolipid biosynthetic process;GO:0071354 cellular response to interleukin-6", "synthesized_glycan_count": 2417, "hit_score": 0.7, "record_id": "Q8VIB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUZ7-1", "uniprot_id": "SH3BG_MOUSE", "mass": 23102.0, "length": 214, "protein_name": "SH3 domain-binding glutamic acid-rich protein", "gene_name": "Sh3bgr", "organism": "Mouse", "refseq_name": "SH3 domain-binding glutamic acid-rich protein", "refseq_ac": "NP_056640", "gene_names_uniprotkb": "Sh3bgr", "gene_names_refseq": "5430437A18Rik; Sh3bgr", "protein_names_uniprotkb": "SH3 domain-binding glutamic acid-rich protein; SH3BGR protein", "protein_names_refseq": "SH3 domain-binding glutamic acid-rich protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:50795)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;35820727;36288343;37507081;39927985", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WUZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64327-1", "uniprot_id": "MEA1_MOUSE", "mass": 18584.0, "length": 174, "protein_name": "Male-enhanced antigen 1", "gene_name": "Mea1", "organism": "Mouse", "refseq_name": "male-enhanced antigen 1 isoform a", "refseq_ac": "NP_001264238", "gene_names_uniprotkb": "Mea1; Mea", "gene_names_refseq": "Mea-1; Mea1", "protein_names_uniprotkb": "Male-enhanced antigen 1; MEA-1", "protein_names_refseq": "male-enhanced antigen 1 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:17256)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12444059;15051958;21183079;21750661;2813404;8268232", "class_list": "", "function": "A comparative expression study of Mea1 and the B56delta subunit of protein phosphatase 2A in spermatogenesis., [RefSeq, PubMed]; Localization of the male-enhanced antigen-1 suggests that it may function in the very late stages of spermiogenesis, [RefSeq, PubMed]; May play an important role in spermatogenesis and/or testis development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q793G4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64327-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C9J3-1", "uniprot_id": "SPEF2_MOUSE", "mass": 197972.0, "length": 1724, "protein_name": "Sperm flagella and cilia-associated protein 2", "gene_name": "Spef2", "organism": "Mouse", "refseq_name": "sperm flagellar protein 2 isoform 1", "refseq_ac": "NP_001291971", "gene_names_uniprotkb": "Spef2; Kpl2", "gene_names_refseq": "C230086A09Rik; Spef2", "protein_names_uniprotkb": "Sperm flagella and cilia-associated protein 2; Protein KPL2; Sperm flagellar protein 2", "protein_names_refseq": "sperm flagellar protein 2 isoform 1; sperm flagellar protein 2", "tax_id": 10090, "disease": "spermatogenic failure 43 (Disease Ontology:DOID:0111917); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:320277)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19889948;21715716;21750661;28619825;29339787;31942643;32704025", "class_list": "", "function": "Data indicate that SPEF2 is required for cilia function/motility; defect in SPEF2 results in primary ciliary dyskinesia. SPEF2 plays important role in spermatogenesis and sperm flagellum assembly. (base/AA sequence data submitted to GenBank), [RefSeq, PubMed]; Genetic interaction between central pair apparatus genes CFAP221, CFAP54, and SPEF2 in mouse models of primary ciliary dyskinesia. Publication Status: Online-Only, [RefSeq, PubMed]; Investigated the function of SPEF2 during spermatogenesis using a male germ cell-specific Spef2 knockout model. In addition to defects in sperm tail development, we observed a duplication of the basal body and failure in manchette migration resulting in an abnormal head shape., [RefSeq, PubMed]; Mutations in SPEF2 are associated with multiple morphological abnormalities of the sperm flagella and primary ciliary dyskinesia., [RefSeq, PubMed]; Required for correct axoneme development in spermatozoa (PubMed:21715716, PubMed:28619825). Important for normal development of the manchette and sperm head morphology (PubMed:28619825). Essential for male fertility (PubMed:21715716, PubMed:28619825, PubMed:31942643). Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis (PubMed:28619825). Plays a role in bone growth where it seems to be required for normal osteoblast differentiation (PubMed:29339787). Required for normal beat frequency of tracheal epithelial cilia and oviduct cilia (PubMed:31942643)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The crucial importance of SPEF2 in sperm differentiation and involvement of SPEF2 in structuring of the sperm tail., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RSG5;E0CYG3;G0Z098", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007283 spermatogenesis;GO:0048705 skeletal system morphogenesis;GO:0044458 motile cilium assembly;GO:0048854 brain morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C9J3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05769-1", "uniprot_id": "PGH2_MOUSE", "mass": 69013.0, "length": 604, "protein_name": "Prostaglandin G/H synthase 2", "gene_name": "Ptgs2", "organism": "Mouse", "refseq_name": "prostaglandin G/H synthase 2 precursor", "refseq_ac": "NP_035328", "gene_names_uniprotkb": "Ptgs2; Cox-2; Cox2; Pghs-b; Tis10", "gene_names_refseq": "COX2; Cox-2; PES-2; PGHS-2; PHS II; PHS-2; Pghs2; Ptgs2; TIS10; gripghs", "protein_names_uniprotkb": "Prostaglandin G/H synthase 2; 1.14.99.1; COX-2; Cyclooxygenase-2; Glucocorticoid-regulated inflammatory cyclooxygenase; Gripghs; Macrophage activation-associated marker protein P71/73; PES-2; PGH synthase 2; PGHS-2; PHS II; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; TIS10 protein", "protein_names_refseq": "PGH synthase 2; cyclooxygenase-2; glucocorticoid-regulated inflammatory cyclooxygenase; macrophage activation-associated marker protein P71/73; prostaglandin G/H synthase 2 precursor; prostaglandin G/H synthase 2; prostaglandin H2 synthase 2", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colitis (Disease Ontology:DOID:0060180); polycystic kidney disease (Disease Ontology:DOID:0080322); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Parkinsonism (Disease Ontology:DOID:0080855); pleurisy (Disease Ontology:DOID:10247); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); meconium aspiration syndrome (Disease Ontology:DOID:11049); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); sarcoidosis (Disease Ontology:DOID:11335); nephrotic syndrome (Disease Ontology:DOID:1184); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); esophagitis (Disease Ontology:DOID:11963); secondary hyperparathyroidism (Disease Ontology:DOID:12466); Huntington's disease (Disease Ontology:DOID:12858); cardiovascular system disease (Disease Ontology:DOID:1287); lung cancer (Disease Ontology:DOID:1324); prostatitis (Disease Ontology:DOID:14654); cystic fibrosis (Disease Ontology:DOID:1485); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); Wernicke encephalopathy (Disease Ontology:DOID:2384); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); adenocarcinoma (Disease Ontology:DOID:299); granulosa cell tumor (Disease Ontology:DOID:2999); acute kidney failure (Disease Ontology:DOID:3021); glioblastoma (Disease Ontology:DOID:3068); gliosarcoma (Disease Ontology:DOID:3071); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); demyelinating disease (Disease Ontology:DOID:3213); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); gastritis (Disease Ontology:DOID:4029); systemic scleroderma (Disease Ontology:DOID:418); renal cell carcinoma (Disease Ontology:DOID:4450); avian influenza (Disease Ontology:DOID:4492); retrograde amnesia (Disease Ontology:DOID:4543); esophagus adenocarcinoma (Disease Ontology:DOID:4914); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); prolactinoma (Disease Ontology:DOID:5394); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); growth hormone secreting pituitary adenoma (Disease Ontology:DOID:6255); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); intestinal obstruction (Disease Ontology:DOID:8437); ulcerative colitis (Disease Ontology:DOID:8577); prostate carcinoma in situ (Disease Ontology:DOID:8634); in situ carcinoma (Disease Ontology:DOID:8719); Crohn's disease (Disease Ontology:DOID:8778); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); Barrett's esophagus (Disease Ontology:DOID:9206); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); pulmonary emphysema (Disease Ontology:DOID:9675); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:19225); (R-MMU-2142770); (R-MMU-2162123); (R-MMU-9018677); (R-MMU-9018679); (R-MMU-9025094); (R-MMU-9027604)", "pathway_count": 7, "publication_count": 34, "publication_id_list": "10.1101/2023.09.13.557529;10811226;10966456;11258925;12244105;12925531;1339449;1419907;1594589;1712772;1744122;20463020;20484733;20810665;21467029;21489986;21750661;22465430;22942274;24605250;25428506;25428507;27802388;29662056;30084848;31219806;31599954;34428180;37828378;39511505;8349699;8482922;8967954;9545330", "class_list": "", "function": "Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response (PubMed:12925531, PubMed:20463020, PubMed:20810665, PubMed:21489986, PubMed:22942274). The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:12925531, PubMed:20463020, PubMed:20810665, PubMed:21489986, PubMed:22942274). Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins (By similarity). In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids (By similarity). Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response (By similarity). Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols (By similarity). Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further metabolized by ALOX5 and LTA4H to generate 18S-RvE1 and 18S-RvE2. In vascular endothelial cells, converts docosapentaenoate (DPA, C22:5(n-3)) to 13R-HDPA, a precursor for 13-series resolvins (RvTs) shown to activate macrophage phagocytosis during bacterial infection (By similarity). In activated leukocytes, contributes to oxygenation of hydroxyeicosatetraenoates (HETE) to diHETES (5,15-diHETE and 5,11-diHETE) (By similarity). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products (By similarity). During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs) 15R-lipoxin A4 that regulates phagocytic microglia (PubMed:29662056)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The role of COX2 deficiency attenuates cardiac damage in acute myocardial infarction. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an enzyme that is a member of the prostaglandin G/H synthase family. The encoded protein converts arachidonic acid to prostaglandin endoperoxide H2 which is a key enzymatic step in prostaglandin biosynthesis. This gene is the inducible prostaglandin G/H synthase family member that is upregulated during inflammation. Aberrant regulation of this gene is associated with cancer progression in several tissues and an increased risk of cardiovascular events. This gene is the target of many non-steroidal anti-inflammatory drugs. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 1341, "biomarker_type": "", "glycan_count": 13, "disease_count": 76, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q543K3", "ec_number_list": "5.3.99.4;4.2.1.152;1.14.99.1;5.3.99.5", "go_molecular_function": "GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0004666 prostaglandin-endoperoxide synthase activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0001525 angiogenesis;GO:0006979 response to oxidative stress;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "Q05769-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06869-1", "uniprot_id": "UROK_MOUSE", "mass": 48268.0, "length": 433, "protein_name": "Urokinase-type plasminogen activator", "gene_name": "Plau", "organism": "Mouse", "refseq_name": "urokinase-type plasminogen activator precursor", "refseq_ac": "NP_032899", "gene_names_uniprotkb": "Plau", "gene_names_refseq": "Plau; u-PA; uPA", "protein_names_uniprotkb": "Urokinase-type plasminogen activator; 3.4.21.73; U-plasminogen activator; uPA", "protein_names_refseq": "U-plasminogen activator; urokinase-type plasminogen activator precursor; urokinase-type plasminogen activator", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); thrombosis (Disease Ontology:DOID:0060903); Alzheimer's disease 1 (Disease Ontology:DOID:0080348); urolithiasis (Disease Ontology:DOID:0080653); Quebec platelet disorder (Disease Ontology:DOID:0111050); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); hepatitis B (Disease Ontology:DOID:2043); transient cerebral ischemia (Disease Ontology:DOID:224); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); pleural empyema (Disease Ontology:DOID:3798); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); renal cell carcinoma (Disease Ontology:DOID:4450); brain edema (Disease Ontology:DOID:4724); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); peritonitis (Disease Ontology:DOID:8283); appendicitis (Disease Ontology:DOID:8337); steatotic liver disease (Disease Ontology:DOID:9452); meningitis (Disease Ontology:DOID:9471); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (mmu:18792); (R-MMU-6798695); (R-MMU-75205)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "20133942;21750661;26495903;2831940;28611361;2985383;30707839;34428180;37828378;38113659;38780522;8650190", "class_list": "", "function": "Decreased fertility in female mice lacking urokinase plasminogen activator., [RefSeq, PubMed]; Serine protease that cleaves the inactive precursor plasminogen at a specific Arg-Val peptide bond, converting it into active plasmin (PubMed:28611361, PubMed:30707839). Secreted as an inactive zymogen, it is recruited and activated at the cell surface through interaction with the urokinase plasminogen activator receptor (uPAR). Cell-surface activation enables localized, plasmin-dependent pericellular proteolysis, regulating extracellular matrix degradation in cell migration and tissue remodeling (By similarity). Also contributes to fibrinolysis and blood clot clearance by promoting plasmin generation (PubMed:8650190)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The Light Chain Allosterically Enhances the Protease Activity of Murine Urokinase-Type Plasminogen Activator., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 36, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;7.6.2.1;3.1.3.48;1.14.19.17;5.2.1.-;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;2.7.11.1;1.14.14.18;3.4.21.73;3.6.5.2;1.1.1.-;3.2.1.20;3.4.24.-;2.3.1.78;1.6.3.-;3.2.2.6;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;2.3.1.51;3.1.4.4;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:1905370 serine-type endopeptidase complex;GO:0097180 serine protease inhibitor complex", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0043403 skeletal muscle tissue regeneration;GO:2000345 regulation of hepatocyte proliferation;GO:0038195 urokinase plasminogen activator signaling pathway;GO:2000097 regulation of smooth muscle cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P06869-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925S4-1", "uniprot_id": "IL24_MOUSE", "mass": 25168.0, "length": 220, "protein_name": "Interleukin-24", "gene_name": "Il24", "organism": "Mouse", "refseq_name": "interleukin-24 precursor", "refseq_ac": "NP_444325", "gene_names_uniprotkb": "Il24; Mda7", "gene_names_refseq": "FISP; If2e; Il24; Mda-7; Mda7; St16", "protein_names_uniprotkb": "Interleukin-24; IL-24; IL-4-induced secreted protein; MDA-7; Melanoma differentiation-associated gene 7 protein; Th2-specific cytokine FISP", "protein_names_refseq": "IL-24; IL-4-induced secreted protein; interferon 2e; interleukin-24 precursor; melanoma differentiation-associated gene 7 protein; th2-specific cytokine FISP", "tax_id": 10090, "disease": "periodontal disease (Disease Ontology:DOID:3388)", "pathway": " (mmu:93672); (R-MMU-8854691)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11342597;15326486;18483274;18708357;21750661;31907348;35148201;38056582", "class_list": "", "function": "Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24, [RefSeq, PubMed]; Immune regulatory cytokine., [UniProtKB, UniProtKB]; Induction of Il24 by oncogenes may support tumor growth at the early stages of cancer, [RefSeq, PubMed]; May negatively regulate isoform 1 activity by causing its retention in the endoplasmic reticulum and increasing isoform 1 degradation by the ubiquitin proteasome pathway., [UniProtKB, PubMed]; Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Spinal interleukin-24 contributes to neuropathic pain after peripheral nerve injury through interleukin-20 receptor2 in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3QQZ3;Q925J3", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0043235 receptor complex", "go_biological_process": "GO:0006955 immune response;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q925S4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D142-1", "uniprot_id": "NUD14_MOUSE", "mass": 24444.0, "length": 222, "protein_name": "Uridine diphosphate glucose pyrophosphatase NUDT14", "gene_name": "Nudt14", "organism": "Mouse", "refseq_name": "uridine diphosphate glucose pyrophosphatase NUDT14 isoform 2", "refseq_ac": "NP_001303653", "gene_names_uniprotkb": "Nudt14", "gene_names_refseq": "1110030M18Rik; Nudt14; UGPPase", "protein_names_uniprotkb": "Uridine diphosphate glucose pyrophosphatase NUDT14; 3.6.1.-; 3.6.1.13; Nucleoside diphosphate-linked moiety X motif 14; Nudix motif 14; UDPG pyrophosphatase; UGPPase", "protein_names_refseq": "UDPG pyrophosphatase; nucleoside diphosphate-linked moiety X motif 14; nudix (nucleoside diphosphate linked moiety X)-type motif 14; nudix motif 14; uridine diphosphate glucose pyrophosphatase NUDT14 isoform 2; uridine diphosphate glucose pyrophosphatase NUDT14", "tax_id": 10090, "disease": "", "pathway": " (mmu:66174); (R-MMU-480985)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19896456;21750661", "class_list": "", "function": "Cytosolic pyrophosphatase hydrolyzing the diphosphate bond in various nucleotide-sugars with a higher efficiency for UDP-alpha-D-glucose and ADP-D-ribose., [UniProtKB, PubMed]; Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose., [UniProtKB, UniProtKB]; Nudt14 catalyzed the conversion of [beta-32P]UDP-glucose to [32P]glucose-1-P and UMP, confirming that it hydrolyzed the pyrophosphate of the nucleoside diphosphate sugar to generate glucose-1-P and UMP., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSD2", "ec_number_list": "3.6.1.13;3.6.1.16;3.6.1.53;3.6.1.-;3.6.1.45;3.6.1.58;2.7.7.96", "go_molecular_function": "GO:0008768 UDP-sugar diphosphatase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0047631 ADP-ribose diphosphatase activity;GO:0080042 ADP-glucose pyrophosphohydrolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0019693 ribose phosphate metabolic process;GO:0006753 nucleoside phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D142-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHI3-1", "uniprot_id": "OFUT2_MOUSE", "mass": 49429.0, "length": 429, "protein_name": "GDP-fucose protein O-fucosyltransferase 2", "gene_name": "Pofut2", "organism": "Mouse", "refseq_name": "GDP-fucose protein O-fucosyltransferase 2 precursor", "refseq_ac": "NP_084538", "gene_names_uniprotkb": "Pofut2", "gene_names_refseq": "2310011G23Rik; C21orf80; FUT13; Pofut2", "protein_names_uniprotkb": "GDP-fucose protein O-fucosyltransferase 2; 2.4.1.221; O-FucT-2; Peptide-O-fucosyltransferase 2", "protein_names_refseq": "GDP-fucose protein O-fucosyltransferase 2 precursor; GDP-fucose protein O-fucosyltransferase 2; O-FucT-2; peptide-O-fucosyltransferase 2", "tax_id": 10090, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:80294); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;20173027;20637190;21750661;31219806;34428180", "class_list": "glycogene;glycosyltransferase", "function": "GDP-fucose protein O-fucosyltransferase involved in one of the two pathways responsible for protein O-linked fucosylation, a unique post-translational modification of cysteine-knotted proteins that regulates various biological functions. This pathway targets proteins with Thrombospondin type-1 (TSP1) repeats (TSR) in the endoplasmic reticulum. Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:20637190). O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (PubMed:20637190). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13 (By similarity). The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (PubMed:20637190)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8VEM2;Q9CV66", "ec_number_list": "3.4.24.-;2.4.1.221;2.4.1.-;3.4.24.87;3.4.24.82;3.4.24.14", "go_molecular_function": "GO:0046922 peptide-O-fucosyltransferase activity;GO:0008417 fucosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:1903334 positive regulation of protein folding;GO:0001707 mesoderm formation;GO:0010468 regulation of gene expression;GO:0036066 protein O-linked glycosylation via fucose", "synthesized_glycan_count": 158, "hit_score": 1.1, "record_id": "Q8VHI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVU5-1", "uniprot_id": "NUDT9_MOUSE", "mass": 38604.0, "length": 350, "protein_name": "ADP-ribose pyrophosphatase", "gene_name": "Nudt9", "organism": "Mouse", "refseq_name": "ADP-ribose pyrophosphatase", "refseq_ac": "NP_083070", "gene_names_uniprotkb": "Nudt9", "gene_names_refseq": "1190002C07Rik; ADPR-PPase; Nudt9", "protein_names_uniprotkb": "ADP-ribose pyrophosphatase; 3.6.1.13; ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ADPR-PPase; Adenosine diphosphoribose pyrophosphatase; Nucleoside diphosphate-linked moiety X motif 9; Nudix motif 9", "protein_names_refseq": "ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ADP-ribose pyrophosphatase, mitochondrial; ADP-ribose pyrophosphatase; adenosine diphosphoribose pyrophosphatase; nucleoside diphosphate-linked moiety X motif 9; nudix (nucleoside diphosphate linked moiety X)-type motif 9; nudix motif 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:74167); (R-MMU-2393930)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16860484;21750661;37507081;37828378", "class_list": "", "function": "ADP-ribose hydrolysis is catalysed by NDP-sugar/alcohol pyrophosphatases of differing specificity, including a highly specific, low-K(m) ADP-ribose pyrophosphatase., [RefSeq, PubMed]; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. Has also a weak phosphohydrolase activity against NADH and FAD (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AH31;Q3TZ68;Q8K1J4", "ec_number_list": "3.6.1.13;3.6.1.16;3.6.1.53;3.6.1.-;3.6.1.45;3.6.1.58;2.7.7.96", "go_molecular_function": "GO:0047631 ADP-ribose diphosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0030054 cell junction;GO:0031965 nuclear membrane", "go_biological_process": "GO:0046032 ADP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BVU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKH7-1", "uniprot_id": "SIN1_MOUSE", "mass": 59009.0, "length": 522, "protein_name": "Target of rapamycin complex 2 subunit MAPKAP1", "gene_name": "Mapkap1", "organism": "Mouse", "refseq_name": "target of rapamycin complex 2 subunit MAPKAP1 isoform a", "refseq_ac": "NP_001277554", "gene_names_uniprotkb": "Mapkap1; Mip1; Sin1", "gene_names_refseq": "D230039K05Rik; Mapkap1; Sin1", "protein_names_uniprotkb": "Target of rapamycin complex 2 subunit MAPKAP1; Mitogen-activated protein kinase 2-associated protein 1; SAPK-interacting protein 1; Stress-activated map kinase-interacting protein 1; TORC2 subunit MAPKAP1", "protein_names_refseq": "SAPK-interacting protein 1; TORC2 subunit MAPKAP1; mitogen-activated protein kinase 2-associated protein 1; stress-activated map kinase-interacting protein 1; target of rapamycin complex 2 subunit MAPKAP1 isoform a; target of rapamycin complex 2 subunit MAPKAP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:227743); (R-MMU-1257604); (R-MMU-389357); (R-MMU-5218920); (R-MMU-6804757); (R-MMU-9856530)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "16962653;17054722;21750661;21757730;23142081;23388827;23684622;24161930;25738366;26235620;28143890;30571167;30837283;33850054;34713362;36748222", "class_list": "", "function": "Ang II Controls the Expression of Mapkap1 by miR-375 and Affects the Function of Islet beta Cells., [RefSeq, PubMed]; Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:16962653, PubMed:21757730, PubMed:24161930, PubMed:30837283, PubMed:33850054). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (By similarity). In contrast to mTORC1, mTORC2 is nutrient-insensitive (By similarity). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (PubMed:33850054). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:33850054). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:21757730, PubMed:30837283). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (PubMed:23142081, PubMed:23388827). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (By similarity). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (By similarity). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (By similarity). Inhibits HRAS and KRAS independently of mTORC2 complex (By similarity). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (By similarity). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MicroRNA-7a inhibits Isl1 expression to regulate insulin secretion by targeting Raf1 and Mapkap1 in NIT-1 cells., [RefSeq, PubMed]; Results reveal that the SIN1-rictor-mTOR function in Akt-Ser473 phosphorylation is required for TORC2 function in cell survival but is dispensable for TORC1 function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AN72;A2AN74;A2AR13;A2AR16;Q80UY4;Q8BMV5;Q8R2N9", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004674 protein serine/threonine kinase activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0046580 negative regulation of Ras protein signal transduction;GO:0030307 positive regulation of cell growth;GO:0032869 cellular response to insulin stimulus;GO:0033138 positive regulation of peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BKH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZU9-1", "uniprot_id": "NMD3B_MOUSE", "mass": 109158.0, "length": 1003, "protein_name": "Glutamate receptor ionotropic, NMDA 3B", "gene_name": "Grin3b", "organism": "Mouse", "refseq_name": "glutamate receptor ionotropic, NMDA 3B precursor", "refseq_ac": "NP_569722", "gene_names_uniprotkb": "Grin3b", "gene_names_refseq": "GluN3B; Grin3b; NR3B", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 3B; GluN3B; N-methyl-D-aspartate receptor subunit NR3B; NMDA receptor 4; NMDAR3B; NR3B; Nr4", "protein_names_refseq": "N-methyl-D-aspartate receptor subunit NR3B; NMDA receptor 4; NMDAR3B; glutamate [NMDA] receptor subunit 3B; glutamate receptor ionotropic, NMDA 3B precursor; glutamate receptor ionotropic, NMDA 3B; nr4", "tax_id": 10090, "disease": "", "pathway": " (mmu:170483)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11717388;11735224;11823786;12008020;14602821;21750661;25428506;34428180", "class_list": "", "function": "Assembling NMDA receptor subunit NR1 with NR3A or NR3B forms glycine-gated cation channels., [RefSeq, PubMed]; Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+). Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits. Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits. GluN3B subunit also binds D-serine and, in the absence of glycine, activates glycinergic receptor complexes, but with lower efficacy than glycine. Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; NR3B may modulate the function of NMDA receptors in somatic motor neurons during adulthood by controlling membrane trafficking and by reducing Ca2+ permeability, [RefSeq, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9393, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHV0", "ec_number_list": "1.8.-.-;2.7.11.1", "go_molecular_function": "GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0030594 neurotransmitter receptor activity;GO:0005261 monoatomic cation channel activity;GO:0016594 glycine binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0017146 NMDA selective glutamate receptor complex;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0035249 synaptic transmission, glutamatergic;GO:0048167 regulation of synaptic plasticity;GO:0051924 regulation of calcium ion transport;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q91ZU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3URD3-1", "uniprot_id": "SLMAP_MOUSE", "mass": 96933.0, "length": 845, "protein_name": "Sarcolemmal membrane-associated protein", "gene_name": "Slmap", "organism": "Mouse", "refseq_name": "sarcolemmal membrane-associated protein isoform 1", "refseq_ac": "NP_001297374", "gene_names_uniprotkb": "Slmap; Kiaa1601; Slap", "gene_names_refseq": "D330001L02Rik; Miranda; Slap; Slmap; mKIAA1601", "protein_names_uniprotkb": "Sarcolemmal membrane-associated protein; Sarcolemmal-associated protein", "protein_names_refseq": "sarcolemmal membrane-associated protein isoform 1; sarcolemmal membrane-associated protein; sarcolemmal-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:83997)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10986292;15086317;15126628;15591093;21750661;30084848;31219806;31599954;34418053;34428180;36288343;37507081;39366759;39417621", "class_list": "", "function": "Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex. The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (By similarity). May play a role during myoblast fusion (PubMed:15591093)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; SLMAP3 is crucial for organogenesis through mechanisms involving primary cilia formation., [RefSeq, PubMed]; SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLP0;Q3UIZ6;Q6ZPL8;Q8VC86;Q9EQ03", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential;GO:0072659 protein localization to plasma membrane;GO:0035329 hippo signaling;GO:0035331 negative regulation of hippo signaling;GO:1902305 regulation of sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q3URD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0PMG2-1", "uniprot_id": "MDGA1_MOUSE", "mass": 106047.0, "length": 956, "protein_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1", "gene_name": "Mdga1", "organism": "Mouse", "refseq_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform 1 precursor", "refseq_ac": "NP_001355352", "gene_names_uniprotkb": "Mdga1", "gene_names_refseq": "1200011I03Rik; GPIM; Mamdc3; Mdga1", "protein_names_uniprotkb": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1", "protein_names_refseq": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1 isoform 1 precursor; MAM domain-containing glycosylphosphatidylinositol anchor protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74762); (R-MMU-163125)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16641224;16959869;21750661;23248271;30899004;31908000;33300544;35074912", "class_list": "", "function": "MDGA1 negatively regulates amyloid precursor protein-mediated synapse inhibition in the hippocampus. Erratum:[Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2410758121. doi: 10.1073/pnas.2410758121. PMID: 38900803], [RefSeq, PubMed]; Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1., [RefSeq, PubMed]; Required for radial migration of cortical neurons in the superficial layer of the neocortex. Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; These findings show that MDGA1 is a unique marker for studies of cortical lamination and area patterning and together with recent reports suggest that MDGA1 has critical functions in forebrain/midbrain development., [RefSeq, PubMed]; We conclude that MDGA1 acts cell autonomously to control the migration of MDGA1-expressing superficial layer cortical neurons., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "E9PY95;E9QP80", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0099054 presynapse assembly;GO:0007399 nervous system development;GO:0001764 neuron migration;GO:0060134 prepulse inhibition", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q0PMG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WJ7-1", "uniprot_id": "SPS2L_MOUSE", "mass": 61669.0, "length": 558, "protein_name": "SPATS2-like protein", "gene_name": "Spats2l", "organism": "Mouse", "refseq_name": "SPATS2-like protein isoform 2", "refseq_ac": "NP_001158038", "gene_names_uniprotkb": "Spats2l", "gene_names_refseq": "2810022L02Rik; A230104H11Rik; Spats2l", "protein_names_uniprotkb": "SPATS2-like protein", "protein_names_refseq": "SPATS2-like protein isoform 2; SPATS2-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67198)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K322;Q8VC37", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91WJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R2B6-1", "uniprot_id": "SIA7D_MOUSE", "mass": 40773.0, "length": 360, "protein_name": "Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase", "gene_name": "St6galnac4", "organism": "Mouse", "refseq_name": "alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase", "refseq_ac": "NP_001263354", "gene_names_uniprotkb": "St6galnac4; Siat7d", "gene_names_refseq": "SIAT7-D; ST6GalNAcIV; Siat7d; St6galnac4", "protein_names_uniprotkb": "Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase; 2.4.3.7; NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase; SIAT7-D; ST6GalNAc IV; ST6GalNAcIV; Sialyltransferase 7D", "protein_names_refseq": "GalNAc alpha-2,6-sialyltransferase; ST6 neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; Sia-alpha-2-3-Gal-beta-1-3-GalNAc GalNAc-alpha-2,6-sialyltransferase; alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase; neuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2, 6-sialyltransferase; sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) D; sialyltransferase 7D", "tax_id": 10090, "disease": "", "pathway": " (mmu:20448); (R-MMU-4085001); (R-MMU-977068)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10207017;10601645;10731711;18299400;21750661;21952136;25428506;25605945;30084848;30779550;31219806;34428180;37386100", "class_list": "glycogene;glycosyltransferase", "function": "Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes. Publication Status: Online-Only, [RefSeq, PubMed]; Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains (PubMed:10207017, PubMed:10601645). Prefers O-glycans to glycoproteins or glycolipids (PubMed:10207017)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88725;Q9JHP0;Q9QUP9;Q9R2B5", "ec_number_list": "2.4.3.3;2.4.99.-;2.4.3.7", "go_molecular_function": "GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;GO:0047290 alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0009311 oligosaccharide metabolic process;GO:0001574 ganglioside biosynthetic process", "synthesized_glycan_count": 550, "hit_score": 1.7, "record_id": "Q9R2B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7XV04-1", "uniprot_id": "SKIT7_MOUSE", "mass": 45215.0, "length": 395, "protein_name": "Selection and upkeep of intraepithelial T-cells protein 7", "gene_name": "Skint7", "organism": "Mouse", "refseq_name": "selection and upkeep of intraepithelial T-cells protein 7 isoform 1 precursor", "refseq_ac": "NP_001136247", "gene_names_uniprotkb": "Skint7", "gene_names_refseq": "C130057D23Rik; Skint7", "protein_names_uniprotkb": "Selection and upkeep of intraepithelial T-cells protein 7; Skint-7", "protein_names_refseq": "novel immunoglobulin V-set and CD80-like C2-set immunoglobulin domain containing protein; selection and upkeep of intraepithelial T-cells protein 7 isoform 1 precursor; selection and upkeep of intraepithelial T-cells protein 7; skint 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:328505)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18408721;21750661", "class_list": "", "function": "May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A7TZF5;A7TZF6;A7TZF7;A7TZF8;E9Q3C9;M9MMJ4", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production;GO:0050863 regulation of T cell activation;GO:1903037 regulation of leukocyte cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A7XV04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02819-1", "uniprot_id": "NUCB1_MOUSE", "mass": 53409.0, "length": 459, "protein_name": "Nucleobindin-1", "gene_name": "Nucb1", "organism": "Mouse", "refseq_name": "nucleobindin-1 isoform 1 precursor", "refseq_ac": "NP_001157134", "gene_names_uniprotkb": "Nucb1; Nucb; Nuc", "gene_names_refseq": "B230337F23Rik; Calnuc; MTEST82; Nucb1; Nucb", "protein_names_uniprotkb": "Nucleobindin-1; CALNUC", "protein_names_refseq": "nucleobindin-1 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18220); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "11801660;12682304;1520323;15378723;16075062;17208939;17242355;18630941;19131326;19144319;21183079;21750661;22645316;23443134;26495903;26740625;29562282;34428180", "class_list": "", "function": "Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TU42;Q9CWA1;Q9D8J4;Q9DBL3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005509 calcium ion binding;GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:1903533 regulation of protein targeting", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q02819-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D083-1", "uniprot_id": "SPC24_MOUSE", "mass": 23416.0, "length": 201, "protein_name": "Kinetochore protein Spc24", "gene_name": "Spc24", "organism": "Mouse", "refseq_name": "kinetochore protein Spc24 isoform 1", "refseq_ac": "NP_080558", "gene_names_uniprotkb": "Spc24; Spbc24", "gene_names_refseq": "2410030K01Rik; Spbc24; Spc24", "protein_names_uniprotkb": "Kinetochore protein Spc24", "protein_names_refseq": "kinetochore protein Spc24 isoform 1; kinetochore protein Spc24; spindle pole body component 24 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67629); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "21750661;27713128;31219806;34428180;36210013", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Spc24 plays an important role in genomic stability maintenance during oocyte meiotic maturation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIF5;Q8CD13", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000776 kinetochore;GO:0000940 outer kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D083-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7XV14-1", "uniprot_id": "SKI11_MOUSE", "mass": 42262.0, "length": 364, "protein_name": "Selection and upkeep of intraepithelial T-cells protein 11", "gene_name": "Skint11", "organism": "Mouse", "refseq_name": "selection and upkeep of intraepithelial T-cells protein 11 isoform 1 precursor", "refseq_ac": "NP_001159499", "gene_names_uniprotkb": "Skint11", "gene_names_refseq": "A630098G03Rik; Gm569; Skint11", "protein_names_uniprotkb": "Selection and upkeep of intraepithelial T-cells protein 11; Skint-11", "protein_names_refseq": "selection and upkeep of intraepithelial T-cells protein 11 isoform 1 precursor; selection and upkeep of intraepithelial T-cells protein 11; skint 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:230623)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9652, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A7XV14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920D3-1", "uniprot_id": "MED28_MOUSE", "mass": 19538.0, "length": 178, "protein_name": "Mediator of RNA polymerase II transcription subunit 28", "gene_name": "Med28", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 28", "refseq_ac": "NP_080171", "gene_names_uniprotkb": "Med28; Fksg20", "gene_names_refseq": "1500003D12Rik; Eg1; FKSG20; Med28; magicin", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 28; Mediator complex subunit 28", "protein_names_refseq": "endothelial-derived; mediator of RNA polymerase II transcription subunit 28; mediator of RNA polymerase II transcription, subunit 28 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66999)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;26445504;30084848", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways (By similarity)., [UniProtKB]; These findings document the essential role of Med28 in the developing embryo as well as in acquisition and maintenance of pluripotency during reprogramming. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4G7;Q9CQF2", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0019827 stem cell population maintenance;GO:0051151 negative regulation of smooth muscle cell differentiation;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q920D3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70258-1", "uniprot_id": "SGCE_MOUSE", "mass": 49736.0, "length": 437, "protein_name": "Epsilon-sarcoglycan", "gene_name": "Sgce", "organism": "Mouse", "refseq_name": "epsilon-sarcoglycan isoform 1", "refseq_ac": "NP_001123660", "gene_names_uniprotkb": "Sgce", "gene_names_refseq": "Sgce; e-SG", "protein_names_uniprotkb": "Epsilon-sarcoglycan; Epsilon-SG", "protein_names_refseq": "epsilon-SG; epsilon-sarcoglycan isoform 1; epsilon-sarcoglycan", "tax_id": 10090, "disease": "myoclonic dystonia 11 (Disease Ontology:DOID:0090034); stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (mmu:20392); (R-MMU-9913351)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10488149;16099459;17200151;21750661;30899004;9405466", "class_list": "", "function": "Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sgce gene is imprinted, with exclusive expression from the paternal allele., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q921G2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0042383 sarcolemma", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O70258-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2V8-1", "uniprot_id": "S75A1_MOUSE", "mass": 49369.0, "length": 456, "protein_name": "Solute carrier family 75 member 1", "gene_name": "Mfsd10; Slc75a1", "organism": "Mouse", "refseq_name": "solute carrier family 75 member 1 isoform 1", "refseq_ac": "NP_080936", "gene_names_uniprotkb": "Mfsd10; Slc75a1; Mfsd10; Tetran", "gene_names_refseq": "0610009O03Rik; Mfsd10; Slc75a1; Tetran", "protein_names_uniprotkb": "Solute carrier family 75 member 1; Major facilitator superfamily domain-containing protein 10; Tetracycline transporter-like protein", "protein_names_refseq": "major facilitator superfamily domain containing 10; major facilitator superfamily domain-containing protein 10; solute carrier family 75 member 1 isoform 1; tetracycline transporter-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68294)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18638446;21750661;22820041;31142202;31906755", "class_list": "", "function": "Probable organic anion transporter which may serve as a transporter for some non-steroidal anti-inflammatory drugs (NSAIDs) as well as other organic anions across the luminal membranes of renal proximal tubules at the final excretion step into the urine., [UniProtKB, UniProtKB]; Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U800;Q3UN73;Q9D1A7", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0030659 cytoplasmic vesicle membrane;GO:0031526 brush border membrane;GO:0005637 nuclear inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0043252 sodium-independent organic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D2V8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLY1-1", "uniprot_id": "SMOC1_MOUSE", "mass": 51076.0, "length": 463, "protein_name": "SPARC-related modular calcium-binding protein 1", "gene_name": "Smoc1", "organism": "Mouse", "refseq_name": "SPARC-related modular calcium-binding protein 1 isoform 1 precursor", "refseq_ac": "NP_001139689", "gene_names_uniprotkb": "Smoc1; Srg", "gene_names_refseq": "2600002F22Rik; SRG; Smoc1", "protein_names_uniprotkb": "SPARC-related modular calcium-binding protein 1; SMOC-1; SPARC-related gene protein; Secreted modular calcium-binding protein 1", "protein_names_refseq": "SMOC-1; SPARC-related gene protein; SPARC-related modular calcium-binding protein 1 isoform 1 precursor; SPARC-related modular calcium-binding protein 1; SPARC-related protein; secreted modular calcium binding protein 1", "tax_id": 10090, "disease": "microphthalmia with limb anomalies (Disease Ontology:DOID:0060861)", "pathway": " (mmu:64075)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;16736127;21194678;21750661;21750680;25428506;30084848", "class_list": "", "function": "Expression of SMOC-1 examined in the early embryo day 7, as well as in following embryonic stages on days 12, 14, 16 & 18; broad and organ-specific distribution suggests multifunctional roles of SMOC-1 during mouse embryogenesis, [RefSeq, PubMed]; Probable regulator of osteoblast differentiation. Plays essential roles in both eye and limb development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9WVN9", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005604 basement membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0030198 extracellular matrix organization;GO:0010811 positive regulation of cell-substrate adhesion;GO:0060173 limb development;GO:0045667 regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BLY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K480-1", "uniprot_id": "MFRP_MOUSE", "mass": 63669.0, "length": 584, "protein_name": "Membrane frizzled-related protein", "gene_name": "Mfrp", "organism": "Mouse", "refseq_name": "complement C1q tumor necrosis factor-related protein 5 precursor", "refseq_ac": "NP_001177242", "gene_names_uniprotkb": "Mfrp", "gene_names_refseq": "Adie; C1qtnf5; Ctrp5; Mfrp", "protein_names_uniprotkb": "Membrane frizzled-related protein; Membrane-type frizzled-related protein", "protein_names_refseq": "Membrane frizzled-related protein; adiponectin e; complement C1q tumor necrosis factor-related protein 5 precursor; complement C1q tumor necrosis factor-related protein 5", "tax_id": 10090, "disease": "isolated microphthalmia 5 (Disease Ontology:DOID:0060837); nanophthalmos (Disease Ontology:DOID:0080634); retinitis pigmentosa (Disease Ontology:DOID:10584); microphthalmia (Disease Ontology:DOID:10629); fundus albipunctatus (Disease Ontology:DOID:11105); hyperopia (Disease Ontology:DOID:9834)", "pathway": " (mmu:259172)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12140190;16600989;17122142;17122143;21750661;38246238", "class_list": "", "function": "C1QTNF5 is a novel attachment factor that facilitates the entry of influenza A virus., [RefSeq, PubMed]; CTRP5, a secretory and membrane-associated protein, is localized to the lateral and apical membranes of the RPE and CB. Impaired secretion of the mutant protein may underlie the pathophysiology of long anterior zonules and late-onset retinal degeneration., [RefSeq, PubMed]; L-ORMD is due to insufficient levels of secreted C1QTNF5, compromised RPE cell function resulting from ER retention of the mutant protein or both mechanisms., [RefSeq, PubMed]; May play a role in eye development., [UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the C1q/tumor necrosis factor superfamily. This family member is a secretory protein that functions in eye development. Mutations in this gene are thought to underlie the pathophysiology of late-onset retinal degeneration (L-ORD) and early-onset long anterior zonules (LAZ). Bicistronic transcripts composed of the coding sequences for this gene (C1qtnf5) and the membrane-type frizzled-related protein gene (Mfrp) have been identified, and the resulting products can interact with each other. Co-transcription of C1qtnf5 and Mfrp has been observed in both human and mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPP4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007601 visual perception;GO:0060041 retina development in camera-type eye;GO:0042462 eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K480-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBD0-1", "uniprot_id": "ICA_MOUSE", "mass": 76766.0, "length": 700, "protein_name": "Inhibitor of carbonic anhydrase", "gene_name": "Inhca", "organism": "Mouse", "refseq_name": "inhibitor of carbonic anhydrase precursor", "refseq_ac": "NP_082194", "gene_names_uniprotkb": "Inhca; 1300017J02Rik; Ica", "gene_names_refseq": "1300017J02Rik; Ica; Inhca; mICA", "protein_names_uniprotkb": "Inhibitor of carbonic anhydrase", "protein_names_refseq": "inhibitor of carbonic anhydrase precursor", "tax_id": 10090, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)", "pathway": " (mmu:71775)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17330941;17511619;18712936;20571061;20572014;21750661;26495903;26740625;34428180;37507081", "class_list": "", "function": "Inhibitor for carbonic anhydrase 2 (CA2) (By similarity). Does not bind iron ions (PubMed:17511619, PubMed:18712936)., [UniProtKB, PubMed, PubMed, UniProtKB]; Murine inhibitor of carbonic anhydrase was a glycoprotein that associated with carbonic anhydrase in a 1:1 stoichiometry.[ICA], [RefSeq, PubMed]; This gene is a member of the transferrin gene family. Unlike many members of that gene family it does not play a significant role in iron homeostasis but rather is an inhibitor of carbonic anhydrase. This gene arose as a tandem duplicate of the adjacent transferrin gene sometime after the divergence of monotremes and therian mammals but before the diversification of placental mammals. This gene subsequently became a pseudogene in monkeys and apes. In lemurs and other strepsirrhine primates it possibly remains a protein coding gene. [provided by RefSeq, Oct 2021]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0005576 extracellular region", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9DBD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39098-1", "uniprot_id": "MA1A2_MOUSE", "mass": 72871.0, "length": 641, "protein_name": "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB", "gene_name": "Man1a2", "organism": "Mouse", "refseq_name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase IB", "refseq_ac": "NP_034893", "gene_names_uniprotkb": "Man1a2; Man1b", "gene_names_refseq": "Man1a2; Man1b; PCR2", "protein_names_uniprotkb": "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; 3.2.1.113; Alpha-1,2-mannosidase IB; Mannosidase alpha class 1A member 2; Processing alpha-1,2-mannosidase IB", "protein_names_refseq": "alpha-1,2-mannosidase IB; mannosidase 1, beta; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; processing alpha-1,2-mannosidase IB", "tax_id": 10090, "disease": "", "pathway": " (mmu:17156); (R-MMU-964827)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;30084848;34428180;8144579;9143489", "class_list": "glycogene;glycosylhydrolase", "function": "Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SUY6;Q5SUY7;Q60599;Q9CUY9", "ec_number_list": "3.2.1.113;3.2.1.-", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0048286 lung alveolus development;GO:0005975 carbohydrate metabolic process;GO:0007585 respiratory gaseous exchange by respiratory system;GO:0036503 ERAD pathway;GO:0009100 glycoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P39098-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6JPI3-1", "uniprot_id": "MD13L_MOUSE", "mass": 241758.0, "length": 2207, "protein_name": "Mediator of RNA polymerase II transcription subunit 13-like", "gene_name": "Med13l", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 13-like isoform 2", "refseq_ac": "NP_766012", "gene_names_uniprotkb": "Med13l; Kiaa1025; Thrap2; Trap240l", "gene_names_refseq": "2210413I17Rik; 6330591G05Rik; 9030618F05Rik; Med13l; Thrap2; Trap240L; mKIAA1025", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 13-like; Mediator complex subunit 13-like; Thyroid hormone receptor-associated protein 2; Thyroid hormone receptor-associated protein complex 240 kDa component-like", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 13-like isoform 2; mediator of RNA polymerase II transcription subunit 13-like; thyroid hormone receptor associated protein 2; thyroid hormone receptor-associated protein complex 240 kDa component-like", "tax_id": 10090, "disease": "dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:76199)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15145061;21750661;31219806;34428180;36798993", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MED13L and its disease-associated variants influence the dendritic development of cerebral cortical neurons in the mammalian brain., [RefSeq, PubMed]; Transcripts were most abundant in heart., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRF4;Q3UQI8;Q80TM3;Q80WQ0", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016592 mediator complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6JPI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04886-1", "uniprot_id": "SOX8_MOUSE", "mass": 49879.0, "length": 464, "protein_name": "Transcription factor SOX-8", "gene_name": "Sox8", "organism": "Mouse", "refseq_name": "transcription factor SOX-8", "refseq_ac": "NP_035577", "gene_names_uniprotkb": "Sox8; Sox-8", "gene_names_refseq": "Sox8", "protein_names_uniprotkb": "Transcription factor SOX-8", "protein_names_refseq": "SRY-box containing gene 8; transcription factor SOX-8", "tax_id": 10090, "disease": "", "pathway": " (mmu:20681)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10684944;21750661;39201442;8441686", "class_list": "", "function": "Transcription Factors Sox8 and Sox10 Contribute with Different Importance to the Maintenance of Mature Oligodendrocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0046533 negative regulation of photoreceptor cell differentiation;GO:0048484 enteric nervous system development;GO:0072289 metanephric nephron tubule formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q04886-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ABV5-1", "uniprot_id": "MED14_MOUSE", "mass": 160966.0, "length": 1459, "protein_name": "Mediator of RNA polymerase II transcription subunit 14", "gene_name": "Med14", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 14 isoform a", "refseq_ac": "NP_001041673", "gene_names_uniprotkb": "Med14; Crsp2; Gm641; Trap170", "gene_names_refseq": "9930001L01Rik; Crsp2; Gm641; Med14; ORF1; Trap170", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 14; CRSP complex subunit 2; Cofactor required for Sp1 transcriptional activation subunit 2; Mediator complex subunit 14; Thyroid hormone receptor-associated protein complex 170 kDa component; Trap170", "protein_names_refseq": "CRSP complex subunit 2; cofactor required for Sp1 transcriptional activation subunit 2 (150 kDa); cofactor required for Sp1 transcriptional activation, subunit 2; mediator of RNA polymerase II transcription subunit 14 isoform a; mediator of RNA polymerase II transcription subunit 14; thyroid hormone receptor-associated protein complex 170 kDa component", "tax_id": 10090, "disease": "", "pathway": " (mmu:26896)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10512684;17132730;21183079;21750661;25605945;30084848;30779550;31219806;34428180;40997131", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQU3;Q6P1H5;Q9R0T1;Q9WTN9", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A2ABV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AWL7-1", "uniprot_id": "MGAP_MOUSE", "mass": 328802.0, "length": 3003, "protein_name": "MAX gene-associated protein", "gene_name": "Mga", "organism": "Mouse", "refseq_name": "MAX gene-associated protein isoform 1", "refseq_ac": "NP_038748", "gene_names_uniprotkb": "Mga; Kiaa4252", "gene_names_refseq": "C130042M01Rik; D030062C11Rik; Mad5; Mga", "protein_names_uniprotkb": "MAX gene-associated protein", "protein_names_refseq": "MAX gene-associated protein isoform 1; MAX gene-associated protein; MAX-interacting protein; Max dimerization protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:29808); (R-MMU-8953750)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10601024;21750661;21952136;25605945;31219806;34203471;34428180;36180527;36852467;38454121;40997131", "class_list": "", "function": "Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia., [RefSeq, PubMed]; Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A2AWL6;Q3TS36;Q6A056;Q8BQX1;Q8CCL4;Q9QXJ5", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0071339 MLL1 complex;GO:0090571 RNA polymerase II transcription repressor complex", "go_biological_process": "GO:0001708 cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "A2AWL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41242-1", "uniprot_id": "MATK_MOUSE", "mass": 56056.0, "length": 505, "protein_name": "Megakaryocyte-associated tyrosine-protein kinase", "gene_name": "Matk", "organism": "Mouse", "refseq_name": "megakaryocyte-associated tyrosine-protein kinase isoform 3", "refseq_ac": "NP_001272783", "gene_names_uniprotkb": "Matk; Ctk; Ntk", "gene_names_refseq": "CHK; HYL; Matk; Ntk; p56ntk", "protein_names_uniprotkb": "Megakaryocyte-associated tyrosine-protein kinase; 2.7.10.2; Protein kinase NTK; Tyrosine-protein kinase CTK", "protein_names_refseq": "Csk homologous kinase; megakaryocyte-associated tyrosine-protein kinase isoform 3; megakaryocyte-associated tyrosine-protein kinase; protein kinase NTK; tyrosine protein kinase; tyrosine-protein kinase CTK", "tax_id": 10090, "disease": "", "pathway": " (mmu:17179); (R-MMU-8863795)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;29440352;7511815;7898936;7970703;8197166", "class_list": "", "function": "Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation., [UniProtKB]; Matk plays a critical role in bone metabolism by impairing the functions of osteoclasts and osteoblasts via distinct mechanisms involving inhibition of c-Src-dependent and -independent signaling pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LE90", "ec_number_list": "2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.40;2.7.11.23", "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:1902533 positive regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P41242-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VT8-1", "uniprot_id": "SIM14_MOUSE", "mass": 10732.0, "length": 99, "protein_name": "Small integral membrane protein 14", "gene_name": "Smim14", "organism": "Mouse", "refseq_name": "small integral membrane protein 14", "refseq_ac": "NP_598458", "gene_names_uniprotkb": "Smim14; 1110003E01Rik", "gene_names_refseq": "1110003E01Rik; 1700127H04Rik; 5430439C17Rik; MAd4; Smim14", "protein_names_uniprotkb": "Small integral membrane protein 14", "protein_names_refseq": "small integral membrane protein 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:68552)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;24499674", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91VT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZQH8-1", "uniprot_id": "NU188_MOUSE", "mass": 196696.0, "length": 1759, "protein_name": "Nucleoporin NUP188", "gene_name": "Nup188", "organism": "Mouse", "refseq_name": "nucleoporin NUP188 isoform 1", "refseq_ac": "NP_938046", "gene_names_uniprotkb": "Nup188; Kiaa0169", "gene_names_refseq": "Nup188", "protein_names_uniprotkb": "Nucleoporin NUP188", "protein_names_refseq": "nucleoporin NUP188 homolog; nucleoporin NUP188 isoform 1", "tax_id": 10090, "disease": "Sandestig-Stefanova syndrome (Disease Ontology:DOID:0081272); respiratory failure (Disease Ontology:DOID:11162)", "pathway": " (mmu:227699); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-9615933)", "pathway_count": 19, "publication_count": 20, "publication_id_list": "21183079;21606357;21750661;22517741;22645316;25428506;25605945;30059200;30084848;30779550;31219806;32782141;34428180;34887587;35820727;36210013;36852467;40021952;40885482;40997131", "class_list": "", "function": "Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Required for proper protein transport into the nucleus., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA15;Q80UL4;Q8C7A1;Q8R3F1", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0044611 nuclear pore inner ring", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0051028 mRNA transport;GO:0006405 RNA export from nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q6ZQH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3URS3-1", "uniprot_id": "LRCL1_MOUSE", "mass": 18181.0, "length": 161, "protein_name": "Leucine-rich colipase-like protein 1", "gene_name": "Lrcol1", "organism": "Mouse", "refseq_name": "leucine-rich colipase-like protein 1 precursor", "refseq_ac": "NP_001297638", "gene_names_uniprotkb": "Lrcol1; Clpsl3; Gm1679", "gene_names_refseq": "Clpsl3; Gm1679; Lrcol1", "protein_names_uniprotkb": "Leucine-rich colipase-like protein 1; Colipase-like protein 3", "protein_names_refseq": "colipase-like protein 3; leucine-rich colipase-like protein 1 precursor; leucine-rich colipase-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:381667)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJP8;H9C9P1", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3URS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CH62-1", "uniprot_id": "LTO1_MOUSE", "mass": 15221.0, "length": 137, "protein_name": "Protein LTO1 homolog", "gene_name": "LTO1; Lto1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LTO1; Lto1; Oraov1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein LTO1 homolog; Oral cancer-overexpressed protein 1 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:72284)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation. May play a role in the regulation of proline metabolism and ROS production., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91YY7;Q922P0;Q9D7Y4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0000723 telomere maintenance;GO:0006413 translational initiation;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CH62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70665-1", "uniprot_id": "SIAE_MOUSE", "mass": 60775.0, "length": 541, "protein_name": "Sialate O-acetylesterase", "gene_name": "Siae", "organism": "Mouse", "refseq_name": "sialate O-acetylesterase", "refseq_ac": "NP_035864", "gene_names_uniprotkb": "Siae; Ysg2", "gene_names_refseq": "LSE; Siae; Ysg2", "protein_names_uniprotkb": "Sialate O-acetylesterase; 3.1.1.53; SIAE; Sialic acid-specific 9-O-acetylesterase; Yolk sac protein 2", "protein_names_refseq": "clone 165; sialate O-acetylesterase; sialic acid-specific 9-O-acetylesterase; yolk sac gene 2; yolk sac protein 2", "tax_id": 10090, "disease": "autoimmune disease (Disease Ontology:DOID:417)", "pathway": " (mmu:22619)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10464298;19103880;21750661;23308225;26495903;30899004;31219806;36852467;8662838;8918804", "class_list": "glycogene", "function": "Catalyzes the removal of O-acetyl ester groups from position 9 of the free diacetylated sialate N-acetyl-9-O-acetylneuraminate (Neu5,9Ac2) in the cytosol and of the diacetylated sialate residues of sialylglycoconjugates in the lysosomes (Probable) (PubMed:8662838). Together with the sialate-O-acetyltransferase they regulate the balance of acetylated sialoglycoconjugates, key players in various processes such as cell-cell interactions, host-pathogen recognition, and tumor antigenicity (Probable)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Sialate:O-acetyl esterase is a catalytic regulator of B cell signaling and plays an essential role in the maintenance of immunological tolerance in the B lineage., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 35, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNZ5;Q544V7;Q61044;Q8C902;Q8CBM6;Q8CC41;Q8CEB7;Q922L0", "ec_number_list": "3.1.1.53", "go_molecular_function": "GO:0001681 sialate O-acetylesterase activity;GO:0106330 sialate 9-O-acetylesterase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0002682 regulation of immune system process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P70665-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBD2-1", "uniprot_id": "MARH8_MOUSE", "mass": 32243.0, "length": 286, "protein_name": "E3 ubiquitin-protein ligase MARCHF8", "gene_name": "Marchf8", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MARCHF8 isoform 1", "refseq_ac": "NP_001289312", "gene_names_uniprotkb": "Marchf8; March8; Mir", "gene_names_refseq": "1300017E09Rik; MARCH-VIII; March8; Marchf8; Mir", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF8; 2.3.2.27; Cellular modulator of immune recognition; MARCH-VIII; Membrane-associated RING finger protein 8; Membrane-associated RING-CH protein VIII; RING-type E3 ubiquitin transferase MARCHF8; c-MIR", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH8; E3 ubiquitin-protein ligase MARCHF8 isoform 1; E3 ubiquitin-protein ligase MARCHF8; RING-type E3 ubiquitin transferase MARCH8; RING-type E3 ubiquitin transferase MARCHF8; c-mir, cellular modulator of immune recognition; membrane-associated RING finger protein 8; membrane-associated RING-CH protein VIII; membrane-associated ring finger (C3HC4) 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:71779)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16785530;21750661;27503069;27503071;34285233;35503863;37747937", "class_list": "", "function": "CD83-mediated MHCII stabilization through antagonism of March8 as a novel functional adaptation of cortical epithelial cells for T cell selection., [RefSeq, PubMed]; E3 Ubiquitin Ligase MARCH8 Promotes Pancreatic Cancer Growth and Metastasis by Activating STAT3 via Degradation of PTPN4., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity (PubMed:16785530, PubMed:35503863). Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins. Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation. Mediates the regulation of constitutive ubiquitination and trafficking of the viral restriction factor BST2 within the endocytic pathway. Plays a role in maintenance of immune tolerance to self by promoting the turnover and proteasomal degradation of PD-L1/CD274 via ubiquitination. Catalyzes the 'Lys-63'-linked polyubiquitylation of cGAS thereby inhibiting its DNA binding ability and impairing its antiviral innate immunity (PubMed:35503863). Negatively regulates IL7-mediated T-cell homeostasis by mediating 'Lys-27'-linked polyubiquitination of IL7R, leading to its lysosomal degradation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes. Publication Status: Online-Only, [RefSeq, PubMed]; Orchestrated regulation of MHC II surface expression in thymic epithelial cells by MARCH 8 and CD83 plays a major role in CD4(+) T cell selection., [RefSeq, PubMed]; The protein encoded by this gene is a member of the membrane-associated really interesting new gene-CH family of proteins. These proteins are E3 ubiquitin-protein ligases that modulate antigen presentation by downregulating major histocompatibility complex class II surface expression through endocytosis. The transcript is primarily expressed by dendritic cells and macrophages. Overexpression of this gene in antigen presenting cells results in immune defective phenotypes, including resistance to autoimmune disease onset. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0042289 MHC class II protein binding;GO:0042287 MHC protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006955 immune response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0002250 adaptive immune response;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DBD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXL9-1", "uniprot_id": "IFFO1_MOUSE", "mass": 62415.0, "length": 562, "protein_name": "Non-homologous end joining factor IFFO1", "gene_name": "Iffo1", "organism": "Mouse", "refseq_name": "non-homologous end joining factor IFFO1 isoform a", "refseq_ac": "NP_001034758", "gene_names_uniprotkb": "Iffo1; Iffo", "gene_names_refseq": "4733401N06Rik; A930037G23Rik; HOM-TES-103; Iffo1; Iffo", "protein_names_uniprotkb": "Non-homologous end joining factor IFFO1; Intermediate filament family orphan 1; NHEJ factor IFFO1", "protein_names_refseq": "NHEJ factor IFFO1; non-homologous end joining factor IFFO1 isoform a; non-homologous end joining factor IFFO1", "tax_id": 10090, "disease": "", "pathway": " (mmu:320678)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22517741;22645316;25428506;30016717;30059200;31548606;32782141;40021952;40885482", "class_list": "", "function": "Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that will relocalize to the DSB sites in a XRCC4-dependent manner and promote the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQI1;Q6PFE6;Q8BXS3;Q8C1D6", "ec_number_list": "", "go_molecular_function": "GO:0008093 cytoskeletal anchor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005882 intermediate filament;GO:0016363 nuclear matrix;GO:0035861 site of double-strand break;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0006303 double-strand break repair via nonhomologous end joining;GO:1990683 DNA double-strand break attachment to nuclear envelope", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q8BXL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7XV07-1", "uniprot_id": "SKIT8_MOUSE", "mass": 45092.0, "length": 398, "protein_name": "Selection and upkeep of intraepithelial T-cells protein 8", "gene_name": "Skint8", "organism": "Mouse", "refseq_name": "selection and upkeep of intraepithelial T-cells protein 8 precursor", "refseq_ac": "NP_001093936", "gene_names_uniprotkb": "Skint8", "gene_names_refseq": "Skint8", "protein_names_uniprotkb": "Selection and upkeep of intraepithelial T-cells protein 8; Skint-8", "protein_names_refseq": "selection and upkeep of intraepithelial T-cells protein 8 precursor; selection and upkeep of intraepithelial T-cells protein 8; skint-8", "tax_id": 10090, "disease": "", "pathway": " (mmu:639774)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18408721;21750661", "class_list": "", "function": "May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A7TZF9;A7TZG0;A7XV10;E9QA97", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production;GO:0050863 regulation of T cell activation;GO:1903037 regulation of leukocyte cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A7XV07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35309-1", "uniprot_id": "NMI_MOUSE", "mass": 35236.0, "length": 314, "protein_name": "N-myc-interactor", "gene_name": "Nmi", "organism": "Mouse", "refseq_name": "N-myc-interactor isoform a", "refseq_ac": "NP_001135420", "gene_names_uniprotkb": "Nmi", "gene_names_refseq": "Nmi", "protein_names_uniprotkb": "N-myc-interactor; N-myc and STAT interactor; Nmi", "protein_names_refseq": "N-mcy (and STAT) interactor; N-myc-interactor isoform a; N-myc-interactor", "tax_id": 10090, "disease": "", "pathway": " (mmu:64685)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;23956435;29038465;29326438;33761305;34362845;35820727;37846815;39125716", "class_list": "", "function": "Acts as a signaling pathway regulator involved in innate immune system response (PubMed:23956435). In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis (By similarity). Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription (By similarity). In response to interferon IFN-alpha, associates in a complex with transcriptional regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 (By similarity). In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (By similarity). Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (PubMed:23956435). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion (By similarity). Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (By similarity)., [UniProtKB, UniProtKB, PubMed]; IFP35 family proteins promote neuroinflammation and multiple sclerosis., [RefSeq, PubMed]; N-Myc and STAT Interactor is an Endometriosis Suppressor. Publication Status: Online-Only, [RefSeq, PubMed]; NMI Facilitates Influenza A Virus Infection by Promoting Degradation of IRF7 through TRIM21., [RefSeq, PubMed]; NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis., [RefSeq, PubMed]; Nmi has a distinct role in the differentiation process of mammary luminal epithelial cell compartment and developmental aberrations resulting from Nmi absence contribute to metastasis., [RefSeq, PubMed]; These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99M49", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045087 innate immune response;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0009615 response to virus;GO:0050729 positive regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35309-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHU9-1", "uniprot_id": "INO1_MOUSE", "mass": 60932.0, "length": 557, "protein_name": "Inositol-3-phosphate synthase 1", "gene_name": "Isyna1", "organism": "Mouse", "refseq_name": "inositol-3-phosphate synthase 1", "refseq_ac": "NP_076116", "gene_names_uniprotkb": "Isyna1; Ino1", "gene_names_refseq": "1300017C10Rik; IPS 1; Isyna1", "protein_names_uniprotkb": "Inositol-3-phosphate synthase 1; 5.5.1.4; IPS 1; MI-1-P synthase; MIP synthase; Myo-inositol 1-phosphate synthase", "protein_names_refseq": "L-myo-inositol 1-phosphate isomerase; MI-1-P synthase; MIP synthase; inositol-3-phosphate synthase 1; similar to Homo sapiens myo-inositol-1-phosphate synthase encoded by GenBank Accession numbers AF220530, AF251265 and AF218361", "tax_id": 10090, "disease": "acquired metabolic disease (Disease Ontology:DOID:0060158); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (mmu:71780); (R-MMU-1855183)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;14613899;17121280;21750661;25428506;25605945;26495903;27802388;28011936;28935714;30084848;30779550;31219806;34428180;35820727;35984892;37828378", "class_list": "", "function": "Isyna1 is highly expressed in two types of germ cells, pachytene spermatocytes and round spermatids, [RefSeq, PubMed]; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9393, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.5.1.4", "go_molecular_function": "GO:0004512 inositol-3-phosphate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006021 inositol biosynthetic process;GO:0008654 phospholipid biosynthetic process;GO:1900089 negative regulation of inositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9JHU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AG50-1", "uniprot_id": "MA7D2_MOUSE", "mass": 86050.0, "length": 781, "protein_name": "MAP7 domain-containing protein 2", "gene_name": "Map7d2", "organism": "Mouse", "refseq_name": "MAP7 domain-containing protein 2 isoform 1", "refseq_ac": "NP_001074593", "gene_names_uniprotkb": "Map7d2; Mtap7d2", "gene_names_refseq": "1600028E09Rik; 2900002G04Rik; 5330432J06Rik; C030036K04Rik; Map7d2; Mtap7d2", "protein_names_uniprotkb": "MAP7 domain-containing protein 2", "protein_names_refseq": "MAP7 domain-containing protein 2 isoform 1; MAP7 domain-containing protein 2; novel E-MAP-115 family protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:78283)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16452087;21750661;22645316;35470240;40021952;40885482", "class_list": "", "function": "Microtubule-stabilizing protein involved in the control of cell motility and neurite outgrowth (PubMed:35470240). Acts as a critical cofactor for kinesin transport; in the proximal axon regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AG54;Q8BLE6;Q8BMQ4;Q9D2A4", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0019894 kinesin binding;GO:0140778 microtubule stabilizing activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule;GO:0030424 axon;GO:0015630 microtubule cytoskeleton;GO:0043005 neuron projection", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0061564 axon development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A2AG50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0X7-1", "uniprot_id": "SGPL1_MOUSE", "mass": 63677.0, "length": 568, "protein_name": "Sphingosine-1-phosphate lyase 1", "gene_name": "Sgpl1", "organism": "Mouse", "refseq_name": "sphingosine-1-phosphate lyase 1", "refseq_ac": "NP_001303602", "gene_names_uniprotkb": "Sgpl1; Spl", "gene_names_refseq": "D10Xrf456; S1PL; Sgpl1; Spl", "protein_names_uniprotkb": "Sphingosine-1-phosphate lyase 1; 4.1.2.27; S1PL; SP-lyase 1; SPL 1; Sphingosine-1-phosphate aldolase; mSPL", "protein_names_refseq": "SP-lyase 1; SPL 1; sphingosine-1-phosphate aldolase; sphingosine-1-phosphate lyase 1", "tax_id": 10090, "disease": "RENI syndrome (Disease Ontology:DOID:0080265); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); nephrotic syndrome (Disease Ontology:DOID:1184); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20397); (R-MMU-9845614)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "12584204;15522238;18250455;20097939;21173151;21750661;25428506;26495903;28011936;28165339;28165343;28262793;28521611;30084848;30779550;31599954;34428180;34887587;35886926;35973936;37453647;37828378;9464245", "class_list": "glycogene", "function": "Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (PubMed:20097939, PubMed:9464245). Elevates stress-induced ceramide production and apoptosis (PubMed:9464245). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts (PubMed:20097939, PubMed:28262793). Involved in the regulation of pro-inflammatory response and neutrophil trafficking (PubMed:21173151). Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (PubMed:28521611). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; SPL may be involved in the regulation of intracellular S1P levels during this differentiation, [RefSeq, PubMed]; Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Sphingosine-1-phosphate-lyase deficiency affects glucose metabolism in a way that abets oncogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 36, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54955;Q8C942", "ec_number_list": "4.1.2.27", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008117 sphinganine-1-phosphate aldolase activity;GO:0016829 lyase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0030149 sphingolipid catabolic process;GO:0001570 vasculogenesis;GO:0006631 fatty acid metabolic process;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8R0X7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99L48-1", "uniprot_id": "NMD3_MOUSE", "mass": 57611.0, "length": 503, "protein_name": "60S ribosomal export protein NMD3", "gene_name": "Nmd3", "organism": "Mouse", "refseq_name": "60S ribosomal export protein NMD3 isoform 1", "refseq_ac": "NP_598548", "gene_names_uniprotkb": "Nmd3", "gene_names_refseq": "Nmd3", "protein_names_uniprotkb": "60S ribosomal export protein NMD3", "protein_names_refseq": "60S ribosomal export protein NMD3 isoform 1; 60S ribosomal export protein NMD3; NMD3 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:97112)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21183079;21750661;25428506;25605945;30084848;30779550;34203471;34428180;34887587;35984892", "class_list": "", "function": "Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPR1;Q8BM61", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0015031 protein transport;GO:1902680 positive regulation of RNA biosynthetic process;GO:1904751 positive regulation of protein localization to nucleolus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99L48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UMG5-1", "uniprot_id": "LRCH2_MOUSE", "mass": 84989.0, "length": 773, "protein_name": "Leucine-rich repeat and calponin homology domain-containing protein 2", "gene_name": "Lrch2", "organism": "Mouse", "refseq_name": "leucine-rich repeat and calponin homology domain-containing protein 2 isoform 1", "refseq_ac": "NP_001074642", "gene_names_uniprotkb": "Lrch2; Kiaa1495", "gene_names_refseq": "Lrch2; mKIAA1495", "protein_names_uniprotkb": "Leucine-rich repeat and calponin homology domain-containing protein 2", "protein_names_refseq": "leucine-rich repeat and calponin homology domain-containing protein 2 isoform 1; leucine-rich repeat and calponin homology domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:210297)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May play a role in the organization of the cytoskeleton., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AMN8;Q7TNP9;Q80TC9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UMG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7XUY5-1", "uniprot_id": "SKIT5_MOUSE", "mass": 165918.0, "length": 1461, "protein_name": "Selection and upkeep of intraepithelial T-cells protein 5", "gene_name": "Skint5", "organism": "Mouse", "refseq_name": "selection and upkeep of intraepithelial T-cells protein 5 isoform 1 precursor", "refseq_ac": "NP_001161348", "gene_names_uniprotkb": "Skint5", "gene_names_refseq": "Skint-5; Skint5", "protein_names_uniprotkb": "Selection and upkeep of intraepithelial T-cells protein 5; Skint-5", "protein_names_refseq": "selection and upkeep of intraepithelial T-cells protein 5 isoform 1 precursor; selection and upkeep of intraepithelial T-cells protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:242627)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18408721;21750661;25428506", "class_list": "", "function": "May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7XUY9;A7XUZ2", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production;GO:0050863 regulation of T cell activation;GO:1903037 regulation of leukocyte cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A7XUY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NV83-1", "uniprot_id": "SR140_MOUSE", "mass": 118261.0, "length": 1029, "protein_name": "U2 snRNP-associated SURP motif-containing protein", "gene_name": "U2surp", "organism": "Mouse", "refseq_name": "U2 snRNP-associated SURP motif-containing protein isoform 1", "refseq_ac": "NP_001108449", "gene_names_uniprotkb": "U2surp; Sr140", "gene_names_refseq": "2610101N10Rik; Sr140; U2surp", "protein_names_uniprotkb": "U2 snRNP-associated SURP motif-containing protein; 140 kDa Ser/Arg-rich domain protein; U2-associated protein SR140", "protein_names_refseq": "140 kDa Ser/Arg-rich domain protein; U2 snRNP-associated SURP motif-containing protein isoform 1; U2 snRNP-associated SURP motif-containing protein; U2-associated protein SR140", "tax_id": 10090, "disease": "", "pathway": " (mmu:67958); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;34428180;34887587;35820727;39627609;40021952", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QK93;Q9CSW7;Q9CT00", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005686 U2 snRNP", "go_biological_process": "GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6NV83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35626-1", "uniprot_id": "RASD1_MOUSE", "mass": 31684.0, "length": 280, "protein_name": "Dexamethasone-induced Ras-related protein 1", "gene_name": "Rasd1", "organism": "Mouse", "refseq_name": "dexamethasone-induced Ras-related protein 1", "refseq_ac": "NP_033052", "gene_names_uniprotkb": "Rasd1; Dexras1", "gene_names_refseq": "Dexras1; Rasd1", "protein_names_uniprotkb": "Dexamethasone-induced Ras-related protein 1", "protein_names_refseq": "dexamethasone-induced Ras-related protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19416)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11086993;12573527;15339652;29593295;31406150;32335074;34014836;9452419", "class_list": "", "function": "Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis. Publication Status: Online-Only, [RefSeq, PubMed]; Dexras1 is critical for maintaining the equilibrium between adipogenesis and osteogenesis upon steroid treatment., [RefSeq, PubMed]; Genetic deletion of Dexras1 reduces photic entrainment by eliminating a pertussis-sensitive circadian response to NMDA. Mechanistically, Dexras1 couples NMDA and light input to Gi/o and ERK activation. In, [RefSeq, PubMed]; MiR-375 acts as a novel factor modulating pituitary prolactin synthesis through Rasd1 and Esr1. Publication Status: Online-Only, [RefSeq, PubMed]; Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity)., [UniProtKB]; Study reveals Dexras1 as an important stage-specific regulator of exercise-induced neurogenesis in the adult hippocampus by enhancing pro-mitogenic signaling to neural progenitor cells and modulating cell survival. Publication Status: Online-Only, [RefSeq, PubMed]; The Dexamethasone-induced RAS protein 1 (Dexras1) gene is a cycling gene in the suprachiasmatic nucleus, [RefSeq, PubMed]; This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0007165 signal transduction;GO:0045892 negative regulation of DNA-templated transcription;GO:0007263 nitric oxide mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35626-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PJ0-1", "uniprot_id": "NTRI_MOUSE", "mass": 37984.0, "length": 344, "protein_name": "Neurotrimin", "gene_name": "Ntm", "organism": "Mouse", "refseq_name": "neurotrimin isoform 6 precursor", "refseq_ac": "NP_001344531", "gene_names_uniprotkb": "Ntm; Hnt; Nt", "gene_names_refseq": "6230410L23Rik; B230210G24Rik; Hnt; Igdcc2; Ntm", "protein_names_uniprotkb": "Neurotrimin", "protein_names_refseq": "neurotrimin isoform 6 precursor", "tax_id": 10090, "disease": "primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); uterine fibroid (Disease Ontology:DOID:13223); ovary epithelial cancer (Disease Ontology:DOID:2152); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (R-MMU-163125)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22645316;30899004;33300544", "class_list": "", "function": "Neural cell adhesion molecule., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 5, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0010977 negative regulation of neuron projection development;GO:0060253 negative regulation of glial cell proliferation;GO:0051963 regulation of synapse assembly;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q99PJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C262-1", "uniprot_id": "IIGP5_MOUSE", "mass": 45145.0, "length": 412, "protein_name": "Interferon-inducible GTPase 5", "gene_name": "Irgc", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Irgc; Gm1102; Iigp5; Irgc1", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon-inducible GTPase 5; 3.6.5.-; Immunity-related GTPase cinema 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:210145)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;35618043;37195149", "class_list": "", "function": "GTPase required for sperm motility and therefore male fertility, via positive regulation of spermatozoa fibrous sheath formation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0097226 sperm mitochondrial sheath;GO:0005811 lipid droplet;GO:0016020 membrane;GO:0036126 sperm flagellum", "go_biological_process": "GO:1902093 positive regulation of flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C262-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0P5X1-1", "uniprot_id": "LRIQ1_MOUSE", "mass": 191812.0, "length": 1673, "protein_name": "Leucine-rich repeat- and IQ domain-containing protein 1", "gene_name": "Lrriq1", "organism": "Mouse", "refseq_name": "leucine-rich repeat- and IQ domain-containing protein 1 isoform 1", "refseq_ac": "NP_001157031", "gene_names_uniprotkb": "Lrriq1", "gene_names_refseq": "4930503E15Rik; Gm1557; Lrriq1", "protein_names_uniprotkb": "Leucine-rich repeat- and IQ domain-containing protein 1", "protein_names_refseq": "IQ domain-containing protein LRRIQ1; leucine-rich repeat and IQ domain-containing protein 1; leucine-rich repeat- and IQ domain-containing protein 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74978)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;34887587;36129630;36210013", "class_list": "", "function": "Lrriq1 is an essential factor for fertility by suppressing apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYL6;Q9CUK8", "ec_number_list": "", "go_molecular_function": "GO:0030620 U2 snRNA binding", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0005634 nucleus", "go_biological_process": "GO:0006915 apoptotic process;GO:0007338 single fertilization;GO:0010467 gene expression;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q0P5X1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R035-1", "uniprot_id": "ICT1_MOUSE", "mass": 23477.0, "length": 206, "protein_name": "Large ribosomal subunit protein mL62", "gene_name": "Mrpl58", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL62 isoform 2 precursor", "refseq_ac": "NP_001334574", "gene_names_uniprotkb": "Mrpl58; Ict1", "gene_names_refseq": "1110001A02Rik; 1110002E03Rik; Ict1; MRP-L58; Mrpl58", "protein_names_uniprotkb": "Large ribosomal subunit protein mL62; 3.1.1.29; 39S ribosomal protein L58, mitochondrial; Immature colon carcinoma transcript 1 protein homolog; MRP-L58; Peptidyl-tRNA hydrolase ICT1, mitochondrial", "protein_names_refseq": "39S ribosomal protein L58, mitochondrial; immature colon carcinoma transcript 1 protein homolog; large ribosomal subunit protein mL62 isoform 2 precursor; large ribosomal subunit protein mL62; peptidyl-tRNA hydrolase ICT1, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:68572); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "20869366;21750661;25605945;27029019;30084848;30779550;34428180", "class_list": "", "function": "Because ICT1 is essential in human cells, these results suggest that ribosome rescue activity in mitochondria is required in humans Publication Status: Online-Only, [RefSeq, PubMed]; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit (PubMed:20869366). Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity)., [UniProtKB, PubMed, UniProtKB]; Solution structure of the catalytic domain of the ICT1 protein that lacks an N-terminal mitochondrial targeting signal and an unstructured C-terminal basic-residue-rich extension, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A6T2;A2A6T3;Q3TUL0;Q9CTK1;Q9D1R3", "ec_number_list": "3.1.1.29;7.1.1.9;7.1.1.2;3.6.5.-", "go_molecular_function": "GO:0004045 peptidyl-tRNA hydrolase activity;GO:0016150 translation release factor activity, codon nonspecific;GO:0003747 translation release factor activity", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0070126 mitochondrial translational termination;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R035-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PD21-1", "uniprot_id": "SHB_MOUSE", "mass": 54708.0, "length": 503, "protein_name": "SH2 domain-containing adapter protein B", "gene_name": "Shb", "organism": "Mouse", "refseq_name": "SH2 domain-containing adapter protein B", "refseq_ac": "NP_001028478", "gene_names_uniprotkb": "Shb", "gene_names_refseq": "Shb", "protein_names_uniprotkb": "SH2 domain-containing adapter protein B", "protein_names_refseq": "SH2 domain-containing adapter protein B", "tax_id": 10090, "disease": "", "pathway": " (mmu:230126); (R-MMU-4420097)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12181353;17242355;19144319;21183079;21750661;32441314;33220260;8302579;8777141", "class_list": "", "function": "Absence of the Shb gene in mixed-lineage leukemia MLL-AF9 cells increases latency in mice despite higher proliferation rates in vitro., [RefSeq, PubMed]; Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells (By similarity)., [UniProtKB]; Pericyte dysfunction due to Shb gene deficiency increases B16F10 melanoma lung metastasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AKW3;Q3ULM3", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0001525 angiogenesis;GO:0045931 positive regulation of mitotic cell cycle;GO:0006469 negative regulation of protein kinase activity;GO:0006915 apoptotic process;GO:0050852 T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6PD21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1T6-1", "uniprot_id": "LY66E_MOUSE", "mass": 18197.0, "length": 166, "protein_name": "Lymphocyte antigen 6G6e", "gene_name": "Ly6g6e", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6G6e isoform a precursor", "refseq_ac": "NP_081642", "gene_names_uniprotkb": "Ly6g6e", "gene_names_refseq": "2310011I02Rik; G6e; Ly6g6e", "protein_names_uniprotkb": "Lymphocyte antigen 6G6e; Lymphocyte antigen 6 complex locus protein G6e", "protein_names_refseq": "lymphocyte antigen 6 complex G6E; lymphocyte antigen 6 complex locus protein G6e; lymphocyte antigen 6 complex, locus G6E; lymphocyte antigen 6G6e isoform a precursor; lymphocyte antigen 6G6e", "tax_id": 10090, "disease": "", "pathway": " (mmu:70274)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12079290;17008713;21750661;26276394", "class_list": "", "function": "Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro potentiates alpha-3:beta-4-containing nAChRs maximum response by increasing peak current and slowing down receptor desensitization; the activity is dependent on its cell surface localization., [UniProtKB, PubMed]; Lynx2 and Ly6g6e have roles in intracellular trafficking and allosteric potentiation of alpha4beta2 nAChRs, respectively, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7E5", "ec_number_list": "", "go_molecular_function": "GO:0030549 acetylcholine receptor activator activity;GO:0033130 acetylcholine receptor binding;GO:0004675 transmembrane receptor protein serine/threonine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045202 synapse;GO:0042995 cell projection", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway;GO:0002029 desensitization of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K1T6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K375-1", "uniprot_id": "LRC56_MOUSE", "mass": 60483.0, "length": 552, "protein_name": "Leucine-rich repeat-containing protein 56", "gene_name": "Lrrc56", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 56 isoform a", "refseq_ac": "NP_001165535", "gene_names_uniprotkb": "Lrrc56", "gene_names_refseq": "5730427C23Rik; Lrrc56; mFLJ00101", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 56", "protein_names_refseq": "leucine-rich repeat-containing protein 56 isoform a; leucine-rich repeat-containing protein 56", "tax_id": 10090, "disease": "primary ciliary dyskinesia 39 (Disease Ontology:DOID:0111854)", "pathway": " (mmu:70552)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Required for the assembly of dynein arms., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q571F2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K375-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0U6-1", "uniprot_id": "MAF1_MOUSE", "mass": 28780.0, "length": 258, "protein_name": "Repressor of RNA polymerase III transcription MAF1 homolog", "gene_name": "Maf1", "organism": "Mouse", "refseq_name": "repressor of RNA polymerase III transcription MAF1 homolog", "refseq_ac": "NP_001158079", "gene_names_uniprotkb": "Maf1", "gene_names_refseq": "1110068E11Rik; Maf1", "protein_names_uniprotkb": "Repressor of RNA polymerase III transcription MAF1 homolog", "protein_names_refseq": "repressor of RNA polymerase III transcription MAF1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68877); (R-MMU-8943724)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "20543138;21750661;25934505;30110641;30429315;35611941;36402285;38226680", "class_list": "", "function": "Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA., [UniProtKB, UniProtKB]; MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass. Publication Status: Online-Only, [RefSeq, PubMed]; Maf1 is an intrinsic suppressor against spontaneous neural repair and functional recovery after ischemic stroke., [RefSeq, PubMed]; Maf1 loss regulates spinogenesis and attenuates cognitive impairment in Alzheimer's disease., [RefSeq, PubMed]; Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (By similarity). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (PubMed:30110641). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB. When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout. Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4U3;Q91W84", "ec_number_list": "", "go_molecular_function": "GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding;GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding;GO:0050811 GABA receptor binding;GO:0000994 RNA polymerase III core binding;GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016479 negative regulation of transcription by RNA polymerase I;GO:0016480 negative regulation of transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D0U6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7TZF3-1", "uniprot_id": "SKIT4_MOUSE", "mass": 54166.0, "length": 474, "protein_name": "Selection and upkeep of intraepithelial T-cells protein 4", "gene_name": "Skint4", "organism": "Mouse", "refseq_name": "selection and upkeep of intraepithelial T-cells protein 4 isoform 2 precursor", "refseq_ac": "NP_001334109", "gene_names_uniprotkb": "Skint4", "gene_names_refseq": "9530098N22Rik; Skint4", "protein_names_uniprotkb": "Selection and upkeep of intraepithelial T-cells protein 4; Skint-4", "protein_names_refseq": "selection and upkeep of intraepithelial T-cells protein 4 isoform 2 precursor; selection and upkeep of intraepithelial T-cells protein 4; skint 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:320640)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18408721;21750661", "class_list": "", "function": "May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A7TZF4", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A7TZF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQA9-1", "uniprot_id": "NTPCR_MOUSE", "mass": 20667.0, "length": 190, "protein_name": "Cancer-related nucleoside-triphosphatase homolog", "gene_name": "Ntpcr", "organism": "Mouse", "refseq_name": "cancer-related nucleoside-triphosphatase homolog isoform 2", "refseq_ac": "NP_001297617", "gene_names_uniprotkb": "Ntpcr", "gene_names_refseq": "2310079N02Rik; Ntpcr", "protein_names_uniprotkb": "Cancer-related nucleoside-triphosphatase homolog; 3.6.1.15; NTPase; Nucleoside triphosphate phosphohydrolase", "protein_names_refseq": "NTPase; cancer-related nucleoside-triphosphatase homolog isoform 2; cancer-related nucleoside-triphosphatase homolog; nucleoside triphosphate phosphohydrolase; nucleoside-triphosphatase C1orf57 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66566)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180", "class_list": "", "function": "Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.6.5.2;3.1.13.1;5.6.2.6;3.6.5.3;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;3.6.5.4;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.5.5;3.6.4.6;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;2.7.11.1;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.4.3;3.6.1.6;3.6.1.42", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0017111 ribonucleoside triphosphate phosphatase activity;GO:0043273 CTPase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59110-1", "uniprot_id": "SENP1_MOUSE", "mass": 72511.0, "length": 640, "protein_name": "Sentrin-specific protease 1", "gene_name": "Senp1", "organism": "Mouse", "refseq_name": "sentrin-specific protease 1 isoform 2", "refseq_ac": "NP_659100", "gene_names_uniprotkb": "Senp1; Supr2", "gene_names_refseq": "2310046A20Rik; D15Ertd528e; E330036L07Rik; Senp1; suPr-2", "protein_names_uniprotkb": "Sentrin-specific protease 1; 3.4.22.-; SUMO-1 protease 2; Sentrin/SUMO-specific protease SENP1; SuPr-2", "protein_names_refseq": "SUMO-1 protease 2; SUMO1/sentrin specific protease 1; sentrin-specific protease 1 isoform 2; sentrin-specific protease 1; sentrin/SUMO-specific protease SENP1", "tax_id": 10090, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:223870); (R-MMU-3065679); (R-MMU-9035034)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "15923632;21750661;25428506;29499132;36852467;38309408;38426545;38762158;38992961", "class_list": "", "function": "Data describe a mutation in SENP1 that causes increased steady-state levels of the sumoylated forms of a number of proteins and results in placental abnormalities incompatible with embryonic development., [RefSeq, PubMed]; LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding to SENP1 to promote intestinal fibrosis in Crohn's disease., [RefSeq, PubMed]; Protease that catalyzes two essential functions in the SUMO pathway (PubMed:15923632, PubMed:29499132). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (By similarity). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (By similarity). Deconjugates SUMO1 from HIPK2 (By similarity). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (By similarity). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (By similarity). Deconjugates SUMO2 from MTA1 (By similarity). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (By similarity). Desumoylates CCAR2 which decreases its interaction with SIRT1 (By similarity). Deconjugates SUMO1 from GPS2 (PubMed:29499132)., [UniProtKB, UniProtKB, PubMed, PubMed]; SENP1 attenuates hypoxia-reoxygenation injury in liver sinusoid endothelial cells by relying on the HIF-1alpha signaling pathway., [RefSeq, PubMed]; SENP1 regulates intermittent hypoxia-induced microglia mediated inflammation and cognitive dysfunction via wnt/beta-catenin pathway., [RefSeq, PubMed]; SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTV5;Q8BZF1", "ec_number_list": "3.6.5.2;3.4.22.-;3.6.4.-;1.16.1.-;3.1.3.-;3.1.3.95", "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0070139 SUMO-specific endopeptidase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005925 focal adhesion;GO:0031965 nuclear membrane", "go_biological_process": "GO:0010724 regulation of definitive erythrocyte differentiation;GO:0006508 proteolysis;GO:0016925 protein sumoylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P59110-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVZ5-1", "uniprot_id": "IL33_MOUSE", "mass": 29991.0, "length": 266, "protein_name": "Interleukin-33", "gene_name": "Il33", "organism": "Mouse", "refseq_name": "interleukin-33 isoform 1", "refseq_ac": "NP_001158196", "gene_names_uniprotkb": "Il33", "gene_names_refseq": "9230117N10Rik; Il-33; Il1f11; Il33; NF-HEV", "protein_names_uniprotkb": "Interleukin-33; IL-33", "protein_names_refseq": "interleukin-33 isoform 1; nuclear factor from high endothelial venules", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); obstructive sleep apnea (Disease Ontology:DOID:0050848); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); colitis (Disease Ontology:DOID:0060180); aortic atherosclerosis (Disease Ontology:DOID:10230); common cold (Disease Ontology:DOID:10459); pleural tuberculosis (Disease Ontology:DOID:106); Alzheimer's disease (Disease Ontology:DOID:10652); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); pulmonary edema (Disease Ontology:DOID:11396); paracoccidioidomycosis (Disease Ontology:DOID:12662); gout (Disease Ontology:DOID:13189); clonorchiasis (Disease Ontology:DOID:13767); candidiasis (Disease Ontology:DOID:1508); colon cancer (Disease Ontology:DOID:219); asthma (Disease Ontology:DOID:2841); tuberculosis (Disease Ontology:DOID:399); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); peptic ulcer disease (Disease Ontology:DOID:750); herpes simplex (Disease Ontology:DOID:8566); ulcerative colitis (Disease Ontology:DOID:8577); diabetes mellitus (Disease Ontology:DOID:9351); acute myocardial infarction (Disease Ontology:DOID:9408); allergic asthma (Disease Ontology:DOID:9415); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (mmu:77125); (R-MMU-1257604); (R-MMU-5689880); (R-MMU-6811558); (R-MMU-9014843)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;16286016;17185418;19465481;21734074;21750661;22307629;29045903;34644537;35749514;35794369", "class_list": "", "function": "Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:29045903). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines (By similarity). Also involved in activation of mast cells, basophils, eosinophils and natural killer cells (By similarity). Acts as an enhancer of polarization of alternatively activated macrophages (By similarity). Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (PubMed:34644537)., [UniProtKB, UniProtKB, PubMed, PubMed]; IL-33 is a dual function protein that may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties., [RefSeq, PubMed]; IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells, [RefSeq, PubMed]; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (By similarity). This form is rapidely lost upon angiogenic or pro-inflammatory activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 26, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2YEJ4;Q3TQN0;Q99L46", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0002112 interleukin-33 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030133 transport vesicle", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0043032 positive regulation of macrophage activation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BVZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08843-1", "uniprot_id": "LST1_MOUSE", "mass": 10325.0, "length": 95, "protein_name": "Leukocyte-specific transcript 1 protein", "gene_name": "Lst1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Lst1; B144", "gene_names_refseq": "", "protein_names_uniprotkb": "Leukocyte-specific transcript 1 protein; Protein B144", "protein_names_refseq": "", "tax_id": 10090, "disease": "graft-versus-host disease (Disease Ontology:DOID:0081267)", "pathway": " (mmu:16988)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11478849;19144319;21750661;3117682;9367684", "class_list": "", "function": "Possible role in modulating immune responses. Has an inhibitory effect on lymphocyte proliferation. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08844;Q9Z1H3;Q9Z1R0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0016358 dendrite development;GO:0000902 cell morphogenesis;GO:0008360 regulation of cell shape;GO:0050672 negative regulation of lymphocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08843-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSG5-1", "uniprot_id": "SH321_MOUSE", "mass": 60324.0, "length": 549, "protein_name": "SH3 domain-containing protein 21", "gene_name": "Sh3d21", "organism": "Mouse", "refseq_name": "SH3 domain-containing protein 21 isoform 2", "refseq_ac": "NP_080132", "gene_names_uniprotkb": "Sh3d21", "gene_names_refseq": "1700029G01Rik; Mnmip1; Sh3d21", "protein_names_uniprotkb": "SH3 domain-containing protein 21", "protein_names_refseq": "SH3 domain containing 21; SH3 domain-containing protein 21 isoform 2; SH3 domain-containing protein 21; SH3 domain-containing protein C1orf113 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66938)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AW04;Q3U2S3", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "", "go_biological_process": "GO:0007015 actin filament organization;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TSG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQM9-1", "uniprot_id": "MD12L_MOUSE", "mass": 241426.0, "length": 2157, "protein_name": "Mediator of RNA polymerase II transcription subunit 12-like protein", "gene_name": "Med12l", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 12-like protein", "refseq_ac": "NP_808523", "gene_names_uniprotkb": "Med12l; Kiaa3007", "gene_names_refseq": "A130035F20; A630079M02; Med12l; TRALPUSH", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 12-like protein; Mediator complex subunit 12-like protein", "protein_names_refseq": "mediator complex subunit 12-like protein; mediator of RNA polymerase II transcription subunit 12-like protein; mediator of RNA polymerase II transcription, subunit 12 homolog-like; no opposite paired repeat protein", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:329650)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;35820727", "class_list": "", "function": "May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPF2;Q8C9E3", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008013 beta-catenin binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BQM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVL3-1", "uniprot_id": "SNX17_MOUSE", "mass": 52797.0, "length": 470, "protein_name": "Sorting nexin-17", "gene_name": "Snx17", "organism": "Mouse", "refseq_name": "sorting nexin-17 isoform a", "refseq_ac": "NP_710147", "gene_names_uniprotkb": "Snx17", "gene_names_refseq": "5830447M19Rik; D5Ertd260e; Snx17; b2b1625.1Clo; mKIAA0064", "protein_names_uniprotkb": "Sorting nexin-17", "protein_names_refseq": "sorting nexin-17 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:266781)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12169628;16052210;18276590;19144319;19967056;21183079;21750661;21913724;25605945;26740625;34428180;36311763;37704928;37828378", "class_list": "", "function": "Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:12169628, PubMed:16052210). Binds to NPxY sequences in the cytoplasmic tails of target cargos (By similarity). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (By similarity). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16052210, PubMed:18276590). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; SNX17 Mediates Dendritic Spine Maturation via p140Cap., [RefSeq, PubMed]; SNX17 regulates amyloid precursor protein trafficking and processing in the early endosomes, [RefSeq, PubMed]; Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0N8", "ec_number_list": "", "go_molecular_function": "GO:0050750 low-density lipoprotein particle receptor binding;GO:0035091 phosphatidylinositol binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007165 signal transduction;GO:0001822 kidney development;GO:0006898 receptor-mediated endocytosis;GO:0035904 aorta development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BVL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27931-1", "uniprot_id": "IL1R2_MOUSE", "mass": 45645.0, "length": 410, "protein_name": "Interleukin-1 receptor type 2", "gene_name": "Il1r2", "organism": "Mouse", "refseq_name": "interleukin-1 receptor type 2 isoform 2 precursor", "refseq_ac": "NP_034685", "gene_names_uniprotkb": "Il1r2; Il-1r2; Il1rb", "gene_names_refseq": "CD121b; Il1r-2; Il1r2", "protein_names_uniprotkb": "Interleukin-1 receptor type 2; CD121 antigen-like family member B; IL-1 type II receptor; IL-1R-2; IL-1R-beta; IL-1RT-2; IL-1RT2; Interleukin-1 receptor beta; Interleukin-1 receptor type II", "protein_names_refseq": "CD121 antigen-like family member B; IL-1 receptor beta chain; IL-1 type II receptor; IL-1R-2; IL-1R-beta; IL-1RT-2; IL-1RT2; interleukin-1 receptor beta; interleukin-1 receptor type 2 isoform 2 precursor; interleukin-1 receptor type 2", "tax_id": 10090, "disease": "organ system cancer (Disease Ontology:DOID:0050686); lung cancer (Disease Ontology:DOID:1324); aggressive periodontitis (Disease Ontology:DOID:1474); lung adenocarcinoma (Disease Ontology:DOID:3910); cholangiocarcinoma (Disease Ontology:DOID:4947); esophageal cancer (Disease Ontology:DOID:5041)", "pathway": " (mmu:16178); (R-MMU-9020702)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15986350;16944957;1833184;21750661;38329807;8332913;9662436", "class_list": "", "function": "Loss of T follicular regulatory cell-derived IL-1R2 augments germinal center reactions via increased IL-1. Publication Status: Online-Only, [RefSeq, PubMed]; Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019966 interleukin-1 binding;GO:0004908 interleukin-1 receptor activity;GO:0004910 interleukin-1, type II, blocking receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045323 interleukin-1 receptor complex", "go_biological_process": "GO:2000660 negative regulation of interleukin-1-mediated signaling pathway;GO:0007166 cell surface receptor signaling pathway;GO:1900016 negative regulation of cytokine production involved in inflammatory response;GO:0010955 negative regulation of protein processing;GO:0032690 negative regulation of interleukin-1 alpha production", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P27931-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB40-1", "uniprot_id": "MED27_MOUSE", "mass": 35298.0, "length": 311, "protein_name": "Mediator of RNA polymerase II transcription subunit 27", "gene_name": "Med27", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 27 isoform d", "refseq_ac": "NP_001277419", "gene_names_uniprotkb": "Med27; Crsp8", "gene_names_refseq": "1500015J03Rik; 2310042P07Rik; Crsp8; D2Ertd434e; Med27", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 27; CRSP complex subunit 8; Cofactor required for Sp1 transcriptional activation subunit 8; Mediator complex subunit 27", "protein_names_refseq": "CRSP complex subunit 8; cofactor required for Sp1 transcriptional activation, subunit 8; mediator of RNA polymerase II transcription subunit 27 isoform d; mediator of RNA polymerase II transcription subunit 27; transcriptional co-activator CRSP8 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68975)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "18299400;19224205;20173027;21750661;25428506;30084848;30779550;31219806;31599954;34203471;34428180;35820727;39209248", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]; The essential role of MED27 in stabilizing the mediator complex for cardiac development and function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJV2;Q78JI3;Q9D707", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0019827 stem cell population maintenance;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9DB40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76K27-1", "uniprot_id": "SIAT2_MOUSE", "mass": 60192.0, "length": 524, "protein_name": "Beta-galactoside alpha-2,6-sialyltransferase 2", "gene_name": "St6gal2", "organism": "Mouse", "refseq_name": "beta-galactoside alpha-2,6-sialyltransferase 2", "refseq_ac": "NP_001334332", "gene_names_uniprotkb": "St6gal2; Kiaa1877", "gene_names_refseq": "C230064G14Rik; St6gal2; St6galII; mKIAA1877", "protein_names_uniprotkb": "Beta-galactoside alpha-2,6-sialyltransferase 2; 2.4.3.1; Alpha 2,6-ST 2; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2; ST6Gal II; ST6GalII; Sialyltransferase 2", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase 2; beta-galactoside alpha-2,6-sialyltransferase 2; beta-galactoside alpha-2,6-sialyltransferase II", "tax_id": 10090, "disease": "", "pathway": " (mmu:240119); (R-MMU-4085001)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12966079;21750661;31219806;33242079", "class_list": "glycogene;glycosyltransferase", "function": "Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes., [RefSeq, PubMed]; Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A9C434;Q6ZPG5;Q8BUU4", "ec_number_list": "2.4.3.1", "go_molecular_function": "GO:0008373 sialyltransferase activity;GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006054 N-acetylneuraminate metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0009311 oligosaccharide metabolic process;GO:0097503 sialylation", "synthesized_glycan_count": 1722, "hit_score": 1.2, "record_id": "Q76K27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5NC83-1", "uniprot_id": "SMIP7_MOUSE", "mass": 50400.0, "length": 441, "protein_name": "Protein SPMIP7", "gene_name": "Spmip7", "organism": "Mouse", "refseq_name": "protein SPMIP7 isoform 2", "refseq_ac": "NP_082945", "gene_names_uniprotkb": "Spmip7; 4930415F15Rik; Pms1; Spata48", "gene_names_refseq": "4930415F15Rik; Spata48; Spmip7", "protein_names_uniprotkb": "Protein SPMIP7; Post-meiotic spermatogenesis protein 1; Sperm microtubule inner protein 7; Spermatogenesis-associated protein 48", "protein_names_refseq": "post meiotic spermatogenesis 1; post-meiotic spermatogenesis protein 1; protein SPMIP7 isoform 2; protein SPMIP7; spermatogenesis associated 48; spermatogenesis-associated protein 48; uncharacterized protein C7orf72 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73862)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;22110678;29700843", "class_list": "", "function": "Essential for normal spermatogenesis., [UniProtKB, PubMed]; In humans and mice with azoospermia, expression of SPATA48 disappeared in the testis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D5M8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5NC83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99P58-1", "uniprot_id": "RB27B_MOUSE", "mass": 24560.0, "length": 218, "protein_name": "Ras-related protein Rab-27B", "gene_name": "Rab27b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-27B isoform 1", "refseq_ac": "NP_001076022", "gene_names_uniprotkb": "Rab27b", "gene_names_refseq": "2310021G14Rik; B130064M09Rik; Rab27b", "protein_names_uniprotkb": "Ras-related protein Rab-27B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-27B isoform 1; ras-related protein Rab-27B", "tax_id": 10090, "disease": "platelet storage pool deficiency (Disease Ontology:DOID:2223)", "pathway": " (mmu:80718); (R-MMU-114608); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "11178108;11956164;12060386;12122117;12221080;12578829;16716193;18940604;35701443;37317963", "class_list": "", "function": "Chromosomal mapping and gene structure of the RAB27B gene., [RefSeq, PubMed]; Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse. Publication Status: Online-Only, [RefSeq, PubMed]; RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; Rab27b is functionally redundant with Rab27a and the pathogenesis of Griscelli syndrome is determined by the relative expression of Rab27a and Rab27b in specialized cell types. Erratum:[J Clin Invest 2002 Oct;110(8):1213], [RefSeq, PubMed]; Rab27b is involved in pituitary hormone secretion, [RefSeq, PubMed]; Rab27b may regulate the outward movement of melanosomes and the formation or maintenance of dendritic extensions in melanocytes., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB27B regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIX0", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;2.5.1.60;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0016324 apical plasma membrane;GO:0042470 melanosome;GO:0005770 late endosome", "go_biological_process": "GO:0071985 multivesicular body sorting pathway;GO:0099641 anterograde axonal protein transport;GO:0006887 exocytosis;GO:0045921 positive regulation of exocytosis;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99P58-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60857-1", "uniprot_id": "SC6A4_MOUSE", "mass": 70048.0, "length": 630, "protein_name": "Sodium-dependent serotonin transporter", "gene_name": "Slc6a4", "organism": "Mouse", "refseq_name": "sodium-dependent serotonin transporter", "refseq_ac": "NP_034614", "gene_names_uniprotkb": "Slc6a4; Htt; Sert", "gene_names_refseq": "5-HTT; Htt; Sert; Slc6a4", "protein_names_uniprotkb": "Sodium-dependent serotonin transporter; 5HT transporter; 5HTT; SERT; Solute carrier family 6 member 4", "protein_names_refseq": "5-hydroxytryptamine (serotonin) transporter; 5HT transporter; 5HTT; Sodium-dependent serotonin transporter (5HT transporter) (5HTT); sodium-dependent serotonin transporter; solute carrier family 6 member 4", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); obstructive sleep apnea (Disease Ontology:DOID:0050848); autism spectrum disorder (Disease Ontology:DOID:0060041); alexithymia (Disease Ontology:DOID:0060131); Parkinsonism (Disease Ontology:DOID:0080855); obsessive-compulsive disorder (Disease Ontology:DOID:10933); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); heart disease (Disease Ontology:DOID:114); dengue hemorrhagic fever (Disease Ontology:DOID:12206); autistic disorder (Disease Ontology:DOID:12849); generalized anxiety disorder (Disease Ontology:DOID:14320); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); asthma (Disease Ontology:DOID:2841); substance abuse (Disease Ontology:DOID:302); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bipolar disorder (Disease Ontology:DOID:3312); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); liver cirrhosis (Disease Ontology:DOID:5082); borna disease (Disease Ontology:DOID:5154); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); diverticulitis (Disease Ontology:DOID:7475); cocaine abuse (Disease Ontology:DOID:809); chronic fatigue syndrome (Disease Ontology:DOID:8544); sudden infant death syndrome (Disease Ontology:DOID:9007); leishmaniasis (Disease Ontology:DOID:9065); brain disease (Disease Ontology:DOID:936)", "pathway": " (mmu:15567); (R-MMU-380615); (R-MMU-442660)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "16803896;17452640;18317590;20676059;21750661;22572884;25600870;27111230;29038237;8507984;9037532;9073170;9547354", "class_list": "", "function": "Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (By similarity) (PubMed:9037532, PubMed:9547354). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (PubMed:25600870, PubMed:9547354). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (PubMed:27111230). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (By similarity) (PubMed:9037532, PubMed:9547354). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35241;Q5NCR6", "ec_number_list": "", "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0005178 integrin binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0051378 serotonin binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0045121 membrane raft;GO:0045202 synapse", "go_biological_process": "GO:0046621 negative regulation of organ growth;GO:0021941 negative regulation of cerebellar granule cell precursor proliferation;GO:0048484 enteric nervous system development;GO:0060179 male mating behavior;GO:0015844 monoamine transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q60857-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88834-1", "uniprot_id": "SHD_MOUSE", "mass": 38481.0, "length": 343, "protein_name": "SH2 domain-containing adapter protein D", "gene_name": "Shd", "organism": "Mouse", "refseq_name": "SH2 domain-containing adapter protein D isoform 1", "refseq_ac": "NP_001152995", "gene_names_uniprotkb": "Shd", "gene_names_refseq": "Shd", "protein_names_uniprotkb": "SH2 domain-containing adapter protein D", "protein_names_refseq": "SH2 domain-containing adapter protein D isoform 1; SH2 domain-containing adapter protein D", "tax_id": 10090, "disease": "", "pathway": " (mmu:20420)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;9315092", "class_list": "", "function": "May function as an adapter protein., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYI7", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88834-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BNX7-1", "uniprot_id": "NRAC_MOUSE", "mass": 18347.0, "length": 165, "protein_name": "Nutritionally-regulated adipose and cardiac-enriched protein", "gene_name": "A530016L24Rik; Nrac", "organism": "Mouse", "refseq_name": "nutritionally-regulated adipose and cardiac-enriched protein", "refseq_ac": "NP_796013", "gene_names_uniprotkb": "A530016L24Rik; Nrac", "gene_names_refseq": "A530016L24Rik; Nrac", "protein_names_uniprotkb": "Nutritionally-regulated adipose and cardiac-enriched protein", "protein_names_refseq": "nutritionally-regulated adipose and cardiac-enriched protein; transmembrane protein C14orf180 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:319942)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;23029450", "class_list": "", "function": "Nrac (gene A530016L24Rik) is localized to the plasma membrane, and highly induced during adipocyte differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0Q1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BNX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BPP5-1", "uniprot_id": "LYPD6_MOUSE", "mass": 19065.0, "length": 171, "protein_name": "Ly6/PLAUR domain-containing protein 6", "gene_name": "Lypd6", "organism": "Mouse", "refseq_name": "ly6/PLAUR domain-containing protein 6 precursor", "refseq_ac": "NP_796113", "gene_names_uniprotkb": "Lypd6", "gene_names_refseq": "E130115E03Rik; Lypd6", "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 6", "protein_names_refseq": "ly6/PLAUR domain-containing protein 6 precursor; ly6/PLAUR domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:320343)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19403274;21750661;23987510;25680266;32467358", "class_list": "", "function": "Activation of Somatostatin Interneurons by Nicotinic Modulator Lypd6 Enhances Plasticity and Functional Recovery in the Adult Mouse Visual Cortex., [RefSeq, PubMed]; Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain (PubMed:19403274). Inhibits nicotine-induced Ca(2+) influx through nAChRs (By similarity). In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner (By similarity). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Lypd6 appears to control Lrp6 activation specifically in membrane rafts, which is essential for downstream signaling., [RefSeq, PubMed]; Lypd6 seems to constitute a novel modulator of nAChRs that affects receptor function by selectively increasing Ca2+-influx through ion channels, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030548 acetylcholine receptor regulator activity;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007399 nervous system development;GO:0048167 regulation of synaptic plasticity;GO:0007601 visual perception;GO:0030182 neuron differentiation;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BPP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHI8-1", "uniprot_id": "NOX4_MOUSE", "mass": 66519.0, "length": 578, "protein_name": "NADPH oxidase 4", "gene_name": "Nox4", "organism": "Mouse", "refseq_name": "NADPH oxidase 4 isoform 1", "refseq_ac": "NP_056575", "gene_names_uniprotkb": "Nox4; Renox", "gene_names_refseq": "Nox4", "protein_names_uniprotkb": "NADPH oxidase 4; 1.6.3.1; KOX-1; Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase; Superoxide-generating NADPH oxidase 4", "protein_names_refseq": "KOX-1; NADPH oxidase 4 isoform 1; kidney oxidase-1; kidney superoxide-producing NADPH oxidase; renal NAD(P)H-oxidase; superoxide-generating NADPH oxidase 4", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); hypertension (Disease Ontology:DOID:10763); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:50490); (R-MMU-3299685)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10869423;11032835;11098048;12855428;15016652;15638999;15802177;21750661;23393389;25428506;27525436;30084848;34428180;35820727;38748682;38776855;38910308;38920138", "class_list": "", "function": "Effects of Nox4 upregulation on PECAM-1 expression in a mouse model of diabetic retinopathy. Publication Status: Online-Only, [RefSeq, PubMed]; GDF11 OVEREXPRESSION ALLEVIATES SEPSIS-INDUCED LUNG MICROVASCULAR ENDOTHELIAL BARRIER DAMAGE BY ACTIVATING SIRT1/NOX4 SIGNALING TO INHIBIT FERROPTOSIS., [RefSeq, PubMed]; Hederagenin improves renal fibrosis in diabetic nephropathy by regulating Smad3/NOX4/SLC7A11 signaling-mediated tubular cell ferroptosis., [RefSeq, PubMed]; NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 (By similarity). Can also catalyze to a smaller extent, the reduction of oxygen to superoxide (PubMed:10869423, PubMed:11098048, PubMed:15638999). May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity (By similarity). May regulate insulin signaling cascade (By similarity). May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (By similarity). May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation (By similarity). Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; NADPH oxidase that catalyzes the reduction of oxygen to H2O2. Reactive oxygen species production activates MAPK1/MAPK3 signaling and leads to the activation of ELK1 transcription factor., [UniProtKB, PubMed]; NOX4 and its association with myeloperoxidase and osteopontin in regulating endochondral ossification., [RefSeq, PubMed]; Neutrophil subunit gp91phox contributes to NADPH oxidase function in vascular fibroblasts, but not vascular smooth muscle cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B5AN18;Q3TF39;Q8C3M1;Q8VCA3", "ec_number_list": "1.6.3.1;1.11.1.-;1.-.-.-;1.14.13.8;1.6.99.1;1.6.3.-;1.14.13.225", "go_molecular_function": "GO:0020037 heme binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:1990782 protein tyrosine kinase binding;GO:0072341 modified amino acid binding;GO:0016175 superoxide-generating NAD(P)H oxidase activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0010729 positive regulation of hydrogen peroxide biosynthetic process;GO:0006952 defense response;GO:0008285 negative regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9JHI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJH2-1", "uniprot_id": "MCTP2_MOUSE", "mass": 100178.0, "length": 878, "protein_name": "Multiple C2 and transmembrane domain-containing protein 2", "gene_name": "Mctp2", "organism": "Mouse", "refseq_name": "multiple C2 and transmembrane domain-containing protein 2", "refseq_ac": "NP_001019874", "gene_names_uniprotkb": "Mctp2; Gm489", "gene_names_refseq": "Gm489; Mctp2", "protein_names_uniprotkb": "Multiple C2 and transmembrane domain-containing protein 2", "protein_names_refseq": "multiple C2 and transmembrane domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:244049)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;23773997;31599954;34428180;35820727;39627609", "class_list": "", "function": "Might play a role in the development of cardiac outflow tract., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0046928 regulation of neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5RJH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D752-1", "uniprot_id": "MD2L2_MOUSE", "mass": 24402.0, "length": 211, "protein_name": "Mitotic spindle assembly checkpoint protein MAD2B", "gene_name": "Mad2l2", "organism": "Mouse", "refseq_name": "mitotic spindle assembly checkpoint protein MAD2B", "refseq_ac": "NP_001292349", "gene_names_uniprotkb": "Mad2l2; Mad2b; Rev7", "gene_names_refseq": "2310033C13Rik; G1-453-4; MAD2B; Mad2l2; REV7; repro22", "protein_names_uniprotkb": "Mitotic spindle assembly checkpoint protein MAD2B; MAD2-like protein 2; Mitotic arrest deficient 2-like protein 2", "protein_names_refseq": "MAD2-like protein 2; mitotic arrest deficient 2-like protein 2; mitotic spindle assembly checkpoint protein MAD2B", "tax_id": 10090, "disease": "Fanconi anemia complementation group V (Disease Ontology:DOID:0111080)", "pathway": " (mmu:71890); (R-MMU-110312); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "14657033;21750661;22700975;22859295;34428180;36573299;37958783", "class_list": "", "function": "Adapter protein able to interact with different proteins and involved in different biological processes (By similarity). Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis (PubMed:22859295). Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation. Forms a quaternary complex with POLK, REV1 and REV3L, where REV3L-bound MAD2L2 and POLK are able to bind simultaneously to REV1 forming the stable translesion synthesis (TLS) machinery therefore bridging the inserter and extender polymerases (PubMed:22859295)., [UniProtKB, UniProtKB, PubMed]; Identification of the Rev7 binding surface of the Rev1 C-terminal domain, [RefSeq, PubMed]; MAD2B Blunts Chronic Unpredictable Stress and Corticosterone Stimulation-Induced Depression-Like Behaviors in Mice., [RefSeq, PubMed]; REV7 Monomer Is Unable to Participate in Double Strand Break Repair and Translesion Synthesis but Suppresses Mitotic Errors. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMY6;Q91VP1", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0000785 chromatin", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0043247 telomere maintenance in response to DNA damage;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D752-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3ZT31-1", "uniprot_id": "SNX25_MOUSE", "mass": 97146.0, "length": 840, "protein_name": "Sorting nexin-25", "gene_name": "Snx25", "organism": "Mouse", "refseq_name": "sorting nexin-25 isoform 3", "refseq_ac": "NP_997096", "gene_names_uniprotkb": "Snx25", "gene_names_refseq": "Gm1699; Gm173; Sbbi31; Snx25", "protein_names_uniprotkb": "Sorting nexin-25", "protein_names_refseq": "sorting nexin-25 isoform 3", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 20 (Disease Ontology:DOID:0080066)", "pathway": " (mmu:102141)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;32156614;32955616;34428180;35820727;36210013;38936254", "class_list": "", "function": "Circadian rhythms of sorting nexin 25 in the mouse suprachiasmatic nucleus., [RefSeq, PubMed]; May be involved in several stages of intracellular trafficking., [UniProtKB]; Neural expression of sorting nexin 25 and its regulation of tyrosine receptor kinase B trafficking., [RefSeq, PubMed]; Redox-modulated SNX25 as a novel regulator of GPCR-G protein signaling from endosomes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QMG5;Q6PGF1", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0034713 type I transforming growth factor beta receptor binding", "go_cellular_component": "GO:0005768 endosome;GO:0010008 endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032801 receptor catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3ZT31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKJ9-1", "uniprot_id": "SIR7_MOUSE", "mass": 45146.0, "length": 402, "protein_name": "NAD-dependent protein deacetylase sirtuin-7", "gene_name": "Sirt7", "organism": "Mouse", "refseq_name": "NAD-dependent protein deacetylase sirtuin-7 isoform 1", "refseq_ac": "NP_694696", "gene_names_uniprotkb": "Sirt7; Sir2l7", "gene_names_refseq": "Sirt7", "protein_names_uniprotkb": "NAD-dependent protein deacetylase sirtuin-7; 2.3.1.-; 2.3.1.286; NAD-dependent protein deacylase sirtuin-7; Regulatory protein SIR2 homolog 7; SIR2-like protein 7", "protein_names_refseq": "NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacetylase sirtuin-7 isoform 1; NAD-dependent protein deacetylase sirtuin-7; NAD-dependent protein deacylase sirtuin-7; SIR2-like protein 7; regulatory protein SIR2 homolog 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:209011)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "16618798;18239138;19261981;21750661;22872234;25200183;27225932;28842251;28923965;30026585;30779550;31075303;31226208;31256246;39053861;39287444", "class_list": "", "function": "NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase and deglutarylase), depending on the context (PubMed:25200183, PubMed:30026585, PubMed:31075303). Also acts as a dedecanoylase (By similarity). Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac) (By similarity). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression (By similarity). H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts as a transcription repressor (By similarity). Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells (By similarity). Also able to mediate deacetylation of histone H3 at 'Lys-36' (H3K36Ac) in the context of nucleosomes (By similarity). Also mediates deacetylation of non-histone proteins, such as ATM, CDK9, DDX21, DDB1, FBL, FKBP5/FKBP51, GABPB1, RAN, RRP9/U3-55K and POLR1E/PAF53 (By similarity). Enriched in nucleolus where it stimulates transcription activity of the RNA polymerase I complex (PubMed:16618798). Acts by mediating the deacetylation of the RNA polymerase I subunit POLR1E/PAF53, thereby promoting the association of RNA polymerase I with the rDNA promoter region and coding region (By similarity). In response to metabolic stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased RNA polymerase I transcription (By similarity). Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis (PubMed:16618798). Promotes pre-ribosomal RNA (pre-rRNA) cleavage at the 5'-terminal processing site by mediating deacetylation of RRP9/U3-55K, a core subunit of the U3 snoRNP complex (By similarity). Mediates 'Lys-37' deacetylation of Ran, thereby regulating the nuclear export of NF-kappa-B subunit RELA/p65 (PubMed:31075303). Acts as a regulator of DNA damage repair by mediating deacetylation of ATM during the late stages of DNA damage response, promoting ATM dephosphorylation and deactivation (By similarity). May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation (PubMed:18239138). Suppresses the activity of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes by mediating deacetylation of DDB1, which prevents the interaction between DDB1 and CUL4 (CUL4A or CUL4B) (By similarity). Activates RNA polymerase II transcription by mediating deacetylation of CDK9, thereby promoting 'Ser-2' phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (By similarity). Deacetylates FBL, promoting histone-glutamine methyltransferase activity of FBL (By similarity). Acts as a regulator of mitochondrial function by catalyzing deacetylation of GABPB1 (PubMed:25200183). Regulates Akt/AKT1 activity by mediating deacetylation of FKBP5/FKBP51 (By similarity). Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability by mediating deacetylation and subsequent activation of DDX21, thereby overcoming R-loop-mediated stalling of RNA polymerases (By similarity). In addition to protein deacetylase activity, also acts as protein-lysine deacylase (By similarity). Acts as a protein depropionylase by mediating depropionylation of Osterix (SP7), thereby regulating bone formation by osteoblasts (PubMed:30026585). Acts as a histone deglutarylase by mediating deglutarylation of histone H4 on 'Lys-91' (H4K91glu); a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (By similarity). Acts as a histone desuccinylase: in response to DNA damage, recruited to DNA double-strand breaks (DSBs) and catalyzes desuccinylation of histone H3 on 'Lys-122' (H3K122succ), thereby promoting chromatin condensation and DSB repair (By similarity). Also promotes DSB repair by promoting H3K18Ac deacetylation, regulating non-homologous end joining (NHEJ) (PubMed:27225932). Along with its role in DNA repair, required for chromosome synapsis during prophase I of female meiosis by catalyzing H3K18Ac deacetylation (PubMed:31256246). Involved in transcriptional repression of LINE-1 retrotransposon via H3K18Ac deacetylation, and promotes their association with the nuclear lamina (PubMed:31226208). Required to stabilize ribosomal DNA (rDNA) heterochromatin and prevent cellular senescence induced by rDNA instability (PubMed:28842251). Acts as a negative regulator of SIRT1 by preventing autodeacetylation of SIRT1, restricting SIRT1 deacetylase activity (PubMed:28923965)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SIRT7 is a positive regulator of Pol I transcription and is required for cell viability in mammals., [RefSeq, PubMed]; SIRT7 remodels the cytoskeleton via RAC1 to enhance host resistance to Mycobacterium tuberculosis., [RefSeq, PubMed]; Sirt7 protects against vascular calcification via modulation of reactive oxygen species and senescence of vascular smooth muscle cells., [RefSeq, PubMed]; Suggest a critical role of Sirt7 in the regulation of stress responses and cell death in the heart. Enhanced p53 activation by lack of Sirt7-mediated deacetylation contributes to the heart phenotype of Sirt7 mutant mice., [RefSeq, PubMed]; Using Sirt7 knockout and overexpressing cells we demonstrate an anti-proliferative role of Sirt7. We also show that Sirt7 expression inversely correlates with the tumorigenic potential of several murine cell lines, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ABY7;Q6X7B7;Q8QZZ5", "ec_number_list": "2.4.2.-;2.3.1.-;2.3.1.286", "go_molecular_function": "GO:0036055 protein-succinyllysine desuccinylase activity;GO:0061697 protein-glutaryllysine deglutarylase activity;GO:0097372 histone H3K18 deacetylase activity, NAD-dependent;GO:0003682 chromatin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005731 nucleolus organizer region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:1901836 regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0061698 protein deglutarylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BKJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920G8-1", "uniprot_id": "MFRN1_MOUSE", "mass": 37510.0, "length": 338, "protein_name": "Mitoferrin-1", "gene_name": "Gm16867; Slc25a37", "organism": "Mouse", "refseq_name": "mitoferrin-1", "refseq_ac": "NP_080607", "gene_names_uniprotkb": "Gm16867; Slc25a37; Gm16867; Mfrn; Mscp", "gene_names_refseq": "1700020E22Rik; 4930513O14Rik; 4930526G11Rik; C330015G08Rik; Mfrn1; Mfrn; Mscp; Slc25a37; frascati; mitoferrin", "protein_names_uniprotkb": "Mitoferrin-1; Mitochondrial iron transporter 1; Mitochondrial solute carrier protein; Solute carrier family 25 member 37", "protein_names_refseq": "mitochondrial iron transporter 1; mitochondrial solute carrier protein; mitoferrin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67712)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11845285;16511496;19805291;21750661;24509859;31219806;31563673;32518166;34428180", "class_list": "", "function": "Erythroblasts generated from murine embryonic stem cells null for Mfrn (also known as Slc25a37) show maturation arrest with severely impaired incorporation of 55Fe into haem [mitoferrin], [RefSeq, PubMed]; Impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1(gt/gt) cells results in elevated IRP1 RNA-binding that attenuates ALAS2 mRNA translation and protoporphyrin accumulation Erratum:[J Biol Chem. 2014 May 16;289(20):13707], [RefSeq, PubMed]; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis., [UniProtKB, PubMed]; Mitoferrin-1 is required for brain energy metabolism and hippocampus-dependent memory., [RefSeq, PubMed]; The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C367;Q8CEJ7;Q91ZY0;Q9D2G3;Q9D547", "ec_number_list": "", "go_molecular_function": "GO:0015093 ferrous iron transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0046985 positive regulation of hemoglobin biosynthetic process;GO:0048250 iron import into the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q920G8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHX3-1", "uniprot_id": "IL21R_MOUSE", "mass": 58355.0, "length": 529, "protein_name": "Interleukin-21 receptor", "gene_name": "Il21r", "organism": "Mouse", "refseq_name": "interleukin-21 receptor precursor", "refseq_ac": "NP_068687", "gene_names_uniprotkb": "Il21r; Nilr", "gene_names_refseq": "Il21r; NILR", "protein_names_uniprotkb": "Interleukin-21 receptor; IL-21 receptor; IL-21R; LR-beta; Lymphocyte receptor beta; NR8; Novel cytokine receptor 8; Novel interleukin receptor", "protein_names_refseq": "IL-21 receptor; IL-21R; LR-beta; NR8; interleukin-21 receptor precursor; lymphocyte receptor beta; novel cytokine receptor 8; novel interleukin receptor", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); immunodeficiency 56 (Disease Ontology:DOID:0111982); common variable immunodeficiency (Disease Ontology:DOID:12177); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); multiple sclerosis (Disease Ontology:DOID:2377); atopic dermatitis (Disease Ontology:DOID:3310); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); B-cell lymphoma (Disease Ontology:DOID:707); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:60504); (R-MMU-9020958)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11016959;11081504;12093291;16075062;21750661;31219806;32152506", "class_list": "", "function": "The common gamma chain (gamma c) is a required signaling component and supports IL-21-induced cell proliferation via JAK3, [RefSeq, PubMed]; This is a receptor for interleukin-21., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 1, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESM1", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JHX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99L45-1", "uniprot_id": "IF2B_MOUSE", "mass": 38092.0, "length": 331, "protein_name": "Eukaryotic translation initiation factor 2 subunit 2", "gene_name": "Eif2s2", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 2 subunit 2", "refseq_ac": "NP_080306", "gene_names_uniprotkb": "Eif2s2", "gene_names_refseq": "2810026E11Rik; 38kDa; D2Ertd303e; EIF2B; EIF2; Eif2s2", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 2; Eukaryotic translation initiation factor 2 subunit beta; eIF2-beta", "protein_names_refseq": "eIF-2-beta; eIF2-beta; eukaryotic translation initiation factor 2 subunit 2; eukaryotic translation initiation factor 2 subunit beta; eukaryotic translation initiation factor 2, subunit 2 (beta, 38kDa)", "tax_id": 10090, "disease": "leukodystrophy (Disease Ontology:DOID:10579)", "pathway": " (mmu:67204); (R-MMU-156827); (R-MMU-381042); (R-MMU-382556); (R-MMU-72649); (R-MMU-72695); (R-MMU-72702); (R-MMU-72706); (R-MMU-72731); (R-MMU-9840373)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "16931514;17242355;21183079;21750661;22872234;25428506;26495903;28306143;30084848;31219806;34428180;36210013;37453647", "class_list": "", "function": "Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B., [UniProtKB, UniProtKB]; This study provides evidence that even a mild mutation in eIF2B, leading merely to a ~ 20% decrease in its enzymatic activity, is associated with mitochondrial malfunction caused by defective oxphos and with increased mitochondrial biogenesis compensating for energetic needs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSH6;Q9CT12", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0001701 in utero embryonic development;GO:0008584 male gonad development;GO:0006413 translational initiation;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q99L45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQY8-1", "uniprot_id": "HUS1_MOUSE", "mass": 31680.0, "length": 280, "protein_name": "Checkpoint protein HUS1", "gene_name": "Hus1", "organism": "Mouse", "refseq_name": "checkpoint protein HUS1 isoform 2", "refseq_ac": "NP_001290461", "gene_names_uniprotkb": "Hus1", "gene_names_refseq": "Hus1", "protein_names_uniprotkb": "Checkpoint protein HUS1; mHUS1", "protein_names_refseq": "Hus1 homolog; checkpoint protein HUS1 isoform 2; checkpoint protein HUS1", "tax_id": 10090, "disease": "", "pathway": " (mmu:15574); (R-MMU-176187); (R-MMU-5685938); (R-MMU-5693607); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "10395797;25915840;30084848;31219806;33137086;9878245", "class_list": "", "function": "Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase., [UniProtKB, UniProtKB]; In vivo miRNA knockout screening identifies miR-190b as a novel tumor suppressor. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a component of a cell cycle checkpoint complex that causes cell cycle arrest in response to bulky DNA lesions and DNA replication blockage. Together with the proteins Rad9 and Rad1, the encoded protein forms a heterotrimeric complex known as the 9-1-1 complex. Mice lacking the encoded protein develop spontaneous chromosomal abnormalities resulting in embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]; Whereas Hus1(neo/neo) and Atm(-/-) single mutant mice survived low-dose MMC similar to wild-type controls, Hus1(neo/neo)Atm(-/-) double mutants showed striking MMC hypersensitivity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70543;Q6P8H5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0035861 site of double-strand break", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0006468 protein phosphorylation;GO:0000723 telomere maintenance;GO:0006974 DNA damage response;GO:0009411 response to UV", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BQY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C547-1", "uniprot_id": "HTR5B_MOUSE", "mass": 224319.0, "length": 2070, "protein_name": "HEAT repeat-containing protein 5B", "gene_name": "Heatr5b", "organism": "Mouse", "refseq_name": "HEAT repeat-containing protein 5B", "refseq_ac": "NP_001074648", "gene_names_uniprotkb": "Heatr5b; Kiaa1414", "gene_names_refseq": "2010013B10Rik; A230048G03Rik; D330050P16Rik; Heatr5b; mKIAA1414", "protein_names_uniprotkb": "HEAT repeat-containing protein 5B", "protein_names_refseq": "HEAT repeat-containing protein 5B", "tax_id": 10090, "disease": "", "pathway": " (mmu:320473)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19892989;21750661;25428506;30084848;31219806;34428180;36210013;37828378", "class_list": "", "function": "Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPS4;Q5DTY0;Q5PRF1;Q8C6W1;Q8C773", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0008104 intracellular protein localization;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C547-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGK6-1", "uniprot_id": "IFNL3_MOUSE", "mass": 21664.0, "length": 193, "protein_name": "Interferon lambda-3", "gene_name": "Ifnl3", "organism": "Mouse", "refseq_name": "interferon lambda-3 precursor", "refseq_ac": "NP_796370", "gene_names_uniprotkb": "Ifnl3; Il28b; Il28", "gene_names_refseq": "IFL-1; IL-28B; INF-alpha; INF-lambda; If1ia2; Ifnl3; Il28b; Il28", "protein_names_uniprotkb": "Interferon lambda-3; IFN-lambda-3; IL-28B; Interleukin-28B", "protein_names_refseq": "IFN-lambda-3; interferon 1ia2; interferon alpha; interferon lambda-3 precursor; interleukin 28; interleukin-28B", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); dengue disease (Disease Ontology:DOID:12205); dengue hemorrhagic fever (Disease Ontology:DOID:12206); thrombocytopenia (Disease Ontology:DOID:1588); hepatitis C (Disease Ontology:DOID:1883); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); subacute sclerosing panencephalitis (Disease Ontology:DOID:8970)", "pathway": " (mmu:338374); (R-MMU-8854691)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12483210;15731279;15914836;16618774;18250457;20712453;21518880;24751921;30779550", "class_list": "", "function": "Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; IFN-lambda inhibits HBV replication and blocks replication of a subgenomic and a full-length genomic HCV replicon, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VK73", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity;GO:0032003 interleukin-28 receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0032002 interleukin-28 receptor complex", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0050778 positive regulation of immune response;GO:0007259 cell surface receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CGK6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K572-1", "uniprot_id": "HUS1B_MOUSE", "mass": 31251.0, "length": 276, "protein_name": "Checkpoint protein HUS1B", "gene_name": "Hus1b", "organism": "Mouse", "refseq_name": "checkpoint protein HUS1B", "refseq_ac": "NP_694712", "gene_names_uniprotkb": "Hus1b", "gene_names_refseq": "Hus1b", "protein_names_uniprotkb": "Checkpoint protein HUS1B; mHUS1B", "protein_names_refseq": "Hus1 checkpoint homolog b; Hus1 homolog b; checkpoint protein HUS1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:210554)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11944979;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0035861 site of double-strand break;GO:0030896 checkpoint clamp complex", "go_biological_process": "GO:0000723 telomere maintenance;GO:0000724 double-strand break repair via homologous recombination;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0006289 nucleotide-excision repair;GO:0033314 mitotic DNA replication checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K572-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3P6-1", "uniprot_id": "INT14_MOUSE", "mass": 57237.0, "length": 515, "protein_name": "Integrator complex subunit 14", "gene_name": "Ints14", "organism": "Mouse", "refseq_name": "integrator complex subunit 14 isoform 1", "refseq_ac": "NP_001071099", "gene_names_uniprotkb": "Ints14; Vwa9", "gene_names_refseq": "2010321M09Rik; Ints14; Vwa9", "protein_names_uniprotkb": "Integrator complex subunit 14; von Willebrand factor A domain-containing protein 9", "protein_names_refseq": "UPF0464 protein C15orf44 homolog; integrator complex subunit 14 isoform 1; von Willebrand factor A domain containing 9; von Willebrand factor A domain-containing protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:69882); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "25428506;25605945;31219806;34428180;35820727", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS14 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THM0;Q3V323;Q3V3E8;Q8C072", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R3P6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R412-1", "uniprot_id": "IF27A_MOUSE", "mass": 7929.0, "length": 90, "protein_name": "Interferon alpha-inducible protein 27-like protein 2A", "gene_name": "Ifi27l2a", "organism": "Mouse", "refseq_name": "interferon alpha-inducible protein 27-like protein 2A isoform 1 precursor", "refseq_ac": "NP_084079", "gene_names_uniprotkb": "Ifi27l2a; Ifi27; Isg12", "gene_names_refseq": "2310061N23Rik; Ifi27l2a; Ifi27; Isg12(b1); Isg12", "protein_names_uniprotkb": "Interferon alpha-inducible protein 27-like protein 2A; ISG12; Interferon-stimulated gene 12 protein", "protein_names_refseq": "interferon alpha-inducible protein 27-like protein 2A isoform 1 precursor; interferon alpha-inducible protein 27-like protein 2A; interferon stimulated gene 12(b1); interferon-stimulated gene 12 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:76933)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12388728;14728724;17704618;18948406;22427340;26699642", "class_list": "", "function": "Collectively, these findings suggest that Ifi27l2a has an antiviral phenotype in subsets of cells and that at least some interferon-stimulated genes have specific inhibitory functions in restricted tissues in West Nile virus infection. Publication Status: Online-Only, [RefSeq, PubMed]; ISG12b is an additional candidate for a adipocytokine induced to express in adipose tissue by interferon, [RefSeq, PubMed]; Identify a feedback loop activated by interferons via interferon stimulated gene 12 that inhibits the vasculoprotective functions of NR4A1 nuclear receptors., [RefSeq, PubMed]; Induced by Sindbis virus encephalitis to greater levels in brains of weanling mice than neonatal mice and significantly delayed death in the neonatal mice (interferon- inducible protective protein, ISG12)., [RefSeq, PubMed]; May be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). Through the regulation of NR4A1 transcriptional activity, may play a role in the vascular response to injury (PubMed:22427340)., [UniProtKB, PubMed]; Mitochondrial-localized ISG12b1 protein inhibits adipocyte differentiation and mitochondrial biogenesis and function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0009615 response to virus;GO:0097193 intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R412-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R460-1", "uniprot_id": "IL36G_MOUSE", "mass": 18733.0, "length": 164, "protein_name": "Interleukin-36 gamma", "gene_name": "Il36g", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Il36g; Il1f9", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-36 gamma; IL-1F9; Interleukin-1 family member 9", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-9014826)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11991723;21860022;21965679", "class_list": "", "function": "Functions as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. May play a role in pro-inflammatory responses during particular neutrophilic airway inflammation. May be involved in the innate immune response to fungal pathogens. Induces the production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF and IL-23. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14BB6", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0045087 innate immune response;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R460-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4K2-1", "uniprot_id": "IRAK4_MOUSE", "mass": 50872.0, "length": 459, "protein_name": "Interleukin-1 receptor-associated kinase 4", "gene_name": "Irak4", "organism": "Mouse", "refseq_name": "interleukin-1 receptor-associated kinase 4", "refseq_ac": "NP_084202", "gene_names_uniprotkb": "Irak4", "gene_names_refseq": "8430405M07Rik; 9330209D03Rik; IRAK-4; Irak4; NY-REN-64", "protein_names_uniprotkb": "Interleukin-1 receptor-associated kinase 4; 2.7.11.1; IRAK-4", "protein_names_refseq": "interleukin-1 receptor-associated kinase 4", "tax_id": 10090, "disease": "maxillary sinusitis (Disease Ontology:DOID:2051); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); allergic rhinitis (Disease Ontology:DOID:4481); primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (mmu:266632); (R-MMU-1257604); (R-MMU-6811558); (R-MMU-9020702)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "11923871;11960013;12538665;12682231;16177054;16951688;21396111;25428506;26621451;30076215;30084848;31219806;33573200;35339728", "class_list": "", "function": "Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion., [RefSeq, PubMed]; Irak4 is required for the majority of IL-18-mediated functions both in vitro and in vivo; Th1 cells lacking Irak4 fail to produce IFN-gamma and undergo proliferation in response to IL-18., [RefSeq, PubMed]; MyD88s acts as a negative regulator of IL-1R/TLR/MyD88-triggered signals, leading to a transcriptionally controlled negative regulation of innate immune responses., [RefSeq, PubMed]; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections (By similarity)., [UniProtKB]; Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. (IRAK4), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80WW1", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;3.2.1.31;2.7.12.1;2.7.11.22;2.7.1.153;2.7.1.137;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.10.1;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.2.2.6;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;3.1.3.48;2.7.1.40;2.7.11.21;2.3.2.23;3.6.5.2;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.3.2.27;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0035556 intracellular signal transduction;GO:0045087 innate immune response;GO:0002446 neutrophil mediated immunity;GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8R4K2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC12-1", "uniprot_id": "HUTU_MOUSE", "mass": 74590.0, "length": 676, "protein_name": "Urocanate hydratase", "gene_name": "Uroc1", "organism": "Mouse", "refseq_name": "urocanate hydratase isoform 2", "refseq_ac": "NP_659189", "gene_names_uniprotkb": "Uroc1", "gene_names_refseq": "Uroc1", "protein_names_uniprotkb": "Urocanate hydratase; 4.2.1.49; Imidazolonepropionate hydrolase; Urocanase", "protein_names_refseq": "imidazolonepropionate hydrolase; urocanate hydratase isoform 2; urocanate hydratase", "tax_id": 10090, "disease": "urocanase deficiency (Disease Ontology:DOID:0112180)", "pathway": " (mmu:243537); (R-MMU-70921)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "23806337;25428506;34428180;36064721;37453647", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QNN2", "ec_number_list": "4.2.1.49", "go_molecular_function": "GO:0016153 urocanate hydratase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0019557 L-histidine catabolic process to glutamate and formate;GO:0006548 L-histidine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VC12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHP7-1", "uniprot_id": "ILEUB_MOUSE", "mass": 42887.0, "length": 382, "protein_name": "Leukocyte elastase inhibitor B", "gene_name": "Serpinb1b", "organism": "Mouse", "refseq_name": "leukocyte elastase inhibitor B", "refseq_ac": "NP_766640", "gene_names_uniprotkb": "Serpinb1b", "gene_names_refseq": "6330533H24Rik; EIB; Serpin1b1; Serpinb1b; ovalbumin", "protein_names_uniprotkb": "Leukocyte elastase inhibitor B; Serine protease inhibitor EIB; Serpin B1b", "protein_names_refseq": "leukocyte elastase inhibitor B; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1b; serine protease inhibitor EIB; serpin B1b", "tax_id": 10090, "disease": "alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (mmu:282663)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11863365;12189154;27802388;30692621", "class_list": "", "function": "CDNA cloning, gene structure and biological characterization homologous to human MNEI, [RefSeq, PubMed]; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G (PubMed:12189154). During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0030336 negative regulation of cell migration;GO:0032691 negative regulation of interleukin-1 beta production;GO:0010951 negative regulation of endopeptidase activity;GO:0044342 type B pancreatic cell proliferation;GO:0042176 regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VHP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J55-1", "uniprot_id": "IER5L_MOUSE", "mass": 42530.0, "length": 406, "protein_name": "Immediate early response gene 5-like protein", "gene_name": "Ier5l", "organism": "Mouse", "refseq_name": "immediate early response gene 5-like protein", "refseq_ac": "NP_084520", "gene_names_uniprotkb": "Ier5l", "gene_names_refseq": "2610524G09Rik; Ier5l", "protein_names_uniprotkb": "Immediate early response gene 5-like protein", "protein_names_refseq": "immediate early response gene 5-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:72500)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTA0;Q8CC26", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99J55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPN8-1", "uniprot_id": "IF2B3_MOUSE", "mass": 63575.0, "length": 579, "protein_name": "Insulin-like growth factor 2 mRNA-binding protein 3", "gene_name": "Igf2bp3", "organism": "Mouse", "refseq_name": "insulin-like growth factor 2 mRNA-binding protein 3", "refseq_ac": "NP_076159", "gene_names_uniprotkb": "Igf2bp3; Vickz3", "gene_names_refseq": "2610101N11Rik; IMP-3; IMP3; Igf2bp3; Koc13; Neilsen; mimp3", "protein_names_uniprotkb": "Insulin-like growth factor 2 mRNA-binding protein 3; IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; VICKZ family member 3; mIMP-3", "protein_names_refseq": "IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; VICKZ family member 3; insulin-like growth factor 2 mRNA-binding protein 3; insulin-like growth factor 2, binding protein 3; mIMP-3", "tax_id": 10090, "disease": "acquired metabolic disease (Disease Ontology:DOID:0060158)", "pathway": " (mmu:140488)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10525192;10875929;11288142;12161597;12921532;15345747;15601260;15753088;16049158;19131326;21183079;23388827;25428506;30084848;31219806;34887587;38353724;39443946;9891060", "class_list": "", "function": "LINC00942 inhibits ferroptosis and induces the immunosuppression of regulatory T cells by recruiting IGF2BP3/SLC7A11 in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; M6A-modified exosome-derived circHIF1alpha binding to KH domain of IGF2BP3 mediates DNA damage and arrests G1/S transition phase to resists bacterial infection in bacteremia. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation (By similarity). Binds to beta-actin/ACTB and MYC transcripts (By similarity). Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHZ6;Q8C2J9", "ec_number_list": "", "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0048027 mRNA 5'-UTR binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:0006417 regulation of translation;GO:0007399 nervous system development;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9CPN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D103-1", "uniprot_id": "IFM1_MOUSE", "mass": 11524.0, "length": 106, "protein_name": "Interferon-induced transmembrane protein 1", "gene_name": "Ifitm1", "organism": "Mouse", "refseq_name": "interferon-induced transmembrane protein 1 isoform a", "refseq_ac": "NP_001106186", "gene_names_uniprotkb": "Ifitm1", "gene_names_refseq": "1110036C17Rik; DSPA2a; Ifitm1; Mil-2; Mil2", "protein_names_uniprotkb": "Interferon-induced transmembrane protein 1; DSPA2a; Dispanin subfamily A member 2a; Fragilis protein 2; Mil-2; Mouse ifitm-like protein 2", "protein_names_refseq": "dispanin subfamily A member 2a; fragilis protein 2; fragilis2; ifitm-like protein 2; interferon induced transmembrane protein 2 like; interferon-induced transmembrane protein 1 isoform a", "tax_id": 10090, "disease": "COVID-19 (Disease Ontology:DOID:0080600); gallbladder adenocarcinoma (Disease Ontology:DOID:3500); adenosquamous gallbladder carcinoma (Disease Ontology:DOID:5627)", "pathway": " (mmu:68713); (R-MMU-198933)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12659663;14516695;15857914;16326387;16847454;18505827;21166591;21253575;22363774;27802388;33597502;35820727", "class_list": "", "function": "Fragilis2 regulates epithelialization of the somites and paraxial mesoderm formation., [RefSeq, PubMed]; IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation., [UniProtKB, PubMed, PubMed]; The antiproliferative action of IFN-gamma requires the induction of IFITM1., [RefSeq, PubMed]; The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2S7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0051607 defense response to virus;GO:0030336 negative regulation of cell migration;GO:0045071 negative regulation of viral genome replication;GO:0060337 type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D103-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D154-1", "uniprot_id": "ILEUA_MOUSE", "mass": 42575.0, "length": 379, "protein_name": "Leukocyte elastase inhibitor A", "gene_name": "Serpinb1a", "organism": "Mouse", "refseq_name": "leukocyte elastase inhibitor A", "refseq_ac": "NP_079705", "gene_names_uniprotkb": "Serpinb1a; Serpinb1", "gene_names_refseq": "1190005M04Rik; EIA; EI; ELANH2; LEI; M/NEI; MNEI; PI2; Serpinb1a", "protein_names_uniprotkb": "Leukocyte elastase inhibitor A; Serine protease inhibitor EIA; Serpin B1a", "protein_names_refseq": "leukocyte elastase inhibitor A; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1a; serine (or cysteine) proteinase inhibitor, clade B, member 1a; serine protease inhibitor EIA; serpin B1a", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (mmu:66222); (R-MMU-6798695); (R-MMU-9948001)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "11863365;12189154;17664292;21248149;21683252;21750661;26701651;26740625;30084848;30692621;31219806;32152506;33262755;34428180;35984892;37507081", "class_list": "", "function": "Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:17664292, PubMed:21248149, PubMed:21683252, PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection (PubMed:17664292). These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also acts as a potent intracellular inhibitor of granzyme H (PubMed:12189154). During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). In addition, promotes the proliferation of beta-cells when secreted (PubMed:26701651)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Serpinb1a Is Dispensable for the Development and Cytokine Response of Invariant Natural Killer T Cell Subsets. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV23;Q5SUV7;Q9D0S8;Q9D7S8", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005769 early endosome;GO:0031012 extracellular matrix;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0006954 inflammatory response;GO:0019725 cellular homeostasis;GO:0030336 negative regulation of cell migration;GO:0032691 negative regulation of interleukin-1 beta production;GO:0010951 negative regulation of endopeptidase activity", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9D154-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6Z6-1", "uniprot_id": "IL36B_MOUSE", "mass": 20878.0, "length": 183, "protein_name": "Interleukin-36 beta", "gene_name": "Il36b", "organism": "Mouse", "refseq_name": "interleukin-36 beta", "refseq_ac": "NP_081439", "gene_names_uniprotkb": "Il36b; Fil1e; Il1f8", "gene_names_refseq": "2310043N20Rik; If36b; Il1f8; Il36b", "protein_names_uniprotkb": "Interleukin-36 beta; IL-1F8; Interleukin-1 family member 8", "protein_names_refseq": "IL-1F8; interleukin 1 family, member 8; interleukin-36 beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:69677); (R-MMU-9014826)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11991723;15749024;19717513;21860022;21965679;31684829;32421784;35436743", "class_list": "", "function": "A critical role of IL-36R ligands in the interface between innate and adaptive immunity, leading to the stimulation of T helper responses., [RefSeq, PubMed]; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T-helper 1 (Th1) cells, cultured CD4(+) T-cells and splenocytes., [UniProtKB, UniProtKB, PubMed, PubMed]; Effect of Interleukin-36beta on Activating Autophagy of CD4+CD25+ Regulatory T cells and Its Immune Regulation in Sepsis., [RefSeq, PubMed]; Interleukin 36beta may enhance antitumor immune response of CD8(+)T cells by regulating GM16343., [RefSeq, PubMed]; Interleukin-36beta exacerbates DSS-induce acute colitis via inhibiting Foxp3(+) regulatory T cell response and increasing Th2 cell response., [RefSeq, PubMed]; The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce any of the classical IL-1 responses in glial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R461", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0045087 innate immune response;GO:0032755 positive regulation of interleukin-6 production;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D6Z6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8Y8-1", "uniprot_id": "ING5_MOUSE", "mass": 27799.0, "length": 240, "protein_name": "Inhibitor of growth protein 5", "gene_name": "Ing5", "organism": "Mouse", "refseq_name": "inhibitor of growth protein 5", "refseq_ac": "NP_079730", "gene_names_uniprotkb": "Ing5", "gene_names_refseq": "1700001C14Rik; 1700027H23Rik; 1810018M11Rik; Ing5", "protein_names_uniprotkb": "Inhibitor of growth protein 5", "protein_names_refseq": "inhibitor of growth protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:66262); (R-MMU-3214847); (R-MMU-6804758)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "19144319;21183079;21750661;31838455;34428180;37275850;38446206", "class_list": "", "function": "Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner., [UniProtKB, UniProtKB]; Expression analysis of microRNAs and mRNAs in myofibroblast differentiation of lung resident mesenchymal stem cells., [RefSeq, PubMed]; ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development., [RefSeq, PubMed]; The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UL57;Q6P292;Q9CV64;Q9D9V8", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000123 histone acetyltransferase complex;GO:0070776 MOZ/MORF histone acetyltransferase complex", "go_biological_process": "GO:0050793 regulation of developmental process;GO:2000278 regulation of DNA biosynthetic process;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D8Y8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBB5-1", "uniprot_id": "IF4E3_MOUSE", "mass": 22836.0, "length": 207, "protein_name": "Eukaryotic translation initiation factor 4E type 3", "gene_name": "Eif4e3", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 4E type 3", "refseq_ac": "NP_080105", "gene_names_uniprotkb": "Eif4e3", "gene_names_refseq": "1300018P11Rik; Eif4e3; eIF4E-3", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E type 3; eIF-4E type 3; eIF-4E3; eIF4E type 3; eIF4E-3", "protein_names_refseq": "eIF-4E type 3; eIF-4E3; eIF4E type 3; eukaryotic translation initiation factor 4E type 3; eukaryotic translation initiation factor-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66892); (R-MMU-1169408)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15153109;22872234;23431134;31599954;34428180", "class_list": "", "function": "EIF4E3 specifically binds the m(7)G cap in the absence of an aromatic sandwich, using instead a different spatial arrangement of residues to provide the necessary electrostatic and van der Waals contacts., [RefSeq, PubMed]; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D983", "ec_number_list": "", "go_molecular_function": "GO:0000340 RNA 7-methylguanosine cap binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0016281 eukaryotic translation initiation factor 4F complex", "go_biological_process": "GO:0006417 regulation of translation;GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DBB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQK7-1", "uniprot_id": "ICMT_MOUSE", "mass": 31790.0, "length": 283, "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "Icmt", "organism": "Mouse", "refseq_name": "protein-S-isoprenylcysteine O-methyltransferase", "refseq_ac": "NP_598549", "gene_names_uniprotkb": "Icmt", "gene_names_refseq": "1700008E11Rik; Gm13095; HSTE14; Icmt; PPMT; STE14; pcCMT", "protein_names_uniprotkb": "Protein-S-isoprenylcysteine O-methyltransferase; 2.1.1.100; Isoprenylcysteine carboxylmethyltransferase; PPMT; Prenylated protein carboxyl methyltransferase; Prenylcysteine carboxyl methyltransferase; pcCMT", "protein_names_refseq": "prenylated protein carboxyl methyltransferase; prenylcysteine carboxyl methyltransferase; protein-S-isoprenylcysteine O-methyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:57295); (R-MMU-163841); (R-MMU-9648002)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10649571;17652517;25428507;31219806;32422978;35171349", "class_list": "", "function": "Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues., [UniProtKB, PubMed]; Isoprenylcysteine Carboxyl Methyltransferase and Its Substrate Ras Are Critical Players Regulating TLR-Mediated Inflammatory Responses. Publication Status: Online-Only, [RefSeq, PubMed]; Isoprenylcysteine carboxyl methyltransferase is critical for glioblastoma growth and survival by activating Ras/Raf/Mek/Erk., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;2.1.1.100", "go_molecular_function": "GO:0008140 cAMP response element binding protein binding;GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0008284 positive regulation of cell population proliferation;GO:0050905 neuromuscular process;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EQK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERS6-1", "uniprot_id": "IRPL2_MOUSE", "mass": 78798.0, "length": 686, "protein_name": "X-linked interleukin-1 receptor accessory protein-like 2", "gene_name": "Il1rapl2", "organism": "Mouse", "refseq_name": "X-linked interleukin-1 receptor accessory protein-like 2 precursor", "refseq_ac": "NP_109613", "gene_names_uniprotkb": "Il1rapl2", "gene_names_refseq": "Il1rapl2", "protein_names_uniprotkb": "X-linked interleukin-1 receptor accessory protein-like 2; 3.2.2.6; IL-1 receptor accessory protein-like 2; IL-1-RAPL-2; IL-1RAPL-2; IL1RAPL-2-related protein; IL1RAPL-2; TIGIRR-1; Three immunoglobulin domain-containing IL-1 receptor-related 1", "protein_names_refseq": "IL-1 receptor accessory protein-like 2; IL-1-RAPL-2; IL-1RAPL-2; IL1RAPL-2-related protein; IL1RAPL-2; TIGIRR-1; X-linked interleukin-1 receptor accessory protein-like 2 precursor; X-linked interleukin-1 receptor accessory protein-like 2; three immunoglobulin domain-containing IL-1 receptor-related 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:60367); (R-MMU-388844)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10882729;11587848;25428506", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9ER66", "ec_number_list": "3.2.2.5;2.4.2.31;3.2.2.6;2.4.99.20;3.2.2.-;3.1.3.48", "go_molecular_function": "GO:0004910 interleukin-1, type II, blocking receptor activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007399 nervous system development;GO:1905606 regulation of presynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ERS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJY8-1", "uniprot_id": "IL22B_MOUSE", "mass": 20179.0, "length": 179, "protein_name": "Interleukin-22b", "gene_name": "Il22b", "organism": "Mouse", "refseq_name": "interleukin-22b precursor", "refseq_ac": "NP_473420", "gene_names_uniprotkb": "Il22b; Iltifb", "gene_names_refseq": "IL-22b; IL-TIFb; If2b2; Il22b; Iltifb", "protein_names_uniprotkb": "Interleukin-22b; IL-10-related T-cell-derived-inducible factor beta; IL-22b; IL-TIF beta; IL-TIFb", "protein_names_refseq": "IL-10-related T-cell-derived-inducible factor beta; IL-TIF beta; interferon 2b2; interleukin 10-related T cell-derived inducible factor beta; interleukin-22b precursor", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); tuberculosis (Disease Ontology:DOID:399); rhinitis (Disease Ontology:DOID:4483); myocarditis (Disease Ontology:DOID:820)", "pathway": " (mmu:116849)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10657629;11197690", "class_list": "", "function": "Cytokine that contributes to the inflammatory response in vivo., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QAL9", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0043235 receptor complex;GO:0140368 decoy receptor complex", "go_biological_process": "GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKV9-1", "uniprot_id": "IL20_MOUSE", "mass": 20098.0, "length": 176, "protein_name": "Interleukin-20", "gene_name": "Il20", "organism": "Mouse", "refseq_name": "interleukin-20 isoform 2", "refseq_ac": "NP_001298020", "gene_names_uniprotkb": "Il20; Zcyto10", "gene_names_refseq": "If2d; Il20; Zcyto10", "protein_names_uniprotkb": "Interleukin-20; Cytokine Zcyto10; IL-20", "protein_names_refseq": "IL-20; cytokine Zcyto10; four alpha helix cytokine ZCYTO10; four helix bundle cytokine 10; interferon 2d; interleukin-20 isoform 2", "tax_id": 10090, "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (mmu:58181); (R-MMU-8854691)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11163236;16778121;17878297;23793061;35486004;35613844;37884352", "class_list": "", "function": "IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling. Publication Status: Online-Only, [RefSeq, PubMed]; IL-20 is a proatherogenic cytokine that contributes to the progression of atherosclerosis., [RefSeq, PubMed]; IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs, [RefSeq, PubMed]; IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis., [RefSeq, PubMed]; IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis., [RefSeq, PubMed]; Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation (PubMed:23793061). Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity. Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration. Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB. Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB (By similarity). Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2 (PubMed:17878297). Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045517 interleukin-20 receptor binding;GO:0045518 interleukin-22 receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030876 interleukin-20 receptor complex", "go_biological_process": "GO:0006955 immune response;GO:0030097 hemopoiesis;GO:0045672 positive regulation of osteoclast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JKV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLA2-1", "uniprot_id": "IL36A_MOUSE", "mass": 18015.0, "length": 160, "protein_name": "Interleukin-36 alpha", "gene_name": "Il36a", "organism": "Mouse", "refseq_name": "interleukin-36 alpha", "refseq_ac": "NP_062323", "gene_names_uniprotkb": "Il36a; Fil1e; Il1e; Il1f6; Il1h1", "gene_names_refseq": "Fil1; IL-1H1; IL1RP2; If36a; Il1f6; Il1f9; Il36a", "protein_names_uniprotkb": "Interleukin-36 alpha; FIL1 epsilon; IL-1 epsilon; IL-1F6; IL-1H1; Interleukin-1 epsilon; Interleukin-1 family member 6; Interleukin-1 homolog 1", "protein_names_refseq": "FIL1 epsilon; Fil1epsilon; IL-1 epsilon; IL-1F6; interleukin 1 family, member 6 (epsilon); interleukin 1 family, member 9; interleukin-1 epsilon; interleukin-1 family member 6; interleukin-1 homolog 1; interleukin-36 alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:54448); (R-MMU-9014826)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10744718;11466363;20101239;21860022;21881584;21965679;23029241;24829417;33645549;34555640;34686582;34697411;38412100", "class_list": "", "function": "Analysis of Il36a induction by C/EBPbeta via a half-CRE*C/EBP element in murine macrophages in dependence of its CpG methylation level., [RefSeq, PubMed]; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of pro-inflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes. May play a role in pro-inflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c(+) alveolar macrophages. May be involved in T-cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c(+) cells. May be involved in CD4(+) T-cell proliferation. Induces NF-kappa B activation in macrophages., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease., [RefSeq, PubMed]; IL-36alpha Enhances Host Defense against Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas., [RefSeq, PubMed]; IL-37 dampens immunosuppressive functions of MDSCs via metabolic reprogramming in the tumor microenvironment., [RefSeq, PubMed]; Interleukin-36alpha inhibits colorectal cancer metastasis by enhancing the infiltration and activity of CD8(+) T lymphocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0043235 receptor complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0045087 innate immune response;GO:0032755 positive regulation of interleukin-6 production;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JLA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXT6-1", "uniprot_id": "IL17B_MOUSE", "mass": 20309.0, "length": 180, "protein_name": "Interleukin-17B", "gene_name": "Il17b", "organism": "Mouse", "refseq_name": "interleukin-17B precursor", "refseq_ac": "NP_062381", "gene_names_uniprotkb": "Il17b; Nirf; Zcyto7", "gene_names_refseq": "1110006O16Rik; 1700006N07Rik; Il17b; Zcyto7", "protein_names_uniprotkb": "Interleukin-17B; Cytokine CX1; Cytokine-like protein ZCYTO7; IL-17B; Neuronal interleukin-17-related factor", "protein_names_refseq": "IL-17B; cytokine CX1; cytokine-like protein ZCYTO7; gene for cytokine-like protein; interleukin-17B precursor; neuronal interleukin-17-related factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:56069)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15596145;16698929;21750661;25428506;31219806;36046722;39115936", "class_list": "", "function": "Expressed in the mouse embryonic limb buds and may play a role in chondrogenesis and osteogenesis, [RefSeq, PubMed]; IL-17B alleviates the pathogenesis of systemic lupus erythematosus by inhibiting FASN-mediated differentiation of B cells. Publication Status: Online-Only, [RefSeq, PubMed]; Necroptosis Plays a Crucial Role in Vascular Injury during DVT and Is Enhanced by IL-17B. Publication Status: Online-Only, [RefSeq, PubMed]; Socs3 is an essential negative regulator of IL-23 signaling, inhibition of which constrains the generation of IL-17-secreting T-cell differentiation, [RefSeq, PubMed]; Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99MY3;Q9CTI4", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0030593 neutrophil chemotaxis;GO:1900017 positive regulation of cytokine production involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QXT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QY05-1", "uniprot_id": "INSL6_MOUSE", "mass": 22215.0, "length": 191, "protein_name": "Insulin-like peptide INSL6", "gene_name": "Insl6", "organism": "Mouse", "refseq_name": "insulin-like peptide INSL6 precursor", "refseq_ac": "NP_038782", "gene_names_uniprotkb": "Insl6", "gene_names_refseq": "Insl6; RIF1", "protein_names_uniprotkb": "Insulin-like peptide INSL6; Insulin-like peptide 6", "protein_names_refseq": "insulin-like peptide 6; insulin-like peptide INSL6 precursor; insulin-like peptide INSL6; relaxin/insulin-like factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27356)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10614671;15804440;17971504;19520787;20807758;29887522;34585777", "class_list": "", "function": "Data indicate that Insl6 is an injury-regulated myokine that functions as a myogenic regenerative factor., [RefSeq, PubMed]; Endogenous Insl6 protein inhibits cardiac systolic dysfunction and cardiac fibrosis in angiotensin II- and isoproterenol-induced cardiac stress models. Publication Status: Online-Only, [RefSeq, PubMed]; Insl6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; May have a role in sperm development and fertilization., [UniProtKB]; Results suggest that INSL6 modulates two different processes related to fertility, spermatogenesis, and sperm motility., [RefSeq, PubMed]; TNF-Polarized Macrophages Produce Insulin-like 6 Peptide to Stimulate Bone Formation in Rheumatoid Arthritis in Mice., [RefSeq, PubMed]; The presence of immunoreactive INSL6 in discrete populations of hypothalamic and brainstem neurons and in Leydig cells of the testis suggests a diverse biological function of this novel peptide., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0043066 negative regulation of apoptotic process;GO:0030317 flagellated sperm motility;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QY05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0N2-1", "uniprot_id": "IF2H_MOUSE", "mass": 51131.0, "length": 472, "protein_name": "Eukaryotic translation initiation factor 2 subunit 3, Y-linked", "gene_name": "Eif2s3y", "organism": "Mouse", "refseq_name": "eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform 1", "refseq_ac": "NP_036141", "gene_names_uniprotkb": "Eif2s3y", "gene_names_refseq": "Eif-2gy; Eif2s3y; Spy; Tfy", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 3, Y-linked; 3.6.5.3; Eukaryotic translation initiation factor 2 subunit gamma, Y-linked; Spermatogonial proliferation factor; Spy; eIF-2-gamma Y", "protein_names_refseq": "eIF-2-gamma Y; eukaryotic translation initiation factor 2 subunit 3, Y-linked isoform 1; eukaryotic translation initiation factor 2 subunit 3, Y-linked; eukaryotic translation initiation factor 2 subunit gamma, Y-linked; spermatogenesis Y; spermatogonial proliferation factor", "tax_id": 10090, "disease": "MEHMO syndrome (Disease Ontology:DOID:0060801); leukodystrophy (Disease Ontology:DOID:10579); glucose metabolism disease (Disease Ontology:DOID:4194); hypopituitarism (Disease Ontology:DOID:9406)", "pathway": " (mmu:26908)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11528390;12023983;16325480;25579647;26495903;26823431;28011936;34428180;34727865;35984892;37586163;40997131;9736774", "class_list": "", "function": "Eif2s3y alleviated LPS-induced damage to mouse testis and maintained spermatogenesis by negatively regulating Adamts5., [RefSeq, PubMed]; Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). Along with its paralog on chromosome X, may contribute to spermatogenesis up to the round spermatid stage (PubMed:11528390, PubMed:25579647, PubMed:26823431)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; The Role of Eif2s3y in Mouse Spermatogenesis and ESC., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;4.2.99.18;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0000049 tRNA binding;GO:0008135 translation factor activity, RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0002183 cytoplasmic translational initiation;GO:0007283 spermatogenesis;GO:0006413 translational initiation;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z0N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2TB02-1", "uniprot_id": "IKBD_MOUSE", "mass": 34942.0, "length": 327, "protein_name": "NF-kappa-B inhibitor delta", "gene_name": "Nfkbid", "organism": "Mouse", "refseq_name": "NF-kappa-B inhibitor delta isoform 2", "refseq_ac": "NP_742154", "gene_names_uniprotkb": "Nfkbid; Ikbns", "gene_names_refseq": "I-kappa-B-delta; IkappaBNS; Nfkbid; ikB-delta", "protein_names_uniprotkb": "NF-kappa-B inhibitor delta; I-kappa-B-delta; IkB-delta; IkappaBNS; IkappaBdelta", "protein_names_refseq": "NF-kappa-B inhibitor delta isoform 2; NF-kappa-B inhibitor delta", "tax_id": 10090, "disease": "", "pathway": " (mmu:243910)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11931770;15749903;16410444;16413922;17641034;21750661;25282160;25428506;34428180", "class_list": "", "function": "Blocks transcription from NF-kappa B reporters, alters NF-kappa B electrophoretic mobility shifts, and interacts with NF-kappa B proteins in thymic nuclear lysates following TCR stimulation., [RefSeq, PubMed]; IkappaBNS regulates inflammatory responses by inhibiting the induction of a subset of TLR-dependent genes through modulation of NF-kappaB activity., [RefSeq, PubMed]; IkappaBNS regulates production of interleukin (IL)-2 and other cytokines induced via T-cell receptor ligation., [RefSeq, PubMed]; Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses (PubMed:11931770, PubMed:15749903, PubMed:16410444, PubMed:16413922, PubMed:17641034). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (PubMed:25282160). According to PubMed:11931770, it may also regulate TCR-induced negative selection of thymocytes (PubMed:11931770)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJP0;Q8CIW1", "ec_number_list": "", "go_molecular_function": "GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:2000321 positive regulation of T-helper 17 cell differentiation;GO:0006954 inflammatory response;GO:0050852 T cell receptor signaling pathway;GO:0070245 positive regulation of thymocyte apoptotic process;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q2TB02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01878-1", "uniprot_id": "IGHA_MOUSE", "mass": 36876.0, "length": 344, "protein_name": "Ig alpha chain C region", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig alpha chain C region", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "115869;17330941;29187734;34428180;6776528;6790349", "class_list": "", "function": "Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0042571 immunoglobulin complex, circulating", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P01878-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18893-1", "uniprot_id": "IL10_MOUSE", "mass": 20641.0, "length": 178, "protein_name": "Interleukin-10", "gene_name": "Il10", "organism": "Mouse", "refseq_name": "interleukin-10 precursor", "refseq_ac": "NP_034678", "gene_names_uniprotkb": "Il10; Il-10", "gene_names_refseq": "CSIF; If2a; Il-10; Il10", "protein_names_uniprotkb": "Interleukin-10; CSIF; Cytokine synthesis inhibitory factor; IL-10", "protein_names_refseq": "cytokine synthesis inhibitory factor; interferon 2a; interleukin-10 precursor", "tax_id": 10090, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); inflammatory bowel disease (Disease Ontology:DOID:0050589); obstructive sleep apnea (Disease Ontology:DOID:0050848); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); ocular tuberculosis (Disease Ontology:DOID:0070344); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); COVID-19 (Disease Ontology:DOID:0080600); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); dry eye syndrome (Disease Ontology:DOID:10140); bacterial infectious disease (Disease Ontology:DOID:104); common cold (Disease Ontology:DOID:10459); stomach cancer (Disease Ontology:DOID:10534); celiac disease (Disease Ontology:DOID:10608); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); anogenital venereal wart (Disease Ontology:DOID:11168); allergic conjunctivitis (Disease Ontology:DOID:11204); disseminated intravascular coagulation (Disease Ontology:DOID:11247); trachoma (Disease Ontology:DOID:11265); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); gestational diabetes (Disease Ontology:DOID:11714); pericardial effusion (Disease Ontology:DOID:118); panuveitis (Disease Ontology:DOID:12030); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); factor VIII deficiency (Disease Ontology:DOID:12134); primary biliary cholangitis (Disease Ontology:DOID:12236); Graves' disease (Disease Ontology:DOID:12361); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); intermediate uveitis (Disease Ontology:DOID:12732); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); Fanconi anemia (Disease Ontology:DOID:13636); endometrial cancer (Disease Ontology:DOID:1380); toxic shock syndrome (Disease Ontology:DOID:14115); choroid disease (Disease Ontology:DOID:1417); hypothyroidism (Disease Ontology:DOID:1459); prostatitis (Disease Ontology:DOID:14654); major depressive disorder (Disease Ontology:DOID:1470); aggressive periodontitis (Disease Ontology:DOID:1474); alcohol use disorder (Disease Ontology:DOID:1574); diffuse scleroderma (Disease Ontology:DOID:1580); thrombocytopenia (Disease Ontology:DOID:1588); mitral valve stenosis (Disease Ontology:DOID:1754); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); anemia (Disease Ontology:DOID:2355); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); glucosephosphate dehydrogenase deficiency (Disease Ontology:DOID:2862); endometriosis (Disease Ontology:DOID:289); acute pancreatitis (Disease Ontology:DOID:2913); severe acute respiratory syndrome (Disease Ontology:DOID:2945); high grade glioma (Disease Ontology:DOID:3070); central nervous system lymphoma (Disease Ontology:DOID:3234); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); liver cancer (Disease Ontology:DOID:3571); toxic encephalopathy (Disease Ontology:DOID:3602); skin disease (Disease Ontology:DOID:37); bronchus carcinoma (Disease Ontology:DOID:3904); cervical cancer (Disease Ontology:DOID:4362); allergic rhinitis (Disease Ontology:DOID:4481); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); gallbladder carcinoma (Disease Ontology:DOID:4948); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); schizophrenia (Disease Ontology:DOID:5419); pneumonia (Disease Ontology:DOID:552); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); liver carcinoma (Disease Ontology:DOID:686); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); thyrotoxicosis (Disease Ontology:DOID:7997); hyperthyroidism (Disease Ontology:DOID:7998); myocarditis (Disease Ontology:DOID:820); periodontitis (Disease Ontology:DOID:824); intestinal obstruction (Disease Ontology:DOID:8437); retinal artery occlusion (Disease Ontology:DOID:8483); lung disease (Disease Ontology:DOID:850); herpes zoster (Disease Ontology:DOID:8536); chronic myeloid leukemia (Disease Ontology:DOID:8552); lip cancer (Disease Ontology:DOID:8564); Hodgkin's lymphoma (Disease Ontology:DOID:8567); ulcerative colitis (Disease Ontology:DOID:8577); vasculitis (Disease Ontology:DOID:865); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); decubitus ulcer (Disease Ontology:DOID:8717); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); cutaneous leishmaniasis (Disease Ontology:DOID:9111); acute myeloid leukemia (Disease Ontology:DOID:9119); visceral leishmaniasis (Disease Ontology:DOID:9146); liver benign neoplasm (Disease Ontology:DOID:916); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); steatotic liver disease (Disease Ontology:DOID:9452); postpartum depression (Disease Ontology:DOID:9478); pulmonary eosinophilia (Disease Ontology:DOID:9498); multiple myeloma (Disease Ontology:DOID:9538); aphthous stomatitis (Disease Ontology:DOID:9663); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:16153); (R-MMU-6783783)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1350294;16002704;2161559;28473584;8364028", "class_list": "", "function": "Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF. Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity) (PubMed:28473584)., [UniProtKB, PubMed, UniProtKB]; Production of IL-10 by primary mouse bone marrow-derived macrophages stimulated through pattern recognition receptors is associated with chromatin remodeling of the IL-10 locus., [RefSeq, PubMed]; This gene encodes an anti-inflammatory cytokine that is a member of the class-2 cytokine family. The encoded protein is secreted by cells of both the innate and adaptive immune systems and is crucial for limiting the immune response to a broad range of pathogens. It also has been shown to suppress autoimmune responses. This protein mediates it's immunosuppressive signal through a specific interleukin 10 receptor complex. Aberrant functioning of this gene is associated with numerous immune disorders including graft-versus-host disease, and increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 128, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBJ1", "ec_number_list": "", "go_molecular_function": "GO:0005141 interleukin-10 receptor binding;GO:0046983 protein dimerization activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:1905571 interleukin-10 receptor complex", "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0002875 negative regulation of chronic inflammatory response to antigenic stimulus;GO:0034465 response to carbon monoxide;GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0060302 negative regulation of cytokine activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18893-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97812-1", "uniprot_id": "IHH_MOUSE", "mass": 45485.0, "length": 411, "protein_name": "Indian hedgehog protein", "gene_name": "Ihh", "organism": "Mouse", "refseq_name": "indian hedgehog protein isoform 1 preproprotein", "refseq_ac": "NP_034674", "gene_names_uniprotkb": "Ihh", "gene_names_refseq": "HHG-2; Ihh", "protein_names_uniprotkb": "Indian hedgehog protein; 3.1.-.-; HHG-2; IHH", "protein_names_refseq": "indian hedgehog protein isoform 1 preproprotein; indian hedgehog protein", "tax_id": 10090, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); familial adenomatous polyposis (Disease Ontology:DOID:0050424); acrocapitofemoral dysplasia (Disease Ontology:DOID:0050604); autism spectrum disorder (Disease Ontology:DOID:0060041); annular pancreas (Disease Ontology:DOID:0060850); brachydactyly type A1 (Disease Ontology:DOID:0110964); syndactyly type 1 (Disease Ontology:DOID:0111816); Hirschsprung's disease (Disease Ontology:DOID:10487); retinopathy of prematurity (Disease Ontology:DOID:13025); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (mmu:16147); (R-MMU-5358346); (R-MMU-5362798); (R-MMU-5632681); (R-MMU-5635838)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10465785;10631175;18582859;19252479;23665349;7720571;7916661;9079674", "class_list": "", "function": "Precursor of indian hedgehog, a morphogen that activates the smoothened signaling pathway, and which is essential for bone and cartilage development (PubMed:10465785, PubMed:10631175, PubMed:18582859, PubMed:19252479). The C-terminal part of the precursor displays an autoproteolysis and a cholesterol transferase activity, resulting (1) in the cleavage of the full-length protein into two parts, indian hedgehog protein N-product and C-product and (2) covalent attachment of a cholesterol moiety to the C-terminus of the newly generated N-product (By similarity). Both autoproteolysis and a cholesterol transferase activities occur in the endoplasmic reticulum (By similarity). Following additional lipidation, N-product acts as a morphogen, while C-product is degraded in the endoplasmic reticulum (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The dually lipidated indian hedgehog protein N-product is a morphogen that activates the smoothened signaling pathway, and which is essential for bone and cartilage development (PubMed:10465785, PubMed:10631175, PubMed:19252479). Acts by binding to the patched receptor (PTCH1 or PTCH2), relieving smoothened (SMO) inhibition by patched, activating the smoothened signaling pathway and transcription of target genes (PubMed:19252479). In the absence of IHH, patched represses the constitutive signaling activity of SMO (By similarity). Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton (PubMed:10465785, PubMed:10631175, PubMed:19252479). Positively regulates PTHLH expression during endochondral bone formation preventing chondrocyte hypertrophy (PubMed:10465785, PubMed:10631175). In contrast, participates in normal chondrocyte proliferation in a PTHLH-independent pathway (PubMed:10631175). Involved in the development of retinal pigment epithelium (RPE), photoreceptors and periocular tissues (PubMed:18582859). Plays a role in hedgehog paracrine signaling (By similarity). Associated with the very-low-density lipoprotein (VLDL) particles to function as a circulating morphogen for endothelial cell integrity maintenance (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61724", "ec_number_list": "3.4.19.12;3.4.25.1;5.3.4.1;3.6.4.-;3.1.-.-;3.6.4.6;2.3.1.-;3.1.1.98;2.3.2.27", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0005113 patched binding;GO:0034189 very-low-density lipoprotein particle binding;GO:0140853 cholesterol-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0060323 head morphogenesis;GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway;GO:0046639 negative regulation of alpha-beta T cell differentiation;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P97812-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3I6-1", "uniprot_id": "IL27A_MOUSE", "mass": 26542.0, "length": 234, "protein_name": "Interleukin-27 subunit alpha", "gene_name": "Il27", "organism": "Mouse", "refseq_name": "interleukin-27 subunit alpha precursor", "refseq_ac": "NP_663611", "gene_names_uniprotkb": "Il27; Il27a", "gene_names_refseq": "IL-27-A; IL-27p28; IL-27; IL27-A; Il27; Il30; p28", "protein_names_uniprotkb": "Interleukin-27 subunit alpha; IL-27 subunit alpha; IL-27-A; IL27-A; p28", "protein_names_refseq": "IL-27 p28 subunit; IL-27 subunit alpha; interleukin 30; interleukin-27 subunit alpha precursor; interleukin-27 subunit alpha", "tax_id": 10090, "disease": "pleural tuberculosis (Disease Ontology:DOID:106); lepromatous leprosy (Disease Ontology:DOID:10887); IgA vasculitis (Disease Ontology:DOID:11123); duodenal ulcer (Disease Ontology:DOID:1724); hepatitis B (Disease Ontology:DOID:2043); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); tuberculosis (Disease Ontology:DOID:399); systemic scleroderma (Disease Ontology:DOID:418); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); peptic ulcer disease (Disease Ontology:DOID:750); Cor pulmonale (Disease Ontology:DOID:8515); infectious mononucleosis (Disease Ontology:DOID:8568)", "pathway": " (mmu:246779); (R-MMU-9020956)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "12121660;12734330;14565860;14657353;14871851;15253382;15585838;15688376;15804443;16034109;16365415;16493033;16751375;16906166;16906167;17015723;17114427;17294231;17548596;17549733;17709543;17727629;30084848;39171524;39276693", "class_list": "", "function": "Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of pro-inflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 also has an effect on cytokine production, it suppresses pro-inflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms, [RefSeq, PubMed]; IL-27/Blimp-1 axis regulates the differentiation and function of Tim-3+ Tregs during early pregnancy. Publication Status: Online-Only, [RefSeq, PubMed]; IL-6 (gp130) family cytokine members include CLC/NNT1/BSF3 and IL-27 [review] Review article, [RefSeq, PubMed]; Interleukin-27 signaling resists obesity by promoting the accumulation of Treg cells in visceral adipose tissue., [RefSeq, PubMed]; The IL-27/WSX-1 signaling system is a key commitment step at which naive Th precursor cells commence differentiation into Th1 cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045523 interleukin-27 receptor binding;GO:0005102 signaling receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0045625 regulation of T-helper 1 cell differentiation;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0002230 positive regulation of defense response to virus by host;GO:0032729 positive regulation of type II interferon production", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8K3I6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1R4-1", "uniprot_id": "IL34_MOUSE", "mass": 26764.0, "length": 235, "protein_name": "Interleukin-34", "gene_name": "Il34", "organism": "Mouse", "refseq_name": "interleukin-34 isoform 1 precursor", "refseq_ac": "NP_001128572", "gene_names_uniprotkb": "Il34", "gene_names_refseq": "2010004A03Rik; Il34", "protein_names_uniprotkb": "Interleukin-34; IL-34", "protein_names_refseq": "interleukin-34 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:76527); (R-MMU-449836)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "18467591;20504948;21494622;31219806", "class_list": "", "function": "Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity)., [UniProtKB]; The different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues., [RefSeq, PubMed]; This study was to explore the biological function, specifically osteoclastogenesis and bone metabolism, of il-34. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2ZC71;B2ZC72;Q9D8F2", "ec_number_list": "", "go_molecular_function": "GO:0005157 macrophage colony-stimulating factor receptor binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0043235 receptor complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006954 inflammatory response;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R1R4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R459-1", "uniprot_id": "IL1FA_MOUSE", "mass": 17078.0, "length": 152, "protein_name": "Interleukin-1 family member 10", "gene_name": "Il1f10", "organism": "Mouse", "refseq_name": "interleukin-1 family member 10 isoform 2", "refseq_ac": "NP_694717", "gene_names_uniprotkb": "Il1f10", "gene_names_refseq": "Il1f10", "protein_names_uniprotkb": "Interleukin-1 family member 10; IL-1F10", "protein_names_refseq": "IL-1F10; interleukin 1 family, member 7; interleukin-1 family member 10 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:215274); (R-MMU-9007892); (R-MMU-9014826)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11991723;28288964;35578812;37382260;38904012;39209451", "class_list": "", "function": "Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2 (By similarity)., [UniProtKB]; IL-38 Aggravates Atopic Dermatitis via Facilitating Migration of Langerhans cells. Publication Status: Online-Only, [RefSeq, PubMed]; IL-38 attenuates myocardial ischemia-reperfusion injury by inhibiting macrophage inflammation., [RefSeq, PubMed]; IL-38 overexpression attenuates the severity of experimental arthritis. IL-38 may exert its anti-inflammatory effects by decreasing the production of proinflammatory cytokines by macrophages and synovial fibroblasts., [RefSeq, PubMed]; Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent manner., [RefSeq, PubMed]; Neutralizing IL-38 activates gammadelta T cell-dependent antitumor immunity and sensitizes for chemotherapy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0071222 cellular response to lipopolysaccharide;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R459-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZ85-1", "uniprot_id": "IIGP1_MOUSE", "mass": 47572.0, "length": 413, "protein_name": "Interferon-inducible GTPase 1", "gene_name": "Iigp1", "organism": "Mouse", "refseq_name": "interferon-inducible GTPase 1", "refseq_ac": "NP_001139747", "gene_names_uniprotkb": "Iigp1; Irga6", "gene_names_refseq": "2900074L10Rik; Ifgga1; Iigp1; Iigp; Irga6", "protein_names_uniprotkb": "Interferon-inducible GTPase 1; 3.6.5.-", "protein_names_refseq": "interferon-gamma-inducible GTPase Ifgga1 protein; interferon-inducible GTPase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:60440)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11907101;12732635;15075236;15294976;16304607;18772884;18784077;19242543;21147463;21203588;22761577;22802726;24324375;24390541;24788674;25118287;25428506;26247512;26934976;32796066;34428180;9862701", "class_list": "", "function": "GTPase with low activity (PubMed:12732635). Has higher affinity for GDP than for GTP (PubMed:12732635). Plays a role in resistance to intracellular pathogens (PubMed:11907101). During infection with avirulent Toxoplasma gondii strains, recruited to the parasitophorous vacuole membrane (PubMed:24324375, PubMed:24390541, PubMed:22802726, PubMed:21203588). Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite (PubMed:16304607). Mediates resistance to Chlamydia trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction (PubMed:19242543)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Interferon-Inducible GTPase 1 Impedes the Dimerization of Rabies Virus Phosphoprotein and Restricts Viral Replication. Publication Status: Online-Only, [RefSeq, PubMed]; The study determined the crystal structure of an oligomerization-impaired Irga6 mutant bound to a non-hydrolyzable GTP analog. Publication Status: Online-Only, [RefSeq, PubMed]; These data identify Toxoplasma gondii GRA7 as a regulator for ROP18-specific inactivation of murine Irga6., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1M3", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane;GO:0020005 symbiont-containing vacuole membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0010506 regulation of autophagy;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9QZ85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0R8-1", "uniprot_id": "LSM12_MOUSE", "mass": 21701.0, "length": 195, "protein_name": "Protein LSM12", "gene_name": "Lsm12", "organism": "Mouse", "refseq_name": "protein LSM12", "refseq_ac": "NP_766535", "gene_names_uniprotkb": "Lsm12", "gene_names_refseq": "1110032E16Rik; 1110059P07; 2600001B17Rik; Lsm12", "protein_names_uniprotkb": "Protein LSM12", "protein_names_refseq": "protein LSM12 homolog; protein LSM12", "tax_id": 10090, "disease": "", "pathway": " (mmu:268490)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19144319;21183079;21750661;25605945;34362892;34428180", "class_list": "", "function": "Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein. Confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca(2+) release., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AWS3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D0R8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZWM4-1", "uniprot_id": "LSM8_MOUSE", "mass": 10403.0, "length": 96, "protein_name": "U6 snRNA-associated Sm-like protein LSm8", "gene_name": "Lsm8", "organism": "Mouse", "refseq_name": "LSM8 homolog, U6 small nuclear RNA associated", "refseq_ac": "NP_598700", "gene_names_uniprotkb": "Lsm8; LSM8", "gene_names_refseq": "2010003I05Rik; Lsm8; Naa38", "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm8", "protein_names_refseq": "LSM8 homolog, U6 small nuclear RNA associated; U6 snRNA-associated Sm-like protein LSm8", "tax_id": 10090, "disease": "", "pathway": " (mmu:76522); (R-MMU-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIX3", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome;GO:0120115 Lsm2-8 complex;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6ZWM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U419-1", "uniprot_id": "S33A2_MOUSE", "mass": 43165.0, "length": 412, "protein_name": "Solute carrier family 33 member 2", "gene_name": "Mfsd3; Slc33a2", "organism": "Mouse", "refseq_name": "solute carrier family 33 member 2", "refseq_ac": "NP_081398", "gene_names_uniprotkb": "Mfsd3; Slc33a2; Mfsd3", "gene_names_refseq": "2310010G13Rik; Mfsd3; Slc33a2", "protein_names_uniprotkb": "Solute carrier family 33 member 2; Major facilitator superfamily domain-containing protein 3", "protein_names_refseq": "major facilitator superfamily domain containing 3; major facilitator superfamily domain-containing protein 3; solute carrier family 33 member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69572)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;27981419;30084848;31219806;34428180", "class_list": "", "function": "Protein expression of MFSD3 is in mouse brain regions is specifically affected by altered nutrient uptake., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VED1;Q9D7F8", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5U419-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28825-1", "uniprot_id": "MEP1A_MOUSE", "mass": 84231.0, "length": 747, "protein_name": "Meprin A subunit alpha", "gene_name": "Mep1a", "organism": "Mouse", "refseq_name": "meprin A subunit alpha precursor", "refseq_ac": "NP_032611", "gene_names_uniprotkb": "Mep1a", "gene_names_refseq": "Mep-1a; Mep-1; Mep1a; Mep1", "protein_names_uniprotkb": "Meprin A subunit alpha; 3.4.24.18; Endopeptidase-2; MEP-1", "protein_names_refseq": "endopeptidase-2; meprin A alpha-subunit; meprin A subunit alpha precursor; meprin A subunit alpha; meprin alpha", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:17287)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11278902;1374387;16116208;17040911;17976009;1883833;1894622;1929422;1939172;21750661;31044023;33301800;34849841;8508794;8615815;9161413", "class_list": "", "function": "Identification of Mep1a as a susceptibility gene for atherosclerosis in mice., [RefSeq, PubMed]; Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 8522, "biomarker_type": "", "glycan_count": 11, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "B0V2P9;Q91WH9", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0070573 metallodipeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0017090 meprin A complex", "go_biological_process": "GO:0038004 epidermal growth factor receptor ligand maturation;GO:0140448 signaling receptor ligand precursor processing;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P28825-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09159-1", "uniprot_id": "MA2B1_MOUSE", "mass": 114648.0, "length": 1013, "protein_name": "Lysosomal alpha-mannosidase", "gene_name": "Man2b1", "organism": "Mouse", "refseq_name": "lysosomal alpha-mannosidase isoform 1 precursor", "refseq_ac": "NP_034894", "gene_names_uniprotkb": "Man2b1; Laman; Man2b; Manb", "gene_names_refseq": "LAMAN; Man2b1", "protein_names_uniprotkb": "Lysosomal alpha-mannosidase; 3.2.1.24; Laman; Lysosomal acid alpha-mannosidase; Mannosidase alpha class 2B member 1; Mannosidase alpha-B", "protein_names_refseq": "lysosomal acid alpha-mannosidase; lysosomal alpha-mannosidase isoform 1 precursor; lysosomal alpha-mannosidase; mannosidase alpha class 2B member 1; mannosidase alpha-B", "tax_id": 10090, "disease": "alpha-mannosidosis (Disease Ontology:DOID:3413)", "pathway": " (mmu:17159); (R-MMU-6798695); (R-MMU-8853383)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;11180120;11801660;16393994;18250455;20173027;21750661;26495903;26740625;27802388;28011936;29187734;30084848;30779550;30899004;31219806;31599954;34428180;35984892;36210013;37828378;9305783;9355733;9799835", "class_list": "glycogene;glycosylhydrolase", "function": "Can hydrolyze a variety of glycan substrates containing terminal alpha-mannosidic linkages. Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues on oligosaccharides generated by N-glycoprotein degradation pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 54, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 1, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "O55037;Q3UGH3;Q64443;Q9DBQ1", "ec_number_list": "4.6.1.19;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.24;4.6.1.18;3.2.1.17;1.11.2.2;3.2.1.31;3.4.16.5;3.4.16.-;3.2.1.52;3.2.1.23;3.4.21.20;2.7.10.2;2.7.11.13;3.6.1.-;1.1.1.205;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;2.7.11.24;3.1.27.-;3.4.14.1;3.6.4.6;3.5.3.15;3.4.21.37;3.1.6.4;3.4.21.76;3.5.3.1;1.6.5.5;3.5.1.26;3.1.6.14;3.1.3.16;5.3.99.3;6.3.4.21;2.4.1.1;2.3.3.8;1.8.4.-;5.3.4.1;3.2.1.51;1.6.2.2;3.4.14.2;3.4.21.4;3.4.19.9", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005537 D-mannose binding;GO:0004559 alpha-mannosidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005764 lysosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0007611 learning or memory;GO:0006013 mannose metabolic process;GO:0006516 glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "O09159-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43430-1", "uniprot_id": "MCPT8_MOUSE", "mass": 27122.0, "length": 247, "protein_name": "Mast cell protease 8", "gene_name": "Mcpt8", "organism": "Mouse", "refseq_name": "mast cell protease 8 precursor", "refseq_ac": "NP_032598", "gene_names_uniprotkb": "Mcpt8", "gene_names_refseq": "MMCP-8; Mcpt8", "protein_names_uniprotkb": "Mast cell protease 8; 3.4.21.-; mMCP-8", "protein_names_refseq": "mast cell protease 8 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17231)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11398967;17342483;21750661;26495903;9541598", "class_list": "", "function": "The proteolytic activity of mMCP-8 as a first representative for the Mcpt8-subfamilywas studied., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1F1", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P43430-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZX5-1", "uniprot_id": "LSM10_MOUSE", "mass": 13881.0, "length": 122, "protein_name": "U7 snRNA-associated Sm-like protein LSm10", "gene_name": "Lsm10", "organism": "Mouse", "refseq_name": "U7 snRNA-associated Sm-like protein LSm10", "refseq_ac": "NP_001156738", "gene_names_uniprotkb": "Lsm10", "gene_names_refseq": "Lsm10", "protein_names_uniprotkb": "U7 snRNA-associated Sm-like protein LSm10", "protein_names_refseq": "U7 snRNA-associated Sm-like protein LSm10", "tax_id": 10090, "disease": "", "pathway": " (mmu:116748); (R-MMU-111367); (R-MMU-73856); (R-MMU-77588)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "19470752;20484733;21750661;21952136;30084848;31219806;34428180", "class_list": "", "function": "Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (By similarity). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to U7 snRNA (By similarity). Binds to the downstream cleavage product (DCP) of histone pre-mRNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017069 snRNA binding;GO:0071208 histone pre-mRNA DCP binding;GO:0071209 U7 snRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0015030 Cajal body;GO:0005683 U7 snRNP;GO:0071254 cytoplasmic U snRNP body", "go_biological_process": "GO:0008380 RNA splicing;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8QZX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZ82-1", "uniprot_id": "MED18_MOUSE", "mass": 23645.0, "length": 208, "protein_name": "Mediator of RNA polymerase II transcription subunit 18", "gene_name": "Med18", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 18", "refseq_ac": "NP_080315", "gene_names_uniprotkb": "Med18; MED18", "gene_names_refseq": "2810046C01Rik; Med18", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 18; Mediator complex subunit 18", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 18; mediator of RNA polymerase II transcription, subunit 18 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67219)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZ82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C6A2-1", "uniprot_id": "MAMD1_MOUSE", "mass": 87598.0, "length": 803, "protein_name": "Mastermind-like domain-containing protein 1", "gene_name": "Mamld1", "organism": "Mouse", "refseq_name": "mastermind-like domain-containing protein 1 isoform 1", "refseq_ac": "NP_001074823", "gene_names_uniprotkb": "Mamld1", "gene_names_refseq": "G630014P10Rik; Mamld1", "protein_names_uniprotkb": "Mastermind-like domain-containing protein 1", "protein_names_refseq": "mastermind-like domain-containing protein 1 isoform 1; mastermind-like domain-containing protein 1", "tax_id": 10090, "disease": "hypospadias (Disease Ontology:DOID:10892)", "pathway": " (mmu:333639); (R-MMU-2122947); (R-MMU-350054); (R-MMU-8941856)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "18162467;21559465;21750661;22517741;23087174;25605945;26435405;28629181;32848054;40885482", "class_list": "", "function": "CXorf6 transactivates the Hes3 promoter, augments testosterone production, [RefSeq, PubMed]; MAMLD1 contributes to the maintenance of postnatal testicular growth and daily sperm production but is dispensable for androgen biosynthesis and fertility. Publication Status: Online-Only, [RefSeq, PubMed]; MAMLD1 likely participates in functional luteolysis by regulating Stat5b and other genes, independent of the PGF2alpha signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development, [RefSeq, PubMed]; Mamld1 enhances Cyp17a1 expression primarily in Leydig cells and permit to produce a sufficient amount of testosterone for male sex development, independently of the Hes3-related non-canonical Notch signaling Publication Status: Online-Only, [RefSeq, PubMed]; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ (By similarity). Required for testosterone production., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B1AW19", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0008584 male gonad development;GO:0048515 spermatid differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P0C6A2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UN90-1", "uniprot_id": "LYRM9_MOUSE", "mass": 9310.0, "length": 78, "protein_name": "LYR motif-containing protein 9", "gene_name": "Lyrm9", "organism": "Mouse", "refseq_name": "LYR motif-containing protein 9 isoform 1", "refseq_ac": "NP_001070149", "gene_names_uniprotkb": "Lyrm9; 1810012P15Rik", "gene_names_refseq": "1810012P15Rik; Lyrm9", "protein_names_uniprotkb": "LYR motif-containing protein 9", "protein_names_refseq": "LYR motif-containing protein 9 isoform 1; LYR motif-containing protein 9; UPF0631 protein C17orf108 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66274)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L3P7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UN90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27046-1", "uniprot_id": "MA2A1_MOUSE", "mass": 131631.0, "length": 1150, "protein_name": "Alpha-mannosidase 2", "gene_name": "Man2a1", "organism": "Mouse", "refseq_name": "alpha-mannosidase 2", "refseq_ac": "NP_032575", "gene_names_uniprotkb": "Man2a1; Mana2", "gene_names_refseq": "Man2a1; Mana-2; Mana2; Map-2", "protein_names_uniprotkb": "Alpha-mannosidase 2; 3.2.1.114; AMan II; Golgi alpha-mannosidase II; Man II; Mannosidase alpha class 2A member 1; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase", "protein_names_refseq": "AMan II; alpha-mannosidase 2; golgi alpha-mannosidase II; man II; mannosidase alpha class 2A member 1; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase", "tax_id": 10090, "disease": "congenital dyserythropoietic anemia (Disease Ontology:DOID:1338); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:17158); (R-MMU-975578)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;17242355;1757461;21183079;21750661;25428506;25605945;26495903;26740625;30084848;30779550;34428180;37453647;37828378", "class_list": "glycogene;glycosylhydrolase", "function": "Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 59, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B9EHS6", "ec_number_list": "3.2.1.114", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005797 Golgi medial cisterna;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0048286 lung alveolus development;GO:0007585 respiratory gaseous exchange by respiratory system", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P27046-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WV66-1", "uniprot_id": "MARH7_MOUSE", "mass": 76599.0, "length": 693, "protein_name": "E3 ubiquitin-protein ligase MARCHF7", "gene_name": "Marchf7", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MARCHF7 isoform b", "refseq_ac": "NP_065600", "gene_names_uniprotkb": "Marchf7; Axot; March7", "gene_names_refseq": "Axot; Axo; Gtrgeo17; March7; Marchf7", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF7; 2.3.2.27; Axotrophin; MARCH-VII; Membrane-associated RING finger protein 7; Membrane-associated RING-CH protein VII; RING-type E3 ubiquitin transferase MARCHF7", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH7; E3 ubiquitin-protein ligase MARCHF7 isoform b; E3 ubiquitin-protein ligase MARCHF7; MARCH-VII; RING-type E3 ubiquitin transferase MARCH7; RING-type E3 ubiquitin transferase MARCHF7; axotrophin; gene trap ROSA b-geo 17; membrane-associated RING finger protein 7; membrane-associated RING-CH protein VII; membrane-associated ring finger (C3HC4) 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:57438)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15670816;20962578;21750661;30779550;31219806", "class_list": "", "function": "Data demonstrate that T cells retain responsiveness to a LIF/Nanog axis and that this axis is linked to MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in T-cell proliferation by regulating LIF secretion. May play a role in lysosome homeostasis. Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7. Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its ubiquitination and subsequent degradation., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0036064 ciliary basal body", "go_biological_process": "GO:0002643 regulation of tolerance induction;GO:1902018 negative regulation of cilium assembly;GO:0008284 positive regulation of cell population proliferation;GO:0042130 negative regulation of T cell proliferation;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WV66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69Z36-1", "uniprot_id": "MEX3B_MOUSE", "mass": 61781.0, "length": 601, "protein_name": "RNA-binding protein MEX3B", "gene_name": "Mex3b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mex3b; Kiaa2009; Rkhd3", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA-binding protein MEX3B; RING finger and KH domain-containing protein 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:108797)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806;32782141", "class_list": "", "function": "RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q2VPR1;Q6NX84;Q8K2G2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0005634 nucleus", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0072697 protein localization to cell cortex;GO:0043547 positive regulation of GTPase activity;GO:0050766 positive regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q69Z36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0T7-1", "uniprot_id": "S67A2_MOUSE", "mass": 49663.0, "length": 466, "protein_name": "Solute carrier family 67 member A2", "gene_name": "Mfsd9; Slc67a2", "organism": "Mouse", "refseq_name": "solute carrier family 67 member A2", "refseq_ac": "NP_766087", "gene_names_uniprotkb": "Mfsd9; Slc67a2; Mfsd9", "gene_names_refseq": "4931419K03Rik; Mfsd9; Slc67a2", "protein_names_uniprotkb": "Solute carrier family 67 member A2; Major facilitator superfamily domain-containing protein 9", "protein_names_refseq": "major facilitator superfamily domain containing 9; major facilitator superfamily domain-containing protein 9; solute carrier family 67 member A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:211798)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C0T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09198-1", "uniprot_id": "MAL_MOUSE", "mass": 16596.0, "length": 153, "protein_name": "Myelin and lymphocyte protein", "gene_name": "Mal", "organism": "Mouse", "refseq_name": "myelin and lymphocyte protein isoform 2", "refseq_ac": "NP_001164658", "gene_names_uniprotkb": "Mal", "gene_names_refseq": "Mal; Mpv17; Vip17", "protein_names_uniprotkb": "Myelin and lymphocyte protein; T-lymphocyte maturation-associated protein", "protein_names_refseq": "T-lymphocyte maturation-associated protein; myelin and lymphocyte protein isoform 2", "tax_id": 10090, "disease": "metachromatic leukodystrophy (Disease Ontology:DOID:10581)", "pathway": " (mmu:17153)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15193296;15337780;31364376;33255528;9126323;9168137", "class_list": "", "function": "Absence of Mal/TIRAP Results in Abrogated Imidazoquinolinones-Dependent Activation of IRF7 and Suppressed IFNbeta and IFN-I Activated Gene Production. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in vesicular trafficking from the Golgi apparatus to the cell membrane. Plays a role in the maintenance of the myelin sheath, and in axon-glia and glia-glia interactions., [UniProtKB, PubMed]; SiRNA-mediated knockdown of MAL in cells resulted in a decrease in PLC-beta3 protein expression and an increase in PIP2, [RefSeq, PubMed]; The specific reduction and mistargeting of MAL protein as a reaction to sulfatide overload may contribute to the pathogenic mechanisms in metachromatic leukodystrophy., [RefSeq, PubMed]; This gene encodes a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The encoded protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08819;O09109;Q545Q7;Q9D2R2", "ec_number_list": "", "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0044853 plasma membrane raft;GO:0045121 membrane raft;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042552 myelination;GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0002175 protein localization to paranode region of axon;GO:0098737 protein insertion into plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O09198-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35164-1", "uniprot_id": "MCPT9_MOUSE", "mass": 26652.0, "length": 246, "protein_name": "Mast cell protease 9", "gene_name": "Mcpt9", "organism": "Mouse", "refseq_name": "mast cell protease 9 precursor", "refseq_ac": "NP_034912", "gene_names_uniprotkb": "Mcpt9", "gene_names_refseq": "MMCP-1; MMCP-9; MMCP9; Mcpt9", "protein_names_uniprotkb": "Mast cell protease 9; 3.4.21.-; mMCP-9", "protein_names_refseq": "mast cell protease 9 precursor; mast cell-specific serine protease", "tax_id": 10090, "disease": "", "pathway": " (mmu:17232)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14575687;9360993", "class_list": "", "function": "The most significant segment for positive regulation by MITF was nt -183 to -177 of the mMCP-9 promoter, CATCATG, which bound MITF-M., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0042277 peptide binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35164-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08905-1", "uniprot_id": "LYZ2_MOUSE", "mass": 16689.0, "length": 148, "protein_name": "Lysozyme C-2", "gene_name": "Lyz2", "organism": "Mouse", "refseq_name": "lysozyme C-2 precursor", "refseq_ac": "NP_059068", "gene_names_uniprotkb": "Lyz2; Lyzs; Lyz", "gene_names_refseq": "Lysm; Lys; Lyz2; Lyzf2; Lyzs; Lzm-s1; Lzm; Lzp", "protein_names_uniprotkb": "Lysozyme C-2; 1,4-beta-N-acetylmuramidase C; 3.2.1.17; Lysozyme C type M", "protein_names_refseq": "1,4-beta-N-acetylmuramidase C; lysozyme C type M; lysozyme C-2 precursor; lysozyme C-2; lysozyme f2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17105); (R-MMU-6798695); (R-MMU-6803157)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12411294;12613666;14617511;14977423;15265906;16204648;26495903;3413093;34428180", "class_list": "glycogene;glycosylhydrolase", "function": "Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz2 is active against a range of Gram-positive and Gram-negative bacteria. More effective than Lyz1 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TXG2;Q3U5Q2;Q3U690;Q8VE78", "ec_number_list": "4.6.1.19;1.11.1.27;3.1.1.4;2.3.1.23;3.2.1.24;4.6.1.18;3.2.1.18;3.4.24.34;3.4.22.27;1.1.1.42;4.1.2.13;3.4.21.4;3.4.21.-;3.2.1.17;1.16.3.1;1.11.2.2;3.2.1.31;3.4.16.5;3.4.16.-;3.4.23.5;3.2.1.52;3.2.1.23;3.3.2.6;3.4.11.4;3.4.21.20;2.7.10.2;2.7.11.13;3.1.3.48;3.4.24.35;3.6.1.-;1.1.1.205;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;3.5.4.5;2.7.11.24;3.1.27.-;3.4.14.1;3.6.4.6;3.5.3.15;3.6.5.2;3.4.21.37;3.1.6.4;3.4.21.76;3.5.3.1;1.6.5.5;3.5.1.26;3.2.1.166;3.1.6.14;3.1.3.16;1.8.3.2;5.3.99.3;6.3.4.21;2.4.1.1;1.4.3.22;1.4.3.-;2.7.1.35;3.6.1.6;2.3.1.16;2.3.1.9;2.3.1.155;2.3.3.8;1.8.4.-;5.3.4.1;3.2.1.51;2.3.2.5;5.4.2.2;3.1.21.-;3.2.1.14;1.6.2.2;3.4.14.2;3.5.1.3;3.4.18.1;3.5.1.23;3.5.1.-;3.4.19.9", "go_molecular_function": "GO:0042802 identical protein binding;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0005795 Golgi stack", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P08905-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CW03-1", "uniprot_id": "LY6C2_MOUSE", "mass": 14090.0, "length": 131, "protein_name": "Lymphocyte antigen 6C2", "gene_name": "Ly6c2", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6C2 isoform 1 precursor", "refseq_ac": "NP_001092687", "gene_names_uniprotkb": "Ly6c2; Ly6c", "gene_names_refseq": "Ly-6C.2; Ly-6C2; Ly6c2", "protein_names_uniprotkb": "Lymphocyte antigen 6C2; Ly-6C2", "protein_names_refseq": "lymphocyte antigen 6 complex, locus C2; lymphocyte antigen 6C precursor (Ly-6C); lymphocyte antigen 6C2 isoform 1 precursor; lymphocyte antigen 6C2; lymphocyte differentiation antigen", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041546)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "30084848;3335781;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09568;Q58E40;Q8C2D8", "ec_number_list": "", "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045202 synapse;GO:0098552 side of membrane", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0CW03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11034-1", "uniprot_id": "MCPT1_MOUSE", "mass": 27013.0, "length": 246, "protein_name": "Mast cell protease 1", "gene_name": "Mcpt1", "organism": "Mouse", "refseq_name": "mast cell protease 1 precursor", "refseq_ac": "NP_032596", "gene_names_uniprotkb": "Mcpt1", "gene_names_refseq": "Mcp-1; Mcpt1", "protein_names_uniprotkb": "Mast cell protease 1; 3.4.21.-; mMCP-1", "protein_names_refseq": "MMCP-1; mast cell protease 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17224)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;1517575;2060576;25339660;2706264;32005755;34297293;37358368;8363563", "class_list": "", "function": "CD8 T cells are involved in skeletal muscle regeneration through facilitating MCP-1 secretion and Gr1(high) macrophage infiltration., [RefSeq, PubMed]; Cooperative Regulation of the Mucosal Mast Cell-Specific Protease Genes Mcpt1 and Mcpt2 by GATA and Smad Transcription Factors., [RefSeq, PubMed]; Effective Model of Food Allergy in Mice Sensitized with Ovalbumin and Freud's Adjuvant., [RefSeq, PubMed]; Has a chymotrypsin-like activity., [UniProtKB]; The anti-inflammatory and bioregulatory effects of habitual exercise in high-fat diet-induced obesity involve crown-like structures and MCP-1 in white adipose tissue., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0071466 cellular response to xenobiotic stimulus;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P11034-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15119-1", "uniprot_id": "MCPT2_MOUSE", "mass": 26732.0, "length": 244, "protein_name": "Mast cell protease 2", "gene_name": "Mcpt2", "organism": "Mouse", "refseq_name": "mast cell protease 2 precursor", "refseq_ac": "NP_032597", "gene_names_uniprotkb": "Mcpt2", "gene_names_refseq": "MMCP-2; Mcp-2; Mcpt2", "protein_names_uniprotkb": "Mast cell protease 2; 3.4.21.-; mMCP-2", "protein_names_refseq": "mast cell protease 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17225)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16393974;1688433;19801677;32005755;8098710", "class_list": "", "function": "Both the accumulation and the longevity of MCP-1 in blood is due to complex formation, protecting it from a pathway that rapidly clears MCP-2, which is unable to form complexes with serpins, [RefSeq, PubMed]; Cooperative Regulation of the Mucosal Mast Cell-Specific Protease Genes Mcpt1 and Mcpt2 by GATA and Smad Transcription Factors., [RefSeq, PubMed]; Interleukin-15 transcriptionally regulates mouse mast cell protease-2, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P15119-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15265-1", "uniprot_id": "MCSP_MOUSE", "mass": 14945.0, "length": 143, "protein_name": "Sperm mitochondrial-associated cysteine-rich protein", "gene_name": "Smcp", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Smcp; Mcsp; Mcs", "gene_names_refseq": "", "protein_names_uniprotkb": "Sperm mitochondrial-associated cysteine-rich protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:17235)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11940662;1418626;2303168;8916043;9409512", "class_list": "", "function": "Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70613;Q6P8N3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0030317 flagellated sperm motility;GO:0007341 penetration of zona pellucida", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P15265-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17897-1", "uniprot_id": "LYZ1_MOUSE", "mass": 16794.0, "length": 148, "protein_name": "Lysozyme C-1", "gene_name": "Lyz1", "organism": "Mouse", "refseq_name": "lysozyme C-1 precursor", "refseq_ac": "NP_038618", "gene_names_uniprotkb": "Lyz1; Lzp-s", "gene_names_refseq": "Lyz1; Lyzf3; Lyz; Lzp-s", "protein_names_uniprotkb": "Lysozyme C-1; 1,4-beta-N-acetylmuramidase C; 3.2.1.17; Lysozyme C type P", "protein_names_refseq": "1,4-beta-N-acetylmuramidase C; P lysozyme structural; lysozyme C type P; lysozyme C-1 precursor; lysozyme C-1; lysozyme f3; renal amyloidosis", "tax_id": 10090, "disease": "", "pathway": " (mmu:17110)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14977423;2323338;2336377;28011936;38364095;39627609", "class_list": "glycogene;glycosylhydrolase", "function": "Intestinal lysozyme1 deficiency alters microbiota composition and impacts host metabolism through the emergence of NAD[+]-secreting ASTB Qing110 bacteria., [RefSeq, PubMed]; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz1 is active against a range of Gram-positive and Gram-negative bacteria. Less effective than Lyz2 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0005795 Golgi stack", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P17897-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19788-1", "uniprot_id": "MGP_MOUSE", "mass": 12359.0, "length": 104, "protein_name": "Matrix Gla protein", "gene_name": "Mgp", "organism": "Mouse", "refseq_name": "matrix Gla protein precursor", "refseq_ac": "NP_032623", "gene_names_uniprotkb": "Mgp; Mglap", "gene_names_refseq": "Mglap; Mgp", "protein_names_uniprotkb": "Matrix Gla protein; MGP", "protein_names_refseq": "matrix Gla protein precursor; matrix gamma-carboxyglutamate (gla) protein", "tax_id": 10090, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); calcinosis (Disease Ontology:DOID:182); arteriosclerosis (Disease Ontology:DOID:2349); germinoma (Disease Ontology:DOID:3304); brain infarction (Disease Ontology:DOID:3454); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (mmu:17313)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1686347;7754814", "class_list": "", "function": "Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation., [UniProtKB]; This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. This protein also inhibits angiogenesis. Mice lacking a functional copy of this gene exhibit impaired differentiation of endothelial cells, reduced stature, and calcification and rupture of the vasculature leading to premature death. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LD77;Q8JZW0", "ec_number_list": "", "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030154 cell differentiation;GO:0030324 lung development;GO:0001503 ossification;GO:0030500 regulation of bone mineralization;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P19788-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21956-1", "uniprot_id": "MFGM_MOUSE", "mass": 51241.0, "length": 463, "protein_name": "Lactadherin", "gene_name": "Mfge8", "organism": "Mouse", "refseq_name": "lactadherin isoform 1 precursor", "refseq_ac": "NP_032620", "gene_names_uniprotkb": "Mfge8", "gene_names_refseq": "MFG-E8; MP47; Mfge8; Mfgm; P47; SED1; lactadherin", "protein_names_uniprotkb": "Lactadherin; MFG-E8; MFGM; MP47; Milk fat globule-EGF factor 8; SED1; Sperm surface protein SP47", "protein_names_refseq": "EGF/factor VIII; lactadherin isoform 1 precursor; milk fat globule glycoprotein; milk fat globule-EGF factor 8 protein; sperm surface protein SP47", "tax_id": 10090, "disease": "temporal arteritis (Disease Ontology:DOID:13375)", "pathway": " (mmu:17304); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11801660;15834428;18008006;2122462;21750661;23262193;30899004;34428180;34887587;37828378;37977072;37979054;38199575;38332689;39950214;9546740;9920772", "class_list": "", "function": "Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction (By similarity). Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization., [UniProtKB, PubMed, PubMed]; MFG-E8 Alleviates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Phagocytosing Myelin Debris and Promoting Remyelination., [RefSeq, PubMed]; MFG-E8 facilitates heart repair through M1/M2 polarization after myocardial infarction by inhibiting CaMKII., [RefSeq, PubMed]; PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the beta5 integrin., [RefSeq, PubMed]; Potent CTLs can be induced against tumor cells in an environment of lower levels of systemic MFG-E8., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "P97800;Q3TBN5;Q3U8S9;Q9R1X9;Q9WTS3", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008429 phosphatidylethanolamine binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0009897 external side of plasma membrane;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006911 phagocytosis, engulfment;GO:0007155 cell adhesion;GO:0007338 single fertilization;GO:0050766 positive regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P21956-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27792-1", "uniprot_id": "LYL1_MOUSE", "mass": 30142.0, "length": 278, "protein_name": "Protein lyl-1", "gene_name": "Lyl1", "organism": "Mouse", "refseq_name": "protein lyl-1", "refseq_ac": "NP_032561", "gene_names_uniprotkb": "Lyl1; Lyl-1", "gene_names_refseq": "Lyl-1; Lyl1; bHLHa18", "protein_names_uniprotkb": "Protein lyl-1; Lymphoblastic leukemia-derived sequence 1", "protein_names_refseq": "lymphoblastic leukemia-derived sequence 1; protein lyl-1", "tax_id": 10090, "disease": "T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (mmu:17095)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "2000219;2067848;21750661;29237092;30084848;33022858;34428180;34887504;36119114", "class_list": "", "function": "In Lyl1(-/-) mice, adipose stem cell vascular niche impairment leads to premature development of fat tissues., [RefSeq, PubMed]; Lyl-1 regulates primitive macrophages and microglia development. Publication Status: Online-Only, [RefSeq, PubMed]; Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4FK84;Q8BPE2;Q923F0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0030183 B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P27792-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35461-1", "uniprot_id": "LY6G_MOUSE", "mass": 14324.0, "length": 134, "protein_name": "Lymphocyte antigen 6G", "gene_name": "Ly6g", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6G precursor", "refseq_ac": "NP_001297367", "gene_names_uniprotkb": "Ly6g", "gene_names_refseq": "Gr-1; Gr1; Ly-6G; Ly6g", "protein_names_uniprotkb": "Lymphocyte antigen 6G; Ly-6G.1; Ly-6G", "protein_names_refseq": "ly-6G.1; lymphocyte antigen 6 complex, locus G; lymphocyte antigen 6G precursor; lymphocyte antigen 6G", "tax_id": 10090, "disease": "", "pathway": " (mmu:546644)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;8515066", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A087WQF5", "ec_number_list": "", "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0009897 external side of plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35461-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39039-1", "uniprot_id": "MBL1_MOUSE", "mass": 25396.0, "length": 239, "protein_name": "Mannose-binding protein A", "gene_name": "Mbl1", "organism": "Mouse", "refseq_name": "mannose-binding protein A precursor", "refseq_ac": "NP_034905", "gene_names_uniprotkb": "Mbl1", "gene_names_refseq": "MBL-A; MBP-A; Mbl1; S-MBP", "protein_names_uniprotkb": "Mannose-binding protein A; MBP-A; Mannan-binding protein; Ra-reactive factor polysaccharide-binding component p28B; RaRF p28B", "protein_names_refseq": "mannan-binding protein; mannose binding lectin (A); mannose binding lectin, serum (A); mannose-binding protein A precursor; mannose-binding protein A; ra-reactive factor polysaccharide-binding component p28B; raRF p28B", "tax_id": 10090, "disease": "", "pathway": " (mmu:17194)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1637828;1712818;21750661;25419660;26495903;26740625;7766991", "class_list": "glycogene", "function": "Calcium-dependent lectin. Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway (By similarity). Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q0P6H1", "ec_number_list": "", "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0070492 oligosaccharide binding;GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005771 multivesicular body", "go_biological_process": "GO:0043129 surfactant homeostasis;GO:0050830 defense response to Gram-positive bacterium;GO:0050766 positive regulation of phagocytosis;GO:0070207 protein homotrimerization;GO:0001867 complement activation, lectin pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P39039-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54843-1", "uniprot_id": "MAF_MOUSE", "mass": 38435.0, "length": 370, "protein_name": "Transcription factor Maf", "gene_name": "Maf", "organism": "Mouse", "refseq_name": "transcription factor Maf isoform 2", "refseq_ac": "NP_001020748", "gene_names_uniprotkb": "Maf; Maf2", "gene_names_refseq": "2810401A20Rik; A230108G15Rik; Maf; c-maf", "protein_names_uniprotkb": "Transcription factor Maf; Proto-oncogene c-Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog", "protein_names_refseq": "V-maf musculoaponeurotic fibrosarcoma oncogene homolog; avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog; avian musculoaponeurotic fibrosarcoma oncogene homolog; c-Maf long form; proto-oncogene c-maf; transcription factor Maf isoform 2; transcription factor Maf", "tax_id": 10090, "disease": "cataract 21 multiple types (Disease Ontology:DOID:0110256); Ayme-Gripp syndrome (Disease Ontology:DOID:0111688); cataract (Disease Ontology:DOID:83); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:17132)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10097114;10383433;10403649;10603348;11943779;14512017;14707122;15249232;17823980;17897790;17901057;19143053;20485683;22798672;35820727;36210013;7799931;9070273;9566892", "class_list": "", "function": "Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters (By similarity). Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1Z2;Q4QY62", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P54843-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55002-1", "uniprot_id": "MFAP2_MOUSE", "mass": 20578.0, "length": 183, "protein_name": "Microfibrillar-associated protein 2", "gene_name": "Mfap2", "organism": "Mouse", "refseq_name": "microfibrillar-associated protein 2 isoform a precursor", "refseq_ac": "NP_001155271", "gene_names_uniprotkb": "Mfap2; Magp1; Magp", "gene_names_refseq": "MAGP-1; MFAP-2; Magp1; Magp; Mfap2", "protein_names_uniprotkb": "Microfibrillar-associated protein 2; MAGP-1; MAGP; MFAP-2; Microfibril-associated glycoprotein 1", "protein_names_refseq": "microfibril-associated glycoprotein 1A; microfibril-associated glycoprotein 1D; microfibril-associated glycoprotein 1; microfibrillar-associated protein 2 isoform a precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:17150); (R-MMU-1566948); (R-MMU-2129379)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;36583532;37635348;8262979", "class_list": "", "function": "Component of the elastin-associated microfibrils., [UniProtKB]; MFAP2 promotes HSCs activation through FBN1/TGF-beta/Smad3 pathway., [RefSeq, PubMed]; MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001968 fibronectin binding;GO:0070051 fibrinogen binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0001527 microfibril", "go_biological_process": "GO:0048048 embryonic eye morphogenesis;GO:0030220 platelet formation;GO:0048050 post-embryonic eye morphogenesis;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55002-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70187-1", "uniprot_id": "S71A1_MOUSE", "mass": 53000.0, "length": 490, "protein_name": "Solute carrier family 71 member 1", "gene_name": "Slc71a1", "organism": "Mouse", "refseq_name": "solute carrier family 71 member 1 isoform 1", "refseq_ac": "NP_032272", "gene_names_uniprotkb": "Slc71a1; Hiat1; Mfsd14a", "gene_names_refseq": "Hiat1; Mfsd14a; Slc71a1; Slc72a1", "protein_names_uniprotkb": "Solute carrier family 71 member 1; Hippocampus abundant transcript 1 protein; Major facilitator superfamily domain-containing 14A; Putative tetracycline transporter-like protein", "protein_names_refseq": "hippocampus abundant gene transcript 1; hippocampus abundant transcript 1 protein; major facilitator superfamily domain containing 14A; putative tetracycline transporter-like protein; solute carrier family 71 member 1 isoform 1; tetracycline transporter-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:15247)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "27107036;28179877;30084848;30779550;34428180;9299464", "class_list": "", "function": "Loss of Mfsd14a expression is associated with globozoospermia and male infertility., [RefSeq, PubMed]; Probable membrane-bound transporter. May play a role in neuronal nutrient sensing and energy homeostasis (PubMed:28179877). Required for the final stages of spermatogenesis (PubMed:27107036)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TY74;Q9DBS0", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0030382 sperm mitochondrion organization;GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0001675 acrosome assembly;GO:0007289 spermatid nucleus differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70187-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00356-1", "uniprot_id": "MCPTX_MOUSE", "mass": 26775.0, "length": 246, "protein_name": "Mast cell protease-like protein", "gene_name": "Mcptl", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Mcptl", "gene_names_refseq": "", "protein_names_uniprotkb": "Mast cell protease-like protein; 3.4.21.-", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1988455", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0042277 peptide binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q00356-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14BA6-1", "uniprot_id": "MEDAG_MOUSE", "mass": 34364.0, "length": 303, "protein_name": "Mesenteric estrogen-dependent adipogenesis protein", "gene_name": "Medag", "organism": "Mouse", "refseq_name": "mesenteric estrogen-dependent adipogenesis protein isoform 1", "refseq_ac": "NP_081795", "gene_names_uniprotkb": "Medag; Awms3; Meda4", "gene_names_refseq": "6330406I15Rik; Awms3; MEDA-4; Meda4; Medag; mAWMS3", "protein_names_uniprotkb": "Mesenteric estrogen-dependent adipogenesis protein; Activated in W/Wv mouse stomach 3; MEDA-4; Mesenteric estrogen-dependent adipose 4; mAWMS3", "protein_names_refseq": "activated in W/Wv mouse stomach 3; mesenteric estrogen-dependent adipogenesis protein isoform 1; mesenteric estrogen-dependent adipogenesis protein; mesenteric estrogen-dependent adipose 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:70717)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22510272", "class_list": "", "function": "Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes., [UniProtKB, PubMed]; Study identifies Meda-4 as a novel adipogenic gene, capable of promoting differentiation of preadipocytes into adipocytes, increasing lipid content and glucose uptake in adipocytes; it might play an important role in adipose tissue expansion in normal and aberrant hormonal conditions and pathophysiological states, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFY2;Q8C9B3;Q8CHK6;Q8R0K5;Q9CU47", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045600 positive regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q14BA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2TBA3-1", "uniprot_id": "MALT1_MOUSE", "mass": 93216.0, "length": 832, "protein_name": "Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog", "gene_name": "Malt1", "organism": "Mouse", "refseq_name": "mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform 1", "refseq_ac": "NP_766421", "gene_names_uniprotkb": "Malt1", "gene_names_refseq": "A630046N12; D430033E09Rik; Malt1; Pcasp1", "protein_names_uniprotkb": "Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog; 3.4.22.-; Paracaspase", "protein_names_refseq": "mucosa associated lymphoid tissue lymphoma translocation gene 1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform 1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog; paracaspase-1", "tax_id": 10090, "disease": "lymphoma (Disease Ontology:DOID:0060058); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); immunodeficiency 12 (Disease Ontology:DOID:0111988)", "pathway": " (mmu:240354); (R-MMU-1169091); (R-MMU-202424); (R-MMU-2871837); (R-MMU-5607764); (R-MMU-5660668)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "14576442;21750661;22265677;25282160;25428506;30084848;30779550;34428180;36761777;37988467;38519981", "class_list": "", "function": "Findings demonstrate that primary T and B lymphocytes from paracaspase (MALT1)-deficient mice are defective in antigen-receptor-induced NF-kappaB activation, cytokine production, and proliferation, [RefSeq, PubMed]; Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation (By similarity). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (PubMed:25282160). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions. Publication Status: Online-Only, [RefSeq, PubMed]; Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TBA2;Q811E3;Q8BFT0;Q8C7N9", "ec_number_list": "2.7.11.10;2.7.11.1;3.4.22.61;2.3.2.23;2.7.11.13;3.4.22.-;2.7.11.25", "go_molecular_function": "GO:0019209 kinase activator activity;GO:0002020 protease binding;GO:0004175 endopeptidase activity;GO:0042802 identical protein binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:2000321 positive regulation of T-helper 17 cell differentiation;GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0042113 B cell activation;GO:0050852 T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q2TBA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TZ87-1", "uniprot_id": "MARH9_MOUSE", "mass": 37888.0, "length": 348, "protein_name": "E3 ubiquitin-protein ligase MARCHF9", "gene_name": "Marchf9", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase MARCHF9", "refseq_ac": "NP_001028434", "gene_names_uniprotkb": "Marchf9; March9", "gene_names_refseq": "March9; Marchf9", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF9; 2.3.2.27; MARCH-IX; Membrane-associated RING finger protein 9; Membrane-associated RING-CH protein IX; RING-type E3 ubiquitin transferase MARCHF9", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH9; E3 ubiquitin-protein ligase MARCHF9; MARCH-IX; RING-type E3 ubiquitin transferase MARCH9; RING-type E3 ubiquitin transferase MARCHF9; membrane-associated RING finger protein 9; membrane-associated RING-CH protein IX; membrane-associated ring finger (C3HC4) 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:216438)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCL1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005765 lysosomal membrane;GO:0005795 Golgi stack;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3TZ87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UGP9-1", "uniprot_id": "LRC58_MOUSE", "mass": 40139.0, "length": 366, "protein_name": "Leucine-rich repeat-containing protein 58", "gene_name": "Lrrc58", "organism": "Mouse", "refseq_name": "leucine-rich repeat-containing protein 58", "refseq_ac": "NP_796067", "gene_names_uniprotkb": "Lrrc58", "gene_names_refseq": "1810012N18Rik; C330018J07Rik; Lrrc58", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 58", "protein_names_refseq": "leucine-rich repeat-containing protein 58", "tax_id": 10090, "disease": "", "pathway": " (mmu:320184)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;34428180;40963025", "class_list": "", "function": "Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CDO1 (PubMed:40963025). The ECS(LRRC58) complex acts as a regulator of cysteine catabolism by mediating ubiquitination and degradation of CDO1, the rate-limiting enzyme of the cysteine catabolic process to taurine (PubMed:40963025). L-cysteine abundance regulates ECS(LRRC58)-mediated ubiquitination of CDO1: the complex promotes ubiquitination and degradation of CDO1 in presence of high level of cysteine, but not when cysteine abundance is low (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RU81;Q8BX06", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0031466 Cul5-RING ubiquitin ligase complex", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0062089 regulation of taurine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UGP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F204-1", "uniprot_id": "MDH1B_MOUSE", "mass": 56297.0, "length": 500, "protein_name": "Putative malate dehydrogenase 1B", "gene_name": "Mdh1b", "organism": "Mouse", "refseq_name": "putative malate dehydrogenase 1B", "refseq_ac": "NP_083972", "gene_names_uniprotkb": "Mdh1b", "gene_names_refseq": "1700124B08Rik; Mdh1b", "protein_names_uniprotkb": "Putative malate dehydrogenase 1B; 1.1.1.-", "protein_names_refseq": "putative malate dehydrogenase 1B", "tax_id": 10090, "disease": "", "pathway": " (mmu:76668)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17971504", "class_list": "", "function": "Mdh1b is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80YT6;Q9D988", "ec_number_list": "", "go_molecular_function": "GO:0030060 L-malate dehydrogenase (NAD+) activity", "go_cellular_component": "", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006107 oxaloacetate metabolic process;GO:0019674 NAD+ metabolic process;GO:0006108 malate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F204-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6A009-1", "uniprot_id": "LTN1_MOUSE", "mass": 198921.0, "length": 1767, "protein_name": "E3 ubiquitin-protein ligase listerin", "gene_name": "Ltn1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase listerin isoform 1", "refseq_ac": "NP_001074537", "gene_names_uniprotkb": "Ltn1; Kiaa0714; Lister; Rnf160; Zfp294; Znf294", "gene_names_refseq": "4930528H02Rik; Listerin; Ltn1; Rnf160; Zfp294", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase listerin; 2.3.2.27; RING finger protein 160; RING-type E3 ubiquitin transferase listerin; Zfp-294; Zinc finger protein 294", "protein_names_refseq": "E3 ubiquitin-protein ligase listerin isoform 1; E3 ubiquitin-protein ligase listerin; RING-type E3 ubiquitin transferase listerin; ring finger protein 160; zfp-294; zinc finger protein 294", "tax_id": 10090, "disease": "", "pathway": " (mmu:78913); (R-MMU-983168); (R-MMU-9954709)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19196968;22872234;25428506;30084848;34428180;38060409;38109536", "class_list": "", "function": "E3 ubiquitin-protein ligase (PubMed:19196968). component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (By similarity). Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains (By similarity). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway., [RefSeq, PubMed]; Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QN94;Q6PIW6;Q8BZ44", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:1990112 RQC complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0051865 protein autoubiquitination;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6A009-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P1J0-1", "uniprot_id": "MANEL_MOUSE", "mass": 51106.0, "length": 452, "protein_name": "Glycoprotein endo-alpha-1,2-mannosidase-like protein", "gene_name": "Maneal", "organism": "Mouse", "refseq_name": "glycoprotein endo-alpha-1,2-mannosidase-like protein", "refseq_ac": "NP_001007574", "gene_names_uniprotkb": "Maneal; Gm50", "gene_names_refseq": "Gm50; Maneal", "protein_names_uniprotkb": "Glycoprotein endo-alpha-1,2-mannosidase-like protein; 3.2.1.-", "protein_names_refseq": "glycoprotein endo-alpha-1,2-mannosidase-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:215090)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVP2", "ec_number_list": "", "go_molecular_function": "GO:0004559 alpha-mannosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P1J0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PCZ4-1", "uniprot_id": "MAGE1_MOUSE", "mass": 101632.0, "length": 918, "protein_name": "Melanoma-associated antigen E1", "gene_name": "Magee1", "organism": "Mouse", "refseq_name": "melanoma-associated antigen E1", "refseq_ac": "NP_444431", "gene_names_uniprotkb": "Magee1", "gene_names_refseq": "DAMAGE; Magee1; mMage-e1", "protein_names_uniprotkb": "Melanoma-associated antigen E1; Alpha-dystrobrevin-associated MAGE Protein; DAMAGE; MAGE-E1 antigen", "protein_names_refseq": "MAGE-E1 antigen; alpha-dystrobrevin-associated MAGE Protein; melanoma antigen, family E, 1; melanoma-associated antigen E1", "tax_id": 10090, "disease": "", "pathway": " (mmu:107528)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14623885;32848054", "class_list": "", "function": "A new dystrobrevin-associated protein that may play a signaling role in brain, muscle, and peripheral nerve [DAMAGE], [RefSeq, PubMed]; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG82;Q8BQ37;Q99PB2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045211 postsynaptic membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PCZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQJ1-1", "uniprot_id": "MALD1_MOUSE", "mass": 19087.0, "length": 173, "protein_name": "MARVEL domain-containing protein 1", "gene_name": "Marveld1", "organism": "Mouse", "refseq_name": "MARVEL domain-containing protein 1", "refseq_ac": "NP_899018", "gene_names_uniprotkb": "Marveld1", "gene_names_refseq": "Marveld1; Mrvldc1", "protein_names_uniprotkb": "MARVEL domain-containing protein 1", "protein_names_refseq": "MARVEL domain-containing protein 1; putative MARVEL domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:277010)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21347699;21750661;28708243;30250269;36750717", "class_list": "", "function": "MARVELD1 is a microtubule-associated protein that plays an important role in cell cycle progression and migration, [RefSeq, PubMed]; MARVELD1 mediated the invasion of trophoblast cells via regulation of the expression of integrin beta4 during placenta development., [RefSeq, PubMed]; MARVELD1 regulated neuronal migration by mediating the formation of glial fibres and ITGB1/FAK signalling pathway. The depletion of MARVELD1 during mouse brain development led to the abnormity of motor and cognition functions. Publication Status: Online-Only, [RefSeq, PubMed]; Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration., [UniProtKB, PubMed]; The regulation loop of MARVELD1 interacting with PARP1 in DNA damage response maintains genome stability and promotes therapy resistance of cancer cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHQ3", "ec_number_list": "", "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TQJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH98-1", "uniprot_id": "MBOA1_MOUSE", "mass": 56160.0, "length": 492, "protein_name": "Membrane-bound glycerophospholipid O-acyltransferase 1", "gene_name": "Mboat1", "organism": "Mouse", "refseq_name": "membrane-bound glycerophospholipid O-acyltransferase 1 isoform 1", "refseq_ac": "NP_705774", "gene_names_uniprotkb": "Mboat1; Lpeat1; Oact1", "gene_names_refseq": "9130215M02Rik; LPEAT1; LPEAT; LPLAT 1; LPSAT; Mboat1; Moact1; Oact1", "protein_names_uniprotkb": "Membrane-bound glycerophospholipid O-acyltransferase 1; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase MBOAT1; 1-acylglycerophosphoserine O-acyltransferase; 2.3.1.-; 2.3.1.23; 2.3.1.n6; 2.3.1.n7; LPE acyltransferase 1; LPLAT 1; LPSAT; Lyso-PE acyltransferase; Lyso-PS acyltransferase; Lysophosphatidylethanolamine acyltransferase 1; Lysophosphatidylserine acyltransferase; Lysophospholipid acyltransferase 1; Membrane-bound O-acyltransferase domain-containing protein 1; O-acyltransferase domain-containing protein 1", "protein_names_refseq": "1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase MBOAT1; 1-acylglycerophosphoethanolamine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase MBOAT1; 1-acylglycerophosphoserine O-acyltransferase; LPE acyltransferase 1; O-acyltransferase (membrane bound) domain containing 1; O-acyltransferase domain-containing protein 1; lyso-PE acyltransferase; lyso-PS acyltransferase; lysophosphatidylethanolamine acyltransferase 1; lysophosphatidylethanolamine acyltransferase; lysophosphatidylserine acyltransferase; lysophospholipid acyltransferase 1; membrane bound O-acyl transferase family, member 1; membrane-bound O-acyltransferase domain-containing protein 1; membrane-bound glycerophospholipid O-acyltransferase 1 isoform 1; membrane-bound glycerophospholipid O-acyltransferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:218121); (R-MMU-1482801); (R-MMU-1482839)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17890783;18287005;27048541;31599954", "class_list": "", "function": "Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18287005). Acts on lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE), and to a lesser extend lysophosphatidylcholine (PubMed:18287005). Prefers oleoyl-CoA as the acyl donor and 1-oleoyl-LPE as acceptor (PubMed:18287005). May play a role in neurite outgrowth during neuronal differentiation (PubMed:27048541)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9EDS0;Q8R3T2", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;2.3.1.51;2.3.1.67;2.3.1.25;2.3.1.121;2.3.1.n6;2.3.1.n7;2.3.1.-;2.3.1.22;2.3.1.62", "go_molecular_function": "GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0016746 acyltransferase activity;GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity;GO:0106263 1-acylglycerophosphoserine O-acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036152 phosphatidylethanolamine acyl-chain remodeling;GO:0010975 regulation of neuron projection development;GO:0008654 phospholipid biosynthetic process;GO:0036150 phosphatidylserine acyl-chain remodeling;GO:0030258 lipid modification", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BH98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHC0-1", "uniprot_id": "LYVE1_MOUSE", "mass": 34574.0, "length": 318, "protein_name": "Lymphatic vessel endothelial hyaluronic acid receptor 1", "gene_name": "Lyve1", "organism": "Mouse", "refseq_name": "lymphatic vessel endothelial hyaluronic acid receptor 1 precursor", "refseq_ac": "NP_444477", "gene_names_uniprotkb": "Lyve1; Crsbp1; Xlkd1", "gene_names_refseq": "1200012G08Rik; Crsbp-1; Lyve-1; Lyve1; Xlkd1", "protein_names_uniprotkb": "Lymphatic vessel endothelial hyaluronic acid receptor 1; CRSBP-1; Cell surface retention sequence-binding protein 1; Extracellular link domain-containing protein 1; LYVE-1", "protein_names_refseq": "cell surface retention sequence binding protein-1; extra cellular link domain-containing 1; extracellular link domain-containing protein 1; lymphatic vessel endothelial HA receptor-1; lymphatic vessel endothelial HA recptor-1; lymphatic vessel endothelial hyaluronic acid receptor 1 precursor; lymphatic vessel endothelial hyaluronic acid receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:114332); (R-MMU-2142845); (R-MMU-2160916)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10037799;10187853;11719431;17330941;25428506;28011936;28179430", "class_list": "", "function": "LYVE-1 is not exclusive to the lymph vessels, [RefSeq, PubMed]; Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10187853). Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUC1;Q99NE4", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005540 hyaluronic acid binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0007155 cell adhesion;GO:0006898 receptor-mediated endocytosis;GO:0006027 glycosaminoglycan catabolic process;GO:0030214 hyaluronan catabolic process;GO:0002693 positive regulation of cellular extravasation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BHC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHE8-1", "uniprot_id": "MAIP1_MOUSE", "mass": 32985.0, "length": 291, "protein_name": "m-AAA protease-interacting protein 1, mitochondrial", "gene_name": "Maip1", "organism": "Mouse", "refseq_name": "m-AAA protease-interacting protein 1, mitochondrial precursor", "refseq_ac": "NP_001074650", "gene_names_uniprotkb": "Maip1", "gene_names_refseq": "9430016H08Rik; Maip1", "protein_names_uniprotkb": "m-AAA protease-interacting protein 1, mitochondrial; Matrix AAA peptidase-interacting protein 1", "protein_names_refseq": "m-AAA protease-interacting protein 1, mitochondrial precursor; m-AAA protease-interacting protein 1, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:68115); (R-MMU-8949664)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "25428506;27642048;30084848;34428180", "class_list": "", "function": "Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3N9", "ec_number_list": "", "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis;GO:0051204 protein insertion into mitochondrial membrane;GO:0032979 protein insertion into mitochondrial inner membrane from matrix", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BHE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BPP1-1", "uniprot_id": "MB212_MOUSE", "mass": 40907.0, "length": 359, "protein_name": "Protein mab-21-like 2", "gene_name": "Mab21l2", "organism": "Mouse", "refseq_name": "protein mab-21-like 2", "refseq_ac": "NP_035969", "gene_names_uniprotkb": "Mab21l2", "gene_names_refseq": "Mab21l2", "protein_names_uniprotkb": "Protein mab-21-like 2", "protein_names_refseq": "protein mab-21-like 2", "tax_id": 10090, "disease": "syndromic microphthalmia 14 (Disease Ontology:DOID:0111802); microphthalmia (Disease Ontology:DOID:10629); coloboma (Disease Ontology:DOID:12270)", "pathway": " (mmu:23937)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10495284;10516425;10556287;11857508;12642482;15385160;24906020;39455595", "class_list": "", "function": "Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development. Publication Status: Online-Only, [RefSeq, PubMed]; Required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning., [UniProtKB, PubMed, PubMed]; Required in developing embryos for embryonic turning, formation of the notochord, neural tube, and other organ tissues, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1B2;Q9WVF2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:0008283 cell population proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0001654 eye development;GO:0043010 camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BPP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXA0-1", "uniprot_id": "LRFN5_MOUSE", "mass": 79371.0, "length": 719, "protein_name": "Leucine-rich repeat and fibronectin type-III domain-containing protein 5", "gene_name": "Lrfn5", "organism": "Mouse", "refseq_name": "leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform 2 precursor", "refseq_ac": "NP_001297515", "gene_names_uniprotkb": "Lrfn5; Kiaa4208; Salm5", "gene_names_refseq": "C130061B21; Lrfn5; Salm5; mKIAA4208", "protein_names_uniprotkb": "Leucine-rich repeat and fibronectin type-III domain-containing protein 5", "protein_names_refseq": "leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform 2 precursor; leucine-rich repeat and fibronectin type-III domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:238205)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16828986;27225731;30899004;33300544", "class_list": "", "function": "Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity)., [UniProtKB]; These results suggest that postsynaptic SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR-RPTPs and is important for the regulation of excitatory synaptic strength. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q5DTH4;Q8BJH4;Q8BZL0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0009986 cell surface;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0043031 negative regulation of macrophage activation;GO:0099560 synaptic membrane adhesion;GO:1905606 regulation of presynapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8BXA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CF90-1", "uniprot_id": "MAFA_MOUSE", "mass": 37576.0, "length": 359, "protein_name": "Transcription factor MafA", "gene_name": "Mafa", "organism": "Mouse", "refseq_name": "transcription factor MafA", "refseq_ac": "NP_919331", "gene_names_uniprotkb": "Mafa", "gene_names_refseq": "Mafa; RIPE3b1", "protein_names_uniprotkb": "Transcription factor MafA; Pancreatic beta-cell-specific transcriptional activator; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A", "protein_names_refseq": "Mafa homolog; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; pancreatic beta-cell-specific transcriptional activator; transcription factor MafA; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A", "tax_id": 10090, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:378435)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12368292;12917329;14680841;14973194;15664997;15665000;15923615;25428506", "class_list": "", "function": "MafA has a role in regulating insulin gene expression in the liver, [RefSeq, PubMed]; MafA is a beta-cell-specific and glucose-regulated transcriptional activator for insulin gene expression and thus may be involved in the function and development of beta-cells as well as in the pathogenesis of diabetes, [RefSeq, PubMed]; These results strongly suggested that MafA was the beta-cell-enriched component of the RIPE3b1 activator, [RefSeq, PubMed]; Transcriptional factor that activates insulin gene expression (PubMed:12368292, PubMed:15665000). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15665000). Binds the insulin enhancer C1/RIPE3b element (PubMed:12917329, PubMed:14680841, PubMed:14973194, PubMed:15665000). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CF90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHX6-1", "uniprot_id": "MBTP2_MOUSE", "mass": 56960.0, "length": 515, "protein_name": "Membrane-bound transcription factor site-2 protease", "gene_name": "Mbtps2", "organism": "Mouse", "refseq_name": "membrane-bound transcription factor site-2 protease", "refseq_ac": "NP_758511", "gene_names_uniprotkb": "Mbtps2", "gene_names_refseq": "9630032G22Rik; Mbtps2", "protein_names_uniprotkb": "Membrane-bound transcription factor site-2 protease; 3.4.24.85; Endopeptidase S2P", "protein_names_refseq": "S2P endopeptidase; endopeptidase S2P; membrane-bound transcription factor protease, site 2; membrane-bound transcription factor site-2 protease; site-2 protease", "tax_id": 10090, "disease": "X-linked keratosis follicularis spinulosa decalvans (Disease Ontology:DOID:0080754); ichthyosis follicularis-alopecia-photophobia syndrome 1 (Disease Ontology:DOID:0111821); osteogenesis imperfecta type 19 (Disease Ontology:DOID:0111847); X-linked mutilating palmoplantar keratoderma with periorificial keratotic plaques (Disease Ontology:DOID:0112012)", "pathway": " (mmu:270669); (R-MMU-1655829); (R-MMU-381033); (R-MMU-8874177); (R-MMU-8874211)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19638226;32255378;34428180;35820727;36991255;37797712;37828378", "class_list": "", "function": "Data detected yy1, yy2, and mbtps2 mRNA in primary mouse neurons, microglia cells, and astrocytes. In comparison to yy2 and mbtps2, yy1 revealed the highest expression level in all cell types. Publication Status: Online-Only, [RefSeq, PubMed]; MBTPS2 acts as a regulator of lipogenesis and cholesterol synthesis through SREBP signalling in prostate cancer., [RefSeq, PubMed]; MBTPS2 exacerbates albuminuria in streptozotocin-induced type I diabetic nephropathy by promoting endoplasmic reticulum stress-mediated renal damage., [RefSeq, PubMed]; Mice heterozygous for an osteogenesis imperfecta-linked MBTPS2 variant display a compromised subchondral osteocyte lacunocanalicular network associated with abnormal articular cartilage., [RefSeq, PubMed]; Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9437, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AC85", "ec_number_list": "3.4.24.85;3.4.21.112", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0140537 transcription regulator activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045542 positive regulation of cholesterol biosynthetic process;GO:0031293 membrane protein intracellular domain proteolysis;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CHX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CI17-1", "uniprot_id": "MB213_MOUSE", "mass": 49776.0, "length": 429, "protein_name": "Protein mab-21-like 3", "gene_name": "Mab21L3", "organism": "Mouse", "refseq_name": "protein mab-21-like 3", "refseq_ac": "NP_758499", "gene_names_uniprotkb": "Mab21L3", "gene_names_refseq": "Mab21l3", "protein_names_uniprotkb": "Protein mab-21-like 3", "protein_names_refseq": "protein mab-21-like 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:242125)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKM3;Q8CE43", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CI17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIA9-1", "uniprot_id": "S71A2_MOUSE", "mass": 55087.0, "length": 507, "protein_name": "Solute carrier family 71 member 2", "gene_name": "Slc71a2", "organism": "Mouse", "refseq_name": "solute carrier family 71 member 2", "refseq_ac": "NP_001077370", "gene_names_uniprotkb": "Slc71a2; Hiatl1; Mfsd14b", "gene_names_refseq": "5730414C17Rik; Hiatl1; Mfsd14b; Slc71a2", "protein_names_uniprotkb": "Solute carrier family 71 member 2; Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain-containing 14B", "protein_names_refseq": "hippocampus abundant transcript-like 1; hippocampus abundant transcript-like protein 1; major facilitator superfamily domain containing 14B; solute carrier family 71 member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66631)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25428506;28179877;30084848;32152506", "class_list": "", "function": "Probable membrane-bound transporter. May play a role in neuronal nutrient sensing and energy homeostasis., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3UVV2;Q8VCW0", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CIA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2P1-1", "uniprot_id": "LUR1L_MOUSE", "mass": 23728.0, "length": 221, "protein_name": "Leucine rich adaptor protein 1-like", "gene_name": "Lurap1l", "organism": "Mouse", "refseq_name": "leucine rich adaptor protein 1-like", "refseq_ac": "NP_081097", "gene_names_uniprotkb": "Lurap1l; D4Bwg0951e", "gene_names_refseq": "1110029A09Rik; D4Bwg0951e; Lurap1l; WI-13707; bM350F23.1", "protein_names_uniprotkb": "Leucine rich adaptor protein 1-like", "protein_names_refseq": "amplimer WI-13707, mouse homolog; leucine rich adaptor protein 1-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:52829)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17242355", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AQI1;Q9D150", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K2P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCS6-1", "uniprot_id": "MED9_MOUSE", "mass": 15709.0, "length": 142, "protein_name": "Mediator of RNA polymerase II transcription subunit 9", "gene_name": "Med9", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 9", "refseq_ac": "NP_619616", "gene_names_uniprotkb": "Med9; Med25", "gene_names_refseq": "Med25; Med9", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 9; Mediator complex subunit 9", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 9; mediator of RNA polymerase II transcription, subunit 9 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:192191)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11997338;20484733;21952136;34428180", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHQ8;Q8R5H4", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VCS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N03-1", "uniprot_id": "M4A10_MOUSE", "mass": 28972.0, "length": 267, "protein_name": "Membrane-spanning 4-domains subfamily A member 10", "gene_name": "Ms4a10", "organism": "Mouse", "refseq_name": "membrane-spanning 4-domains subfamily A member 10 isoform 1", "refseq_ac": "NP_076018", "gene_names_uniprotkb": "Ms4a10", "gene_names_refseq": "2010001N17Rik; Ms4a10", "protein_names_uniprotkb": "Membrane-spanning 4-domains subfamily A member 10", "protein_names_refseq": "membrane-spanning 4-domains subfamily A member 10 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69826)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11245982;11401424;21750661", "class_list": "", "function": "May be involved in signal transduction as a component of a multimeric receptor complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8H8;Q9EQY8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99N03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQA5-1", "uniprot_id": "MED4_MOUSE", "mass": 29781.0, "length": 270, "protein_name": "Mediator of RNA polymerase II transcription subunit 4", "gene_name": "Med4", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 4", "refseq_ac": "NP_080395", "gene_names_uniprotkb": "Med4; Vdrip", "gene_names_refseq": "2410046H15Rik; DRIP36; HSPC126; Med4; TRAP36; Vdirp; Vdrip", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 4; Mediator complex subunit 4", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 4; mediator of RNA polymerase II transcription, subunit 4 homolog; p36 TRAP/SMCC/PC2 subunit; vitamin D receptor interacting protein", "tax_id": 10090, "disease": "cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (mmu:67381)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34301767", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]; The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter-enhancer looping., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UL96;Q8BVG6", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046966 nuclear thyroid hormone receptor binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQB2-1", "uniprot_id": "MCRI2_MOUSE", "mass": 17871.0, "length": 160, "protein_name": "MAPK regulated corepressor interacting protein 2", "gene_name": "Mcrip2", "organism": "Mouse", "refseq_name": "MAPK regulated corepressor interacting protein 2 isoform 1", "refseq_ac": "NP_080909", "gene_names_uniprotkb": "Mcrip2; Fam195a", "gene_names_refseq": "9530058B02Rik; Fam195a; Mcrip2", "protein_names_uniprotkb": "MAPK regulated corepressor interacting protein 2; Protein FAM195A", "protein_names_refseq": "MAPK regulated corepressor interacting protein 2 isoform 1; family with sequence similarity 195, member A; protein FAM195A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68241)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17242355;19144319;21183079;21750661;24129315;34088848;34428180", "class_list": "", "function": "Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0009409 response to cold;GO:0010467 gene expression;GO:0009081 branched-chain amino acid metabolic process;GO:0106106 cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CQB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQY5-1", "uniprot_id": "MAGT1_MOUSE", "mass": 37970.0, "length": 335, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1", "gene_name": "Magt1", "organism": "Mouse", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1 isoform 1 precursor", "refseq_ac": "NP_001177338", "gene_names_uniprotkb": "Magt1; Iag2", "gene_names_refseq": "2410001C15Rik; 2610529C04Rik; 2810482I07Rik; IAG2; IAP; Magt1", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1; IAP; Implantation-associated protein; MagT1; Magnesium transporter protein 1; Oligosaccharyl transferase subunit MAGT1", "protein_names_refseq": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1 isoform 1 precursor; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1; implantation-associated protein; magnesium transporter protein 1; oligosaccharyl transferase subunit MAGT1", "tax_id": 10090, "disease": "X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia (Disease Ontology:DOID:0080319); congenital disorder of glycosylation Icc (Disease Ontology:DOID:0111839); prostate cancer (Disease Ontology:DOID:10283); bacterial infectious disease (Disease Ontology:DOID:104); primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (mmu:67075); (R-MMU-5223345); (R-MMU-6798695); (R-MMU-9931295)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15804357;21750661;30779550;30899004;34428180;35163580;37381987;37453647", "class_list": "", "function": "Accessory component of the STT3B-containing form of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Also has oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Could indirectly play a role in Mg(2+) transport in epithelial cells (Probable)., [UniProtKB, UniProtKB, PubMed]; Identifed a novel gene that encodes a protein involved with Mg2+-evoked transport, MagT1; results suggest that MagT1 may provide a selective and regulated pathway for Mg2+ transport in epithelial cells[MagT1] Publication Status: Online-Only, [RefSeq, PubMed]; MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice., [RefSeq, PubMed]; Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UW45;Q9CWX5;Q9CZT3", "ec_number_list": "", "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex;GO:0160227 oligosaccharyltransferase complex B", "go_biological_process": "GO:0015693 magnesium ion transport;GO:1903830 magnesium ion transmembrane transport;GO:0050890 cognition;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9CQY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2U5-1", "uniprot_id": "NAA38_MOUSE", "mass": 13430.0, "length": 125, "protein_name": "N-alpha-acetyltransferase 38, NatC auxiliary subunit", "gene_name": "Naa38", "organism": "Mouse", "refseq_name": "N(alpha)-acetyltransferase 38, NatC auxiliary subunit", "refseq_ac": "NP_084359", "gene_names_uniprotkb": "Naa38; Lsmd1", "gene_names_refseq": "1500034E06Rik; Lsmd1; Naa38", "protein_names_uniprotkb": "N-alpha-acetyltransferase 38, NatC auxiliary subunit; LSM domain-containing protein 1", "protein_names_refseq": "LSM domain containing 1; LSM domain-containing protein 1; MAK31-like protein; N(alpha)-acetyltransferase 38, NatC auxiliary subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:78304)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05BF7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031417 NatC complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D2U5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9H3-1", "uniprot_id": "MB3L1_MOUSE", "mass": 20676.0, "length": 186, "protein_name": "Methyl-CpG-binding domain protein 3-like 1", "gene_name": "Mbd3l1", "organism": "Mouse", "refseq_name": "methyl-CpG-binding domain protein 3-like 1", "refseq_ac": "NP_082833", "gene_names_uniprotkb": "Mbd3l1; Mbd3l", "gene_names_refseq": "1700070G05Rik; 1700095H13Rik; Mbd3l1; Mbd3l", "protein_names_uniprotkb": "Methyl-CpG-binding domain protein 3-like 1; MBD3-like protein 1", "protein_names_refseq": "MBD3-like protein 1; methyl-CpG-binding domain protein 3-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73503); (R-MMU-9937850)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12504854;15456747;18942147", "class_list": "", "function": "Interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex, [RefSeq, PubMed]; Mbd3l1 and Mbd3l2 are not involved in genome-wide demethylation of paternal genomes in mouse zygotes and are dispensable for normal development., [RefSeq, PubMed]; Transcriptional repressor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8W5;Q9D2S3", "ec_number_list": "", "go_molecular_function": "GO:0008327 methyl-CpG binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006346 DNA methylation-dependent constitutive heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D9H3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB27-1", "uniprot_id": "MCTS1_MOUSE", "mass": 20555.0, "length": 181, "protein_name": "Malignant T-cell-amplified sequence 1", "gene_name": "Mcts1", "organism": "Mouse", "refseq_name": "malignant T-cell-amplified sequence 1 isoform 1", "refseq_ac": "NP_081178", "gene_names_uniprotkb": "Mcts1", "gene_names_refseq": "1500019M23Rik; MCT-1; Mcts1", "protein_names_uniprotkb": "Malignant T-cell-amplified sequence 1; MCT-1; Multiple copies T-cell malignancies 1", "protein_names_refseq": "malignant T-cell-amplified sequence 1 isoform 1; multiple copies T-cell malignancies 1", "tax_id": 10090, "disease": "immunodeficiency 118 (Disease Ontology:DOID:0061084)", "pathway": " (mmu:68995)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25428507;30391286;31156619;34203471;34428180", "class_list": "", "function": "Acetate treatment also modulated the expression of pH regulators MCT-1 and V-ATPase accompanied by altered pH homeostasis. Expression of MDR and lipid metabolism regulatory molecules was also inhibited in tumor cells upon acetate exposure., [RefSeq, PubMed]; Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. Consequently, modulates various unrelated biological processes including cell cycle regulation and DNA damage signaling and repair. Notably, it positively regulates interferon gamma immunity to mycobacteria by enhancing the translation of JAK2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUI6", "ec_number_list": "", "go_molecular_function": "GO:0043024 ribosomal small subunit binding;GO:0003743 translation initiation factor activity;GO:0000339 RNA cap binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002188 translation reinitiation;GO:0032790 ribosome disassembly;GO:0075522 IRES-dependent viral translational initiation;GO:0006351 DNA-templated transcription;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DB27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCX1-1", "uniprot_id": "MD2BP_MOUSE", "mass": 31140.0, "length": 276, "protein_name": "MAD2L1-binding protein", "gene_name": "Mad2l1bp", "organism": "Mouse", "refseq_name": "MAD2L1-binding protein", "refseq_ac": "NP_079925", "gene_names_uniprotkb": "Mad2l1bp; Mad2lbp", "gene_names_refseq": "0610009D16Rik; 2510031P20Rik; CMT2A; CMT2B; Mad2l1bp; Mad2lbp; mKIAA0110", "protein_names_uniprotkb": "MAD2L1-binding protein", "protein_names_refseq": "MAD2L1-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66591)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26544187;31219806;37334967", "class_list": "", "function": "Biallelic variants in MAD2L1BP (p31[comet]) cause female infertility characterized by oocyte maturation arrest. Publication Status: Online-Only, [RefSeq, PubMed]; May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex., [UniProtKB]; P31comet-induced cell death is mediated by interactions with Mad2 Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99J05;Q9D0Y3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:1902426 deactivation of mitotic spindle assembly checkpoint;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0007096 regulation of exit from mitosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DCX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCZ4-1", "uniprot_id": "MIC26_MOUSE", "mass": 22604.0, "length": 198, "protein_name": "MICOS complex subunit Mic26", "gene_name": "Apoo", "organism": "Mouse", "refseq_name": "MICOS complex subunit Mic26 isoform 2", "refseq_ac": "NP_001186266", "gene_names_uniprotkb": "Apoo; Fam121b; Mic23; Mic26", "gene_names_refseq": "0610008C08Rik; 1110019O03Rik; Apoo; Micos26", "protein_names_uniprotkb": "MICOS complex subunit Mic26; Apolipoprotein O; MICOS complex subunit Mic23; Protein FAM121B", "protein_names_refseq": "MICOS complex subunit Mic23; MICOS complex subunit Mic26 isoform 2; MICOS complex subunit Mic26", "tax_id": 10090, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (mmu:68316)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16956892;21296681;24743151;30084848;34428180;35460694;35820727;36288343;37088120;37995600;38830896;39927985", "class_list": "glycogene", "function": "APOO represents a link between impaired mitochondrial function and cardiomyopathy onset, and targeting APOO-dependent metabolic remodeling has potential as a strategy to adjust heart metabolism and protect the myocardium from impaired contractility., [RefSeq, PubMed]; Apolipoprotein O is the first chondroitin sulfate chain containing apolipoprotein, [RefSeq, PubMed]; Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (By similarity). Can induce cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (By similarity)., [UniProtKB, UniProtKB, PubMed]; Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARalpha-mediated functional interplay between mitochondria and peroxisomes., [RefSeq, PubMed]; Macrophage-specific deletion of MIC26 (APOO) mitigates advanced atherosclerosis by increasing efferocytosis., [RefSeq, PubMed]; MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease., [RefSeq, PubMed]; Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ASQ2;B1ASQ3;Q9D186", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9DCZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTX8-1", "uniprot_id": "MD1L1_MOUSE", "mass": 83541.0, "length": 717, "protein_name": "Mitotic spindle assembly checkpoint protein MAD1", "gene_name": "Mad1l1", "organism": "Mouse", "refseq_name": "mitotic spindle assembly checkpoint protein MAD1 isoform a", "refseq_ac": "NP_034882", "gene_names_uniprotkb": "Mad1l1; Mad1", "gene_names_refseq": "Mad1l1; Mad1", "protein_names_uniprotkb": "Mitotic spindle assembly checkpoint protein MAD1; MAD1-like protein 1; Mitotic arrest deficient 1-like protein 1", "protein_names_refseq": "MAD1-like protein 1; mitotic arrest deficient 1-like 1; mitotic arrest deficient 1-like protein 1; mitotic spindle assembly checkpoint protein MAD1 isoform a; mitotic spindle assembly checkpoint protein MAD1", "tax_id": 10090, "disease": "lymphoma (Disease Ontology:DOID:0060058); mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition (Disease Ontology:DOID:0060982); prostate cancer (Disease Ontology:DOID:10283); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (mmu:17120); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10049595;31219806;35820727;36210013;36357673;39374311;39627609", "class_list": "", "function": "Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (By similarity). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (By similarity)., [UniProtKB, UniProtKB]; MAD1 upregulation sensitizes to inflammation-mediated tumor formation. Publication Status: Online-Only, [RefSeq, PubMed]; Schizophrenia-associated Mitotic Arrest Deficient-1 (MAD1) regulates the polarity of migrating neurons in the developing neocortex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9WTX9", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0043515 kinetochore binding", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:1902426 deactivation of mitotic spindle assembly checkpoint;GO:0090235 regulation of metaphase plate congression;GO:0051301 cell division;GO:0042130 negative regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9WTX8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1Q3-1", "uniprot_id": "LY66D_MOUSE", "mass": 14092.0, "length": 135, "protein_name": "Lymphocyte antigen 6 complex locus protein G6d", "gene_name": "Ly6g6d", "organism": "Mouse", "refseq_name": "lymphocyte antigen 6 complex locus protein G6d isoform 1 precursor", "refseq_ac": "NP_258439", "gene_names_uniprotkb": "Ly6g6d; Ng25", "gene_names_refseq": "A930024F17Rik; G6d; G6f; Ly6g6d; MEGT1; NG25; NG32; g6f-ly6g6d", "protein_names_uniprotkb": "Lymphocyte antigen 6 complex locus protein G6d", "protein_names_refseq": "lymphocyte antigen 6 complex locus protein G6d isoform 1 precursor; lymphocyte antigen 6 complex locus protein G6d; lymphocyte antigen 6 complex, locus G6D; megakaryocyte-enhanced gene transcript 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:114654); (R-MMU-163125)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12079290;14656967;17008713", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0045202 synapse;GO:0009897 external side of plasma membrane;GO:0030175 filopodium;GO:0032991 protein-containing complex", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z1Q3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41251-1", "uniprot_id": "NRAM1_MOUSE", "mass": 59741.0, "length": 548, "protein_name": "Natural resistance-associated macrophage protein 1", "gene_name": "Slc11a1", "organism": "Mouse", "refseq_name": "natural resistance-associated macrophage protein 1 isoform 1", "refseq_ac": "NP_038640", "gene_names_uniprotkb": "Slc11a1; Bcg; Ity; Lsh; Nramp1", "gene_names_refseq": "Bcg; Ity1; Ity; Lsh; Nramp1; Nramp; Slc11a1; ity", "protein_names_uniprotkb": "Natural resistance-associated macrophage protein 1; NRAMP 1; Solute carrier family 11 member 1", "protein_names_refseq": "host resistance locus Bcg/Ity/Lsh; natural resistance-associated macrophage protein 1 isoform 1; natural resistance-associated macrophage protein 1; solute carrier family 11 member 1", "tax_id": 10090, "disease": "Buruli ulcer disease (Disease Ontology:DOID:0050456); inflammatory bowel disease (Disease Ontology:DOID:0050589); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); leprosy (Disease Ontology:DOID:1024); urinary bladder cancer (Disease Ontology:DOID:11054); sarcoidosis (Disease Ontology:DOID:11335); iron deficiency anemia (Disease Ontology:DOID:11758); Behcet's disease (Disease Ontology:DOID:13241); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); systemic scleroderma (Disease Ontology:DOID:418); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); gastrointestinal system disease (Disease Ontology:DOID:77); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); cutaneous leishmaniasis (Disease Ontology:DOID:9111); visceral leishmaniasis (Disease Ontology:DOID:9146); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:18173); (R-MMU-1222556); (R-MMU-425410); (R-MMU-6798695); (R-MMU-6803544)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "11237855;15202932;21750661;30084848;30779550;34428180;36792680;7513015;7665187;8490962;8757814;8871656;9730978", "class_list": "", "function": "Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Slc11a1 gene polymorphism influences dextran sulfate sodium (DSS)-induced colitis in a murine model of acute inflammation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB84", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005384 manganese ion transmembrane transporter activity;GO:0046915 transition metal ion transmembrane transporter activity;GO:0051139 metal cation:proton antiporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0070821 tertiary granule membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression;GO:0032496 response to lipopolysaccharide;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P41251-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BNJ3-1", "uniprot_id": "NMNA2_MOUSE", "mass": 34505.0, "length": 307, "protein_name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2", "gene_name": "Nmnat2", "organism": "Mouse", "refseq_name": "nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 isoform 1", "refseq_ac": "NP_780669", "gene_names_uniprotkb": "Nmnat2; Kiaa0479", "gene_names_refseq": "D030041I09Rik; Nmnat2; PNAT1; PNAT2", "protein_names_uniprotkb": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; 2.7.7.18; 2.7.7.1; Blad; NMN adenylyltransferase 2; NMN/NaMN adenylyltransferase 2; NaMN adenylyltransferase 2; Nicotinamide mononucleotide adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2; Protein bloated bladder", "protein_names_refseq": "NMN adenylyltransferase 2; NMN/NaMN adenylyltransferase 2; blad; naMN adenylyltransferase 1; naMN adenylyltransferase 2; nicotinamide mononucleotide adenylyltransferase 2; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 isoform 1; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; nicotinate-nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 2; protein bloated bladder; pyridine nucleotide adenylyltransferase 2", "tax_id": 10090, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (mmu:226518); (R-MMU-196807)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;19778564;20126265;20943658;21750661;22425156;23082226;23610559;23665224;25818290;30084848;36322391;38282024", "class_list": "", "function": "Loss-of-function approach using mouse retinal explants showed pivotal roles of Nmnat2 in early and middle stages of retinal development., [RefSeq, PubMed]; NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport. Publication Status: Online-Only, [RefSeq, PubMed]; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (PubMed:20126265, PubMed:23082226). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (PubMed:20126265, PubMed:23082226, PubMed:25818290). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (By similarity). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate (By similarity). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16 (By similarity). May be involved in the maintenance of axonal integrity (PubMed:22425156)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Nmnat2 is a neuronal protein peripherally attached to membranes via palmitoylation and suggest that Nmnat2 is transported to synaptic terminals via an endosomal pathway., [RefSeq, PubMed]; The brain-specific Nmnat2 delays injury-induced axon degeneration dependent on its NAD synthesis activity. These findings provide new clues to further study the molecular mechanisms of axon degeneration and the related neurodegenerative diseases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.1;2.7.7.18", "go_molecular_function": "GO:0005524 ATP binding;GO:0004515 nicotinate-nucleotide adenylyltransferase activity;GO:0000309 nicotinamide-nucleotide adenylyltransferase activity;GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030424 axon;GO:0045202 synapse", "go_biological_process": "GO:0006741 NADP+ biosynthetic process;GO:0009435 NAD+ biosynthetic process;GO:0002181 cytoplasmic translation;GO:2000766 negative regulation of cytoplasmic translation;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8BNJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UEZ8-1", "uniprot_id": "NTCP4_MOUSE", "mass": 46642.0, "length": 437, "protein_name": "Putative sodium/bile acid cotransporter 4", "gene_name": "Slc10a4", "organism": "Mouse", "refseq_name": "putative sodium/bile acid cotransporter 4", "refseq_ac": "NP_775579", "gene_names_uniprotkb": "Slc10a4", "gene_names_refseq": "E130304D01; Slc10a4", "protein_names_uniprotkb": "Putative sodium/bile acid cotransporter 4; Na(+)/bile acid cotransporter 4; Solute carrier family 10 member 4", "protein_names_refseq": "Na(+)/bile acid cotransporter 4; putative sodium/bile acid cotransporter 4; sodium/bile acid cotransporter 4; solute carrier family 10 member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:231290)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18355966;21750661;23022458;23589386;25176177;25410831;38160852", "class_list": "", "function": "Absence of the recently discovered synaptic vesicle protein Slc10a4 results in increased sensitivity to cholinergic stimulation Erratum:[Exp Neurol. 2013 Sep;247:750. Leao, R [corrected to Leao, R N]], [RefSeq, PubMed]; No significant bile acid transporter activity could be measured despite its similarity to bile acid:sodium symporters., [UniProtKB, UniProtKB]; Results demonstrate that SLC10A4 is a vesicular monoaminergic and cholinergic associated transporter that is important for dopamine homeostasis and neuromodulation in vivo, [RefSeq, PubMed]; Results suggest that VAAT modulates neuromuscular junction transmission efficiency and, as such, may represent a novel target for treatment of disorders affecting motor neurons, [RefSeq, PubMed]; Unraveling the role of Slc10a4 in auditory processing and sensory motor gating: Implications for neuropsychiatric disorders?, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJC7", "ec_number_list": "", "go_molecular_function": "GO:0008508 bile acid:sodium symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0098981 cholinergic synapse;GO:0098691 dopaminergic synapse;GO:0099154 serotonergic synapse", "go_biological_process": "GO:0030534 adult behavior;GO:0015721 bile acid and bile salt transport;GO:0009410 response to xenobiotic stimulus;GO:0099162 regulation of neurotransmitter loading into synaptic vesicle", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UEZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJF0-1", "uniprot_id": "NP1L5_MOUSE", "mass": 17024.0, "length": 156, "protein_name": "Nucleosome assembly protein 1-like 5", "gene_name": "Nap1l5", "organism": "Mouse", "refseq_name": "nucleosome assembly protein 1-like 5", "refseq_ac": "NP_067407", "gene_names_uniprotkb": "Nap1l5; MNCb-0385", "gene_names_refseq": "1110020M21Rik; Nap1l5", "protein_names_uniprotkb": "Nucleosome assembly protein 1-like 5; Histone chaperone NAP1L5", "protein_names_refseq": "histone chaperone NAP1L5; nucleosome assembly protein 1-like 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:58243)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15465498;21750661;22790983", "class_list": "", "function": "Allele-specific polyadenylation occurs at the imprinted Herc3/Nap1l5 locus., [RefSeq, PubMed]; Nap1l5 expression is localised mainly to the adrenal medulla, whilst Peg13 expression is observed more generally throughout the adrenal medulla and the outer cortical layers, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JJF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JM14-1", "uniprot_id": "NT5C_MOUSE", "mass": 23076.0, "length": 200, "protein_name": "5'(3')-deoxyribonucleotidase, cytosolic type", "gene_name": "Nt5c", "organism": "Mouse", "refseq_name": "5'(3')-deoxyribonucleotidase, cytosolic type isoform 1", "refseq_ac": "NP_056622", "gene_names_uniprotkb": "Nt5c; Dnt1", "gene_names_refseq": "Dnt1; Dnt; Nt5c; Umph-2; Umph2", "protein_names_uniprotkb": "5'(3')-deoxyribonucleotidase, cytosolic type; 3.1.3.-; Cytosolic 5',3'-pyrimidine nucleotidase; Deoxy-5'-nucleotidase 1; dNT-1", "protein_names_refseq": "5' nucleotidase, deoxy (pyrimidine), cytosolic type C; 5'(3')-deoxyribonucleotidase, cytosolic type isoform 1; 5'(3')-deoxyribonucleotidase, cytosolic type; cytosolic 5',3'-pyrimidine nucleotidase; dNT-1; deoxy-5'-nucleotidase 1; uridine monophosphatase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:50773); (R-MMU-73621); (R-MMU-74259)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10681516;12234672;17985935;21183079;21750661;28059163;31219806;34428180", "class_list": "", "function": "Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.5;3.1.3.89;3.1.3.99;2.7.1.77;3.1.3.91;3.1.3.35;3.1.3.-", "go_molecular_function": "GO:0008254 3'-nucleotidase activity;GO:0008252 nucleotidase activity;GO:0019103 pyrimidine nucleotide binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0046079 dUMP catabolic process;GO:0016311 dephosphorylation;GO:0009223 pyrimidine deoxyribonucleotide catabolic process;GO:0009264 deoxyribonucleotide catabolic process;GO:0046038 GMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JM14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AEP0-1", "uniprot_id": "OBP1B_MOUSE", "mass": 19394.0, "length": 171, "protein_name": "Odorant-binding protein 1b", "gene_name": "Obp1b", "organism": "Mouse", "refseq_name": "odorant-binding protein 1b precursor", "refseq_ac": "NP_001297257", "gene_names_uniprotkb": "Obp1b", "gene_names_refseq": "EG628991; OBP-1b; OBP7; Obp1b", "protein_names_uniprotkb": "Odorant-binding protein 1b; Odorant-binding protein IB", "protein_names_refseq": "odorant binding protein 7; odorant-binding protein 1b precursor; odorant-binding protein 1b; odorant-binding protein Ib", "tax_id": 10090, "disease": "", "pathway": " (mmu:628991)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8529023;9661663", "class_list": "", "function": "Binds the chemical odorant 2-isobutyl-3-methoxypyrazine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97337", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2AEP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810Q5-1", "uniprot_id": "CX4L3_MOUSE", "mass": 9584.0, "length": 83, "protein_name": "Cytochrome c oxidase associated subunit FA4L3", "gene_name": "Coxfa4l3", "organism": "Mouse", "refseq_name": "cytochrome c oxidase associated subunit FA4L3", "refseq_ac": "NP_001004174", "gene_names_uniprotkb": "Coxfa4l3; AA467197; Nmes1", "gene_names_refseq": "AA467197; Coxfa4l3; Nmes1; mir-147", "protein_names_uniprotkb": "Cytochrome c oxidase associated subunit FA4L3; Normal mucosa of esophagus-specific gene 1 protein", "protein_names_refseq": "cytochrome c oxidase associated subunit FA4L3; normal mucosa of esophagus specific 1; normal mucosa of esophagus-specific gene 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:433470)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12209954;21750661;22299025;25428506;30084848;32045714;34878835;37971166;38296961;38917002", "class_list": "", "function": "Coxfa4l3, a novel mitochondrial electron transport chain Complex 4 subunit protein, switches from Coxfa4 during spermatogenesis., [RefSeq, PubMed]; Mitochondrial small peptide that orchestrates a two-pronged immunoregulatory mechanism in response to inflammatory stimuli. Replaces the canonical cytochrome c oxidase subunit COXFA4 in mitochondrial complex IV and targets it to degradation, attenuating mitochondrial respiration, reducing membrane potential as well as ROS generation and modulates innate immune signaling (PubMed:34878835, PubMed:38917002). Additionally, initiates stress-independent autophagy by lowering ATP levels, activating AMPK-ULK1 signaling, boosting glutathione production, and thereby mitigating oxidative stress and supporting immune tolerance (PubMed:38296961)., [UniProtKB, PubMed, PubMed, PubMed]; Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential., [RefSeq, PubMed]; The epithelial C15ORF48/miR-147-NDUFA4 axis is an essential regulator of gut inflammation, energy metabolism, and the microbiome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q810Q5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55239-1", "uniprot_id": "NNMT_MOUSE", "mass": 29598.0, "length": 264, "protein_name": "Nicotinamide N-methyltransferase", "gene_name": "Nnmt", "organism": "Mouse", "refseq_name": "nicotinamide N-methyltransferase isoform 1", "refseq_ac": "NP_035054", "gene_names_uniprotkb": "Nnmt", "gene_names_refseq": "Nnmt", "protein_names_uniprotkb": "Nicotinamide N-methyltransferase; 2.1.1.1", "protein_names_refseq": "nicotinamide N-methyltransferase isoform 1", "tax_id": 10090, "disease": "left ventricular failure (Disease Ontology:DOID:0051064); coronary artery disease (Disease Ontology:DOID:3393); renal cell carcinoma (Disease Ontology:DOID:4450); abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (mmu:18113); (R-MMU-156581); (R-MMU-196807)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "21750661;24717514;26168293;29483571;30084848;31219806;35705545;37014628;37953778;9464457;9726248", "class_list": "", "function": "Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:26168293, PubMed:29483571). Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases (By similarity). Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (By similarity). Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis (PubMed:24717514, PubMed:26168293). In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (PubMed:24717514). Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (PubMed:26168293). Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Elucidating the role of nicotinamide N-methyltransferase-p53 axis in the progression of chronic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]; Nicotinamide-N-methyltransferase regulates lipid metabolism via SAM and 1-methylnicotinamide in the AML12 hepatocyte cell line., [RefSeq, PubMed]; Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.1", "go_molecular_function": "GO:0008112 nicotinamide N-methyltransferase activity;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0032259 methylation;GO:0045722 positive regulation of gluconeogenesis;GO:0090312 positive regulation of protein deacetylation;GO:0006769 nicotinamide metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O55239-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR53-1", "uniprot_id": "NMB_MOUSE", "mass": 13571.0, "length": 121, "protein_name": "Neuromedin-B", "gene_name": "Nmb", "organism": "Mouse", "refseq_name": "neuromedin-B isoform 2 preproprotein", "refseq_ac": "NP_080799", "gene_names_uniprotkb": "Nmb", "gene_names_refseq": "3110023K12Rik; Nmb", "protein_names_uniprotkb": "Neuromedin-B", "protein_names_refseq": "neuromedin-B isoform 2 preproprotein", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:68039); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "15158442;17766645;21750661;22262690;22776446;26855425;28780306;30734045;31601264;34133943;34203471", "class_list": "", "function": "Lysosomal degradation of neuromedin B is dependent on tripeptidyl peptidase-I, [RefSeq, PubMed]; REsults describe the expression of neuromedin B in adipose tissue and its regulation by changes in energy balance., [RefSeq, PubMed]; Stimulates smooth muscle contraction (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (PubMed:34133943). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneeze reflex (PubMed:34133943). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (PubMed:30734045). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (PubMed:28780306)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The data demonstrated that the neuromedin B-neuromedian B receptor interaction in pregnant myometrial primary cells in vitro predominantly influenced uterine activity through regulation of Il6 expression via the Rela/p65 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The majority of dorsal spinal cord Grp is synthesized locally in dorsal spinal cord neurons while Nmb is highly expressed in pain- and itch-sensing dorsal root ganglion neurons. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in satiety, reproduction and thermoregulation, as well as in stress, fear and other behavioral responses. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031710 neuromedin B receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0043005 neuron projection;GO:0005576 extracellular region", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CR53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5H8A1-1", "uniprot_id": "NMS_MOUSE", "mass": 17883.0, "length": 153, "protein_name": "Neuromedin-S", "gene_name": "Nms", "organism": "Mouse", "refseq_name": "neuromedin-S isoform 1 preproprotein", "refseq_ac": "NP_001011684", "gene_names_uniprotkb": "Nms", "gene_names_refseq": "Nms", "protein_names_uniprotkb": "Neuromedin-S", "protein_names_refseq": "neuromedin S precursor-related peptide/neuromedin S preproprotein; neuromedin-S isoform 1 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:433292); (R-MMU-375276); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "15635449;17870195;21356261;21750661;26826380;35908898;36336170", "class_list": "", "function": "Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions., [UniProtKB]; NMS is implicated in the regulation of circadian rhythm and feeding behavior, [RefSeq, PubMed]; Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity., [RefSeq, PubMed]; Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis., [RefSeq, PubMed]; Results suggest that endogenous NMS may regulate cardiovascular function by activating the sympathetic nervous system., [RefSeq, PubMed]; These results suggest that NMU and NMS are involved in thermoregulation via the prostaglandin E2 and beta3 adrenergic receptors, but that endogenous NMS might play a more predominant role than NMU., [RefSeq, PubMed]; This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in the regulation of circadian rhythm, anorexigenic action, antidiuretic action, cardiovascular function and stimulation of oxytocin and vasopressin release. Mice lacking the encoded neuropeptide exhibit decreased heart rate without any accompanying changes in blood pressure. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature peptide. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSM4", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0045475 locomotor rhythm", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5H8A1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q9A9-1", "uniprot_id": "OAS2_MOUSE", "mass": 85051.0, "length": 742, "protein_name": "2'-5'-oligoadenylate synthase 2", "gene_name": "Oas2", "organism": "Mouse", "refseq_name": "2'-5'-oligoadenylate synthase 2 isoform 1", "refseq_ac": "NP_001334377", "gene_names_uniprotkb": "Oas2; oasl11", "gene_names_refseq": "Oas2; Oasl11", "protein_names_uniprotkb": "2'-5'-oligoadenylate synthase 2; (2-5')oligo(A) synthase 2; 2',5'-oligoadenylate synthetase-like 11; 2-5A synthase 2; 2.7.7.84", "protein_names_refseq": "(2-5')oligo(A) synthase 2; 2',5'-oligoadenylate synthetase-like 11; 2'-5'-oligoadenylate synthase 2 isoform 1; 2'-5'-oligoadenylate synthase 2; 2,5-oligoadenylate synthetase-like 11; 2-5A synthase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:246728)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12080145;12396720;15865429;17024523;21142819;21750661;29117179", "class_list": "", "function": "A non-synonymous mutation in Oas2 (I405N) in the viral sensor Oas2 was found and the mutation caused post-partum failure of lactation in healthy mice with otherwise normally developed mammary glands, characterized by greatly reduced milk protein synthesis coupled with epithelial cell death, inhibition of proliferation and a robust interferon response. The mutation activates the OAS2 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:12396720, PubMed:29117179). Activated by detection of double stranded RNA (dsRNA): catalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:29117179). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:21142819). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (PubMed:29117179). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (PubMed:29117179)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4E5;Q8VI92", "ec_number_list": "2.7.7.84", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070106 interleukin-27-mediated signaling pathway;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0009617 response to bacterium;GO:0060337 type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "E9Q9A9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70340-1", "uniprot_id": "NPTX2_MOUSE", "mass": 47137.0, "length": 429, "protein_name": "Neuronal pentraxin-2", "gene_name": "Nptx2", "organism": "Mouse", "refseq_name": "neuronal pentraxin-2 precursor", "refseq_ac": "NP_058069", "gene_names_uniprotkb": "Nptx2", "gene_names_refseq": "Narp; Nptx2; np2", "protein_names_uniprotkb": "Neuronal pentraxin-2; NP-II; NP2; Neuronal pentraxin II", "protein_names_refseq": "NP-II; neuro activity regulated petaxin; neuronal pentraxin II; neuronal pentraxin-2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:53324)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;16763034;30899004;33300544;35501343;36989373;38597235", "class_list": "", "function": "Inhibition of neuronal pentraxin 2 relieved epileptic seizure via reducing GluA1 phosphorylation., [RefSeq, PubMed]; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity)., [UniProtKB]; Neuronal pentraxin 1 and 2 are necessary for early synaptic refinements in mammalian retina and dorsal lateral geniculate nucleus. May exert their effects through mechanisms paralleling known role of short pentraxins outside the CNS. (Pentraxin 1 and 2), [RefSeq, PubMed]; Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch. Publication Status: Online-Only, [RefSeq, PubMed]; The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0045202 synapse;GO:0043083 synaptic cleft;GO:0098793 presynapse;GO:0098892 extrinsic component of postsynaptic specialization membrane", "go_biological_process": "GO:0008306 associative learning;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O70340-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70584-1", "uniprot_id": "NKX28_MOUSE", "mass": 26133.0, "length": 235, "protein_name": "Homeobox protein Nkx-2.8", "gene_name": "Nkx2-8", "organism": "Mouse", "refseq_name": "homeobox protein Nkx-2.8", "refseq_ac": "NP_032727", "gene_names_uniprotkb": "Nkx2-8; Nkx-2.9; Nkx2-9; Nkx2h", "gene_names_refseq": "Nkx-2.9; Nkx2-8; Nkx2-9; Nkx2.9; tinman", "protein_names_uniprotkb": "Homeobox protein Nkx-2.8; Homeobox protein NK-2 homolog H; Homeobox protein Nkx-2.9", "protein_names_refseq": "Drosophila NK2 transcription factor related, locus 9; NK2 transcription factor related, locus 9; homeobox protein NK-2 homolog H; homeobox protein Nkx-2.8; homeobox protein Nkx-2.9", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:18094)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34884468;9545546", "class_list": "", "function": "Nkx2.9 Contributes to Mid-Hindbrain Patterning by Regulation of mdDA Neuronal Cell-Fate and Repression of a Hindbrain-Specific Cell-Fate. Publication Status: Online-Only, [RefSeq, PubMed]; Possible role in the specification of a distinct subset of neurons., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RWY9", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O70584-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03888-1", "uniprot_id": "NU1M_MOUSE", "mass": 36059.0, "length": 318, "protein_name": "NADH-ubiquinone oxidoreductase chain 1", "gene_name": "Mtnd1", "organism": "Mouse", "refseq_name": "NADH dehydrogenase subunit 1", "refseq_ac": "NP_904328", "gene_names_uniprotkb": "Mtnd1; Nd1; mt-Nd1", "gene_names_refseq": "ND1", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 1; 7.1.1.2; NADH dehydrogenase subunit 1", "protein_names_refseq": "NADH dehydrogenase subunit 1", "tax_id": 10090, "disease": "Wolfram syndrome (Disease Ontology:DOID:10632); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); anterior ischemic optic neuropathy (Disease Ontology:DOID:12010); Friedreich ataxia (Disease Ontology:DOID:12705); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377); bipolar disorder (Disease Ontology:DOID:3312); MELAS syndrome (Disease Ontology:DOID:3687); peripheral nervous system disease (Disease Ontology:DOID:574); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); rheumatoid arthritis (Disease Ontology:DOID:7148); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:17716); (R-MMU-5419276); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11535650;12954771;33300544;34428180;37507081;38575788;7332926", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9G0S6", "ec_number_list": "2.1.1.-;1.-.-.-;7.1.1.9;7.1.1.2;1.3.8.7;1.3.8.8;3.1.1.29;2.1.1.320;3.6.5.-", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0001666 response to hypoxia;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0009410 response to xenobiotic stimulus;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P03888-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03899-1", "uniprot_id": "NU3M_MOUSE", "mass": 13219.0, "length": 115, "protein_name": "NADH-ubiquinone oxidoreductase chain 3", "gene_name": "mt-Nd3", "organism": "Mouse", "refseq_name": "NADH dehydrogenase subunit 3", "refseq_ac": "NP_904335", "gene_names_uniprotkb": "mt-Nd3; Nd3", "gene_names_refseq": "ND3", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 3; 7.1.1.2; NADH dehydrogenase subunit 3", "protein_names_refseq": "NADH dehydrogenase subunit 3", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); Leigh disease (Disease Ontology:DOID:3652); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (mmu:17718); (R-MMU-5419276); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11535650;12954771;34428180;37453647;38575788;7332926;8022788", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:38575788). Essential for the catalytic activity of complex I (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q35039;Q35040;Q9MD73", "ec_number_list": "2.1.1.-;1.-.-.-;7.1.1.9;7.1.1.2;1.3.8.7;1.3.8.8;3.1.1.29;2.1.1.320;3.6.5.-", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0009725 response to hormone;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0071385 cellular response to glucocorticoid stimulus;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P03899-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03921-1", "uniprot_id": "NU5M_MOUSE", "mass": 68475.0, "length": 607, "protein_name": "NADH-ubiquinone oxidoreductase chain 5", "gene_name": "Mtnd5", "organism": "Mouse", "refseq_name": "NADH dehydrogenase subunit 5", "refseq_ac": "NP_904338", "gene_names_uniprotkb": "Mtnd5; Nd5; mt-Nd5", "gene_names_refseq": "ND5", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 5; 7.1.1.2; NADH dehydrogenase subunit 5", "protein_names_refseq": "NADH dehydrogenase subunit 5", "tax_id": 10090, "disease": "Leigh disease (Disease Ontology:DOID:3652); MELAS syndrome (Disease Ontology:DOID:3687); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (mmu:17721); (R-MMU-5419276); (R-MMU-611105); (R-MMU-6799198)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12954771;33300544;34428180;37507081;38575788;39927985;7332926", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:38575788). Essential for the catalytic activity and assembly of complex I (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.-;1.-.-.-;7.1.1.9;7.1.1.2;1.3.8.7;1.3.8.8;3.1.1.29;2.1.1.320;3.6.5.-", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration;GO:0015990 electron transport coupled proton transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P03921-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30548-1", "uniprot_id": "NK1R_MOUSE", "mass": 46322.0, "length": 407, "protein_name": "Substance-P receptor", "gene_name": "Tacr1", "organism": "Mouse", "refseq_name": "substance-P receptor", "refseq_ac": "NP_033339", "gene_names_uniprotkb": "Tacr1; Tac1r", "gene_names_refseq": "Nk1r; Spr; Tac1r; Tacr1", "protein_names_uniprotkb": "Substance-P receptor; NK-1 receptor; NK-1R; SPR; Tachykinin receptor 1", "protein_names_refseq": "Nk1 receptor; neurokinin receptor 1; substance P receptor; substance-P receptor", "tax_id": 10090, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); colitis (Disease Ontology:DOID:0060180); exercise-induced bronchoconstriction (Disease Ontology:DOID:0080821); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); cystitis (Disease Ontology:DOID:1679); asthma (Disease Ontology:DOID:2841); allergic rhinitis (Disease Ontology:DOID:4481); pancreatitis (Disease Ontology:DOID:4989); pulmonary hypertension (Disease Ontology:DOID:6432); central sleep apnea (Disease Ontology:DOID:9220)", "pathway": " (mmu:21336); (R-MMU-380095); (R-MMU-416476); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "1370937;30084848;34428180;8120392", "class_list": "", "function": "This gene encodes the receptor for the tachykinin, substance P, also referred to as neurokinin 1. This gene belongs to a gene family of tachykinin receptors which are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This receptor has been associated with nitric oxide formation, and it has been localized to cholinergic and nitrergic neurons as well as on smooth muscle cells. [provided by RefSeq, Mar 2010]., [RefSeq]; This is a receptor for the tachykinin neuropeptide substance P (PubMed:1370937). Is also able to bind and respond to tachynins neurokinin A/substance K and neurokinin B/neuromedin-K. The rank order of affinity of this receptor to tachykinins is: substance P > neurokinin A/substance K > neurokinin B/neuromedin-K. Substance P binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. Substance P binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYR7", "ec_number_list": "", "go_molecular_function": "GO:0016496 substance P receptor activity", "go_cellular_component": "GO:0061827 sperm head;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0035106 operant conditioning;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P30548-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30549-1", "uniprot_id": "NK2R_MOUSE", "mass": 43114.0, "length": 384, "protein_name": "Substance-K receptor", "gene_name": "Tacr2", "organism": "Mouse", "refseq_name": "substance-K receptor", "refseq_ac": "NP_033340", "gene_names_uniprotkb": "Tacr2; Tac2r", "gene_names_refseq": "Nk2r; Skr; Tac2r; Tacr2", "protein_names_uniprotkb": "Substance-K receptor; NK-2 receptor; NK-2R; Neurokinin A receptor; SKR; Tachykinin receptor 2", "protein_names_refseq": "7 transmembrane receptor; NK-2R; neurokinin A receptor; substance-K receptor; tachykinin NK-2 receptor", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); asthma (Disease Ontology:DOID:2841); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:21337); (R-MMU-380095); (R-MMU-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12773411;1370937;15084523;25428506;28585346;33427049", "class_list": "", "function": "Congenital ablation of Tacr2 reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis., [RefSeq, PubMed]; NK-1R and NK-2R have important but differential roles in the regulation of cutaneous inflammatory responses, [RefSeq, PubMed]; Receptor for the tachykinin substance K (neurokinin A), also able to bind and respond to tachynins substance P and neurokinin B/neuromedin-K (PubMed:1370937). The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P (PubMed:1370937). Substance K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (By similarity). Substance K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Tachykinin NK2 receptor genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function., [RefSeq, PubMed]; Tacr2 negatively regulated the expression of neuronal nitric oxide synthase (nNOS) and vasoactive intestinal polypeptide (VIP). Its ablation in mice elevated the expression of nNOS and VIP, enhanced nitric oxide signaling and changed the Creb and NF-kappaB signalings, finally leading to the gastric emptying disturbance of Tacr2(-/-) mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016497 substance K receptor activity", "go_cellular_component": "GO:0061827 sperm head;GO:0005886 plasma membrane;GO:0036126 sperm flagellum;GO:0097225 sperm midpiece", "go_biological_process": "GO:0035106 operant conditioning;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0043270 positive regulation of monoatomic ion transport;GO:0014057 positive regulation of acetylcholine secretion, neurotransmission;GO:0014827 intestine smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P30549-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35487-1", "uniprot_id": "ODPAT_MOUSE", "mass": 43413.0, "length": 391, "protein_name": "Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial", "gene_name": "Pdha2", "organism": "Mouse", "refseq_name": "pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor", "refseq_ac": "NP_032837", "gene_names_uniprotkb": "Pdha2; Pdha-2; Pdhal", "gene_names_refseq": "Pdha2; Pdhal", "protein_names_uniprotkb": "Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; 1.2.4.1; PDHE1-A type II", "protein_names_refseq": "PDHE1-A type II; PYRUVATE DEHYDROGENASE E1 COMPONENT ALPHA SUBUNIT, TESTIS-SPECIFIC FORM, MITOCHONDRIAL PRECURSOR (PDHE1-A TYPE II); pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); spermatogenic failure 70 (Disease Ontology:DOID:0070569); pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:18598); (R-MMU-204174); (R-MMU-5362517); (R-MMU-9861559)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "1581363;35820727", "class_list": "", "function": "Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex in testis. The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497M8", "ec_number_list": "1.8.1.4;2.7.11.2;2.7.11.-;1.2.4.1;3.1.3.43;2.3.1.12", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0032991 protein-containing complex;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006006 glucose metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35487-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42580-1", "uniprot_id": "NKX12_MOUSE", "mass": 32013.0, "length": 305, "protein_name": "NK1 transcription factor-related protein 2", "gene_name": "Nkx1-2", "organism": "Mouse", "refseq_name": "NK1 transcription factor-related protein 2", "refseq_ac": "NP_033149", "gene_names_uniprotkb": "Nkx1-2; Nkx1.1; Sax1", "gene_names_refseq": "Nkx-1.1; Nkx-1.2; Nkx1-2; Sax1", "protein_names_uniprotkb": "NK1 transcription factor-related protein 2; Homeobox protein SAX-1; NKX-1.1", "protein_names_refseq": "NK1 transcription factor related, locus 2; NK1 transcription factor-related protein 2; homeobox protein Nkx1.2E427; homeobox protein SAX-1; spinal cord axial homeobox gene 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20231)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10681422;31615896;38701778;7669696;9370304;9748262", "class_list": "", "function": "Results suggest a role for NK1 homeobox 2 (NKX1-2) in promoting adipogenesis and possibly in regulating the balance between adipocyte and osteoblast differentiation of bone marrow mesenchymal precursor cells., [RefSeq, PubMed]; The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development., [RefSeq, PubMed]; Transcriptional repressor (Probable). May play a role in early development as a Wnt/beta-catenin effector, hence controlling pluripotency and preimplantation development of embryonic stem cells (PubMed:38701778). May promote adipogenesis in mesenchymal stem cells, possibly by inhibiting the expression of the antiadipogenic factor NR2F2 (PubMed:31615896). May inhibit osteoblastogenic differentiation (PubMed:31615896)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4QPC3;Q9JHF2;Q9JKW5;Q9JKW6;Q9JKW9;Q9JKX0;Q9JKX1", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P42580-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P57774-1", "uniprot_id": "NPY_MOUSE", "mass": 10874.0, "length": 97, "protein_name": "Pro-neuropeptide Y", "gene_name": "Npy", "organism": "Mouse", "refseq_name": "pro-neuropeptide Y preproprotein", "refseq_ac": "NP_075945", "gene_names_uniprotkb": "Npy", "gene_names_refseq": "0710005A05Rik; Npy", "protein_names_uniprotkb": "Pro-neuropeptide Y; NPY; Neuropeptide tyrosine", "protein_names_refseq": "pro-neuropeptide Y preproprotein; pro-neuropeptide Y", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); peripheral artery disease (Disease Ontology:DOID:0050830); absence epilepsy (Disease Ontology:DOID:0070309); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Huntington's disease (Disease Ontology:DOID:12858); dementia (Disease Ontology:DOID:1307); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); anxiety disorder (Disease Ontology:DOID:2030); arteriosclerosis (Disease Ontology:DOID:2349); temporal lobe epilepsy (Disease Ontology:DOID:3328); cerebral infarction (Disease Ontology:DOID:3526); median neuropathy (Disease Ontology:DOID:571); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:109648); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11210195;16452087;21457230;30084848;34203471;37545877;8743297", "class_list": "", "function": "Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by NPY also leads to an increase of intracellular Ca(2+) levels. Is involved in the regulation of eating behaviour, acting as a stimulator of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (PubMed:21457230)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; This gene encodes a neuropeptide that plays a pivotal role in many physiological functions such as food intake, energy homeostasis, circadian rhythm, and cognition. The encoded protein precursor undergoes proteolytic processing to generate the biologically active peptide. Mice lacking the encoded protein exhibit mild seizures occasionally and become hyperphagic following food deprivation. A deficiency of the encoded protein partially prevents mice lacking leptin from becoming obese. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q925V2;Q9ET27", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity;GO:0031841 neuropeptide Y receptor binding;GO:0160041 neuropeptide activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0032100 positive regulation of appetite;GO:1904000 positive regulation of eating behavior;GO:0001878 response to yeast;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P57774-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P81117-1", "uniprot_id": "NUCB2_MOUSE", "mass": 50304.0, "length": 420, "protein_name": "Nucleobindin-2", "gene_name": "Nucb2", "organism": "Mouse", "refseq_name": "nucleobindin-2 precursor", "refseq_ac": "NP_001123951", "gene_names_uniprotkb": "Nucb2; Nefa", "gene_names_refseq": "Calnuc; Nefa; Nesfatin-1; Nucb2", "protein_names_uniprotkb": "Nucleobindin-2; DNA-binding protein NEFA; Prepronesfatin", "protein_names_refseq": "DNA-binding protein NEFA; nucleobindin-2 precursor; prepronefastin; prepronesfatin", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:53322)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10915798;18477467;19248766;21750661;22645316;23443134;34428180;36271663;36678225;37224650;37269882;37481139", "class_list": "", "function": "5-HT systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors, and induce anorexia via a leptin-independent pathway in mice., [RefSeq, PubMed]; Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Calcium-binding protein which may have a role in calcium homeostasis (PubMed:10915798). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G protein) alpha subunit GNAI3 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Does NUCB2/Nesfatin-1 Influence Eating Behaviors in Obese Patients with Binge Eating Disorder? Toward a Neurobiological Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Nesfatin-1 regulates steroidogenesis in mouse Leydig cells., [RefSeq, PubMed]; Nesfatin-1 stimulates BMP5 expression and osteoclastogenesis in rheumatoid arthritis., [RefSeq, PubMed]; Nesfatin-1, a novel energy-regulating peptide, alleviates pulmonary fibrosis by blocking TGF-beta1/Smad pathway in an AMPKalpha-dependent manner., [RefSeq, PubMed]; The protective effects of nesfatin-1 in neurological dysfunction after spinal cord injury by inhibiting neuroinflammation., [RefSeq, PubMed]; These results indicate that the insulin producing beta cells colocalize pronesfatin in the islets of both mice and rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005509 calcium ion binding;GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1901142 insulin metabolic process;GO:0006874 intracellular calcium ion homeostasis;GO:0007264 small GTPase-mediated signal transduction;GO:0045599 negative regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P81117-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97295-1", "uniprot_id": "NPY2R_MOUSE", "mass": 42628.0, "length": 381, "protein_name": "Neuropeptide Y receptor type 2", "gene_name": "Npy2r", "organism": "Mouse", "refseq_name": "neuropeptide Y receptor type 2 isoform 1", "refseq_ac": "NP_032757", "gene_names_uniprotkb": "Npy2r", "gene_names_refseq": "NPY2-R; Npy2r", "protein_names_uniprotkb": "Neuropeptide Y receptor type 2; NPY-Y2 receptor; NPY2-R; Y2 receptor", "protein_names_refseq": "NPY-Y2 receptor; Y2 receptor; neuropeptide Y receptor type 2 isoform 1; neuropeptide Y receptor type 2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); peripheral artery disease (Disease Ontology:DOID:0050830); morbid obesity (Disease Ontology:DOID:11981); Huntington's disease (Disease Ontology:DOID:12858); major depressive disorder (Disease Ontology:DOID:1470); temporal lobe epilepsy (Disease Ontology:DOID:3328); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:18167); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10436066;12167864;16280589;21457230;8914576", "class_list": "", "function": "Receptor for neuropeptide Y (NPY) and peptide YY (PYY) (PubMed:8914576). Can also bind with lower affinity pancreatic polypeptide (PP/PPY) and [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form (By similarity). NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels (PubMed:8914576). Involved in the regulation of colonic antisecretory tone, and colonic contractility (PubMed:21457230). As receptor for peptide PYY(3-36) in the arcuate nucleus of the hypothalamus, it is involved in the down-regulation of appetite and food intake (PubMed:12167864, PubMed:16280589)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F7C6W7;Q8BWV1", "ec_number_list": "", "go_molecular_function": "GO:0001965 G-protein alpha-subunit binding;GO:0008188 neuropeptide receptor activity;GO:0004983 neuropeptide Y receptor activity;GO:0001601 peptide YY receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0097730 non-motile cilium;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0003151 outflow tract morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97295-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97300-2", "uniprot_id": "NPTN_MOUSE", "mass": 44373.0, "length": 397, "protein_name": "Neuroplastin", "gene_name": "Nptn", "organism": "Mouse", "refseq_name": "neuroplastin isoform 2 precursor", "refseq_ac": "NP_001280602", "gene_names_uniprotkb": "Nptn; Sdfr1; Sdr1", "gene_names_refseq": "NP65; Nptn; SDR-1; Sdfr1", "protein_names_uniprotkb": "Neuroplastin; SDR-1; Stromal cell-derived receptor 1", "protein_names_refseq": "neuroplastin isoform 2 precursor; stromal cell derived factor receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20320)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;16944957;19349973;19656770;28827723;30899004;31219806;33300544;35822049;36007354;38203350;40836084;8938438", "class_list": "", "function": "Accessory subunit of plasma membrane calcium-transporting ATPase ATP2B2/PMCA2 that stabilizes the transporter at the cell surface (PubMed:40836084). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:28827723). Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK (By similarity). May also regulate neurite outgrowth by activating the FGFR1 signaling pathway (By similarity). May play a role in synaptic plasticity (By similarity). Promotes localization of XKR8 at the cell membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Neuroplastin Expression in Male Mice Is Essential for Fertility, Mating, and Adult Testosterone Levels. Publication Status: Online-Only, [RefSeq, PubMed]; The role of neuroplastin65 in macrophage against E. coli infection in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 27, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3U519;Q8C637;Q8C6H8", "ec_number_list": "", "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0044325 transmembrane transporter binding;GO:0050839 cell adhesion molecule binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0001934 positive regulation of protein phosphorylation;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008542 visual learning;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "P97300-2", "record_type": "protein" }, { "uniprot_canonical_ac": "P97463-1", "uniprot_id": "NRTN_MOUSE", "mass": 22219.0, "length": 195, "protein_name": "Neurturin", "gene_name": "Nrtn", "organism": "Mouse", "refseq_name": "neurturin preproprotein", "refseq_ac": "NP_032764", "gene_names_uniprotkb": "Nrtn", "gene_names_refseq": "NTN; Nrtn", "protein_names_uniprotkb": "Neurturin", "protein_names_refseq": "neurturin preproprotein", "tax_id": 10090, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487)", "pathway": " (mmu:18188); (R-MMU-5673001); (R-MMU-8853659)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "19176599;34592133;8945474", "class_list": "", "function": "Growth factor that supports the survival of sympathetic neurons in culture (PubMed:8945474). May regulate the development and maintenance of the CNS (PubMed:8945474). Involved in the development of the neural crest (By similarity). Might control the size of non-neuronal cell population such as haemopoietic cells (PubMed:8945474). Acts by binding to its coreceptor, GFRA2, leading to autophosphorylation and activation of the RET receptor (By similarity). Heparan sulfate-binding is required for signaling (By similarity)., [UniProtKB, UniProtKB, PubMed]; Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity., [RefSeq, PubMed]; Report structural and functional cardiac cholinergic deficits in adult neurturin knockout mice., [RefSeq, PubMed]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. Homozygous knockout mice for this gene exhibit defects in the development of the retina and enteric nervous system, and reduced cholinergic innervation of the heart and lacrimal glands. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1904399 heparan sulfate binding;GO:0030971 receptor tyrosine kinase binding;GO:0008083 growth factor activity;GO:0030116 glial cell-derived neurotrophic factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030424 axon", "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0031175 neuron projection development;GO:0001755 neural crest cell migration;GO:0021675 nerve development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97463-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04573-1", "uniprot_id": "NPY1R_MOUSE", "mass": 44015.0, "length": 382, "protein_name": "Neuropeptide Y receptor type 1", "gene_name": "Npy1r", "organism": "Mouse", "refseq_name": "neuropeptide Y receptor type 1", "refseq_ac": "NP_035064", "gene_names_uniprotkb": "Npy1r", "gene_names_refseq": "NPY1-R; Npy1r; Npyr; Y1-R", "protein_names_uniprotkb": "Neuropeptide Y receptor type 1; NPY1-R", "protein_names_refseq": "NPY-1 receptor; neuropeptide Y receptor subtype; neuropeptide Y receptor type 1", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); peripheral artery disease (Disease Ontology:DOID:0050830); stroke (Disease Ontology:DOID:0051061); absence epilepsy (Disease Ontology:DOID:0070309); hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); opiate dependence (Disease Ontology:DOID:2559); temporal lobe epilepsy (Disease Ontology:DOID:3328); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:18166); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;1468559;21183079;21457230;8530415;9623984", "class_list": "", "function": "Receptor for neuropeptide Y (NPY) and peptide YY (PYY). Can also bind with high affinity [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form, while having virtually no affinity for pancreatic polypeptide (PP/PPY) at physiological concentrations. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels. As a receptor for NPY, it is involved in the regulation of eating behaviour and NPY-induced stimulation of food intake (PubMed:9623984). Involved in the regulation of colonic antisecretory tone, and colonic contractility (PubMed:21457230)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q61993", "ec_number_list": "", "go_molecular_function": "GO:0004983 neuropeptide Y receptor activity;GO:0001601 peptide YY receptor activity;GO:0001602 pancreatic polypeptide receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043005 neuron projection", "go_biological_process": "GO:0030432 peristalsis;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007626 locomotory behavior;GO:0040014 regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q04573-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06219-1", "uniprot_id": "NR4A2_MOUSE", "mass": 66593.0, "length": 598, "protein_name": "Nuclear receptor subfamily 4 group A member 2", "gene_name": "Nr4a2", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 4 group A member 2 isoform a", "refseq_ac": "NP_001132981", "gene_names_uniprotkb": "Nr4a2; Nurr1", "gene_names_refseq": "HZF-3; NOT; Nr4a2; Nurr1; RNR-1; TINOR; TINUR", "protein_names_uniprotkb": "Nuclear receptor subfamily 4 group A member 2; NUR-related factor 1; Orphan nuclear receptor NURR1", "protein_names_refseq": "NUR-related factor 1; nuclear receptor subfamily 4 group A member 2 isoform a; nur related protein 1; orphan nuclear receptor NURR1", "tax_id": 10090, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:18227); (R-MMU-383280)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1491694;19144721;20159955;21750661;27802388;9143501", "class_list": "", "function": "Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed:19144721). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (PubMed:19144721)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08690", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0035259 nuclear glucocorticoid receptor binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06219-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TZX8-1", "uniprot_id": "NOL9_MOUSE", "mass": 80840.0, "length": 714, "protein_name": "Polynucleotide 5'-hydroxyl-kinase NOL9", "gene_name": "Nol9", "organism": "Mouse", "refseq_name": "polynucleotide 5'-hydroxyl-kinase NOL9 isoform 1", "refseq_ac": "NP_001153071", "gene_names_uniprotkb": "Nol9", "gene_names_refseq": "4632412I24Rik; 6030462G04Rik; Nol9", "protein_names_uniprotkb": "Polynucleotide 5'-hydroxyl-kinase NOL9; 2.7.1.78; Nucleolar protein 9", "protein_names_refseq": "polynucleotide 5'-hydroxyl-kinase NOL9 isoform 1; polynucleotide 5'-hydroxyl-kinase NOL9", "tax_id": 10090, "disease": "", "pathway": " (mmu:74035); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21183079;21750661;22872859;25153642;25428506;28528544;30084848;31219806;34428180;36210013", "class_list": "", "function": "Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (By similarity). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0PJC7;B1AS65;Q05A31;Q8BQE1;Q8C8L5;Q8C9A8;Q9D678", "ec_number_list": "3.1.-.-;3.1.13.-;2.7.1.78;3.1.13.1;3.1.26.-;3.6.4.13;3.4.22.-;3.1.3.32", "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0051736 ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0051731 polynucleotide 5'-hydroxyl-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0045111 intermediate filament cytoskeleton;GO:0120330 rixosome complex", "go_biological_process": "GO:0000460 maturation of 5.8S rRNA;GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3TZX8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U2V3-1", "uniprot_id": "NUD18_MOUSE", "mass": 35694.0, "length": 323, "protein_name": "8-oxo-dGDP phosphatase NUDT18", "gene_name": "Nudt18", "organism": "Mouse", "refseq_name": "8-oxo-dGDP phosphatase NUDT18 isoform 1", "refseq_ac": "NP_694776", "gene_names_uniprotkb": "Nudt18", "gene_names_refseq": "Nudt18", "protein_names_uniprotkb": "8-oxo-dGDP phosphatase NUDT18; 2-hydroxy-dADP phosphatase; 3.6.1.58; 3.6.1.68; 3.6.1.76; 7,8-dihydro-8-oxoguanine phosphatase; Nucleoside diphosphate-linked moiety X motif 18; Nudix motif 18", "protein_names_refseq": "2-hydroxy-dADP phosphatase; 7,8-dihydro-8-oxoguanine phosphatase; 8-oxo-dGDP phosphatase NUDT18 isoform 1; 8-oxo-dGDP phosphatase NUDT18; mutT homolog 3; nudix (nucleoside diphosphate linked moiety X)-type motif 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:213484); (R-MMU-2393930)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Also hydrolyzes 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. In vitro, it catalyzes the hydrolysis of isoprene pyrophosphates, including (2E)-geranyl diphosphate, isopentenyl diphosphate, (2E,6E)-farnesyl diphosphate and dimethylallyl diphosphate. It may therefore play a role in the control of cellular levels of these metabolites that are essential for multiple cellular processes, including isoprenoids synthesis and protein isoprenylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C223;Q8K1Y7", "ec_number_list": "3.6.1.58;3.6.1.68;3.6.1.76;3.6.1.9;3.6.1.-;3.1.3.-;3.6.1.13;2.7.7.96", "go_molecular_function": "GO:0044715 8-oxo-dGDP phosphatase activity;GO:0044716 8-oxo-GDP phosphatase activity;GO:0044717 8-hydroxy-dADP phosphatase activity;GO:0046872 metal ion binding;GO:0106405 isoprenoid diphosphate phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0046057 dADP catabolic process;GO:0046067 dGDP catabolic process;GO:0046712 GDP catabolic process;GO:0009117 nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3U2V3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UNA4-1", "uniprot_id": "NXT2_MOUSE", "mass": 16257.0, "length": 142, "protein_name": "NTF2-related export protein 2", "gene_name": "Nxt2", "organism": "Mouse", "refseq_name": "NTF2-related export protein 2 isoform a", "refseq_ac": "NP_001154902", "gene_names_uniprotkb": "Nxt2", "gene_names_refseq": "6330587F24Rik; Nxt2; P15-2", "protein_names_uniprotkb": "NTF2-related export protein 2", "protein_names_refseq": "NTF2-related export protein 2 isoform a; NTF2-related export protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:237082)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "30084848;35219094", "class_list": "", "function": "Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents., [RefSeq, PubMed]; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AVX3;B1AVX5;Q505F8;Q6NVE1;Q8C070", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0042272 nuclear RNA export factor complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UNA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UV55-1", "uniprot_id": "NR1D1_MOUSE", "mass": 66802.0, "length": 615, "protein_name": "Nuclear receptor subfamily 1 group D member 1", "gene_name": "Nr1d1", "organism": "Mouse", "refseq_name": "nuclear receptor subfamily 1 group D member 1", "refseq_ac": "NP_663409", "gene_names_uniprotkb": "Nr1d1; Ear1", "gene_names_refseq": "A530070C09Rik; Nr1d1", "protein_names_uniprotkb": "Nuclear receptor subfamily 1 group D member 1; EAR-1; Rev-erbA-alpha; V-erbA-related protein 1", "protein_names_refseq": "EAR-1; REV-ERBalpha; Rev-ErbA-alpha protein; V-erbA-related protein 1; nuclear receptor protein; nuclear receptor subfamily 1 group D member 1; orphan nuclear receptor; rev-erb alpha; rev-erbA alpha", "tax_id": 10090, "disease": "brain small vessel disease (Disease Ontology:DOID:0112313); portal hypertension (Disease Ontology:DOID:10762); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); hypothyroidism (Disease Ontology:DOID:1459); hyperthyroidism (Disease Ontology:DOID:7998); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:217166); (R-MMU-383280)", "pathway_count": 2, "publication_count": 39, "publication_id_list": "14645221;15591021;18227153;18454201;18565334;19710360;19721697;20159955;20534529;21408158;21874017;22166979;22170608;22184247;22474260;22549838;23201262;23398316;23531614;23728303;23852339;23936124;24030830;24162845;24603368;24794873;25212631;25428506;27238018;27686098;29508494;29533925;29653076;29937374;30096135;30555544;30792350;31748741;9405624", "class_list": "", "function": "This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Feb 2014]., [RefSeq]; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (PubMed:30555544). Represses the transcription of CES2 (PubMed:29653076). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (PubMed:24794873). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (PubMed:27686098). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (PubMed:29533925). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (PubMed:30792350). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (PubMed:30096135)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJJ1;Q62171;Q6EEZ6;Q922A5;Q9ESY4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:1903979 negative regulation of microglial cell activation;GO:0060086 circadian temperature homeostasis;GO:0070859 positive regulation of bile acid biosynthetic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q3UV55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4FZG9-1", "uniprot_id": "CX4L2_MOUSE", "mass": 10046.0, "length": 87, "protein_name": "Cytochrome c oxidase hypoxia associated subunit FA4L2", "gene_name": "Coxfa4l2", "organism": "Mouse", "refseq_name": "cytochrome c oxidase hypoxia associated subunit FA4L2", "refseq_ac": "NP_001092259", "gene_names_uniprotkb": "Coxfa4l2; Ndufa4l2", "gene_names_refseq": "Coxfa4l2; Ndufa4l2", "protein_names_uniprotkb": "Cytochrome c oxidase hypoxia associated subunit FA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2; Ndufa4, mitochondrial complex associated like 2; cytochrome c oxidase hypoxia associated subunit FA4L2", "tax_id": 10090, "disease": "", "pathway": " (mmu:407790)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22100406;31740659;34428180;34724256;35929074;37558878", "class_list": "", "function": "Induction of the mitochondrial NDUFA4L2 protein by HIF-1alpha decreases oxygen consumption by inhibiting Complex I activity., [RefSeq, PubMed]; Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force., [RefSeq, PubMed]; Mitochondrial protein that plays a regulatory role in cellular metabolism, particularly under hypoxic conditions (PubMed:22100406, PubMed:34724256). Downregulates mitochondrial respiratory chain complex I activity under hypoxia, reduces oxygen consumption and ROS (PubMed:22100406, PubMed:34724256, PubMed:37558878)., [UniProtKB, PubMed, PubMed, PubMed]; The results demonstrated that the upregulation of NDUFA4L2 ameliorated the apoptosis of NP cells by repressing excessive mitophagy, which ultimately alleviated IVDD. These findings show for the first time that NDUFA4L2 and mitophagy may be potential therapeutic targets for IVDD. Publication Status: Online-Only, [RefSeq, PubMed]; Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0001666 response to hypoxia;GO:0071456 cellular response to hypoxia;GO:1902957 negative regulation of mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q4FZG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5HZK2-1", "uniprot_id": "NRSN2_MOUSE", "mass": 22415.0, "length": 202, "protein_name": "Neurensin-2", "gene_name": "Nrsn2", "organism": "Mouse", "refseq_name": "neurensin-2 isoform 1", "refseq_ac": "NP_001009948", "gene_names_uniprotkb": "Nrsn2; Gm123", "gene_names_refseq": "Gm123; Neurensin-2; Nrsn2", "protein_names_uniprotkb": "Neurensin-2", "protein_names_refseq": "neurensin-2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:228777)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;16527258;33723417;35820727", "class_list": "", "function": "Activation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin interneurons mediates the response to chronic antidepressants., [RefSeq, PubMed]; May play a role in maintenance and/or transport of vesicles., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AS81;Q3USR0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0031410 cytoplasmic vesicle;GO:0043005 neuron projection;GO:0030133 transport vesicle", "go_biological_process": "GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5HZK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SZA1-1", "uniprot_id": "NPT3_MOUSE", "mass": 51965.0, "length": 478, "protein_name": "Sodium-dependent phosphate transport protein 3", "gene_name": "Slc17a2", "organism": "Mouse", "refseq_name": "sodium-dependent phosphate transport protein 3 isoform 2", "refseq_ac": "NP_659085", "gene_names_uniprotkb": "Slc17a2; Npt3", "gene_names_refseq": "C730032N17Rik; NPT3; Slc17a2", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 3; Na(+)/PI cotransporter 3; Sodium/phosphate cotransporter 3; Solute carrier family 17 member 2", "protein_names_refseq": "Na(+)/PI cotransporter 3; sodium-dependent phosphate transport protein 3 isoform 2; sodium-dependent phosphate transport protein 3; sodium/phosphate cotransporter 3; solute carrier family 17 member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:218103)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25972451;34428180", "class_list": "", "function": "Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions (PubMed:25972451). Mediates chloride-dependent transport of urate (PubMed:25972451). Can actively transport inorganic phosphate into cells via Na(+) cotransport (PubMed:25972451)., [UniProtKB, PubMed]; Suggest that murine NPT3 is a polyspecific organic anion transporter that is involved in circulation of urate throughout the body., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCX8", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015293 symporter activity;GO:0015143 urate transmembrane transporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SZA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60878-1", "uniprot_id": "O4C3D_MOUSE", "mass": 33734.0, "length": 302, "protein_name": "Olfactory receptor 4C3D", "gene_name": "Or4c3d", "organism": "Mouse", "refseq_name": "olfactory receptor 4C3D", "refseq_ac": "NP_065261", "gene_names_uniprotkb": "Or4c3d; Mor235-1; Olfr140; Olfr4", "gene_names_refseq": "A16; MOR235-1; Olfr140; Or4c3d; Ora16", "protein_names_uniprotkb": "Olfactory receptor 4C3D; Odorant receptor A16; Olfactory receptor 140; Olfactory receptor 235-1; Olfactory receptor 4A", "protein_names_refseq": "GA_x6K02T2Q125-51484508-51483600; odorant receptor A16; olfactory receptor 140; olfactory receptor 235-1; olfactory receptor 4A; olfactory receptor 4C3D", "tax_id": 10090, "disease": "", "pathway": " (mmu:57272)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10493742;8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0K1", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q60878-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60891-1", "uniprot_id": "O3A10_MOUSE", "mass": 34425.0, "length": 315, "protein_name": "Olfactory receptor 3A10", "gene_name": "Or3a10", "organism": "Mouse", "refseq_name": "olfactory receptor 3A10", "refseq_ac": "NP_667214", "gene_names_uniprotkb": "Or3a10; Mor255-2; Olfr139; Olfr1", "gene_names_refseq": "M5; MOR255-2; Olfr139; Or3a10", "protein_names_uniprotkb": "Olfactory receptor 3A10; Odorant receptor M5; Olfactory receptor 139; Olfactory receptor 1; Olfactory receptor 255-2", "protein_names_refseq": "GA_x6K02T2P1NL-4202012-4201065; odorant receptor M5; olfactory receptor 139; olfactory receptor 1; olfactory receptor 255-2; olfactory receptor 3A10; olfactory receptor MOR255-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:259005)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11170746;8570653", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VGR1;Q9EPY8", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q60891-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61982-1", "uniprot_id": "NOTC3_MOUSE", "mass": 244248.0, "length": 2318, "protein_name": "Neurogenic locus notch homolog protein 3", "gene_name": "Notch3", "organism": "Mouse", "refseq_name": "neurogenic locus notch homolog protein 3 precursor", "refseq_ac": "NP_032742", "gene_names_uniprotkb": "Notch3", "gene_names_refseq": "N3; Notch3; hpbk", "protein_names_uniprotkb": "Neurogenic locus notch homolog protein 3; Notch 3", "protein_names_refseq": "neurogenic locus notch homolog protein 3 precursor; neurogenic locus notch homolog protein 3", "tax_id": 10090, "disease": "autosomal recessive cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1 (Disease Ontology:DOID:0061227); familial partial lipodystrophy type 1 (Disease Ontology:DOID:0070207); infantile myofibromatosis 2 (Disease Ontology:DOID:0070667); autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1 (Disease Ontology:DOID:0111035); lateral meningocele syndrome (Disease Ontology:DOID:0111343); intestinal cancer (Disease Ontology:DOID:10155); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); brain cancer (Disease Ontology:DOID:1319); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); adenocarcinoma (Disease Ontology:DOID:299); central nervous system cancer (Disease Ontology:DOID:3620); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18131); (R-MMU-1912420); (R-MMU-350054); (R-MMU-9013507); (R-MMU-9017802)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11459941;11518718;15019995;17573339;18299578;21750661;26495903;28011936;30084848;30779550;34678516;35984892;40885482;7918097", "class_list": "", "function": "Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 16, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0014016 neuroblast differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q61982-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6T3U4-1", "uniprot_id": "NPCL1_MOUSE", "mass": 147132.0, "length": 1333, "protein_name": "NPC1-like intracellular cholesterol transporter 1", "gene_name": "Npc1l1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Npc1l1", "gene_names_refseq": "", "protein_names_uniprotkb": "NPC1-like intracellular cholesterol transporter 1; Niemann-Pick C1-like protein 1; Npc1l1", "protein_names_refseq": "", "tax_id": 10090, "disease": "Niemann-Pick disease type C1 (Disease Ontology:DOID:0070113); Niemann-Pick disease (Disease Ontology:DOID:14504)", "pathway": " (mmu:237636); (R-MMU-8963678)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;14976318;15173162;15604518;15671032;21750661;25428506;29880681;30084848", "class_list": "", "function": "Plays a major role in cholesterol homeostasis (PubMed:14976318, PubMed:15173162, PubMed:15671032). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:15173162, PubMed:15671032). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (PubMed:15173162). May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation (PubMed:15671032). May be involved in caveolin trafficking from the plasma membrane (PubMed:15671032). Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5SVX1", "ec_number_list": "", "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0042803 protein homodimerization activity;GO:0015485 cholesterol binding;GO:0031267 small GTPase binding;GO:0008431 vitamin E binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0071501 cellular response to sterol depletion;GO:0042157 lipoprotein metabolic process;GO:0006695 cholesterol biosynthetic process;GO:0030299 intestinal cholesterol absorption;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6T3U4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJW5-1", "uniprot_id": "NOL11_MOUSE", "mass": 80818.0, "length": 723, "protein_name": "Nucleolar protein 11", "gene_name": "Nol11", "organism": "Mouse", "refseq_name": "nucleolar protein 11 isoform 2", "refseq_ac": "NP_001154801", "gene_names_uniprotkb": "Nol11", "gene_names_refseq": "1500002M01Rik; Nol11", "protein_names_uniprotkb": "Nucleolar protein 11", "protein_names_refseq": "nucleolar protein 11 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68979); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "18299400;19892989;20173027;20484733;21952136;22872234;25428507;31219806;34428180;35820727;36210013", "class_list": "", "function": "Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGJ1;Q8R3Q3;Q99KA5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0034455 t-UTP complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BJW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BY02-1", "uniprot_id": "NKRF_MOUSE", "mass": 77739.0, "length": 690, "protein_name": "NF-kappa-B-repressing factor", "gene_name": "Nkrf", "organism": "Mouse", "refseq_name": "NF-kappa-B-repressing factor", "refseq_ac": "NP_084167", "gene_names_uniprotkb": "Nkrf; Nrf", "gene_names_refseq": "9430034D17Rik; Nkrf", "protein_names_uniprotkb": "NF-kappa-B-repressing factor; NFkB-repressing factor; Transcription factor NRF", "protein_names_refseq": "NF-kappa-B-repressing factor; NFkB-repressing factor; transcription factor NRF", "tax_id": 10090, "disease": "", "pathway": " (mmu:77286)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17592041;21750661;25277410;37667861", "class_list": "", "function": "Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MIR29 targets and reduces expression of CLDN1 and NKRF to increase intestinal permeability in inflammatory bowel disease., [RefSeq, PubMed]; NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post-Myocardial Infarction via Human Antigen R., [RefSeq, PubMed]; The data of this study show that JKTBP1 and the 14-nt element act independently to mediate NRF internal ribosome entry segment activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A3V7;Q8BJU5;Q9CRL2", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001671 ATPase activator activity;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BY02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3Z0-1", "uniprot_id": "NOD2_MOUSE", "mass": 113562.0, "length": 1020, "protein_name": "Nucleotide-binding oligomerization domain-containing protein 2", "gene_name": "Nod2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nod2; Card15", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15", "protein_names_refseq": "", "tax_id": 10090, "disease": "Blau syndrome (Disease Ontology:DOID:0050678); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); gastrointestinal carcinoma (Disease Ontology:DOID:0050922); colitis (Disease Ontology:DOID:0060180); meningococcal meningitis (Disease Ontology:DOID:0080176); graft-versus-host disease (Disease Ontology:DOID:0081267); PFAPA syndrome (Disease Ontology:DOID:0081451); inflammatory bowel disease 1 (Disease Ontology:DOID:0110892); leprosy (Disease Ontology:DOID:1024); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); pulmonary sarcoidosis (Disease Ontology:DOID:13406); breast cancer (Disease Ontology:DOID:1612); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); larynx cancer (Disease Ontology:DOID:2596); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); gastritis (Disease Ontology:DOID:4029); autoimmune disease (Disease Ontology:DOID:417); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); pancreatitis (Disease Ontology:DOID:4989); intestinal disease (Disease Ontology:DOID:5295); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (R-MMU-168638); (R-MMU-450302); (R-MMU-450321); (R-MMU-5689896)", "pathway_count": 4, "publication_count": 28, "publication_id_list": "12835899;15692051;15692052;16203728;17187069;18511561;19805227;19898471;19966812;21421666;21715553;21856952;22607974;23019338;23281400;24062413;24882705;25088769;25429073;25666722;27007849;27230380;28127403;31919280;34428180;35420957;36002575;36821686", "class_list": "", "function": "Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and plays an important role in gastrointestinal immunity (PubMed:15692051, PubMed:15692052, PubMed:19805227, PubMed:21715553). Specifically activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan found in every bacterial peptidoglycan type (PubMed:15692051, PubMed:15692052, PubMed:25429073). NOD2 specifically recognizes and binds 6-O-phospho-MDP, the phosphorylated form of MDP, which is generated by NAGK (PubMed:36002575). 6-O-phospho-MDP-binding triggers oligomerization that facilitates the binding and subsequent activation of the proximal adapter receptor-interacting RIPK2 (PubMed:15692051, PubMed:15692052, PubMed:22607974). Following recruitment, RIPK2 undergoes 'Met-1'- (linear) and 'Lys-63'-linked polyubiquitination by E3 ubiquitin-protein ligases XIAP, BIRC2, BIRC3 and the LUBAC complex, becoming a scaffolding protein for downstream effectors, triggering activation of the NF-kappa-B and MAP kinases signaling (PubMed:15692051, PubMed:15692052, PubMed:22607974). This in turn leads to the transcriptional activation of hundreds of genes involved in immune response (PubMed:22607974). Its ability to detect bacterial MDP plays a central role in maintaining the equilibrium between intestinal microbiota and host immune responses to control inflammation (PubMed:19805227, PubMed:21421666, PubMed:23281400, PubMed:24062413, PubMed:24882705, PubMed:25088769, PubMed:25666722, PubMed:28127403). An imbalance in this relationship results in dysbiosis, whereby pathogenic bacteria prevail on commensals, causing damage in the intestinal epithelial barrier as well as allowing bacterial invasion and inflammation (PubMed:23281400, PubMed:25088769). Acts as a regulator of appetite by sensing MDP in a subset of brain neurons: microbiota-derived MDP reach the brain, where they bind and activate NOD2 in inhibitory hypothalamic neurons, decreasing neuronal activity, thereby regulating satiety and body temperature (PubMed:35420957). NOD2-dependent MDP-sensing of bacterial cell walls in the intestinal epithelial compartment contributes to sustained postnatal growth upon undernutrition (PubMed:36821686). Also plays a role in antiviral response by acting as a sensor of single-stranded RNA (ssRNA) from viruses: upon ssRNA-binding, interacts with MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (By similarity). Also acts as a regulator of autophagy in dendritic cells via its interaction with ATG16L1, possibly by recruiting ATG16L1 at the site of bacterial entry (PubMed:19898471, PubMed:19966812, PubMed:27230380). NOD2 activation in the small intestine crypt also contributes to intestinal stem cells survival and function: acts by promoting mitophagy via its association with ATG16L1 (PubMed:31919280). In addition to its main role in innate immunity, also regulates the adaptive immune system by acting as regulator of helper T-cell and regulatory T-cells (Tregs) (PubMed:21856952, PubMed:27230380). Besides recognizing pathogens, also involved in the endoplasmic reticulum stress response: acts by sensing and binding to the cytosolic metabolite sphingosine-1-phosphate generated in response to endoplasmic reticulum stress, initiating an inflammation process that leads to activation of the NF-kappa-B and MAP kinases signaling (PubMed:27007849). May also be involved in NLRP1 activation following activation by MDP, leading to CASP1 activation and IL1B release in macrophages (PubMed:18511561)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0003779 actin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0097039 protein linear polyubiquitination;GO:0032701 negative regulation of interleukin-18 production;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0002710 negative regulation of T cell mediated immunity;GO:0002221 pattern recognition receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q8K3Z0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R5F3-1", "uniprot_id": "OARD1_MOUSE", "mass": 17107.0, "length": 152, "protein_name": "ADP-ribose glycohydrolase OARD1", "gene_name": "Oard1", "organism": "Mouse", "refseq_name": "ADP-ribose glycohydrolase OARD1 isoform 1", "refseq_ac": "NP_001276419", "gene_names_uniprotkb": "Oard1", "gene_names_refseq": "Oard1", "protein_names_uniprotkb": "ADP-ribose glycohydrolase OARD1; 3.2.2.-; 3.5.1.-; O-acetyl-ADP-ribose deacetylase 1; Terminal ADP-ribose protein glycohydrolase 1; [Protein ADP-ribosylglutamate] hydrolase OARD1", "protein_names_refseq": "ADP-ribose glycohydrolase OARD1 isoform 1; ADP-ribose glycohydrolase OARD1; O-acetyl-ADP-ribose deacetylase 1; [Protein ADP-ribosylglutamate] hydrolase OARD1; terminal ADP-ribose protein glycohydrolase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:106821)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U5M3", "ec_number_list": "3.2.2.19;3.5.1.-;3.2.2.-;3.2.1.143;3.1.1.106", "go_molecular_function": "GO:0001883 purine nucleoside binding;GO:0061463 O-acetyl-ADP-ribose deacetylase activity;GO:0140293 ADP-ribosylglutamate hydrolase activity;GO:0047407 ADP-ribosyl-[dinitrogen reductase] hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006974 DNA damage response;GO:0051725 protein de-ADP-ribosylation;GO:0042278 purine nucleoside metabolic process;GO:0140291 peptidyl-glutamate ADP-deribosylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R5F3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R5K4-1", "uniprot_id": "NOL6_MOUSE", "mass": 129228.0, "length": 1152, "protein_name": "Nucleolar protein 6", "gene_name": "Nol6", "organism": "Mouse", "refseq_name": "nucleolar protein 6", "refseq_ac": "NP_631982", "gene_names_uniprotkb": "Nol6", "gene_names_refseq": "Nol6; Nrap", "protein_names_uniprotkb": "Nucleolar protein 6; Nrap; Nucleolar RNA-associated protein", "protein_names_refseq": "nucleolar protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:230082); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11895476;12692149;18615632;18792955;19892989;21952136;22872234;25428506;25605945;30084848;30779550;31219806;34428180;36210013", "class_list": "", "function": "N-RAP-s is the predominant spliced form of N-RAP present throughout skeletal muscle development., [RefSeq, PubMed]; Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]; The results show that NMHC IIB knockdown led to decreased N-RAP levels through proteasome-mediated degradation., [RefSeq, PubMed]; Three new N-RAP binding partners: alpha-actinin, filamin-2, and Krp1 (also called sarcosin) in myofibril assembly, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TL75;Q3U1P8;Q6PAN8;Q8C6V4;Q8R5K3;Q8VCG0;Q8WTY7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006409 tRNA export from nucleus;GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8R5K4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VBV9-1", "uniprot_id": "O51E2_MOUSE", "mass": 35578.0, "length": 320, "protein_name": "Olfactory receptor 51E2", "gene_name": "Or51e2", "organism": "Mouse", "refseq_name": "olfactory receptor 51E2", "refseq_ac": "NP_001161975", "gene_names_uniprotkb": "Or51e2; Mol2.3; Olfr78; Psgr", "gene_names_refseq": "4633402A21Rik; MOL2.3; MOR18-2; Olfr78; Or51e2; PSGR; RA1c", "protein_names_uniprotkb": "Olfactory receptor 51E2; Olfactory receptor 78", "protein_names_refseq": "GA_x6K02T2PBJ9-5459657-5458695; olfactory receptor 51E2; olfactory receptor 78; olfactory receptor MOR18-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:170639); (R-MMU-381753)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11069588;11707321;23401498;26560302;30258151;30258152;34428180;38177905", "class_list": "", "function": "Olfactory receptor. The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), cAMP and activation of phosphorylation of the protein kinases PKA and MAPK3/MAPK1. Activation of OR51E2 may affect melanocyte proliferation, differentiation, and melanogenesis and may increase proliferation and migration of primary retinal pigment epithelial (RPE) cells (By similarity). Activated by the short chain fatty acids (SCFA), acetate and propionate (PubMed:23401498). In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (By similarity). Activated by L-lactate in glomus cells (PubMed:26560302, PubMed:30258151)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; The olfactory receptor Olfr78 promotes differentiation of enterochromaffin cells in the mouse colon., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0003707 nuclear steroid receptor activity;GO:0004984 olfactory receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:1900135 positive regulation of renin secretion into blood stream;GO:0097325 melanocyte proliferation;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VBV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC33-1", "uniprot_id": "NXNL1_MOUSE", "mass": 24912.0, "length": 217, "protein_name": "Nucleoredoxin-like protein 1", "gene_name": "Nxnl1", "organism": "Mouse", "refseq_name": "nucleoredoxin-like protein 1 isoform RdCVFL", "refseq_ac": "NP_663573", "gene_names_uniprotkb": "Nxnl1; Rdcvf; Txnl6", "gene_names_refseq": "A930031O08Rik; Nxnl1; RdCVF; Txnl6", "protein_names_uniprotkb": "Nucleoredoxin-like protein 1; RdCVF; Rod-derived cone viability factor; Thioredoxin-like protein 6", "protein_names_refseq": "nucleoredoxin-like protein 1 isoform RdCVFL; nucleoredoxin-like protein 1; rod-derived cone viability factor; thioredoxin-like 6; thioredoxin-like protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:234404)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15220920;19279044;19843539;20139892;25415434;25596499;25957687;27025156;33109704;34932831", "class_list": "", "function": "Functional interaction between RdCVFL and TAU described here is the first characterization of the RdCVFL signaling pathway involved in neuronal cell death mediated by oxidative stress, [RefSeq, PubMed]; NXNL1 negatively regulates osteoblast differentiation via GDF15-induced PP2A Calpha dependent manner in MC3T3-E1 cells., [RefSeq, PubMed]; Plays an important role in retinal cone photoreceptor survival (PubMed:25957687, PubMed:25415434). In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (PubMed:15220920)., [UniProtKB, PubMed, PubMed, PubMed]; RdCVFL is a cell-autonomous mechanism of protection., [RefSeq, PubMed]; Study shows that RdCVF acts through binding to Basigin-1 (BSG1), a transmembrane protein expressed specifically by photoreceptors. BSG1 binds to the glucose transporter GLUT1, resulting in increased glucose entry into cones., [RefSeq, PubMed]; The Nxnl1 gene, through the thioredoxin RdCVF-long isoform, is part of an endogenous defense mechanism against photooxidative stress., [RefSeq, PubMed]; Thioredoxin-like protein that protects retinal rod and cone photoreceptors against oxidative stress and photo-oxidative damage (PubMed:20139892, PubMed:25415434, PubMed:25596499, PubMed:27025156). Plays a role in the inhibition of TAU phosphorylation and protects TAU against oxidative stress in the retina (PubMed:19279044, PubMed:25596499). Acts as a reducing system for MSRA, facilitating the repair of oxidized proteins such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS) in the lens during oxidative stress conditions (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91W38", "ec_number_list": "", "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045494 photoreceptor cell maintenance;GO:0045454 cell redox homeostasis;GO:0080183 response to photooxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VC33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFD0-1", "uniprot_id": "O5P62_MOUSE", "mass": 35207.0, "length": 314, "protein_name": "Olfactory receptor 5P62", "gene_name": "Or5p62", "organism": "Mouse", "refseq_name": "olfactory receptor 5P62", "refseq_ac": "NP_666707", "gene_names_uniprotkb": "Or5p62; Mor204-19; Olfr486", "gene_names_refseq": "MOR204-19; Olfr486; Or5p62", "protein_names_uniprotkb": "Olfactory receptor 5P62; Olfactory receptor 204-19; Olfactory receptor 486", "protein_names_refseq": "GA_x6K02T2PBJ9-10501920-10500976; olfactory receptor 204-19; olfactory receptor 486; olfactory receptor 5P62; olfactory receptor MOR204-19", "tax_id": 10090, "disease": "", "pathway": " (mmu:258489)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VFD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFD3-1", "uniprot_id": "O5P60_MOUSE", "mass": 35724.0, "length": 321, "protein_name": "Olfactory receptor 5P60", "gene_name": "Or5p60", "organism": "Mouse", "refseq_name": "olfactory receptor 5P60", "refseq_ac": "NP_666710", "gene_names_uniprotkb": "Or5p60; Mor204-16; Olfr484", "gene_names_refseq": "MOR204-16; Olfr484; Or5p60", "protein_names_uniprotkb": "Olfactory receptor 5P60; Olfactory receptor 204-16; Olfactory receptor 484", "protein_names_refseq": "GA_x6K02T2PBJ9-10454128-10453163; olfactory receptor 204-16; olfactory receptor 484; olfactory receptor 5P60; olfactory receptor MOR204-16", "tax_id": 10090, "disease": "", "pathway": " (mmu:258492)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VFD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VFX2-1", "uniprot_id": "O5B21_MOUSE", "mass": 35485.0, "length": 319, "protein_name": "Olfactory receptor 5B21", "gene_name": "Or5b21", "organism": "Mouse", "refseq_name": "olfactory receptor 5B21", "refseq_ac": "NP_666913", "gene_names_uniprotkb": "Or5b21; Mor202-4; Olfr1444", "gene_names_refseq": "MOR202-4; Olfr1444; Or5b21", "protein_names_uniprotkb": "Olfactory receptor 5B21; Olfactory receptor 1444; Olfactory receptor 202-4", "protein_names_refseq": "GA_x6K02T2RE5P-3191201-3192160; olfactory receptor 1444; olfactory receptor 202-4; olfactory receptor 5B21; olfactory receptor MOR202-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:258697)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VFX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VG04-1", "uniprot_id": "OR5P6_MOUSE", "mass": 34940.0, "length": 314, "protein_name": "Olfactory receptor 5P6", "gene_name": "Or5p6", "organism": "Mouse", "refseq_name": "olfactory receptor 5P6", "refseq_ac": "NP_666945", "gene_names_uniprotkb": "Or5p6; Mor204-13; Olfr478", "gene_names_refseq": "GA_x6K02T2PBJ9-10361879-10360935; MOR204-13; Olfr478; Or5p6", "protein_names_uniprotkb": "Olfactory receptor 5P6; Olfactory receptor 204-13; Olfactory receptor 478", "protein_names_refseq": "olfactory receptor 204-13; olfactory receptor 478; olfactory receptor 5P6; olfactory receptor MOR204-13", "tax_id": 10090, "disease": "", "pathway": " (mmu:258729)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35820727", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VG04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VG05-1", "uniprot_id": "O5P59_MOUSE", "mass": 34774.0, "length": 315, "protein_name": "Olfactory receptor 5P59", "gene_name": "Or5p59", "organism": "Mouse", "refseq_name": "olfactory receptor 5P59", "refseq_ac": "NP_666946", "gene_names_uniprotkb": "Or5p59; Mor204-12; Olfr483", "gene_names_refseq": "MOR204-12; Olfr483; Or5p59", "protein_names_uniprotkb": "Olfactory receptor 5P59; Olfactory receptor 204-12; Olfactory receptor 483", "protein_names_refseq": "GA_x6K02T2PBJ9-10432095-10433042; olfactory receptor 204-12; olfactory receptor 483; olfactory receptor 5P59; olfactory receptor MOR204-12", "tax_id": 10090, "disease": "", "pathway": " (mmu:258730)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Potential odorant receptor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VG05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924H0-1", "uniprot_id": "NPFF2_MOUSE", "mass": 47449.0, "length": 417, "protein_name": "Neuropeptide FF receptor 2", "gene_name": "Npffr2", "organism": "Mouse", "refseq_name": "neuropeptide FF receptor 2", "refseq_ac": "NP_573455", "gene_names_uniprotkb": "Npffr2; Gpr74; Npff2", "gene_names_refseq": "Gpr74; HG31; NPFF2; Npffr2", "protein_names_uniprotkb": "Neuropeptide FF receptor 2; G protein-coupled receptor 74; Neuropeptide NPFF receptor", "protein_names_refseq": "G-protein coupled receptor 74; neuropeptide FF receptor 2; neuropeptide NPFF receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:104443); (R-MMU-389397); (R-MMU-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "14696013;17157836;19944730;30084848;38301284", "class_list": "", "function": "Hypothalamic NPFFR2 attenuates central insulin signaling and its knockout diminishes metabolic dysfunction in mouse models of diabetes mellitus., [RefSeq, PubMed]; NPFF system may also have species-specific features since the NPFF2 receptor mRNA expression differs from that reported for rat, [RefSeq, PubMed]; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB, UniProtKB]; Species-related differences in the binding properties of NPFF(2) receptors, [RefSeq, PubMed]; The distribution pattern of NPFF2 receptors in the diencephalon and the superficial layers of the spinal cord is consistent with a hypothesized potential role for NPFF in the modulation of sensory input and opioid analgesia., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKR6", "ec_number_list": "", "go_molecular_function": "GO:0031628 opioid receptor binding;GO:0004930 G protein-coupled receptor activity;GO:0008188 neuropeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0032870 cellular response to hormone stimulus;GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q924H0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99PA5-1", "uniprot_id": "NKG7_MOUSE", "mass": 17958.0, "length": 165, "protein_name": "Protein NKG7", "gene_name": "Nkg7", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nkg7", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein NKG7; Natural killer cell protein 7", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "11290961;32839608;33911019", "class_list": "", "function": "Regulates cytotoxic granule exocytosis in effector lymphocytes, thus acting as a critical mediator of inflammation in a broad range of infectious and non-infectious diseases (PubMed:32839608). Essential for cytotoxic degranulation of natural killer (NK) cells and CD8(+) T-cells and for the activation of CD4(+) T-cells following infection (PubMed:32839608). Plays a critical role in CD8(+) T-cell and NK cell-mediated cytolysis of target cells and contributes to the cytolytic activity via the perforin/granzyme pathway by enhancing exocytosis of LAMP1-carrying lytic granules (PubMed:32839608, PubMed:33911019). Contributes to NK cell-mediated control of cancer metastasis (PubMed:32839608)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0044194 cytolytic granule;GO:0101004 cytolytic granule membrane", "go_biological_process": "GO:0035710 CD4-positive, alpha-beta T cell activation;GO:0006954 inflammatory response;GO:0050729 positive regulation of inflammatory response;GO:0031640 killing of cells of another organism;GO:0042832 defense response to protozoan", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99PA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D531-3", "uniprot_id": "NXNL2_MOUSE", "mass": 17620.0, "length": 156, "protein_name": "Nucleoredoxin-like protein 2", "gene_name": "Nxnl2", "organism": "Mouse", "refseq_name": "nucleoredoxin-like protein 2", "refseq_ac": "NP_083449", "gene_names_uniprotkb": "Nxnl2", "gene_names_refseq": "4930519N16Rik; Nxnl2; Rdcvf2", "protein_names_uniprotkb": "Nucleoredoxin-like protein 2; RdCVF2; Rod-derived cone viability factor 2", "protein_names_refseq": "nucleoredoxin-like protein 2; rod-derived cone viability factor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:75124)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17764561;20949100;22343139", "class_list": "", "function": "May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons. In the retina, isoform 1 may be required for rod function and isoform 2 for cone viability and function., [UniProtKB, PubMed]; RdCVF2 shares many similarities with Rod-derived Cone Viability Factor in terms of gene structure, expression in a rod-dependent manner and protein 3D structure. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of the Nucleoredoxin-like genes involves a CRX responsive element that can act as both as a positive regulator of promoter activity and as a modulator of cell-type specificity Publication Status: Online-Only, [RefSeq, PubMed]; This study shows that Nxnl2 is a bi-functional gene involved in the maintenance of both the function and the viability of sensory neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91WB0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D531-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESQ8-1", "uniprot_id": "NPVF_MOUSE", "mass": 21065.0, "length": 188, "protein_name": "Pro-FMRFamide-related neuropeptide VF", "gene_name": "Npvf", "organism": "Mouse", "refseq_name": "pro-FMRFamide-related neuropeptide VF precursor", "refseq_ac": "NP_068692", "gene_names_uniprotkb": "Npvf; Rfrp", "gene_names_refseq": "Npvf; Rfrp", "protein_names_uniprotkb": "Pro-FMRFamide-related neuropeptide VF; FMRFamide-related peptides; Neuropeptide RFRP-2", "protein_names_refseq": "FMRFamide-related peptides; RFamide-related peptide; pro-FMRFamide-related neuropeptide VF precursor; pro-FMRFamide-related neuropeptide VF", "tax_id": 10090, "disease": "", "pathway": " (mmu:60531)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11025660;11481330;19131572;20433842;38285410", "class_list": "", "function": "Efficiently inhibits forskolin-induced production of cAMP. Acts as a potent negative regulator of gonadotropin synthesis and secretion (By similarity). Induces secretion of prolactin (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Efficiently inhibits forskolin-induced production of cAMP. Blocks morphine-induced analgesia., [UniProtKB, UniProtKB]; It is concluded that aging mice exhibits inverse correlation of RFRP-3 neurons and gonadal activity suggesting that function of RFRP-3 is not initiated until 1-week of age and thereafter it could participate in the regulation of gonadal development., [RefSeq, PubMed]; RFRP-3 has a likely direct suppressive action on the excitability of GnRH neurons, indicating a role for RFRPs in the regulation of gonadotropin secretion in mammals through modulation of GnRH neuron activity., [RefSeq, PubMed]; The effect of gonadotropin-inhibitory hormone on steroidogenesis and spermatogenesis by acting through the hypothalamic-pituitary-testis axis in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q920A4", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0160041 neuropeptide activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0032277 negative regulation of gonadotropin secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ESQ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXZ7-1", "uniprot_id": "NR2E3_MOUSE", "mass": 43177.0, "length": 395, "protein_name": "Photoreceptor-specific nuclear receptor", "gene_name": "Nr2e3", "organism": "Mouse", "refseq_name": "photoreceptor-specific nuclear receptor", "refseq_ac": "NP_038736", "gene_names_uniprotkb": "Nr2e3; Pnr; Rnr", "gene_names_refseq": "A930035N01Rik; Nr2e3; PNR; RNR; rd7", "protein_names_uniprotkb": "Photoreceptor-specific nuclear receptor; Nuclear receptor subfamily 2 group E member 3; Retina-specific nuclear receptor", "protein_names_refseq": "photoreceptor-specific nuclear receptor; retina-specific nuclear receptor; retinal degeneration 7", "tax_id": 10090, "disease": "enhanced S-cone syndrome 1 (Disease Ontology:DOID:0061231); enhanced S-cone syndrome (Disease Ontology:DOID:0090059); retinitis pigmentosa 37 (Disease Ontology:DOID:0110399)", "pathway": " (mmu:23958); (R-MMU-383280)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10611353;10805811;15190009;15634773;19186166;21408158;28900001;38790135", "class_list": "", "function": "Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/beta-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-beta catenin-p300 Interactions in Hepatocellular Carcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QXZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVA8-1", "uniprot_id": "NPFF_MOUSE", "mass": 13012.0, "length": 114, "protein_name": "Pro-FMRFamide-related neuropeptide FF", "gene_name": "Npff", "organism": "Mouse", "refseq_name": "pro-FMRFamide-related neuropeptide FF preproprotein", "refseq_ac": "NP_061257", "gene_names_uniprotkb": "Npff", "gene_names_refseq": "Npff", "protein_names_uniprotkb": "Pro-FMRFamide-related neuropeptide FF; FMRFamide-related peptides", "protein_names_refseq": "FMRFamide-related peptides; pro-FMRFamide-related neuropeptide FF preproprotein; pro-FMRFamide-related neuropeptide FF", "tax_id": 10090, "disease": "", "pathway": " (mmu:54615); (R-MMU-389397); (R-MMU-416476)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10220558;10798398;12149260;16515822;18295932;37055592;38965251", "class_list": "", "function": "Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse., [RefSeq, PubMed]; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels., [UniProtKB, PubMed]; Npff reduces the expression of cocaine-induced conditioned place preference and cocaine-induce sensitization in mice., [RefSeq, PubMed]; Plays a role in body energy storage and utilization through adipocyte metabolism, [RefSeq, PubMed]; Renal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes neuropeptides involved in analgesia, cardiovascular regulation, neuroendocrine function and opiate addiction. The encoded protein is a preproprotein that undergoes further processing to generate multiple amidated peptides. [provided by RefSeq, Jul 2015]., [RefSeq]; We postulate that Oct-1, PDX1, Pit-1, MEIS and DREAM are likely transcriptional regulators of NPFF gene expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity;GO:0160041 neuropeptide activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0043679 axon terminus", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0021510 spinal cord development;GO:0045777 positive regulation of blood pressure;GO:0060079 excitatory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WVA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0W3-1", "uniprot_id": "NU160_MOUSE", "mass": 158232.0, "length": 1402, "protein_name": "Nuclear pore complex protein Nup160", "gene_name": "Nup160", "organism": "Mouse", "refseq_name": "nuclear pore complex protein Nup160 isoform 1", "refseq_ac": "NP_067487", "gene_names_uniprotkb": "Nup160; Gtl1-13; Kiaa0197", "gene_names_refseq": "160kDa; 2810011M03Rik; Gtl-13; Gtl1-13; Gtl13; Nup160; mKIAA0197", "protein_names_uniprotkb": "Nuclear pore complex protein Nup160; 160 kDa nucleoporin; GTL-13; Gene trap locus 1-13 protein; Nucleoporin Nup160", "protein_names_refseq": "160 kDa nucleoporin; gene trap locus 1-13 protein; gene trap locus-13; nuclear pore complex protein Nup160 isoform 1; nuclear pore complex protein Nup160; nucleoporin 160kDa; nucleoporin Nup160", "tax_id": 10090, "disease": "nephrotic syndrome type 19 (Disease Ontology:DOID:0080394)", "pathway": " (mmu:59015); (R-MMU-141430); (R-MMU-141444); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9615933); (R-MMU-9648025)", "pathway_count": 26, "publication_count": 18, "publication_id_list": "11564755;11684705;17242355;19131326;21183079;21952136;22872234;25428506;25605945;29704630;30084848;31219806;33300544;34203471;34428180;34533106;34887587;38224683", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Involved in poly(A)+ RNA transport (PubMed:11684705)., [UniProtKB, PubMed, PubMed]; Knockdown of NUP160 impairs mouse podocytes, i.e. inhibiting cell proliferation, inducing apoptosis, autophagy and cell migration of mouse podocytes, and altering the expression and localization of podocyte associated molecules, [RefSeq, PubMed]; Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy., [RefSeq, PubMed]; Podocyte-specific Nup160 knockout mice develop nephrotic syndrome and glomerulosclerosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBI7;Q3TP11;Q3U250;Q6A0A7;Q7TME1;Q9CZD9", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore", "go_biological_process": "GO:0072006 nephron development;GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9Z0W3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3N1-1", "uniprot_id": "NOP14_MOUSE", "mass": 98769.0, "length": 860, "protein_name": "Nucleolar protein 14", "gene_name": "Nop14", "organism": "Mouse", "refseq_name": "nucleolar protein 14", "refseq_ac": "NP_083554", "gene_names_uniprotkb": "Nop14; Nol14", "gene_names_refseq": "2610033H07Rik; Nol14; Nop14", "protein_names_uniprotkb": "Nucleolar protein 14; Nucleolar complex protein 14", "protein_names_refseq": "NOP14 nucleolar protein homolog; nucleolar protein 14; probable nucleolar complex protein 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:75416); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16479539;17242355;19144319;21183079;21750661;25428506;30084848;31219806;34428180;35820727;37828378", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5RL78", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030692 Noc4p-Nop14p complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R3N1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJG1-1", "uniprot_id": "NOL10_MOUSE", "mass": 80077.0, "length": 687, "protein_name": "Nucleolar protein 10", "gene_name": "Nol10", "organism": "Mouse", "refseq_name": "nucleolar protein 10", "refseq_ac": "NP_001008421", "gene_names_uniprotkb": "Nol10; Gm67", "gene_names_refseq": "Gm67; Nol10", "protein_names_uniprotkb": "Nucleolar protein 10", "protein_names_refseq": "nucleolar protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:217431)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25428506;26495903;30084848;30779550;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5RJG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJG9-1", "uniprot_id": "NOA1_MOUSE", "mass": 77379.0, "length": 693, "protein_name": "Nitric oxide-associated protein 1", "gene_name": "Noa1", "organism": "Mouse", "refseq_name": "nitric oxide-associated protein 1 isoform 1", "refseq_ac": "NP_062810", "gene_names_uniprotkb": "Noa1; MNCb-4931", "gene_names_refseq": "2610024G14Rik; AtNOS1; Noa1; mAtNOS1", "protein_names_uniprotkb": "Nitric oxide-associated protein 1", "protein_names_refseq": "nitric oxide-associated protein 1 isoform 1; nitric oxide-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56412)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16380119;18456285;20173027;21118999;23933583;25072814;25428506;30084848;31219806", "class_list": "", "function": "Data show that NOA1 is required for mitochondrial protein synthesis, likely due to its yet unidentified role in mitoribosomal biogenesis; NOA1 is required for such basal mitochondrial functions as adenosine triphosphate (ATP) synthesis and apoptosis, [RefSeq, PubMed]; Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP., [UniProtKB, PubMed, PubMed]; NOA1 binds specifically to oligonucleotides that fold into guanine tetrads (G-quadruplexes)., [RefSeq, PubMed]; Our results uncovered an unexpected, mandatory detour of NOA1 through the nucleolus before uptake into mitochondria. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T996;Q3U044;Q99JU4", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding;GO:0140691 RNA folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0099617 matrix side of mitochondrial inner membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0007005 mitochondrion organization;GO:0061668 mitochondrial ribosome assembly;GO:0180026 mitochondrial small ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JJG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQV3-1", "uniprot_id": "SPB11_MOUSE", "mass": 43482.0, "length": 388, "protein_name": "Serpin B11", "gene_name": "Serpinb11", "organism": "Mouse", "refseq_name": "serpin B11", "refseq_ac": "NP_080143", "gene_names_uniprotkb": "Serpinb11", "gene_names_refseq": "2310046M08Rik; Serpinb11", "protein_names_uniprotkb": "Serpin B11", "protein_names_refseq": "serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 11; serpin B11", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (mmu:66957)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15203215;17562709;21750661;24781146;24785531;25428506", "class_list": "", "function": "Inhibitor of serine proteases. Has moderate inhibitory activity for trypsin-like peptidases, but also some activity with cysteine peptidases, cathepsin L, K, and V, and the serine peptidase, tryptase gamma., [UniProtKB, PubMed]; SERPINB11 is a new noninhibitory intracellular serpin, [RefSeq, PubMed]; SerpinB11 is probably involved in embryo implantation and decidualization., [RefSeq, PubMed]; The spatiotemporal expression and localization implicates a potential role for SerpinB11 in the process of mouse spermatogenesis and apoptosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91Z12", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMS2-1", "uniprot_id": "SPON2_MOUSE", "mass": 35965.0, "length": 330, "protein_name": "Spondin-2", "gene_name": "Spon2", "organism": "Mouse", "refseq_name": "spondin-2 precursor", "refseq_ac": "NP_598664", "gene_names_uniprotkb": "Spon2", "gene_names_refseq": "2310045I24Rik; M-spondin; Mindin; Mspondin; Spon2", "protein_names_uniprotkb": "Spondin-2; Mindin", "protein_names_refseq": "spondin-2 precursor; spondin-2", "tax_id": 10090, "disease": "meningioma (Disease Ontology:DOID:3565)", "pathway": " (mmu:100689); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14691481;16917498;18424748;18818374;21750661;32253812;32614521;36528128", "class_list": "", "function": "Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Binds bacterial lipopolysaccharide. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens., [UniProtKB, PubMed]; Mindin (SPON2) Is Essential for Cutaneous Fibrogenesis in a Mouse Model of Systemic Sclerosis., [RefSeq, PubMed]; Mindin deficiency alleviates renal fibrosis through inhibiting NF-kappaB and TGF-beta/Smad pathways., [RefSeq, PubMed]; Mindin is a pattern-recognition molecule for microbial pathogens., [RefSeq, PubMed]; Mindin participates in integrin-dependent trafficking of eosinophils and can contribute to the severity of allergic airways disease., [RefSeq, PubMed]; Mindin plays an essential role in the host innate immune response to influenza virus infection and suggest that mindin may be used as an immune-enhancing agent in influenza infection., [RefSeq, PubMed]; Mindin serves as a tumour suppressor gene during colon cancer progression through MAPK/ERK signalling pathway in mice., [RefSeq, PubMed]; Mindin-integrin interactions play a key role in regulating Rho GTPase expression in DCs and DC priming of T lymphocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 1, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6SJD8", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0001530 lipopolysaccharide binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0032496 response to lipopolysaccharide;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BMS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6S5L9-1", "uniprot_id": "SHC4_MOUSE", "mass": 68519.0, "length": 626, "protein_name": "SHC-transforming protein 4", "gene_name": "Shc4", "organism": "Mouse", "refseq_name": "SHC-transforming protein 4", "refseq_ac": "NP_950187", "gene_names_uniprotkb": "Shc4; Shcd", "gene_names_refseq": "6230417E10Rik; 9930029B02Rik; Gm685; RaLP; Shc4", "protein_names_uniprotkb": "SHC-transforming protein 4; RaLP; Rai-like protein; SH2 domain protein C4; SHC-transforming protein D; Src homology 2 domain-containing-transforming protein C4; mShcD", "protein_names_refseq": "SH2 domain protein C4; SHC-transforming protein 4; SHC-transforming protein D; mShcD; novel phosphotyrosine interaction domain (PTB/PID) and SH2 domains containing protein; rai-like protein RaLP; src homology 2 domain-containing-transforming protein C4", "tax_id": 10090, "disease": "", "pathway": " (mmu:271849)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17409413;17452444;21117147;21750661;22948967;31121283", "class_list": "", "function": "A new member of the Shc family of docking proteins is characterised, which may mediate a specific aspect of signaling downstream of the MuSK receptor., [RefSeq, PubMed]; Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1., [UniProtKB, PubMed]; Data also showed that the death signalling initiated by the ShcD/ERK interaction was accompanied by p21 phosphorylation. In summary, these data identified ShcD, via its interaction with ERK, as a proapoptotic protein under oxidative stress conditions., [RefSeq, PubMed]; Shc4 is an important modulator in the switch of key pathway(s) involved in determining epiblast stem cell identity., [RefSeq, PubMed]; The unique tissue distribution patterns of Shc proteins likely contribute to their complex tissue-specific signaling functions during embryogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0048863 stem cell differentiation;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6S5L9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7TZE6-1", "uniprot_id": "SKIT1_MOUSE", "mass": 41792.0, "length": 364, "protein_name": "Selection and upkeep of intraepithelial T-cells protein 1", "gene_name": "Skint1", "organism": "Mouse", "refseq_name": "selection and upkeep of intraepithelial T-cells protein 1 precursor", "refseq_ac": "NP_001096132", "gene_names_uniprotkb": "Skint1", "gene_names_refseq": "Skint-1; Skint1", "protein_names_uniprotkb": "Selection and upkeep of intraepithelial T-cells protein 1; Immunoglobulin-like and transmembrane domain-containing protein expressed in skin and thymus protein 1; Skint-1", "protein_names_refseq": "Immunoglobulin-like and transmembrane domain-containing protein expressed in skin and thymus protein 1; selection and upkeep of intraepithelial T-cells protein 1 precursor; selection and upkeep of intraepithelial T-cells protein 1; skint 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:639781)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18408721;21300860;21737317;22872234;25830554;30084848;34428180", "class_list": "", "function": "Identifies a common molecular mechanism for the development of interferon-gamma-secreting versus interleukin-17-secreting gammadelta T cells, [RefSeq, PubMed]; May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus. Plays a central role in mediating key epithelial-immune interactions by being involved in the selection of Vgamma5(+)Vdelta1(+) T-cells, which constitute 90% of epidermal gammadelta T-cells., [UniProtKB, PubMed]; Skint1 is the prototypic member of a rapidly evolving family of at least 11 genes in mouse, with greatest similarity to the butyrophilin genes., [RefSeq, PubMed]; Transgenic Skint-1, across a broad range of transgenic Skint-1, across a broad range of expression levels, precisely and selectively determines the Vgamma5Vdelta1(+) dendritic epidermal T-cell compartment, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7TZE7;A7XUW2;A7XUW8;A7XUX1;A9XK90", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0033089 positive regulation of T cell differentiation in thymus;GO:0001817 regulation of cytokine production;GO:0045059 positive thymic T cell selection;GO:0045582 positive regulation of T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A7TZE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7TZF0-1", "uniprot_id": "SKIT3_MOUSE", "mass": 53068.0, "length": 458, "protein_name": "Selection and upkeep of intraepithelial T-cells protein 3", "gene_name": "Skint3", "organism": "Mouse", "refseq_name": "selection and upkeep of intraepithelial T-cells protein 3 isoform a precursor", "refseq_ac": "NP_001095944", "gene_names_uniprotkb": "Skint3", "gene_names_refseq": "A430090E18Rik; Skint-3; Skint3", "protein_names_uniprotkb": "Selection and upkeep of intraepithelial T-cells protein 3; Skint-3", "protein_names_refseq": "Selection and upkeep of intraepithelial T-cells protein 3; selection and upkeep of intraepithelial T-cells protein 3 isoform a precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:195564)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18408721", "class_list": "", "function": "May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7TZF2;Q8BIN0", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production;GO:0050863 regulation of T cell activation;GO:1903037 regulation of leukocyte cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7TZF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7TZG1-1", "uniprot_id": "SKI10_MOUSE", "mass": 40861.0, "length": 354, "protein_name": "Selection and upkeep of intraepithelial T-cells protein 10", "gene_name": "Skint10", "organism": "Mouse", "refseq_name": "selection and upkeep of intraepithelial T-cells protein 10 precursor", "refseq_ac": "NP_808336", "gene_names_uniprotkb": "Skint10", "gene_names_refseq": "A030001H23Rik; Gm570; Skint10", "protein_names_uniprotkb": "Selection and upkeep of intraepithelial T-cells protein 10; Skint-10", "protein_names_refseq": "selection and upkeep of intraepithelial T-cells protein 10 precursor; selection and upkeep of intraepithelial T-cells protein 10; skint 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:230613)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18408721", "class_list": "", "function": "May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7TZG2;Q8CAZ8", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7TZG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7TZG3-1", "uniprot_id": "SKIT9_MOUSE", "mass": 36119.0, "length": 319, "protein_name": "Selection and upkeep of intraepithelial T-cells protein 9", "gene_name": "Skint9", "organism": "Mouse", "refseq_name": "selection and upkeep of intraepithelial T-cells protein 9 precursor", "refseq_ac": "NP_808532", "gene_names_uniprotkb": "Skint9", "gene_names_refseq": "A030013N09Rik; Skint-9; Skint9", "protein_names_uniprotkb": "Selection and upkeep of intraepithelial T-cells protein 9; Skint-9", "protein_names_refseq": "Selection and upkeep of intraepithelial T-cells protein 9; selection and upkeep of intraepithelial T-cells protein 9 precursor; skint 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:329918)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18408721", "class_list": "", "function": "May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7TZG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7XUX6-1", "uniprot_id": "SKIT2_MOUSE", "mass": 45644.0, "length": 400, "protein_name": "Selection and upkeep of intraepithelial T-cells protein 2", "gene_name": "Skint2", "organism": "Mouse", "refseq_name": "selection and upkeep of intraepithelial T-cells protein 2 isoform a precursor", "refseq_ac": "NP_001272892", "gene_names_uniprotkb": "Skint2", "gene_names_refseq": "A430070M19; B7S3; Skint-2; Skint2", "protein_names_uniprotkb": "Selection and upkeep of intraepithelial T-cells protein 2; Skint-2", "protein_names_refseq": "selection and upkeep of intraepithelial T-cells protein 2 isoform a precursor; selection and upkeep of intraepithelial T-cells protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:329919)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18408721;21750661", "class_list": "", "function": "May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7TZE8;A7TZE9;A7XUY1", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042608 T cell receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production;GO:0050868 negative regulation of T cell activation;GO:0050863 regulation of T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A7XUX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7XUZ6-1", "uniprot_id": "SKIT6_MOUSE", "mass": 141567.0, "length": 1240, "protein_name": "Selection and upkeep of intraepithelial T-cells protein 6", "gene_name": "Skint6", "organism": "Mouse", "refseq_name": "selection and upkeep of intraepithelial T-cells protein 6 precursor", "refseq_ac": "NP_001096669", "gene_names_uniprotkb": "Skint6", "gene_names_refseq": "Skint6", "protein_names_uniprotkb": "Selection and upkeep of intraepithelial T-cells protein 6; Skint-6", "protein_names_refseq": "selection and upkeep of intraepithelial T-cells protein 6 precursor; selection and upkeep of intraepithelial T-cells protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:230622)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18408721;25428506;28490805;30779550;34428180", "class_list": "", "function": "May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus., [UniProtKB]; Skint6 variant in the rec1d1 interval is the most likely causative gene of mouse lupus., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A7XV01", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production;GO:0050863 regulation of T cell activation;GO:1903037 regulation of leukocyte cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A7XUZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHJ9-1", "uniprot_id": "SLU7_MOUSE", "mass": 68080.0, "length": 585, "protein_name": "Pre-mRNA-splicing factor SLU7", "gene_name": "Slu7", "organism": "Mouse", "refseq_name": "pre-mRNA-splicing factor SLU7", "refseq_ac": "NP_683514", "gene_names_uniprotkb": "Slu7; D11Ertd730e", "gene_names_refseq": "D11Ertd730e; D3Bwg0878e; Slu7", "protein_names_uniprotkb": "Pre-mRNA-splicing factor SLU7", "protein_names_refseq": "pre-mRNA-splicing factor SLU7; step II splicing factor SLU7", "tax_id": 10090, "disease": "", "pathway": " (mmu:193116); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "19144319;21183079;21750661;24865429;29870742;34170569", "class_list": "", "function": "Involved in pre-mRNA splicing., [UniProtKB, UniProtKB, UniProtKB]; Knockdown of hepatic Slu7 by adenovirus-Slu7shRNA treatment ameliorated inflammation and attenuated liver injury in mice after ethanol administration., [RefSeq, PubMed]; Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SLU7 knockdown in liver resulted in profound changes in pre-mRNA splicing and gene expression, leading to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern., [RefSeq, PubMed]; Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4alpha Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQQ3;Q5SRU1;Q63ZX3;Q6P923;Q8BL59;Q8BXD5;Q8R5C1;Q91YV6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030628 pre-mRNA 3'-splice site binding;GO:0000386 second spliceosomal transesterification activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0006886 intracellular protein transport;GO:0034605 cellular response to heat;GO:0000380 alternative mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BHJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CG48-1", "uniprot_id": "SMC2_MOUSE", "mass": 134239.0, "length": 1191, "protein_name": "Structural maintenance of chromosomes protein 2", "gene_name": "Smc2", "organism": "Mouse", "refseq_name": "structural maintenance of chromosomes protein 2", "refseq_ac": "NP_001288341", "gene_names_uniprotkb": "Smc2; Cape; Fin16; Smc2l1", "gene_names_refseq": "5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2; Smc2l1; Smc2", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 2; Chromosome-associated protein E; FGF-inducible protein 16; SMC protein 2; SMC-2; XCAP-E homolog", "protein_names_refseq": "FGF-inducible protein 16; SMC protein 2; SMC2 structural maintenance of chromosomes 2-like 1; XCAP-E homolog; chromosome-associated protein E; fibroblast growth factor inducible 16; structural maintenance of chromosomes protein 2", "tax_id": 10090, "disease": "colon adenocarcinoma (Disease Ontology:DOID:234); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:14211); (R-MMU-2299718); (R-MMU-2514853)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "14660695;21750661;22872234;23806337;25428506;30084848;31219806;31599954;34203471;34428180;34887587;36210013;37642322;39627609;8649829", "class_list": "", "function": "Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity)., [UniProtKB]; Maternal SMC2 is essential for embryonic development via participating chromosome condensation in mice., [RefSeq, PubMed]; The protein encoded by this gene is a component of both condensin I and condensin II complexes, and forms a heterodimer with structural maintenance of chromosome 4 (Smc4). This heterodimer is the catalytic subunit for both condensin complexes, and is involved in several processes, including chromosome condensation during mitosis and meiosis, cohesin removal during mitosis and meiosis, and single-strand break (SSB) repair. Reduced expression of this gene results in chromosome segregation defects during mitosis and meiosis, with a more severe defect observed in embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52KE9;Q61076;Q9CS17;Q9CSD8", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:1905820 positive regulation of chromosome separation;GO:0051383 kinetochore organization;GO:0051984 positive regulation of chromosome segregation;GO:0051301 cell division;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8CG48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P9P0-1", "uniprot_id": "SLF2_MOUSE", "mass": 143970.0, "length": 1278, "protein_name": "SMC5-SMC6 complex localization factor protein 2", "gene_name": "Slf2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Slf2; Fam178a", "gene_names_refseq": "", "protein_names_uniprotkb": "SMC5-SMC6 complex localization factor protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "mosaic variegated aneuploidy syndrome (Disease Ontology:DOID:0080688)", "pathway": " (mmu:226151)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions. May play a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SIMC1 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C041;Q8C0J5", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016605 PML body;GO:0000785 chromatin;GO:0035861 site of double-strand break", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0031334 positive regulation of protein-containing complex assembly;GO:2000781 positive regulation of double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P9P0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53783-1", "uniprot_id": "SOX1_MOUSE", "mass": 39053.0, "length": 391, "protein_name": "Transcription factor SOX-1", "gene_name": "Sox1", "organism": "Mouse", "refseq_name": "transcription factor SOX-1", "refseq_ac": "NP_033259", "gene_names_uniprotkb": "Sox1; Sox-1", "gene_names_refseq": "Sox-1; Sox1", "protein_names_uniprotkb": "Transcription factor SOX-1", "protein_names_refseq": "SRY-box containing gene 1; transcription factor SOX-1", "tax_id": 10090, "disease": "X-linked panhypopituitarism (Disease Ontology:DOID:0111779)", "pathway": " (mmu:20664)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15456859;22645316;32848054;34203471;40885482;8625802", "class_list": "", "function": "Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q80XF2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030900 forebrain development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53783-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62315-1", "uniprot_id": "SMD1_MOUSE", "mass": 13282.0, "length": 119, "protein_name": "Small nuclear ribonucleoprotein Sm D1", "gene_name": "Snrpd1", "organism": "Mouse", "refseq_name": "small nuclear ribonucleoprotein Sm D1", "refseq_ac": "NP_033252", "gene_names_uniprotkb": "Snrpd1", "gene_names_refseq": "SMD1; Snrpd1", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein Sm D1; Sm-D autoantigen; Sm-D1; snRNP core protein D1", "protein_names_refseq": "sm-D autoantigen; sm-D1; small nuclear ribonucleoprotein Sm D1; snRNP core protein D1", "tax_id": 10090, "disease": "nephritis (Disease Ontology:DOID:10952); proteinuria (Disease Ontology:DOID:576); connective tissue disease (Disease Ontology:DOID:65); systemic lupus erythematosus (Disease Ontology:DOID:9074); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:20641); (R-MMU-191859); (R-MMU-72163); (R-MMU-72165); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10428801;1388635;15324931;15494537;17277166;21750661;22645316;25605945;33300544;34428180;7534800", "class_list": "", "function": "Data suggest that the anti-Sm D response arises as a consequence of antigenic cross-reactivity by anti-EBNA-1 antibodies, supporting a possible association between EBV infection and SLE, [RefSeq, PubMed]; Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA., [UniProtKB, UniProtKB]; SmD1 83-119 peptide may play a dominant role in the activation of helper and regulatory T cells that influence autoantibody generation and murine lupus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P13641;Q3UYM0", "ec_number_list": "", "go_molecular_function": "GO:1990446 U1 snRNP binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P62315-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70277-1", "uniprot_id": "SIA7B_MOUSE", "mass": 42482.0, "length": 373, "protein_name": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2", "gene_name": "St6galnac2", "organism": "Mouse", "refseq_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 isoform 1", "refseq_ac": "NP_033206", "gene_names_uniprotkb": "St6galnac2; Siat7b; Siat7", "gene_names_refseq": "II; ST6GalNAc; Siat7b; Siat7; St6galnac2", "protein_names_uniprotkb": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; 2.4.3.3; Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase; GalNAc alpha-2,6-sialyltransferase II; SIAT7-B; ST6GalNAc II; ST6GalNAcII; Sialyltransferase 7B", "protein_names_refseq": "Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase; SIAT7-B; ST6GalNAc II; ST6GalNAcII; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 isoform 1; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase II; galNAc alpha-2,6-sialyltransferase II; sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) B; sialyltransferase 7B", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:20446); (R-MMU-4085001); (R-MMU-977068)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "25605945;26495903;28011936;30084848;34428180;8662927", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins (PubMed:8662927). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins. Sialylates alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr epitopes also known as Tn and T antigens., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWG0;Q9DC24", "ec_number_list": "2.4.3.3;2.4.99.-;2.4.3.7", "go_molecular_function": "GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0009101 glycoprotein biosynthetic process;GO:1990743 protein sialylation", "synthesized_glycan_count": 550, "hit_score": 0.7, "record_id": "P70277-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P82348-1", "uniprot_id": "SGCG_MOUSE", "mass": 32082.0, "length": 291, "protein_name": "Gamma-sarcoglycan", "gene_name": "Sgcg", "organism": "Mouse", "refseq_name": "gamma-sarcoglycan", "refseq_ac": "NP_036022", "gene_names_uniprotkb": "Sgcg", "gene_names_refseq": "35kDa; 5430420E18Rik; Sgcg; gamma-SG", "protein_names_uniprotkb": "Gamma-sarcoglycan; 35 kDa dystrophin-associated glycoprotein; 35DAG; Gamma-SG", "protein_names_refseq": "35 kDa dystrophin-associated glycoprotein; 35DAG; gamma-sarcoglycan; sarcoglycan, gamma (35kD dystrophin-associated glycoprotein)", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); autosomal recessive limb-girdle muscular dystrophy type 2C (Disease Ontology:DOID:0110277); dilated cardiomyopathy 1L (Disease Ontology:DOID:0110436); limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); type 2 diabetes mellitus (Disease Ontology:DOID:9352); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:24053); (R-MMU-9913351)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10448073;21540332;35796564;7547961;9864373", "class_list": "", "function": "Comparative genomic analyses of multiple backcross mouse populations suggest SGCG as a novel potential obesity-modifier gene., [RefSeq, PubMed]; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0042383 sarcolemma;GO:0016011 dystroglycan complex;GO:0016012 sarcoglycan complex", "go_biological_process": "GO:0060047 heart contraction;GO:0061024 membrane organization;GO:0048738 cardiac muscle tissue development;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P82348-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97363-1", "uniprot_id": "SPTC2_MOUSE", "mass": 62982.0, "length": 560, "protein_name": "Serine palmitoyltransferase 2", "gene_name": "Sptlc2", "organism": "Mouse", "refseq_name": "serine palmitoyltransferase 2", "refseq_ac": "NP_035609", "gene_names_uniprotkb": "Sptlc2; Lcb2", "gene_names_refseq": "LCB2a; LCB2; Spt2; Sptlc2", "protein_names_uniprotkb": "Serine palmitoyltransferase 2; 2.3.1.50; LCB 2; LCB2a; Long chain base biosynthesis protein 2a; Long chain base biosynthesis protein 2; SPT 2; Serine-palmitoyl-CoA transferase 2", "protein_names_refseq": "LCB 2; SPT 2; long chain base biosynthesis protein 2a; long chain base biosynthesis protein 2; serine palmitoyltransferase 2; serine-palmitoyl-CoA transferase 2", "tax_id": 10090, "disease": "hereditary sensory and autonomic neuropathy type 1C (Disease Ontology:DOID:0070157); hereditary sensory and autonomic neuropathy type 1 (Disease Ontology:DOID:0070162); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (mmu:20773); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;1317856;21994399;27818258;28135057;28528544;28698261;34428180;35513574;37224999;8921873;9363775", "class_list": "glycogene", "function": "Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Crucial for adipogenesis (PubMed:28698261)., [UniProtKB, UniProtKB, PubMed]; Hepatic deletion of serine palmitoyl transferase 2 impairs ceramide/sphingomyelin balance, bile acids homeostasis and leads to liver damage in mice., [RefSeq, PubMed]; This gene encodes a long chain base subunit of serine palmitoyltransferase. The enzyme, serine palmitoyltransferase, consists of two different subunits, and is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. A mutant allele of this gene in mice is used as a model for the human disease 'Susceptibilty to Psoriasis 1'. Mutations in the human gene are associated with hereditary sensory neuropathy type I. [provided by RefSeq, Sep 2015]., [RefSeq]; Upregulation of the serine palmitoyltransferase subunit SPTLC2 by endoplasmic reticulum stress inhibits the hepatic insulin response., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97356", "ec_number_list": "2.3.1.50", "go_molecular_function": "GO:0004758 serine C-palmitoyltransferase activity;GO:0030170 pyridoxal phosphate binding", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0046511 sphinganine biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P97363-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04890-1", "uniprot_id": "SOX12_MOUSE", "mass": 34083.0, "length": 314, "protein_name": "Transcription factor SOX-12", "gene_name": "Sox12", "organism": "Mouse", "refseq_name": "transcription factor SOX-12", "refseq_ac": "NP_035568", "gene_names_uniprotkb": "Sox12; Sox-12", "gene_names_refseq": "2010205A02Rik; Sox12", "protein_names_uniprotkb": "Transcription factor SOX-12", "protein_names_refseq": "SRY-box containing gene 12; transcription factor SOX-12", "tax_id": 10090, "disease": "", "pathway": " (mmu:20667)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18403418;18505825;20596238;25428506;30190287;32152552;8441686;8921394", "class_list": "", "function": "Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells., [RefSeq, PubMed]; Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3' (PubMed:18403418, PubMed:18505825, PubMed:30190287). Acts as a transcriptional activator (PubMed:18403418, PubMed:18505825, PubMed:30190287). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (PubMed:18403418, PubMed:18505825). Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions (PubMed:30190287). Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation (PubMed:30190287). Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (PubMed:20596238)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AS82;P70417;Q6NXL2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0021510 spinal cord development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q04890-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q32MG2-1", "uniprot_id": "CBY2_MOUSE", "mass": 51865.0, "length": 446, "protein_name": "Protein chibby homolog 2", "gene_name": "Cby2", "organism": "Mouse", "refseq_name": "protein chibby homolog 2 isoform 1", "refseq_ac": "NP_001157611", "gene_names_uniprotkb": "Cby2; Nurit; Spert", "gene_names_refseq": "1700086N05Rik; Cby2; Nurit; Spert", "protein_names_uniprotkb": "Protein chibby homolog 2; Protein nurit; Spermatid-associated protein", "protein_names_refseq": "novel leucine zipper testicular protein; protein chibby homolog 2 isoform 1; protein chibby homolog 2; spermatid associated; spermatid-associated protein; testis-specific leucine zipper protein nurit", "tax_id": 10090, "disease": "", "pathway": " (mmu:67926)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12204287;21750661;25428506", "class_list": "", "function": "Immunogold electron microscopy revealed that the protein is restricted, from its first detectable appearance, to a unique spermatid organelle called the 'flower-like structure', [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIV5;Q9D9E6;Q9D9Z0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0031410 cytoplasmic vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q32MG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3ULG3-1", "uniprot_id": "SRARP_MOUSE", "mass": 17055.0, "length": 163, "protein_name": "Steroid receptor-associated and regulated protein", "gene_name": "Srarp", "organism": "Mouse", "refseq_name": "steroid receptor-associated and regulated protein", "refseq_ac": "NP_001028546", "gene_names_uniprotkb": "Srarp", "gene_names_refseq": "Gm694; Srarp", "protein_names_uniprotkb": "Steroid receptor-associated and regulated protein", "protein_names_refseq": "steroid receptor-associated and regulated protein; uncharacterized protein C1orf64 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:277744)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May regulate the transcriptional function of androgen and estrogen receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3ULG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UTD9-1", "uniprot_id": "SIM15_MOUSE", "mass": 8591.0, "length": 74, "protein_name": "Small integral membrane protein 15", "gene_name": "Smim15", "organism": "Mouse", "refseq_name": "small integral membrane protein 15", "refseq_ac": "NP_001041715", "gene_names_uniprotkb": "Smim15", "gene_names_refseq": "2810008M24Rik; Smim15", "protein_names_uniprotkb": "Small integral membrane protein 15", "protein_names_refseq": "UPF0542 protein C5orf43 homolog; small integral membrane protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:75616)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UTD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SX79-1", "uniprot_id": "SHRM1_MOUSE", "mass": 89951.0, "length": 823, "protein_name": "Protein Shroom1", "gene_name": "Shroom1", "organism": "Mouse", "refseq_name": "protein Shroom1 isoform 2", "refseq_ac": "NP_001277718", "gene_names_uniprotkb": "Shroom1", "gene_names_refseq": "Apx; Shrm1; Shroom1", "protein_names_uniprotkb": "Protein Shroom1", "protein_names_refseq": "protein Shroom1 isoform 2; protein Shroom1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71774)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18550613;21183079;21750661;22493320;25428506;30059200;32823670", "class_list": "", "function": "May be involved in the assembly of microtubule arrays during cell elongation., [UniProtKB]; Shroom localises exclusively to pulmonary smooth muscle cells and is attenuated in pulmonary arterial hypertension, [RefSeq, PubMed]; Suppression of SHROOM1 Improves In Vitro and In Vivo Gene Integration by Promoting Homology-Directed Repair. Publication Status: Online-Only, [RefSeq, PubMed]; The structure of Shrm domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm function, is reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B1AQY5;B1AQY6;Q5SX83;Q99JP8", "ec_number_list": "", "go_molecular_function": "GO:0045159 myosin II binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005912 adherens junction;GO:0016324 apical plasma membrane;GO:0030864 cortical actin cytoskeleton;GO:0043296 apical junction complex", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0051017 actin filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5SX79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P3D7-1", "uniprot_id": "SPIC_MOUSE", "mass": 27942.0, "length": 242, "protein_name": "Transcription factor Spi-C", "gene_name": "Spic", "organism": "Mouse", "refseq_name": "transcription factor Spi-C", "refseq_ac": "NP_035591", "gene_names_uniprotkb": "Spic", "gene_names_refseq": "Prf; Spi-C; Spic", "protein_names_uniprotkb": "Transcription factor Spi-C; Prf; Pu.1-related factor", "protein_names_refseq": "pu.1-related factor; transcription factor Spi-C", "tax_id": 10090, "disease": "", "pathway": " (mmu:20728)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10187812;10464163;16338660;19037245;21750661;30059200;30084848;30779550;31219806;34428180;37595034", "class_list": "", "function": "Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression., [UniProtKB, PubMed]; Spic regulates one-carbon metabolism and histone methylation in ground-state pluripotency., [RefSeq, PubMed]; The Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U064;Q3U0G6;Q3U1E9;Q9Z0Y0", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001824 blastocyst development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6P3D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZWQ7-1", "uniprot_id": "SPCS3_MOUSE", "mass": 20313.0, "length": 180, "protein_name": "Signal peptidase complex subunit 3", "gene_name": "Spcs3", "organism": "Mouse", "refseq_name": "signal peptidase complex subunit 3", "refseq_ac": "NP_083977", "gene_names_uniprotkb": "Spcs3", "gene_names_refseq": "1810011E08Rik; SPC22/23; Spcs3", "protein_names_uniprotkb": "Signal peptidase complex subunit 3; Microsomal signal peptidase 22/23 kDa subunit; SPC22/23; SPase 22/23 kDa subunit", "protein_names_refseq": "SPase 22/23 kDa subunit; microsomal signal peptidase 22/23 kDa subunit; signal peptidase complex subunit 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:76687); (R-MMU-422085); (R-MMU-9768727)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "40997131", "class_list": "", "function": "Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1D0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005787 signal peptidase complex", "go_biological_process": "GO:0019082 viral protein processing;GO:0006508 proteolysis;GO:0045047 protein targeting to ER;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6ZWQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q78RX3-1", "uniprot_id": "SIM12_MOUSE", "mass": 10796.0, "length": 92, "protein_name": "Small integral membrane protein 12", "gene_name": "Smim12", "organism": "Mouse", "refseq_name": "small integral membrane protein 12", "refseq_ac": "NP_084528", "gene_names_uniprotkb": "Smim12", "gene_names_refseq": "Smim12", "protein_names_uniprotkb": "Small integral membrane protein 12", "protein_names_refseq": "UPF0767 protein C1orf212 homolog; small integral membrane protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:80284)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q78RX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M6Y2-1", "uniprot_id": "SOX11_MOUSE", "mass": 42629.0, "length": 395, "protein_name": "Transcription factor SOX-11", "gene_name": "Sox11", "organism": "Mouse", "refseq_name": "transcription factor SOX-11", "refseq_ac": "NP_033260", "gene_names_uniprotkb": "Sox11; Sox-11", "gene_names_refseq": "1110038H03Rik; 6230403H02Rik; Sox11; end1", "protein_names_uniprotkb": "Transcription factor SOX-11", "protein_names_refseq": "SRY-box containing gene 11; transcription factor SOX-11", "tax_id": 10090, "disease": "Coffin-Siris syndrome 9 (Disease Ontology:DOID:0070057); Coffin-Siris syndrome (Disease Ontology:DOID:1925); Weissenbacher-Zweymuller syndrome (Disease Ontology:DOID:4258)", "pathway": " (mmu:20666)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12923295;15345747;15456859;18403418;18505825;20596238;29973868;40885482;8441686;9337129", "class_list": "", "function": "Transcription factor that acts as a transcriptional activator (PubMed:18403418, PubMed:18505825). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (PubMed:18403418, PubMed:18505825). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (PubMed:20596238). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (PubMed:20596238)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35178;O89036;Q04889;Q80XF0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:2000648 positive regulation of stem cell proliferation;GO:0021782 glial cell development;GO:0061386 closure of optic fissure;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7M6Y2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG54-1", "uniprot_id": "SPTC3_MOUSE", "mass": 63486.0, "length": 563, "protein_name": "Serine palmitoyltransferase 3", "gene_name": "Sptlc3", "organism": "Mouse", "refseq_name": "serine palmitoyltransferase 3", "refseq_ac": "NP_780676", "gene_names_uniprotkb": "Sptlc3; Sptlc2l", "gene_names_refseq": "C130053K05Rik; Sptlc3", "protein_names_uniprotkb": "Serine palmitoyltransferase 3; 2.3.1.50; LCB 3; LCB2b; Long chain base biosynthesis protein 2b; Long chain base biosynthesis protein 3; SPT 3; Serine-palmityl-CoA transferase 3", "protein_names_refseq": "LCB 3; LCB2b; SPT 3; long chain base biosynthesis protein 2b; long chain base biosynthesis protein 3; serine palmitoyltransferase 3; serine-palmitoyl-CoA transferase 3; serine-palmityl-CoA transferase 3", "tax_id": 10090, "disease": "hereditary sensory and autonomic neuropathy type 1 (Disease Ontology:DOID:0070162)", "pathway": " (mmu:228677); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "25607821;27818258;34428180;38660786", "class_list": "glycogene", "function": "Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference., [UniProtKB, UniProtKB]; Hepatic expression of Sptlc3 mRNA may be closely associated with NASH-associated hepatocarcinogenesis., [RefSeq, PubMed]; SPTLC3 Is Essential for Complex I Activity and Contributes to Ischemic Cardiomyopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 25, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q505L2", "ec_number_list": "2.3.1.50", "go_molecular_function": "GO:0004758 serine C-palmitoyltransferase activity;GO:0030170 pyridoxal phosphate binding", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0046512 sphingosine biosynthetic process;GO:0046520 sphingoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BG54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZT2-1", "uniprot_id": "SH3R2_MOUSE", "mass": 80066.0, "length": 735, "protein_name": "E3 ubiquitin-protein ligase SH3RF2", "gene_name": "Sh3rf2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase SH3RF2 isoform 1", "refseq_ac": "NP_001139771", "gene_names_uniprotkb": "Sh3rf2; Posh3; Ppp1r39; Rnf158", "gene_names_refseq": "2310046K19; 9130023G24Rik; Ppp1r39; RNF158; Sh3rf2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SH3RF2; 2.3.2.27; Protein phosphatase 1 regulatory subunit 39; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; SH3 domain-containing RING finger protein 2", "protein_names_refseq": "E3 ubiquitin-protein ligase SH3RF2 isoform 1; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; SH3 domain-containing RING finger protein 2; protein phosphatase 1 regulatory subunit 39; putative E3 ubiquitin-protein ligase SH3RF2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:269016)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;30540932;33894019", "class_list": "", "function": "Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation. Facilitates TNF-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity (By similarity)., [UniProtKB, UniProtKB]; Hepatocyte SH3RF2 Deficiency Is a Key Aggravator for NAFLD., [RefSeq, PubMed]; Sh3rf2 haploinsufficiency is a highly penetrant risk factor for Autism spectrum disorders., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B2RQJ2;Q80VJ1;Q8C122;Q8C1E3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0008157 protein phosphatase 1 binding;GO:0004864 protein phosphatase inhibitor activity;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0031397 negative regulation of protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BZT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C503-1", "uniprot_id": "SIT1_MOUSE", "mass": 19578.0, "length": 180, "protein_name": "Signaling threshold-regulating transmembrane adapter 1", "gene_name": "Sit1", "organism": "Mouse", "refseq_name": "signaling threshold-regulating transmembrane adapter 1", "refseq_ac": "NP_062309", "gene_names_uniprotkb": "Sit1; Sit", "gene_names_refseq": "Sit1; Sit", "protein_names_uniprotkb": "Signaling threshold-regulating transmembrane adapter 1; SHP2-interacting transmembrane adapter protein; Suppression-inducing transmembrane adapter 1", "protein_names_refseq": "SHP2 interacting transmembrane adaptor protein; SHP2-interacting transmembrane adapter protein; signaling threshold-regulating transmembrane adapter 1; suppression-inducing transmembrane adapter 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:54390)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10209036;16107703;18209059;18941181;21183079;21957439;23307938;26495903;28011936", "class_list": "", "function": "Negatively regulates T-cell antigen receptor (TCR)-mediated signaling. Involved in positive selection of T-cells., [UniProtKB, PubMed]; SIT and LAX are important negative regulators of immune responses that functionally cooperate., [RefSeq, PubMed]; SIT and T cell receptor-interacting molecule (TRIM) regulate cell fate of developing thymocytes and are essential regulators of central tolerance., [RefSeq, PubMed]; SIT as an important modulator of TCR-mediated signaling that regulates T-cell activation, homeostasis and tolerance, [RefSeq, PubMed]; SIT is a critical negative regulator of T-cell receptor-mediated signaling, [RefSeq, PubMed]; SIT negatively regulates T cell homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUU5", "ec_number_list": "", "go_molecular_function": "GO:0019900 kinase binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0002250 adaptive immune response;GO:0043029 T cell homeostasis;GO:0050863 regulation of T cell activation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8C503-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K190-1", "uniprot_id": "SAYS1_MOUSE", "mass": 20704.0, "length": 188, "protein_name": "SAYSvFN domain-containing protein 1", "gene_name": "Saysd1", "organism": "Mouse", "refseq_name": "SAYSvFN domain-containing protein 1", "refseq_ac": "NP_080485", "gene_names_uniprotkb": "Saysd1", "gene_names_refseq": "1810063B07Rik; 4930488P03Rik; Saysd1", "protein_names_uniprotkb": "SAYSvFN domain-containing protein 1", "protein_names_refseq": "SAYSvFN domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67509)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;31599954;34428180;37419030", "class_list": "", "function": "The UFMylated ribosome-recognition protein SAYSD1 is predominantly expressed in spermatids but is dispensable for fertility in mice., [RefSeq, PubMed]; Ufmylation 'reader' component of a translocation-associated quality control pathway, a mechanism that takes place when a ribosome has stalled during translation, and which is required to degrade clogged substrates (By similarity). Specifically recognizes and binds ufmylated ribosomes when a ribosome has stalled, promoting the transport of stalled nascent chain via the TRAPP complex to lysosomes for degradation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0141185 UFM1-modified protein reader activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K190-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1K6-1", "uniprot_id": "SPB10_MOUSE", "mass": 45115.0, "length": 397, "protein_name": "Serpin B10", "gene_name": "Serpinb10", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Serpinb10", "gene_names_refseq": "", "protein_names_uniprotkb": "Serpin B10", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-6798695)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30059200", "class_list": "", "function": "Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K1K6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K450-1", "uniprot_id": "SPG16_MOUSE", "mass": 71473.0, "length": 639, "protein_name": "Sperm-associated antigen 16 protein", "gene_name": "Spag16", "organism": "Mouse", "refseq_name": "sperm-associated antigen 16 protein isoform 3", "refseq_ac": "NP_001258462", "gene_names_uniprotkb": "Spag16; Pf20", "gene_names_refseq": "4921511D23Rik; 4930524F24Rik; 4930585K05Rik; Pf20; Spag16; Wdr29", "protein_names_uniprotkb": "Sperm-associated antigen 16 protein; Pf20 protein homolog", "protein_names_refseq": "pf20 protein homolog; sperm-associated WD repeat protein; sperm-associated antigen 16 protein isoform 3; sperm-associated antigen 16 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66722)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12391165;16382026;18367677;19305393;21655194;39853433", "class_list": "", "function": "Data describe the cloning of human and mouse Pf20 proteins that interact with Spag6 protein., [RefSeq, PubMed]; In sperm, SPAG16L is found in the central apparatus of the axoneme. We conclude that SPAG16L is essential for sperm flagellar function., [RefSeq, PubMed]; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia., [UniProtKB, PubMed]; The distinct nuclear localization of SPAG16S and its ability to modulate Spag16L mRNA expression suggest that SPAG16S plays an important role in the gene expression machinery of male germ cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBE7;Q8C450;Q9CPU8;Q9D522", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:1990716 axonemal central apparatus;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0036126 sperm flagellum", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0097231 cell motility in response to calcium ion;GO:0060271 cilium assembly;GO:0035082 axoneme assembly;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K450-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4T1-1", "uniprot_id": "SIA8F_MOUSE", "mass": 45428.0, "length": 398, "protein_name": "Alpha-2,8-sialyltransferase 8F", "gene_name": "St8sia6", "organism": "Mouse", "refseq_name": "alpha-2,8-sialyltransferase 8F", "refseq_ac": "NP_665837", "gene_names_uniprotkb": "St8sia6; Siat8f", "gene_names_refseq": "1700007J08Rik; ST8SiaVI; Siat8f; St8sia6", "protein_names_uniprotkb": "Alpha-2,8-sialyltransferase 8F; 2.4.99.-; SIAT8-F; ST8SiaVI; Sialyltransferase 8F; Sialyltransferase St8Sia VI", "protein_names_refseq": "SIAT8-F; ST8Sia VI; alpha-2,8-sialyltransferase 8F; alpha2,8-sialyltransferase VI; sialyltransferase 8 (alpha-2, 8-sialyltransferase) F; sialyltransferase 8F; sialyltransferase St8Sia VI; sialytransferase St8Sia VI", "tax_id": 10090, "disease": "", "pathway": " (mmu:241230); (R-MMU-4085001); (R-MMU-975577)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11980897;25428506;30084848;30779550;34428180;35379746", "class_list": "glycogene;glycosyltransferase", "function": "Alpha-2,8-sialyltransferase that prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups., [UniProtKB, PubMed]; Cutting Edge: Enhanced Antitumor Immunity in ST8Sia6 Knockout Mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.3.-;2.4.99.-;2.4.3.8", "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0008373 sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0006493 protein O-linked glycosylation;GO:0009247 glycolipid biosynthetic process;GO:0009311 oligosaccharide metabolic process;GO:0009100 glycoprotein metabolic process", "synthesized_glycan_count": 21, "hit_score": 1.0, "record_id": "Q8K4T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2K7-1", "uniprot_id": "SNPC5_MOUSE", "mass": 11856.0, "length": 102, "protein_name": "snRNA-activating protein complex subunit 5", "gene_name": "Snapc5", "organism": "Mouse", "refseq_name": "snRNA-activating protein complex subunit 5", "refseq_ac": "NP_899139", "gene_names_uniprotkb": "Snapc5", "gene_names_refseq": "2010103A03Rik; Snapc5", "protein_names_uniprotkb": "snRNA-activating protein complex subunit 5; SNAPc 19 kDa subunit; SNAPc subunit 5; Small nuclear RNA-activating complex polypeptide 5; snRNA-activating protein complex 19 kDa subunit", "protein_names_refseq": "SNAPc 19 kDa subunit; SNAPc subunit 5; small nuclear RNA activating complex, polypeptide 5, 19kDa; snRNA-activating protein complex 19 kDa subunit; snRNA-activating protein complex subunit 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:330959); (R-MMU-6807505); (R-MMU-76071)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPK5", "ec_number_list": "", "go_molecular_function": "GO:0016251 RNA polymerase II general transcription initiation factor activity;GO:0000995 RNA polymerase III general transcription initiation factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016604 nuclear body;GO:0019185 snRNA-activating protein complex", "go_biological_process": "GO:0006384 transcription initiation at RNA polymerase III promoter;GO:0042795 snRNA transcription by RNA polymerase II;GO:0042796 snRNA transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8R2K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3V5-4", "uniprot_id": "SHLB2_MOUSE", "mass": 44503.0, "length": 400, "protein_name": "Endophilin-B2", "gene_name": "Sh3glb2", "organism": "Mouse", "refseq_name": "endophilin-B2 isoform 1", "refseq_ac": "NP_001276638", "gene_names_uniprotkb": "Sh3glb2; Kiaa1848", "gene_names_refseq": "SPAS-1; Sh3glb2", "protein_names_uniprotkb": "Endophilin-B2; SH3 domain-containing GRB2-like protein B2", "protein_names_refseq": "SH3 domain-containing GRB2-like protein B2; SH3-containing protein SH3GLB2; endophilin-B2 isoform 1; endophilin-B2; stimulator of prostatic adenocarcinoma-specific T-cells-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:227700); (R-MMU-264870); (R-MMU-6794361); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "18303116;25428506;28455444;40684658;40885482", "class_list": "", "function": "Data (including data from studies in knockout mice) suggest that Sh3glb2 regulates trafficking of endocytic vesicles and autophagosomes to late endosomes or lysosomes; despite having an intracellular localization and tissue distribution similar to endophilin B1, endophilin B2 is dispensable for mitochondrial apoptosis., [RefSeq, PubMed]; The immunodominant SPAS-1 epitope SNC9-H(8) arose from a point mutation in one allele of the gene in transgenic adenocarcinoma of mouse prostate tumor cells, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIQ1;Q3U2J4;Q3U824;Q8K140;Q91ZI7", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0006897 endocytosis;GO:0061024 membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R3V5-4", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHQ2-1", "uniprot_id": "SOCS7_MOUSE", "mass": 62784.0, "length": 579, "protein_name": "Suppressor of cytokine signaling 7", "gene_name": "Socs7", "organism": "Mouse", "refseq_name": "suppressor of cytokine signaling 7", "refseq_ac": "NP_619598", "gene_names_uniprotkb": "Socs7; Cish7; Nap4", "gene_names_refseq": "2310063P06Rik; Nap4; Socs7", "protein_names_uniprotkb": "Suppressor of cytokine signaling 7; SOCS-7", "protein_names_refseq": "Nck, Ash and phospholipase C binding protein; SH2 domain containing SOCS box protein SOCS7; SOCS-7; suppressor of cytokine signaling 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:192157)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12052866;15242778;15494444;16127460;19427817;21750661;21913724;24210661;32978373;35201663;35706000", "class_list": "", "function": "Data implicate SOCS7 in the modulation of allergic inflammation and demonstrate that SOCS7 is involved in the regulation of TSLP signaling in mast cells., [RefSeq, PubMed]; Data suggest that SOCS7 is a potent regulator of glucose homeostasis and insulin signaling, [RefSeq, PubMed]; MiR-221 promotes keratinocyte proliferation and migration by targeting SOCS7 and is regulated by YB-1., [RefSeq, PubMed]; PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure. Publication Status: Online-Only, [RefSeq, PubMed]; Prominent expression of Socs7 in the brain suggests an important functional role of SOCS7 in this organ, [RefSeq, PubMed]; Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1 (PubMed:16127460, PubMed:24210661). Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination (PubMed:24210661). The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development (PubMed:24210661). Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation (PubMed:16127460). Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Transforming growth factor-beta1 negatively regulates SOCS7 via EGR1 during wound healing. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1AQY1;Q3UH08", "ec_number_list": "", "go_molecular_function": "GO:0035591 signaling adaptor activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0140031 phosphorylation-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031466 Cul5-RING ubiquitin ligase complex", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0035556 intracellular signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VHQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920D7-1", "uniprot_id": "SG3A1_MOUSE", "mass": 10591.0, "length": 104, "protein_name": "Secretoglobin family 3A member 1", "gene_name": "Scgb3a1", "organism": "Mouse", "refseq_name": "secretoglobin family 3A member 1 isoform a precursor", "refseq_ac": "NP_473378", "gene_names_uniprotkb": "Scgb3a1; Hin1; Pnsp2; Ugrp2", "gene_names_refseq": "HIN-1; LuLeu2; Pnsp2; Scgb3a1; UGRP2; Utgrp2", "protein_names_uniprotkb": "Secretoglobin family 3A member 1; Cytokine HIN-1; High in normal 1; PnSP-2; Pneumo secretory protein 2; Uteroglobin-related protein 2", "protein_names_refseq": "cytokine HIN-1; high in normal 1; pneumo secretory protein 2; secretoglobin family 3A member 1 isoform a precursor; uteroglobin related protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68662)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11481438;11682631;12175512;12406855;12438750;15811345;30768367", "class_list": "", "function": "EGF-induced increase of Ugrp2 occurred at the transcriptional level that required the EGF receptor and the activation of the ERK-MAPK and phosphoinositide-3 kinase pathways, [RefSeq, PubMed]; Expression of Three Secretoglobin Proteins, SCGB1A1, SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia, [RefSeq, PubMed]; Genomic structure and expression patterns of Ugrp2 and its alternative spliced form were characterized, [RefSeq, PubMed]; Highest HIN-1 and UGRP-1 expression is detected in the lung, while lower level HIN-1 expression is also detected in the stomach, heart, small intestine, uterine and mammary glands, [RefSeq, PubMed]; Secreted cytokine-like protein. Inhibits cell growth in vitro., [UniProtKB, UniProtKB]; This gene encodes a small secreted protein that may function in the inhibition of cell growth. Expression of the related gene in humans is downregulated via DNA methylation in breast cancers and other tumor types. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1901741 positive regulation of myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q920D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CSV6-1", "uniprot_id": "SFT2C_MOUSE", "mass": 21949.0, "length": 212, "protein_name": "Vesicle transport protein SFT2C", "gene_name": "Sft2d3", "organism": "Mouse", "refseq_name": "vesicle transport protein SFT2C", "refseq_ac": "NP_080282", "gene_names_uniprotkb": "Sft2d3", "gene_names_refseq": "2610206C24Rik; Sft2d3", "protein_names_uniprotkb": "Vesicle transport protein SFT2C; SFT2 domain-containing protein 3", "protein_names_refseq": "SFT2 domain-containing protein 3; vesicle transport protein SFT2C", "tax_id": 10090, "disease": "", "pathway": " (mmu:67158)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "39927985", "class_list": "", "function": "May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QJT3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CSV6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D263-1", "uniprot_id": "SPIT4_MOUSE", "mass": 18327.0, "length": 159, "protein_name": "Kunitz-type protease inhibitor 4", "gene_name": "Spint4", "organism": "Mouse", "refseq_name": "kunitz-type protease inhibitor 4 precursor", "refseq_ac": "NP_084334", "gene_names_uniprotkb": "Spint4", "gene_names_refseq": "9230105I15Rik; Spint4", "protein_names_uniprotkb": "Kunitz-type protease inhibitor 4; Epididymal trypsin inhibitor Spint4", "protein_names_refseq": "epididymal trypsin inhibitor Spint4; kunitz-type protease inhibitor 4 precursor; kunitz-type protease inhibitor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:78239)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12920233;34105348", "class_list": "", "function": "Spint4 (serine protease inhibitor, Kunitz type 4), and Rnase9 and Rnase10 (ribonuclease, Rnase A family 9 and 10), while for the ESTs AV381130 and AV381126 no putative functions could be predicted, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D263-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JK88-1", "uniprot_id": "SPI2_MOUSE", "mass": 45776.0, "length": 405, "protein_name": "Serpin I2", "gene_name": "Serpini2", "organism": "Mouse", "refseq_name": "serpin I2 precursor", "refseq_ac": "NP_080736", "gene_names_uniprotkb": "Serpini2; Spi14", "gene_names_refseq": "Serpini2; Spi14", "protein_names_uniprotkb": "Serpin I2; Serine protease inhibitor 14", "protein_names_refseq": "pancreas-specific serpin; serine protease inhibitor 14; serpin I2 precursor; serpin I2", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (mmu:67931)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16184191;25428506", "class_list": "", "function": "The rescue of growth retardation, immunodeficiency, and mortality by either Serpini2 bacterial artificial chromosome transgenic expression or by pancreatic enzyme supplementation demonstrates these phenotypes as secondary to malnutrition., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8Z3;Q9D955", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JK88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLI7-1", "uniprot_id": "SPAG6_MOUSE", "mass": 55269.0, "length": 507, "protein_name": "Sperm-associated antigen 6", "gene_name": "Spag6", "organism": "Mouse", "refseq_name": "sperm-associated antigen 6 isoform 1", "refseq_ac": "NP_056588", "gene_names_uniprotkb": "Spag6; Pf16", "gene_names_refseq": "PF16; Spag6l1; Spag6l; Spag6", "protein_names_uniprotkb": "Sperm-associated antigen 6; Axoneme central apparatus protein; Protein PF16 homolog", "protein_names_refseq": "axoneme central apparatus protein; axoneme protein; protein PF16 homolog; sperm-associated antigen 6 isoform 1; sperm-associated antigen 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:50525)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10684790;12167721;12391165;15827353;25428506;30535028", "class_list": "", "function": "Data describe the cloning of human and mouse Pf20 proteins that interact with Spag6 protein., [RefSeq, PubMed]; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility., [UniProtKB, PubMed, PubMed]; Spag6 is essential for sperm flagellar motility and that it is important for the maintenance of the structural integrity of mature sperm. The occurrence of hydrocephalus in the mutant mice also implicates Spag6 in the motility of ependymal cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K461", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005576 extracellular region;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0046847 filopodium assembly;GO:1990138 neuron projection extension;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JLI7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXV9-1", "uniprot_id": "SPY1_MOUSE", "mass": 34004.0, "length": 313, "protein_name": "Protein sprouty homolog 1", "gene_name": "Spry1", "organism": "Mouse", "refseq_name": "protein sprouty homolog 1", "refseq_ac": "NP_001292369", "gene_names_uniprotkb": "Spry1", "gene_names_refseq": "Spry1; sprouty1; spry-1", "protein_names_uniprotkb": "Protein sprouty homolog 1; Spry-1", "protein_names_refseq": "inhibitor of receptor tyrosine kinases; protein sprouty homolog 1; sprouty homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:24063); (R-MMU-182971)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10498682;16877379;17974561;25576668;29501879;34203471;39174793", "class_list": "", "function": "Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (PubMed:25576668)., [UniProtKB, PubMed, PubMed]; Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0001759 organ induction;GO:0046580 negative regulation of Ras protein signal transduction;GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QXV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZS5-1", "uniprot_id": "SGK2_MOUSE", "mass": 41359.0, "length": 367, "protein_name": "Serine/threonine-protein kinase Sgk2", "gene_name": "Sgk2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Sgk2 isoform b", "refseq_ac": "NP_001278081", "gene_names_uniprotkb": "Sgk2", "gene_names_refseq": "Sgk2; Sgkl", "protein_names_uniprotkb": "Serine/threonine-protein kinase Sgk2; 2.7.11.1; Serum/glucocorticoid-regulated kinase 2", "protein_names_refseq": "serine/threonine-protein kinase Sgk2 isoform b; serine/threonine-protein kinase Sgk2", "tax_id": 10090, "disease": "", "pathway": " (mmu:27219); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10548550;15774535;15774536;15871460;21865597;28911860;30084848;34428180", "class_list": "", "function": "Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase., [UniProtKB, PubMed, PubMed, PubMed]; The nucleotide substitution in the Sgkl gene is the causative mutation for defective hair growth in the ypc mutant mouse and the signaling pathway involving SGKL plays an essential role in mammalian hair development, [RefSeq, PubMed]; VRK1 self-represses its activity to phosphorylate PXR through cyclin-dependent kinase 2 (CDK2) in high glucose conditions, resulting in the repression of the PCK1 gene. This PXR phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2-PXR-PP2Calpha-SGK2 pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZC31;Q8R0P6", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.3.2.26;2.3.2.36;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0015459 potassium channel regulator activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QZS5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU03-1", "uniprot_id": "SPIT2_MOUSE", "mass": 27914.0, "length": 252, "protein_name": "Kunitz-type protease inhibitor 2", "gene_name": "Spint2", "organism": "Mouse", "refseq_name": "kunitz-type protease inhibitor 2 isoform b precursor", "refseq_ac": "NP_001076017", "gene_names_uniprotkb": "Spint2; Hai2", "gene_names_refseq": "HAI-2; Spint2", "protein_names_uniprotkb": "Kunitz-type protease inhibitor 2; HAI-2; Hepatocyte growth factor activator inhibitor type 2", "protein_names_refseq": "hepatocyte growth factor activator inhibitor type 2; kunitz-type protease inhibitor 2 isoform b precursor; kunitz-type protease inhibitor 2", "tax_id": 10090, "disease": "congenital secretory sodium diarrhea 3 (Disease Ontology:DOID:0060781); biliary atresia (Disease Ontology:DOID:13608)", "pathway": " (mmu:20733); (R-MMU-6806942); (R-MMU-8852405)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10049781;25605945;30623107;31628112", "class_list": "", "function": "Hai-2 is an essential protease inhibitor for epithelial integrity, Epcam homeostasis and mucosal organization of the intestinal tract. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibitor of HGFAC (By similarity). Also inhibits plasmin, and plasma and tissue kallikrein (By similarity). Inhibits serine protease activity of TMPRSS13 (By similarity). Inhibits serine protease activity of ST14/matriptase in vitro (By similarity)., [UniProtKB, UniProtKB]; Matriptase is a causative agent in the development of congenital tufting enteropathy (CTE) and may provide a new target for the treatment of CTE in individuals carrying SPINT2 mutation Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5D0F2;Q9WU04;Q9WU05", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0060672 epithelial cell morphogenesis involved in placental branching;GO:0001843 neural tube closure;GO:0022408 negative regulation of cell-cell adhesion;GO:0003382 epithelial cell morphogenesis;GO:2000146 negative regulation of cell motility", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WU03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64692-1", "uniprot_id": "SIA8D_MOUSE", "mass": 41256.0, "length": 359, "protein_name": "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase", "gene_name": "St8sia4", "organism": "Mouse", "refseq_name": "CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase isoform 2 precursor", "refseq_ac": "NP_001153217", "gene_names_uniprotkb": "St8sia4; Pst; Siat8d", "gene_names_refseq": "PST-1; PST; SIAT8-D; ST8SiaIV; Siat8d; St8sia4", "protein_names_uniprotkb": "CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; 2.4.3.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; SIAT8-D; ST8SiaIV; Sialyltransferase 8D; Sialyltransferase St8Sia IV", "protein_names_refseq": "CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase isoform 2 precursor; CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; alpha-2,8-sialyltransferase 8D; polysialyltransferase-1; sialyltransferase 8 (alpha-2, 8-sialyltransferase) D; sialyltransferase 8D; sialyltransferase St8Sia IV; sialytransferase St8Sia IV", "tax_id": 10090, "disease": "", "pathway": " (mmu:20452); (R-MMU-4085001); (R-MMU-419037)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;32152506;8690732", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages (PubMed:8690732). Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides, including NCAM1 N-glycans, FETUB N-glycans and AHSG (By similarity). It is noteworthy that alpha-2,3-linked sialic acid is apparently a better acceptor than alpha-2,6-linked sialic acid (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.3.-;2.4.99.-;2.4.3.8", "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0008373 sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0009311 oligosaccharide metabolic process;GO:0006491 N-glycan processing;GO:0097503 sialylation;GO:0001574 ganglioside biosynthetic process", "synthesized_glycan_count": 21, "hit_score": 1.0, "record_id": "Q64692-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TIX9-1", "uniprot_id": "UBP39_MOUSE", "mass": 65146.0, "length": 564, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 39", "gene_name": "Usp39", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 39 isoform 1", "refseq_ac": "NP_613058", "gene_names_uniprotkb": "Usp39", "gene_names_refseq": "CGI-21; D6Wsu157e; SAD1; Usp39", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 39; 3.4.19.12; U4/U6.U5 tri-snRNP-associated 65 kDa protein", "protein_names_refseq": "SnRNP assembly defective 1 homolog; U4/U6.U5 tri-snRNP-associated 65 kDa protein; U4/U6.U5 tri-snRNP-associated protein 2; inactive ubiquitin-specific peptidase 39; ubiquitin carboxyl-terminal hydrolase 39 isoform 1; ubiquitin carboxyl-terminal hydrolase 39; ubiquitin specific protease 39", "tax_id": 10090, "disease": "", "pathway": " (mmu:28035); (R-MMU-72163)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "21750661;22872234;25428506;26495903;29187734;30059200;30084848;31219806;34428180;35139388;35440748;36651806;37923718", "class_list": "", "function": "Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:35139388, PubMed:35440748, PubMed:36651806). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (By similarity). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2. Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair. Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (By similarity). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TI55;Q8BLI5;Q8BZZ5;Q9CQR1", "ec_number_list": "3.6.4.13;3.1.13.-;2.7.7.48;2.7.7.6;3.4.19.12;2.7.11.1;5.2.1.8", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0051301 cell division;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3TIX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62320-1", "uniprot_id": "SMD3_MOUSE", "mass": 13916.0, "length": 126, "protein_name": "Small nuclear ribonucleoprotein Sm D3", "gene_name": "Snrpd3", "organism": "Mouse", "refseq_name": "small nuclear ribonucleoprotein Sm D3", "refseq_ac": "NP_080371", "gene_names_uniprotkb": "Snrpd3; SNRPD3", "gene_names_refseq": "1700043E15Rik; 2310009E13Rik; SMD3; Snrpd3", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein Sm D3; Sm-D3; snRNP core protein D3", "protein_names_refseq": "sm-D3; small nuclear ribonucleoprotein Sm D3; snRNP core protein D3", "tax_id": 10090, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:67332); (R-MMU-111367); (R-MMU-191859); (R-MMU-72163); (R-MMU-72165); (R-MMU-73856); (R-MMU-77588); (R-MMU-9770562)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;19470752;21750661;34428180;37507081;40997131", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (PubMed:19470752)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P43331;Q3TV81", "ec_number_list": "", "go_molecular_function": "GO:1990446 U1 snRNP binding;GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0070034 telomerase RNA binding;GO:0071208 histone pre-mRNA DCP binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006479 protein methylation;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P62320-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06985-1", "uniprot_id": "SIA1B_MOUSE", "mass": 31122.0, "length": 282, "protein_name": "E3 ubiquitin-protein ligase SIAH1B", "gene_name": "Siah1b", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase SIAH1B", "refseq_ac": "NP_001295314", "gene_names_uniprotkb": "Siah1b", "gene_names_refseq": "Siah1b; Sinh1b; siah-1b", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SIAH1B; 2.3.2.27; RING-type E3 ubiquitin transferase SIAH1B; Seven in absentia homolog 1b; Siah-1b; Siah1b", "protein_names_refseq": "E3 ubiquitin-protein ligase SIAH1B; RING-type E3 ubiquitin transferase SIAH1B; drosophila seven-in-absentia gene product homolog; seven in absentia 1B; seven in absentia homolog 1b", "tax_id": 10090, "disease": "", "pathway": " (mmu:20438)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12417719;12842817;14985507;16230351;21109632;21750661;8404535;8632996", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Findings define a Siah-Pard3A signaling pathway that controls adhesion-dependent exit of neuronal progenitors or immature neurons from a germinal zone niche, [RefSeq, PubMed]; Results from loss-of-function experiments do not support a general role for Siah genes in p53-mediated responses or mitosis., [RefSeq, PubMed]; Siah1 is a binding partner for POSH (plenty of SH3s), a scaffold component of the apoptotic JNK pathway, [RefSeq, PubMed]; This gene encodes a member of the seven in absentia homolog (Siah) family of E3 ubiquitin ligase enzymes that catalyze the transfer of ubiquitin to substrate proteins. The encoded protein targets Pard3A (partitioning defective 3A) protein for proteasome-mediated degradation during the exit of cerebellar granule neurons from their germinal zone niche. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPV6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0051402 neuron apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q06985-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53784-1", "uniprot_id": "SOX3_MOUSE", "mass": 37789.0, "length": 375, "protein_name": "Transcription factor SOX-3", "gene_name": "Sox3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sox3; Sox-3", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor SOX-3", "protein_names_refseq": "", "tax_id": 10090, "disease": "X-linked panhypopituitarism (Disease Ontology:DOID:0111779); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:20675); (R-MMU-3769402)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12748963;14981518;15456859;16167084;17728342;21183788;21750661;8625802", "class_list": "", "function": "Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80XF1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0007530 sex determination;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030900 forebrain development;GO:0045665 negative regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53784-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V172-1", "uniprot_id": "SE1L2_MOUSE", "mass": 77989.0, "length": 688, "protein_name": "Protein sel-1 homolog 2", "gene_name": "Sel1l2", "organism": "Mouse", "refseq_name": "protein sel-1 homolog 2 isoform 1 precursor", "refseq_ac": "NP_001028468", "gene_names_uniprotkb": "Sel1l2; Gm118", "gene_names_refseq": "Gm118; Sel1l2", "protein_names_uniprotkb": "Protein sel-1 homolog 2; Sel-1L2; Suppressor of lin-12-like protein 2", "protein_names_refseq": "protein sel-1 homolog 2 isoform 1 precursor; protein sel-1 homolog 2; sel-1L2; suppressor of lin-12-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:228684)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AHP5;B0QZY0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0016607 nuclear speck;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3V172-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04891-1", "uniprot_id": "SOX13_MOUSE", "mass": 68168.0, "length": 613, "protein_name": "Transcription factor SOX-13", "gene_name": "Sox13", "organism": "Mouse", "refseq_name": "transcription factor SOX-13 isoform 2", "refseq_ac": "NP_035569", "gene_names_uniprotkb": "Sox13; Sox-13", "gene_names_refseq": "Sox-13; Sox13", "protein_names_uniprotkb": "Transcription factor SOX-13; SRY (Sex determining region Y)-box 13; mSox13", "protein_names_refseq": "SRY-box containing gene 13; transcription factor SOX-13 isoform 2; transcription factor SOX-13", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); heart disease (Disease Ontology:DOID:114)", "pathway": " (mmu:20668); (R-MMU-3769402)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10871192;16835393;17218525;20028982;21750661;23562159;26525805;27923061;30413363;30638933;36852467;8441686;9421502;9524265", "class_list": "", "function": "Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:9421502, PubMed:9524265). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (PubMed:26525805). Binds to the gene promoter of MBP and acts as a transcriptional repressor (PubMed:26525805). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (PubMed:17218525, PubMed:23562159, PubMed:30413363). Required for the differentiation of Vgamma2-positive gamma-delta T-cells, a subset of IL17A expressing gamma-delta T-cells (PubMed:23562159). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (PubMed:23562159). Promotes brown adipocyte differentiation (PubMed:27923061). Inhibitor of WNT signaling (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q922L3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q04891-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1U8D0-1", "uniprot_id": "MTCL2_MOUSE", "mass": 183145.0, "length": 1654, "protein_name": "Microtubule cross-linking factor 2", "gene_name": "Mtcl2", "organism": "Mouse", "refseq_name": "microtubule cross-linking factor 2", "refseq_ac": "NP_001158135", "gene_names_uniprotkb": "Mtcl2; Soga1; Soga", "gene_names_refseq": "9830001H06Rik; D430036N24Rik; Mtcl2; Soga1; Soga", "protein_names_uniprotkb": "Microtubule cross-linking factor 2; SOGA family member 1; Suppressor of glucose by autophagy; Suppressor of glucose, autophagy-associated protein 1", "protein_names_refseq": "SOGA family member 1; microtubule cross-linking factor 2; protein SOGA1; suppressor of glucose by autophagy; suppressor of glucose, autophagy associated 1; suppressor of glucose, autophagy-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:320706)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20813965;25428506;28550165;30084848;35543016", "class_list": "", "function": "Microtubule-associated factor that enables integration of the centrosomal and Golgi-associated microtubules on the Golgi membrane, supporting directional migration. Preferentially acts on the perinuclear microtubules accumulated around the Golgi. Associates with the Golgi membrane through the N-terminal coiled-coil region and directly binds microtubules through the C-terminal domain (PubMed:35543016). Required for faithful chromosome segregation during mitosis (By similarity). Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner (PubMed:20813965)., [UniProtKB, UniProtKB, PubMed, PubMed]; The novel protein SOGA1 was confirmed to colocalize with a microtubule-associated protein CLASP2 and with tubulin, which identifies SOGA1 as a new microtubule-associated protein., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ACV6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005874 microtubule;GO:0030496 midbody", "go_biological_process": "GO:0007059 chromosome segregation;GO:0010506 regulation of autophagy;GO:0051301 cell division;GO:0008286 insulin receptor signaling pathway;GO:0045721 negative regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E1U8D0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58006-1", "uniprot_id": "SESN1_MOUSE", "mass": 56637.0, "length": 492, "protein_name": "Sestrin-1", "gene_name": "Sesn1", "organism": "Mouse", "refseq_name": "sestrin-1 isoform 2", "refseq_ac": "NP_001013388", "gene_names_uniprotkb": "Sesn1; Pa26; Sest1", "gene_names_refseq": "1110002G11Rik; Pa26; Sesn1; Sest1", "protein_names_uniprotkb": "Sestrin-1; 1.11.1.-", "protein_names_refseq": "p53 regulated Pa26 nuclear protein; p53-regulated protein PA26; sestrin-1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:140742); (R-MMU-5628897); (R-MMU-9639288); (R-MMU-9755511)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "11695551;12607115;18692468;21750661;25259925;31219806;34428180;34880414;35043753;35771919;36210013;38297375", "class_list": "", "function": "Forkhead box protein 1 transcriptionally activates sestrin1 to alleviate oxidized low-density lipoprotein-induced inflammation and lipid accumulation in macrophages., [RefSeq, PubMed]; Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25259925). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed (By similarity)., [UniProtKB, UniProtKB, PubMed]; MiR-200c-3p targets SESN1 and represses the IL-6/AKT loop to prevent cholangiocyte activation and cholestatic liver fibrosis., [RefSeq, PubMed]; Sestrin1 and Sestrin2 therefore provide an important link between genotoxic stress, p53 and the mTOR signaling pathway. Erratum:[Cell. 2009 Jan 23;136(2):378], [RefSeq, PubMed]; Sestrin1, 2, and 3 are dispensable for female fertility in mice. Publication Status: Online-Only, [RefSeq, PubMed]; The enhanced tumor susceptibility of p53+/- mice has made them one of several transgenic mouse models that are being considered as substitutes for standard 2-year rodent carcinogenicity assays. Review article, [RefSeq, PubMed]; Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPK0;Q7TNF3", "ec_number_list": "1.11.1.24;7.1.2.2;1.11.1.-;2.3.2.27;2.3.2.32;2.7.11.1;2.7.11.26;2.7.11.31;3.6.5.-;2.1.1.-;2.7.10.2", "go_molecular_function": "GO:0016684 oxidoreductase activity, acting on peroxide as acceptor;GO:0070728 L-leucine binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0061700 GATOR2 complex", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0030308 negative regulation of cell growth;GO:0042149 cellular response to glucose starvation;GO:0016239 positive regulation of macroautophagy;GO:0072593 reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P58006-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08800-1", "uniprot_id": "SPB8_MOUSE", "mass": 42150.0, "length": 374, "protein_name": "Serpin B8", "gene_name": "Serpinb8", "organism": "Mouse", "refseq_name": "serpin B8 isoform 1", "refseq_ac": "NP_035589", "gene_names_uniprotkb": "Serpinb8", "gene_names_refseq": "CAP-2; CAP2; NK10; Serpinb8; Spi8; ovalbumin", "protein_names_uniprotkb": "Serpin B8", "protein_names_refseq": "serine (or cysteine) peptdiase inhibitor, clade B, member 8; serine (or cysteine) proteinase inhibitor, clade B, member 8; serine protease inhibitor 8; serpin B8 isoform 1; serpin B8", "tax_id": 10090, "disease": "peeling skin syndrome 5 (Disease Ontology:DOID:0070524)", "pathway": " (mmu:20725); (R-MMU-75205)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11863365;18250455;21750661;34428180", "class_list": "", "function": "Has an important role in epithelial desmosome-mediated cell-cell adhesion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010951 negative regulation of endopeptidase activity;GO:0090136 epithelial cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O08800-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXL6-1", "uniprot_id": "SENP5_MOUSE", "mass": 86100.0, "length": 749, "protein_name": "Sentrin-specific protease 5", "gene_name": "Senp5", "organism": "Mouse", "refseq_name": "sentrin-specific protease 5 isoform 1", "refseq_ac": "NP_796077", "gene_names_uniprotkb": "Senp5; Smt3ip3", "gene_names_refseq": "6230429P13Rik; A730063F07Rik; SMT3IP3; Senp5", "protein_names_uniprotkb": "Sentrin-specific protease 5; 3.4.22.-; SUMO/Smt3-specific isopeptidase 3; Sentrin/SUMO-specific protease SENP5; Smt3ip3", "protein_names_refseq": "SUMO/Smt3-specific isopeptidase 3; SUMO/sentrin specific protease 5; sentrin-specific protease 5 isoform 1; sentrin-specific protease 5; sentrin/SUMO-specific protease SENP5", "tax_id": 10090, "disease": "", "pathway": " (mmu:320213); (R-MMU-3065679)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;29277914;31219806", "class_list": "", "function": "In the present study demonstrate for the first time that SENP5 are ubiquitously distributed in the adult murine brain., [RefSeq, PubMed]; Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZTK4;Q8BXW0", "ec_number_list": "3.4.22.-", "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0070139 SUMO-specific endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0099523 presynaptic cytosol;GO:0099524 postsynaptic cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0051301 cell division;GO:0016926 protein desumoylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NXL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70493-1", "uniprot_id": "SNX12_MOUSE", "mass": 19116.0, "length": 165, "protein_name": "Sorting nexin-12", "gene_name": "Snx12", "organism": "Mouse", "refseq_name": "sorting nexin-12 isoform 3", "refseq_ac": "NP_061363", "gene_names_uniprotkb": "Snx12", "gene_names_refseq": "2610001F05Rik; SDP8; Snx12", "protein_names_uniprotkb": "Sorting nexin-12; SDP8 protein", "protein_names_refseq": "sorting nexin-12 isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:55988)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;21183079;22109349;28011936;34428180;37828378", "class_list": "", "function": "May be involved in several stages of intracellular trafficking., [UniProtKB]; These results suggest that SNX12 regulates neurite formation during cerebral cortical development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D0N3", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0031901 early endosome membrane;GO:0030904 retromer complex", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0015031 protein transport;GO:0030100 regulation of endocytosis;GO:0042177 negative regulation of protein catabolic process;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70493-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88745-1", "uniprot_id": "SCRG1_MOUSE", "mass": 11173.0, "length": 98, "protein_name": "Scrapie-responsive protein 1", "gene_name": "Scrg1", "organism": "Mouse", "refseq_name": "scrapie-responsive protein 1 precursor", "refseq_ac": "NP_033162", "gene_names_uniprotkb": "Scrg1", "gene_names_refseq": "Scrg1", "protein_names_uniprotkb": "Scrapie-responsive protein 1; ScRG-1; Scrapie-responsive gene 1 protein", "protein_names_refseq": "scRG-1; scrapie responsive protein one; scrapie-responsive gene 1 protein; scrapie-responsive protein 1 precursor; scrapie-responsive protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20284)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14622145;16029203;9516475;9660755", "class_list": "", "function": "Scrg1 is associated with the secretory pathway of neuronal cells., [RefSeq, PubMed]; Taken together, our results indicate that Scrg1 is associated with neurodegenerative processes in TSE, but is not directly linked to dysregulation of prion protein., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0044306 neuron projection terminus", "go_biological_process": "GO:0097168 mesenchymal stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88745-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DP59-1", "uniprot_id": "SLUR2_MOUSE", "mass": 10452.0, "length": 97, "protein_name": "Secreted Ly-6/uPAR domain-containing protein 2", "gene_name": "Slurp2", "organism": "Mouse", "refseq_name": "secreted Ly-6/uPAR domain-containing protein 2 precursor", "refseq_ac": "NP_001075430", "gene_names_uniprotkb": "Slurp2", "gene_names_refseq": "2300005B03Rik; SLURP-2; Slurp2", "protein_names_uniprotkb": "Secreted Ly-6/uPAR domain-containing protein 2; SLURP-2", "protein_names_refseq": "secreted Ly-6/uPAR domain-containing protein 2 precursor; secreted Ly-6/uPAR domain-containing protein 2; secreted Ly-6/uPAR-related protein 2; secreted Ly6/uPAR related protein-2", "tax_id": 10090, "disease": "palmoplantar keratosis (Disease Ontology:DOID:3390)", "pathway": " (mmu:69462)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17286989;38866482", "class_list": "", "function": "Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs, strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner., [UniProtKB, UniProtKB]; Pain Hypersensitivity in SLURP1 and SLURP2 Knock-out Mouse Models of Hereditary Palmoplantar Keratoderma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08EF7;Q3TRB5;Q9WVC2", "ec_number_list": "", "go_molecular_function": "GO:0030548 acetylcholine receptor regulator activity;GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway;GO:0043616 keratinocyte proliferation;GO:0099601 regulation of neurotransmitter receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0DP59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40646-1", "uniprot_id": "SOX7_MOUSE", "mass": 41489.0, "length": 380, "protein_name": "Transcription factor SOX-7", "gene_name": "Sox7", "organism": "Mouse", "refseq_name": "transcription factor SOX-7", "refseq_ac": "NP_035576", "gene_names_uniprotkb": "Sox7; Sox-7", "gene_names_refseq": "Sox7", "protein_names_uniprotkb": "Transcription factor SOX-7; mSOX7", "protein_names_refseq": "SRY-box containing gene 7; mSOX7; transcription factor SOX-7", "tax_id": 10090, "disease": "congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (mmu:20680); (R-MMU-3769402)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10320775;11691915;15082719;1614875;19489079;19801444;22492353;39126242", "class_list": "", "function": "Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors. May be required for the survival of both hematopoietic and endothelial precursors during specification. May play a role in skeletal myogenesis and up-regulate the expression of muscle markers, such as PAX3/PAX7 and Meox1. Competes with GATA4 for binding and activation of the FGF3 promoter. Represses Wnt/beta-catenin-stimulated transcription. Probably acts by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Comparison with human gene, chromosome mapping, gene expression, transactivation domain, [RefSeq, PubMed]; System analysis based on weighted gene co-expression analysis identifies SOX7 as a novel regulator of hepatic stellate cell activation and liver fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1T6", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P40646-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60041-1", "uniprot_id": "SMS_MOUSE", "mass": 12746.0, "length": 116, "protein_name": "Somatostatin", "gene_name": "Sst", "organism": "Mouse", "refseq_name": "somatostatin precursor", "refseq_ac": "NP_033241", "gene_names_uniprotkb": "Sst; Smst", "gene_names_refseq": "SOM; SRIF; SS; Smst; Sst", "protein_names_uniprotkb": "Somatostatin", "protein_names_refseq": "preprosomatostatin; somatostatin precursor", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (mmu:20604); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "18753129;1969620;24735892;25012062;26561648", "class_list": "", "function": "Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin., [UniProtKB, UniProtKB]; May enhance low-glucose-induced glucagon release by pancreatic alpha cells (PubMed:24735892). This effect may be mediated by binding to GPR107 and PKA activation (PubMed:26561648). May regulate cardiac contractile function (PubMed:25012062). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH (By similarity). Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P01167", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005179 hormone activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol", "go_biological_process": "GO:0048545 response to steroid hormone;GO:0030334 regulation of cell migration;GO:0009410 response to xenobiotic stimulus;GO:0010447 response to acidic pH;GO:0043200 response to amino acid", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P60041-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62317-1", "uniprot_id": "SMD2_MOUSE", "mass": 13527.0, "length": 118, "protein_name": "Small nuclear ribonucleoprotein Sm D2", "gene_name": "Snrpd2", "organism": "Mouse", "refseq_name": "small nuclear ribonucleoprotein Sm D2", "refseq_ac": "NP_081219", "gene_names_uniprotkb": "Snrpd2", "gene_names_refseq": "1810009A06Rik; SMD2; Snrpd2", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein Sm D2; Sm-D2; snRNP core protein D2", "protein_names_refseq": "sm-D2; small nuclear ribonucleoprotein Sm D2; snRNP core protein D2", "tax_id": 10090, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:107686); (R-MMU-191859); (R-MMU-72163); (R-MMU-72165); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "21183079;23386199;34428180;39627609", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P43330", "ec_number_list": "", "go_molecular_function": "GO:1990446 U1 snRNP binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0034709 methylosome", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P62317-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97353-1", "uniprot_id": "SEC1_MOUSE", "mass": 41464.0, "length": 368, "protein_name": "Galactoside 2-alpha-L-fucosyltransferase Sec1", "gene_name": "Sec1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sec1; Fut3", "gene_names_refseq": "", "protein_names_uniprotkb": "Galactoside 2-alpha-L-fucosyltransferase Sec1; 2.4.1.-; Alpha(1,2)FT 3; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 3; Secretory blood group protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "11018479;11323419", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of alpha 1,2-linked fucose to ganglioside GM1 and galacto-N-biose (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q91V73;Q920T3;Q920T4", "ec_number_list": "2.4.1.344;2.4.1.69;2.4.1.-", "go_molecular_function": "GO:0008417 fucosyltransferase activity;GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0010595 positive regulation of endothelial cell migration;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 1540, "hit_score": 0.3, "record_id": "P97353-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TYX3-1", "uniprot_id": "SMYD5_MOUSE", "mass": 47095.0, "length": 416, "protein_name": "Protein-lysine N-trimethyltransferase SMYD5", "gene_name": "Smyd5", "organism": "Mouse", "refseq_name": "protein-lysine N-trimethyltransferase SMYD5", "refseq_ac": "NP_659167", "gene_names_uniprotkb": "Smyd5; Rai15", "gene_names_refseq": "NN8-4AG; Rai15; Rrg1; Smyd5", "protein_names_uniprotkb": "Protein-lysine N-trimethyltransferase SMYD5; 2.1.1.-; 2.1.1.359; 2.1.1.372; Protein NN8-4AG; Retinoic acid-induced protein 15; SET and MYND domain-containing protein 5; [histone H3]-lysine20 N-trimethyltransferase SMYD5; [histone H4]-lysine36 N-trimethyltransferase SMYD5", "protein_names_refseq": "SET and MYND domain-containing protein 5; [histone H3]-lysine20 N-trimethyltransferase SMYD5; [histone H4]-lysine20 N-trimethyltransferase SMYD5; [histone H4]-lysine36 N-trimethyltransferase SMYD5; histone-lysine N-trimethyltransferase SMYD5; protein-lysine N-trimethyltransferase SMYD5; retinoic acid induced 15; retinoic acid responsive gene 1; retinoic acid-induced protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:232187)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;22921934;28250819;28951459;35680905;39083378;8754834", "class_list": "", "function": "Protein-lysine N-trimethyltransferase that specifically catalyzes trimethylation of 'Lys-22' of the RPL40/eL40 subunit of the 60S ribosome, thereby promoting translation elongation and protein synthesis (By similarity). May also act as a histone methyltransferase in the context of histone octamers, but not on nucleosome substrates: trimethylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 to form H3K36me3 and H4K20me3, respectively (PubMed:22921934, PubMed:28250819, PubMed:35680905, PubMed:39083378). The histone methyltransferase activity, which is independent of its SET domain, is however unsure in vivo (By similarity). In association with the NCoR corepressor complex, involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages, possibly by catalyzing the formation of H4K20me3 at the gene promoters (PubMed:22921934). Plays an important role in embryonic stem (ES) cell self-renewal and differentiation (PubMed:28951459). Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by promoting H4K20me3 marks (PubMed:28250819). Acts as a regulator of the hypothermia response: its degradation in response to mild hypothermia relieves the formation of H3K36me3 at gene promoters, allowing expression of the neuroprotective gene SP1 (PubMed:39083378)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRB2;Q91YL6", "ec_number_list": "2.1.1.-;2.1.1.359;2.1.1.372;2.1.1.367;2.1.1.355;2.1.1.354;2.1.1.362;2.1.1.361", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016279 protein-lysine N-methyltransferase activity;GO:0042799 histone H4K20 methyltransferase activity;GO:0140955 histone H3K36 trimethyltransferase activity;GO:0140943 histone H4K20 trimethyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045814 negative regulation of gene expression, epigenetic;GO:0032259 methylation;GO:2000035 regulation of stem cell division;GO:0002181 cytoplasmic translation;GO:2000736 regulation of stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3TYX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UKJ7-1", "uniprot_id": "SMU1_MOUSE", "mass": 57544.0, "length": 513, "protein_name": "WD40 repeat-containing protein SMU1", "gene_name": "Smu1", "organism": "Mouse", "refseq_name": "WD40 repeat-containing protein SMU1", "refseq_ac": "NP_067510", "gene_names_uniprotkb": "Smu1", "gene_names_refseq": "2600001O03Rik; 2610203K23Rik; Bwd; Smu1", "protein_names_uniprotkb": "WD40 repeat-containing protein SMU1; Smu-1 suppressor of mec-8 and unc-52 protein homolog", "protein_names_refseq": "WD40 repeat-containing protein SMU1; smu-1 suppressor of mec-8 and unc-52 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:74255); (R-MMU-72163)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15031102;25605945;31219806;33300544;34428180", "class_list": "", "function": "Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PFR6;Q8BMY4;Q9D1I8;Q9JJ70", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0071011 precatalytic spliceosome;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UKJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IUP1-1", "uniprot_id": "SOLH1_MOUSE", "mass": 38188.0, "length": 357, "protein_name": "Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1", "gene_name": "Sohlh1", "organism": "Mouse", "refseq_name": "spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 isoform 1", "refseq_ac": "NP_001001714", "gene_names_uniprotkb": "Sohlh1; Gm110; Tohlh1", "gene_names_refseq": "Gm110; Nohlh; Sohlh1", "protein_names_uniprotkb": "Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1", "protein_names_refseq": "helix-loop-helix protein NOHLH; spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 isoform 1; spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1", "tax_id": 10090, "disease": "ovarian dysgenesis 5 (Disease Ontology:DOID:0080497); spermatogenic failure 32 (Disease Ontology:DOID:0111925)", "pathway": " (mmu:227631)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16564520;16690745;20951351;22056784;28504655;32086523;36723967", "class_list": "", "function": "Findings substantiate a major role for FIGLA, LHX8 and SOHLH1 as multifunctional regulators of networks necessary for oocyte maintenance and differentiation during early folliculogenesis., [RefSeq, PubMed]; Sohlh1 and Lhx8 are two germ cell-specific, critical regulators of oogenesis, [RefSeq, PubMed]; Sohlh1 loss of function male and female infertility model impacts overall health beyond gonadal dysfunction in micedagger., [RefSeq, PubMed]; Sohlh1 represents the first testis-specific bHLH transcription factor that is essential for spermatogonial differentiation., [RefSeq, PubMed]; Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation (PubMed:22056784). Coordinates oocyte differentiation without affecting meiosis I (PubMed:28504655)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RTA1", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009994 oocyte differentiation;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6IUP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P5C5-1", "uniprot_id": "SMUG1_MOUSE", "mass": 30654.0, "length": 279, "protein_name": "Single-strand selective monofunctional uracil DNA glycosylase", "gene_name": "Smug1", "organism": "Mouse", "refseq_name": "single-strand selective monofunctional uracil DNA glycosylase", "refseq_ac": "NP_082161", "gene_names_uniprotkb": "Smug1", "gene_names_refseq": "1200013B09Rik; A930006H09Rik; Smug1", "protein_names_uniprotkb": "Single-strand selective monofunctional uracil DNA glycosylase; 3.2.2.-", "protein_names_refseq": "single-strand selective monofunctional uracil DNA glycosylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:71726); (R-MMU-110329); (R-MMU-110357)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12820976;21750661;24771041;28775312;36244177", "class_list": "", "function": "Nonetheless, using a highly MSH2-dependent mechanism, Ung(-/-) Smug1(-/-) mice can still produce detectable levels of switched isotypes, especially IgG1, [RefSeq, PubMed]; Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration., [UniProtKB, UniProtKB]; SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice., [RefSeq, PubMed]; The structure and specificity of SMUG1 have been solved., [RefSeq, PubMed]; We showed that SMUG1 efficiently prevent genomic uracil accumulation, even in the presence of UNG, and identified mutational signatures associated with combined UNG and SMUG1 deficiency. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DBV1", "ec_number_list": "3.1.11.2;3.1.21.-;3.2.2.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0019104 DNA N-glycosylase activity;GO:0004844 uracil DNA N-glycosylase activity;GO:0003697 single-stranded DNA binding;GO:0017065 single-strand selective uracil DNA N-glycosylase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0006281 DNA repair;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6P5C5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UK0-1", "uniprot_id": "SESD1_MOUSE", "mass": 79376.0, "length": 696, "protein_name": "SEC14 domain and spectrin repeat-containing protein 1", "gene_name": "Sestd1", "organism": "Mouse", "refseq_name": "SEC14 domain and spectrin repeat-containing protein 1", "refseq_ac": "NP_780674", "gene_names_uniprotkb": "Sestd1", "gene_names_refseq": "1500031J16Rik; A930010O20; Sestd1; Solo/Trio8", "protein_names_uniprotkb": "SEC14 domain and spectrin repeat-containing protein 1; Huntingtin-interacting protein-like protein", "protein_names_refseq": "SEC14 domain and spectrin repeat-containing protein 1; huntingtin-interacting protein-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:228071)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16943433;18250455;23696638;25605945;29293918;32848054;34428180;34678516;37507081;40885482", "class_list": "", "function": "Data indicate that Sestd1 cooperates with Dact1 in Vangl2 regulation and in the planar cell polarity (PCP) pathway during mammalian embryonic development., [RefSeq, PubMed]; May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1 (By similarity)., [UniProtKB]; Sestd1 is a developmentally dynamic synaptic regulator of Rho GTPases that contributes to dendrite and excitatory synapse formation in the forebrain. Erratum:[Cereb Cortex. 2019 Mar 1;29(3):1217. doi: 10.1093/cercor/bhy026. PMID: 29474518], [RefSeq, PubMed]; These results suggest that Solo/Trio8 acts as an early-endosome-specific upstream activator of Rho family GTPases for neurite elongation of developing Purkinje neurons.[Trio8], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLJ1;Q810W3;Q8CI09", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0045111 intermediate filament cytoskeleton;GO:0034704 calcium channel complex", "go_biological_process": "GO:1904878 negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80UK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZJ7-1", "uniprot_id": "SNX32_MOUSE", "mass": 46647.0, "length": 404, "protein_name": "Sorting nexin-32", "gene_name": "Snx32", "organism": "Mouse", "refseq_name": "sorting nexin-32 isoform 1", "refseq_ac": "NP_001019731", "gene_names_uniprotkb": "Snx32; Snx6b", "gene_names_refseq": "B930037P14Rik; Snx32; Snx6b", "protein_names_uniprotkb": "Sorting nexin-32; Sorting nexin-6B", "protein_names_refseq": "sortin nexin-6B; sorting nexin-32 isoform 1; sorting nexin-6B", "tax_id": 10090, "disease": "", "pathway": " (mmu:225861)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25605945;37158588", "class_list": "", "function": "Involved in endosomal trafficking of cargo proteins, including transferrin-bound transferrin receptor (TFRC), cation-independent mannose-6-phosphate receptor (IGF2R) and epidermal growth factor receptor (EGFR). Functions redundantly with other BAR domain-containing sorting nexins in endosome to trans-Golgi network transport of IGF2R. Regulates in coordination with SNX5 sorting and trafficking of EGF-activated EGFR to multivesicular bodies for lysosomal degradation (By similarity). Plays an essential role in neurite outgrowth, controlling basigin/EMMPRIN (BSG) trafficking to the cell surface (PubMed:37158588)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0015031 protein transport;GO:0016197 endosomal transport;GO:0042147 retrograde transport, endosome to Golgi;GO:1990138 neuron projection extension;GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80ZJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIH0-1", "uniprot_id": "SP130_MOUSE", "mass": 111228.0, "length": 1057, "protein_name": "Histone deacetylase complex subunit SAP130", "gene_name": "Sap130", "organism": "Mouse", "refseq_name": "histone deacetylase complex subunit SAP130 isoform 1", "refseq_ac": "NP_766553", "gene_names_uniprotkb": "Sap130", "gene_names_refseq": "2610304F09Rik; 6720406D06; Sap130", "protein_names_uniprotkb": "Histone deacetylase complex subunit SAP130; 130 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p130", "protein_names_refseq": "130 kDa Sin3-associated polypeptide; Sin3A associated protein, 130kDa; histone deacetylase complex subunit SAP130 isoform 1; histone deacetylase complex subunit SAP130; sin3-associated polypeptide p130", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (mmu:269003)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "18776906;21183079;21606357;21750661;22517741;22872234;32782141;32848054;34428180;34678516;35820727;36852467;38320352;38861834;39627609;40021952;40885482;40997131", "class_list": "", "function": "Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity)., [UniProtKB]; SAP130 released by ferroptosis tubular epithelial cells promotes macrophage polarization via Mincle signaling in sepsis acute kidney injury., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 25, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 25, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 25, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 27, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZP5;Q6P553;Q8BID9;Q9CSU1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0070822 Sin3-type complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "Q8BIH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQM7-1", "uniprot_id": "SMCO3_MOUSE", "mass": 24787.0, "length": 225, "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 3", "gene_name": "Smco3", "organism": "Mouse", "refseq_name": "single-pass membrane and coiled-coil domain-containing protein 3", "refseq_ac": "NP_001034647", "gene_names_uniprotkb": "Smco3", "gene_names_refseq": "C030030A07Rik; Smco3", "protein_names_uniprotkb": "Single-pass membrane and coiled-coil domain-containing protein 3", "protein_names_refseq": "single-pass membrane and coiled-coil domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:654818)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNZ4;Q8BR60", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BQM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTE0-1", "uniprot_id": "SDHF4_MOUSE", "mass": 11889.0, "length": 104, "protein_name": "Succinate dehydrogenase assembly factor 4, mitochondrial", "gene_name": "Sdhaf4", "organism": "Mouse", "refseq_name": "succinate dehydrogenase assembly factor 4, mitochondrial precursor", "refseq_ac": "NP_080779", "gene_names_uniprotkb": "Sdhaf4", "gene_names_refseq": "1110058L19Rik; 1700001E18Rik; C6orf57; Sdhaf4", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 4, mitochondrial; SDH assembly factor 4; SDHAF4", "protein_names_refseq": "SDH assembly factor 4; UPF0369 protein C6orf57 homolog; succinate dehydrogenase assembly factor 4, mitochondrial precursor; succinate dehydrogenase assembly factor 4, mitochondrial", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:68002); (R-MMU-9854311)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "24954416;35803927", "class_list": "", "function": "Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy. Erratum:[Nat Commun. 2022 Aug 10;13(1):4690. doi: 10.1038/s41467-022-32492-w. PMID: 35948556] Publication Status: Online-Only, [RefSeq, PubMed]; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit Sdha in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit Sdhb into the SDH catalytic dimer (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQN5;Q9D537", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0045087 innate immune response;GO:1904231 positive regulation of succinate dehydrogenase activity;GO:0034553 mitochondrial respiratory chain complex II assembly;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BTE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BX51-1", "uniprot_id": "SGCZ_MOUSE", "mass": 34461.0, "length": 311, "protein_name": "Zeta-sarcoglycan", "gene_name": "Sgcz", "organism": "Mouse", "refseq_name": "zeta-sarcoglycan", "refseq_ac": "NP_665840", "gene_names_uniprotkb": "Sgcz", "gene_names_refseq": "C230085N17Rik; Sgcz", "protein_names_uniprotkb": "Zeta-sarcoglycan; ZSG1; Zeta-SG", "protein_names_refseq": "ZSG1; zeta-SG; zeta-sarcoglycan", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); dilated cardiomyopathy 1L (Disease Ontology:DOID:0110436); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:244431); (R-MMU-9913351)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;12189167;21750661", "class_list": "", "function": "Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability., [UniProtKB]; Zeta-sarcoglycan is an integral component of the sarcoglycan complex and is important in the pathogenesis of muscular dystrophy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVZ2;Q8K1E7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0042383 sarcolemma;GO:0016012 sarcoglycan complex", "go_biological_process": "GO:0060047 heart contraction;GO:0061024 membrane organization;GO:0048738 cardiac muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BX51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0V7-1", "uniprot_id": "SMKW_MOUSE", "mass": 55407.0, "length": 499, "protein_name": "Putative sperm motility kinase W", "gene_name": "Stk-ps2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Stk-ps2; Gm4776", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative sperm motility kinase W; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PV11", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0042149 cellular response to glucose starvation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8C0V7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C110-1", "uniprot_id": "SLIK6_MOUSE", "mass": 95056.0, "length": 840, "protein_name": "SLIT and NTRK-like protein 6", "gene_name": "Slitrk6", "organism": "Mouse", "refseq_name": "SLIT and NTRK-like protein 6 precursor", "refseq_ac": "NP_780708", "gene_names_uniprotkb": "Slitrk6; Sltk6", "gene_names_refseq": "4832410J21Rik; Slitrk6; Sltk6", "protein_names_uniprotkb": "SLIT and NTRK-like protein 6", "protein_names_refseq": "SLIT and NTRK-like protein 6 precursor; SLIT and NTRK-like protein 6; neuronal transmembrane protein Slitrk6; slit and trk like gene 6", "tax_id": 10090, "disease": "high myopia-sensorineural deafness syndrome (Disease Ontology:DOID:0111628); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (mmu:239250); (R-MMU-388844)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;14550773;14643680;19936227;21298075;23543054;34203471", "class_list": "", "function": "Regulator of neurite outgrowth required for normal hearing and vision., [UniProtKB, PubMed, PubMed]; Slitrk6 gene expression profile in the mouse embryo., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLL0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0060005 vestibular reflex;GO:0060384 innervation;GO:0031223 auditory behavior;GO:0001964 startle response;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8C110-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BML9-1", "uniprot_id": "SYQ_MOUSE", "mass": 87677.0, "length": 775, "protein_name": "Glutamine--tRNA ligase", "gene_name": "Qars1", "organism": "Mouse", "refseq_name": "glutamine--tRNA ligase", "refseq_ac": "NP_598555", "gene_names_uniprotkb": "Qars1; Qars", "gene_names_refseq": "1110018N24Rik; 1200016L19Rik; GLNRS; Qars1; Qars", "protein_names_uniprotkb": "Glutamine--tRNA ligase; 6.1.1.18; GlnRS; Glutaminyl-tRNA synthetase", "protein_names_refseq": "glutamine--tRNA ligase; glutamine-tRNA ligase", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (mmu:97541); (R-MMU-9856649)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12060739;17242355;21183079;21750661;25428506;28528544;30779550;34428180;39627609", "class_list": "", "function": "Glutamine--tRNA ligase. Plays a critical role in brain development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TN94;Q8BU21", "ec_number_list": "2.7.10.1;2.7.11.24;6.1.1.10;6.1.1.4;6.1.1.18;6.1.1.5;6.1.1.12;2.7.7.-;6.1.1.6;6.1.1.19", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0004860 protein kinase inhibitor activity;GO:0004819 glutamine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0007420 brain development;GO:2001234 negative regulation of apoptotic signaling pathway;GO:0006425 glutaminyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BML9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0K0-1", "uniprot_id": "TBCD7_MOUSE", "mass": 33826.0, "length": 293, "protein_name": "TBC1 domain family member 7", "gene_name": "Tbc1d7", "organism": "Mouse", "refseq_name": "TBC1 domain family member 7 isoform 1", "refseq_ac": "NP_001239568", "gene_names_uniprotkb": "Tbc1d7", "gene_names_refseq": "2610009C09Rik; Tbc1d7", "protein_names_uniprotkb": "TBC1 domain family member 7", "protein_names_refseq": "TBC1 domain family member 7 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67046); (R-MMU-8854214)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;22795129;22872234;31219806;34428180;35584673", "class_list": "", "function": "Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:22795129). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (By similarity). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNC1;Q05AE0;Q3U0V0", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0062078 TSC1-TSC2 complex binding", "go_cellular_component": "GO:0033596 TSC1-TSC2 complex;GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0031410 cytoplasmic vesicle;GO:0036064 ciliary basal body", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0043547 positive regulation of GTPase activity;GO:0031398 positive regulation of protein ubiquitination;GO:0032007 negative regulation of TOR signaling;GO:0070848 response to growth factor", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D0K0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9R3-1", "uniprot_id": "SPAT9_MOUSE", "mass": 28482.0, "length": 252, "protein_name": "Spermatogenesis-associated protein 9", "gene_name": "Spata9", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 9", "refseq_ac": "NP_083619", "gene_names_uniprotkb": "Spata9", "gene_names_refseq": "1700030K01Rik; 4930599C08Rik; A930023H06Rik; Spata9", "protein_names_uniprotkb": "Spermatogenesis-associated protein 9", "protein_names_refseq": "spermatogenesis-associated protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:75571)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12493713;21750661", "class_list": "", "function": "May play at role in testicular development/spermatogenesis and may be an important factor in male infertility., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D4M8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D9R3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70422-1", "uniprot_id": "TF2H4_MOUSE", "mass": 52224.0, "length": 463, "protein_name": "General transcription factor IIH subunit 4", "gene_name": "Gtf2h4", "organism": "Mouse", "refseq_name": "general transcription factor IIH subunit 4 isoform 1", "refseq_ac": "NP_034494", "gene_names_uniprotkb": "Gtf2h4", "gene_names_refseq": "BTF2 p52; Gtf2h4; p52", "protein_names_uniprotkb": "General transcription factor IIH subunit 4; BTF2 p52; Basic transcription factor 2 52 kDa subunit; General transcription factor IIH polypeptide 4; TFIIH basal transcription factor complex p52 subunit", "protein_names_refseq": "TFIIH basal transcription factor complex p52 subunit; basic transcription factor 2 52 kDa subunit; general transcription factor IIH subunit 4 isoform 1; general transcription factor IIH subunit 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:14885); (R-MMU-112382); (R-MMU-113418); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-72086); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075)", "pathway_count": 20, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription., [UniProtKB, UniProtKB]; This gene encodes a subunit of the general transcription factor multiprotein complex that plays roles in basal transcription, DNA repair and cell cycle control. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0001671 ATPase activator activity;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005675 transcription factor TFIIH holo complex;GO:0005669 transcription factor TFIID complex;GO:0000438 core TFIIH complex portion of holo TFIIH complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006289 nucleotide-excision repair;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70422-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P80314-1", "uniprot_id": "TCPB_MOUSE", "mass": 57477.0, "length": 535, "protein_name": "T-complex protein 1 subunit beta", "gene_name": "Cct2", "organism": "Mouse", "refseq_name": "T-complex protein 1 subunit beta", "refseq_ac": "NP_031662", "gene_names_uniprotkb": "Cct2; Cctb", "gene_names_refseq": "Cct2; Cctb", "protein_names_uniprotkb": "T-complex protein 1 subunit beta; 3.6.1.-; CCT-beta; TCP-1-beta", "protein_names_refseq": "CCT-beta; T-complex protein 1 subunit beta; TCP-1-beta; chaperonin containing Tcp1, subunit 2 (beta); chaperonin subunit 2 (beta)", "tax_id": 10090, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791); candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:12461); (R-MMU-390471); (R-MMU-5620922); (R-MMU-6798695); (R-MMU-6814122); (R-MMU-9013418); (R-MMU-9013422)", "pathway_count": 7, "publication_count": 27, "publication_id_list": "10336634;19332537;21540332;21750661;22645316;24788674;25153642;25428506;25605945;26740625;28135057;28528544;29187734;30084848;31219806;33300544;34428180;34887587;35366418;36792666;37453647;37507081;37828378;38830954;39627609;39927985;7953530", "class_list": "", "function": "CCT2 is an aggrephagy receptor for clearance of solid protein aggregates., [RefSeq, PubMed]; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia., [UniProtKB, UniProtKB]; Compound heterozygous mutations in a mouse model of Leber congenital amaurosis reveal the role of CCT2 in photoreceptor maintenance. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1U0", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;4.6.1.19;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;1.11.1.27;3.1.1.4;2.3.1.23;3.1.-.-;3.2.1.24;4.6.1.18;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.2.1.17;3.1.3.1;3.9.1.1;1.11.2.2;3.6.1.-;3.2.1.31;3.4.16.5;3.4.16.-;3.2.1.52;5.6.2.5;4.2.99.18;3.2.1.23;3.6.4.12;5.6.1.6;3.4.21.20;2.7.10.2;2.7.11.13;3.6.4.6;1.1.1.205;3.1.6.8;3.1.6.12;3.2.1.-;3.2.1.22;3.6.5.-;2.7.11.24;3.6.1.15;3.1.4.-;2.7.11.39;3.1.27.-;3.4.14.1;3.5.3.15;5.6.2.-;7.2.2.-;3.4.21.37;3.1.6.4;7.6.2.16;3.4.21.76;3.5.3.1;1.6.5.5;3.5.1.26;3.1.6.14;3.1.3.16;5.3.99.3;6.3.4.21;3.1.4.35;3.4.21.53;2.7.7.7;2.7.7.49;2.7.1.91;2.3.1.-;2.4.1.1;2.7.11.1;2.7.4.3;2.3.3.8;3.6.5.2;1.8.4.-;5.3.4.1;3.2.1.51;1.6.2.2;3.4.14.2;3.4.21.4;3.4.19.9", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0043209 myelin sheath;GO:0044297 cell body;GO:0097225 sperm midpiece", "go_biological_process": "GO:0090666 scaRNA localization to Cajal body;GO:0007339 binding of sperm to zona pellucida;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P80314-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U2A8-1", "uniprot_id": "SYVM_MOUSE", "mass": 118461.0, "length": 1060, "protein_name": "Valine--tRNA ligase, mitochondrial", "gene_name": "Vars2", "organism": "Mouse", "refseq_name": "valine--tRNA ligase, mitochondrial isoform 1 precursor", "refseq_ac": "NP_780346", "gene_names_uniprotkb": "Vars2; Kiaa1885; Vars2l", "gene_names_refseq": "1190004I24Rik; Vars2l; Vars2; mKIAA1885", "protein_names_uniprotkb": "Valine--tRNA ligase, mitochondrial; 6.1.1.9; ValRS; Valyl-tRNA synthetase", "protein_names_refseq": "valRS; valine--tRNA ligase, mitochondrial isoform 1 precursor; valine--tRNA ligase, mitochondrial; valyl-tRNA synthetase 2, mitochondrial (putative); valyl-tRNA synthetase, mitochondrial", "tax_id": 10090, "disease": "myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); combined oxidative phosphorylation deficiency 20 (Disease Ontology:DOID:0111478); mitochondrial metabolism disease (Disease Ontology:DOID:700); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (mmu:68915)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23576753;30084848;35820727", "class_list": "", "function": "Catalyzes the attachment of valine to tRNA(Val) in a two-step reaction: valine is first activated by ATP to form Val-AMP and then transferred to the acceptor end of tRNA(Val)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QMJ4;Q69Z78;Q6PGG3;Q6ZQL7;Q8BIN9", "ec_number_list": "6.1.1.9", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0004832 valine-tRNA ligase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006438 valyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3U2A8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R239-1", "uniprot_id": "TM268_MOUSE", "mass": 37763.0, "length": 342, "protein_name": "Transmembrane protein 268", "gene_name": "Tmem268", "organism": "Mouse", "refseq_name": "transmembrane protein 268", "refseq_ac": "NP_659154", "gene_names_uniprotkb": "Tmem268; 6330416G13Rik", "gene_names_refseq": "6330416G13Rik; Tmem268; bM230C2.2", "protein_names_uniprotkb": "Transmembrane protein 268", "protein_names_refseq": "transmembrane protein 268; transmembrane protein C9orf91 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:230279)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;38730209", "class_list": "", "function": "Deletion of Tmem268 in mice suppresses anti-infectious immune responses by downregulating CD11b signaling., [RefSeq, PubMed]; Stabilizes cell surface expression of ITGAM and participates in the adhesion and migration of phagocytes during bacterial clearance., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTV3;Q3UMC5;Q80VW1;Q80VW2;Q8BMN2;Q8C0I7;Q8CIJ7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R239-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BRH0-1", "uniprot_id": "TMTC3_MOUSE", "mass": 104198.0, "length": 920, "protein_name": "Protein O-mannosyl-transferase TMTC3", "gene_name": "Tmtc3", "organism": "Mouse", "refseq_name": "protein O-mannosyl-transferase TMTC3 isoform 2", "refseq_ac": "NP_001028504", "gene_names_uniprotkb": "Tmtc3", "gene_names_refseq": "9130014E20Rik; B130008E12Rik; Tmtc3; mSmile", "protein_names_uniprotkb": "Protein O-mannosyl-transferase TMTC3; 2.4.1.109; Transmembrane O-mannosyltransferase targeting cadherins 3; Transmembrane and tetratricopeptide repeat-containing 3", "protein_names_refseq": "protein O-mannosyl-transferase TMTC3 isoform 2; protein O-mannosyl-transferase TMTC3; transmembrane O-mannosyltransferase targeting cadherins 3; transmembrane and TPR repeat-containing protein 3", "tax_id": 10090, "disease": "lissencephaly 8 (Disease Ontology:DOID:0112233); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:237500)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;25428506;25428507;27773428;30899004;31599954;34203471;34428180;37828378", "class_list": "", "function": "Our data suggest that loss of TMTC3 causes cobblestone lissencephaly with minimal eye or muscle involvement., [RefSeq, PubMed]; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMN6", "ec_number_list": "2.4.1.109", "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0048286 lung alveolus development;GO:0030324 lung development;GO:0009791 post-embryonic development;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BRH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921W8-1", "uniprot_id": "SCT1A_MOUSE", "mass": 21438.0, "length": 192, "protein_name": "Secreted and transmembrane protein 1A", "gene_name": "Sectm1a", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sectm1a", "gene_names_refseq": "", "protein_names_uniprotkb": "Secreted and transmembrane protein 1A", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:209588)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0038110 interleukin-2-mediated signaling pathway;GO:0006955 immune response;GO:0002726 positive regulation of T cell cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q921W8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D123-1", "uniprot_id": "TM219_MOUSE", "mass": 25573.0, "length": 240, "protein_name": "Insulin-like growth factor-binding protein 3 receptor", "gene_name": "Tmem219", "organism": "Mouse", "refseq_name": "insulin-like growth factor-binding protein 3 receptor isoform 1 precursor", "refseq_ac": "NP_081103", "gene_names_uniprotkb": "Tmem219", "gene_names_refseq": "1110032O16Rik; 2900045G02Rik; IGFBP-3R; Tmem219", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 3 receptor; IGFBP-3R; Transmembrane protein 219", "protein_names_refseq": "insulin-like growth factor-binding protein 3 receptor isoform 1 precursor; insulin-like growth factor-binding protein 3 receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:68742); (R-MMU-6803211)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6H1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D123-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2RSY6-1", "uniprot_id": "TRM1L_MOUSE", "mass": 80861.0, "length": 728, "protein_name": "tRNA (guanine(27)-N(2))-dimethyltransferase", "gene_name": "Trmt1l", "organism": "Mouse", "refseq_name": "tRNA (guanine(27)-N(2))-dimethyltransferase isoform 1", "refseq_ac": "NP_081152", "gene_names_uniprotkb": "Trmt1l", "gene_names_refseq": "1190005F20Rik; C1orf25; Trm1-like; Trm1l; Trmt1l", "protein_names_uniprotkb": "tRNA (guanine(27)-N(2))-dimethyltransferase; 2.1.1.-; TRMT1-like protein; tRNA methyltransferase 1-like protein", "protein_names_refseq": "TRMT1-like protein; tRNA (guanine(27)-N(2))-dimethyltransferase isoform 1; tRNA (guanine(27)-N(2))-dimethyltransferase; tRNA methyltransferase 1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:98685)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17198746;20173027;21750661;28135057;31219806;34428180", "class_list": "", "function": "Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (By similarity). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (By similarity). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (By similarity). May play a role in motor coordination and exploratory behavior (PubMed:17198746)., [UniProtKB, UniProtKB, PubMed]; Trm1-like deficient mice are viable and show no anatomical defects; behavioural tests, however, revealed significantly altered motor coordination and aberrant exploratory behaviour thus, Trm1 plays a role in modulating postnatal neuronal functions., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGB9;Q3UFG1;Q3UKB0;Q8C2S4;Q8CI50;Q8R203;Q9CT68", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0016423 tRNA (guanine) methyltransferase activity;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0160248 tRNA (guanine(27)-N2)-dimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0002940 tRNA N2-guanine methylation;GO:0008033 tRNA processing;GO:0008344 adult locomotory behavior;GO:0030534 adult behavior;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A2RSY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1Q6-1", "uniprot_id": "T176B_MOUSE", "mass": 28367.0, "length": 263, "protein_name": "Transmembrane protein 176B", "gene_name": "Tmem176b", "organism": "Mouse", "refseq_name": "transmembrane protein 176B", "refseq_ac": "NP_001157679", "gene_names_uniprotkb": "Tmem176b; Clast1; Lr8", "gene_names_refseq": "1810009M01Rik; Clast1; Lr8; Tmem176b", "protein_names_uniprotkb": "Transmembrane protein 176B; Protein LR8", "protein_names_refseq": "transmembrane protein 176B", "tax_id": 10090, "disease": "", "pathway": " (mmu:65963)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16814752;19144319;21750661;29466738;34233909;34428180;37828378;9922225", "class_list": "", "function": "Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4(+) T Cells., [RefSeq, PubMed]; May play a role in the process of maturation of dendritic cells (By similarity). Required for the development of cerebellar granule cells., [UniProtKB, PubMed]; Myogenic differentiation is achieved through the specific interaction between Cry2 and Bclaf1, which stabilizes mRNAs encoding cyclin D1, a G1/S phase transition regulator, and Tmem176b, a transmembrane regulator for myogenic cell fusion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WU52", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0016020 membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:2001199 negative regulation of dendritic cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R1Q6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FW56-1", "uniprot_id": "T255B_MOUSE", "mass": 39392.0, "length": 369, "protein_name": "Transmembrane protein 255B", "gene_name": "Tmem255b", "organism": "Mouse", "refseq_name": "transmembrane protein 255B isoform 1", "refseq_ac": "NP_001137143", "gene_names_uniprotkb": "Tmem255b; Fam70b; Gm687", "gene_names_refseq": "Fam70b; Gm687; Tmem255b", "protein_names_uniprotkb": "Transmembrane protein 255B; Protein FAM70B", "protein_names_refseq": "family with sequence similarity 70, member B; protein FAM70B; transmembrane protein 255B isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:272465)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5FW56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJB9-1", "uniprot_id": "TM183_MOUSE", "mass": 42945.0, "length": 375, "protein_name": "Transmembrane protein 183", "gene_name": "Tmem183a; Tmem183", "organism": "Mouse", "refseq_name": "transmembrane protein 183 isoform b", "refseq_ac": "NP_001035950", "gene_names_uniprotkb": "Tmem183a; Tmem183; MNCb-2755; Tmem183a", "gene_names_refseq": "1300007B12Rik; 1700020N19Rik; Tmem183a; Tmem183", "protein_names_uniprotkb": "Transmembrane protein 183", "protein_names_refseq": "transmembrane protein 183 isoform b; transmembrane protein 183", "tax_id": 10090, "disease": "", "pathway": " (mmu:57439)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THC8;Q99LK6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UQ84-1", "uniprot_id": "SYTM_MOUSE", "mass": 81700.0, "length": 723, "protein_name": "Threonine--tRNA ligase, mitochondrial", "gene_name": "Tars2", "organism": "Mouse", "refseq_name": "threonine--tRNA ligase, mitochondrial isoform 2", "refseq_ac": "NP_001157089", "gene_names_uniprotkb": "Tars2; Tarsl1", "gene_names_refseq": "2610024N01Rik; Tars2; Tarsl1; thrRS", "protein_names_uniprotkb": "Threonine--tRNA ligase, mitochondrial; 6.1.1.3; ThrRS; Threonyl-tRNA synthetase-like 1; Threonyl-tRNA synthetase", "protein_names_refseq": "threonine--tRNA ligase, mitochondrial isoform 2; threonine--tRNA ligase, mitochondrial; threonyl-tRNA synthetase, mitochondrial; threonyl-tRNA synthetase-like 1", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 21 (Disease Ontology:DOID:0111465); nonphotosensitive trichothiodystrophy (Disease Ontology:DOID:0111867); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:71807)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;35184682", "class_list": "", "function": "Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain., [UniProtKB, UniProtKB]; Knockdown of mitochondrial threonyl-tRNA synthetase 2 inhibits lung adenocarcinoma cell proliferation and induces apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RW19;Q9D0D6", "ec_number_list": "6.1.1.3", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0004829 threonine-tRNA ligase activity;GO:0004812 aminoacyl-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006435 threonyl-tRNA aminoacylation;GO:0006412 translation;GO:0043039 tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UQ84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9I1-1", "uniprot_id": "SMI10_MOUSE", "mass": 16282.0, "length": 141, "protein_name": "Sperm-associated microtubule inner protein 10", "gene_name": "Spmip10", "organism": "Mouse", "refseq_name": "sperm-associated microtubule inner protein 10", "refseq_ac": "NP_080375", "gene_names_uniprotkb": "Spmip10; 1700065I17Rik; C5orf48; Tex43", "gene_names_refseq": "1700065I17Rik; Spmip10; Tex43; Tseg7", "protein_names_uniprotkb": "Sperm-associated microtubule inner protein 10; Testis-expressed protein 43", "protein_names_refseq": "sperm-associated microtubule inner protein 10; testis expressed 43; testis specific expressed protein 7; testis-expressed protein 43; testis-expressed sequence 43 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67343)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;34446558;37295417;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme, which is required for flagellum beating (PubMed:34446558, PubMed:37295417, PubMed:37989994). May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella (PubMed:34446558, PubMed:37295417). Involved in the regulation of sperm motility (PubMed:34446558)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0160112 axonemal B tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D9I1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62440-1", "uniprot_id": "TLE1_MOUSE", "mass": 83097.0, "length": 770, "protein_name": "Transducin-like enhancer protein 1", "gene_name": "Tle1", "organism": "Mouse", "refseq_name": "transducin-like enhancer protein 1 isoform c", "refseq_ac": "NP_001272459", "gene_names_uniprotkb": "Tle1; Grg1", "gene_names_refseq": "C230057C06Rik; Estm14; Grg-1; Grg1; Tle1; Tle4l", "protein_names_uniprotkb": "Transducin-like enhancer protein 1; Grg-1; Groucho-related protein 1", "protein_names_refseq": "groucho-related protein 1; transducin-like enhancer of split 1, homolog of Drosophila E(spl); transducin-like enhancer of split 4 (homolog of Drosophila E(spl)) - like; transducin-like enhancer protein 1 isoform c; transducin-like enhancer protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:21885); (R-MMU-201722); (R-MMU-3769402); (R-MMU-4641265); (R-MMU-9764725)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "11266540;11756536;12359720;16314515;18254933;21183079;21429299;21750661;22872234;23990468;36852467;8713081;8892234", "class_list": "", "function": "Grg1-S may operate in conjunction with beta-catenin and Tcf factors to regulate vertebrate gut epithelial cell differentiation, [RefSeq, PubMed]; Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (PubMed:16314515). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5SQA8", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q62440-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K007-1", "uniprot_id": "SULF1_MOUSE", "mass": 100923.0, "length": 870, "protein_name": "Extracellular sulfatase Sulf-1", "gene_name": "Sulf1", "organism": "Mouse", "refseq_name": "extracellular sulfatase Sulf-1 precursor", "refseq_ac": "NP_001185494", "gene_names_uniprotkb": "Sulf1; Kiaa1077", "gene_names_refseq": "MSulf-1; Sulf1; mKIAA1077", "protein_names_uniprotkb": "Extracellular sulfatase Sulf-1; 3.1.6.14; 3.1.6.1; Arylsulfatase; N-acetylglucosamine-6-sulfatase; mSulf-1", "protein_names_refseq": "N-acetylglucosamine-6-sulfatase; arylsulfatase; extracellular sulfatase SULF-1; extracellular sulfatase Sulf-1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:240725)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12368295;21750661;25428506;30084848;30779550;34428180", "class_list": "glycogene", "function": "Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (By similarity). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (By similarity). Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (By similarity)., [UniProtKB, UniProtKB]; Sulfs are extracellular endosulfatases with strong potential for modulating the interactions of heparan sulfate proteoglycans in the extracellular microenvironment, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 39, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPZ0;Q8BLJ0;Q8C1D3", "ec_number_list": "3.1.6.1;3.1.6.15;3.1.6.14;3.1.6.18", "go_molecular_function": "GO:0008449 N-acetylglucosamine-6-sulfatase activity;GO:0005509 calcium ion binding;GO:0004065 arylsulfatase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft", "go_biological_process": "GO:0030201 heparan sulfate proteoglycan metabolic process;GO:0060384 innervation;GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0014846 esophagus smooth muscle contraction;GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8K007-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJ83-1", "uniprot_id": "TM2D3_MOUSE", "mass": 28880.0, "length": 261, "protein_name": "TM2 domain-containing protein 3", "gene_name": "Tm2d3", "organism": "Mouse", "refseq_name": "TM2 domain-containing protein 3 isoform 1", "refseq_ac": "NP_081071", "gene_names_uniprotkb": "Tm2d3", "gene_names_refseq": "1110025I09Rik; 5930422O05Rik; Blp2; Tm2d3", "protein_names_uniprotkb": "TM2 domain-containing protein 3", "protein_names_refseq": "BBP-like protein 2; TM2 domain-containing protein 3 isoform 1; TM2 domain-containing protein 3", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:68634)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;31219806;38016980", "class_list": "", "function": "Positive regulator of Notch signaling, required for activation of NOTCH1 intracellular processing and NOTCH1 localization to the cell membrane., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 11, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9D156", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0046331 lateral inhibition;GO:2000010 positive regulation of protein localization to cell surface;GO:0045747 positive regulation of Notch signaling pathway;GO:0035334 Notch receptor processing, ligand-independent", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8BJ83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CEF9-1", "uniprot_id": "T132C_MOUSE", "mass": 121378.0, "length": 1099, "protein_name": "Transmembrane protein 132C", "gene_name": "Tmem132c", "organism": "Mouse", "refseq_name": "transmembrane protein 132C precursor", "refseq_ac": "NP_780641", "gene_names_uniprotkb": "Tmem132c", "gene_names_refseq": "2810482M11Rik; 3230401P16; 4632425D07Rik; Tmem132c", "protein_names_uniprotkb": "Transmembrane protein 132C", "protein_names_refseq": "transmembrane protein 132C precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:208213)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;33300544;34428180;35820727", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8BS69", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0010923 negative regulation of phosphatase activity", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8CEF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ES03-1", "uniprot_id": "TBX20_MOUSE", "mass": 49096.0, "length": 445, "protein_name": "T-box transcription factor TBX20", "gene_name": "Tbx20", "organism": "Mouse", "refseq_name": "T-box transcription factor TBX20 isoform c", "refseq_ac": "NP_001192014", "gene_names_uniprotkb": "Tbx20; Tbx12", "gene_names_refseq": "9430010M06Rik; Tbx12; Tbx20", "protein_names_uniprotkb": "T-box transcription factor TBX20; T-box protein 20", "protein_names_refseq": "T-box protein 20; T-box transcription factor TBX20 isoform c; T-box transcription factor TBX20", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); atrial heart septal defect 4 (Disease Ontology:DOID:0110109); dilated cardiomyopathy (Disease Ontology:DOID:12930); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (mmu:57246)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10936053;10940636;11118890;15901664;21750661;22328084;25428506;36852467", "class_list": "", "function": "Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9EPZ5;Q9ESX1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0001708 cell fate specification;GO:0036302 atrioventricular canal development;GO:0003171 atrioventricular valve development;GO:0060577 pulmonary vein morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9ES03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSD4-1", "uniprot_id": "TBATA_MOUSE", "mass": 43842.0, "length": 393, "protein_name": "Protein TBATA", "gene_name": "Tbata", "organism": "Mouse", "refseq_name": "protein TBATA isoform 5", "refseq_ac": "NP_001017407", "gene_names_uniprotkb": "Tbata; Spatial", "gene_names_refseq": "1700021K02Rik; Spatial; Tbata; Titest", "protein_names_uniprotkb": "Protein TBATA; Protein SPATIAL; Stromal protein associated with thymii and lymph node; Thymus, brain and testes-associated protein", "protein_names_refseq": "protein SPATIAL; protein TBATA isoform 5; protein TBATA; stromal protein associated with thymii and lymph nodes; thymus and testis specific nuclear protein; thymus, brain and testes-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:65971)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11196687;12711538;15236666;17196196;17961552;19918778;20937703;21750661;24361585", "class_list": "", "function": "A new short thymus isoform, Spatial-beta, differs from other isoforms by an additional alternative exon of 69 bases. This new exon encodes an interesting proline-rich signature that could confer to the 34 kDa Spatial-beta protein a particular function. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that Spatial expression is independent of thymocyte-derived signals during thymus organogenesis., [RefSeq, PubMed]; Isoform 1 and isoform 2 may play a role in spermatid differentiation. Isoform 1 and isoform 2 regulate thymus function by modulating stromal cell proliferation via interference with the NEDD8 pathway., [UniProtKB, PubMed, PubMed]; Provides evidence for non-AUG translation initiation site, [RefSeq, PubMed]; Spatial, through its transport by Kif17, is crucial for neuronal polarization., [RefSeq, PubMed]; Tbata modulates thymus function by regulating stromal cell proliferation via the Nedd8 pathway., [RefSeq, PubMed]; These findings suggest that Spatial may play a role in neuronal morphogenesis and synaptic plasticity through its interaction with the kinesin motor KIF17 in dendrites., [RefSeq, PubMed]; This gene encodes a putative transcription factor that is highly expressed in thymic cortical stromal cells, and may be involved in T-cell development. Its expression is developmentally regulated in the testis, where it is restricted to the haploid round spermatids during spermatogenesis, and thus this gene may also have a role in the control of male germ cell development. Alternative splicing of this gene results in two sets of transcript variants: the variants containing 5 additional exons at the 3' end encode long isoforms that are highly expressed in the testis, while the variants lacking the 3' end exons encode short isoforms that are highly expressed in the thymus. Most of the transcripts encoding the short isoforms have been shown to initiate translation from non-AUG (CUG) start sites. [provided by RefSeq, Jul 2008]., [RefSeq]; Together, these findings imply a function of Spatial in spermatid differentiation as a new cargo of kinesin KIF17b, in a microtubule-dependent mechanism specific to the manchette and the principal piece of the sperm tail., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2ZA64;Q6XBG6;Q6XBG7;Q6XBG8;Q7TSD5;Q8BYU0;Q9EQE4;Q9EQE5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0048515 spermatid differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TSD4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C581-1", "uniprot_id": "TMM91_MOUSE", "mass": 18085.0, "length": 172, "protein_name": "Transmembrane protein 91", "gene_name": "Tmem91", "organism": "Mouse", "refseq_name": "transmembrane protein 91 isoform 2", "refseq_ac": "NP_001277426", "gene_names_uniprotkb": "Tmem91; SynDIG3", "gene_names_refseq": "A830041P22Rik; DSPC3; SynDIG3; Tmem91", "protein_names_uniprotkb": "Transmembrane protein 91; DSPC3; Dispanin subfamily C member 3; Synapse differentiation-induced protein 3", "protein_names_refseq": "dispanin subfamily C member 3; synapse differentiation-induced protein 3; transmembrane protein 91 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:320208)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;22363774", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C581-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ER04-1", "uniprot_id": "TMPS5_MOUSE", "mass": 49644.0, "length": 455, "protein_name": "Transmembrane protease serine 5", "gene_name": "Tmprss5", "organism": "Mouse", "refseq_name": "transmembrane protease serine 5 isoform 2", "refseq_ac": "NP_109634", "gene_names_uniprotkb": "Tmprss5", "gene_names_refseq": "Tmprss5; spinesin", "protein_names_uniprotkb": "Transmembrane protease serine 5; 3.4.21.-; Spinesin", "protein_names_refseq": "transmembrane protease serine 5 isoform 2; transmembrane protease serine 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:80893)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;15465023;17918741;21750661", "class_list": "", "function": "Data report a newly isolated serine protease from mouse CNS, homologous to human spinesin type II transmembrane serine protease 5 and present as a full-length protein as well as type 1, 2, and 3 variants., [RefSeq, PubMed]; May play a role in hearing., [UniProtKB, UniProtKB, UniProtKB]; Mouse spinesin is involved in function of astrocytes in spinal cord and there may be astrocyte-specific regulation of its gene expression., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9Q2A5;Q9ER02;Q9ER03", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ER04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66JT5-1", "uniprot_id": "TPGS2_MOUSE", "mass": 33184.0, "length": 296, "protein_name": "Tubulin polyglutamylase complex subunit 2", "gene_name": "Tpgs2", "organism": "Mouse", "refseq_name": "tubulin polyglutamylase complex subunit 2 isoform a", "refseq_ac": "NP_001004361", "gene_names_uniprotkb": "Tpgs2; 5730494M16Rik", "gene_names_refseq": "5730437P09Rik; 5730494M16Rik; Pgs2; Tpgs2", "protein_names_uniprotkb": "Tubulin polyglutamylase complex subunit 2; PGs2", "protein_names_refseq": "tubulin polyglutamylase complex subunit 2 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:66648)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15890843;21750661;30084848", "class_list": "", "function": "Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAK1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0034451 centriolar satellite", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0000226 microtubule cytoskeleton organization;GO:0061523 cilium disassembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q66JT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXY1-1", "uniprot_id": "TBC31_MOUSE", "mass": 115838.0, "length": 996, "protein_name": "TBC1 domain family member 31", "gene_name": "Tbc1d31", "organism": "Mouse", "refseq_name": "TBC1 domain family member 31 isoform 1", "refseq_ac": "NP_001074865", "gene_names_uniprotkb": "Tbc1d31; Wdr67", "gene_names_refseq": "4B3; D330013L20Rik; Gm85; Tbc1d31; Wdr67", "protein_names_uniprotkb": "TBC1 domain family member 31; Protein 4-B-3; WD repeat-containing protein 67", "protein_names_refseq": "TBC1 domain family member 31 isoform 1; WD repeat domain 67; WD repeat-containing protein 67; protein 4-B-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:210544)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;21952136;22872234;25428506;27802388;30084848;31219806;34428180;36210013", "class_list": "", "function": "Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBW4;Q3U4F6;Q5KSA3;Q810J7;Q8C3Y2", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body", "go_biological_process": "GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6NXY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IMH0-1", "uniprot_id": "SMIP8_MOUSE", "mass": 24949.0, "length": 216, "protein_name": "Sperm microtubule inner protein 8", "gene_name": "Spmip8", "organism": "Mouse", "refseq_name": "sperm microtubule inner protein 8 isoform 2", "refseq_ac": "NP_082808", "gene_names_uniprotkb": "Spmip8; Tepp", "gene_names_refseq": "1700055M20Rik; Spmip8; Tepp", "protein_names_uniprotkb": "Sperm microtubule inner protein 8; Testis, prostate and placenta-expressed protein", "protein_names_refseq": "sperm microtubule inner protein 8 isoform 2; testis, prostate and placenta expressed; testis, prostate and placenta-expressed protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:73407)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14652002;21750661;27357688;37295417", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme (PubMed:37295417). May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella (PubMed:37295417)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SXB6;Q9D9K7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6IMH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97473-1", "uniprot_id": "TRBP2_MOUSE", "mass": 38842.0, "length": 365, "protein_name": "RISC-loading complex subunit TARBP2", "gene_name": "Tarbp2", "organism": "Mouse", "refseq_name": "RISC-loading complex subunit TARBP2 isoform 1", "refseq_ac": "NP_033345", "gene_names_uniprotkb": "Tarbp2; Prbp; TARBP2", "gene_names_refseq": "Prbp; TRBP; Tarbp2", "protein_names_uniprotkb": "RISC-loading complex subunit TARBP2; PRM-1 RNA-binding protein; Protamine-1 RNA-binding protein; TAR RNA-binding protein 2", "protein_names_refseq": "PRM-1 RNA-binding protein; RISC-loading complex subunit TARBP2 isoform 1; RISC-loading complex subunit TARBP2; TAR (HIV) RNA binding protein 2; TAR RNA-binding protein 2; protamine-1 RNA-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:21357); (R-MMU-203927); (R-MMU-426486); (R-MMU-9833482)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "16142218;17452327;21750661;23063653;27159388;28174252;29467169;31219806;33459340;8649414", "class_list": "", "function": "Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling., [RefSeq, PubMed]; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity). Binds in vitro to the PRM1 3'-UTR (PubMed:8649414). Seems to act as a repressor of translation (PubMed:8649414). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (PubMed:23063653). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (By similarity)., [UniProtKB, HAMAP, PubMed, PubMed, UniProtKB, UniProtKB]; Study demonstrated that Trbp participates in the regulation of muscle differentiation and regeneration Publication Status: Online-Only, [RefSeq, PubMed]; TARBP2, but not PRKRA, functions in miRNA biogenesis of a subclass of miRNAs, and suggesting that functional redundancy between TARBP2 and PRKRA does not involve miRNA biogenesis., [RefSeq, PubMed]; TRBP is a novel transcriptional coactivator of the Notch signaling pathway, playing an important role in neural stem cell regulation during mammalian brain development, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99M41", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0003725 double-stranded RNA binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0050689 negative regulation of defense response to virus by host;GO:0070922 RISC complex assembly;GO:0007286 spermatid development;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97473-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERA0-1", "uniprot_id": "TFCP2_MOUSE", "mass": 57031.0, "length": 502, "protein_name": "Alpha-globin transcription factor CP2", "gene_name": "Tfcp2", "organism": "Mouse", "refseq_name": "alpha-globin transcription factor CP2 isoform 2", "refseq_ac": "NP_001276532", "gene_names_uniprotkb": "Tfcp2; Tcfcp2", "gene_names_refseq": "CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d; LBP1; LSF; Tcfcp2; Tfcp2; UBP-1", "protein_names_uniprotkb": "Alpha-globin transcription factor CP2", "protein_names_refseq": "alpha-globin transcription factor CP2 isoform 2; alpha-globin transcription factor CP2", "tax_id": 10090, "disease": "", "pathway": " (mmu:21422)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15988015;1732747;19237534;21750661;27612612;28182010;29547954;35421367", "class_list": "", "function": "Binds a variety of cellular promoters including fibrinogen, alpha-globin promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter (By similarity)., [UniProtKB]; Mbd2-CP2c functional loop drives adult-type globin gene expression and erythroid differentiation of erythroid cells., [RefSeq, PubMed]; TFCP2, a binding protein of ATF3, promotes the progression of glioma by activating the synthesis of serine., [RefSeq, PubMed]; That yin yang 1 strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis, [RefSeq, PubMed]; The transcription factor CP2 upregulated miR-144 expression, which partially contributed to the suppression of COX-2 in mGCs. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGJ4;Q8VC13", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0042789 mRNA transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ERA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TN83-1", "uniprot_id": "SYT16_MOUSE", "mass": 71255.0, "length": 639, "protein_name": "Synaptotagmin-16", "gene_name": "Syt16", "organism": "Mouse", "refseq_name": "synaptotagmin-16 isoform 3", "refseq_ac": "NP_766392", "gene_names_uniprotkb": "Syt16; Strep14; Syt14l; Syt14r", "gene_names_refseq": "Strep14; Syt14l; Syt16; syt14r", "protein_names_uniprotkb": "Synaptotagmin-16; Synaptotagmin 14-like protein; Synaptotagmin XIV-related protein", "protein_names_refseq": "synaptotagmin 14-like protein; synaptotagmin XIV-related protein; synaptotagmin-16 isoform 3; synaptotagmin-16", "tax_id": 10090, "disease": "", "pathway": " (mmu:238266)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12801916;21750661", "class_list": "", "function": "May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVM4;Q6PGM6;Q8BJ41", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TN83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56581-1", "uniprot_id": "TDG_MOUSE", "mass": 46879.0, "length": 421, "protein_name": "G/T mismatch-specific thymine DNA glycosylase", "gene_name": "Tdg", "organism": "Mouse", "refseq_name": "G/T mismatch-specific thymine DNA glycosylase isoform 1", "refseq_ac": "NP_035691", "gene_names_uniprotkb": "Tdg", "gene_names_refseq": "E130317C12Rik; JZA-3; Jza1; Tdg", "protein_names_uniprotkb": "G/T mismatch-specific thymine DNA glycosylase; 3.2.2.29; C-JUN leucine zipper interactive protein JZA-3; Thymine-DNA glycosylase", "protein_names_refseq": "C-JUN leucine zipper interactive protein JZA-3; G/T mismatch-specific thymine DNA glycosylase isoform 1; g/T mismatch-specific thymine DNA glycosylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:21665); (R-MMU-110329); (R-MMU-110357); (R-MMU-3108214); (R-MMU-5221030)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "1631061;19966277;21278727;21722948;21750661;21817016;25428506;30084848;30779550;31219806;34158086;34428180;36764492;37506700;9694815", "class_list": "", "function": "DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine (PubMed:21817016). Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC (PubMed:21722948). Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine., [UniProtKB, PubMed, PubMed, PubMed]; Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells. Publication Status: Online-Only, [RefSeq, PubMed]; TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype., [RefSeq, PubMed]; Thymine DNA glycosylase regulates cell-cycle-driven p53 transcriptional control in pluripotent cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPW4;Q542A9;Q5U3M4;Q5U3M5;Q6PJW4;Q8BPK0", "ec_number_list": "3.1.11.2;3.1.21.-;3.2.2.29;2.3.2.-", "go_molecular_function": "GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity;GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016605 PML body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006284 base-excision repair;GO:0040029 epigenetic regulation of gene expression;GO:0045995 regulation of embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P56581-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVB2-1", "uniprot_id": "TLE2_MOUSE", "mass": 82623.0, "length": 767, "protein_name": "Transducin-like enhancer protein 2", "gene_name": "Tle2", "organism": "Mouse", "refseq_name": "transducin-like enhancer protein 2 isoform 1", "refseq_ac": "NP_062699", "gene_names_uniprotkb": "Tle2; Grg2", "gene_names_refseq": "Gm32024; Grg2; Tle2; mKIAA4188", "protein_names_uniprotkb": "Transducin-like enhancer protein 2", "protein_names_refseq": "groucho-related protein; transducin-like enhancer of split 2, homolog of Drosophila E(spl); transducin-like enhancer protein 2 isoform 1; transducin-like enhancer protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:21886); (R-MMU-201722); (R-MMU-3769402); (R-MMU-4641265)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11486032;18254933;21750661;23990468;32782141", "class_list": "", "function": "Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005925 focal adhesion;GO:0016604 nuclear body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0045892 negative regulation of DNA-templated transcription;GO:0016055 Wnt signaling pathway;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WVB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88856-1", "uniprot_id": "TPST2_MOUSE", "mass": 42067.0, "length": 376, "protein_name": "Protein-tyrosine sulfotransferase 2", "gene_name": "Tpst2", "organism": "Mouse", "refseq_name": "protein-tyrosine sulfotransferase 2", "refseq_ac": "NP_001313519", "gene_names_uniprotkb": "Tpst2; D5ucla3", "gene_names_refseq": "D5Ucla3; Tango13b; Tpst2; grm; grt", "protein_names_uniprotkb": "Protein-tyrosine sulfotransferase 2; 2.8.2.20; TPST-2; Tyrosylprotein sulfotransferase 2", "protein_names_refseq": "TPST-2; protein-tyrosine sulfotransferase 2; tyrosylprotein sulfotransferase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22022); (R-MMU-156584); (R-MMU-163841)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;19349973;21750661;25231844;34428180;37671153;9733778", "class_list": "glycogene", "function": "Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cerebral abnormalities in grt/grt Tpst2 gene defect mice are characterized by cortical hypoplasia at the frontooccipital axis with immature pyramidal neurons and insufficient development of callosal fibers, [RefSeq, PubMed]; TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CBA8", "ec_number_list": "2.8.2.20", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008476 protein-tyrosine sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0060468 prevention of polyspermy;GO:0006478 peptidyl-tyrosine sulfation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O88856-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBU0-1", "uniprot_id": "TM9S1_MOUSE", "mass": 68928.0, "length": 606, "protein_name": "Transmembrane 9 superfamily member 1", "gene_name": "Tm9sf1", "organism": "Mouse", "refseq_name": "transmembrane 9 superfamily member 1 precursor", "refseq_ac": "NP_083056", "gene_names_uniprotkb": "Tm9sf1", "gene_names_refseq": "1200014D02Rik; MP70; Tm9sf1", "protein_names_uniprotkb": "Transmembrane 9 superfamily member 1", "protein_names_refseq": "transmembrane 9 superfamily member 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:74140)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34428180;37828378", "class_list": "", "function": "Plays an essential role in autophagy., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7S4;Q8VD27;Q922J5;Q9ET29", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006914 autophagy;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DBU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3W5-1", "uniprot_id": "SEN15_MOUSE", "mass": 18530.0, "length": 168, "protein_name": "tRNA-splicing endonuclease subunit Sen15", "gene_name": "Tsen15", "organism": "Mouse", "refseq_name": "tRNA-splicing endonuclease subunit Sen15", "refseq_ac": "NP_079953", "gene_names_uniprotkb": "Tsen15; Sen15", "gene_names_refseq": "5730449L18Rik; Sen15; Tsen15", "protein_names_uniprotkb": "tRNA-splicing endonuclease subunit Sen15; tRNA-intron endonuclease Sen15", "protein_names_refseq": "tRNA splicing endonuclease 15 homolog; tRNA-intron endonuclease Sen15; tRNA-splicing endonuclease subunit Sen15", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 2F (Disease Ontology:DOID:0112329)", "pathway": " (mmu:66637)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6H601;Q9CQW8;Q9CYI5", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0000214 tRNA-intron endonuclease complex;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0000379 tRNA-type intron splice site recognition and cleavage;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R3W5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGN8-1", "uniprot_id": "SYNPR_MOUSE", "mass": 29228.0, "length": 265, "protein_name": "Synaptoporin", "gene_name": "Synpr", "organism": "Mouse", "refseq_name": "synaptoporin isoform 2 precursor", "refseq_ac": "NP_001156504", "gene_names_uniprotkb": "Synpr", "gene_names_refseq": "1500003F20Rik; SPO; Synpr", "protein_names_uniprotkb": "Synaptoporin", "protein_names_refseq": "synaptoporin isoform 2 precursor; synaptorin", "tax_id": 10090, "disease": "", "pathway": " (mmu:72003)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5J4;Q9DB89", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0098686 hippocampal mossy fiber to CA3 synapse;GO:0016020 membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BGN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYH7-1", "uniprot_id": "TBC17_MOUSE", "mass": 72860.0, "length": 645, "protein_name": "TBC1 domain family member 17", "gene_name": "Tbc1d17", "organism": "Mouse", "refseq_name": "TBC1 domain family member 17 isoform 1", "refseq_ac": "NP_001036120", "gene_names_uniprotkb": "Tbc1d17", "gene_names_refseq": "Tbc1d17", "protein_names_uniprotkb": "TBC1 domain family member 17", "protein_names_refseq": "TBC1 domain family member 17 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:233204); (R-MMU-8854214)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;34428180;35820727;37828378", "class_list": "", "function": "Probable GTPase-activating protein that inhibits RAB8A/B function. Reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC) and inhibits Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TfR). Involved in regulation of autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCA5", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0005776 autophagosome", "go_biological_process": "GO:0015031 protein transport;GO:0006914 autophagy;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BYH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSH8-1", "uniprot_id": "TMM94_MOUSE", "mass": 151796.0, "length": 1360, "protein_name": "Transmembrane protein 94", "gene_name": "Tmem94", "organism": "Mouse", "refseq_name": "transmembrane protein 94", "refseq_ac": "NP_082290", "gene_names_uniprotkb": "Tmem94; 2310067B10Rik; Erma; Kiaa0195", "gene_names_refseq": "2310067B10Rik; ERMA; Kiaa0195; Tmem94; mKIAA0195", "protein_names_uniprotkb": "Transmembrane protein 94; Endoplasmic reticulum magnesium ATPase", "protein_names_refseq": "endoplasmic reticulum magnesium ATPase; endoplasmic reticulum magnesium-transporting P-type ATPase; transmembrane protein 94", "tax_id": 10090, "disease": "", "pathway": " (mmu:71947)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;30084848;30526868;31219806;34428180;38513662;38879951;40885482", "class_list": "", "function": "Could function in the uptake of Mg(2+) from the cytosol into the endoplasmic reticulum and regulate intracellular Mg(2+) homeostasis., [UniProtKB, PubMed]; ERMA (TMEM94) is a P-type ATPase transporter for Mg[2+] uptake in the endoplasmic reticulum., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B1AT99;Q80U66;Q8BL05;Q8K0Q0;Q91VY1", "ec_number_list": "", "go_molecular_function": "GO:0015444 P-type magnesium transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1990403 embryonic brain development;GO:0010961 intracellular magnesium ion homeostasis;GO:0035050 embryonic heart tube development;GO:0160176 magnesium ion transport from cytosol to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q7TSH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG19-1", "uniprot_id": "TMTC4_MOUSE", "mass": 82963.0, "length": 741, "protein_name": "Protein O-mannosyl-transferase TMTC4", "gene_name": "Tmtc4", "organism": "Mouse", "refseq_name": "protein O-mannosyl-transferase TMTC4", "refseq_ac": "NP_082927", "gene_names_uniprotkb": "Tmtc4", "gene_names_refseq": "4930403J22Rik; 5730419O14Rik; Tmtc4", "protein_names_uniprotkb": "Protein O-mannosyl-transferase TMTC4; 2.4.1.109; Transmembrane O-mannosyltransferase targeting cadherins 4; Transmembrane and tetratricopeptide repeat-containing 4", "protein_names_refseq": "protein O-mannosyl-transferase TMTC4; transmembrane O-mannosyltransferase targeting cadherins 4; transmembrane and TPR repeat-containing protein 4", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565)", "pathway": " (mmu:70551)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30188326;30899004;34428180", "class_list": "", "function": "Mice with homozygous inactivation of both Tmtc4 and Chop had less hearing loss than knockout of Tmtc4 alone. This study implicated a novel mechanism for hearing impairment, highlighting a potential treatment approach for a broad range of human hearing loss disorders., [RefSeq, PubMed]; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BT03;Q8C4D2;Q8CAC3;Q8K0I2;Q9CS83;Q9D5P3", "ec_number_list": "2.4.1.109", "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0051117 ATPase binding;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0035269 protein O-linked glycosylation via mannose;GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration;GO:1905584 outer hair cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BG19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CD91-1", "uniprot_id": "SMOC2_MOUSE", "mass": 49891.0, "length": 447, "protein_name": "SPARC-related modular calcium-binding protein 2", "gene_name": "Smoc2", "organism": "Mouse", "refseq_name": "SPARC-related modular calcium-binding protein 2 precursor", "refseq_ac": "NP_071710", "gene_names_uniprotkb": "Smoc2", "gene_names_refseq": "1700056C05Rik; 5430426J21Rik; Smoc2l; Smoc2", "protein_names_uniprotkb": "SPARC-related modular calcium-binding protein 2; SMOC-2; Secreted modular calcium-binding protein 2", "protein_names_refseq": "SMOC-2; SPARC-related modular calcium-binding protein 2 precursor; SPARC-related modular calcium-binding protein 2; secreted modular calcium-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:64074)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12741954;16774925;18757743;21750661;26495903", "class_list": "", "function": "Can stimulate endothelial cell proliferation, migration, as well as angiogenesis (By similarity). Promotes matrix assembly and cell adhesiveness., [UniProtKB, PubMed]; SMOC-2 is a novel angiogenic factor that potentiates angiogenic effects of growth factors, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCM1;Q9D9K2;Q9ER95", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding;GO:0050840 extracellular matrix binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0071944 cell periphery;GO:0005604 basement membrane;GO:0005614 interstitial matrix", "go_biological_process": "GO:0035470 positive regulation of vascular wound healing;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0030198 extracellular matrix organization;GO:0045931 positive regulation of mitotic cell cycle;GO:0010595 positive regulation of endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CD91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11985-1", "uniprot_id": "DYLT2_MOUSE", "mass": 22379.0, "length": 191, "protein_name": "Dynein light chain Tctex-type protein 2", "gene_name": "Dynlt2a1; Dynlt2a2; Dynlt2a3; Dynlt2", "organism": "Mouse", "refseq_name": "t-complex-associated testis expressed 3-like isoform 1", "refseq_ac": "NP_001116839", "gene_names_uniprotkb": "Dynlt2a1; Dynlt2a2; Dynlt2a3; Dynlt2; Dynlt2a2; Tcte3; Tctex1d3; Tctex2; Tctex4", "gene_names_refseq": "100041639; Dynlt2a2; Dynlt2b; Dynlt2; Gm3448; LC2; TCTEX-2; TCTEX-4; Tcte-3; Tcte3; Tctex1d3; Tctex2; Tctex4", "protein_names_uniprotkb": "Dynein light chain Tctex-type protein 2; LC2; T-complex testis-specific protein 2; T-complex testis-specific protein 3; T-complex-associated testis-expressed protein 3; T-complex-associated testis-expressed protein 4; TCTEX-2; TCTEX-4; Tcte-3; Tctex1 domain-containing protein 3", "protein_names_refseq": "T-complex testis-specific protein 2; T-complex testis-specific protein 3; T-complex-associated testis-expressed protein 3; T-complex-associated testis-expressed protein 4; Tctex1 domain-containing protein 3; dynein light chain Tctex-type 2; t-complex-associated testis expressed 3-like isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041586); (mmu:100041639); (mmu:21647); (R-MMU-5620924)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11278908;12849985;1718647;21750661;3653077;38236177;7601308", "class_list": "", "function": "Component of dynein, a family of motor proteins essential for movement along microtubules (PubMed:11278908). Required for structural and functional integrity of cilia (By similarity). Candidate for involvement in male sterility (By similarity)., [UniProtKB, PubMed, UniProtKB]; This gene is one of three genes with a very high degree of similarity to each other within a 77 kb genomic span on Chromosome 17 A2. This gene lies between the other two gene copies. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P51806;Q66L72;Q7TN76;Q9D9X4", "ec_number_list": "", "go_molecular_function": "GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0016020 membrane;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P11985-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UUG6-1", "uniprot_id": "TBC24_MOUSE", "mass": 63236.0, "length": 561, "protein_name": "TBC1 domain family member 24", "gene_name": "Tbc1d24", "organism": "Mouse", "refseq_name": "TBC1 domain family member 24 isoform a", "refseq_ac": "NP_001157319", "gene_names_uniprotkb": "Tbc1d24; Kiaa1171", "gene_names_refseq": "9630033P11; C530046L02Rik; Tbc1d24; mKIAA1171", "protein_names_uniprotkb": "TBC1 domain family member 24", "protein_names_refseq": "TBC1 domain family member 24 isoform a", "tax_id": 10090, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); developmental and epileptic encephalopathy 16 (Disease Ontology:DOID:0080449); autosomal recessive nonsyndromic deafness 86 (Disease Ontology:DOID:0110532); autosomal dominant nonsyndromic deafness 65 (Disease Ontology:DOID:0110586); DOORS syndrome (Disease Ontology:DOID:0111627); Rolandic epilepsy-paroxysmal exercise-induced dystonia-writer's cramp syndrome (Disease Ontology:DOID:0111645); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:224617); (R-MMU-8854214)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "20727515;20797691;21183079;21750661;24387994;26668325;30335140;30602030;31219806;32004315;34428180;34811399;38869222;39400345;39758816", "class_list": "", "function": "A pathogenic mutation was identified in TBC1D24., [RefSeq, PubMed]; May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515). Involved in neuronal projection development, probably through negative modulation of ARF6 function (PubMed:20727515, PubMed:30335140). Required for the maintenance of postsynaptic neuron dendritic spines in the adult by suppressing ARF6 activity (PubMed:32004315). Involved in the regulation of synaptic vesicle trafficking (PubMed:30335140). Promotes axonal outgrowth and membrane trafficking at the growth cone (By similarity). Positively regulates radial migration and morphological maturation of pyramidal neurons during cortical development by preventing ARF6 activation (By similarity). In one study, has been shown to inhibit the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (By similarity). In another study, has been shown to positively regulate V-ATPase assembly in neurons which promotes acidification of lysosomes and synaptic vesicles (PubMed:39758816). This supports neuronal autophagy and also regulates synaptic vesicle reacidification and the maintenance of the synaptic vesicle reserve pool (PubMed:39758816). Protects neuronal cells against oxidative stress (PubMed:26668325, PubMed:30335140). Involved in the maintainenance of endosomal-mediated vesicle recycling and sustained exocytosis of hair cell ribbon synapses (PubMed:39400345). Facilitates formation of tubular recycling endosomes which promotes recycling of clathrin-independent endocytosis cargo proteins back to the plasma membrane (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; TBC1D24 is likely to regulate vesicle trafficking in glia-like non-sensory epithelial cells of the cochlea. Publication Status: Online-Only, [RefSeq, PubMed]; Two compound heterozygous missense mutations (D147H and A509V) in TBC1D24, a gene of unknown function, are responsible for familial infantile myoclonic epilepsy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D6Q7;Q3TTZ8;Q3UH11;Q6ZPW4;Q8BH92;Q8BNF2;Q8C3C6;Q8C3W8", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0031594 neuromuscular junction;GO:0043195 terminal bouton", "go_biological_process": "GO:0016358 dendrite development;GO:0031175 neuron projection development;GO:2000463 positive regulation of excitatory postsynaptic potential;GO:0034599 cellular response to oxidative stress;GO:0050775 positive regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3UUG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2S7-1", "uniprot_id": "T22D3_MOUSE", "mass": 15177.0, "length": 137, "protein_name": "TSC22 domain family protein 3", "gene_name": "Tsc22d3", "organism": "Mouse", "refseq_name": "TSC22 domain family protein 3 isoform 1", "refseq_ac": "NP_001070832", "gene_names_uniprotkb": "Tsc22d3; Dsip1; Dsipi; Gilz", "gene_names_refseq": "DIP; Dsip1; Gilz; TSC-22R; Tilz3; Tsc22d3", "protein_names_uniprotkb": "TSC22 domain family protein 3; Glucocorticoid-induced leucine zipper protein; TSC22-related-inducible leucine zipper 3; Tilz3", "protein_names_refseq": "TSC22 domain family protein 3 isoform 1; TSC22 domain family protein 3; TSC22-related inducible leucine zipper 3; delta sleep inducing peptide, immunoreactor; long glucocorticoid-induced leucine zipper protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:14605); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11397794;11468175;11774584;12393603;15031210;17147695;20124407;21183079;21750661;25428506;26752201;34831376;37408237;9430225", "class_list": "", "function": "GILZ Modulates the Recruitment of Monocytes/Macrophages Endowed with a Resolving Phenotype and Favors Resolution of Escherichia coli Infection. Publication Status: Online-Only, [RefSeq, PubMed]; GILZ, a glucocorticoid hormone induced gene, modulates T lymphocytes activation and death through interaction with NF-kB., [RefSeq, PubMed]; Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG., [UniProtKB, PubMed]; Multi-Tissue Characterization of GILZ Expression in Dendritic Cell Subsets at Steady State and in Inflammatory Contexts. Publication Status: Online-Only, [RefSeq, PubMed]; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 (PubMed:26752201). In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (By similarity). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (By similarity). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (PubMed:11397794)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AVF3;C6EX03;Q3UNI6;Q8K160;Q9EQN0;Q9EQN1;Q9EQN2", "ec_number_list": "", "go_molecular_function": "GO:0043426 MRF binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006970 response to osmotic stress;GO:0070236 negative regulation of activation-induced cell death of T cells;GO:0048642 negative regulation of skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9Z2S7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60770-1", "uniprot_id": "STXB3_MOUSE", "mass": 67942.0, "length": 592, "protein_name": "Syntaxin-binding protein 3", "gene_name": "Stxbp3", "organism": "Mouse", "refseq_name": "syntaxin-binding protein 3", "refseq_ac": "NP_035634", "gene_names_uniprotkb": "Stxbp3; Stxbp3a; Unc18c", "gene_names_refseq": "Munc-18c; Stxbp3a; Stxbp3; Sxtbp3; Unc18-3", "protein_names_uniprotkb": "Syntaxin-binding protein 3; MUNC-18-3; Mammalian homolog of Unc-18c; Munc-18c; Protein unc-18 homolog 3; Protein unc-18 homolog C; Unc-18C; Unc18-3", "protein_names_refseq": "MUNC-18-3; mammalian homolog of Unc-18c; protein unc-18 homolog 3; protein unc-18 homolog C; syntaxin binding protein 3A; syntaxin-binding protein 3; unc-18 homolog 3; unc-18C", "tax_id": 10090, "disease": "", "pathway": " (mmu:20912); (R-MMU-114516)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12297296;12527361;17548353;18541526;21750661;29599294;32209659;34428180;7890715;8824310;9045631", "class_list": "", "function": "Cellular munc18c levels can modulate glucose transport rate and GLUT4 translocation in 3T3L1 cells., [RefSeq, PubMed]; MicroRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens., [RefSeq, PubMed]; Observed an almost complete absence of exocytosis in Munc18-2-deficient MCs but intact exocytosis in MCs lacking Munc18-1 or Munc18-3, [RefSeq, PubMed]; Our data suggest that the mechanism by which glucosamine inhibits insulin-stimulated GLUT4 translocation involves modification of Munc18c., [RefSeq, PubMed]; Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TE73;Q3U2S2;Q3U8D9;Q3UA91;Q3UUB0", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0019905 syntaxin binding;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030141 secretory granule;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043312 neutrophil degranulation;GO:0007420 brain development;GO:0045955 negative regulation of calcium ion-dependent exocytosis;GO:0032868 response to insulin", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q60770-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MB1-1", "uniprot_id": "TLR3_MOUSE", "mass": 103671.0, "length": 905, "protein_name": "Toll-like receptor 3", "gene_name": "Tlr3", "organism": "Mouse", "refseq_name": "toll-like receptor 3 precursor", "refseq_ac": "NP_569054", "gene_names_uniprotkb": "Tlr3", "gene_names_refseq": "Tlr3", "protein_names_uniprotkb": "Toll-like receptor 3", "protein_names_refseq": "toll-like receptor 3 precursor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); colitis (Disease Ontology:DOID:0060180); critical COVID-19 (Disease Ontology:DOID:0081012); severe COVID-19 (Disease Ontology:DOID:0081013); pre-eclampsia (Disease Ontology:DOID:10591); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); anogenital venereal wart (Disease Ontology:DOID:11168); Behcet's disease (Disease Ontology:DOID:13241); colon carcinoma (Disease Ontology:DOID:1520); alcohol use disorder (Disease Ontology:DOID:1574); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); asthma (Disease Ontology:DOID:2841); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); eye disease (Disease Ontology:DOID:5614); peripheral nervous system disease (Disease Ontology:DOID:574); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684); autoimmune thyroiditis (Disease Ontology:DOID:7188); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:142980)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11607032;11923871;14993594;17452530;18420935;20173027;21750661;25428506;25736436;26740625;30084848;31076723;31599954;33432245;34428180", "class_list": "", "function": "Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity)., [UniProtKB, PubMed]; Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 15, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 15, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 15, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9384, "biomarker_type": "", "glycan_count": 6, "disease_count": 25, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZM4", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0003725 double-stranded RNA binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0032727 positive regulation of interferon-alpha production;GO:0002730 regulation of dendritic cell cytokine production;GO:0034346 positive regulation of type III interferon production;GO:0001774 microglial cell activation", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q99MB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70362-1", "uniprot_id": "UFD1_MOUSE", "mass": 34481.0, "length": 307, "protein_name": "Ubiquitin recognition factor in ER-associated degradation protein 1", "gene_name": "Ufd1", "organism": "Mouse", "refseq_name": "ubiquitin recognition factor in ER-associated degradation protein 1", "refseq_ac": "NP_035802", "gene_names_uniprotkb": "Ufd1; Ufd1l", "gene_names_refseq": "Ufd1l; Ufd1", "protein_names_uniprotkb": "Ubiquitin recognition factor in ER-associated degradation protein 1; UB fusion protein 1; Ubiquitin fusion degradation protein 1 homolog", "protein_names_refseq": "UB fusion protein 1; ubiquitin fusion degradation 1 like; ubiquitin fusion degradation protein 1 homolog; ubiquitin recognition factor in ER-associated degradation protein 1", "tax_id": 10090, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); velocardiofacial syndrome (Disease Ontology:DOID:12583); neurodegenerative disease (Disease Ontology:DOID:1289); schizophrenia (Disease Ontology:DOID:5419); cleft palate (Disease Ontology:DOID:674)", "pathway": " (mmu:22230); (R-MMU-110320); (R-MMU-5689880); (R-MMU-8951664); (R-MMU-9755511)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "17242355;21183079;21750661;24160817;25428506;26112410;34428180;9063746", "class_list": "", "function": "Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The study revealed a regulatory role of the p97-Npl4-Ufd1 complex in regulating a partial degradation of the NF-kappaB subunit p100., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q923C4", "ec_number_list": "", "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0005102 signaling receptor binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0051117 ATPase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0036501 UFD1-NPL4 complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0071218 cellular response to misfolded protein;GO:0030970 retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P70362-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V0J1-1", "uniprot_id": "TM237_MOUSE", "mass": 47343.0, "length": 427, "protein_name": "Transmembrane protein 237", "gene_name": "Tmem237", "organism": "Mouse", "refseq_name": "transmembrane protein 237 isoform 1", "refseq_ac": "NP_001028621", "gene_names_uniprotkb": "Tmem237; Als2cr4", "gene_names_refseq": "Als2cr4; Gm972; Tmem237", "protein_names_uniprotkb": "Transmembrane protein 237; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog", "protein_names_refseq": "amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog; transmembrane protein 237 isoform 1", "tax_id": 10090, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); Joubert syndrome 14 (Disease Ontology:DOID:0110983)", "pathway": " (mmu:381259)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19144319;20375344;21750661;22152675;37041420", "class_list": "", "function": "Als2cr4 may be involved in membrane transport between the photoreceptor inner and outer segments and may be a key component in maintaining the structural integrity of the outer segment, [RefSeq, PubMed]; Component of the transition zone in primary cilia. Required for ciliogenesis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; HIF-1alpha-activated TMEM237 promotes hepatocellular carcinoma progression via the NPHP1/Pyk2/ERK pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RVK7;Q3TIS2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016607 nuclear speck;GO:0015630 microtubule cytoskeleton;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:0060271 cilium assembly;GO:0030111 regulation of Wnt signaling pathway;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3V0J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCQ6-1", "uniprot_id": "SMS1_MOUSE", "mass": 49317.0, "length": 419, "protein_name": "Phosphatidylcholine:ceramide cholinephosphotransferase 1", "gene_name": "Sgms1", "organism": "Mouse", "refseq_name": "phosphatidylcholine:ceramide cholinephosphotransferase 1", "refseq_ac": "NP_001161997", "gene_names_uniprotkb": "Sgms1; Tmem23", "gene_names_refseq": "9530058O11Rik; Mob; Sgms1; Sms1; Sor1; Tmem23", "protein_names_uniprotkb": "Phosphatidylcholine:ceramide cholinephosphotransferase 1; 2.7.8.27; Protein Mob; Sphingomyelin synthase 1; Transmembrane protein 23", "protein_names_refseq": "phosphatidylcholine:ceramide cholinephosphotransferase 1; protein Mob; transmembrane protein 23", "tax_id": 10090, "disease": "pulmonary edema (Disease Ontology:DOID:11396)", "pathway": " (mmu:208449); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14685263;16226406;16879426;21750661;22580896;22641779;25605874;27892528;39067415", "class_list": "glycogene", "function": "(Microbial infection) Contributes to the brain SM production for Japanese encephalitis virus attachment and infection., [UniProtKB, PubMed]; A new mutation of Sgms1 causes gradual hearing loss associated with a reduced endocochlear potential., [RefSeq, PubMed]; Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Converts the newly synthesized CER, that is transported from the endoplasmic reticulum to the trans-Golgi by the Cer transport protein (CERT), to SM. Can form a heteromeric complex with glucosylceramide synthase (GCS) increasing SMS activity and reducing glucosylceramide synthesis, a critical mechanism that controls the metabolic fate of CER in the Golgi (By similarity). Does not use free phosphorylcholine or CDP-choline as donor. Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to CER to form ceramide phosphoethanolamine (CPE) (PubMed:25605874). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:16879426, PubMed:22580896). Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 30, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIS8;Q5J3R0;Q8C464;Q8C583;Q8C652", "ec_number_list": "2.7.8.27;2.7.8.-;3.1.4.62", "go_molecular_function": "GO:0002950 ceramide phosphoethanolamine synthase activity;GO:0033188 sphingomyelin synthase activity;GO:0047493 ceramide cholinephosphotransferase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0010628 positive regulation of gene expression;GO:0046513 ceramide biosynthetic process;GO:0006915 apoptotic process;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8VCQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C2L6-1", "uniprot_id": "T161B_MOUSE", "mass": 55467.0, "length": 487, "protein_name": "Transmembrane protein 161B", "gene_name": "Tmem161b", "organism": "Mouse", "refseq_name": "transmembrane protein 161B isoform a", "refseq_ac": "NP_780396", "gene_names_uniprotkb": "Tmem161b", "gene_names_refseq": "2810446P07Rik; Tmem161b", "protein_names_uniprotkb": "Transmembrane protein 161B", "protein_names_refseq": "transmembrane protein 161B isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:72745)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;27802388;31219806;33597309;36669109;36669111;37222785", "class_list": "", "function": "Essential for maintaining normal cardiac rhythm in the developing heart and for neonatal survival (PubMed:33597309). Inhibits potassium and calcium currents in the cardiomyocytes, this assists in timely action potential repolarization and thereby maintains normal cardiac rhythm (PubMed:33597309)., [UniProtKB, PubMed]; Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart. Review article, [RefSeq, PubMed]; TMEM161B modulates radial glial scaffolding in neocortical development., [RefSeq, PubMed]; TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system., [RefSeq, PubMed]; The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BT72", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002027 regulation of heart rate;GO:0098901 regulation of cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C2L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UV71-1", "uniprot_id": "TMTC1_MOUSE", "mass": 105811.0, "length": 942, "protein_name": "Protein O-mannosyl-transferase TMTC1", "gene_name": "Tmtc1", "organism": "Mouse", "refseq_name": "protein O-mannosyl-transferase TMTC1 isoform 2", "refseq_ac": "NP_001334447", "gene_names_uniprotkb": "Tmtc1", "gene_names_refseq": "Arg99; Tmtc1", "protein_names_uniprotkb": "Protein O-mannosyl-transferase TMTC1; 2.4.1.109; Transmembrane O-mannosyltransferase targeting cadherins 1; Transmembrane and tetratricopeptide repeat-containing 1", "protein_names_refseq": "ARG99 homolog; protein O-mannosyl-transferase TMTC1 isoform 2; protein O-mannosyl-transferase TMTC1; transmembrane O-mannosyltransferase targeting cadherins 1; transmembrane and TPR repeat-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:387314)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30084848;39190102", "class_list": "", "function": "Notch transcriptional target tmtc1 maintains vascular homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QM13;Q8BQV5", "ec_number_list": "2.4.1.109", "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0006396 RNA processing;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UV71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U0M1-1", "uniprot_id": "TPPC9_MOUSE", "mass": 128232.0, "length": 1148, "protein_name": "Trafficking protein particle complex subunit 9", "gene_name": "Trappc9", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 9 isoform 3", "refseq_ac": "NP_001158113", "gene_names_uniprotkb": "Trappc9; Kiaa1882; Nibp", "gene_names_refseq": "1810044A24Rik; 2900005P22Rik; 4632408O18Rik; Ibp; Nibp; TRS130; Trappc9; mKIAA1882", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 9; NIK- and IKBKB-binding protein", "protein_names_refseq": "Ikk2 binding protein; NIK and IKK(beta) binding protein; NIK- and IKBKB-binding protein; trafficking protein particle complex subunit 9 isoform 3; trafficking protein particle complex subunit 9", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 13 (Disease Ontology:DOID:0081098); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:76510); (R-MMU-204005); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;15951441;16470246;21183079;21750661;22872234;25428506;27802388;30084848;31599954;34428180;37416774;38331351;40021952", "class_list": "", "function": "Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB, PubMed]; IBP, a novel regulator of Rho GTPases, is required for optimal T cell effector function, lymphocyte homeostasis, and the prevention of systemic autoimmunity., [RefSeq, PubMed]; Microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in Trappc9 KO mice., [RefSeq, PubMed]; NIBP is a NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3UU81;Q69Z79;Q6NS50;Q8CD01;Q8CFV8;Q9D8R6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005802 trans-Golgi network;GO:0030008 TRAPP complex;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0021987 cerebral cortex development;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0030182 neuron differentiation;GO:0006901 vesicle coating", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q3U0M1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U1C6-1", "uniprot_id": "TATD3_MOUSE", "mass": 32436.0, "length": 294, "protein_name": "Putative deoxyribonuclease TATDN3", "gene_name": "Tatdn3", "organism": "Mouse", "refseq_name": "putative deoxyribonuclease TATDN3 isoform 3", "refseq_ac": "NP_001156894", "gene_names_uniprotkb": "Tatdn3", "gene_names_refseq": "1500010M24Rik; Tatdn3", "protein_names_uniprotkb": "Putative deoxyribonuclease TATDN3; 3.1.21.-", "protein_names_refseq": "putative deoxyribonuclease TATDN3 isoform 3; putative deoxyribonuclease TATDN3", "tax_id": 10090, "disease": "", "pathway": " (mmu:68972)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Exhibits 3'-exonuclease and apurinic/apyrimidinic (AP) endonuclease activities (in vitro). Show preferential AP endonuclease activity on double-stranded DNA substrates and 3'- exonuclease activity on single-stranded DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8H6;Q9DB58", "ec_number_list": "", "go_molecular_function": "GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0046872 metal ion binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0016788 hydrolase activity, acting on ester bonds", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3U1C6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3LRV9-1", "uniprot_id": "TRML4_MOUSE", "mass": 29355.0, "length": 263, "protein_name": "Trem-like transcript 4 protein", "gene_name": "Treml4", "organism": "Mouse", "refseq_name": "trem-like transcript 4 protein isoform 1 precursor", "refseq_ac": "NP_001029094", "gene_names_uniprotkb": "Treml4; TLT4; Treml3", "gene_names_refseq": "5031403H21Rik; IDCP1; TLT-4; TLT4; Treml3; Treml4", "protein_names_uniprotkb": "Trem-like transcript 4 protein; TLT-4; Triggering receptor expressed on myeloid cells-like protein 3; Triggering receptor expressed on myeloid cells-like protein 4", "protein_names_refseq": "IG-like domain containing protein IDCP1c; trem-like transcript 4 protein isoform 1 precursor; trem-like transcript 4 protein; triggering receptor expressed on myeloid cells-like 3b; triggering receptor expressed on myeloid cells-like 3; triggering receptor expressed on myeloid cells-like protein 3; triggering receptor expressed on myeloid cells-like protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:224840); (R-MMU-198933)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19155473;21750661;22210914;25848864;32152506;32292401", "class_list": "", "function": "Positive regulator of TLR7 signaling that controls antiviral immunity and the development of autoimmunity, [RefSeq, PubMed]; Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages (PubMed:25848864). Regulates TLR7 signaling by controlling ligand-induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes (PubMed:25848864). Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production (PubMed:25848864). Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus (PubMed:25848864). Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs) (PubMed:19155473, PubMed:22210914, PubMed:25848864). Does not bind nucleic acids (PubMed:25848864). May participate in antigen presentation (PubMed:22210914)., [UniProtKB, PubMed, PubMed, PubMed]; TREML4 Promotes Inflammatory Programs in Human and Murine Macrophages and Alters Atherosclerosis Lesion Composition in the Apolipoprotein E Deficient Mouse. Publication Status: Online-Only, [RefSeq, PubMed]; Treml4 associates with adaptor molecule DNAX activation protein 12 kDa (DAP12) and serves as a marker for select groups of both dendritic cells and macrophages., [RefSeq, PubMed]; Treml4 participates in Ag presentation in vivo, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6XA78;E9Q825;Q3LRW0", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0002457 T cell antigen processing and presentation;GO:0006911 phagocytosis, engulfment;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0002230 positive regulation of defense response to virus by host", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3LRV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ASS6-1", "uniprot_id": "TITIN_MOUSE", "mass": 3906488.0, "length": 35213, "protein_name": "Titin", "gene_name": "Ttn", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ttn", "gene_names_refseq": "", "protein_names_uniprotkb": "Titin; 2.7.11.1; Connectin", "protein_names_refseq": "", "tax_id": 10090, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); congenital myopathy 5 (Disease Ontology:DOID:0081341); autosomal recessive limb-girdle muscular dystrophy type 2J (Disease Ontology:DOID:0110283); hypertrophic cardiomyopathy 9 (Disease Ontology:DOID:0110315); dilated cardiomyopathy 1G (Disease Ontology:DOID:0110430); tibial muscular dystrophy (Disease Ontology:DOID:0111078); myofibrillar myopathy 9 (Disease Ontology:DOID:0111188); dilated cardiomyopathy (Disease Ontology:DOID:12930); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": "", "pathway_count": 0, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;16702235;17242355;17261657;21183079;21750661;24129315;25428506;30059200;34203471;35820727;36084651;37453647;37507081;39927985;40021952;40885482;9440711", "class_list": "", "function": "Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 18, "predicted_n_glycosites": 0, "predicted_o_glycosites": 18, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 21, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 21, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 21, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 51, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 16, "disease_count": 10, "glyco_site_count": 46, "binding_glycan_count": 0, "secondary_ac_list": "A2ASS5;A2ASS7", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0002020 protease binding;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0000794 condensed nuclear chromosome;GO:0005865 striated muscle thin filament;GO:0030017 sarcomere;GO:0031674 I band", "go_biological_process": "GO:0035995 detection of muscle stretch;GO:1901897 regulation of relaxation of cardiac muscle;GO:0001701 in utero embryonic development;GO:0006936 muscle contraction;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 6.4, "record_id": "A2ASS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZR3-1", "uniprot_id": "TM40L_MOUSE", "mass": 34005.0, "length": 308, "protein_name": "Mitochondrial import receptor subunit TOM40B", "gene_name": "Tomm40l", "organism": "Mouse", "refseq_name": "mitochondrial import receptor subunit TOM40B", "refseq_ac": "NP_001032247", "gene_names_uniprotkb": "Tomm40l; Tomm40b", "gene_names_refseq": "Tomm40l", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM40B; Protein TOMM40-like", "protein_names_refseq": "mitochondrial import receptor subunit TOM40B; translocase of outer mitochondrial membrane 40 homolog-like", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:641376)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31599954", "class_list": "", "function": "Potential channel-forming protein implicated in import of protein precursors into mitochondria., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015288 porin activity;GO:0070678 preprotein binding;GO:0008320 protein transmembrane transporter activity;GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0046930 pore complex;GO:0032991 protein-containing complex;GO:0005742 mitochondrial outer membrane translocase complex;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CZR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q58Y74-1", "uniprot_id": "TRCG1_MOUSE", "mass": 88916.0, "length": 825, "protein_name": "Taste receptor cell protein 1", "gene_name": "Trcg1", "organism": "Mouse", "refseq_name": "taste receptor cell protein 1 precursor", "refseq_ac": "NP_001014420", "gene_names_uniprotkb": "Trcg1", "gene_names_refseq": "Trcg1", "protein_names_uniprotkb": "Taste receptor cell protein 1; Taste receptor protein 1", "protein_names_refseq": "taste receptor cell protein 1 precursor; taste receptor cell protein 1; taste receptor protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:541610)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15780750;21750661;35820727", "class_list": "", "function": "TRCG1 is expressed in a subset of taste receptor cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58Y73", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q58Y74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69ZZ6-1", "uniprot_id": "TMCC1_MOUSE", "mass": 71642.0, "length": 649, "protein_name": "Transmembrane and coiled-coil domains protein 1", "gene_name": "Tmcc1", "organism": "Mouse", "refseq_name": "transmembrane and coiled-coil domains protein 1 isoform 1", "refseq_ac": "NP_803131", "gene_names_uniprotkb": "Tmcc1; Kiaa0779", "gene_names_refseq": "3632431M01Rik; Tmcc1; mKIAA0779", "protein_names_uniprotkb": "Transmembrane and coiled-coil domains protein 1", "protein_names_refseq": "transmembrane and coiled-coil domains protein 1 isoform 1; transmembrane and coiled-coil domains protein 1", "tax_id": 10090, "disease": "alcohol-related neurodevelopmental disorder (Disease Ontology:DOID:0050667)", "pathway": " (mmu:330401)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15345747;17242355;21183079;21750661;25428506;30084848;30779550;34428180;37217942", "class_list": "", "function": "Circular RNA Tmcc1 improves astrocytic glutamate metabolism and spatial memory via NF-kappaB and CREB signaling in a bile duct ligation mouse model: transcriptional and cellular analyses. Publication Status: Online-Only, [RefSeq, PubMed]; Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission. Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEF4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0140284 endoplasmic reticulum-endosome membrane contact site", "go_biological_process": "GO:0016197 endosomal transport;GO:0007029 endoplasmic reticulum organization;GO:0090148 membrane fission;GO:0097750 endosome membrane tubulation;GO:0140285 endosome fission", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q69ZZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10711-1", "uniprot_id": "TCEA1_MOUSE", "mass": 33880.0, "length": 301, "protein_name": "Transcription elongation factor A protein 1", "gene_name": "Tcea1", "organism": "Mouse", "refseq_name": "transcription elongation factor A protein 1 isoform 3", "refseq_ac": "NP_001153222", "gene_names_uniprotkb": "Tcea1; Tceat", "gene_names_refseq": "S-II; Tcea1", "protein_names_uniprotkb": "Transcription elongation factor A protein 1; Transcription elongation factor S-II protein 1; Transcription elongation factor TFIIS.o", "protein_names_refseq": "transcription elongation factor A protein 1 isoform 3; transcription elongation factor A protein 1; transcription elongation factor S-II protein 1; transcription elongation factor TFIIS.o", "tax_id": 10090, "disease": "", "pathway": " (mmu:21399); (R-MMU-112382); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-75955)", "pathway_count": 8, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12761297;17242355;18630941;1917889;21183079;21750661;22872234;30009791;31361958;3346229;34428180;37828378", "class_list": "", "function": "Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus., [UniProtKB, UniProtKB, UniProtKB]; Tcea1 was identified as a gene which can influence the proliferative potential, survival and differentiation of myeloid cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P10712;P23713", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030218 erythrocyte differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P10711-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V009-1", "uniprot_id": "TMED1_MOUSE", "mass": 25263.0, "length": 227, "protein_name": "Transmembrane emp24 domain-containing protein 1", "gene_name": "Tmed1", "organism": "Mouse", "refseq_name": "transmembrane emp24 domain-containing protein 1 isoform 2", "refseq_ac": "NP_001311439", "gene_names_uniprotkb": "Tmed1; Il1rl1l", "gene_names_refseq": "Il1rl1l; Ly84l; St2l; Tmed1", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 1; Interleukin-1 receptor-like 1 ligand; Putative T1/ST2 receptor-binding protein; p24 family protein gamma-1; p24gamma1", "protein_names_refseq": "interleukin 1 receptor-like 1 ligand; lymphocyte antigen 84 ligand; p24 family protein gamma-1; p24gamma1; putative T1/ST2 receptor-binding protein; transmembrane emp24 domain containing 1; transmembrane emp24 domain-containing protein 1 isoform 2; transmembrane emp24 domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:17083)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;40997131;8621446", "class_list": "", "function": "Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1. Plays also a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUX8;Q61073;Q91YK3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3V009-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C2A2-1", "uniprot_id": "SEN54_MOUSE", "mass": 59083.0, "length": 525, "protein_name": "tRNA-splicing endonuclease subunit Sen54", "gene_name": "Tsen54", "organism": "Mouse", "refseq_name": "tRNA-splicing endonuclease subunit Sen54", "refseq_ac": "NP_083833", "gene_names_uniprotkb": "Tsen54; Sen54", "gene_names_refseq": "0610034P02Rik; Tsen54", "protein_names_uniprotkb": "tRNA-splicing endonuclease subunit Sen54; tRNA-intron endonuclease Sen54", "protein_names_refseq": "likely ortholog of H. sapiens SEN54L; tRNA splicing endonuclease 54 homolog; tRNA-intron endonuclease Sen54; tRNA-splicing endonuclease subunit Sen54", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 2A (Disease Ontology:DOID:0060267); pontocerebellar hypoplasia type 4 (Disease Ontology:DOID:0060273); pontocerebellar hypoplasia type 5 (Disease Ontology:DOID:0060274)", "pathway": " (mmu:76265)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ATA4;B1ATA5;Q9DCI5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0000214 tRNA-intron endonuclease complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0000379 tRNA-type intron splice site recognition and cleavage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C2A2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCA6-1", "uniprot_id": "T161A_MOUSE", "mass": 54015.0, "length": 480, "protein_name": "Transmembrane protein 161A", "gene_name": "Tmem161a", "organism": "Mouse", "refseq_name": "transmembrane protein 161A isoform 2", "refseq_ac": "NP_001280726", "gene_names_uniprotkb": "Tmem161a", "gene_names_refseq": "Tmem161a", "protein_names_uniprotkb": "Transmembrane protein 161A", "protein_names_refseq": "transmembrane protein 161A isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:234371)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806;37670024", "class_list": "", "function": "May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis (By similarity)., [UniProtKB]; Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNL7;Q8BSL1;Q8C2I8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0032526 response to retinoic acid;GO:0034599 cellular response to oxidative stress;GO:0045739 positive regulation of DNA repair;GO:0034644 cellular response to UV", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VCA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921U8-1", "uniprot_id": "SMTN_MOUSE", "mass": 100289.0, "length": 923, "protein_name": "Smoothelin", "gene_name": "Smtn", "organism": "Mouse", "refseq_name": "smoothelin isoform b", "refseq_ac": "NP_001152756", "gene_names_uniprotkb": "Smtn; Smsmo", "gene_names_refseq": "Smtn; smsmo", "protein_names_uniprotkb": "Smoothelin", "protein_names_refseq": "smoothelin A; smoothelin isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:29856)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10023782;10965129;16285958;18678771;21183079;21750661;25428506;30084848;32782141;34428180;34887587;35820727", "class_list": "", "function": "Smoothelin-A is essential for functional contractility of intestinal smooth muscle., [RefSeq, PubMed]; Smoothelins as key determinants of arterial smooth muscle contractility and cardiovascular performance, [RefSeq, PubMed]; Structural protein of the cytoskeleton., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCV2;Q6NSW1;Q8CD93;Q9JHG8;Q9JLU7;Q9R0D0;Q9R253;Q9Z0Q2", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0060452 positive regulation of cardiac muscle contraction;GO:0003085 negative regulation of systemic arterial blood pressure", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q921U8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2E2-1", "uniprot_id": "TOE1_MOUSE", "mass": 56871.0, "length": 511, "protein_name": "Target of EGR1 protein 1", "gene_name": "Toe1", "organism": "Mouse", "refseq_name": "target of EGR1 protein 1 isoform 1", "refseq_ac": "NP_080930", "gene_names_uniprotkb": "Toe1", "gene_names_refseq": "4930584N22Rik; 4933424D16Rik; Toe1", "protein_names_uniprotkb": "Target of EGR1 protein 1", "protein_names_refseq": "target of EGR1 protein 1 isoform 1; target of EGR1 protein 1", "tax_id": 10090, "disease": "pontocerebellar hypoplasia (Disease Ontology:DOID:0060264); pontocerebellar hypoplasia type 7 (Disease Ontology:DOID:0060276)", "pathway": " (mmu:68276)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17242355;21183079;21750661;28135057;34428180;36257135", "class_list": "", "function": "Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Knockdown of Toe1 causes developmental arrest during the morula-to-blastocyst transition in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFD8;Q8R5A4;Q9D412", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017069 snRNA binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0034472 snRNA 3'-end processing;GO:0016070 RNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D2E2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWT3-1", "uniprot_id": "SNX10_MOUSE", "mass": 23542.0, "length": 201, "protein_name": "Sorting nexin-10", "gene_name": "Snx10", "organism": "Mouse", "refseq_name": "sorting nexin-10 isoform a", "refseq_ac": "NP_001120820", "gene_names_uniprotkb": "Snx10", "gene_names_refseq": "2410004M09Rik; Snx10", "protein_names_uniprotkb": "Sorting nexin-10", "protein_names_refseq": "sorting nexin-10 isoform a", "tax_id": 10090, "disease": "autosomal recessive osteopetrosis 8 (Disease Ontology:DOID:0110940)", "pathway": " (mmu:71982)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;22174188;25811986;26141367;34428180;37647408;38271879;39095084", "class_list": "", "function": "Immunohistochemical analysis of embryo sections showed expression in long bone, calvariae, and developing teeth. The expression was limited to cells that also expressed TRAP, demonstrating osteoclastic localization., [RefSeq, PubMed]; Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells. Erratum:[Sci Adv. 2024 Apr 12;10(15):eadp3968. doi: 10.1126/sciadv.adp3968. PMID: 38608031], [RefSeq, PubMed]; Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption., [UniProtKB, PubMed]; SNX10 plays an important role in the bone destruction of collagen-induced arthritis mice., [RefSeq, PubMed]; SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation., [RefSeq, PubMed]; SNX10 regulates osteoclastogenic cell fusion and osteoclast size in mice., [RefSeq, PubMed]; Supplementation with calcium gluconate rescued mice from the rachitic phenotype and extended life span in global Snx10-deficient mice, suggesting that this may be a life-saving component of the clinical approach to Snx10-dependent human osteopetrosis Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1E0", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0005545 1-phosphatidylinositol binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:1990830 cellular response to leukemia inhibitory factor;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CWT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXN9-1", "uniprot_id": "GPHCC_MOUSE", "mass": 63380.0, "length": 555, "protein_name": "Golgi-pH regulating cation channel", "gene_name": "Tmem87a", "organism": "Mouse", "refseq_name": "transmembrane protein 87A isoform 2 precursor", "refseq_ac": "NP_001103966", "gene_names_uniprotkb": "Tmem87a; Golphcat", "gene_names_refseq": "A930025J12Rik; Tmem87a", "protein_names_uniprotkb": "Golgi-pH regulating cation channel; Elkin1; Transmembrane protein 87A", "protein_names_refseq": "elkin1; transmembrane protein 87A isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:211499); (R-MMU-8980692)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;19144319;19349973;21183079;21750661;25428506;30084848;30899004;32152506;32228863;34428180;35820727;38422143;38992057", "class_list": "", "function": "GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory. Publication Status: Online-Only, [RefSeq, PubMed]; Touch sensation requires the mechanically gated ion channel ELKIN1., [RefSeq, PubMed]; Voltage- and pH-dependent, inwardly rectifying cation channel that mediates ion flux across the Golgi membrane, supporting luminal acidification necessary for normal Golgi morphology and function (PubMed:38992057). Implicated in normal touch sensitivity through the generation of mechanically activated currents (PubMed:38422143). Could also be involved in cell mechanosensitivity regulating cell adhesion and migration (PubMed:32228863). May also be involved in retrograde transport from endosomes to the trans-Golgi network (TGN) (By similarity). Contributes to hippocampal spatial and contextual memory by maintaining Golgi function and structural integrity in hippocampal neurons (PubMed:38992057)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 8836, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTV9;Q8BU98;Q8R2P9;Q8R3S7", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0008308 voltage-gated monoatomic anion channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0050976 detection of mechanical stimulus involved in sensory perception of touch;GO:0071260 cellular response to mechanical stimulus;GO:0042147 retrograde transport, endosome to Golgi;GO:0051452 intracellular pH reduction", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8BXN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVB3-1", "uniprot_id": "TLE6_MOUSE", "mass": 65116.0, "length": 581, "protein_name": "Transducin-like enhancer protein 6", "gene_name": "Tle6", "organism": "Mouse", "refseq_name": "transducin-like enhancer protein 6 isoform 1", "refseq_ac": "NP_444484", "gene_names_uniprotkb": "Tle6; Grg6", "gene_names_refseq": "1810057E06Rik; Grg6; Tle6", "protein_names_uniprotkb": "Transducin-like enhancer protein 6; Groucho-related protein 6", "protein_names_refseq": "Groucho-related protein 6; transducin-like enhancer of split 6, homolog of Drosophila E(spl); transducin-like enhancer protein 6 isoform 1; transducin-like enhancer protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:114606)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11486032;16314515;18254933;18551179;18804437;21750661;23990468;25208553;28992324;31575650;32823735;34428180;35820727;37922900;38177687;39512902", "class_list": "", "function": "Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (PubMed:18804437, PubMed:25208553, PubMed:31575650, PubMed:37922900). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:31575650, PubMed:37922900). They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (PubMed:37922900). Also required for spermatogenesis: regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (PubMed:32823735, PubMed:39512902). Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (PubMed:16314515). Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (PubMed:23990468)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Expression of Tle6-like in colon cancer cells increased cell proliferation, colony-formation, cell migration, and xenograft tumorgenicity. Publication Status: Online-Only, [RefSeq, PubMed]; Grg6 is expressed in cortical neural progenitor cells, interacts with BF-1, and plays a role in in cortical neuron development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0140094 structural constituent of cytoplasmic lattice", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0051293 establishment of spindle localization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007015 actin filament organization;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9WVB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JM95-1", "uniprot_id": "SIA7F_MOUSE", "mass": 38167.0, "length": 333, "protein_name": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6", "gene_name": "St6galnac6", "organism": "Mouse", "refseq_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform 2 precursor", "refseq_ac": "NP_001020481", "gene_names_uniprotkb": "St6galnac6; Siat7f", "gene_names_refseq": "ST6GalNAcVI; Siat7f; St6galnac6", "protein_names_uniprotkb": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; 2.4.99.-; GalNAc alpha-2,6-sialyltransferase VI; SIAT7-F; ST6GalNAc VI; ST6GalNAcVI; Sialyltransferase 7F", "protein_names_refseq": "(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform 2 precursor; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; galNAc alpha-2,6-sialyltransferase VI; sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F", "tax_id": 10090, "disease": "", "pathway": " (mmu:50935); (R-MMU-4085001); (R-MMU-9037629); (R-MMU-9840309)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10702226;15858074;21750661;31219806", "class_list": "glycogene;glycosyltransferase", "function": "Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (PubMed:10702226). Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AK72;A2AK76;A2AK77;A2AK78;A2AK79;Q05CN1;Q8CDC3;Q9R0G9", "ec_number_list": "2.4.3.3;2.4.99.-;2.4.3.7", "go_molecular_function": "GO:0008373 sialyltransferase activity;GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006687 glycosphingolipid metabolic process;GO:0009311 oligosaccharide metabolic process;GO:0009100 glycoprotein metabolic process;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 550, "hit_score": 0.9, "record_id": "Q9JM95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U0J8-1", "uniprot_id": "TBD2B_MOUSE", "mass": 109950.0, "length": 965, "protein_name": "TBC1 domain family member 2B", "gene_name": "Tbc1d2b", "organism": "Mouse", "refseq_name": "TBC1 domain family member 2B isoform 1", "refseq_ac": "NP_919315", "gene_names_uniprotkb": "Tbc1d2b; Kiaa1055", "gene_names_refseq": "1810061M12Rik; Tbc1d2b; mKIAA1055", "protein_names_uniprotkb": "TBC1 domain family member 2B", "protein_names_refseq": "TBC1 domain family member 2B isoform 1", "tax_id": 10090, "disease": "neurodevelopmental disorder with seizures and gingival overgrowth (Disease Ontology:DOID:0070651)", "pathway": " (mmu:67016)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17242355;21183079;21750661;22872234;31219806;34428180;36210013", "class_list": "", "function": "GTPase-activating protein that plays a role in the early steps of endocytosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2VPQ4;Q6PHN8;Q6ZPZ5", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3U0J8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KJ5-1", "uniprot_id": "TCF19_MOUSE", "mass": 28068.0, "length": 263, "protein_name": "Transcription factor 19-like protein", "gene_name": "Tcf19", "organism": "Mouse", "refseq_name": "transcription factor 19-like protein", "refseq_ac": "NP_001157235", "gene_names_uniprotkb": "Tcf19; Sc1", "gene_names_refseq": "5730403J10Rik; Tcf19", "protein_names_uniprotkb": "Transcription factor 19-like protein; SC1 protein homolog; TCF-19", "protein_names_refseq": "SC1 protein homolog; TCF-19; transcription factor 19-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:106795)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Potential transcription factor that may play a role in the regulation of genes involved in cell cycle G1/S transition (By similarity). May bind to regulatory elements of genes, including the promoter of the transcription factor FOXO1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPA3;Q9CT93", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000082 G1/S transition of mitotic cell cycle;GO:0010468 regulation of gene expression;GO:0044342 type B pancreatic cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99KJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFE4-1", "uniprot_id": "SCYL2_MOUSE", "mass": 103317.0, "length": 930, "protein_name": "SCY1-like protein 2", "gene_name": "Scyl2", "organism": "Mouse", "refseq_name": "SCY1-like protein 2 isoform 1", "refseq_ac": "NP_932138", "gene_names_uniprotkb": "Scyl2; Cvak104; D10Ertd802e", "gene_names_refseq": "CVAK104; D10Ertd802e; Scyl2", "protein_names_uniprotkb": "SCY1-like protein 2; Coated vesicle-associated kinase of 104 kDa", "protein_names_refseq": "SCY1-like protein 2 isoform 1; SCY1-like protein 2; coated vesicle-associated kinase of 104 kDa", "tax_id": 10090, "disease": "arthrogryposis multiplex congenita-4 (Disease Ontology:DOID:0080980)", "pathway": " (mmu:213326)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "16914521;19144319;21183079;21750661;22517741;22645316;25428506;26203146;30059200;30084848;32782141;32848054;36852467;40885482;40997131", "class_list": "", "function": "Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system. A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (By similarity). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (PubMed:26203146)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Our findings clearly establish the SCY1-like family of protein pseudokinases as key regulators of neuronal function and survival., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 16, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 16, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 16, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q3UT57;Q3UWU9;Q8K0M4", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0010008 endosome membrane;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0031623 receptor internalization;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0007420 brain development;GO:0008333 endosome to lysosome transport;GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q8CFE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09925-1", "uniprot_id": "SURF1_MOUSE", "mass": 34798.0, "length": 306, "protein_name": "Surfeit locus protein 1", "gene_name": "Surf1", "organism": "Mouse", "refseq_name": "surfeit locus protein 1 isoform 2", "refseq_ac": "NP_001258653", "gene_names_uniprotkb": "Surf1; Surf-1", "gene_names_refseq": "0610010F23Rik; Surf-1; Surf1", "protein_names_uniprotkb": "Surfeit locus protein 1", "protein_names_refseq": "surfeit locus protein 1 isoform 2; surfeit locus protein 1", "tax_id": 10090, "disease": "mitochondrial complex IV deficiency nuclear type 1 (Disease Ontology:DOID:0070491); Charcot-Marie-Tooth disease type 4K (Disease Ontology:DOID:0110187); Leigh disease (Disease Ontology:DOID:3652)", "pathway": " (mmu:20930); (R-MMU-9864848)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17210671;21167962;21750661;23838831;24911525;26804654;27208630;29696791;3025660;31219806", "class_list": "", "function": "Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Fibroblasts from Surf1(-/-) mice are significantly more resistant to cell death caused by oxidative stress induced by paraquat or tert-Butyl hydroperoxide compared to cells from wild-type mice. In contrast, Surf1(-/-) fibroblasts show no difference in sensitivity to hydrogen peroxide stress, [RefSeq, PubMed]; Many proteins and metabolites are downregulated in Surf1(-/-) adipose tissue and reversed by Dietary restriction (DR), while in brain, most metabolites that changed were elevated in Surf1(-/-) mice., [RefSeq, PubMed]; Studies support the view that COX assembly is much more dependent on SURF1 in humans than in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99KB4;Q9DCU5", "ec_number_list": "", "go_molecular_function": "GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P09925-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DA77-1", "uniprot_id": "TEX29_MOUSE", "mass": 20894.0, "length": 186, "protein_name": "Testis-expressed protein 29", "gene_name": "Tex29", "organism": "Mouse", "refseq_name": "testis-expressed protein 29", "refseq_ac": "NP_083602", "gene_names_uniprotkb": "Tex29", "gene_names_refseq": "1700018L24Rik; Tex29", "protein_names_uniprotkb": "Testis-expressed protein 29", "protein_names_refseq": "testis-expressed protein 29; testis-expressed sequence 29 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:75528)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DA77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0P3-1", "uniprot_id": "MEAK7_MOUSE", "mass": 50845.0, "length": 455, "protein_name": "MTOR-associated protein MEAK7", "gene_name": "Meak7", "organism": "Mouse", "refseq_name": "MTOR-associated protein MEAK7", "refseq_ac": "NP_083159", "gene_names_uniprotkb": "Meak7; Kiaa1609; Tldc1", "gene_names_refseq": "4632415K11Rik; Kiaa1609; Meak7; Tldc1", "protein_names_uniprotkb": "MTOR-associated protein MEAK7; MEAK7; TBC/LysM-associated domain-containing protein 1; TLD domain-containing protein 1", "protein_names_refseq": "MTOR associated protein, eak-7 homolog; MTOR-associated protein MEAK7; TBC/LysM associated domain containing 1; TBC/LysM-associated domain-containing protein 1; TLD domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74347)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;26668325;34811399", "class_list": "", "function": "Activates an alternative mTOR signaling pathway through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration (By similarity). Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome (By similarity). Binds to the vacuolar-type ATPase (V-ATPase) complex, triggering a conformational change and is likely to regulate its activity (By similarity). No effect on V-ATPase activity was observed in vitro in one study although it was suggested that it may have inhibitory activity in vivo (By similarity). However, another study showed that it can promote V-ATPase activity (By similarity). Protects neuronal cells against oxidative stress (PubMed:26668325)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZF1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0042127 regulation of cell population proliferation;GO:0031667 response to nutrient levels;GO:0032868 response to insulin;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K0P3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97770-1", "uniprot_id": "THUM3_MOUSE", "mass": 56431.0, "length": 505, "protein_name": "tRNA (guanine(6)-N(2))-methyltransferase THUMP3", "gene_name": "Thumpd3", "organism": "Mouse", "refseq_name": "tRNA (guanine(6)-N(2))-methyltransferase THUMP3", "refseq_ac": "NP_032214", "gene_names_uniprotkb": "Thumpd3", "gene_names_refseq": "Gt(ROSA)26asSor; Gtrosa26as; Thumpd3", "protein_names_uniprotkb": "tRNA (guanine(6)-N(2))-methyltransferase THUMP3; 2.1.1.-; 2.1.1.256; GtROSA26asSor; THUMP domain-containing protein 3; tRNA(Trp) (guanine(7)-N(2))-methyltransferase THUMP3", "protein_names_refseq": "THUMP domain-containing protein 3; gene trap ROSA 26 antisense, Philippe Soriano; gtROSA26asSor; tRNA (guanine(6)-N(2))-methyltransferase THUMP3; tRNA (guanine(6)-N2)-methyltransferase THUMP3; tRNA(Trp) (guanine(7)-N(2))-methyltransferase THUMP3", "tax_id": 10090, "disease": "", "pathway": " (mmu:14911)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;34669960;37828378;9108056", "class_list": "", "function": "Catalytic subunit of the THUMPD3-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 6 (m2G6) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases. Also catalyzes the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 7 of tRNA(Trp)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99M45;Q9D3P0", "ec_number_list": "2.1.1.-;2.1.1.256", "go_molecular_function": "GO:0016423 tRNA (guanine) methyltransferase activity;GO:0000049 tRNA binding;GO:0160117 tRNA (guanine(6)-N2)-methyltransferase activity;GO:0160118 tRNA (guanine(7)-N2)-methyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043527 tRNA methyltransferase complex", "go_biological_process": "GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P97770-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXK4-1", "uniprot_id": "SWET1_MOUSE", "mass": 24649.0, "length": 221, "protein_name": "Sugar transporter SWEET1", "gene_name": "Slc50a1", "organism": "Mouse", "refseq_name": "sugar transporter SWEET1 isoform 1 precursor", "refseq_ac": "NP_033083", "gene_names_uniprotkb": "Slc50a1; Rag1ap1; Rga", "gene_names_refseq": "MmSWEET1; Rag1ap1; Rga; Slc50a1", "protein_names_uniprotkb": "Sugar transporter SWEET1; MmSWEET1; RAG1-activating protein 1; Solute carrier family 50 member 1", "protein_names_refseq": "RAG1-activating protein 1; probable sugar transporter RAG1AP1; recombination activating gene 1 activating protein 1; recombination activating gene 1 gene activation; solute carrier family 50 member 1; sugar transporter SWEET1 isoform 1 precursor; sugar transporter SWEET1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19729); (R-MMU-189200)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14991772;15547947;21107422;21750661;25428506;30084848;34428180;35820727;8630032", "class_list": "", "function": "Mediates sugar transport across membranes (By similarity). May regulate the expression of RAG1 a gene involved in V(D)J recombination., [UniProtKB, PubMed]; Mediates sugar transport across membranes., [UniProtKB, UniProtKB]; Novel protein-protein interaction with TRPV2, [RefSeq, PubMed]; RGA participates in the control of transient receptor potential cation channel, subfamily V, member 2 surface levels, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62275", "ec_number_list": "", "go_molecular_function": "GO:0051119 sugar transmembrane transporter activity;GO:0042947 glucoside transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0008643 carbohydrate transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CXK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BK08-1", "uniprot_id": "TMM11_MOUSE", "mass": 21312.0, "length": 190, "protein_name": "Transmembrane protein 11, mitochondrial", "gene_name": "Tmem11", "organism": "Mouse", "refseq_name": "transmembrane protein 11, mitochondrial isoform 1", "refseq_ac": "NP_775655", "gene_names_uniprotkb": "Tmem11", "gene_names_refseq": "5730466P16Rik; Tmem11", "protein_names_uniprotkb": "Transmembrane protein 11, mitochondrial; Protein PM1", "protein_names_refseq": "transmembrane protein 11, mitochondrial isoform 1; transmembrane protein 11, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:216821)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;37286744;37507081", "class_list": "", "function": "Plays a role in mitochondrial morphogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m[7]G methylation of ATF5 mRNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCT6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0007007 inner mitochondrial membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BK08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09117-1", "uniprot_id": "SYPL1_MOUSE", "mass": 28899.0, "length": 261, "protein_name": "Synaptophysin-like protein 1", "gene_name": "Sypl1", "organism": "Mouse", "refseq_name": "synaptophysin-like protein 1 isoform 1", "refseq_ac": "NP_038663", "gene_names_uniprotkb": "Sypl1; Pphn; Sypl", "gene_names_refseq": "D12Ertd446e; PanI; Pphn; Sypl1; Sypl", "protein_names_uniprotkb": "Synaptophysin-like protein 1; Pantophysin", "protein_names_refseq": "Pan I; pantophysin; synaptophysin-like protein 1 isoform 1; synaptophysin-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19027)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;19349973;19656770;21750661;25428506;25605945;29187734;30084848;30899004;31599954;34428180;37507081;37607933;39927985;40021952;40885482;8707851", "class_list": "", "function": "SYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQI8;Q8BQJ1;Q8C749", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0030141 secretory granule;GO:0042470 melanosome;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "O09117-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SV85-1", "uniprot_id": "SYNRG_MOUSE", "mass": 139616.0, "length": 1306, "protein_name": "Synergin gamma", "gene_name": "Synrg", "organism": "Mouse", "refseq_name": "synergin gamma isoform 7", "refseq_ac": "NP_919322", "gene_names_uniprotkb": "Synrg; Ap1gbp1; Syng", "gene_names_refseq": "Ap1gbp1; SYNG; Synrg", "protein_names_uniprotkb": "Synergin gamma; AP1 subunit gamma-binding protein 1; Gamma-synergin", "protein_names_refseq": "AP1 gamma subunit binding protein 1; synergin gamma isoform 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:217030)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;12808037;17242355;19144319;21183079;21750661;22645316;23806337;30084848;31219806;32782141;32848054;34428180;34678516;35822049;36210013;36852467;40021952;40885482", "class_list": "", "function": "Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (By similarity). May act by linking the adapter protein complex AP-1 to other proteins (By similarity). Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity)., [UniProtKB, UniProtKB]; Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins. Component of clathrin-coated vesicles. Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q5SV84;Q6PHT6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0030130 clathrin coat of trans-Golgi network vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q5SV85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHT7-1", "uniprot_id": "TF3A_MOUSE", "mass": 41571.0, "length": 364, "protein_name": "Transcription factor IIIA", "gene_name": "Gtf3a", "organism": "Mouse", "refseq_name": "transcription factor IIIA", "refseq_ac": "NP_079928", "gene_names_uniprotkb": "Gtf3a", "gene_names_refseq": "2010015D03Rik; 2610111I01Rik; 5330403M05Rik; Gtf3a", "protein_names_uniprotkb": "Transcription factor IIIA; TFIIIA", "protein_names_refseq": "TFIIIA; factor A; transcription factor IIIA", "tax_id": 10090, "disease": "", "pathway": " (mmu:66596); (R-MMU-76061)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11814676;21750661;32782141", "class_list": "", "function": "Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (By similarity). Also binds the transcribed 5S RNA's (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJ79;Q8K270;Q9CSH8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0008097 5S rRNA binding;GO:0000995 RNA polymerase III general transcription initiation factor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006351 DNA-templated transcription;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VHT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61957-1", "uniprot_id": "SUMO2_MOUSE", "mass": 10871.0, "length": 95, "protein_name": "Small ubiquitin-related modifier 2", "gene_name": "Sumo2", "organism": "Mouse", "refseq_name": "small ubiquitin-related modifier 2", "refseq_ac": "NP_579932", "gene_names_uniprotkb": "Sumo2; Smt3b; Smt3h2", "gene_names_refseq": "SUMO-2; Smt3A; Smt3b; Smt3h2; Sumo2", "protein_names_uniprotkb": "Small ubiquitin-related modifier 2; SMT3 homolog 2; SUMO-2; Smt3B; Ubiquitin-like protein SMT3B", "protein_names_refseq": "SMT3 homolog 2; SMT3 suppressor of mif two 3 homolog 2; SMT3 supressor of mif two 3 homolog 2; sentrin-2; small ubiquitin-related modifier 2; ubiquitin-like protein SMT3A; ubiquitin-like protein SMT3B", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:170930); (R-MMU-196791); (R-MMU-3065679); (R-MMU-3108214); (R-MMU-3232118); (R-MMU-3899300); (R-MMU-4085377); (R-MMU-4090294); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-5693607); (R-MMU-5696395)", "pathway_count": 13, "publication_count": 8, "publication_id_list": "21750661;23806337;28135057;31088288;36288343;37890757;40997131;9891849", "class_list": "", "function": "Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice., [RefSeq, PubMed]; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A9X2;P55855;Q542L8", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0019789 SUMO transferase activity;GO:0046965 nuclear retinoid X receptor binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0031386 protein tag activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0098794 postsynapse", "go_biological_process": "GO:0016925 protein sumoylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P61957-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TUH1-1", "uniprot_id": "TAM41_MOUSE", "mass": 37828.0, "length": 337, "protein_name": "Phosphatidate cytidylyltransferase, mitochondrial", "gene_name": "Tamm41", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tamm41; 1500001M20Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase, mitochondrial; 2.7.7.41; CDP-DAG synthase; CDP-diacylglycerol synthase; Mitochondrial translocator assembly and maintenance protein 41 homolog; TAM41", "protein_names_refseq": "", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 56 (Disease Ontology:DOID:0070429); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:68971)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.41", "go_molecular_function": "GO:0004605 phosphatidate cytidylyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0032049 cardiolipin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TUH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58021-1", "uniprot_id": "TM9S2_MOUSE", "mass": 75330.0, "length": 662, "protein_name": "Transmembrane 9 superfamily member 2", "gene_name": "Tm9sf2", "organism": "Mouse", "refseq_name": "transmembrane 9 superfamily member 2 precursor", "refseq_ac": "NP_542123", "gene_names_uniprotkb": "Tm9sf2", "gene_names_refseq": "1500001N15Rik; D14Ertd64e; P76; Tm9sf2", "protein_names_uniprotkb": "Transmembrane 9 superfamily member 2", "protein_names_refseq": "transmembrane 9 superfamily member 2 precursor", "tax_id": 10090, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:68059)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "16075062;20173027;21750661;26740625;30084848;31219806;34203471;34428180;35984892;36210013;37453647;37828378", "class_list": "", "function": "In the intracellular compartments, may function as a channel or small molecule transporter., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005815 microtubule organizing center;GO:0010008 endosome membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0006672 ceramide metabolic process;GO:0072657 protein localization to membrane;GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P58021-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z108-1", "uniprot_id": "STAU1_MOUSE", "mass": 53925.0, "length": 487, "protein_name": "Double-stranded RNA-binding protein Staufen homolog 1", "gene_name": "Stau1", "organism": "Mouse", "refseq_name": "double-stranded RNA-binding protein Staufen homolog 1 isoform 3", "refseq_ac": "NP_035620", "gene_names_uniprotkb": "Stau1; Stau", "gene_names_refseq": "5830401L18Rik; Stau1; Stau", "protein_names_uniprotkb": "Double-stranded RNA-binding protein Staufen homolog 1", "protein_names_refseq": "double-stranded RNA-binding protein Staufen homolog 1 isoform 3; double-stranded RNA-binding protein Staufen homolog 1; staufen (RNA binding protein) homolog 1", "tax_id": 10090, "disease": "atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (mmu:20853)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10022909;12147688;21750661;24129315;25428506;28135057;28528544;34428180;34678304;34887587;36871938;38729552;38913026", "class_list": "", "function": "Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration., [RefSeq, PubMed]; Identification of mRNA/protein (mRNP) complexes and their association with rough endoplasmic reticulum equipeed with a kinesin motor, [RefSeq, PubMed]; STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells., [RefSeq, PubMed]; STAU1 promotes adipogenesis by regulating the alternative splicing of Ppargamma2 mRNA., [RefSeq, PubMed]; Staufen 1 is expressed by neural precursor cells in the developing murine cortex but is dispensable for NPC self-renewal and neuronal differentiation in vitro., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003725 double-stranded RNA binding;GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0046726 positive regulation by virus of viral protein levels in host cell;GO:0098963 dendritic transport of messenger ribonucleoprotein complex;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0050804 modulation of chemical synaptic transmission;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9Z108-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AWJ5-1", "uniprot_id": "TMM8B_MOUSE", "mass": 52114.0, "length": 472, "protein_name": "Transmembrane protein 8B", "gene_name": "Tmem8b", "organism": "Mouse", "refseq_name": "transmembrane protein 8B isoform 1", "refseq_ac": "NP_001078977", "gene_names_uniprotkb": "Tmem8b", "gene_names_refseq": "4930500O05Rik; Tmem8b", "protein_names_uniprotkb": "Transmembrane protein 8B; Protein NGX6", "protein_names_refseq": "transmembrane protein 8B isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:242409)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B9EJV2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B1AWJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0Z3-1", "uniprot_id": "TMM53_MOUSE", "mass": 31589.0, "length": 276, "protein_name": "Transmembrane protein 53", "gene_name": "Tmem53", "organism": "Mouse", "refseq_name": "transmembrane protein 53 isoform a", "refseq_ac": "NP_001272741", "gene_names_uniprotkb": "Tmem53; Net4", "gene_names_refseq": "1110038M16Rik; 1500001P22Rik; 1700012A05Rik; Tmem53", "protein_names_uniprotkb": "Transmembrane protein 53; Nuclear envelope transmembrane protein 4", "protein_names_refseq": "nuclear envelope transmembrane protein 4; transmembrane protein 53 isoform a", "tax_id": 10090, "disease": "craniotubular dysplasia Ikegawa type (Disease Ontology:DOID:0112340)", "pathway": " (mmu:68777)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12958361;17971504;20091084;21750661;25428506;30084848;33824347", "class_list": "", "function": "Negatively regulates bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD1/5/9 proteins., [UniProtKB, PubMed]; Tmem53 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AE66;Q8VDW5;Q9DAF0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0046822 regulation of nucleocytoplasmic transport;GO:0030514 negative regulation of BMP signaling pathway;GO:0045668 negative regulation of osteoblast differentiation;GO:0030279 negative regulation of ossification", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D0Z3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYI9-1", "uniprot_id": "TENR_MOUSE", "mass": 149589.0, "length": 1358, "protein_name": "Tenascin-R", "gene_name": "Tnr", "organism": "Mouse", "refseq_name": "tenascin-R precursor", "refseq_ac": "NP_071707", "gene_names_uniprotkb": "Tnr", "gene_names_refseq": "J1-tenascin; TN-R; Tnr; janusin; restrictin", "protein_names_uniprotkb": "Tenascin-R; Janusin; Neural recognition molecule J1-160/180; Restrictin; TN-R", "protein_names_refseq": "neural recognition molecule J1-160/180; tenascin-R precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:21960); (R-MMU-3000178)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10341229;10383637;10406848;10773191;17114649;21750661;2477380;30899004;33300544;40885482;7678967;9169525", "class_list": "glycogene", "function": "Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediates inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 4, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 17, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 68, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 49, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "A2RT70;O88717", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0046625 sphingolipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0045121 membrane raft", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0007399 nervous system development;GO:0008306 associative learning;GO:0030155 regulation of cell adhesion;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 7.6, "record_id": "Q8BYI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2TV84-1", "uniprot_id": "TRPM1_MOUSE", "mass": 183527.0, "length": 1622, "protein_name": "Transient receptor potential cation channel subfamily M member 1", "gene_name": "Trpm1", "organism": "Mouse", "refseq_name": "transient receptor potential cation channel subfamily M member 1 isoform 2", "refseq_ac": "NP_001034193", "gene_names_uniprotkb": "Trpm1; Ltrpc1", "gene_names_refseq": "4732499L03Rik; Ltrpc1; Mlsn1; Trpm1; rd15", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 1; LTrpC1; Long transient receptor potential channel 1; Melastatin-1", "protein_names_refseq": "long transient receptor potential channel 1; melastatin-1; transient receptor potential cation channel subfamily M member 1 isoform 2", "tax_id": 10090, "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); MASA syndrome (Disease Ontology:DOID:0060246); chromosome 15q13.3 microdeletion syndrome (Disease Ontology:DOID:0060394); congenital stationary night blindness 1C (Disease Ontology:DOID:0110867)", "pathway": " (mmu:17364); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "15856355;19861548;19966281;21734298;21750661;21832182;24114537;24790204;25112866;25428506;26883481;31219806;32152506;33122432;9537257", "class_list": "", "function": "Constitutively open nonselective divalent cation-conducting channels which mediate the influx of Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization. Impermeable to zinc ions. In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions. Plays an essential role for the depolarizing photoresponse of retinal ON bipolar cells (PubMed:19861548). In the dark, tonic release of glutamate activates the G protein-coupled receptor for glutamate (GRM6), its activation induces the release of G(o) and the beta-gamma G protein dimer. Both subunits can interact and inactivate the TRPM1 channel. A light onset, induces decrease in glutamate release and deactivation of GRM6 leading to channel opening and membrane depolarization (PubMed:19966281, PubMed:26883481). May play a role in metastasis suppression (PubMed:9537257)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; These results demonstrate that TRPM1-L is a component of the ON bipolar cell (BC) transduction channel downstream of mGluR6 in ON BCs., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O70334;Q2WEA6;Q3TPG5;Q3UEW7;Q3UFV6;Q3UFW1;Q3UG69;Q5U4B3;Q640P5", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0008324 monoatomic cation transmembrane transporter activity;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0035841 new growing cell tip;GO:0051286 cell tip;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007165 signal transduction;GO:0051262 protein tetramerization;GO:0006816 calcium ion transport;GO:0007601 visual perception;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q2TV84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCA5-1", "uniprot_id": "TMPS4_MOUSE", "mass": 47496.0, "length": 435, "protein_name": "Transmembrane protease serine 4", "gene_name": "Tmprss4", "organism": "Mouse", "refseq_name": "transmembrane protease serine 4 isoform 1", "refseq_ac": "NP_663378", "gene_names_uniprotkb": "Tmprss4; Cap2", "gene_names_refseq": "CAP2; Tmprss4; mCAP2", "protein_names_uniprotkb": "Transmembrane protease serine 4; 3.4.21.-; Channel-activating protease 4; mCAP2", "protein_names_refseq": "channel-activating protease 2; channel-activating protease 4; membrane-type serine protease 2; transmembrane protease serine 4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:214523)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12149280;16524950;21750661;21993886;25428506;29529050;34173918", "class_list": "", "function": "Mutations in conserved residues of mCAP2 located in two protein-protein interacting domains significantly modulated ENaC activation, [RefSeq, PubMed]; Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (By similarity). Seems to be capable of activating ENaC (PubMed:12149280)., [UniProtKB, UniProtKB, PubMed]; TMPRSS4 primarily activates ENaC by cleaving basic residues within the tract gammaK173-K186 distal to the furin cleavage site, thereby releasing a previously defined key inhibitory tract encompassing gammaR158-F168 from the gamma-subunit., [RefSeq, PubMed]; The lung fibrotic response evaluated at 28 days after bleomycin injury was markedly attenuated in the haplodeficient and deficient TMPRSS4 mice. Publication Status: Online-Only, [RefSeq, PubMed]; Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis. Erratum:[Bull Exp Biol Med. 2021 Nov;172(1):112. doi: 10.1007/s10517-021-05343-9. PMID: 34796428], [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0009611 response to wounding;GO:0046598 positive regulation of viral entry into host cell;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VCA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2M0-1", "uniprot_id": "TEAN2_MOUSE", "mass": 24200.0, "length": 207, "protein_name": "Transcription elongation factor A N-terminal and central domain-containing protein 2", "gene_name": "Tceanc2", "organism": "Mouse", "refseq_name": "transcription elongation factor A N-terminal and central domain-containing protein 2", "refseq_ac": "NP_079893", "gene_names_uniprotkb": "Tceanc2; 2210012G02Rik; Tdeanc2", "gene_names_refseq": "2210010B22Rik; 2210012G02Rik; 6330404A07Rik; Tceanc2; Tdeanc2", "protein_names_uniprotkb": "Transcription elongation factor A N-terminal and central domain-containing protein 2", "protein_names_refseq": "transcription elongation factor A N-terminal and central domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66526)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZZ2;Q9D7X9", "ec_number_list": "", "go_molecular_function": "GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006368 transcription elongation by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2M0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17532-1", "uniprot_id": "TPH1_MOUSE", "mass": 51343.0, "length": 447, "protein_name": "Tryptophan 5-hydroxylase 1", "gene_name": "Tph1", "organism": "Mouse", "refseq_name": "tryptophan 5-hydroxylase 1 isoform 1", "refseq_ac": "NP_001129556", "gene_names_uniprotkb": "Tph1; Tph", "gene_names_refseq": "Tph1; Tph", "protein_names_uniprotkb": "Tryptophan 5-hydroxylase 1; 1.14.16.4; Tryptophan 5-monooxygenase 1", "protein_names_refseq": "tryptophan 5-hydroxylase 1 isoform 1; tryptophan 5-hydroxylase 1; tryptophan 5-monooxygenase 1", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); scoliosis (Disease Ontology:DOID:0060249); Alzheimer's disease (Disease Ontology:DOID:10652); borderline personality disorder (Disease Ontology:DOID:10930); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); schizophrenia (Disease Ontology:DOID:5419); postpartum depression (Disease Ontology:DOID:9478); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:21990); (R-MMU-209931)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14697203;18299400;2110547;21750661;39695187", "class_list": "", "function": "Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase family. The encoded protein is one of two tryptophan hydroxylase enzymes that catalyze the first and rate limiting step in the biosynthesis of the hormone and neurotransmitter, serotonin. This gene is expressed in peripheral organs, while tryptophan hydroxylase 2 is expressed in neurons. The encoded protein is involved in the development of hypoxia-induced elevations in pulmonary pressures and pulmonary vascular remodeling, and has also been implicated as a regulator of immune tolerance. Disruption of this gene is associated with cardiac dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.16.4", "go_molecular_function": "GO:0004510 tryptophan 5-monooxygenase activity;GO:0005506 iron ion binding;GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043005 neuron projection", "go_biological_process": "GO:0002576 platelet degranulation;GO:0045600 positive regulation of fat cell differentiation;GO:0046849 bone remodeling;GO:0060749 mammary gland alveolus development;GO:0030279 negative regulation of ossification", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P17532-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62500-1", "uniprot_id": "T22D1_MOUSE", "mass": 109811.0, "length": 1077, "protein_name": "TSC22 domain family protein 1", "gene_name": "Tsc22d1", "organism": "Mouse", "refseq_name": "TSC22 domain family protein 1 isoform 2", "refseq_ac": "NP_033392", "gene_names_uniprotkb": "Tsc22d1; Kiaa1994; Tgfb1i4; Tilz1b; Tsc22", "gene_names_refseq": "Egr5; Gm19597; TSC-22; Tgfb1i4; Tsc22d1; Tsc22; Tsc", "protein_names_uniprotkb": "TSC22 domain family protein 1; Regulatory protein TSC-22; TGFB-stimulated clone 22 homolog; TSC22-related inducible leucine zipper 1b; Transforming growth factor beta-1-induced transcript 4 protein", "protein_names_refseq": "TSC22 domain family protein 1 isoform 2; Tgfb-stimulated clone 22 homolog; Tsc22-related inducible leucine zipper 1b; regulatory protein Tsc22; transforming growth factor beta 1 induced transcript 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:21807)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12468551;1587811;17147695;19329776;19745830;20713358;21750661;22645316;26752201;26872059;31599954;32848054;34428180;36759189;39927985", "class_list": "", "function": "High TSC-22 expression is associated with obesity, splenic abnormality and B cell lymphoma., [RefSeq, PubMed]; May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells., [UniProtKB, PubMed]; Neurovascular Development in Pten and Tsc2 Mouse Mutants. Publication Status: Online-Only, [RefSeq, PubMed]; Positively regulates cell death in response to TGFB3 during mammary gland involution., [UniProtKB, PubMed]; Transcriptional repressor (By similarity). Acts on the C-type natriuretic peptide (CNP) promoter (By similarity). Acts to promote CASP3-mediated apoptosis (By similarity). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (By similarity). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (By similarity). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (PubMed:20713358). Plays a role in the repression of hematopoietic precursor cell growth (PubMed:19329776). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q00992;Q69Z44;Q6PDK1;Q9EQN4", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P62500-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C341-1", "uniprot_id": "SUCO_MOUSE", "mass": 139169.0, "length": 1250, "protein_name": "SUN domain-containing ossification factor", "gene_name": "Suco", "organism": "Mouse", "refseq_name": "SUN domain-containing ossification factor isoform 3 precursor", "refseq_ac": "NP_001344331", "gene_names_uniprotkb": "Suco; Opt", "gene_names_refseq": "4732491B11; Opt; Suco", "protein_names_uniprotkb": "SUN domain-containing ossification factor; Membrane protein CH1; Protein osteopotentia; SUN-like protein 1", "protein_names_refseq": "SUN domain-containing ossification factor isoform 3 precursor; SUN-like protein 1; membrane protein CH1; protein C1orf9 homolog; protein osteopotentia", "tax_id": 10090, "disease": "osteogenesis imperfecta type 5 (Disease Ontology:DOID:0110344)", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;20440000;21750661;25668491;30899004;34428180;36852467", "class_list": "", "function": "Neurons have abnormal development due to lack of SUCO, which may be a generalized-onset epilepsy-related gene, [RefSeq, PubMed]; Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice., [RefSeq, PubMed]; Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAG8;Q3V3T1;Q8CE34", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0016020 membrane;GO:0030867 rough endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0032967 positive regulation of collagen biosynthetic process;GO:0045669 positive regulation of osteoblast differentiation;GO:0001503 ossification;GO:0046850 regulation of bone remodeling", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q8C341-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7S1-1", "uniprot_id": "TMM54_MOUSE", "mass": 23427.0, "length": 219, "protein_name": "Transmembrane protein 54", "gene_name": "Tmem54", "organism": "Mouse", "refseq_name": "transmembrane protein 54 isoform 3", "refseq_ac": "NP_001277635", "gene_names_uniprotkb": "Tmem54", "gene_names_refseq": "1810017F10Rik; Tmem54", "protein_names_uniprotkb": "Transmembrane protein 54", "protein_names_refseq": "transmembrane protein 54 isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66260)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A7R3;Q8VCL0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D7S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5I4-1", "uniprot_id": "DYLT5_MOUSE", "mass": 19680.0, "length": 173, "protein_name": "Dynein light chain Tctex-type 5", "gene_name": "Dynlt5", "organism": "Mouse", "refseq_name": "dynein light chain Tctex-type 5 isoform 1", "refseq_ac": "NP_001157239", "gene_names_uniprotkb": "Dynlt5; Tctex1d1", "gene_names_refseq": "1700055O19Rik; Dynlt5; Tctex1d1", "protein_names_uniprotkb": "Dynein light chain Tctex-type 5; Tctex1 domain-containing protein 1", "protein_names_refseq": "Tctex1 domain containing 1; dynein light chain Tctex-type 5 isoform 1; tctex1 domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67344); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZP4;Q9CVR8", "ec_number_list": "", "go_molecular_function": "GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D5I4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYK1-1", "uniprot_id": "SYWM_MOUSE", "mass": 40153.0, "length": 360, "protein_name": "Tryptophan--tRNA ligase, mitochondrial", "gene_name": "Wars2", "organism": "Mouse", "refseq_name": "tryptophan--tRNA ligase, mitochondrial isoform 1", "refseq_ac": "NP_081738", "gene_names_uniprotkb": "Wars2", "gene_names_refseq": "5730427B17Rik; 9430020O07Rik; TrpRS; Wars2", "protein_names_uniprotkb": "Tryptophan--tRNA ligase, mitochondrial; (Mt)TrpRS; 6.1.1.2; TrpRS; Tryptophanyl-tRNA synthetase", "protein_names_refseq": "(Mt)TrpRS; tryptophan--tRNA ligase, mitochondrial isoform 1; tryptophan--tRNA ligase, mitochondrial; tryptophanyl-tRNA synthetase, mitochondrial", "tax_id": 10090, "disease": "movement disease (Disease Ontology:DOID:480); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:70560)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;30566859;35820727", "class_list": "", "function": "Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of tRNA(Trp)., [UniProtKB, UniProtKB]; The characterization of a mouse model harboring a mutation in the tryptophanyl-tRNA synthetase 2 (Wars2) gene, encoding the mitochondrial-localized WARS2 protein, is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BFV8", "ec_number_list": "6.1.1.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0004830 tryptophan-tRNA ligase activity;GO:0004812 aminoacyl-tRNA ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005886 plasma membrane", "go_biological_process": "GO:0001570 vasculogenesis;GO:0045766 positive regulation of angiogenesis;GO:0070183 mitochondrial tryptophanyl-tRNA aminoacylation;GO:0006436 tryptophanyl-tRNA aminoacylation;GO:0006418 tRNA aminoacylation for protein translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CYK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUV2-1", "uniprot_id": "SIA7C_MOUSE", "mass": 35414.0, "length": 305, "protein_name": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3", "gene_name": "St6galnac3", "organism": "Mouse", "refseq_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 1", "refseq_ac": "NP_035502", "gene_names_uniprotkb": "St6galnac3; Siat7c", "gene_names_refseq": "Siat7c; St6galnac3", "protein_names_uniprotkb": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; 2.4.3.7; GalNAc alpha-2,6-sialyltransferase III; SIAT7-C; ST6GalNAc III; ST6GalNAcIII; STY; Sialyltransferase 7C", "protein_names_refseq": "SIAT7-C; ST6GalNAc III; ST6GalNAcIII; STY; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 1; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; galNAc alpha-2,6-sialyltransferase III; sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C; sialyltransferase 7C", "tax_id": 10090, "disease": "", "pathway": " (mmu:20447); (R-MMU-4085001); (R-MMU-977068)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10207017;10601645;21750661;30084848;37386100", "class_list": "glycogene;glycosyltransferase", "function": "Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes. Publication Status: Online-Only, [RefSeq, PubMed]; Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:10207017, PubMed:10601645). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHP5", "ec_number_list": "2.4.3.3;2.4.99.-;2.4.3.7", "go_molecular_function": "GO:0008373 sialyltransferase activity;GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;GO:0047290 alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006687 glycosphingolipid metabolic process;GO:0009311 oligosaccharide metabolic process;GO:0009100 glycoprotein metabolic process;GO:0006677 glycosylceramide metabolic process", "synthesized_glycan_count": 550, "hit_score": 0.9, "record_id": "Q9WUV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WA1-1", "uniprot_id": "TIPIN_MOUSE", "mass": 31498.0, "length": 278, "protein_name": "TIMELESS-interacting protein", "gene_name": "Tipin", "organism": "Mouse", "refseq_name": "TIMELESS-interacting protein", "refseq_ac": "NP_001311485", "gene_names_uniprotkb": "Tipin", "gene_names_refseq": "1110005A05Rik; 1110018P21Rik; Tipin", "protein_names_uniprotkb": "TIMELESS-interacting protein", "protein_names_refseq": "TIMELESS-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66131); (R-MMU-5693607)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12875843;17141802;19805627;21750661;34428180", "class_list": "", "function": "MTIM promotes the nuclear localization of TIPIN, and TIPIN is capable of regulating mTIM activity by disrupting the ability of mTIM to form homo-multimeric complexes, [RefSeq, PubMed]; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs., [RefSeq, PubMed]; The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. [provided by RefSeq, Feb 2014]., [RefSeq]; The tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQM3;Q9D1J4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0031298 replication fork protection complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0008284 positive regulation of cell population proliferation;GO:0051301 cell division;GO:0009411 response to UV;GO:0031573 mitotic intra-S DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91WA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P3Z3-1", "uniprot_id": "THAP4_MOUSE", "mass": 62571.0, "length": 569, "protein_name": "Peroxynitrite isomerase THAP4", "gene_name": "Thap4", "organism": "Mouse", "refseq_name": "peroxynitrite isomerase THAP4 isoform 2", "refseq_ac": "NP_001297690", "gene_names_uniprotkb": "Thap4", "gene_names_refseq": "2010320B01Rik; Nb(III); Thap4", "protein_names_uniprotkb": "Peroxynitrite isomerase THAP4; 5.99.-.-; Ferric nitrobindin; Nb(III); THAP domain-containing protein 4", "protein_names_refseq": "THAP domain-containing protein 4; ferric nitrobindin; peroxynitrite isomerase THAP4 isoform 2; peroxynitrite isomerase THAP4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67026)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;38658415", "class_list": "", "function": "Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3US28;Q6NZN6;Q6PEN6;Q91WR2;Q9CVE5;Q9CVG3", "ec_number_list": "5.99.-.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0020037 heme binding;GO:0070026 nitric oxide binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042126 nitrate metabolic process;GO:0006570 tyrosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P3Z3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TN84-1", "uniprot_id": "SYT14_MOUSE", "mass": 62044.0, "length": 555, "protein_name": "Synaptotagmin-14", "gene_name": "Syt14", "organism": "Mouse", "refseq_name": "synaptotagmin-14 isoform 2", "refseq_ac": "NP_853524", "gene_names_uniprotkb": "Syt14", "gene_names_refseq": "B230320I09Rik; Syt14; sytXIV", "protein_names_uniprotkb": "Synaptotagmin-14; Synaptotagmin XIV; SytXIV", "protein_names_refseq": "synaptotagmin-14 isoform 2; synaptotagmin-14", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 11 (Disease Ontology:DOID:0080063)", "pathway": " (mmu:329324)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12801916;21750661;21835308", "class_list": "", "function": "May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the synaptotagmin family. The encoded protein may be involved in membrane trafficking. Disruption of a similar gene in human has been associated with autosomal recessive spinocerebellar ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TN84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B7ZWI3-1", "uniprot_id": "TMM92_MOUSE", "mass": 18079.0, "length": 162, "protein_name": "Transmembrane protein 92", "gene_name": "Tmem92", "organism": "Mouse", "refseq_name": "transmembrane protein 92 isoform 2 precursor", "refseq_ac": "NP_001030068", "gene_names_uniprotkb": "Tmem92", "gene_names_refseq": "Tmem92-ps; Tmem92", "protein_names_uniprotkb": "Transmembrane protein 92", "protein_names_refseq": "transmembrane protein 92 isoform 2 precursor; transmembrane protein 92, pseudogene", "tax_id": 10090, "disease": "", "pathway": " (mmu:544806)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q2K3;Q3UT21", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B7ZWI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61939-1", "uniprot_id": "THBG_MOUSE", "mass": 47052.0, "length": 418, "protein_name": "Thyroxine-binding globulin", "gene_name": "Serpina7", "organism": "Mouse", "refseq_name": "thyroxine-binding globulin isoform 2 precursor", "refseq_ac": "NP_001369300", "gene_names_uniprotkb": "Serpina7; Tbg", "gene_names_refseq": "C730040N12Rik; Serpina7; Tbg", "protein_names_uniprotkb": "Thyroxine-binding globulin; Serpin A7; T4-binding globulin", "protein_names_refseq": "T4-binding globulin; serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antipeptidase, antitrypsin), member 7; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; serpin A7; thyroxine-binding globulin isoform 2 precursor; thyroxine-binding globulin", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); hypothyroidism (Disease Ontology:DOID:1459); diabetic ketoacidosis (Disease Ontology:DOID:1837); hyperthyroidism (Disease Ontology:DOID:7998); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:331535)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;22820390", "class_list": "", "function": "Major thyroid hormone transport protein in serum., [UniProtKB]; The TBG promoter has a role in sustaining transgene expression in liver-specific pattern, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A2RSG7", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0042562 hormone binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0009791 post-embryonic development;GO:0033189 response to vitamin A;GO:0043434 response to peptide hormone;GO:0009410 response to xenobiotic stimulus;GO:0070327 thyroid hormone transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61939-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q497J1-1", "uniprot_id": "TM86B_MOUSE", "mass": 24989.0, "length": 226, "protein_name": "Lysoplasmalogenase TMEM86B", "gene_name": "Tmem86b", "organism": "Mouse", "refseq_name": "lysoplasmalogenase TMEM86B", "refseq_ac": "NP_075929", "gene_names_uniprotkb": "Tmem86b", "gene_names_refseq": "C330014O21Rik; Tmem86b", "protein_names_uniprotkb": "Lysoplasmalogenase TMEM86B; 3.3.2.2; Transmembrane protein 86B", "protein_names_refseq": "lysoplasmalogenase TMEM86B; lysoplasmalogenase", "tax_id": 10090, "disease": "", "pathway": " (mmu:68255); (R-MMU-1482788)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21515882;21750661;34428180", "class_list": "", "function": "Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.3.2.2", "go_molecular_function": "GO:0047408 alkenylglycerophosphocholine hydrolase activity;GO:0042802 identical protein binding;GO:0047826 D-lysine 5,6-aminomutase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046485 ether lipid metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q497J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC04-1", "uniprot_id": "T106A_MOUSE", "mass": 29109.0, "length": 261, "protein_name": "Transmembrane protein 106A", "gene_name": "Tmem106a", "organism": "Mouse", "refseq_name": "transmembrane protein 106A", "refseq_ac": "NP_659079", "gene_names_uniprotkb": "Tmem106a", "gene_names_refseq": "0610008L10Rik; Tmem106a", "protein_names_uniprotkb": "Transmembrane protein 106A", "protein_names_refseq": "transmembrane protein 106A", "tax_id": 10090, "disease": "", "pathway": " (mmu:217203)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26215746;27802388;33006758", "class_list": "", "function": "Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway (PubMed:26215746). Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (PubMed:26215746). May play a role in inhibition of proliferation and migration (By similarity)., [UniProtKB, UniProtKB, PubMed]; Data suggest that mouse Tmem106a might be a new trigger of macrophage activation and have some influence toward the M1 state through the activation of the MAPKs and NF-kappaB pathway Publication Status: Online-Only, [RefSeq, PubMed]; Inactivation of TMEM106A promotes lipopolysaccharide-induced inflammation via the MAPK and NF-kappaB signaling pathways in macrophages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4J0;Q3U9D3;Q3UEA5;Q8CIC3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0045087 innate immune response;GO:0042116 macrophage activation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VC04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0V8-1", "uniprot_id": "TI17A_MOUSE", "mass": 18112.0, "length": 171, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim17-A", "gene_name": "Timm17a", "organism": "Mouse", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim17-A isoform 2", "refseq_ac": "NP_035720", "gene_names_uniprotkb": "Timm17a; Tim17a", "gene_names_refseq": "Tim17a; Timm17a; mTim17a", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim17-A; Inner membrane preprotein translocase Tim17a", "protein_names_refseq": "inner membrane preprotein translocase Tim17a; mitochondrial import inner membrane translocase subunit Tim17-A isoform 2; mitochondrial import inner membrane translocase subunit Tim17-A; translocator of inner mitochondrial membrane 17 kDa, a; translocator of inner mitochondrial membrane 17a", "tax_id": 10090, "disease": "", "pathway": " (mmu:21854)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10339406;21750661", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0010954 positive regulation of protein processing;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z0V8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGV0-1", "uniprot_id": "SYNM_MOUSE", "mass": 53962.0, "length": 477, "protein_name": "Asparaginyl-tRNA synthetase", "gene_name": "Nars2", "organism": "Mouse", "refseq_name": "asparaginyl-tRNA synthetase precursor", "refseq_ac": "NP_705819", "gene_names_uniprotkb": "Nars2", "gene_names_refseq": "Nars2", "protein_names_uniprotkb": "Asparaginyl-tRNA synthetase; 6.1.1.22; AsnRS; Asparagine--tRNA ligase, mitochondrial; NARS2", "protein_names_refseq": "asnRS; asparagine--tRNA ligase; asparaginyl-tRNA synthetase precursor; probable asparagine--tRNA ligase, mitochondrial; probable asparaginyl-tRNA synthetase, mitochondrial", "tax_id": 10090, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); combined oxidative phosphorylation deficiency 24 (Disease Ontology:DOID:0111485); autosomal recessive nonsyndromic deafness 94 (Disease Ontology:DOID:0111641)", "pathway": " (mmu:244141)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23576753;25807530;37507081", "class_list": "", "function": "In these cells we show that a decrease in oxygen consumption rates (OCR) and electron transport chain (ETC) activity can be rescued by overexpression of wild type NARS2 Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the asparagine amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis (By similarity). The reaction occurs in a two steps: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.1.1.22", "go_molecular_function": "GO:0005524 ATP binding;GO:0003676 nucleic acid binding;GO:0004816 asparagine-tRNA ligase activity;GO:0004812 aminoacyl-tRNA ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006421 asparaginyl-tRNA aminoacylation;GO:0006418 tRNA aminoacylation for protein translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BGV0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P4U0-1", "uniprot_id": "THS7B_MOUSE", "mass": 179309.0, "length": 1607, "protein_name": "Thrombospondin type-1 domain-containing protein 7B", "gene_name": "Thsd7b", "organism": "Mouse", "refseq_name": "thrombospondin type-1 domain-containing protein 7B precursor", "refseq_ac": "NP_766073", "gene_names_uniprotkb": "Thsd7b", "gene_names_refseq": "1700074E13Rik; B930082A18; D130067I03Rik; Thsd7b", "protein_names_uniprotkb": "Thrombospondin type-1 domain-containing protein 7B", "protein_names_refseq": "thrombospondin type-1 domain-containing protein 7B precursor; thrombospondin type-1 domain-containing protein 7B", "tax_id": 10090, "disease": "", "pathway": " (mmu:210417); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;39161765", "class_list": "", "function": "Exercise-augmented THSD7B exhibited a positive prognostic implication and tumor-suppressed functionality in pan-cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 9, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6P4U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9D5-1", "uniprot_id": "TMC5A_MOUSE", "mass": 33972.0, "length": 288, "protein_name": "Transmembrane and coiled-coil domain-containing protein 5A", "gene_name": "Tmco5a; Tmco5", "organism": "Mouse", "refseq_name": "transmembrane and coiled-coil domain-containing protein 5A isoform 1", "refseq_ac": "NP_080380", "gene_names_uniprotkb": "Tmco5a; Tmco5; Tmco5", "gene_names_refseq": "1700095F04Rik; Tmco5a; Tmco5", "protein_names_uniprotkb": "Transmembrane and coiled-coil domain-containing protein 5A", "protein_names_refseq": "transmembrane and coiled-coil domain-containing protein 5A isoform 1; transmembrane and coiled-coil domain-containing protein 5A; transmembrane and coiled-coil domains 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:67356)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;28742876;31393949", "class_list": "", "function": "Tmco5 may have a role in vesicle transport along the manchette. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ARB1;Q9CVN5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D9D5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKU8-1", "uniprot_id": "TM87B_MOUSE", "mass": 62898.0, "length": 555, "protein_name": "Transmembrane protein 87B", "gene_name": "Tmem87b", "organism": "Mouse", "refseq_name": "transmembrane protein 87B isoform b precursor", "refseq_ac": "NP_082524", "gene_names_uniprotkb": "Tmem87b", "gene_names_refseq": "2610301K12Rik; 2810431I02Rik; Tmem87b", "protein_names_uniprotkb": "Transmembrane protein 87B", "protein_names_refseq": "novel lung seven transmembrane receptor domain containing protein; transmembrane protein 87B isoform b precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:72477)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34418053", "class_list": "", "function": "May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AN76;Q3T9D2;Q8K0G0;Q9D001", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BKU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D710-1", "uniprot_id": "TMX2_MOUSE", "mass": 33943.0, "length": 295, "protein_name": "Thioredoxin-related transmembrane protein 2", "gene_name": "Tmx2", "organism": "Mouse", "refseq_name": "thioredoxin-related transmembrane protein 2 isoform b", "refseq_ac": "NP_001277680", "gene_names_uniprotkb": "Tmx2; Txndc14", "gene_names_refseq": "2310042M24Rik; Tmx2; Txndc14", "protein_names_uniprotkb": "Thioredoxin-related transmembrane protein 2; Thioredoxin domain-containing protein 14", "protein_names_refseq": "thioredoxin domain containing 14; thioredoxin domain-containing protein 14; thioredoxin-related transmembrane protein 2 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:66958)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21183079;21750661;25428506;25605945;30084848;30779550;31219806;34428180", "class_list": "", "function": "Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BW13", "ec_number_list": "", "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D710-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97358-1", "uniprot_id": "TAF1B_MOUSE", "mass": 67954.0, "length": 586, "protein_name": "TATA box-binding protein-associated factor RNA polymerase I subunit B", "gene_name": "Taf1b", "organism": "Mouse", "refseq_name": "TATA box-binding protein-associated factor RNA polymerase I subunit B", "refseq_ac": "NP_065639", "gene_names_uniprotkb": "Taf1b", "gene_names_refseq": "4930408G01Rik; A230108M10Rik; TAFI68; Taf1b; Tafi86; p63", "protein_names_uniprotkb": "TATA box-binding protein-associated factor RNA polymerase I subunit B; RNA polymerase I-specific TBP-associated factor 68 kDa; TAFI68; TATA box-binding protein-associated factor 1B; TBP-associated factor 1B; Transcription initiation factor SL1/TIF-IB subunit B", "protein_names_refseq": "RNA polymerase I-specific TBP-associated factor 68 kDa; TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B; TATA box-binding protein-associated factor 1B; TATA box-binding protein-associated factor RNA polymerase I subunit B; TBP-associated factor 1B; TBP-associated factor RNA polymerase I 68; transcription factor TAFI68; transcription initiation factor SL1/TIF-IB subunit B", "tax_id": 10090, "disease": "mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); Lynch syndrome (Disease Ontology:DOID:3883)", "pathway": " (mmu:21340); (R-MMU-5250924); (R-MMU-73762); (R-MMU-73772); (R-MMU-73863)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "12015311;21228480;21750661;9050847", "class_list": "", "function": "Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QJY7;Q08AT7;Q3V292;Q6NSS9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005668 RNA polymerase transcription factor SL1 complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0070860 RNA polymerase I core factor complex;GO:0000120 RNA polymerase I transcription regulator complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0006355 regulation of DNA-templated transcription;GO:0042790 nucleolar large rRNA transcription by RNA polymerase I;GO:0001188 RNA polymerase I preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P97358-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36371-1", "uniprot_id": "TAP2_MOUSE", "mass": 77445.0, "length": 702, "protein_name": "Antigen peptide transporter 2", "gene_name": "Tap2", "organism": "Mouse", "refseq_name": "antigen peptide transporter 2", "refseq_ac": "NP_035660", "gene_names_uniprotkb": "Tap2; Abcb3; Ham-2; Ham2", "gene_names_refseq": "ABC18; APT2; Abcb3; Ham-2; Ham2; MTP2; PSF2; RING11; Tap-2; Tap2; Y1; jas", "protein_names_uniprotkb": "Antigen peptide transporter 2; 7.4.2.14; APT2; ATP-binding cassette sub-family B member 3; Histocompatibility antigen modifier 2", "protein_names_refseq": "ATP dependent transport protein family member; ATP-binding cassette sub-family B member 3; ATP-binding cassette, sub-family B (MDR/TAP), member 3; antigen peptide transporter 2; histocompatibility antigen modifier 2; transporter 2 ATP-binding cassette sub-family B; transporter 2, ABC (ATP binding cassette)", "tax_id": 10090, "disease": "lymphoproliferative syndrome (Disease Ontology:DOID:0060704); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); tuberculoid leprosy (Disease Ontology:DOID:1025); Alzheimer's disease (Disease Ontology:DOID:10652); dengue hemorrhagic fever (Disease Ontology:DOID:12206); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); multiple sclerosis (Disease Ontology:DOID:2377); cervix carcinoma (Disease Ontology:DOID:2893); pulmonary tuberculosis (Disease Ontology:DOID:2957); allergic contact dermatitis (Disease Ontology:DOID:3042); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); cervical cancer (Disease Ontology:DOID:4362); reactive arthritis (Disease Ontology:DOID:6196); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:21355); (R-MMU-983170)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "1339432;21750661;25428506;27861817;30084848;30779550;31599954;34428180;35820727", "class_list": "", "function": "ABC transporter associated with antigen processing. In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules. Uses the chemical energy of ATP to export peptides against the concentration gradient. During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle. As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation., [UniProtKB, UniProtKB]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with Tap1 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008]., [RefSeq]; This study show that a new mouse strain with a single point mutation (Tap2 knock-out strain) shows impaired survival of macrophage survival following peritoneal iflammation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.4.2.14;5.3.4.1", "go_molecular_function": "GO:0046978 TAP1 binding;GO:0046979 TAP2 binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0016607 nuclear speck;GO:0005789 endoplasmic reticulum membrane;GO:0042824 MHC class I peptide loading complex", "go_biological_process": "GO:0015031 protein transport;GO:0055085 transmembrane transport;GO:0042270 protection from natural killer cell mediated cytotoxicity;GO:0002250 adaptive immune response;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P36371-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C5P7-1", "uniprot_id": "TDRP_MOUSE", "mass": 20186.0, "length": 182, "protein_name": "Testis development-related protein", "gene_name": "Tdrp", "organism": "Mouse", "refseq_name": "testis development-related protein isoform b", "refseq_ac": "NP_776105", "gene_names_uniprotkb": "Tdrp; 2610019F03Rik", "gene_names_refseq": "2610019F03Rik; Tdrp", "protein_names_uniprotkb": "Testis development-related protein", "protein_names_refseq": "immuno-moodulin; testis development-related protein isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:72148)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;27069551", "class_list": "", "function": "Contributes to normal sperm motility, but not essential for male fertility., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQC8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C5P7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU66-1", "uniprot_id": "SFRP5_MOUSE", "mass": 35382.0, "length": 314, "protein_name": "Secreted frizzled-related protein 5", "gene_name": "Sfrp5", "organism": "Mouse", "refseq_name": "secreted frizzled-related protein 5 precursor", "refseq_ac": "NP_061250", "gene_names_uniprotkb": "Sfrp5", "gene_names_refseq": "SARP3; Sfrp5", "protein_names_uniprotkb": "Secreted frizzled-related protein 5; sFRP-5", "protein_names_refseq": "sFRP-5; secreted frizzled-related protein 5 precursor; secreted frizzled-related protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:54612)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10072424;12972006;21750661;25428506;38422887", "class_list": "", "function": "Here we report that the Secreted frizzled-related protein 5 (Sfrp5) gene, which encodes a secreted factor that can antagonize Wnt signaling, is expressed in the AVE and foregut endoderm during early mouse development, [RefSeq, PubMed]; Silencing of forkhead box C1 reduces nasal epithelial barrier damage in mice with allergic rhinitis via epigenetically upregulating secreted frizzled-related protein 5., [RefSeq, PubMed]; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K269", "ec_number_list": "", "go_molecular_function": "GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0048546 digestive tract morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WU66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D780-1", "uniprot_id": "SLAF9_MOUSE", "mass": 31749.0, "length": 285, "protein_name": "SLAM family member 9", "gene_name": "Slamf9", "organism": "Mouse", "refseq_name": "SLAM family member 9 precursor", "refseq_ac": "NP_083888", "gene_names_uniprotkb": "Slamf9", "gene_names_refseq": "2310026I04Rik; CD2F-10; CD84-H1; Cd2f10; SF2001; Slamf9", "protein_names_uniprotkb": "SLAM family member 9", "protein_names_refseq": "CD2 antigen family, member 10; SLAM family member 9 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:98365)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17322886;21750661;31346085;31880316", "class_list": "", "function": "May play a role in the immune response., [UniProtKB]; SLAMF9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection., [RefSeq, PubMed]; These results suggest the crucial role of SLAMF9 in plasmacytoid dendritic cell differentiation, homeostasis, and function in the steady state and during experimental autoimmune encephalomyelitis. Erratum:[Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19760. doi: 10.1073/pnas.1914890116. PMID: 31527258], [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTK0;Q8VE93", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002273 plasmacytoid dendritic cell differentiation;GO:0006955 immune response;GO:0042110 T cell activation;GO:0042742 defense response to bacterium;GO:0002410 plasmacytoid dendritic cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D780-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCA8-1", "uniprot_id": "SCRN2_MOUSE", "mass": 46601.0, "length": 425, "protein_name": "Secernin-2", "gene_name": "Scrn2", "organism": "Mouse", "refseq_name": "secernin-2", "refseq_ac": "NP_666139", "gene_names_uniprotkb": "Scrn2", "gene_names_refseq": "D11Moh48; SES2; Scrn2", "protein_names_uniprotkb": "Secernin-2", "protein_names_refseq": "secernin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:217140)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016805 dipeptidase activity;GO:0070004 cysteine-type exopeptidase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VCA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WL6-1", "uniprot_id": "SNX11_MOUSE", "mass": 30431.0, "length": 271, "protein_name": "Sorting nexin-11", "gene_name": "Snx11", "organism": "Mouse", "refseq_name": "sorting nexin-11", "refseq_ac": "NP_001156861", "gene_names_uniprotkb": "Snx11", "gene_names_refseq": "4933439F10Rik; A930041K09Rik; Snx11", "protein_names_uniprotkb": "Sorting nexin-11", "protein_names_refseq": "sorting nexin-11", "tax_id": 10090, "disease": "", "pathway": " (mmu:74479)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19144319;21750661;31730264", "class_list": "", "function": "Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Regulates the levels of TRPV3 by promoting its trafficking from the cell membrane to lysosome for degradation., [UniProtKB, UniProtKB]; Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3A6", "ec_number_list": "", "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016050 vesicle organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91WL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4B1-1", "uniprot_id": "SMS2_MOUSE", "mass": 42248.0, "length": 365, "protein_name": "Phosphatidylcholine:ceramide cholinephosphotransferase 2", "gene_name": "Sgms2", "organism": "Mouse", "refseq_name": "phosphatidylcholine:ceramide cholinephosphotransferase 2", "refseq_ac": "NP_083219", "gene_names_uniprotkb": "Sgms2", "gene_names_refseq": "4933405A16Rik; 5133401H06Rik; Sgms2; Sms2", "protein_names_uniprotkb": "Phosphatidylcholine:ceramide cholinephosphotransferase 2; 2.7.8.27; Sms2; Sphingomyelin synthase 2", "protein_names_refseq": "phosphatidylcholine:ceramide cholinephosphotransferase 2", "tax_id": 10090, "disease": "calvarial doughnut lesions with bone fragility (Disease Ontology:DOID:0080721)", "pathway": " (mmu:74442); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14685263;18566297;19590047;21750661;21844222;22580896;22849442;25605874;38609029;39255679", "class_list": "glycogene", "function": "Disruption of sphingomyelin synthase 2 gene alleviates cognitive impairment in a mouse model of Alzheimer's disease., [RefSeq, PubMed]; SMS2 (Sphingomyelin synthase 2) physiologically contributes to de novo Sphingomyelin biosynthesis and plasma membrane Sphingomyelin levels, [RefSeq, PubMed]; SMS2 siRNA inhibits pancreatic tumor growth by tumor microenvironment modulation., [RefSeq, PubMed]; Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane (PubMed:19590047, PubMed:21844222, PubMed:22580896). Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction appears to depend on the levels of CER and DAG in the plasma membrane. Does not use free phosphorylcholine or CDP-choline as donors (By similarity). Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to ceramide (CER) to form ceramide phosphoethanolamine (CPE) (PubMed:25605874). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:19590047, PubMed:21844222). To a lesser extent, plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1. Required for normal bone matrix mineralization (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. [provided by RefSeq, Oct 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 24, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149I0", "ec_number_list": "2.7.8.27;2.7.8.-;3.1.4.62", "go_molecular_function": "GO:0002950 ceramide phosphoethanolamine synthase activity;GO:0033188 sphingomyelin synthase activity;GO:0047493 ceramide cholinephosphotransferase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:1905373 ceramide phosphoethanolamine biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0030500 regulation of bone mineralization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D4B1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7D2-1", "uniprot_id": "SPA9_MOUSE", "mass": 46894.0, "length": 418, "protein_name": "Serpin A9", "gene_name": "Serpina9", "organism": "Mouse", "refseq_name": "serpin A9 precursor", "refseq_ac": "NP_082273", "gene_names_uniprotkb": "Serpina9", "gene_names_refseq": "2310014L03Rik; Centerin; Serpina9", "protein_names_uniprotkb": "Serpin A9", "protein_names_refseq": "serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9; serpin A9 precursor; serpin A9", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831)", "pathway": " (mmu:71907)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16075062;19111575;21750661;34428180", "class_list": "", "function": "Specific antisense oligonucleotides increase pulmonary infiltration of eosinophils in sensitized mice, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D7D2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C263-1", "uniprot_id": "SKA3_MOUSE", "mass": 45370.0, "length": 411, "protein_name": "SKA complex subunit 3", "gene_name": "Ska3", "organism": "Mouse", "refseq_name": "SKA complex subunit 3 isoform 1", "refseq_ac": "NP_941007", "gene_names_uniprotkb": "Ska3; Rama1", "gene_names_refseq": "F630043A04Rik; Ska3", "protein_names_uniprotkb": "SKA complex subunit 3; Spindle and kinetochore-associated protein 3", "protein_names_refseq": "SKA complex subunit 3 isoform 1; SKA complex subunit 3; spindle and kinetochore-associated protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:219114)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22336914;28528544;31219806;34428180;34533066;34678516", "class_list": "", "function": "Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces. The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules. The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase. Within the complex, binds microtubules but with a much lower affinity than SKA1. Promotes stability of the polo-like kinase PLK1 protein (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (PubMed:22336914)., [UniProtKB, UniProtKB, PubMed]; SKA3, negatively regulated by miR-128-3p, promotes the progression of non-small-cell lung cancer., [RefSeq, PubMed]; The Ska3 subunit was only localized on spindle microtubules from the Pro-MI to MII stages in mouse oocyte meiosis and knockdown by Morpholino injection into mouse oocytes resulted in spindle movement defects and enlarged polar bodies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149T5;Q149T6", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0000776 kinetochore;GO:0005876 spindle microtubule;GO:0072687 meiotic spindle", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051310 metaphase chromosome alignment;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C263-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C9X1-1", "uniprot_id": "SNTAN_MOUSE", "mass": 16415.0, "length": 147, "protein_name": "Sentan", "gene_name": "Sntn", "organism": "Mouse", "refseq_name": "sentan", "refseq_ac": "NP_808292", "gene_names_uniprotkb": "Sntn; S100a1l", "gene_names_refseq": "A430083B19Rik; Sntn", "protein_names_uniprotkb": "Sentan; Protein S100-A1-like; S100 calcium-binding protein A1-like", "protein_names_refseq": "sentan", "tax_id": 10090, "disease": "", "pathway": " (mmu:218739)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18829862", "class_list": "", "function": "Data suggest that sentan is the first molecular component of the ciliary tip to bridge the cell membrane and peripheral singlet microtubules, making the distal portion of the cilia narrow and stiff to allow for better airway clearance or ovum transport., [RefSeq, PubMed]; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7FF66", "ec_number_list": "", "go_molecular_function": "GO:0046914 transition metal ion binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C9X1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDC0-1", "uniprot_id": "SPB13_MOUSE", "mass": 44316.0, "length": 389, "protein_name": "Serpin B13", "gene_name": "Serpinb13", "organism": "Mouse", "refseq_name": "serpin B13", "refseq_ac": "NP_766440", "gene_names_uniprotkb": "Serpinb13", "gene_names_refseq": "5430417G24; HUR7; HURPIN; PI13; Serpinb13; headpin", "protein_names_uniprotkb": "Serpin B13", "protein_names_refseq": "serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13; serpin B13", "tax_id": 10090, "disease": "alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (mmu:241196); (R-MMU-8939242)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17697143;20485683;21750661;22593614;30824970;31219806", "class_list": "", "function": "Clade B serpins help to maintain homeostasis by inducing protective humoral immunity, [RefSeq, PubMed]; May play a role in the proliferation or differentiation of keratinocytes., [UniProtKB]; Results suggest an important role of Cat L regulation by hurpin which might be of clinical relevance in human skin diseases, [RefSeq, PubMed]; Serpin B13 inhibition and downstream targeting of E-cadherin by cathepsin L regulates cell proliferation in mouse and human pancreatic islets, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148S5;Q148S6", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0010951 negative regulation of endopeptidase activity;GO:1902173 negative regulation of keratinocyte apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CDC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CEZ1-1", "uniprot_id": "SMCO1_MOUSE", "mass": 24517.0, "length": 214, "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 1", "gene_name": "Smco1", "organism": "Mouse", "refseq_name": "single-pass membrane and coiled-coil domain-containing protein 1", "refseq_ac": "NP_899106", "gene_names_uniprotkb": "Smco1", "gene_names_refseq": "2310010M20Rik; Smco1", "protein_names_uniprotkb": "Single-pass membrane and coiled-coil domain-containing protein 1; Single-pass membrane protein with coiled-coil domains 1", "protein_names_refseq": "single-pass membrane and coiled-coil domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69576)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KMI2;E9PUG1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CEZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGW4-1", "uniprot_id": "SOX30_MOUSE", "mass": 83938.0, "length": 782, "protein_name": "Transcription factor SOX-30", "gene_name": "Sox30", "organism": "Mouse", "refseq_name": "transcription factor SOX-30", "refseq_ac": "NP_775560", "gene_names_uniprotkb": "Sox30", "gene_names_refseq": "Sox30", "protein_names_uniprotkb": "Transcription factor SOX-30", "protein_names_refseq": "SRY-box containing gene 30; transcription factor SOX-30", "tax_id": 10090, "disease": "lung cancer (Disease Ontology:DOID:1324); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:214105)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10359848;25609838;29739711;29848638;29866902;33721419", "class_list": "", "function": "Acts both as a transcriptional activator and a repressor (PubMed:29848638, PubMed:29866902). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:29866902). Binds to its own promoter and activates its own transcription (PubMed:29848638, PubMed:29866902). Required to activate the expression of postmeiotic genes involved in spermiogenesis (PubMed:29848638, PubMed:29866902). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Identification of SRY-box 30 as an age-related essential gatekeeper for male germ-cell meiosis and differentiation. Erratum:[Aging Cell. 2022 Nov;21(11):e13728. doi: 10.1111/acel.13728. PMID: 36205919], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010369 chromocenter", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CGW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2U0-1", "uniprot_id": "SEH1_MOUSE", "mass": 39775.0, "length": 360, "protein_name": "Nucleoporin SEH1", "gene_name": "Seh1l", "organism": "Mouse", "refseq_name": "nucleoporin SEH1 isoform a", "refseq_ac": "NP_001034177", "gene_names_uniprotkb": "Seh1l", "gene_names_refseq": "2610007A16Rik; SEC13L; SEH1A; SEH1B; Seh1l; Seh1", "protein_names_uniprotkb": "Nucleoporin SEH1; GATOR2 complex protein SEH1; Nup107-160 subcomplex subunit SEH1", "protein_names_refseq": "GATOR complex protein SEH1; GATOR2 complex protein SEH1; nucleoporin SEH1 isoform a; nucleoporin SEH1; nup107-160 subcomplex subunit SEH1; sec13-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:72124); (R-MMU-141430); (R-MMU-141444); (R-MMU-159227); (R-MMU-159230); (R-MMU-159231); (R-MMU-159236); (R-MMU-170822); (R-MMU-1855170); (R-MMU-1855196); (R-MMU-1855229); (R-MMU-191859); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3108214); (R-MMU-3232142); (R-MMU-3301854); (R-MMU-3371453); (R-MMU-4085377); (R-MMU-4551638); (R-MMU-4570464); (R-MMU-4615885); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9615933); (R-MMU-9639288); (R-MMU-9648025)", "pathway_count": 27, "publication_count": 9, "publication_id_list": "20824097;25605945;30084848;30779550;30876848;31219806;34428180;37453065;38272027", "class_list": "", "function": "As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex., [UniProtKB, UniProtKB]; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore., [UniProtKB, UniProtKB]; Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells., [RefSeq, PubMed]; Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis., [RefSeq, PubMed]; Results reveal that Seh1 is required for oligodendrocyte differentiation and myelination by promoting assembly of an Olig2-dependent transcription complex., [RefSeq, PubMed]; Seh1l expression is associated with susceptibility to Staphylococcus aureus sepsis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLC9;Q3UP79;Q9D0K7", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005765 lysosomal membrane;GO:0000776 kinetochore;GO:0061700 GATOR2 complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R2U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4L0-1", "uniprot_id": "SLAP2_MOUSE", "mass": 28476.0, "length": 259, "protein_name": "Src-like-adapter 2", "gene_name": "Sla2", "organism": "Mouse", "refseq_name": "src-like-adapter 2", "refseq_ac": "NP_084259", "gene_names_uniprotkb": "Sla2", "gene_names_refseq": "A930009E21Rik; SLAP-2; SLAP2; Sla2", "protein_names_uniprotkb": "Src-like-adapter 2; SLAP-2; Src-like adapter protein 2", "protein_names_refseq": "modulator of antigen receptor signaling MARS; src-like adapter protein 2; src-like-adapter 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:77799); (R-MMU-9706369)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11891219;12024036;17353186;21220694;25301707;27458164;33620036", "class_list": "", "function": "Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins., [UniProtKB, PubMed, PubMed]; In bone marrow-derived dendritic cells lacking SLAP and closely related SLAP2, downregulation of the granulocyte-macrophage colony-stimulating factor (GM-CSF)beta receptor is impaired., [RefSeq, PubMed]; SLAP and SLAP2 are critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke, [RefSeq, PubMed]; SLAP-2 plays a role in c-Cbl-dependent down-regulation of CSF-1R signaling, [RefSeq, PubMed]; SLAP2 acts as a negative regulator of FLT3 signaling and therefore, modulation of SLAP2 expression levels may provide an alternative therapeutic approach for FLT3-ITD positive acute myeloid leukemia, [RefSeq, PubMed]; Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL-SLAP2 crystal complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UU74;Q8C0K2;Q8VI42;Q9D1Z9", "ec_number_list": "", "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0005770 late endosome", "go_biological_process": "GO:0050849 negative regulation of calcium-mediated signaling;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0042110 T cell activation;GO:0002250 adaptive immune response;GO:0050860 negative regulation of T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R4L0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE18-1", "uniprot_id": "SMG8_MOUSE", "mass": 109667.0, "length": 991, "protein_name": "Nonsense-mediated mRNA decay factor SMG8", "gene_name": "Smg8", "organism": "Mouse", "refseq_name": "nonsense-mediated mRNA decay factor SMG8", "refseq_ac": "NP_077224", "gene_names_uniprotkb": "Smg8", "gene_names_refseq": "1200011M11Rik; Smg8", "protein_names_uniprotkb": "Nonsense-mediated mRNA decay factor SMG8; Protein smg-8 homolog", "protein_names_refseq": "CG6729 gene product; nonsense-mediated mRNA decay factor SMG8; protein SMG8; protein smg-8 homolog; smg-8 homolog, nonsense mediated mRNA decay factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:74133); (R-MMU-975957)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21952136;24129315;25605945;31219806;34428180", "class_list": "", "function": "Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9290, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2KGQ4;Q8BS62;Q8BSP7;Q9DBW6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045859 regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VE18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q920G3-1", "uniprot_id": "SIGL5_MOUSE", "mass": 61476.0, "length": 569, "protein_name": "Sialic acid-binding Ig-like lectin 5", "gene_name": "Siglec5", "organism": "Mouse", "refseq_name": "sialic acid-binding Ig-like lectin 5 isoform 2 precursor", "refseq_ac": "NP_001257948", "gene_names_uniprotkb": "Siglec5; Siglecf", "gene_names_refseq": "Siglec5; Siglecf; mSiglec-F", "protein_names_uniprotkb": "Sialic acid-binding Ig-like lectin 5; Sialic acid-binding Ig-like lectin F; Siglec-5; Siglec-F; mSiglec-F", "protein_names_refseq": "sialic acid-binding Ig-like lectin 5 isoform 2 precursor; sialic acid-binding Ig-like lectin 5; sialic acid-binding lectin Siglec-F; siglec-5; siglec-F", "tax_id": 10090, "disease": "", "pathway": " (mmu:233186); (R-MMU-198933); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11579105;14559209;17272508;35482420;37251384", "class_list": "glycogene", "function": "Induction of Siglec-F[hi]CD101[hi] eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection. Publication Status: Online-Only, [RefSeq, PubMed]; Negative feedback role for Siglec-F in regulating the pathogenesis of human eosinophil-mediated disorders., [RefSeq, PubMed]; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface., [UniProtKB]; Siglec-F-expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis., [RefSeq, PubMed]; We detected expression of mSiglec-5 (or -F), -10, and -E mRNA in purified mouse eosinophils, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 52, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0033691 sialic acid binding;GO:0048029 monosaccharide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0007155 cell adhesion;GO:0030100 regulation of endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q920G3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J19-1", "uniprot_id": "SIM11_MOUSE", "mass": 6345.0, "length": 55, "protein_name": "Small integral membrane protein 11", "gene_name": "Smim11", "organism": "Mouse", "refseq_name": "small integral membrane protein 11", "refseq_ac": "NP_620082", "gene_names_uniprotkb": "Smim11; Fam165b; Smim11a", "gene_names_refseq": "1190017O12Rik; C21orf51; Fam165b; Smim11a; Smim11", "protein_names_uniprotkb": "Small integral membrane protein 11", "protein_names_refseq": "family with sequence similarity 165, member B; protein FAM165B; small integral membrane protein 11A; small integral membrane protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:68936)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11707072", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99J19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CX34-1", "uniprot_id": "SGT1_MOUSE", "mass": 38159.0, "length": 336, "protein_name": "Protein SGT1 homolog", "gene_name": "Sugt1", "organism": "Mouse", "refseq_name": "protein SGT1 homolog", "refseq_ac": "NP_080750", "gene_names_uniprotkb": "Sugt1", "gene_names_refseq": "2410174K12Rik; SGT1; Sugt1", "protein_names_uniprotkb": "Protein SGT1 homolog; Suppressor of G2 allele of SKP1 homolog", "protein_names_refseq": "protein SGT1 homolog; suppressor of G2 allele of SKP1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67955); (R-MMU-844456)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "23184943;31219806;32483152;34428180;37317573;39927985", "class_list": "", "function": "Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner, [RefSeq, PubMed]; Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB]; MiR-141-3p alleviates ulcerative colitis by targeting SUGT1 to inhibit colonic epithelial cell pyroptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UF88;Q9CRE7;Q9D8M6", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0031647 regulation of protein stability;GO:0007051 spindle organization;GO:0014841 skeletal muscle satellite cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CX34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXB2-1", "uniprot_id": "SOAT_MOUSE", "mass": 40681.0, "length": 373, "protein_name": "Sodium-dependent organic anion transporter", "gene_name": "Slc10a6", "organism": "Mouse", "refseq_name": "sodium-dependent organic anion transporter", "refseq_ac": "NP_083691", "gene_names_uniprotkb": "Slc10a6; Soat", "gene_names_refseq": "8430417G17Rik; Slc10a6; Soat", "protein_names_uniprotkb": "Sodium-dependent organic anion transporter; SLC10A6; SOAT; Solute carrier family 10 member 6", "protein_names_refseq": "sodium-dependent organic anion transporter; solute carrier family 10 member 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:75750); (R-MMU-9958517)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23562556;28743544", "class_list": "", "function": "Slc10a6 role in the supply of steroids in the testis and consequently for spermatogenesis and fertility., [RefSeq, PubMed]; Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis (PubMed:23562556). Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids (By similarity). May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs (PubMed:23562556). May play a role transporting the estriol precursor 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium (By similarity). Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RTH4", "ec_number_list": "", "go_molecular_function": "GO:0008508 bile acid:sodium symporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0043251 sodium-dependent organic anion transport;GO:0015721 bile acid and bile salt transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CXB2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3G2-1", "uniprot_id": "SLAF8_MOUSE", "mass": 30646.0, "length": 278, "protein_name": "SLAM family member 8", "gene_name": "Slamf8", "organism": "Mouse", "refseq_name": "SLAM family member 8 precursor", "refseq_ac": "NP_083360", "gene_names_uniprotkb": "Slamf8; Blame", "gene_names_refseq": "5830408F06Rik; Blame; SBBI42; Slamf8", "protein_names_uniprotkb": "SLAM family member 8; B-lymphocyte activator macrophage expressed", "protein_names_refseq": "B lymphocyte activator macrophage expressed; SLAM family member 8 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:74748)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11313408;22593622;25799045;30552382;35259711;35837407", "class_list": "", "function": "Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages., [RefSeq, PubMed]; Knockout of SLAMF8 attenuates collagen-induced rheumatoid arthritis in mice through inhibiting TLR4/NF-kappaB signaling pathway., [RefSeq, PubMed]; May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor., [UniProtKB, PubMed]; SLAMF8 Downregulates Mouse Macrophage Microbicidal Mechanisms via PI3K Pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Slamf1 and Slamf8 govern ROS-dependent innate immune responses of myeloid cells. Publication Status: Online-Only, [RefSeq, PubMed]; Slamf8 was found to be a negative regulator of Nox2 activity in bacterial phagosomes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3T7", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0090027 negative regulation of monocyte chemotaxis;GO:0090383 phagosome acidification;GO:0006955 immune response;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D3G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7P9-1", "uniprot_id": "SPB12_MOUSE", "mass": 47835.0, "length": 423, "protein_name": "Serpin B12", "gene_name": "Serpinb12", "organism": "Mouse", "refseq_name": "serpin B12", "refseq_ac": "NP_001186142", "gene_names_uniprotkb": "Serpinb12", "gene_names_refseq": "2300003F07Rik; 4833409F13Rik; Serpinb12", "protein_names_uniprotkb": "Serpin B12", "protein_names_refseq": "serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12; serpin B12", "tax_id": 10090, "disease": "", "pathway": " (mmu:71869); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15203215;26220980;35820727", "class_list": "", "function": "Data suggest that SERPINB12, like some other intracellular serpins, may play a vital role in barrier function by providing protection of epithelial cells., [RefSeq, PubMed]; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator. May play a role in cell differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6UKZ3", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0001533 cornified envelope", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7P9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAH1-1", "uniprot_id": "SCP2D_MOUSE", "mass": 17371.0, "length": 156, "protein_name": "SCP2 sterol-binding domain-containing protein 1", "gene_name": "Scp2d1", "organism": "Mouse", "refseq_name": "SCP2 sterol-binding domain-containing protein 1", "refseq_ac": "NP_079766", "gene_names_uniprotkb": "Scp2d1", "gene_names_refseq": "1700010M22Rik; Scp2d1", "protein_names_uniprotkb": "SCP2 sterol-binding domain-containing protein 1", "protein_names_refseq": "SCP2 sterol-binding domain-containing protein 1; likely ortholog of H. sapiens chromosome 20 open reading frame 79 (C20orf79)", "tax_id": 10090, "disease": "", "pathway": " (mmu:66328)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RL24", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DAH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBC0-1", "uniprot_id": "SELO_MOUSE", "mass": 74221.0, "length": 667, "protein_name": "Protein adenylyltransferase SelO, mitochondrial", "gene_name": "Selenoo", "organism": "Mouse", "refseq_name": "protein adenylyltransferase SelO, mitochondrial", "refseq_ac": "NP_082181", "gene_names_uniprotkb": "Selenoo; Selo", "gene_names_refseq": "1300018J18Rik; Selenoo; Selo", "protein_names_uniprotkb": "Protein adenylyltransferase SelO, mitochondrial; 2.7.7.-; 2.7.7.108; SelO; Selenoprotein O", "protein_names_refseq": "protein adenylyltransferase SelO, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:223776)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein., [UniProtKB, UniProtKB]; This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Jan 2017]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QPP4;Q80ZK3", "ec_number_list": "3.1.4.-;2.7.7.108;2.7.7.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0070733 AMPylase activity;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005694 chromosome", "go_biological_process": "GO:0018117 protein adenylylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DBC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESP1-1", "uniprot_id": "SDF2L_MOUSE", "mass": 23648.0, "length": 221, "protein_name": "Stromal cell-derived factor 2-like protein 1", "gene_name": "Sdf2l1", "organism": "Mouse", "refseq_name": "stromal cell-derived factor 2-like protein 1 precursor", "refseq_ac": "NP_071719", "gene_names_uniprotkb": "Sdf2l1", "gene_names_refseq": "Sdf2l1", "protein_names_uniprotkb": "Stromal cell-derived factor 2-like protein 1; SDF2-like protein 1", "protein_names_refseq": "SDF2-like protein 1; stromal cell-derived factor 2-like protein 1 precursor; stromal cell-derived factor 2-like protein 1", "tax_id": 10090, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:64136)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11162531;16479539;25428506;26740625;27802388;30084848;30814508;34428180", "class_list": "", "function": "In obese and diabetic mice, Sdf2l1 is downregulated due to decreased levels of nuclear XBP-1s, whereas restoration of Sdf2l1 expression ameliorates glucose intolerance and fatty liver with decreased ER stress. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESP2", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0051117 ATPase binding;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0042981 regulation of apoptotic process;GO:0036503 ERAD pathway;GO:0034976 response to endoplasmic reticulum stress;GO:0042026 protein refolding;GO:0071218 cellular response to misfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ESP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHX2-1", "uniprot_id": "SP5_MOUSE", "mass": 42052.0, "length": 398, "protein_name": "Transcription factor Sp5", "gene_name": "Sp5", "organism": "Mouse", "refseq_name": "transcription factor Sp5", "refseq_ac": "NP_071880", "gene_names_uniprotkb": "Sp5", "gene_names_refseq": "Sp5", "protein_names_uniprotkb": "Transcription factor Sp5", "protein_names_refseq": "transcription factor Sp5", "tax_id": 10090, "disease": "", "pathway": " (mmu:64406)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11071760", "class_list": "", "function": "Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149T2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0060349 bone morphogenesis;GO:0036342 post-anal tail morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JHX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJN4-1", "uniprot_id": "SCO2A_MOUSE", "mass": 56473.0, "length": 520, "protein_name": "Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial", "gene_name": "Oxct2a", "organism": "Mouse", "refseq_name": "succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial precursor", "refseq_ac": "NP_071316", "gene_names_uniprotkb": "Oxct2a", "gene_names_refseq": "Oxct2a; Oxct2; Oxct; Scot-t1; Scot", "protein_names_uniprotkb": "Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; 2.8.3.5; 3-oxoacid CoA-transferase 2A; SCOT-t1; Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1", "protein_names_refseq": "haploid germ cell specific succinyl CoA transferase; succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial precursor; succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; succinyl-CoA:3-oxoacid CoA-transferase; testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:64059); (R-MMU-77108)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12534938;15028287;20527992;38242911", "class_list": "", "function": "AMPKalpha2 regulates fasting-induced hyperketonemia by suppressing SCOT ubiquitination and degradation. Publication Status: Online-Only, [RefSeq, PubMed]; Germ cells and somatic cells differentially express the SCOT enzymes and that the SCOT activity of sperm caused exclusively by SCOT-t should play an important role in sperm activity., [RefSeq, PubMed]; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa., [UniProtKB]; Oxct2a and Oxct2b are testicular haploid germ cell-specific genes, [RefSeq, PubMed]; Two tyrosine residues of SCOT are the priority sites attacked by nitric oxide, and their nitration status is a causal factor leading to inhibition of SCOT catalysis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EHG5", "ec_number_list": "2.8.3.5", "go_molecular_function": "GO:0008260 succinyl-CoA:3-oxo-acid CoA-transferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006104 succinyl-CoA metabolic process;GO:0046952 ketone body catabolic process;GO:1902224 ketone body metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JJN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJU8-1", "uniprot_id": "SH3L1_MOUSE", "mass": 12811.0, "length": 114, "protein_name": "Adapter Sh3bgrl", "gene_name": "Sh3bgrl", "organism": "Mouse", "refseq_name": "adapter Sh3bgrl", "refseq_ac": "NP_064373", "gene_names_uniprotkb": "Sh3bgrl", "gene_names_refseq": "1190008F14Rik; Sh3bgrl", "protein_names_uniprotkb": "Adapter Sh3bgrl; SH3 domain-binding glutamic acid-rich-like protein 1", "protein_names_refseq": "SH3 domain-binding glutamic acid-rich-like protein 1; SH3 domain-binding glutamic acid-rich-like protein; adapter Sh3bgrl", "tax_id": 10090, "disease": "", "pathway": " (mmu:56726)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20173027;25428506;26495903;28528544;30084848;30779550;37507081", "class_list": "", "function": "Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ALN7;Q3UB57", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0140517 protein-RNA adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:1904690 positive regulation of cytoplasmic translational initiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JJU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64302-1", "uniprot_id": "T4S1_MOUSE", "mass": 22243.0, "length": 202, "protein_name": "Transmembrane 4 L6 family member 1", "gene_name": "Tm4sf1", "organism": "Mouse", "refseq_name": "transmembrane 4 L6 family member 1 isoform 1", "refseq_ac": "NP_032562", "gene_names_uniprotkb": "Tm4sf1; M3s1", "gene_names_refseq": "L6; M3s1; Tm4sf1", "protein_names_uniprotkb": "Transmembrane 4 L6 family member 1; Membrane component chromosome 3 surface marker 1 homolog; Tumor-associated antigen L6", "protein_names_refseq": "12A8 target antigen; L6 antigen; membrane component chromosome 3 surface marker 1 homolog; membrane component, surface marker 1; transmembrane 4 L6 family member 1 isoform 1; transmembrane 4 L6 family member 1; tumor-associated antigen L6", "tax_id": 10090, "disease": "", "pathway": " (mmu:17112)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12855661;19656770;21750661;7510285", "class_list": "", "function": "TAL6 may play a role in cancer invasion and metastasis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP49", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001825 blastocyst formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q64302-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQA7-1", "uniprot_id": "TA2R3_MOUSE", "mass": 36289.0, "length": 316, "protein_name": "Taste receptor type 2 member 3", "gene_name": "Tas2r137; Tas2r3", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 3", "refseq_ac": "NP_001020556", "gene_names_uniprotkb": "Tas2r137; Tas2r3; T2r41; Tas2r137; Tas2r37", "gene_names_refseq": "T2R37; Tas2r137; Tas2r3; mt2r41", "protein_names_uniprotkb": "Taste receptor type 2 member 3; T2R137; T2R37; T2R3; mT2r41", "protein_names_refseq": "T2R137; candidate taste receptor mt2r41; taste receptor T2R37; taste receptor type 2 member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:574417); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "12679530;12734386;21750661", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7M727", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TQA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UZP4-1", "uniprot_id": "SVIP_MOUSE", "mass": 8364.0, "length": 77, "protein_name": "Small VCP/p97-interacting protein", "gene_name": "Svip", "organism": "Mouse", "refseq_name": "small VCP/p97-interacting protein", "refseq_ac": "NP_001153817", "gene_names_uniprotkb": "Svip", "gene_names_refseq": "1700006C13Rik; 6620401M08Rik; Svip", "protein_names_uniprotkb": "Small VCP/p97-interacting protein", "protein_names_refseq": "small VCP/p97-interacting protein", "tax_id": 10090, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (mmu:75744); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;21909394;24055875;35042898", "class_list": "", "function": "Negative regulator of the ER-associated degradation pathway (ERAD) of misfolded proteins. It competes with AMFR/gp78 for binding VCP/p97, and inhibits AMFR/gp78-VCP/p97 complex formation that is required for degradation of ERAD substrates. Involved in the regulation of adrenal cortisol and dehydroepiandrosterone (DHEA) biosynthesis., [UniProtKB, UniProtKB]; SVIP and valosin containing protein were seen to be co-localized in neuronal cell bodies., [RefSeq, PubMed]; SVIP plays a regulatory role in p97 subcellular localization and is a novel regulator of autophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010508 positive regulation of autophagy;GO:0031333 negative regulation of protein-containing complex assembly;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process;GO:1904240 negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly;GO:1904153 negative regulation of retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UZP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UB74-1", "uniprot_id": "TBRG1_MOUSE", "mass": 44881.0, "length": 406, "protein_name": "Transforming growth factor beta regulator 1", "gene_name": "Tbrg1", "organism": "Mouse", "refseq_name": "transforming growth factor beta regulator 1", "refseq_ac": "NP_079565", "gene_names_uniprotkb": "Tbrg1; Niam", "gene_names_refseq": "Niam; Tb-5; Tbrg1; mFLJ00213", "protein_names_uniprotkb": "Transforming growth factor beta regulator 1; Nuclear interactor of ARF and Mdm2", "protein_names_refseq": "nuclear interactor of ARF and Mdm2; transforming growth factor beta regulator 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:21376)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17110379;17242355;21750661;25393878;25605945;28811661;30084848;31219806;31599954;34428180;7654366", "class_list": "", "function": "Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability., [UniProtKB, PubMed]; NIAM down-regulation in vivo results in a significant predisposition to developing benign tumors or early stage cancers. Publication Status: Online-Only, [RefSeq, PubMed]; Novel protein with tumor suppressor-like behaviors and functional links to ARF-MDM2-p53 signaling, [RefSeq, PubMed]; The data provides a useful resource for exploring Myst2 and Niam essential cellular functions and should contribute to deeper understanding of organism early development and survival as well as cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLE7;Q3UCG2;Q3YBR3;Q6P067;Q80XA1;Q8CGC5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1990173 protein localization to nucleoplasm;GO:0008285 negative regulation of cell population proliferation;GO:0006260 DNA replication;GO:0050821 protein stabilization;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3UB74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P86050-1", "uniprot_id": "T170B_MOUSE", "mass": 14416.0, "length": 132, "protein_name": "Transmembrane protein 170B", "gene_name": "Tmem170b", "organism": "Mouse", "refseq_name": "transmembrane protein 170B isoform 1", "refseq_ac": "NP_001157044", "gene_names_uniprotkb": "Tmem170b", "gene_names_refseq": "EG621976; Tmem170b", "protein_names_uniprotkb": "Transmembrane protein 170B", "protein_names_refseq": "transmembrane protein 170B isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:621976)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P86050-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ANU3-1", "uniprot_id": "SYNG1_MOUSE", "mass": 28456.0, "length": 258, "protein_name": "Synapse differentiation-inducing gene protein 1", "gene_name": "Syndig1", "organism": "Mouse", "refseq_name": "synapse differentiation-inducing gene protein 1 isoform 1", "refseq_ac": "NP_001078990", "gene_names_uniprotkb": "Syndig1; Tmem90b", "gene_names_refseq": "DSPC2; Gm14134; H2C20orf39; Syndig1; Tmem90b", "protein_names_uniprotkb": "Synapse differentiation-inducing gene protein 1; DSPC2; Dispanin subfamily C member 2; SynDIG1; Transmembrane protein 90B", "protein_names_refseq": "dispanin subfamily C member 2; synapse differentiation-inducing gene protein 1 isoform 1; synapse differentiation-inducing gene protein 1; transmembrane protein 90B", "tax_id": 10090, "disease": "", "pathway": " (mmu:433485)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12408845;20152115;21750661;22363774;27445135;27800545;35500677", "class_list": "", "function": "May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation., [UniProtKB]; Mice with reduced SynDIG1 exhibit deficits in the structure and function of excitatory synapses. Mature synapses are still present, albeit at a significantly reduced number, suggesting that synapses can reach maturity without SynDIG1. However, the overall reduction in the number of mature synapses by multiple criteria suggests that SynDIG1 is important for normal development. Publication Status: Online-Only, [RefSeq, PubMed]; Synapse differentiation-induced gene 1 regulates stress-induced depression through interaction with the AMPA receptor GluA2 subunit of nucleus accumbens in male mice., [RefSeq, PubMed]; This study provides mechanistic insight into SynDIG1 structure and function to demonstrate that its stability and subcellular localization are regulated by activity-dependent palmitoylation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0035254 glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0043198 dendritic shaft", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0006886 intracellular protein transport;GO:0051965 positive regulation of synapse assembly;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A2ANU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NZA9-1", "uniprot_id": "TAF9B_MOUSE", "mass": 27172.0, "length": 249, "protein_name": "Transcription initiation factor TFIID subunit 9B", "gene_name": "Taf9b", "organism": "Mouse", "refseq_name": "transcription initiation factor TFIID subunit 9B isoform 2", "refseq_ac": "NP_001001176", "gene_names_uniprotkb": "Taf9b; Taf9l", "gene_names_refseq": "Taf9b; Taf9l", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 9B; Transcription initiation factor TFIID subunit 9-like; Transcription-associated factor TAFII31L", "protein_names_refseq": "TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor; transcription initiation factor TFIID subunit 9B isoform 2; transcription initiation factor TFIID subunit 9B; transcription-associated factor TAFII31L", "tax_id": 10090, "disease": "", "pathway": " (mmu:407786); (R-MMU-5689880); (R-MMU-674695); (R-MMU-6804756); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "17242355;21576927;21750661;25006164;36852467;40885482", "class_list": "", "function": "Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity)., [UniProtKB]; TAF9B also regulates neuronal gene transcription in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; These observations suggest that although CINAP deletion in mice does not influence learning and memory behaviors, CINAP is required for restriction of locomotor and exploratory activities., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AP80;Q3UXZ3;Q3V2M4;Q80WW6", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005669 transcription factor TFIID complex;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030307 positive regulation of cell growth;GO:0043066 negative regulation of apoptotic process;GO:0050821 protein stabilization;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6NZA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AQ07-1", "uniprot_id": "TBB1_MOUSE", "mass": 50441.0, "length": 451, "protein_name": "Tubulin beta-1 chain", "gene_name": "Tubb1", "organism": "Mouse", "refseq_name": "tubulin beta-1 chain", "refseq_ac": "NP_001074440", "gene_names_uniprotkb": "Tubb1", "gene_names_refseq": "2810484G07Rik; M(beta)1; Tubb1", "protein_names_uniprotkb": "Tubulin beta-1 chain", "protein_names_refseq": "tubulin beta-1 chain", "tax_id": 10090, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); autosomal dominant isolated macrothrombocytopenia 1 (Disease Ontology:DOID:0090102); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); tubulinopathy (Disease Ontology:DOID:0112227); facial paralysis (Disease Ontology:DOID:13934); hypokalemic periodic paralysis (Disease Ontology:DOID:14452)", "pathway": " (mmu:545486); (R-MMU-190840); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3371497); (R-MMU-380320); (R-MMU-437239); (R-MMU-5610787); (R-MMU-5620920); (R-MMU-5620924); (R-MMU-5626467); (R-MMU-5663220); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811436); (R-MMU-68877); (R-MMU-8852276); (R-MMU-8955332); (R-MMU-9646399); (R-MMU-9648025); (R-MMU-9668328); (R-MMU-983189); (R-MMU-9833482)", "pathway_count": 24, "publication_count": 13, "publication_id_list": "12586623;15890843;17242355;18347012;19524510;21183079;23897886;25605945;26495903;26740625;30446499;33414192;34428180", "class_list": "", "function": "Findings highlight the essential requirements of the megakaryocyte/platelet-restricted beta1-tubulin isoform in platelet structure, [RefSeq, PubMed]; In mice, Tubb1 knock-out disrupted microtubule integrity by preventing beta1-tubulin incorporation and impaired thyroid migration and thyroid hormone secretion., [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge", "go_biological_process": "GO:0030878 thyroid gland development;GO:0046785 microtubule polymerization;GO:0000278 mitotic cell cycle;GO:0070527 platelet aggregation;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A2AQ07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3KGB4-1", "uniprot_id": "TBC8B_MOUSE", "mass": 127893.0, "length": 1114, "protein_name": "TBC1 domain family member 8B", "gene_name": "Tbc1d8b", "organism": "Mouse", "refseq_name": "TBC1 domain family member 8B", "refseq_ac": "NP_001074968", "gene_names_uniprotkb": "Tbc1d8b", "gene_names_refseq": "4921505D17Rik; 9030605E16Rik; Tbc1d8b", "protein_names_uniprotkb": "TBC1 domain family member 8B", "protein_names_refseq": "TBC1 domain family member 8B", "tax_id": 10090, "disease": "nephrotic syndrome type 20 (Disease Ontology:DOID:0070357)", "pathway": " (mmu:245638); (R-MMU-432722)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "34428180;37828378", "class_list": "", "function": "Involved in vesicular recycling, probably as a RAB11B GTPase-activating protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJW4", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0003094 glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A3KGB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YS9-1", "uniprot_id": "STKL1_MOUSE", "mass": 74843.0, "length": 662, "protein_name": "Serine/threonine kinase-like domain-containing protein STKLD1", "gene_name": "Stkld1", "organism": "Mouse", "refseq_name": "serine/threonine kinase-like domain-containing protein STKLD1 isoform 2", "refseq_ac": "NP_941030", "gene_names_uniprotkb": "Stkld1; Gm711; Sgk071", "gene_names_refseq": "Gm711; Sgk071; Stkld1", "protein_names_uniprotkb": "Serine/threonine kinase-like domain-containing protein STKLD1; Serine/threonine kinase-like domain-containing protein 1; Sugen kinase 071", "protein_names_refseq": "likely ortholog of H. sapiens chromosome 9 open reading frame 96 (C9orf96); probable inactive protein kinase-like protein SgK071 homolog; probable protein kinase-like protein SgK071 homolog; serine/threonine kinase-like domain-containing protein 1; serine/threonine kinase-like domain-containing protein STKLD1 isoform 2; serine/threonine kinase-like domain-containing protein STKLD1; sugen kinase 071", "tax_id": 10090, "disease": "", "pathway": " (mmu:279029)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25605945", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ALB0", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004672 protein kinase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80YS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYA0-1", "uniprot_id": "TBCD_MOUSE", "mass": 133321.0, "length": 1196, "protein_name": "Tubulin-specific chaperone D", "gene_name": "Tbcd", "organism": "Mouse", "refseq_name": "tubulin-specific chaperone D", "refseq_ac": "NP_084154", "gene_names_uniprotkb": "Tbcd", "gene_names_refseq": "2310057L06Rik; A030005L14Rik; Tbcd; mKIAA0988", "protein_names_uniprotkb": "Tubulin-specific chaperone D; Beta-tubulin cofactor D; Tubulin-folding cofactor D", "protein_names_refseq": "beta-tubulin cofactor D; tubulin-folding cofactor D; tubulin-specific chaperone D", "tax_id": 10090, "disease": "early onset progressive encephalopathy with brain atrophy and thin corpus callosum (Disease Ontology:DOID:0070423)", "pathway": " (mmu:108903)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;39627609", "class_list": "", "function": "Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006457 protein folding;GO:0070830 bicellular tight junction assembly;GO:0000226 microtubule cytoskeleton organization;GO:0010812 negative regulation of cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BYA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AUS7-1", "uniprot_id": "SSXA1_MOUSE", "mass": 11929.0, "length": 101, "protein_name": "Protein SSXA1", "gene_name": "Ssxa1", "organism": "Mouse", "refseq_name": "protein SSXA1", "refseq_ac": "NP_001192015", "gene_names_uniprotkb": "Ssxa1; Ssxa", "gene_names_refseq": "Gm1532; Ssxa1; Ssxa", "protein_names_uniprotkb": "Protein SSXA1; Synovial sarcoma, X member A1", "protein_names_refseq": "protein SSXA1; synovial sarcoma, X member A, breakpoint 1; synovial sarcoma, X member A1", "tax_id": 10090, "disease": "X-linked spermatogenic failure 5 (Disease Ontology:DOID:0070596); synovial sarcoma (Disease Ontology:DOID:5485)", "pathway": " (mmu:385338)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21725589;21750661", "class_list": "", "function": "Could act as a modulator of transcription., [UniProtKB]; Data conclude that the N-terminal cleaved fragment of Ssxa, which has a KRAB domain (nuclear localization signal), translocates into the nucleus after cleavage of the C-terminus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9RK38", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0036126 sperm flagellum", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B1AUS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JL10-1", "uniprot_id": "SRTD1_MOUSE", "mass": 25136.0, "length": 236, "protein_name": "SERTA domain-containing protein 1", "gene_name": "Sertad1", "organism": "Mouse", "refseq_name": "SERTA domain-containing protein 1", "refseq_ac": "NP_061290", "gene_names_uniprotkb": "Sertad1; Sei1", "gene_names_refseq": "1110032C13Rik; Sei-1; Sei1; Sertad1; TRIP-Br1", "protein_names_uniprotkb": "SERTA domain-containing protein 1; CDK4-binding protein p34SEI1; SEI-1; TRIP-Br1; Transcriptional regulator interacting with the PHD-bromodomain 1", "protein_names_refseq": "CDK4-binding protein p34SEI1; PHD zinc finger- and bromodomain-interacting protein 1; SERTA domain-containing protein 1; p34SEI-1; transcriptional regulator interacting with the PHD-bromodomain 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:55942)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11331592;20090907;20237268;21750661;29497033;34428180;35710446;38341852", "class_list": "", "function": "Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A., [UniProtKB, PubMed]; Conclude that Sei1 plays an important role in pancreatic beta-cells, which supports a functional link between Sei1 and the core cell cycle regulators specifically in the context of the pancreas Publication Status: Online-Only, [RefSeq, PubMed]; SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination., [RefSeq, PubMed]; Sei-1 promotes double minute chromosomes formation with increasing passage number. Publication Status: Online-Only, [RefSeq, PubMed]; Sertad1 expression is required is required for developmental neuronal death in the cerebral cortex., [RefSeq, PubMed]; The regulation of insulin receptor/insulin-like growth factor 1 receptor ratio, an important factor for breast cancer prognosis, by TRIP-Br1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q925E6;Q9D888", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JL10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8Y1-1", "uniprot_id": "T126A_MOUSE", "mass": 21539.0, "length": 196, "protein_name": "Transmembrane protein 126A", "gene_name": "Tmem126a", "organism": "Mouse", "refseq_name": "transmembrane protein 126A", "refseq_ac": "NP_079736", "gene_names_uniprotkb": "Tmem126a", "gene_names_refseq": "1810020E01Rik; Tmem126a", "protein_names_uniprotkb": "Transmembrane protein 126A", "protein_names_refseq": "transmembrane protein 126A", "tax_id": 10090, "disease": "optic atrophy 7 (Disease Ontology:DOID:0111437)", "pathway": " (mmu:66271)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19327736;21750661;22885069;25549946;30779550;31219806;34428180;37507081", "class_list": "", "function": "Protein required for the cotranslational protein quality control in the inner membrane of the mitochondria. Associates with newly synthesized polypeptides and may act as a chaperone that cooperates with OXA1L for the insertion of newly synthesized mitochondrial proteins into the inner membrane. Required for the assembly of the ND4 module of mitochondrial complex I., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TMEM126A binds to the extracellular domain of CD137L and is detected on cell surface by flow cytometry, cell surface expression of TMEM126A may be essential for CD137L reverse signaling., [RefSeq, PubMed]; TMEM126A contributes to the TLR4 signal up-regulating the expression of genes whose products are involved in antigen presentation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0021554 optic nerve development;GO:0034142 toll-like receptor 4 signaling pathway;GO:0032979 protein insertion into mitochondrial inner membrane from matrix;GO:0141164 mitochondrial protein quality control", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D8Y1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LM9-1", "uniprot_id": "TADA1_MOUSE", "mass": 37409.0, "length": 335, "protein_name": "Transcriptional adapter 1", "gene_name": "Tada1", "organism": "Mouse", "refseq_name": "transcriptional adapter 1", "refseq_ac": "NP_084521", "gene_names_uniprotkb": "Tada1; Tada1l", "gene_names_refseq": "2900026B15Rik; D1Ertd251e; Staf42; Tada1l; Tada1", "protein_names_uniprotkb": "Transcriptional adapter 1; Transcriptional adapter 1-like protein", "protein_names_refseq": "transcriptional adapter 1-like protein; transcriptional adapter 1; transcriptional adaptor 1 (HFI1 homolog, yeast) like", "tax_id": 10090, "disease": "", "pathway": " (mmu:27878)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20173027;21750661;25428506;28135057;30084848;30779550;34428180", "class_list": "", "function": "Probably involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0000124 SAGA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0043484 regulation of RNA splicing;GO:0006282 regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99LM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0CC03-1", "uniprot_id": "ST6B1_MOUSE", "mass": 35077.0, "length": 303, "protein_name": "Sulfotransferase 6B1", "gene_name": "Sult6b1", "organism": "Mouse", "refseq_name": "sulfotransferase 6B1", "refseq_ac": "NP_001157097", "gene_names_uniprotkb": "Sult6b1", "gene_names_refseq": "2410078J06Rik; ST6B1; Sult6b1", "protein_names_uniprotkb": "Sulfotransferase 6B1; 2.8.2.n2; ST6B1; Thyroxine sulfotransferase", "protein_names_refseq": "Thyroxine sulfotransferase; sulfotransferase 6B1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73671); (R-MMU-156584)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19505954;21750661", "class_list": "", "function": "Cloned, expressed and characterized a novel cytosolic SULT6B1; SULT6B1 exhibited sulfonating activity toward thyroxine and bithionol among a variety of endogenous and xenobiotic compounds tested, [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-;2.8.2.n2;2.8.2.4;2.8.2.2;2.8.2.1", "go_molecular_function": "GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0CC03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21958-1", "uniprot_id": "TAP1_MOUSE", "mass": 78864.0, "length": 724, "protein_name": "Antigen peptide transporter 1", "gene_name": "Tap1", "organism": "Mouse", "refseq_name": "antigen peptide transporter 1 isoform 1", "refseq_ac": "NP_038711", "gene_names_uniprotkb": "Tap1; Abcb2; Ham-1; Ham1", "gene_names_refseq": "ABC17; APT1; Abcb2; Ham-1; Ham1; MTP1; PSF1; RING4; TAP; Tap-1; Tap1; Y3", "protein_names_uniprotkb": "Antigen peptide transporter 1; 7.4.2.14; APT1; ATP-binding cassette sub-family B member 2; Histocompatibility antigen modifier 1; Peptide transporter TAP1", "protein_names_refseq": "ABC transporter, MHC, 1; ATP dependent transport protein family member; ATP-binding cassette sub-family B member 2; ATP-binding cassette transporter, major histocompatibility complex, 1; ATP-binding cassette, sub-family B (MDR/TAP), member 2; antigen peptide transporter 1 isoform 1; antigen peptide transporter 1; histocompatibility antigen modifier 1; peptide supply factor 1; peptide transporter PSF1; peptide transporter TAP1; transporter 1 ATP-binding cassette sub-family B; transporter 1, ABC (ATP binding cassette); transporter associated with antigen processing 1; transporter, ABC, MHC, 1; transporter, ATP-binding cassette, major histocompatibility complex, 1", "tax_id": 10090, "disease": "open-angle glaucoma (Disease Ontology:DOID:1067); allergic disease (Disease Ontology:DOID:1205); diffuse scleroderma (Disease Ontology:DOID:1580); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); cervical cancer (Disease Ontology:DOID:4362); rhinitis (Disease Ontology:DOID:4483); schizophrenia (Disease Ontology:DOID:5419); reactive arthritis (Disease Ontology:DOID:6196); ankylosing spondylitis (Disease Ontology:DOID:7147); extrinsic allergic alveolitis (Disease Ontology:DOID:841); psoriasis (Disease Ontology:DOID:8893); bronchiectasis (Disease Ontology:DOID:9563); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:21354); (R-MMU-983170)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;2270487;31219806;34428180;36210013;9164943", "class_list": "", "function": "ABC transporter associated with antigen processing. In complex with TAP2 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules. Uses the chemical energy of ATP to export peptides against the concentration gradient. During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle. As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation., [UniProtKB, UniProtKB]; The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein forms a heterodimer with Tap2 that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62427", "ec_number_list": "7.4.2.14;5.3.4.1", "go_molecular_function": "GO:0046978 TAP1 binding;GO:0046979 TAP2 binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0006952 defense response;GO:0015031 protein transport;GO:0055085 transmembrane transport;GO:0042270 protection from natural killer cell mediated cytotoxicity;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P21958-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YD1-1", "uniprot_id": "SUV3_MOUSE", "mass": 87005.0, "length": 779, "protein_name": "ATP-dependent RNA helicase SUPV3L1, mitochondrial", "gene_name": "Supv3l1", "organism": "Mouse", "refseq_name": "ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 1 precursor", "refseq_ac": "NP_852088", "gene_names_uniprotkb": "Supv3l1; Suv3l1", "gene_names_refseq": "6330443E10Rik; Supv3l1", "protein_names_uniprotkb": "ATP-dependent RNA helicase SUPV3L1, mitochondrial; 3.6.4.13; SUV3-like protein 1; Suppressor of var1 3-like protein 1", "protein_names_refseq": "ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 1 precursor; ATP-dependent RNA helicase SUPV3L1, mitochondrial; SUV3-like protein 1; suppressor of var1 3-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:338359)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;17961633;19145458;19937380;21750661;22872234;25428506;31219806;34428180;37298184", "class_list": "", "function": "Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (By similarity). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA., [UniProtKB, UniProtKB]; Mice homozygous for Supv3L1 mutation die in utero before midgestation., [RefSeq, PubMed]; SUV3 Helicase and Mitochondrial Homeostasis. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Spatial and temporal aspects of Supv3L1 promoter activity., [RefSeq, PubMed]; Supv3L1 is important for the maintenance of the skin barrier. In addition, loss of Supv3L1 function leads to accelerated aging-like phenotypes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q50HX5", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0045025 mitochondrial degradosome", "go_biological_process": "GO:0006310 DNA recombination;GO:0030307 positive regulation of cell growth;GO:0043066 negative regulation of apoptotic process;GO:0007005 mitochondrion organization;GO:0000957 mitochondrial RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80YD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35403-1", "uniprot_id": "ST3A1_MOUSE", "mass": 35181.0, "length": 293, "protein_name": "Amine sulfotransferase", "gene_name": "Sult3a1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sult3a1; St3a1", "gene_names_refseq": "", "protein_names_uniprotkb": "Amine sulfotransferase; 2.8.2.3; ST3A1; SULT-X2; Sulfotransferase 3A1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "25428506;9647753", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the N-sulfonation of amines., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.3", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0047685 amine sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051923 sulfation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35403-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O89104-1", "uniprot_id": "SYPL2_MOUSE", "mass": 29224.0, "length": 264, "protein_name": "Synaptophysin-like protein 2", "gene_name": "Sypl2", "organism": "Mouse", "refseq_name": "synaptophysin-like protein 2", "refseq_ac": "NP_032622", "gene_names_uniprotkb": "Sypl2; Mg29", "gene_names_refseq": "Mg29; Sypl2", "protein_names_uniprotkb": "Synaptophysin-like protein 2; Mg29; Mitsugumin-29", "protein_names_refseq": "mitsugumin 29; synaptophysin-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:17306)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11988740;14559251;26141232;34203471;39927985;9708916", "class_list": "", "function": "Ca(2+) transients in skeletal muscle are regulated via interaction between Mg29 and TRPC3., [RefSeq, PubMed]; Data show that slow cumulative calcium entry through store-operated calcium channel (SOC) is crucial for long-term calcium homeostasis, such that reduced SOC activity exaggerates muscle fatigue under conditions of intensive exercise., [RefSeq, PubMed]; Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes., [UniProtKB]; MG29 is not involved in the store-operated Ca2+ entry activation at variance with the previous conclusion with immature muscles, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0007507 heart development;GO:0006874 intracellular calcium ion homeostasis;GO:0033292 T-tubule organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O89104-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01852-1", "uniprot_id": "TCB1_MOUSE", "mass": 19346.0, "length": 173, "protein_name": "T-cell receptor beta-1 chain C region", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell receptor beta-1 chain C region", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "6336329;6546606;9881971", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0042105 alpha-beta T cell receptor complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P01852-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09926-1", "uniprot_id": "SURF2_MOUSE", "mass": 30355.0, "length": 257, "protein_name": "Surfeit locus protein 2", "gene_name": "Surf2", "organism": "Mouse", "refseq_name": "surfeit locus protein 2 isoform 1", "refseq_ac": "NP_038706", "gene_names_uniprotkb": "Surf2; Surf-2", "gene_names_refseq": "Surf-2; Surf2", "protein_names_uniprotkb": "Surfeit locus protein 2; Surf-2", "protein_names_refseq": "surfeit locus protein 2 isoform 1; surfeit locus protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20931)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;3025660", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P09926-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56845-1", "uniprot_id": "TCLB5_MOUSE", "mass": 13668.0, "length": 121, "protein_name": "Protein TCL1B5", "gene_name": "Tcl1b5", "organism": "Mouse", "refseq_name": "protein TCL1B5", "refseq_ac": "NP_038804", "gene_names_uniprotkb": "Tcl1b5", "gene_names_refseq": "D12Ertd644e; Tcl1b5", "protein_names_uniprotkb": "Protein TCL1B5", "protein_names_refseq": "protein TCL1B5", "tax_id": 10090, "disease": "", "pathway": " (mmu:27382)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10588720", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P56845-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59529-1", "uniprot_id": "T2R16_MOUSE", "mass": 34761.0, "length": 299, "protein_name": "Taste receptor type 2 member 16", "gene_name": "Tas2r16", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 16", "refseq_ac": "NP_996905", "gene_names_uniprotkb": "Tas2r16; Tas2r118; Tas2r18", "gene_names_refseq": "Gm465; T2R16; T2R18; Tas2r118; Tas2r16; Tas2r18; mGR18; mt2r40", "protein_names_uniprotkb": "Taste receptor type 2 member 16; Candidate taste receptor mt2r40; T2R16; T2R18", "protein_names_refseq": "candidate taste receptor mt2r40; taste receptor type 2 member 16", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (mmu:387347); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11696554;12139982;12581520;12679530", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7M728", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P59529-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59532-1", "uniprot_id": "T2R41_MOUSE", "mass": 36177.0, "length": 308, "protein_name": "Taste receptor type 2 member 41", "gene_name": "Tas2r41", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 41", "refseq_ac": "NP_996911", "gene_names_uniprotkb": "Tas2r41; Tas2r126; Tas2r12; Tas2r26", "gene_names_refseq": "T2R12; T2R26; Tas2r126; Tas2r26; Tas2r41; mGR26; mt2r35", "protein_names_uniprotkb": "Taste receptor type 2 member 41; T2R12; T2R26; T2R41", "protein_names_refseq": "T2R41; taste receptor type 2 member 41", "tax_id": 10090, "disease": "", "pathway": " (mmu:387353); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10761934;11696554;12139982;12581520;12679530;33559206;36059440", "class_list": "", "function": "Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation., [RefSeq, PubMed]; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)., [UniProtKB]; Tas2R signaling enhances mouse neutrophil migration via a ROCK-dependent pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0JNU7;Q7M704", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P59532-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P68372-1", "uniprot_id": "TBB4B_MOUSE", "mass": 49831.0, "length": 445, "protein_name": "Tubulin beta-4B chain", "gene_name": "Tubb4b", "organism": "Mouse", "refseq_name": "tubulin beta-4B chain", "refseq_ac": "NP_666228", "gene_names_uniprotkb": "Tubb4b; Tubb2c", "gene_names_refseq": "4930542G03Rik; Tubb2c1; Tubb2c; Tubb4b", "protein_names_uniprotkb": "Tubulin beta-4B chain; Tubulin beta-2C chain", "protein_names_refseq": "novel tubulin protein; tubulin beta-2C chain; tubulin beta-4B chain; tubulin, beta 2C; tubulin, beta 2c1; tubulin, beta, 2", "tax_id": 10090, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); tubulinopathy (Disease Ontology:DOID:0112227); Leber congenital amaurosis with early-onset deafness (Disease Ontology:DOID:0112240); facial paralysis (Disease Ontology:DOID:13934)", "pathway": " (mmu:227613); (R-MMU-190840); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-2565942); (R-MMU-3371497); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-437239); (R-MMU-5610787); (R-MMU-5620912); (R-MMU-5620920); (R-MMU-5620924); (R-MMU-5626467); (R-MMU-5663220); (R-MMU-6798695); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811436); (R-MMU-68877); (R-MMU-8852276); (R-MMU-8854518); (R-MMU-8955332); (R-MMU-9646399); (R-MMU-9648025); (R-MMU-9668328); (R-MMU-983189); (R-MMU-9833482)", "pathway_count": 31, "publication_count": 24, "publication_id_list": "15890843;19524510;20665223;22645316;23806337;23897886;29187734;29198720;33300544;33414192;34418053;34887587;36288343;37295417;37453647;37507081;3782288;37865089;37989994;38031972;39277687;39627609;39927985;40684658", "class_list": "", "function": "TUBB4B is essential for the cytoskeletal architecture of cochlear supporting cells and motile cilia development. Publication Status: Online-Only, [RefSeq, PubMed]; Tubb4b is required for multi-ciliogenesis in the mouse., [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P05217;Q3TKF0;Q3UJ73;Q99JZ6", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0043209 myelin sheath;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030317 flagellated sperm motility;GO:0000226 microtubule cytoskeleton organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P68372-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U3D7-1", "uniprot_id": "T131L_MOUSE", "mass": 175772.0, "length": 1597, "protein_name": "Transmembrane protein 131-like", "gene_name": "Tmem131l", "organism": "Mouse", "refseq_name": "transmembrane protein 131-like isoform 1 precursor", "refseq_ac": "NP_766269", "gene_names_uniprotkb": "Tmem131l; D930015E06Rik; Kiaa0922", "gene_names_refseq": "D930015E06Rik; Kiaa0922; Tmem131l; mKIAA0922", "protein_names_uniprotkb": "Transmembrane protein 131-like", "protein_names_refseq": "transmembrane protein 131-like isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:229473)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;18299400;21750661;25428506;30084848;30779550;31599954;34203471;34428180;35820727;36210013", "class_list": "", "function": "In its membrane-associated form, antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5E2;Q6PHM5;Q6ZQ24;Q8C2B9;Q8K2U7;Q8R3Y2;Q8R580", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0033088 negative regulation of immature T cell proliferation in thymus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3U3D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UF25-1", "uniprot_id": "STIMA_MOUSE", "mass": 32500.0, "length": 288, "protein_name": "Store-operated calcium entry regulator STIMATE", "gene_name": "Stimate", "organism": "Mouse", "refseq_name": "store-operated calcium entry regulator STIMATE", "refseq_ac": "NP_083115", "gene_names_uniprotkb": "Stimate; Tmem110", "gene_names_refseq": "1810038N08Rik; 2310014H19Rik; Stimate; Tmem110", "protein_names_uniprotkb": "Store-operated calcium entry regulator STIMATE; STIM-activating enhancer encoded by TMEM110; Transmembrane protein 110", "protein_names_refseq": "STIM-activating enhancer encoded by TMEM110; store-operated calcium entry regulator STIMATE; transmembrane protein 110", "tax_id": 10090, "disease": "", "pathway": " (mmu:69179)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26322679", "class_list": "", "function": "Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2J0;Q8C691;Q8R3U0;Q9D7D4;Q9D8S1", "ec_number_list": "", "go_molecular_function": "GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032541 cortical endoplasmic reticulum;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0032237 activation of store-operated calcium channel activity;GO:0002115 store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UF25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499X9-1", "uniprot_id": "SYMM_MOUSE", "mass": 65805.0, "length": 586, "protein_name": "Methionine--tRNA ligase, mitochondrial", "gene_name": "Mars2", "organism": "Mouse", "refseq_name": "methionine--tRNA ligase, mitochondrial precursor", "refseq_ac": "NP_780648", "gene_names_uniprotkb": "Mars2", "gene_names_refseq": "C730026E21Rik; Mars2; MetRS", "protein_names_uniprotkb": "Methionine--tRNA ligase, mitochondrial; 6.1.1.10; Methionyl-tRNA synthetase 2; Mitochondrial methionyl-tRNA synthetase; MtMetRS", "protein_names_refseq": "methionine--tRNA ligase 2; methionine--tRNA ligase, mitochondrial precursor; methionine--tRNA ligase, mitochondrial; methionyl-tRNA synthetase 2; methionyl-tRNA synthetase, mitochondrial; mitochondrial methionine--tRNA ligase; mitochondrial methionyl-tRNA synthetase; mtMetRS", "tax_id": 10090, "disease": "spastic ataxia 3 (Disease Ontology:DOID:0050942); combined oxidative phosphorylation deficiency 25 (Disease Ontology:DOID:0111468); neurodegenerative disease (Disease Ontology:DOID:1289); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:212679)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9W7;Q8BWR9;Q8BXY1", "ec_number_list": "6.1.1.10", "go_molecular_function": "GO:0005524 ATP binding;GO:0004825 methionine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006431 methionyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q499X9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4FZC9-1", "uniprot_id": "SYNE3_MOUSE", "mass": 112035.0, "length": 975, "protein_name": "Nesprin-3", "gene_name": "Syne3", "organism": "Mouse", "refseq_name": "nesprin-3 isoform alpha", "refseq_ac": "NP_001036164", "gene_names_uniprotkb": "Syne3", "gene_names_refseq": "KASH3; Syne3; nesprin-3", "protein_names_uniprotkb": "Nesprin-3; KASH domain-containing protein 3; KASH3; Nuclear envelope spectrin repeat protein 3", "protein_names_refseq": "KASH domain-containing protein 3; nesprin-3 isoform alpha; nuclear envelope spectrin repeat protein 3", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:212073)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16330710;17881500;18396275;18638474;18827015;22518138;25428506;30084848;31219806;32948197", "class_list": "", "function": "As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells (By similarity)., [UniProtKB, PubMed]; Data support a model in which the actin cytoskeleton influences the binding of plectin dimers to dimers of nesprin-3alpha, which in turn are retained at the nuclear envelope through an interaction with Sun proteins., [RefSeq, PubMed]; Expression profile of SYNE3 and bioinformatic analysis of its prognostic value and functions in tumors. Publication Status: Online-Only, [RefSeq, PubMed]; Plectin binds to the integrin alpha6beta4 at the cell surface and to nesprin-3 at the ONM in keratinocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMM1;Q8C117", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0140444 cytoskeleton-nuclear membrane anchor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0008360 regulation of cell shape;GO:0090150 establishment of protein localization to membrane;GO:0007097 nuclear migration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q4FZC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5D525-1", "uniprot_id": "SYC1L_MOUSE", "mass": 28461.0, "length": 247, "protein_name": "Synaptonemal complex central element protein 1-like", "gene_name": "Syce1l", "organism": "Mouse", "refseq_name": "synaptonemal complex central element protein 1-like isoform 1", "refseq_ac": "NP_001041610", "gene_names_uniprotkb": "Syce1l; Mmrp2", "gene_names_refseq": "4930481F22Rik; MMRP; PSESS; Syce1l; mmrp2", "protein_names_uniprotkb": "Synaptonemal complex central element protein 1-like; Meiosis-related protein", "protein_names_refseq": "meiosis-related protein; predicted second spermatocyte specific protein; synaptonemal complex central element protein 1-like isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:668110)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16328886", "class_list": "", "function": "An isoform of 4930481F22, lacking the 7th exon, encodes a putative 28.4 kDa protein expressed in spermatocytes, and may have an important role in meiosis., [RefSeq, PubMed]; May be involved in meiosis. Isoform 1 may be involved in meiosis during spermatogenesis while isoform 2 is probably related to a later stage of meiosis, in the development stage of secondary spermatocytes and spermatids., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RUQ1;Q497L4;Q5D524;Q9D5A5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0045111 intermediate filament cytoskeleton;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007130 synaptonemal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5D525-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F2E8-1", "uniprot_id": "TAOK1_MOUSE", "mass": 116050.0, "length": 1001, "protein_name": "Serine/threonine-protein kinase TAO1", "gene_name": "Taok1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase TAO1", "refseq_ac": "NP_659074", "gene_names_uniprotkb": "Taok1; Kiaa1361", "gene_names_refseq": "2810468K05Rik; D130018F14Rik; Map3k16; Markk; Psk2; Taok1", "protein_names_uniprotkb": "Serine/threonine-protein kinase TAO1; 2.7.11.1; Thousand and one amino acid protein 1", "protein_names_refseq": "serine/threonine protein kinase TAO1 homolog; serine/threonine-protein kinase TAO1; thousand and one amino acid protein 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); cancer (Disease Ontology:DOID:162); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (mmu:216965); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 13, "publication_id_list": "16452087;17114649;17417629;19144319;21183079;30084848;31219806;33565190;34428180;36210013;36595571;37656623;9786855", "class_list": "", "function": "Functional analysis of the human Tao1 ortholog., [RefSeq, PubMed]; Isolation and functional characterization of the rat Taok1 ortholog, and comparison to human TAOK1., [RefSeq, PubMed]; Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase., [RefSeq, PubMed]; Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G protein-coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade (By similarity). During fetal development, it plays an essential role in the regulation of neuronal differentiation and migration to the cortical plate (PubMed:33565190)., [UniProtKB, PubMed]; Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZL2;Q8JZX2;Q91VG7", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;3.6.5.-;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;3.4.22.49;3.6.5.2;3.1.3.16;2.7.11.39;2.3.1.-;2.7.11.31;3.4.21.-;2.3.1.48;4.1.1.32;3.6.4.12;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.3.2.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006281 DNA repair;GO:0006468 protein phosphorylation;GO:0032956 regulation of actin cytoskeleton organization;GO:0046330 positive regulation of JNK cascade;GO:0070050 neuron cellular homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5F2E8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5G5D5-1", "uniprot_id": "SYNA_MOUSE", "mass": 68657.0, "length": 617, "protein_name": "Syncytin-A", "gene_name": "Syna", "organism": "Mouse", "refseq_name": "syncytin-A precursor", "refseq_ac": "NP_001013773", "gene_names_uniprotkb": "Syna", "gene_names_refseq": "Gm453; Gm52; Syna; syncytin-A", "protein_names_uniprotkb": "Syncytin-A", "protein_names_refseq": "envelope glycoprotein syncytin-A; syncytin-A precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:214292)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15644441;17105734;17762178;18077339;18448564;19564597;22032925;27589388;39121585", "class_list": "", "function": "Critical role of syncytin-A and -B in syncytiotrophoblast formation, a situation where two pairs of endogenous retroviruses, independently acquired by primate and rodent lineages, were selected for a convergent physiological role. (syncytin-A, syncytin-B), [RefSeq, PubMed]; Findings show that in both humans and mice, one of the two syncytins (human syncytin-2 and mouse syncytin-B) is immunosuppressive and, rather unexpectedly, the other (human syncytin-1 and mouse syncytin-A) is not, [RefSeq, PubMed]; Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of a mouse endogenous retrovirus provirus on chromosome 5 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015]., [RefSeq]; Present evidence in support of the direct role for syncytin-A in mouse trophoblast stem cell fusion and differentiation involved in placental dev, [RefSeq, PubMed]; Reduced syncytin-1 regulates trophoblast invasion and apoptosis in preeclampsia., [RefSeq, PubMed]; Syncytin-A is a candidate regulator of fusion from retroviral origin, [RefSeq, PubMed]; This endogenous retroviral envelope protein has retained its original fusogenic properties (PubMed:15644441, PubMed:17762178, PubMed:18077339, PubMed:19564597, PubMed:27589388). Together with Synb, participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis (PubMed:19564597). Syna is essential for placental development and is specifically required for formation of syncytiotrophoblast layer I (SynT-I) (PubMed:19564597). Promotes muscle myoblast fusion (PubMed:27589388). Does not have immunosuppressive activity (PubMed:18077339)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006949 syncytium formation;GO:0000768 syncytium formation by plasma membrane fusion;GO:0007520 myoblast fusion;GO:0060711 labyrinthine layer development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5G5D5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QD04-1", "uniprot_id": "TAAR9_MOUSE", "mass": 38901.0, "length": 348, "protein_name": "Trace amine-associated receptor 9", "gene_name": "Taar9", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 9", "refseq_ac": "NP_001010831", "gene_names_uniprotkb": "Taar9", "gene_names_refseq": "Gm231; Taar9; taR-9", "protein_names_uniprotkb": "Trace amine-associated receptor 9; TaR-9; Trace amine receptor 9; mTaar9", "protein_names_refseq": "mTaar9; trace amine-associated receptor 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:503558); (R-MMU-375280); (R-MMU-418555)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15718104;16878137;23624375;34428180;34600890;35177711;37225986", "class_list": "", "function": "Convergent olfactory trace amine-associated receptors detect biogenic polyamines with distinct motifs via a conserved binding site., [RefSeq, PubMed]; Olfactory receptor specific for trace amines, such as triethylamine, N,N-dimethylcyclohexylamine (DMCHA), beta-phenylethylamine (beta-PEA), cadaverine (CAD) and polyamines such as spermine and spermidine (PubMed:34600890, PubMed:35177711, PubMed:37225986). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (PubMed:37225986). Trace amine-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (PubMed:37225986). In mature olfactory sensory neurons, Taar9 is coupled with GNAL/G(olf)G alpha protein and mediates activation of adenylate cyclase activity to activate cAMP signaling and eventually transmit odorant signals to achieve membrane depolarization (PubMed:37225986). In immature olfactory sensory neurons, Taar9 is coupled with GNAS/G(s) G alpha proteins (PubMed:37225986)., [UniProtKB, PubMed, PubMed, PubMed]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]; Structural basis of amine odorant perception by a mammal olfactory receptor., [RefSeq, PubMed]; Two entry tunnels in mouse TAAR9 suggest the possibility of multi-entry tunnels in olfactory receptors. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 38, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RT07", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5QD04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QD13-1", "uniprot_id": "TAAR6_MOUSE", "mass": 38279.0, "length": 345, "protein_name": "Trace amine-associated receptor 6", "gene_name": "Taar6", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 6", "refseq_ac": "NP_001010828", "gene_names_uniprotkb": "Taar6; Gm228", "gene_names_refseq": "Gm228; Taar6; taR-6", "protein_names_uniprotkb": "Trace amine-associated receptor 6; TaR-6; Trace amine receptor 6; mTaar6", "protein_names_refseq": "trace amine-associated receptor 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:215855); (R-MMU-375280); (R-MMU-418555)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15718104;16878137;22837392;23624375;34428180;36139098;37225986", "class_list": "", "function": "Olfactory receptor specific for trace amines, such as beta-phenylethylamine (beta-PEA) (PubMed:37225986). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (PubMed:37225986). Beta-PEA-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (PubMed:37225986)., [UniProtKB, PubMed]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]; Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5QD13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QD15-1", "uniprot_id": "TAAR4_MOUSE", "mass": 38904.0, "length": 347, "protein_name": "Trace amine-associated receptor 4", "gene_name": "Taar4", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 4", "refseq_ac": "NP_001008499", "gene_names_uniprotkb": "Taar4; Gm226", "gene_names_refseq": "Gm226; Ta2; Taar4; taR-4", "protein_names_uniprotkb": "Trace amine-associated receptor 4; 2-phenylethylamine receptor; TaR-4; Trace amine receptor 4; mTaar4", "protein_names_refseq": "2-phenylethylamine receptor; mTaar4; trace amine receptor 2; trace amine receptor 4; trace amine-associated receptor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:209513)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15718104;16878137;21690383;22545963;22837392;23624375;25616211;30038239;37225986", "class_list": "", "function": "In mouse, TAAR4 is encoded by adjacent genes and localize to adjacent glomeruli, yet mediate opposing behaviors. Review article, [RefSeq, PubMed]; Olfactory receptor specific for 2-phenylethylamine, a trace amine present at high concentration in the urine of carnivore species, playing a key role in fear and avoidance responses (PubMed:16878137, PubMed:21690383, PubMed:22545963, PubMed:23624375, PubMed:30038239, PubMed:37225986). 2-phenylethylamine acts as a kairomone in the chemical detection of carnivore odor and triggers fear in mice (PubMed:16878137, PubMed:21690383, PubMed:23624375). This receptor is probably mediated by the G(s)-class of G proteins which activate adenylate cyclase (PubMed:16878137, PubMed:21690383, PubMed:23624375)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]; TAAR3, TAAR4 and TAAR5 are evolutionarily conserved and determine the sensitivity to a class of biologically relevant chemicals Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity;GO:0008227 G protein-coupled amine receptor activity;GO:1990080 2-phenylethylamine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0001662 behavioral fear response;GO:0007635 chemosensory behavior;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5QD15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QD16-1", "uniprot_id": "TAAR3_MOUSE", "mass": 38745.0, "length": 343, "protein_name": "Trace amine-associated receptor 3", "gene_name": "Taar3", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 3", "refseq_ac": "NP_001008429", "gene_names_uniprotkb": "Taar3", "gene_names_refseq": "Taar3", "protein_names_uniprotkb": "Trace amine-associated receptor 3; TaR-3; Trace amine receptor 3; mTaar3", "protein_names_refseq": "mTaar3; taR-3; trace amine receptor 3; trace amine-associated receptor 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:493809); (R-MMU-375280); (R-MMU-418555)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "15718104;16878137;22545963;23624375;30038239", "class_list": "", "function": "Olfactory receptor activated by several primary trace amines, including isoamylamine (PubMed:16878137, PubMed:22545963, PubMed:30038239). Activated by isoamylamine and cyclohexylamine, but not to the corresponding alcohols, isoamylalcohol and cyclohexanol (PubMed:16878137). This receptor is probably mediated by the G(s)-class of G proteins which activate adenylate cyclase (PubMed:16878137)., [UniProtKB, PubMed, PubMed, PubMed]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]; TAAR3, TAAR4 and TAAR5 are evolutionarily conserved and determine the sensitivity to a class of biologically relevant chemicals Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RT86", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5QD16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QD17-1", "uniprot_id": "TAAR2_MOUSE", "mass": 38517.0, "length": 339, "protein_name": "Trace amine-associated receptor 2", "gene_name": "Taar2", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 2", "refseq_ac": "NP_001007267", "gene_names_uniprotkb": "Taar2; Gm225; Gpr58", "gene_names_refseq": "Gm224; Gm225; Gpr58; Taar2; Tarr2", "protein_names_uniprotkb": "Trace amine-associated receptor 2; G protein-coupled receptor 58; TaR-2; Trace amine receptor 2; mTaar2", "protein_names_refseq": "G protein-coupled receptor 58; mTaar2; taR-2; trace amine receptor 2; trace amine-associated receptor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:209512); (R-MMU-375280); (R-MMU-418555)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12679517;15718104;16878137;23624375;35431833", "class_list": "", "function": "Orphan olfactory receptor specific for trace amines (By similarity). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (By similarity). Ligand-binding causes a conformation change that triggers signaling via the G(s)-class of G proteins which activate adenylate cyclase (By similarity). May also be required to provide olfactory input into limbic brain areas to regulate emotional behaviors likely via modulation of the dopamine system (PubMed:35431833)., [UniProtKB, UniProtKB, PubMed]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6H6B2;Q80T53", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5QD17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62282-1", "uniprot_id": "TAL2_MOUSE", "mass": 12315.0, "length": 108, "protein_name": "T-cell acute lymphocytic leukemia protein 2 homolog", "gene_name": "Tal2", "organism": "Mouse", "refseq_name": "T-cell acute lymphocytic leukemia protein 2 homolog", "refseq_ac": "NP_033343", "gene_names_uniprotkb": "Tal2", "gene_names_refseq": "Tal2; bHLHa19", "protein_names_uniprotkb": "T-cell acute lymphocytic leukemia protein 2 homolog; TAL-2", "protein_names_refseq": "T-cell acute lymphocytic leukemia protein 2 homolog; TAL-2", "tax_id": 10090, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:21350)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1763056", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0035264 multicellular organism growth;GO:0009791 post-embryonic development;GO:0030901 midbrain development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62282-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64356-1", "uniprot_id": "SVS6_MOUSE", "mass": 11482.0, "length": 99, "protein_name": "Seminal vesicle secretory protein 6", "gene_name": "Svs6", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Svs6; Svp6", "gene_names_refseq": "", "protein_names_uniprotkb": "Seminal vesicle secretory protein 6; SVS VI; SVSP99; Seminal vesicle protein 6; Seminal vesicle secretory protein VI", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "8373512;8748137", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VEF9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64356-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FE7-1", "uniprot_id": "T151B_MOUSE", "mass": 61706.0, "length": 561, "protein_name": "Transmembrane protein 151B", "gene_name": "Tmem151b", "organism": "Mouse", "refseq_name": "transmembrane protein 151B", "refseq_ac": "NP_001013771", "gene_names_uniprotkb": "Tmem151b; Gm323", "gene_names_refseq": "Gm323; Nmf389; Tmem151b", "protein_names_uniprotkb": "Transmembrane protein 151B", "protein_names_refseq": "transmembrane protein 151B", "tax_id": 10090, "disease": "", "pathway": " (mmu:210573)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XJV8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76HP3-1", "uniprot_id": "T132D_MOUSE", "mass": 121488.0, "length": 1097, "protein_name": "Transmembrane protein 132D", "gene_name": "Tmem132d", "organism": "Mouse", "refseq_name": "transmembrane protein 132D precursor", "refseq_ac": "NP_766473", "gene_names_uniprotkb": "Tmem132d; Molt", "gene_names_refseq": "C630028F04Rik; Tmem132d", "protein_names_uniprotkb": "Transmembrane protein 132D; Mature OL transmembrane protein; Mature oligodendrocytes transmembrane protein", "protein_names_refseq": "mature OL transmembrane protein; mature oligodendrocytes transmembrane protein; transmembrane protein 132D precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:243274)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12966072;29317594;35690356", "class_list": "", "function": "Higher expression of Tmem132d in the anterior cingulate cortex causes increased anxiety-related behavior Publication Status: Online-Only, [RefSeq, PubMed]; Regulates neuronal morphology via inhibition of the WAVE regulatory complex (WCR), a complex that controls F-actin cytoskeletal dynamics., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J0I2;B2RU39;Q8C422", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q76HP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M720-1", "uniprot_id": "T2R13_MOUSE", "mass": 35521.0, "length": 305, "protein_name": "Taste receptor type 2 member 13", "gene_name": "Tas2r13", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 13", "refseq_ac": "NP_996907", "gene_names_uniprotkb": "Tas2r13; Tas2r121", "gene_names_refseq": "T2R21; Tas2r121; Tas2r13; Tas2r21; mGR21; mT2r48", "protein_names_uniprotkb": "Taste receptor type 2 member 13; T2R121; T2R13; Taste receptor type 2 member 121; mT2R48", "protein_names_refseq": "T2R121; T2R13; taste receptor type 2 member 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:387349); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "12679530;30779550", "class_list": "", "function": "Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7M720-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQA5-1", "uniprot_id": "T2R39_MOUSE", "mass": 36308.0, "length": 319, "protein_name": "Taste receptor type 2 member 39", "gene_name": "Tas2r39", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 39", "refseq_ac": "NP_851792", "gene_names_uniprotkb": "Tas2r39; T2r34; Tas2r139", "gene_names_refseq": "Tas2r139; Tas2r39; mt2r34", "protein_names_uniprotkb": "Taste receptor type 2 member 39; T2R39; mT2R34", "protein_names_refseq": "T2R39; candidate taste receptor mt2r34; taste receptor type 2 member 39", "tax_id": 10090, "disease": "", "pathway": " (mmu:353148); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "12679530;12734386", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TQA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQB8-1", "uniprot_id": "T2R40_MOUSE", "mass": 36559.0, "length": 319, "protein_name": "Taste receptor type 2 member 40", "gene_name": "Tas2r40", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 40", "refseq_ac": "NP_001001453", "gene_names_uniprotkb": "Tas2r40; T2r33; Tas2r144; Tas2r44", "gene_names_refseq": "Tas2r144; Tas2r40; Tas2r44; mt2r33", "protein_names_uniprotkb": "Taste receptor type 2 member 40; T2R40; mT2R33", "protein_names_refseq": "T2R40; taste receptor type 2 member 40", "tax_id": 10090, "disease": "", "pathway": " (mmu:387515); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "12679530;12734386;25428506;31219806", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TQB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BI41-1", "uniprot_id": "SYNB_MOUSE", "mass": 69514.0, "length": 618, "protein_name": "Syncytin-B", "gene_name": "Synb", "organism": "Mouse", "refseq_name": "syncytin-B precursor", "refseq_ac": "NP_775596", "gene_names_uniprotkb": "Synb", "gene_names_refseq": "D930020E02Rik; Synb; syncytin-B", "protein_names_uniprotkb": "Syncytin-B", "protein_names_refseq": "envelope glycoprotein syncytin-B; placenta-specific/fusogenic; syncytin-B precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:239167)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15644441;18077339;18448564;22032925;27589388;39287391", "class_list": "", "function": "Critical role of syncytin-A and -B in syncytiotrophoblast formation, a situation where two pairs of endogenous retroviruses, independently acquired by primate and rodent lineages, were selected for a convergent physiological role. (syncytin-A, syncytin-B), [RefSeq, PubMed]; Findings show that in both humans and mice, one of the two syncytins (human syncytin-2 and mouse syncytin-B) is immunosuppressive and, rather unexpectedly, the other (human syncytin-1 and mouse syncytin-A) is not, [RefSeq, PubMed]; Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015]., [RefSeq]; Sodium-dependent phosphate transporter PiT1/SLC20A1 as the receptor for the endogenous retroviral envelope syncytin-B involved in mouse placenta formation., [RefSeq, PubMed]; Synb is co-expressed with Cebpa and Gcm1 in basal cells in contact with the allantois., [RefSeq, PubMed]; This endogenous retroviral envelope protein has retained its original fusogenic properties (PubMed:15644441, PubMed:18077339, PubMed:22032925, PubMed:27589388). Together with Syna, participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis (PubMed:22032925). Synb is specifically involved in formation of syncytiotrophoblast layer II (SynT-II) (PubMed:22032925). Promotes myoblast fusion, and may play a role in regeneration of damaged muscle tissue in males (PubMed:27589388). May have immunosuppressive activity (PubMed:18077339)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "V9GXQ5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006949 syncytium formation;GO:0000768 syncytium formation by plasma membrane fusion;GO:0007520 myoblast fusion;GO:0060716 labyrinthine layer blood vessel development;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BI41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIP0-1", "uniprot_id": "SYDM_MOUSE", "mass": 74102.0, "length": 653, "protein_name": "Aspartate--tRNA ligase, mitochondrial", "gene_name": "Dars2", "organism": "Mouse", "refseq_name": "aspartate--tRNA ligase, mitochondrial precursor", "refseq_ac": "NP_766232", "gene_names_uniprotkb": "Dars2", "gene_names_refseq": "5830468K18Rik; Dars2; aspRS", "protein_names_uniprotkb": "Aspartate--tRNA ligase, mitochondrial; 6.1.1.12; AspRS; Aspartyl-tRNA synthetase", "protein_names_refseq": "aspartate--tRNA ligase, mitochondrial precursor; aspartate--tRNA ligase, mitochondrial", "tax_id": 10090, "disease": "leukodystrophy (Disease Ontology:DOID:10579)", "pathway": " (mmu:226539)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;24606902", "class_list": "", "function": "Catalyzes the attachment of aspartate to tRNA(Asp) in a two-step reaction: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)., [UniProtKB, UniProtKB]; DARS2 depletion in heart and skeletal muscle leads to the severe deregulation of mitochondrial protein synthesis followed by a strong respiratory chain deficit in both tissues., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWV4", "ec_number_list": "6.1.1.12", "go_molecular_function": "GO:0004815 aspartate-tRNA ligase activity;GO:0050560 aspartate-tRNA(Asn) ligase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0070145 mitochondrial asparaginyl-tRNA aminoacylation;GO:0006422 aspartyl-tRNA aminoacylation;GO:0043039 tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BIP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJQ4-1", "uniprot_id": "TCAM2_MOUSE", "mass": 26362.0, "length": 232, "protein_name": "TIR domain-containing adapter molecule 2", "gene_name": "Ticam2", "organism": "Mouse", "refseq_name": "TIR domain-containing adapter molecule 2", "refseq_ac": "NP_775570", "gene_names_uniprotkb": "Ticam2; Tirp; Tram", "gene_names_refseq": "B430113A10; TICAM-2; TRAM; Ticam2; Tirp; Trif", "protein_names_uniprotkb": "TIR domain-containing adapter molecule 2; TICAM-2; TRIF-related adapter molecule; Toll/interleukin-1 receptor domain-containing protein", "protein_names_refseq": "TIR domain-containing adapter molecule 2; TIR domain-containing adapter protein; TRIF-related adapter molecule TRAM; TRIF-related adaptor molecule; Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2; toll-like receptor adaptor molecule 2; toll/interleukin-1 receptor domain-containing protein", "tax_id": 10090, "disease": "Coronavirus infectious disease (Disease Ontology:DOID:0080599)", "pathway": " (mmu:225471); (R-MMU-140534); (R-MMU-166016); (R-MMU-166166); (R-MMU-2562578); (R-MMU-6798695); (R-MMU-936964); (R-MMU-937041); (R-MMU-937072); (R-MMU-975163); (R-MMU-9824878)", "pathway_count": 11, "publication_count": 9, "publication_id_list": "12721283;14517278;14519765;14556004;18297073;22685567;38188180;38548850;39158930", "class_list": "", "function": "Functions as a sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. Erratum:[J Exp Med. 2003 Nov 3;198(9):following 1450], [RefSeq, PubMed]; MYELOID-DERIVED TLR4-TRIF SIGNALING PATHWAY MEDIATES OXIDATIVE STRESS IN LPS/D-GALN-INDUCED ACUTE LIVER FAILURE., [RefSeq, PubMed]; The role of TRIF protein in regulating the proliferation and antigen presentation ability of myeloid dendritic cells through the ERK1/2 signaling pathway in chronic low-grade inflammation of intestinal mucosa mediated by flagellin-TLR5 complex signal. Publication Status: Online-Only, [RefSeq, PubMed]; ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U996", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005543 phospholipid binding;GO:0046982 protein heterodimerization activity;GO:0035591 signaling adaptor activity;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BJQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTG3-1", "uniprot_id": "T11L1_MOUSE", "mass": 56332.0, "length": 509, "protein_name": "T-complex protein 11-like protein 1", "gene_name": "Tcp11l1", "organism": "Mouse", "refseq_name": "T-complex protein 11-like protein 1", "refseq_ac": "NP_796164", "gene_names_uniprotkb": "Tcp11l1", "gene_names_refseq": "C130096D04Rik; Tcp11l1", "protein_names_uniprotkb": "T-complex protein 11-like protein 1", "protein_names_refseq": "T-complex protein 11-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:320554)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "27802388;30084848;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BTG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C6N3-1", "uniprot_id": "SYT15_MOUSE", "mass": 47270.0, "length": 418, "protein_name": "Synaptotagmin-15", "gene_name": "Syt15", "organism": "Mouse", "refseq_name": "synaptotagmin-15 isoform b", "refseq_ac": "NP_795905", "gene_names_uniprotkb": "Syt15", "gene_names_refseq": "CHR10SYT; E230025K04Rik; Syt15; sytXV", "protein_names_uniprotkb": "Synaptotagmin-15; Synaptotagmin XV; SytXV", "protein_names_refseq": "synaptotagmin-15 isoform b; synaptotagmin-15", "tax_id": 10090, "disease": "", "pathway": " (mmu:319508)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12788067;34428180;35820727", "class_list": "", "function": "May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues., [UniProtKB]; Molecular cloning and structure, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RTF1;Q7TN81;Q7TN82;Q8C999", "ec_number_list": "", "go_molecular_function": "GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070382 exocytic vesicle", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C6N3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R086-1", "uniprot_id": "SUOX_MOUSE", "mass": 60756.0, "length": 546, "protein_name": "Sulfite oxidase, mitochondrial", "gene_name": "Suox", "organism": "Mouse", "refseq_name": "sulfite oxidase, mitochondrial precursor", "refseq_ac": "NP_776094", "gene_names_uniprotkb": "Suox", "gene_names_refseq": "SO; Suox", "protein_names_uniprotkb": "Sulfite oxidase, mitochondrial; 1.7.-.-; 1.8.3.1; Nitrite reductase, mitochondrial", "protein_names_refseq": "sulfite oxidase, mitochondrial precursor; sulfite oxidase, mitochondrial", "tax_id": 10090, "disease": "isolated sulfite oxidase deficiency (Disease Ontology:DOID:0111270); inherited metabolic disorder (Disease Ontology:DOID:655); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:211389); (R-MMU-1614517)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "22854042;26171830;26740625;30084848;31167903;31219806;34001919;34428180;35820727;37507081", "class_list": "", "function": "Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids (By similarity). Can run in reverse direction and reduce nitrite to nitric oxide under physiologically relevant conditions, such as hypoxia (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Increased hippocampal excitability in miR-324-null mice. Publication Status: Online-Only, [RefSeq, PubMed]; Mechanism of nitrite-dependent NO synthesis by human sulfite oxidase. Publication Status: Online-Only, [RefSeq, PubMed]; The identified molecular hierarchy of SO maturation represents a novel link between the canonical presequence pathway and folding-trap mechanisms of mitochondrial import, [RefSeq, PubMed]; This finding suggests the possibility to use oxygen-reactive SO variants in sulfite detoxification, as the loss of SO activity is causing severe neurodegeneration, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3S5;Q3UEP6", "ec_number_list": "1.8.3.1;1.7.-.-", "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0020037 heme binding;GO:0043546 molybdopterin cofactor binding;GO:0008482 sulfite oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0007584 response to nutrient;GO:0006790 sulfur compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8R086-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R218-1", "uniprot_id": "T150B_MOUSE", "mass": 26578.0, "length": 238, "protein_name": "Modulator of macroautophagy TMEM150B", "gene_name": "Tmem150b", "organism": "Mouse", "refseq_name": "modulator of macroautophagy TMEM150B isoform 1", "refseq_ac": "NP_001136264", "gene_names_uniprotkb": "Tmem150b", "gene_names_refseq": "A630041N19; Tmem150b; Tmem224", "protein_names_uniprotkb": "Modulator of macroautophagy TMEM150B; Transmembrane protein 150B", "protein_names_refseq": "modulator of macroautophagy TMEM150B isoform 1; modulator of macroautophagy TMEM150B; transmembrane protein 224", "tax_id": 10090, "disease": "", "pathway": " (mmu:330460)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "33288838", "class_list": "", "function": "Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (By similarity). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (By similarity). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (By similarity)., [UniProtKB, UniProtKB]; TMEM150B is dispensable for oocyte maturation and female fertility in mouse. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C9L9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R218-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2N0-1", "uniprot_id": "TAP26_MOUSE", "mass": 28034.0, "length": 240, "protein_name": "Thyroid transcription factor 1-associated protein 26", "gene_name": "Ccdc59", "organism": "Mouse", "refseq_name": "thyroid transcription factor 1-associated protein 26", "refseq_ac": "NP_079878", "gene_names_uniprotkb": "Ccdc59; D10Ertd718e; Tap26", "gene_names_refseq": "2300004H16Rik; Ccdc59; D10Ertd718e", "protein_names_uniprotkb": "Thyroid transcription factor 1-associated protein 26; Coiled-coil domain-containing protein 59; TTF-1-associated protein 26", "protein_names_refseq": "TTF-1-associated protein 26; coiled-coil domain-containing protein 59; thyroid transcription factor 1-associated protein 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:52713); (R-MMU-5683826)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ86;Q9CR69;Q9CV91", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2N0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3F9-1", "uniprot_id": "STPAP_MOUSE", "mass": 94603.0, "length": 869, "protein_name": "Speckle targeted PIP5K1A-regulated poly(A) polymerase", "gene_name": "Tut1", "organism": "Mouse", "refseq_name": "speckle targeted PIP5K1A-regulated poly(A) polymerase", "refseq_ac": "NP_932110", "gene_names_uniprotkb": "Tut1; Rbm21", "gene_names_refseq": "2700038E08Rik; PAPD2; Rbm21; TUTase6; Tent1; Tut1; U6-TUTase; star-PAP", "protein_names_uniprotkb": "Speckle targeted PIP5K1A-regulated poly(A) polymerase; 2.7.7.19; 2.7.7.52; RNA-binding motif protein 21; RNA-binding protein 21; Star-PAP; U6 snRNA-specific terminal uridylyltransferase 1; U6-TUTase", "protein_names_refseq": "RNA binding motif protein 21; speckle targeted PIP5K1A-regulated poly(A) polymerase", "tax_id": 10090, "disease": "", "pathway": " (mmu:70044); (R-MMU-9770562)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17525332;21183079;24768001;25428506;27802388;32839293;39627609", "class_list": "", "function": "Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation., [UniProtKB, UniProtKB]; TUT1 nucleotidyl transferase interacts with LARP7 protein to regulate Lin28 expression., [RefSeq, PubMed]; USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUH3", "ec_number_list": "2.7.7.19;2.7.7.52;3.6.4.13;3.1.13.-;2.7.7.48;2.7.7.6;3.1.3.16;3.1.3.53;2.3.2.27;2.7.7.-;2.7.1.78;3.1.27.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0051252 regulation of RNA metabolic process;GO:0034477 U6 snRNA 3'-end processing;GO:0016180 snRNA processing;GO:0031124 mRNA 3'-end processing;GO:0031123 RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R3F9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3R5-1", "uniprot_id": "T185B_MOUSE", "mass": 40701.0, "length": 350, "protein_name": "Transmembrane protein 185B", "gene_name": "Tmem185b", "organism": "Mouse", "refseq_name": "transmembrane protein 185B", "refseq_ac": "NP_666215", "gene_names_uniprotkb": "Tmem185b; Ee3-2; Fam11b", "gene_names_refseq": "2500001K11Rik; Tmem185b", "protein_names_uniprotkb": "Transmembrane protein 185B; Erythropoietin-induced EST 3-2; Protein FAM11B", "protein_names_refseq": "ee3_2; erythropoietin-induced EST 3-2; transmembrane protein 185B", "tax_id": 10090, "disease": "", "pathway": " (mmu:226351)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15525354", "class_list": "", "function": "The mouse ee3 is an orphan G-protein-coupled receptor with potential connections to erythropoietin and 5HT2a receptor signalling. ee3_2, a similar gene, is also described, along with human orthologs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSP3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R3R5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCK7-1", "uniprot_id": "SYCN_MOUSE", "mass": 14595.0, "length": 134, "protein_name": "Syncollin", "gene_name": "Sycn", "organism": "Mouse", "refseq_name": "syncollin precursor", "refseq_ac": "NP_080992", "gene_names_uniprotkb": "Sycn", "gene_names_refseq": "0910001K16Rik; 1810038B08Rik; SYL; Sycn", "protein_names_uniprotkb": "Syncollin", "protein_names_refseq": "syncollin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:68416)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11839820;15040787;15462671;30084848", "class_list": "", "function": "Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues., [UniProtKB, PubMed, PubMed, PubMed]; Syncollin is required for efficient exocytosis in the pancreatic acinar cell, and it plays a particularly important role in compound exocytosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0042589 zymogen granule membrane", "go_biological_process": "GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VCK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XD3-1", "uniprot_id": "T4S4_MOUSE", "mass": 21296.0, "length": 202, "protein_name": "Transmembrane 4 L6 family member 4", "gene_name": "Tm4sf4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tm4sf4", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane 4 L6 family member 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91XD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MT6-1", "uniprot_id": "SUCR1_MOUSE", "mass": 36765.0, "length": 317, "protein_name": "Succinate receptor 1", "gene_name": "Sucnr1", "organism": "Mouse", "refseq_name": "succinate receptor 1", "refseq_ac": "NP_115776", "gene_names_uniprotkb": "Sucnr1; Gpr91", "gene_names_refseq": "Gpr91; Sucnr1", "protein_names_uniprotkb": "Succinate receptor 1; G protein-coupled receptor 91", "protein_names_refseq": "G protein-coupled receptor 91; succinate receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:84112); (R-MMU-373076); (R-MMU-418594)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "11273702;15141213;18535668;18820681;19389848;27481132;29735652;30084848;30779550;30962591;32946811;34428180;36977414;37947659", "class_list": "", "function": "G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (PubMed:15141213). Succinate-SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasis (PubMed:18820681, PubMed:27481132, PubMed:29735652, PubMed:30962591). In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells (PubMed:27481132, PubMed:30962591). Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involved in immune function (By similarity). In activated M1 macrophages, plays a pro-inflammatory role in response to LPS (PubMed:27481132). Expressed in dendritic cells, where it is involved in the sensing of immunological danger and enhances immunity. Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well as an enhancement of antigen-specific activation of helper T cells (PubMed:18820681). In the small intestine, mediates the activation of tuft cells by dietary succinate and triggers type 2 immunity (PubMed:29735652). In adipocytes, plays an important role in the control of energy metabolism. In response to succinate, controls leptin expression in an AMPK-JNK-CEBPA-dependent as well as circadian clock-regulated manner (PubMed:36977414). In muscle tissue, is expressed in non-muscle cells and coordinates muscle remodeling in response to the succinate produced during exercise training in a paracrine manner (PubMed:32946811). In retina, acts as a mediator of vessel growth during retinal development. In response to succinate, regulates the production of angiogenic factors, including VEGF, by retinal ganglion neurons (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; G-Protein-Coupled Receptor 91-Dependent Signalling Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidaemic Mice. Publication Status: Online-Only, [RefSeq, PubMed]; GPR91, a previously orphan G-protein-coupled receptor, functions as a receptor for the citric acid cycle intermediate succinate, [RefSeq, PubMed]; Macul densa cells can sense alterations in local tissue metabolism via accumulation of tubular succinate and GPR91 signaling., [RefSeq, PubMed]; Release of the prohypertensive hormone renin by the kidney, triggered by high levels of glucose, is mediated by a succinate / GPR91 paracrine signaling cascade in the glomerular endothelium., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V9V9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0051592 response to calcium ion;GO:0060177 regulation of angiotensin metabolic process;GO:0097009 energy homeostasis;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99MT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ66-1", "uniprot_id": "DYT2B_MOUSE", "mass": 16499.0, "length": 144, "protein_name": "Dynein light chain Tctex-type protein 2B", "gene_name": "Dynlt2b", "organism": "Mouse", "refseq_name": "dynein light chain Tctex-type protein 2B isoform 1", "refseq_ac": "NP_079605", "gene_names_uniprotkb": "Dynlt2b; Tctex1d2", "gene_names_refseq": "0610012D17Rik; 2410011K15Rik; Dynlt2b; Tctex1d2", "protein_names_uniprotkb": "Dynein light chain Tctex-type protein 2B; Tctex1 domain-containing protein 2", "protein_names_refseq": "Tctex1 domain containing 2; dynein light chain Tctex-type protein 2B isoform 1; dynein light chain Tctex-type protein 2B; tctex1 domain-containing protein 2", "tax_id": 10090, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); ciliopathy (Disease Ontology:DOID:0060340); spermatogenic failure (Disease Ontology:DOID:0111910)", "pathway": " (mmu:66061); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "26200093", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. Required for proper retrograde ciliary transport., [UniProtKB, UniProtKB]; Tctex1d2 is a novel syntaxin 4 binding protein that functions as a negative regulator of GLUT4 plasma membrane translocation through inhibition of the Doc2b-syntaxin 4 interaction Erratum:[Endocrinology. 2017 Apr 1;158(4):1048. doi: 10.1210/en.2017-00141. PMID: 28380631], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005930 axoneme;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0060271 cilium assembly;GO:0007018 microtubule-based movement;GO:1902017 regulation of cilium assembly;GO:0035721 intraciliary retrograde transport;GO:1905799 regulation of intraciliary retrograde transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQ66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWF2-1", "uniprot_id": "TBB2B_MOUSE", "mass": 49953.0, "length": 445, "protein_name": "Tubulin beta-2B chain", "gene_name": "Tubb2b", "organism": "Mouse", "refseq_name": "tubulin beta-2B chain", "refseq_ac": "NP_076205", "gene_names_uniprotkb": "Tubb2b", "gene_names_refseq": "2410129E14Rik; Tubb2b; brdp", "protein_names_uniprotkb": "Tubulin beta-2B chain", "protein_names_refseq": "tubulin beta-2B chain", "tax_id": 10090, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); tubulinopathy (Disease Ontology:DOID:0112227); facial paralysis (Disease Ontology:DOID:13934)", "pathway": " (mmu:73710); (R-MMU-190840); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3371497); (R-MMU-380320); (R-MMU-437239); (R-MMU-5610787); (R-MMU-5620920); (R-MMU-5620924); (R-MMU-5626467); (R-MMU-5663220); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811436); (R-MMU-68877); (R-MMU-8852276); (R-MMU-8955332); (R-MMU-9646399); (R-MMU-9648025); (R-MMU-9668328); (R-MMU-983189); (R-MMU-9833482)", "pathway_count": 24, "publication_count": 17, "publication_id_list": "15890843;19465910;19524510;20665223;22645316;23897886;25428506;25605945;30084848;30779550;31386652;33300544;33414192;33725478;34105348;35820727;36583994", "class_list": "", "function": "Study shows that loss of Tubb2a or Tubb2b does not impair survival but does lead to relatively mild cortical malformation phenotypes. In contrast, loss of Tuba1a is perinatal lethal and leads to significant forebrain dysmorphology. The ability of the mouse to survive in the absence of some tubulin genes known to cause disease in humans suggests future intervention strategies for these devastating tubulinopathy diseases. Publication Status: Online-Only, [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TG26", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0001764 neuron migration;GO:0021987 cerebral cortex development;GO:0050804 modulation of chemical synaptic transmission;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9CWF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CY24-1", "uniprot_id": "T179B_MOUSE", "mass": 23528.0, "length": 219, "protein_name": "Transmembrane protein 179B", "gene_name": "Tmem179b", "organism": "Mouse", "refseq_name": "transmembrane protein 179B precursor", "refseq_ac": "NP_080601", "gene_names_uniprotkb": "Tmem179b", "gene_names_refseq": "0610031L02Rik; 1500003K22Rik; 1810059G22Rik; Tmem179b", "protein_names_uniprotkb": "Transmembrane protein 179B", "protein_names_refseq": "transmembrane protein 179B precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:67706); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8L7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0016020 membrane;GO:0016607 nuclear speck", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CY24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0R2-1", "uniprot_id": "SYTC_MOUSE", "mass": 83356.0, "length": 722, "protein_name": "Threonine--tRNA ligase 1, cytoplasmic", "gene_name": "Tars1", "organism": "Mouse", "refseq_name": "threonine--tRNA ligase 1, cytoplasmic", "refseq_ac": "NP_149065", "gene_names_uniprotkb": "Tars1; Tars", "gene_names_refseq": "D15Wsu59e; Tars1; Tars; ThrRS", "protein_names_uniprotkb": "Threonine--tRNA ligase 1, cytoplasmic; 6.1.1.3; ThrRS; Threonine--tRNA ligase, cytoplasmic; Threonyl-tRNA synthetase 1; Threonyl-tRNA synthetase", "protein_names_refseq": "threonine--tRNA ligase 1, cytoplasmic; threonine--tRNA ligase, cytoplasmic; threonyl-tRNA synthetase, cytoplasmic", "tax_id": 10090, "disease": "nonphotosensitive trichothiodystrophy (Disease Ontology:DOID:0111867); nonphotosensitive trichothiodystrophy 7 (Disease Ontology:DOID:0111870); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:110960)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;16139798;18034455;18250455;21183079;21750661;23806337;26495903;29579307;31219806;34428180;34569098;37453647;37507081", "class_list": "", "function": "A non-translational role of threonyl-tRNA synthetase in regulating JNK signaling during myogenic differentiation., [RefSeq, PubMed]; Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TL42;Q7TMQ2;Q8BMI6;Q9CX03", "ec_number_list": "6.1.1.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004829 threonine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006435 threonyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9D0R2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1R1-1", "uniprot_id": "T126B_MOUSE", "mass": 25444.0, "length": 230, "protein_name": "Complex I assembly factor TMEM126B, mitochondrial", "gene_name": "Tmem126b", "organism": "Mouse", "refseq_name": "complex I assembly factor TMEM126B, mitochondrial", "refseq_ac": "NP_081010", "gene_names_uniprotkb": "Tmem126b", "gene_names_refseq": "1110001A23Rik; Tmem126b", "protein_names_uniprotkb": "Complex I assembly factor TMEM126B, mitochondrial; Transmembrane protein 126B", "protein_names_refseq": "complex I assembly factor TMEM126B, mitochondrial", "tax_id": 10090, "disease": "nuclear type mitochondrial complex I deficiency 29 (Disease Ontology:DOID:0112084)", "pathway": " (mmu:68472); (R-MMU-6799198)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "22872234;30580996;31178133;31219806;34428180;36210013", "class_list": "", "function": "As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. Participates in constructing the membrane arm of complex I., [UniProtKB, UniProtKB]; TMEM126B has a role in protecting against heart injury via improving mitochondrial function in high fat diet-induced mice, [RefSeq, PubMed]; This study identified Tmem126b as a positive regulator for the progression of chronic kidney disease induced by high-fat diet through meditating Nrf-2 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0160295 mitochondrial complex I intermediate assembly complex", "go_biological_process": "GO:0032094 response to food;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D1R1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2F5-1", "uniprot_id": "STPG1_MOUSE", "mass": 37499.0, "length": 341, "protein_name": "O(6)-methylguanine-induced apoptosis 2", "gene_name": "Stpg1", "organism": "Mouse", "refseq_name": "O(6)-methylguanine-induced apoptosis 2 isoform a", "refseq_ac": "NP_084465", "gene_names_uniprotkb": "Stpg1", "gene_names_refseq": "4930403G18Rik; 4930555I21Rik; Mapo2; Stpg1", "protein_names_uniprotkb": "O(6)-methylguanine-induced apoptosis 2; MAPO2; Sperm-tail PG-rich repeat-containing protein 1", "protein_names_refseq": "O(6)-methylguanine-induced apoptosis 2 isoform a; O(6)-methylguanine-induced apoptosis 2; O6-methylguanine-induced apoptosis 2; UPF0490 protein C1orf201 homolog; sperm-tail PG-rich repeat-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:78806)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23028632", "class_list": "", "function": "MAPO2 gene product might positively contribute to the induction of apoptosis triggered by O-methylguanine, [RefSeq, PubMed]; May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D2F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D342-1", "uniprot_id": "T170A_MOUSE", "mass": 15224.0, "length": 144, "protein_name": "Transmembrane protein 170A", "gene_name": "Tmem170a", "organism": "Mouse", "refseq_name": "transmembrane protein 170A isoform 1", "refseq_ac": "NP_080057", "gene_names_uniprotkb": "Tmem170a; D8Bwg1414e; Tmem170", "gene_names_refseq": "9030409E16Rik; D8Bwg1414e; Tmem170a; Tmem170", "protein_names_uniprotkb": "Transmembrane protein 170A", "protein_names_refseq": "transmembrane protein 170A isoform 1; transmembrane protein 170A", "tax_id": 10090, "disease": "", "pathway": " (mmu:66817)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6H6Q8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0006998 nuclear envelope organization;GO:0051292 nuclear pore complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D342-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERC3-1", "uniprot_id": "SRTD3_MOUSE", "mass": 21935.0, "length": 197, "protein_name": "SERTA domain-containing protein 3", "gene_name": "Sertad3", "organism": "Mouse", "refseq_name": "SERTA domain-containing protein 3", "refseq_ac": "NP_573473", "gene_names_uniprotkb": "Sertad3; Rbt1", "gene_names_refseq": "D1Mgi51; Rbt1; Sei3; Sertad3", "protein_names_uniprotkb": "SERTA domain-containing protein 3; RPA-binding trans-activator; Replication protein-binding trans-activator", "protein_names_refseq": "RPA-binding trans-activator; SERTA domain-containing protein 3; replication protein binding trans-activator", "tax_id": 10090, "disease": "", "pathway": " (mmu:170742)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "20484733;25605945;27802388;28750197;31219806;33147462;34203471;34428180;36210013", "class_list": "", "function": "Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms (By similarity). Plays a role in the late phase response of TLR-induced immune effector expression (PubMed:28750197). Strong transcriptional coactivator (By similarity)., [UniProtKB, PubMed, UniProtKB]; Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045087 innate immune response;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9ERC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0F7-1", "uniprot_id": "SYUG_MOUSE", "mass": 13160.0, "length": 123, "protein_name": "Gamma-synuclein", "gene_name": "Sncg", "organism": "Mouse", "refseq_name": "gamma-synuclein", "refseq_ac": "NP_035560", "gene_names_uniprotkb": "Sncg; Persyn", "gene_names_refseq": "Sncg; persyn", "protein_names_uniprotkb": "Gamma-synuclein; Persyn", "protein_names_refseq": "gamma-synuclein", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); pancreatic cancer (Disease Ontology:DOID:1793); pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981); retinoblastoma (Disease Ontology:DOID:768); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (mmu:20618)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10051410;16392033;20798282;22517741;32848054;37507081;40021952;40885482;9801372;9925745", "class_list": "", "function": "Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 11, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding;GO:1903136 cuprous ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0050808 synapse organization;GO:0007268 chemical synaptic transmission;GO:0014059 regulation of dopamine secretion;GO:0046928 regulation of neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9Z0F7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVA4-1", "uniprot_id": "TAGL2_MOUSE", "mass": 22395.0, "length": 199, "protein_name": "Transgelin-2", "gene_name": "Tagln2", "organism": "Mouse", "refseq_name": "transgelin-2", "refseq_ac": "NP_848713", "gene_names_uniprotkb": "Tagln2; Kiaa0120", "gene_names_refseq": "2700094C18Rik; SM22beta; Sm22B; Sm22a; Tagln2", "protein_names_uniprotkb": "Transgelin-2; SM22-beta", "protein_names_refseq": "SM22-beta; transgelin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:21346); (R-MMU-114608)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;12049783;17242355;18250455;21183079;21540332;21750661;24129315;25153642;25428506;25605945;26495903;26740625;27802388;28528544;30084848;31219806;31361958;33982775;34428180;36288343;37453647", "class_list": "", "function": "MicroRNA133b alleviates doxorubicininduced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIB8;Q6A0C6;Q78ZX2;Q91VU2", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q9WVA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P86176-1", "uniprot_id": "TIGIT_MOUSE", "mass": 26959.0, "length": 249, "protein_name": "T-cell immunoreceptor with Ig and ITIM domains", "gene_name": "Tigit", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tigit; Vstm3", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell immunoreceptor with Ig and ITIM domains; V-set and transmembrane domain-containing protein 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:100043314)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21199897;21750661;31219806;32782141", "class_list": "", "function": "Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades. In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway. Also acts as a receptor for NECTIN4 to inhibit NK cell cytotoxicity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0032695 negative regulation of interleukin-12 production;GO:0045953 negative regulation of natural killer cell mediated cytotoxicity;GO:0032733 positive regulation of interleukin-10 production;GO:0050868 negative regulation of T cell activation;GO:0042267 natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P86176-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q497K7-1", "uniprot_id": "TM247_MOUSE", "mass": 23971.0, "length": 211, "protein_name": "Transmembrane protein 247", "gene_name": "Tmem247", "organism": "Mouse", "refseq_name": "transmembrane protein 247 isoform 2", "refseq_ac": "NP_001264909", "gene_names_uniprotkb": "Tmem247", "gene_names_refseq": "1700090G07Rik; Tmem247", "protein_names_uniprotkb": "Transmembrane protein 247", "protein_names_refseq": "transmembrane protein 247 isoform 2; transmembrane protein ENSP00000343375 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:78469)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVQ7;Q9CU05", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q497K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TBN1-1", "uniprot_id": "TM248_MOUSE", "mass": 35041.0, "length": 314, "protein_name": "Transmembrane protein 248", "gene_name": "Tmem248", "organism": "Mouse", "refseq_name": "transmembrane protein 248", "refseq_ac": "NP_001074863", "gene_names_uniprotkb": "Tmem248", "gene_names_refseq": "0610007L01Rik; A930023A16Rik; G430067H08Rik; Tmem248", "protein_names_uniprotkb": "Transmembrane protein 248", "protein_names_refseq": "UPF0458 protein C7orf42 homolog; transmembrane protein 248", "tax_id": 10090, "disease": "", "pathway": " (mmu:71667)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIB2;Q9DD07", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3TBN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4D4-1", "uniprot_id": "TKTL2_MOUSE", "mass": 68447.0, "length": 627, "protein_name": "Transketolase-like protein 2", "gene_name": "Tktl2", "organism": "Mouse", "refseq_name": "transketolase-like protein 2", "refseq_ac": "NP_001258503", "gene_names_uniprotkb": "Tktl2", "gene_names_refseq": "4933401I19Rik; Tktl2", "protein_names_uniprotkb": "Transketolase-like protein 2; 2.2.1.1", "protein_names_refseq": "transketolase-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74419)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RSH3", "ec_number_list": "2.2.1.1", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030976 thiamine pyrophosphate binding;GO:0004802 transketolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009052 pentose-phosphate shunt, non-oxidative branch", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D4D4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WQ3-1", "uniprot_id": "SYYC_MOUSE", "mass": 59105.0, "length": 528, "protein_name": "Tyrosine--tRNA ligase, cytoplasmic", "gene_name": "Yars1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Yars1; Yars", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine--tRNA ligase, cytoplasmic; 6.1.1.1; TyrRS; Tyrosyl-tRNA synthetase", "protein_names_refseq": "", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease dominant intermediate C (Disease Ontology:DOID:0110199); multisystem proteinopathy (Disease Ontology:DOID:070355); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); cancer (Disease Ontology:DOID:162); neuropathy (Disease Ontology:DOID:870)", "pathway": " (mmu:107271)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;25533949;30059200;33725478;34428180;34887587;37453647;40684658", "class_list": "", "function": "Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity (By similarity). Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:25533949)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEC8;Q3U9A1;Q3UTA7;Q8BVT2;Q8C183", "ec_number_list": "6.1.1.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0036094 small molecule binding;GO:0004831 tyrosine-tRNA ligase activity;GO:0004812 aminoacyl-tRNA ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0042594 response to starvation;GO:0070212 protein poly-ADP-ribosylation;GO:0006437 tyrosyl-tRNA aminoacylation;GO:0006418 tRNA aminoacylation for protein translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91WQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U0Y2-1", "uniprot_id": "TM35B_MOUSE", "mass": 16223.0, "length": 150, "protein_name": "Transmembrane protein 35B", "gene_name": "Tmem35b", "organism": "Mouse", "refseq_name": "transmembrane protein 35B precursor", "refseq_ac": "NP_001092789", "gene_names_uniprotkb": "Tmem35b; Gm12942; Zmym6nb", "gene_names_refseq": "Gm12942; Tmem35b; Zmym6nb", "protein_names_uniprotkb": "Transmembrane protein 35B; ZMYM6 neighbor protein", "protein_names_refseq": "ZMYM6 neighbor protein; transmembrane protein 35B precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039968)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A7U4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3U0Y2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CCT4-1", "uniprot_id": "TCAL5_MOUSE", "mass": 22038.0, "length": 200, "protein_name": "Transcription elongation factor A protein-like 5", "gene_name": "Tceal5", "organism": "Mouse", "refseq_name": "transcription elongation factor A protein-like 5", "refseq_ac": "NP_808587", "gene_names_uniprotkb": "Tceal5", "gene_names_refseq": "6430401A05Rik; Tceal5", "protein_names_uniprotkb": "Transcription elongation factor A protein-like 5; TCEA-like protein 5; Transcription elongation factor S-II protein-like 5", "protein_names_refseq": "TCEA-like protein 5; transcription elongation factor A protein-like 5; transcription elongation factor S-II protein-like 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:331532)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;27580811;30059200;35216152", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]; Sufficient to increase the growth rate of pituitary progenitors, suggesting a role as a proto-oncogene, [RefSeq, PubMed]; Tceal5 and Tceal7 Function in C2C12 Myogenic Differentiation via Exosomes in Fetal Bovine Serum. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q497R6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CCT4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23881-1", "uniprot_id": "TCEA3_MOUSE", "mass": 38850.0, "length": 347, "protein_name": "Transcription elongation factor A protein 3", "gene_name": "Tcea3", "organism": "Mouse", "refseq_name": "transcription elongation factor A protein 3", "refseq_ac": "NP_035672", "gene_names_uniprotkb": "Tcea3; Tfiish", "gene_names_refseq": "S-II; SII-K1; Tcea3", "protein_names_uniprotkb": "Transcription elongation factor A protein 3; Transcription elongation factor S-II protein 3; Transcription elongation factor TFIIS.h", "protein_names_refseq": "tissue-specific transcription factor S-II; transcription elongation factor A protein 3; transcription elongation factor S-II protein 3; transcription elongation factor TFIIS.h", "tax_id": 10090, "disease": "", "pathway": " (mmu:21401)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "1917889;21183079;21750661;23169579;24397209;25428506;30084848;30623413;31158246;31599954;34428180;9790746", "class_list": "", "function": "Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus., [UniProtKB]; TCEA3 is a required co-factor for myogenic regulatory factors driven gene expression during myogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Tcea3 critically regulates pluripotent differentiation of mouse embryonic stem cells as a molecular rheostat of Lefty1-Nodal-Smad2 signaling., [RefSeq, PubMed]; Vascular endothelial growth factor A and VEGFC, major transcription factors that regulate vasculogenesis, are activated in Tcea3 knocked down mESCs, [RefSeq, PubMed]; Which is located in the cytoplasm and also promotes cell differentiation. Collectively, our results indicate that TCEA3 promotes cell differentiation by interacting with ANXA1 and affecting transforming growth factor-b signaling pathways, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AW46;O88710;Q9CTZ8;Q9DCZ5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006368 transcription elongation by RNA polymerase II;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P23881-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AVH7-1", "uniprot_id": "TBD2A_MOUSE", "mass": 104260.0, "length": 922, "protein_name": "TBC1 domain family member 2A", "gene_name": "Tbc1d2", "organism": "Mouse", "refseq_name": "TBC1 domain family member 2A", "refseq_ac": "NP_941066", "gene_names_uniprotkb": "Tbc1d2; Tbc1d2a", "gene_names_refseq": "A630005A06Rik; Gm1037; PARIS-1; PARIS1; Tbc1d2", "protein_names_uniprotkb": "TBC1 domain family member 2A", "protein_names_refseq": "TBC1 domain family member 2A; likely ortholog of H. sapiens TBC1 domain family, member 2 (TBC1D2)", "tax_id": 10090, "disease": "", "pathway": " (mmu:381605); (R-MMU-8854214)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "27793976;31219806;34428180;34887587", "class_list": "", "function": "Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity)., [UniProtKB]; Vps34 has a previously unknown role in regulating Rab7 activity and late endosomal trafficking., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFW9;Q8BYB1", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0045296 cadherin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B1AVH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RWW0-1", "uniprot_id": "TAGAP_MOUSE", "mass": 78920.0, "length": 714, "protein_name": "T-cell activation Rho GTPase-activating protein", "gene_name": "Tagap", "organism": "Mouse", "refseq_name": "T-cell activation Rho GTPase-activating protein", "refseq_ac": "NP_666080", "gene_names_uniprotkb": "Tagap", "gene_names_refseq": "2610315E15Rik; TRD; Tagap; Tcd-1; Tcd1a; Tcd1; tcs-1; tcs1", "protein_names_uniprotkb": "T-cell activation Rho GTPase-activating protein; T-cell activation GTPase-activating protein", "protein_names_refseq": "T-cell activation GTPase-activating protein 1; T-cell activation Rho GTPase-activating protein; t-complex distorter 1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:72536); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "16116428;29017772;29895617;30059200;32312989;37744350", "class_list": "", "function": "Loss of Tagap in mice suppressed the sema3E- and plexin-D1-mediated release of thymocytes that adhered within the cortex through beta1-containing integrins. This suppression led to the impaired translocation of thymocytes from the cortex to the medulla and resulted in the formation of ectopic medullary structures within the thymic cortex leading to autoimmune disorders. Publication Status: Online-Only, [RefSeq, PubMed]; May function as a GTPase-activating protein. May play a role in transmission ratio distortion (TRD) in mouse, in which heterozygous males for t-locus transmit their t-carrying chromosome to 95% or more of their offspring., [UniProtKB, PubMed]; TAGAP expression influences CD4+ T cell differentiation, immune infiltration, and cytotoxicity in LUAD through the STAT pathway: implications for immunotherapy. Publication Status: Online-Only, [RefSeq, PubMed]; TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response. Publication Status: Online-Only, [RefSeq, PubMed]; These findings indicate that increased TAGAP expression is a distinguishing feature of inflammatory disease and further highlight the role of TAGAP in rheumatoid arthritis susceptibility., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2L9;Q920D6", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0051607 defense response to virus;GO:0035023 regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B2RWW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHW1-1", "uniprot_id": "THAP1_MOUSE", "mass": 24611.0, "length": 210, "protein_name": "THAP domain-containing protein 1", "gene_name": "Thap1", "organism": "Mouse", "refseq_name": "THAP domain-containing protein 1", "refseq_ac": "NP_950243", "gene_names_uniprotkb": "Thap1", "gene_names_refseq": "4833431A01Rik; Thap1", "protein_names_uniprotkb": "THAP domain-containing protein 1", "protein_names_refseq": "THAP domain-containing protein 1", "tax_id": 10090, "disease": "torsion dystonia 6 (Disease Ontology:DOID:0090039)", "pathway": " (mmu:73754)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20200153;21750661;28579396;28697333;34802187", "class_list": "", "function": "DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Pharmacological perturbation reveals deficits in D2 receptor responses in Thap1 null mice., [RefSeq, PubMed]; These studies establish a role for THAP1 transcriptional regulation at the inception of myelination and implicate abnormal timing of myelination in the pathogenesis of childhood-onset dystonia., [RefSeq, PubMed]; Wild-type THAP1 regulates embryonic stem cell (ESC) potential, survival, and proliferation. Loss of THAP1 or replacement with a disease-causing mutation results in an enhanced rate of cell death, prolongs Nanog, Prdm14, and/or Rex1 expression upon differentiation, and results in failure to upregulate ectodermal genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0016605 PML body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CHW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56841-1", "uniprot_id": "TCLB2_MOUSE", "mass": 13672.0, "length": 117, "protein_name": "Protein TCL1B2", "gene_name": "Tcl1b2", "organism": "Mouse", "refseq_name": "protein TCL1B2", "refseq_ac": "NP_038803", "gene_names_uniprotkb": "Tcl1b2", "gene_names_refseq": "Tcl1b2", "protein_names_uniprotkb": "Protein TCL1B2", "protein_names_refseq": "protein TCL1B2", "tax_id": 10090, "disease": "", "pathway": " (mmu:27381)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10588720;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P56841-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6QR59-1", "uniprot_id": "TCAF3_MOUSE", "mass": 102243.0, "length": 914, "protein_name": "TRPM8 channel-associated factor 3", "gene_name": "Tcaf3", "organism": "Mouse", "refseq_name": "TRPM8 channel-associated factor 3", "refseq_ac": "NP_981933", "gene_names_uniprotkb": "Tcaf3; Eapa2; Fam115e", "gene_names_refseq": "Eapa2; Fam115e; Tcaf3", "protein_names_uniprotkb": "TRPM8 channel-associated factor 3; Experimental autoimmune prostatitis antigen 2", "protein_names_refseq": "TRPM8 channel-associated factor 3; experimental autoimmune prostatitis antigen 2; family with sequence similarity 115, member E; protein FAM115E", "tax_id": 10090, "disease": "", "pathway": " (mmu:403088)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16223778;17003280;21750661", "class_list": "", "function": "May play a role in the regulation of the cation channel TRPM8 activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0090314 positive regulation of protein targeting to membrane;GO:0010360 negative regulation of anion channel activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6QR59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922P8-1", "uniprot_id": "T132A_MOUSE", "mass": 110239.0, "length": 1018, "protein_name": "Transmembrane protein 132A", "gene_name": "Tmem132a", "organism": "Mouse", "refseq_name": "transmembrane protein 132A isoform 1 precursor", "refseq_ac": "NP_598565", "gene_names_uniprotkb": "Tmem132a; Kiaa1583", "gene_names_refseq": "6720481D13Rik; Hspa5bp1; Orai1; Tmem132a", "protein_names_uniprotkb": "Transmembrane protein 132A; HSPA5-binding protein 1", "protein_names_refseq": "HSPA5-binding protein 1; heat shock 70kDa protein 5 binding protein 1; heat shock protein 5 binding protein 1; transmembrane protein 132A isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:98170); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22821197;25926156;30899004;33725478;35950911;37390294;37828378", "class_list": "", "function": "Markedly attenuated the levels of TMEM132A mRNA., [RefSeq, PubMed]; May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity)., [UniProtKB]; TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration., [RefSeq, PubMed]; TMEM132A regulates mouse hindgut morphogenesis and caudal development., [RefSeq, PubMed]; The novel cell-surface localized glycoprotein, TMEM132A, is regulated by several factors, including GRP78, Sar1, and intracellular calcium, in a post-transcriptional manner., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZF9;Q8BX93", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043069 negative regulation of programmed cell death;GO:0042177 negative regulation of protein catabolic process;GO:0061357 positive regulation of Wnt protein secretion;GO:0030177 positive regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q922P8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6GQT5-1", "uniprot_id": "T151A_MOUSE", "mass": 51312.0, "length": 468, "protein_name": "Transmembrane protein 151A", "gene_name": "Tmem151a", "organism": "Mouse", "refseq_name": "transmembrane protein 151A", "refseq_ac": "NP_001001885", "gene_names_uniprotkb": "Tmem151a; Gm961; Tmem151", "gene_names_refseq": "Gm30627; Gm961; Tmem151a; Tmem151", "protein_names_uniprotkb": "Transmembrane protein 151A", "protein_names_refseq": "transmembrane protein 151A; transmembrane protein 151", "tax_id": 10090, "disease": "episodic kinesigenic dyskinesia 3 (Disease Ontology:DOID:0060944)", "pathway": " (mmu:381199)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34518509;34711800", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6GQT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PDZ2-1", "uniprot_id": "TAF1C_MOUSE", "mass": 92023.0, "length": 836, "protein_name": "TATA box-binding protein-associated factor RNA polymerase I subunit C", "gene_name": "Taf1c", "organism": "Mouse", "refseq_name": "TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 1", "refseq_ac": "NP_067416", "gene_names_uniprotkb": "Taf1c", "gene_names_refseq": "Taf1c; Tafi95; mTAFI95", "protein_names_uniprotkb": "TATA box-binding protein-associated factor RNA polymerase I subunit C; RNA polymerase I-specific TBP-associated factor 95 kDa; TAFI95; TATA box-binding protein-associated factor 1C; TBP-associated factor 1C; Transcription initiation factor SL1/TIF-IB subunit C", "protein_names_refseq": "RNA polymerase I-specific TBP-associated factor 95 kDa; TATA box binding protein (Tbp)-associated factor, RNA polymerase I, C; TATA box-binding protein-associated factor 1C; TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 1; TATA box-binding protein-associated factor RNA polymerase I subunit C; TBP-associated factor 1C; TBP-associated factor RNA polymerase I 95 kDa; transcription factor TAFI95; transcription initiation factor SL1/TIF-IB subunit C", "tax_id": 10090, "disease": "", "pathway": " (mmu:21341); (R-MMU-5250924); (R-MMU-73762); (R-MMU-73772); (R-MMU-73863)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "12393749;21750661;25428506;26495903;31219806;9050847;9451438", "class_list": "", "function": "Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P97359;Q3U3B6;Q8BN54", "ec_number_list": "", "go_molecular_function": "GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding;GO:0001181 RNA polymerase I general transcription initiation factor activity", "go_cellular_component": "GO:0005668 RNA polymerase transcription factor SL1 complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0000120 RNA polymerase I transcription regulator complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6PDZ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810U2-1", "uniprot_id": "TDM1A_MOUSE", "mass": 34794.0, "length": 305, "protein_name": "Transmembrane epididymal protein 1A", "gene_name": "Teddm1a", "organism": "Mouse", "refseq_name": "transmembrane epididymal protein 1A", "refseq_ac": "NP_839975", "gene_names_uniprotkb": "Teddm1a; Epdd1; Teddm1-1; Teddm1", "gene_names_refseq": "Epdd1; Teddm1a; Teddm1; e9-1", "protein_names_uniprotkb": "Transmembrane epididymal protein 1A; Transmembrane epididymal protein 1-1", "protein_names_refseq": "epididymal protein e9-1; transmembrane epididymal protein 1-1; transmembrane epididymal protein 1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:240819)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ62;Q2VP90", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q810U2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99ME7-1", "uniprot_id": "TBX19_MOUSE", "mass": 48037.0, "length": 446, "protein_name": "T-box transcription factor TBX19", "gene_name": "Tbx19", "organism": "Mouse", "refseq_name": "T-box transcription factor TBX19", "refseq_ac": "NP_114394", "gene_names_uniprotkb": "Tbx19; Tpit", "gene_names_refseq": "D1Ertd754e; Tbx19; Tpit", "protein_names_uniprotkb": "T-box transcription factor TBX19; T-box factor, pituitary; T-box protein 19", "protein_names_refseq": "T-box factor, pituitary; T-box protein 19; T-box transcription factor TBX19", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); adrenocorticotropic hormone deficiency (Disease Ontology:DOID:0080150); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (mmu:83993)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11290323;11447259;11916612;12651888;12651892;21750661;25428506", "class_list": "", "function": "Review. Association of 2 mutations with an ACTH deficiency is consistent with the role of tbx19 in differentiation of POMC cells. Review article, [RefSeq, PubMed]; TPIT has a role in expression of the pro-opiomelanocortin gene and terminal differentiation of the pituitary corticotroph lineage, and its mutation causes early onset pituitary ACTH deficiency, [RefSeq, PubMed]; This gene encodes a member of a family of transcription factors containing a characteristic T-box DNA-binding domain. The encoded protein promotes expression of the pro-opiomelanocortin (POMC) gene, which is important for the differentiation of cells in the pituitary gland. [provided by RefSeq, Mar 2013]., [RefSeq]; Tpit has a role as a negative regulator of gonadotroph differentiation in developing mouse, [RefSeq, PubMed]; Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBH2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99ME7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QVN7-1", "uniprot_id": "TCEA2_MOUSE", "mass": 33663.0, "length": 299, "protein_name": "Transcription elongation factor A protein 2", "gene_name": "Tcea2", "organism": "Mouse", "refseq_name": "transcription elongation factor A protein 2 isoform a", "refseq_ac": "NP_033352", "gene_names_uniprotkb": "Tcea2", "gene_names_refseq": "S-II-T1; SII-T1; Tcea2; Tceat", "protein_names_uniprotkb": "Transcription elongation factor A protein 2; Protein S-II-T1; Testis-specific S-II; Transcription elongation factor S-II protein 2; Transcription elongation factor TFIIS.l", "protein_names_refseq": "testis-specific S-II; transcription elongation factor A protein 2 isoform a; transcription elongation factor A protein 2; transcription elongation factor S-II protein 2; transcription elongation factor TFIIS.l", "tax_id": 10090, "disease": "", "pathway": " (mmu:21400)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;30779550;8641458;9133631;9799847", "class_list": "", "function": "Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08667", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0036064 ciliary basal body", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QVN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C4J7-1", "uniprot_id": "TBL3_MOUSE", "mass": 88266.0, "length": 801, "protein_name": "Transducin beta-like protein 3", "gene_name": "Tbl3", "organism": "Mouse", "refseq_name": "transducin beta-like protein 3", "refseq_ac": "NP_663371", "gene_names_uniprotkb": "Tbl3", "gene_names_refseq": "9430070M15Rik; Tbl3", "protein_names_uniprotkb": "Transducin beta-like protein 3", "protein_names_refseq": "transducin beta-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:213773); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;25153642;31219806;34428180;36210013", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNP3;Q3UDS9;Q8VE90", "ec_number_list": "", "go_molecular_function": "GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C4J7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q571K4-1", "uniprot_id": "TAB3_MOUSE", "mass": 79029.0, "length": 716, "protein_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3", "gene_name": "Tab3", "organism": "Mouse", "refseq_name": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3", "refseq_ac": "NP_080005", "gene_names_uniprotkb": "Tab3; Kiaa4135; Map3k7ip3", "gene_names_refseq": "4921526G09Rik; Map3k7ip3; Tab3; mKIAA4135", "protein_names_uniprotkb": "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; TAB-3; TAK1-binding protein 3; TGF-beta-activated kinase 1-binding protein 3", "protein_names_refseq": "TAK1-binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3; mitogen-activated protein kinase kinase kinase 7-interacting protein 3", "tax_id": 10090, "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:66724); (R-MMU-168638); (R-MMU-2871837); (R-MMU-445989); (R-MMU-450302); (R-MMU-450321); (R-MMU-5357956); (R-MMU-5607764); (R-MMU-9020702); (R-MMU-937042); (R-MMU-937072); (R-MMU-9645460); (R-MMU-975163)", "pathway_count": 13, "publication_count": 14, "publication_id_list": "19927120;21750661;22517741;22645316;22826440;28462515;30016717;30084848;32782141;32848054;34203471;36852467;40021952;40885482", "class_list": "", "function": "Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1., [UniProtKB, UniProtKB]; Findings indicate that the absence of TAB3 plays a harmful role in ischemic heart disease, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0043130 ubiquitin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0042742 defense response to bacterium;GO:0007249 canonical NF-kappaB signal transduction;GO:0038061 non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q571K4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFK2-1", "uniprot_id": "TF3B_MOUSE", "mass": 73799.0, "length": 676, "protein_name": "Transcription factor IIIB 90 kDa subunit", "gene_name": "Brf1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Brf1", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor IIIB 90 kDa subunit; B-related factor 1; BRF-1; TFIIIB90; mTFIIIB90", "protein_names_refseq": "", "tax_id": 10090, "disease": "fibroma (Disease Ontology:DOID:0050871); cerebellofaciodental syndrome (Disease Ontology:DOID:0080898); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:72308); (R-MMU-76061); (R-MMU-76066)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;34428180", "class_list": "", "function": "General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017025 TBP-class protein binding;GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding;GO:0000995 RNA polymerase III general transcription initiation factor activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0000126 transcription factor TFIIIB complex", "go_biological_process": "GO:0043488 regulation of mRNA stability;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0006383 transcription by RNA polymerase III;GO:0006352 DNA-templated transcription initiation;GO:0070897 transcription preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CFK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDR5-1", "uniprot_id": "TM267_MOUSE", "mass": 24152.0, "length": 215, "protein_name": "Transmembrane protein 267", "gene_name": "Tmem267", "organism": "Mouse", "refseq_name": "transmembrane protein 267", "refseq_ac": "NP_001034333", "gene_names_uniprotkb": "Tmem267; Gm7120", "gene_names_refseq": "EG633640; Gm7120; Tmem267", "protein_names_uniprotkb": "Transmembrane protein 267", "protein_names_refseq": "transmembrane protein 267; transmembrane protein C5orf28 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:633640)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYJ5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VDR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88968-1", "uniprot_id": "TCO2_MOUSE", "mass": 47586.0, "length": 430, "protein_name": "Transcobalamin-2", "gene_name": "Tcn2", "organism": "Mouse", "refseq_name": "transcobalamin-2 precursor", "refseq_ac": "NP_001123930", "gene_names_uniprotkb": "Tcn2", "gene_names_refseq": "Tcn-2; Tcn2", "protein_names_uniprotkb": "Transcobalamin-2; TC II; TC-2; TCII; Transcobalamin II", "protein_names_refseq": "TC II; TC-2; TCII; transcobalamin II; transcobalamin-2 precursor", "tax_id": 10090, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731); transcobalamin II deficiency (Disease Ontology:DOID:0050818); megaloblastic anemia (Disease Ontology:DOID:13382); Parkinson's disease (Disease Ontology:DOID:14330); cryoglobulinemia (Disease Ontology:DOID:2917); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:21452); (R-MMU-9758890)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "25428506;27802388;33803025;34428180", "class_list": "", "function": "Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter. Publication Status: Online-Only, [RefSeq, PubMed]; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TD34;Q3UP69;Q5SQ21", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0031419 cobalamin binding;GO:0140355 cargo receptor ligand activity;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0015889 cobalamin transport;GO:0006824 cobalt ion transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88968-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01851-1", "uniprot_id": "TCB2_MOUSE", "mass": 19297.0, "length": 173, "protein_name": "T-cell receptor beta-2 chain C region", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell receptor beta-2 chain C region", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "12015151;25605945;34428180;6330561;6336329", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0042105 alpha-beta T cell receptor complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P01851-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06335-1", "uniprot_id": "TCC4_MOUSE", "mass": 22065.0, "length": 190, "protein_name": "T-cell receptor gamma chain C region 5/10-13", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell receptor gamma chain C region 5/10-13", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3486244", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P06335-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48776-1", "uniprot_id": "T23O_MOUSE", "mass": 47756.0, "length": 406, "protein_name": "Tryptophan 2,3-dioxygenase", "gene_name": "Tdo2", "organism": "Mouse", "refseq_name": "tryptophan 2,3-dioxygenase", "refseq_ac": "NP_064295", "gene_names_uniprotkb": "Tdo2; Tdo", "gene_names_refseq": "TDO; TO; Tdo2; chky", "protein_names_uniprotkb": "Tryptophan 2,3-dioxygenase; 1.13.11.11; TDO; TO; TRPO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; Tryptophan pyrrolase; Tryptophanase", "protein_names_refseq": "TRPO; tdo variant1; tdo variant2; tryptamin 2,3-dioxygenase; tryptophan 2,3-dioxygenase; tryptophan oxygenase; tryptophan pyrrolase; tryptophanase", "tax_id": 10090, "disease": "familial hypertryptophanemia (Disease Ontology:DOID:0111703); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:56720); (R-MMU-71240)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14714090;34428180;34529208;37453647", "class_list": "", "function": "A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice., [RefSeq, PubMed]; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety., [UniProtKB, HAMAP]; No relationship was found between alcohol consumption, Tdo2 activity, and single nucleotide substitution in intron 6 of the Tdo2 gene assoiated with predisposition to alcoholism in humans., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.13.11.52;1.13.11.11;1.13.11.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016597 amino acid binding;GO:0020037 heme binding;GO:0019825 oxygen binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0045471 response to ethanol;GO:0051289 protein homotetramerization;GO:0006568 L-tryptophan metabolic process;GO:0051414 response to cortisol", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P48776-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56844-1", "uniprot_id": "TCLB4_MOUSE", "mass": 14123.0, "length": 120, "protein_name": "Protein TCL1B4", "gene_name": "Tcl1b4", "organism": "Mouse", "refseq_name": "protein TCL1B4 isoform 2", "refseq_ac": "NP_038802", "gene_names_uniprotkb": "Tcl1b4", "gene_names_refseq": "Tcl1b4", "protein_names_uniprotkb": "Protein TCL1B4", "protein_names_refseq": "protein TCL1B4 isoform 2; protein TCL1B4", "tax_id": 10090, "disease": "", "pathway": " (mmu:27380)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10588720", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P56844-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59530-1", "uniprot_id": "TA2R7_MOUSE", "mass": 35510.0, "length": 312, "protein_name": "Taste receptor type 2 member 7", "gene_name": "Tas2r7", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 7", "refseq_ac": "NP_954607", "gene_names_uniprotkb": "Tas2r7; Tas2r130; Tas2r6", "gene_names_refseq": "STC74; T2R30; Tas2r130; Tas2r30; Tas2r7; mt2r42", "protein_names_uniprotkb": "Taste receptor type 2 member 7; STC7-4; T2R30; T2R6; T2R7; mT2R42", "protein_names_refseq": "STC 7-4; STC7-4; T2R6; T2R7; taste receptor type 2 member 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:387355); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11696554;11854532;12139982;12581520;12679530;12920489", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VE81;Q7M726", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P59530-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61216-1", "uniprot_id": "TAF13_MOUSE", "mass": 14287.0, "length": 124, "protein_name": "Transcription initiation factor TFIID subunit 13", "gene_name": "Taf13", "organism": "Mouse", "refseq_name": "transcription initiation factor TFIID subunit 13", "refseq_ac": "NP_079720", "gene_names_uniprotkb": "Taf13; Taf2k", "gene_names_refseq": "1810004N01Rik; 2010309N11Rik; TAFII18; Taf13", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 13; TAF(II)18; TAFII-18; TAFII18; Transcription initiation factor TFIID 18 kDa subunit", "protein_names_refseq": "TAF(II)18; TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAF13 RNA polymerase II, TATA box-binding protein-associated factor; TAFII-18; TBP-associated factor, RNA polymerase II, K, 18kD; transcription initiation factor TFIID 18 kDa subunit; transcription initiation factor TFIID subunit 13", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 60 (Disease Ontology:DOID:0081222)", "pathway": " (mmu:99730); (R-MMU-674695); (R-MMU-6804756); (R-MMU-6807505); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "30084848", "class_list": "", "function": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVE8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0042789 mRNA transcription by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61216-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62340-1", "uniprot_id": "TBPL1_MOUSE", "mass": 20887.0, "length": 186, "protein_name": "TATA box-binding protein-like 1", "gene_name": "Tbpl1", "organism": "Mouse", "refseq_name": "TATA box-binding protein-like 1 isoform 1", "refseq_ac": "NP_035733", "gene_names_uniprotkb": "Tbpl1; Tlf; Tlp21; Tlp; Trf2; Trp", "gene_names_refseq": "4732475G08; STD; TLF; TRF2; TRP; Tbpl1; Tlp", "protein_names_uniprotkb": "TATA box-binding protein-like 1; 21 kDa TBP-like protein; TATA box-binding protein-related factor 2; TBP-like 1; TBP-like factor; TBP-related factor 2; TBP-related protein", "protein_names_refseq": "21 kDa TBP-like protein; TATA box binding protein-like protein; TATA box-binding protein-like 1 isoform 1; TATA box-binding protein-like protein 1; TATA box-binding protein-related factor 2; TBP-like 1; TBP-like factor; TBP-like protein 1; TBP-related factor 2; TBP-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:237336)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11352070;15767669;16412700;27576952;27680312;9889269", "class_list": "", "function": "Overexpression and knockdown of TLP revealed that the levels of muscle-specific myosin heavy chain and the myogenic transcription factor myogenin are downregulated by TLP. The proximal AT-rich sequence of the myogenin promoter is responsible for TLP-mediated transcriptional repression., [RefSeq, PubMed]; Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes (By similarity). Seems to also mediate the transcription of NF1. Does not bind the TATA box., [UniProtKB, PubMed, PubMed]; Role of TRF2 mRNA in male germ cells: In transgenic animals deficient in TRF2, spermatid development fails during early spermiogenesis with increased apoptosis and failure to develop testicular spermatozoa. Infertility phenotype in homozygote males., [RefSeq, PubMed]; Trf2 forms a stable complex with TFIIA or the testis expressed paralogue ALF chaperoned in the cytoplasm by heat shock proteins. It is recruited to active haploid cell promoters together with Tbp, Taf7l and RNA polymerase II. A set of genes activated in haploid spermatids during the first wave of spermatogenesis is down-regulated by Trf2 inactivation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O95753;Q9Z2Z0", "ec_number_list": "", "go_molecular_function": "GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0016251 RNA polymerase II general transcription initiation factor activity;GO:0140223 general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005672 transcription factor TFIIA complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0001675 acrosome assembly;GO:0007289 spermatid nucleus differentiation;GO:0006352 DNA-templated transcription initiation;GO:0006235 dTTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P62340-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VBL1-1", "uniprot_id": "TIGD2_MOUSE", "mass": 59651.0, "length": 525, "protein_name": "Tigger transposable element-derived protein 2", "gene_name": "Tigd2", "organism": "Mouse", "refseq_name": "tigger transposable element-derived protein 2", "refseq_ac": "NP_001074614", "gene_names_uniprotkb": "Tigd2", "gene_names_refseq": "3632410O17Rik; Tigd2", "protein_names_uniprotkb": "Tigger transposable element-derived protein 2", "protein_names_refseq": "tigger transposable element derived 2 homolog; tigger transposable element-derived protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68140)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q505P7;Q6NV77", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VBL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U0X8-1", "uniprot_id": "TACT_MOUSE", "mass": 67133.0, "length": 602, "protein_name": "T-cell surface protein tactile", "gene_name": "Cd96", "organism": "Mouse", "refseq_name": "T-cell surface protein tactile precursor", "refseq_ac": "NP_115854", "gene_names_uniprotkb": "Cd96", "gene_names_refseq": "1700109I12Rik; Cd96; Tactile", "protein_names_uniprotkb": "T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein", "protein_names_refseq": "T cell activation, increased late expression; T-cell surface protein tactile precursor; T-cell surface protein tactile; cell surface antigen CD96; t cell-activated increased late expression protein", "tax_id": 10090, "disease": "C syndrome (Disease Ontology:DOID:0111581)", "pathway": " (mmu:84544); (R-MMU-198933)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17971293;19056733;24658051;25428506;29531070;30084848;32043568;34417435;34428180", "class_list": "", "function": "BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Blockade of CD96 completely restored the expansion and inflammatory properties of CD96(high) Th9 cells, [RefSeq, PubMed]; CD96 functions as a co-stimulatory receptor to enhance CD8(+) T cell activation and effector responses., [RefSeq, PubMed]; CD96-driven adhesion to CD155 may be crucial in developmental processes, [RefSeq, PubMed]; Knock-out mice display hyperinflammatory responses to lipopolysaccharide and resistance to lung carcinogenesis, [RefSeq, PubMed]; May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation (By similarity)., [UniProtKB]; These results suggest a function of the CD96/CD155-adhesion system in T cell biology., [RefSeq, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 15, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMW0;Q8C9U6;Q99M67", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0032689 negative regulation of type II interferon production;GO:0007160 cell-matrix adhesion;GO:0002728 negative regulation of natural killer cell cytokine production", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q3U0X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UYK3-1", "uniprot_id": "TBCD9_MOUSE", "mass": 143024.0, "length": 1264, "protein_name": "TBC1 domain family member 9", "gene_name": "Tbc1d9", "organism": "Mouse", "refseq_name": "TBC1 domain family member 9 isoform 1", "refseq_ac": "NP_001104774", "gene_names_uniprotkb": "Tbc1d9; Kiaa0882", "gene_names_refseq": "4933431N12Rik; Tbc1d9", "protein_names_uniprotkb": "TBC1 domain family member 9", "protein_names_refseq": "TBC1 domain family member 9 isoform 1", "tax_id": 10090, "disease": "nephrotic syndrome type 20 (Disease Ontology:DOID:0070357)", "pathway": " (mmu:71310)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22645316;30084848;34418053;34428180", "class_list": "", "function": "May act as a GTPase-activating protein for Rab family protein(s)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZW8;Q8BIJ5;Q8BVP3;Q9CUB3", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0003008 system process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UYK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QD06-1", "uniprot_id": "TAA8B_MOUSE", "mass": 38006.0, "length": 344, "protein_name": "Trace amine-associated receptor 8b", "gene_name": "Taar8b", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 8b", "refseq_ac": "NP_001010837", "gene_names_uniprotkb": "Taar8b; Gm1149", "gene_names_refseq": "Gm1149; Taar8b; taR-8b", "protein_names_uniprotkb": "Trace amine-associated receptor 8b; TaR-8b; Trace amine receptor 8b; mTaar8b", "protein_names_refseq": "mTaar8b; trace amine-associated receptor 8b", "tax_id": 10090, "disease": "", "pathway": " (mmu:382348); (R-MMU-375280); (R-MMU-418555)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15718104;16878137;23624375;25391046", "class_list": "", "function": "Expression analyses revealed at most marginal Taar8b expression and no gender differences for almost all analyzed tissues. In heart, locked-nucleic-acid -in situ hybridization demonstrated the absence of Taar8b expression. Publication Status: Online-Only, [RefSeq, PubMed]; Olfactory receptor specific for trace amines (By similarity). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (By similarity). Ligand-binding causes a conformation change that triggers signaling via G alpha proteins, possibly G(i)/G(o) G alpha proteins (PubMed:25391046)., [UniProtKB, UniProtKB, PubMed]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RT24", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5QD06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QD08-1", "uniprot_id": "TAA7F_MOUSE", "mass": 40165.0, "length": 358, "protein_name": "Trace amine-associated receptor 7f", "gene_name": "Taar7f", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 7f", "refseq_ac": "NP_001010839", "gene_names_uniprotkb": "Taar7f", "gene_names_refseq": "Taar7f; taR-7f", "protein_names_uniprotkb": "Trace amine-associated receptor 7f; TaR-7f; Trace amine receptor 7f; mTaar7f", "protein_names_refseq": "mTaar7f; trace amine-associated receptor 7f", "tax_id": 10090, "disease": "", "pathway": " (mmu:435207)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15718104;16878137;22545963;23624375;39215004", "class_list": "", "function": "Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f. Publication Status: Online-Only, [RefSeq, PubMed]; Olfactory receptor activated by trace amines, such as N-methylpiperidine and N,N-dimethylcyclohexylamine (PubMed:16878137, PubMed:22545963). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (PubMed:16878137, PubMed:22545963). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (PubMed:16878137)., [UniProtKB, PubMed, PubMed]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RT90", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5QD08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QD09-1", "uniprot_id": "TAA7E_MOUSE", "mass": 40163.0, "length": 358, "protein_name": "Trace amine-associated receptor 7e", "gene_name": "Taar7e", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 7e", "refseq_ac": "NP_001010835", "gene_names_uniprotkb": "Taar7e; Gm697", "gene_names_refseq": "Gm697; Taar7e; taR-7e", "protein_names_uniprotkb": "Trace amine-associated receptor 7e; TaR-7e; Trace amine receptor 7e; mTaar7e", "protein_names_refseq": "mTaar7e; trace amine-associated receptor 7e", "tax_id": 10090, "disease": "", "pathway": " (mmu:276742)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15718104;16878137;22545963;23624375", "class_list": "", "function": "Olfactory receptor specific for N,N-dimethylalkylamines trace amines (PubMed:22545963). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (PubMed:22545963). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (Probable)., [UniProtKB, PubMed]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5QD09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5QD10-1", "uniprot_id": "TAA7D_MOUSE", "mass": 40305.0, "length": 358, "protein_name": "Trace amine-associated receptor 7d", "gene_name": "Taar7d", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 7d", "refseq_ac": "NP_001010838", "gene_names_uniprotkb": "Taar7d", "gene_names_refseq": "Taar7d; taR-7d", "protein_names_uniprotkb": "Trace amine-associated receptor 7d; TaR-7d; Trace amine receptor 7d; mTaar7d", "protein_names_refseq": "mTaar7d; trace amine-associated receptor 7d", "tax_id": 10090, "disease": "", "pathway": " (mmu:435206)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15718104;16878137;23624375;37225986", "class_list": "", "function": "Olfactory receptor specific for trace amines, such as beta-phenylethylamine (beta-PEA) (PubMed:37225986). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (PubMed:37225986). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (PubMed:37225986)., [UniProtKB, PubMed]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5QD10-1", "record_type": "protein" } ]