[ { "uniprot_canonical_ac": "Q9R269-1", "uniprot_id": "PEPL_MOUSE", "mass": 204004.0, "length": 1755, "protein_name": "Periplakin", "gene_name": "Ppl", "organism": "Mouse", "refseq_name": "periplakin", "refseq_ac": "NP_032935", "gene_names_uniprotkb": "Ppl", "gene_names_refseq": "Ppl", "protein_names_uniprotkb": "Periplakin", "protein_names_refseq": "195kDa protein; periplakin", "tax_id": 10090, "disease": "", "pathway": " (mmu:19041); (R-MMU-6809371); (R-MMU-8851680)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12244133;15226441;17242355;19029034;21183079;21750661;22841549;29515024;33300544;34428180;9521878", "class_list": "", "function": "Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling., [UniProtKB, UniProtKB, UniProtKB]; Study in a mouse model of lung fibrosis induced by bleomycin found that Ppl expression was downregulated in the whole lung and in alveolar epithelial cells (AECs) after bleomycin-induced injury. Deletion of Ppl reduced lung fibrosis after bleomycin injury by promoting antiinflammatory cytokine expression and profoundly altering cellular signaling in AECs, including STAT3 activation, and TGF-beta/smad pathway activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70231;Q9CUT1;Q9JLZ7", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0019897 extrinsic component of plasma membrane", "go_biological_process": "GO:0031424 keratinization;GO:0042060 wound healing;GO:0045104 intermediate filament cytoskeleton organization;GO:0002786 regulation of antibacterial peptide production;GO:0009612 response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9R269-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09012-1", "uniprot_id": "PEX5_MOUSE", "mass": 70756.0, "length": 639, "protein_name": "Peroxisomal targeting signal 1 receptor", "gene_name": "Pex5", "organism": "Mouse", "refseq_name": "peroxisomal targeting signal 1 receptor isoform 2", "refseq_ac": "NP_001264259", "gene_names_uniprotkb": "Pex5; Pxr1", "gene_names_refseq": "ESTM1; PTS1-BP; PTS1R; PXR1P; Pex5; Pxr1", "protein_names_uniprotkb": "Peroxisomal targeting signal 1 receptor; PTS1 receptor; PTS1-BP; PTS1R; PXR1P; Peroxin-5; Peroxisomal C-terminal targeting signal import receptor; Peroxisome receptor 1", "protein_names_refseq": "PTS1 receptor; peroxin 5; peroxisomal C-terminal targeting signal import receptor; peroxisomal targeting signal 1 receptor isoform 2; peroxisomal targeting signal 1 receptor; peroxisome biogenesis factor 5; peroxisome receptor 1", "tax_id": 10090, "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); peroxisome biogenesis disorder 2A (Disease Ontology:DOID:0080477); peroxisome biogenesis disorder 2B (Disease Ontology:DOID:0080622); rhizomelic chondrodysplasia punctata type 5 (Disease Ontology:DOID:0110854)", "pathway": " (mmu:19305); (R-MMU-8866654); (R-MMU-9033241); (R-MMU-9664873)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "15732085;17442273;21750661;25428506;30084848;31219806;31599954;33389129;34418053;34428180;34678516;9288097", "class_list": "", "function": "Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal., [UniProtKB, UniProtKB]; In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UM58;Q8K2V5;Q91YC7", "ec_number_list": "", "go_molecular_function": "GO:0033328 peroxisome membrane targeting sequence binding;GO:0019899 enzyme binding;GO:0031267 small GTPase binding;GO:0005052 peroxisome matrix targeting signal-1 binding;GO:0000268 peroxisome targeting sequence binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0016561 protein import into peroxisome matrix, translocation;GO:0044721 protein import into peroxisome matrix, substrate release;GO:0043335 protein unfolding;GO:0000038 very long-chain fatty acid metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O09012-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55022-1", "uniprot_id": "PGRC1_MOUSE", "mass": 21694.0, "length": 195, "protein_name": "Membrane-associated progesterone receptor component 1", "gene_name": "Pgrmc1", "organism": "Mouse", "refseq_name": "membrane-associated progesterone receptor component 1", "refseq_ac": "NP_058063", "gene_names_uniprotkb": "Pgrmc1; Pgrmc", "gene_names_refseq": "HPR6.6; PPMR; Pgrmc1; Vema; mPR", "protein_names_uniprotkb": "Membrane-associated progesterone receptor component 1; mPR", "protein_names_refseq": "membrane-associated progesterone receptor component 1", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:53328); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "15378723;17208939;17242355;18630941;19131326;19144319;21183079;22645316;25605945;27599036;28005395;30084848;30779550;31748741;34428180;34585989;34645803;34678314;37070746;37453647;37828378", "class_list": "", "function": "Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (PubMed:28005395). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Hepatic progesterone receptor membrane component 1 attenuates ethanol-induced liver injury by reducing acetaldehyde production and oxidative stress., [RefSeq, PubMed]; PGRMC1 Exerts Its Function of Anti-Influenza Virus in the Central Nervous System., [RefSeq, PubMed]; PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones. Publication Status: Online-Only, [RefSeq, PubMed]; Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JN0", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0005496 steroid binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:1905809 negative regulation of synapse organization;GO:0007613 memory;GO:0008306 associative learning;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "O55022-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70400-1", "uniprot_id": "PDLI1_MOUSE", "mass": 35774.0, "length": 327, "protein_name": "PDZ and LIM domain protein 1", "gene_name": "Pdlim1", "organism": "Mouse", "refseq_name": "PDZ and LIM domain protein 1", "refseq_ac": "NP_058557", "gene_names_uniprotkb": "Pdlim1; Clim1", "gene_names_refseq": "CLP36; Clim1; Pdlim1; mClim1", "protein_names_uniprotkb": "PDZ and LIM domain protein 1; C-terminal LIM domain protein 1; Elfin; LIM domain protein CLP-36", "protein_names_refseq": "C-terminal LIM domain protein 1; LIM domain protein CLP-36; PDZ and LIM domain protein 1; carboxyl terminal LIM domain protein 1; elfin", "tax_id": 10090, "disease": "", "pathway": " (mmu:54132)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;11596114;17991461;21183079;21750661;25428506;26495903;28011936;30016717;30059200;30084848;32782141;34428180;35822049;35984892;36288343;36852467;37037887;37212284;37507081;39927985;40021952;40885482", "class_list": "", "function": "Clim1 protein plays an important role in the homeostasis of corneal epithelium and hair follicles., [RefSeq, PubMed]; Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (By similarity). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Direct Knockdown of PDZ and LIM Domain 1 Using an Adenoviral Delivery System Accelerates Osteogenesis and Fracture Healing in Mice., [RefSeq, PubMed]; PDLIM1 inhibits cell migration and invasion in diabetic retinopathy via negatively regulating Wnt3a. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q99K93", "ec_number_list": "", "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003713 transcription coactivator activity;GO:0003779 actin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0001666 response to hypoxia;GO:0030036 actin cytoskeleton organization;GO:0030950 establishment or maintenance of actin cytoskeleton polarity", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "O70400-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10820-1", "uniprot_id": "PERF_MOUSE", "mass": 62081.0, "length": 554, "protein_name": "Perforin-1", "gene_name": "Prf1", "organism": "Mouse", "refseq_name": "perforin-1 precursor", "refseq_ac": "NP_035203", "gene_names_uniprotkb": "Prf1; Pfp", "gene_names_refseq": "Pfn; Pfp; Prf-1; Prf1", "protein_names_uniprotkb": "Perforin-1; Cytolysin; Lymphocyte pore-forming protein; P1", "protein_names_refseq": "P1; cytolysin; lymphocyte pore-forming protein; perforin-1 precursor; perforin-1; pore forming protein", "tax_id": 10090, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); familial hemophagocytic lymphohistiocytosis 2 (Disease Ontology:DOID:0110922); aplastic anemia (Disease Ontology:DOID:12449); Fanconi anemia (Disease Ontology:DOID:13636); colon carcinoma (Disease Ontology:DOID:1520); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); non-Langerhans-cell histiocytosis (Disease Ontology:DOID:4330); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); chronic fatigue syndrome (Disease Ontology:DOID:8544); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:18646)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "1401900;19446473;2040805;21037563;2303785;26306037;2783478;2783486;2783549;3190678;3261391;35148176;35705808;7520535;7526382;7972104;8164737", "class_list": "", "function": "Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells (PubMed:19446473, PubMed:21037563, PubMed:26306037, PubMed:2783478, PubMed:3261391, PubMed:35148176, PubMed:35705808, PubMed:7520535, PubMed:7526382, PubMed:7972104, PubMed:8164737). Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores (PubMed:19446473, PubMed:21037563, PubMed:26306037, PubMed:3261391, PubMed:35148176, PubMed:35705808, PubMed:7526382, PubMed:8164737). Promotes cytolysis and apoptosis of target cells by mediating the passage and uptake of cytotoxic granzymes (PubMed:19446473, PubMed:21037563, PubMed:26306037, PubMed:3261391, PubMed:35148176, PubMed:7526382, PubMed:8164737). Facilitates the delivery of cationic cargo protein, while anionic or neural proteins are not delivered efficiently (By similarity). Perforin pores allow the release of mature caspase-7 (CASP7) into the extracellular milieu (PubMed:35705808)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0022829 wide pore channel activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031904 endosome lumen", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0051712 positive regulation of killing of cells of another organism;GO:0002418 immune response to tumor cell;GO:0046513 ceramide biosynthetic process;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P10820-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32240-1", "uniprot_id": "PE2R4_MOUSE", "mass": 56158.0, "length": 513, "protein_name": "Prostaglandin E2 receptor EP4 subtype", "gene_name": "Ptger4", "organism": "Mouse", "refseq_name": "prostaglandin E2 receptor EP4 subtype isoform 2", "refseq_ac": "NP_032991", "gene_names_uniprotkb": "Ptger4; Ptgerep4", "gene_names_refseq": "EP4; Ptger4; Ptgerep4", "protein_names_uniprotkb": "Prostaglandin E2 receptor EP4 subtype; PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; Prostanoid EP4 receptor", "protein_names_refseq": "PGE2 receptor EP4 subtype; prostaglandin E2 receptor EP4 subtype isoform 2; prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor", "tax_id": 10090, "disease": "aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); osteoporosis (Disease Ontology:DOID:11476); retinal ischemia (Disease Ontology:DOID:12510); dilated cardiomyopathy (Disease Ontology:DOID:12930); cystitis (Disease Ontology:DOID:1679); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); acute kidney failure (Disease Ontology:DOID:3021); aortic aneurysm (Disease Ontology:DOID:3627); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (mmu:19219); (R-MMU-391908); (R-MMU-418555)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "18270204;27802388;8385118;8939885", "class_list": "", "function": "Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004957 prostaglandin E receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0043025 neuronal cell body;GO:0044306 neuron projection terminus", "go_biological_process": "GO:0033624 negative regulation of integrin activation;GO:2000386 positive regulation of ovarian follicle development;GO:0042466 chemokinesis;GO:1904336 negative regulation of ductus arteriosus closure;GO:1904364 positive regulation of calcitonin secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P32240-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43117-1", "uniprot_id": "PF2R_MOUSE", "mass": 40700.0, "length": 366, "protein_name": "Prostaglandin F2-alpha receptor", "gene_name": "Ptgfr", "organism": "Mouse", "refseq_name": "prostaglandin F2-alpha receptor", "refseq_ac": "NP_032992", "gene_names_uniprotkb": "Ptgfr", "gene_names_refseq": "PGF; Ptgfr; fp", "protein_names_uniprotkb": "Prostaglandin F2-alpha receptor; PGF receptor; PGF2-alpha receptor; Prostanoid FP receptor", "protein_names_refseq": "PGF receptor; PGF2-alpha receptor; prostaglandin F2-alpha receptor; prostaglandin F2alpha receptor; prostanoid FP receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:19220); (R-MMU-391908); (R-MMU-416476)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "38682210;8288601", "class_list": "", "function": "Female Type 1 Diabetic Akita Mice Demonstrate Increased Bladder Contractility via FP Receptor Activation due to NLRP3-Mediated Inflammation., [RefSeq, PubMed]; Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004958 prostaglandin F receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P43117-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46718-1", "uniprot_id": "PDCD2_MOUSE", "mass": 38326.0, "length": 343, "protein_name": "uS5 assembly chaperone PDCD2", "gene_name": "Pdcd2", "organism": "Mouse", "refseq_name": "uS5 assembly chaperone PDCD2 isoform 1", "refseq_ac": "NP_032825", "gene_names_uniprotkb": "Pdcd2; Rp8", "gene_names_refseq": "Pcd2; Pdcd2; RP-8", "protein_names_uniprotkb": "uS5 assembly chaperone PDCD2; Programmed cell death protein 2; Zinc finger protein Rp-8", "protein_names_refseq": "programmed cell death protein 2; uS5 assembly chaperone PDCD2 isoform 1; uS5 assembly chaperone PDCD2; zinc finger protein Rp-8", "tax_id": 10090, "disease": "", "pathway": " (mmu:18567)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17468402;7880439", "class_list": "", "function": "Chaperone for ribosomal protein uS5; cotranslationally associates with uS5 and accompanies the ribosomal protein to assembly sites in the nucleus; appears to function redundantly to PDCD2L., [UniProtKB, UniProtKB]; Repression of PDCD2 by BCL6 is likely important in the pathogenesis of certain human lymphomas, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J0N5;Q8BR06", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:1901532 regulation of hematopoietic progenitor cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:1902035 positive regulation of hematopoietic stem cell proliferation;GO:0012501 programmed cell death;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P46718-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49290-1", "uniprot_id": "PERE_MOUSE", "mass": 81380.0, "length": 716, "protein_name": "Eosinophil peroxidase", "gene_name": "Epx", "organism": "Mouse", "refseq_name": "eosinophil peroxidase isoform 1 precursor", "refseq_ac": "NP_031972", "gene_names_uniprotkb": "Epx; Eper", "gene_names_refseq": "EPO; Epx", "protein_names_uniprotkb": "Eosinophil peroxidase; 1.11.1.7; mEPO", "protein_names_refseq": "eosinophil peroxidase isoform 1 precursor", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:13861); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11466391;18250455;18694936;28011936;30084848;33725478;34203471;39627609;8773591", "class_list": "", "function": "Heme-containing oxidoreductase that catalyzes the oxidation of small anions, such as nitrite, halides (e.g bromide and chloride (at pH 6.5)) and pseudohalides (e.g thiocyanate) by using hydrogen peroxide to generate the corresponding reactive species hypobromite, hypochlorite, hypothiocyanous acid, and nitrogen dioxide. Also oxidizes thiocyanate (SCN(-)) to cyanate (OCN(-)). Functionally involved in inflammatory responses and exhibits antimicrobial activity (By similarity). Can also oxidize amino acid residues on proteins and generate bromination, nitration and carbamoylation post-translational modifications, respectively (PubMed:18694936). Mediates the nitration of tyrosine (3-nitrotyrosine) which is only observed in secondary granule proteins in mature resting eosinophils in the presence of the cosubstrates, hydrogen peroxide and nitrite (PubMed:18694936). Mediates oxidation of tyrosine residues on proteins in eosinophils to form brominating species, 3-bromotyrosine and 3, 5-dibromotyrosine in the presence of hydrogen peroxide and bromide (By similarity). Promotes protein carbamoylation at sites of inflammation during asthma by using thiocyanate and hydrogen peroxide to form cyanate which carbamoylates lysine residues to form homocitrulline (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; The activities of EPO, an eosinophilic secondary granule protein, do not affect the development of allergic pulmonary pathologies in the mouse lung at levels comparable to those observed in humans with asthma., [RefSeq, PubMed]; This gene encodes a member of the peroxidase superfamily of enzymes that is produced by eosinophils and plays a critical role in eliminating tissue-invasive parasites. The encoded preproprotein undergoes proteolytic processing to generate a heterodimeric enzyme that forms a predominant component of the intracellular granules of eosinophils. Mice lacking the encoded protein exhibit resistance to ulcerative colitis induced by dextran sulfate. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q5SW51;Q61798", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.19.12;1.1.1.42;3.4.21.46;1.11.1.-;1.7.-.-;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;2.4.2.7;3.6.5.-;4.2.1.24;1.11.2.2;2.7.1.11;2.7.10.2;5.2.1.8;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;1.11.1.6;1.1.1.205;5.3.2.1;5.3.3.12;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;1.11.1.7;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.11.39;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;1.11.2.-;3.1.1.47;3.6.4.13;2.3.2.26;5.4.2.2;5.4.2.7;2.7.1.35;4.1.2.4;1.15.1.1;1.14.12.-;5.4.2.11;5.4.2.4;2.4.1.1;2.4.1.186", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004601 peroxidase activity;GO:0140825 lactoperoxidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032693 negative regulation of interleukin-10 production;GO:0032714 negative regulation of interleukin-5 production;GO:0006979 response to oxidative stress;GO:0042742 defense response to bacterium;GO:0042744 hydrogen peroxide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P49290-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58196-1", "uniprot_id": "PLS4_MOUSE", "mass": 36579.0, "length": 326, "protein_name": "Phospholipid scramblase 4", "gene_name": "Plscr4", "organism": "Mouse", "refseq_name": "phospholipid scramblase 4 isoform 1", "refseq_ac": "NP_848826", "gene_names_uniprotkb": "Plscr4", "gene_names_refseq": "Plscr4", "protein_names_uniprotkb": "Phospholipid scramblase 4; Ca(2+)-dependent phospholipid scramblase 4; PL scramblase 4", "protein_names_refseq": "PL scramblase 4; ca(2+)-dependent phospholipid scramblase 4; phospholipid scramblase 4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:235527)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20484733;22598484;25428506;30084848;30779550;34428180;36210013", "class_list": "", "function": "Catalyzes metal ion-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane and participates in the redistribution of phospholipids between membrane leaflets. Metal ions bind to the calcium-binding site and induce conformation change in the protein. Has a greater affi nity for Ca(2+) than Mg(2+) and Zn(2+)., [UniProtKB, UniProtKB]; Lipopolysaccharide treatment resulted in increased expression of phospholipid scramblase 1(PLSCR-1) and decrease in phospholipid scramblase 4(Plscr4 )messenger RNA demonstrating modulation of PLSCR-1 and PLSCR-4 in lipopolysaccharide-induced preterm birth, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMI2;Q8BH62", "ec_number_list": "1.6.5.5;3.1.-.-", "go_molecular_function": "GO:0019899 enzyme binding;GO:0042609 CD4 receptor binding;GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane", "go_biological_process": "GO:0071222 cellular response to lipopolysaccharide;GO:0017121 plasma membrane phospholipid scrambling;GO:0061589 calcium activated phosphatidylserine scrambling;GO:0061590 calcium activated phosphatidylcholine scrambling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P58196-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59114-1", "uniprot_id": "CAPAM_MOUSE", "mass": 80504.0, "length": 706, "protein_name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase", "gene_name": "Pcif1", "organism": "Mouse", "refseq_name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase isoform 2", "refseq_ac": "NP_666241", "gene_names_uniprotkb": "Pcif1", "gene_names_refseq": "2310022K11Rik; C20orf67; CAPAM; F730014I05Rik; Pcif1", "protein_names_uniprotkb": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; 2.1.1.62; CAPAM; Cap-specific adenosine methyltransferase; Phosphorylated CTD-interacting factor 1", "protein_names_refseq": "PDX1 C-terminal inhibiting factor 1; cap-specific adenosine methyltransferase; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase isoform 2; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; phosphorylated CTD interacting factor PCIF1", "tax_id": 10090, "disease": "", "pathway": " (mmu:228866)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17242355;21183079;25428506;30084848;30487554;32814042;34428180;36514940;39290151;40885482", "class_list": "", "function": "Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30487554). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (By similarity)., [UniProtKB, UniProtKB, PubMed]; M[6]Am Methyltransferase PCIF1 Regulates Periodontal Inflammation., [RefSeq, PubMed]; Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy., [RefSeq, PubMed]; The Mammalian Cap-Specific m(6)Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.62", "go_molecular_function": "GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding;GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding;GO:0099122 RNA polymerase II C-terminal domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge", "go_biological_process": "GO:0006397 mRNA processing;GO:0017148 negative regulation of translation;GO:0045727 positive regulation of translation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P59114-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61759-1", "uniprot_id": "PFD3_MOUSE", "mass": 22436.0, "length": 196, "protein_name": "Prefoldin subunit 3", "gene_name": "Vbp1", "organism": "Mouse", "refseq_name": "prefoldin subunit 3", "refseq_ac": "NP_035822", "gene_names_uniprotkb": "Vbp1; Pfdn3", "gene_names_refseq": "VBP-1; Vbp1", "protein_names_uniprotkb": "Prefoldin subunit 3; VBP-1; VHL-binding protein 1; von Hippel-Lindau-binding protein 1", "protein_names_refseq": "VHL-binding protein 1; prefoldin subunit 3", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:22327)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25153642;28135057;28528544;30084848;9339366", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55228;Q15765;Q3U6M9;Q9CPZ0", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0001540 amyloid-beta binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016272 prefoldin complex", "go_biological_process": "GO:0006457 protein folding;GO:0007021 tubulin complex assembly;GO:1905907 negative regulation of amyloid fibril formation;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P61759-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63054-1", "uniprot_id": "PCP4_MOUSE", "mass": 6807.0, "length": 62, "protein_name": "Calmodulin regulator protein PCP4", "gene_name": "Pcp4", "organism": "Mouse", "refseq_name": "calmodulin regulator protein PCP4", "refseq_ac": "NP_032817", "gene_names_uniprotkb": "Pcp4; Pep19", "gene_names_refseq": "P16Rimb19; Pcp-4; Pcp4; Pep19", "protein_names_uniprotkb": "Calmodulin regulator protein PCP4; Brain-specific antigen PCP-4; Brain-specific polypeptide PEP-19; Purkinje cell protein 4", "protein_names_refseq": "brain-specific antigen PCP-4; brain-specific polypeptide PEP-19; calmodulin regulator protein PCP4", "tax_id": 10090, "disease": "leiomyoma (Disease Ontology:DOID:127); Huntington's disease (Disease Ontology:DOID:12858); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (mmu:18546)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;2320430;26495903;8361346", "class_list": "", "function": "Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P07734;Q63890", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0005516 calmodulin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0005883 neurofilament;GO:0032991 protein-containing complex", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0045666 positive regulation of neuron differentiation;GO:0006469 negative regulation of protein kinase activity;GO:0043524 negative regulation of neuron apoptotic process;GO:0033603 positive regulation of dopamine secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P63054-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70263-1", "uniprot_id": "PD2R_MOUSE", "mass": 40005.0, "length": 357, "protein_name": "Prostaglandin D2 receptor", "gene_name": "Ptgdr", "organism": "Mouse", "refseq_name": "prostaglandin D2 receptor", "refseq_ac": "NP_032988", "gene_names_uniprotkb": "Ptgdr", "gene_names_refseq": "DP; PGD; Ptgdr", "protein_names_uniprotkb": "Prostaglandin D2 receptor; PGD receptor; PGD2 receptor; Prostanoid DP receptor", "protein_names_refseq": "PGD receptor; PGD2 receptor; prostaglandin D2 receptor; prostanoid DP receptor", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); asthma (Disease Ontology:DOID:2841); pulmonary hypertension (Disease Ontology:DOID:6432); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (mmu:19214); (R-MMU-391908); (R-MMU-418555)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "23624557;7972033", "class_list": "", "function": "Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2RSY4;Q8CCM3", "ec_number_list": "", "go_molecular_function": "GO:0001785 prostaglandin J receptor activity;GO:0004956 prostaglandin D receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0046085 adenosine metabolic process;GO:0030431 sleep;GO:0071799 cellular response to prostaglandin D stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P70263-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97865-1", "uniprot_id": "PEX7_MOUSE", "mass": 35502.0, "length": 318, "protein_name": "Peroxisomal targeting signal 2 receptor", "gene_name": "Pex7", "organism": "Mouse", "refseq_name": "peroxisomal biogenesis factor 7 isoform 1", "refseq_ac": "NP_032848", "gene_names_uniprotkb": "Pex7", "gene_names_refseq": "MmPEX7; Pex7", "protein_names_uniprotkb": "Peroxisomal targeting signal 2 receptor; PTS2 receptor; Peroxin-7", "protein_names_refseq": "PTS2 receptor; peroxin-7; peroxisomal biogenesis factor 7 isoform 1; peroxisomal targeting signal 2 receptor; peroxisome biogenesis factor 7", "tax_id": 10090, "disease": "Peroxisome biogenesis disorder 9B (Disease Ontology:DOID:0081438); rhizomelic chondrodysplasia punctata type 1 (Disease Ontology:DOID:0110851)", "pathway": " (mmu:18634); (R-MMU-9033241)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12915479;25605945;9090381", "class_list": "", "function": "Mutations in the Pex7 gene cause impaired neuronal migration and endochondral ossification., [RefSeq, PubMed]; Receptor required for the peroxisomal import of proteins containing an N-terminal PTS2-type peroxisomal targeting signal (PubMed:12915479, PubMed:9090381). Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol (By similarity). Cargo protein-binding triggers interaction with PEX5 and formation of a ternary complex composed of PEX5 and PEX7 along with PTS2-containing cargo proteins, which is translocated into peroxisomes by passing through the PEX13-PEX14 docking complex (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RSR2", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0005053 peroxisome matrix targeting signal-2 binding", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0008611 ether lipid biosynthetic process;GO:0001764 neuron migration;GO:0007031 peroxisome organization;GO:0006625 protein targeting to peroxisome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97865-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04592-1", "uniprot_id": "PCSK5_MOUSE", "mass": 209257.0, "length": 1877, "protein_name": "Proprotein convertase subtilisin/kexin type 5", "gene_name": "Pcsk5", "organism": "Mouse", "refseq_name": "proprotein convertase subtilisin/kexin type 5 isoform 1 preproprotein", "refseq_ac": "NP_001177412", "gene_names_uniprotkb": "Pcsk5", "gene_names_refseq": "PC5; PC6; Pcsk5; SPC6; b2b1549Clo; b2b585Clo", "protein_names_uniprotkb": "Proprotein convertase subtilisin/kexin type 5; 3.4.21.-; PC5; PC6; Proprotein convertase 5; Proprotein convertase 6; SPC6; Subtilisin-like proprotein convertase 6; Subtilisin/kexin-like protease PC5", "protein_names_refseq": "proprotein convertase 5; proprotein convertase PC5; proprotein convertase subtilisin/kexin type 5 isoform 1 preproprotein; subtilisin-like proprotein convertase 6; subtilisin/kexin-like protease PC5", "tax_id": 10090, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); sciatic neuropathy (Disease Ontology:DOID:11446); VACTERL association (Disease Ontology:DOID:14679); colon adenocarcinoma (Disease Ontology:DOID:234); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:18552); (R-MMU-167060); (R-MMU-8963889)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;25428506;30084848;32942293;34149625;34428180;36210013;8335106;8341687;8468318;8698813;8947550;9291583", "class_list": "", "function": "Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix., [RefSeq, PubMed]; In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23. Publication Status: Online-Only, [RefSeq, PubMed]; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors., [UniProtKB]; This gene encodes a subtilisin-like proprotein convertase that mediates posttranslational endoproteolytic processing of various proprotein substrates traversing the secretory pathway. The encoded protein is an inactive zymogen that undergoes autoproteolytic processing in the endoplasmic reticulum and the Golgi network to generate an active enzyme. Mice lacking the encoded protein die at an early embryonic stage. Conditional inactivation this gene in the epiblast but not in the extraembryonic tissue bypasses embryonic lethality but results in death at birth. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]., [RefSeq]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9536, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "E9QPB7;Q62040", "ec_number_list": "3.1.1.32;3.1.1.34;3.4.21.94;3.4.21.75;3.4.21.-;3.4.21.93", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0004866 endopeptidase inhibitor activity;GO:0042277 peptide binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus;GO:0030141 secretory granule", "go_biological_process": "GO:0019058 viral life cycle;GO:1905609 positive regulation of smooth muscle cell-matrix adhesion;GO:0007507 heart development;GO:0016485 protein processing;GO:0016486 peptide hormone processing", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q04592-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VB07-1", "uniprot_id": "PGRP4_MOUSE", "mass": 41190.0, "length": 374, "protein_name": "Peptidoglycan recognition protein 4", "gene_name": "Pglyrp4", "organism": "Mouse", "refseq_name": "peptidoglycan recognition protein 4 isoform 2 precursor", "refseq_ac": "NP_997146", "gene_names_uniprotkb": "Pglyrp4; Pgrpib", "gene_names_refseq": "Gm1478; Gm413; Pglyrp4", "protein_names_uniprotkb": "Peptidoglycan recognition protein 4; PGLYRPIbeta; PGRP-I-beta; Peptidoglycan recognition protein I-beta; Peptidoglycan recognition protein intermediate beta", "protein_names_refseq": "PGLYRPIbeta; PGRP-I-beta; peptidoglycan recognition protein 4 isoform 2 precursor; peptidoglycan recognition protein I-beta; peptidoglycan recognition protein intermediate beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:384997); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15177568;26332373", "class_list": "", "function": "Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Also binds to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity (By similarity)., [UniProtKB]; Pglyrp-2 expression was induced after infection in WT mice. Pglyrp-3 expression was low before and after infection in WT mice, while Pglyrp-4 expression was slightly elevated after infection in WT, Pglyrp-2 and -3 null mice Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6R1Z1", "ec_number_list": "", "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008745 N-acetylmuramoyl-L-alanine amidase activity;GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0016019 peptidoglycan immune receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0032827 negative regulation of natural killer cell differentiation involved in immune response;GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VB07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3URU2-1", "uniprot_id": "PEG3_MOUSE", "mass": 178932.0, "length": 1571, "protein_name": "Paternally-expressed gene 3 protein", "gene_name": "Peg3", "organism": "Mouse", "refseq_name": "paternally-expressed gene 3 protein isoform a", "refseq_ac": "NP_032843", "gene_names_uniprotkb": "Peg3; Kiaa0287; Pw1", "gene_names_refseq": "ASF-1; End4; Gcap4; Peg3; Pw1; Zfp102; mKIAA0287", "protein_names_uniprotkb": "Paternally-expressed gene 3 protein; ASF-1", "protein_names_refseq": "granule cell antiserum positive 4; paternally expressed gene 3; paternally-expressed gene 3 protein isoform a; paternally-expressed gene 3 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:18616)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10195900;10681424;10704281;11260267;11331620;11943780;21750661;25333865;25428506;30059200;36210013;38605443;8563758;8806818;9500555", "class_list": "", "function": "CircBCL2L13 attenuates cardiomyocyte oxidative stress and apoptosis in cardiac ischemia-reperfusion injury via miR-1246/PEG3 signaling., [RefSeq, PubMed]; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Plays a role in regulating maternal behavior and offspring growth., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; PEG3/Peg3 genes in human and mouse are imprinted, with preferential expression from the paternal allele in placenta., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54978;Q3TQ69;Q5EBP7;Q61138;Q6GQS0;Q80U47;Q8R5N0;Q9QX53", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005776 autophagosome;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3URU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIZ9-1", "uniprot_id": "PLS3_MOUSE", "mass": 31803.0, "length": 296, "protein_name": "Phospholipid scramblase 3", "gene_name": "Plscr3", "organism": "Mouse", "refseq_name": "phospholipid scramblase 3", "refseq_ac": "NP_001161969", "gene_names_uniprotkb": "Plscr3", "gene_names_refseq": "2210403O21Rik; 2610037N06Rik; ESTM3; Plscr3", "protein_names_uniprotkb": "Phospholipid scramblase 3; Ca(2+)-dependent phospholipid scramblase 3; PL scramblase 3", "protein_names_refseq": "Ca 2+ dependent phospholipid scramblase 3; PL scramblase 3; ca(2+)-dependent phospholipid scramblase 3; phospholipid scramblase 3", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:70310)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10930526;15328404;17355638;19428821;21750661;21785166;26677203;37828378", "class_list": "", "function": "Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (By similarity). Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (By similarity). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (Probable). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (By similarity). Regulates cardiolipin de novo biosynthesis and its resynthesis (By similarity)., [UniProtKB, UniProtKB, PubMed]; Expression of PLSCR3 may be required for normal adipocyte and/or macrophage maturation or function, [RefSeq, PubMed]; Identified previously unrecognized lipid metabolites that suggest a novel molecular link between obesity, inflammation and the downstream consequences associated with PLSCR3-deficiency, [RefSeq, PubMed]; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane., [UniProtKB, UniProtKB]; Results suggest that Scr3 functions as a negative regulator of adipogenesis in 3T3-L1 cells at a specific differentiation stage and that decrease in the intracellular amount of Scr3 protein caused by reduction in Scr3 mRNA expression Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.6.5.5;3.1.-.-;2.7.4.6", "go_molecular_function": "GO:0032791 lead ion binding;GO:0000287 magnesium ion binding;GO:0017124 SH3 domain binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0090199 regulation of release of cytochrome c from mitochondria;GO:0006915 apoptotic process;GO:0071222 cellular response to lipopolysaccharide;GO:0042593 glucose homeostasis;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JIZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P1Z5-1", "uniprot_id": "PED1A_MOUSE", "mass": 51311.0, "length": 449, "protein_name": "PC-esterase domain-containing protein 1A", "gene_name": "Pced1a", "organism": "Mouse", "refseq_name": "PC-esterase domain-containing protein 1A", "refseq_ac": "NP_001108013", "gene_names_uniprotkb": "Pced1a; Fam113a", "gene_names_refseq": "A930025D01Rik; Fam113a; Pced1a", "protein_names_uniprotkb": "PC-esterase domain-containing protein 1A; Protein FAM113A", "protein_names_refseq": "PC-esterase domain-containing protein 1A; family with sequence similarity 113, member A; protein FAM113A", "tax_id": 10090, "disease": "", "pathway": " (mmu:319513)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BI89", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P1Z5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PB75-1", "uniprot_id": "PAPD7_MOUSE", "mass": 84326.0, "length": 785, "protein_name": "Terminal nucleotidyltransferase 4A", "gene_name": "Tent4a", "organism": "Mouse", "refseq_name": "terminal nucleotidyltransferase 4A isoform 1", "refseq_ac": "NP_941002", "gene_names_uniprotkb": "Tent4a; Papd7; Pols", "gene_names_refseq": "LAK-1; POLK; Papd7; Pols; TRF4-1; TRF4; Tent4a", "protein_names_uniprotkb": "Terminal nucleotidyltransferase 4A; 2.7.7.-; 2.7.7.19; DNA polymerase sigma; Non-canonical poly(A) RNA polymerase PAPD7; PAP-associated domain-containing protein 7; TRAMP-like complex polyadenylate polymerase; Terminal guanylyltransferase", "protein_names_refseq": "DNA polymerase sigma; PAP associated domain containing 7; PAP-associated domain-containing protein 7; TRAMP-like complex polyadenylate polymerase; non-canonical poly(A) RNA polymerase PAPD7; polymerase (DNA directed) sigma; terminal guanylyltransferase; terminal nucleotidyltransferase 4A isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:210106)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (By similarity). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JDV2;G3X948", "ec_number_list": "2.7.7.19;2.7.7.52;2.7.7.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:1990817 poly(A) RNA polymerase activity;GO:0070568 guanylyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005794 Golgi apparatus;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006397 mRNA processing;GO:0009410 response to xenobiotic stimulus;GO:0031123 RNA 3'-end processing;GO:1905870 positive regulation of 3'-UTR-mediated mRNA stabilization;GO:0060212 negative regulation of nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PB75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PB90-1", "uniprot_id": "PCDBE_MOUSE", "mass": 87022.0, "length": 796, "protein_name": "Protocadherin beta-14", "gene_name": "Pcdhb14", "organism": "Mouse", "refseq_name": "protocadherin beta-14 precursor", "refseq_ac": "NP_444369", "gene_names_uniprotkb": "Pcdhb14", "gene_names_refseq": "2210006M07Rik; Pcdhb14; PcdhbN", "protein_names_uniprotkb": "Protocadherin beta-14; PCDH-beta-14", "protein_names_refseq": "PCDH-beta-14; Protocadherin-betaN; cell-cell adhesion molecule; protocadherin beta-14 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:93885)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11230163;15240697;34428180", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCT0;Q91Y05", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6PB90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZPK0-10", "uniprot_id": "PF21A_MOUSE", "mass": 75597.0, "length": 688, "protein_name": "PHD finger protein 21A", "gene_name": "Phf21a", "organism": "Mouse", "refseq_name": "PHD finger protein 21A isoform 3", "refseq_ac": "NP_001103161", "gene_names_uniprotkb": "Phf21a; Bhc80; Kiaa1696; Pftf1", "gene_names_refseq": "80kDa; BHC80a; Bhc80; Bhc; D030065N23Rik; PFTF1; Phf21a; mBHC80", "protein_names_uniprotkb": "PHD finger protein 21A; BHC80a; BRAF35-HDAC complex protein BHC80; mBHC80", "protein_names_refseq": "BRAF35-HDAC complex protein BHC80; BRAF35/HDAC2 complex; Braf35/HDAC complex (Bhc); PHD finger protein 21A isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:192285); (R-MMU-3214815); (R-MMU-983231)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "15325272;16684532;21606357;22645316;23443134;26192747;32782141;32848054;34428180;36852467;40021952;40885482", "class_list": "", "function": "Bhc80 is indispensable for the survival of neonatal pups., [RefSeq, PubMed]; Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation (By similarity)., [UniProtKB]; Presumably serves as a scaffold protein in BHC in neuronal as well as non-neuronal cells. Possible role in spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A2AHG2;Q6XVG0;Q80Z33;Q8CAZ4;Q8VEC8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000118 histone deacetylase complex;GO:1990391 DNA repair complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001967 suckling behavior;GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q6ZPK0-10", "record_type": "protein" }, { "uniprot_canonical_ac": "Q78Y63-1", "uniprot_id": "PDCL2_MOUSE", "mass": 27770.0, "length": 240, "protein_name": "Phosducin-like protein 2", "gene_name": "Pdcl2", "organism": "Mouse", "refseq_name": "phosducin-like protein 2 isoform 2", "refseq_ac": "NP_001297566", "gene_names_uniprotkb": "Pdcl2", "gene_names_refseq": "1700010B22Rik; 1700016K07Rik; Mgcphlp; Pdcl2; Tphlp", "protein_names_uniprotkb": "Phosducin-like protein 2; MgcPhLP; Phosducin-like protein similar 1", "protein_names_refseq": "phosducin-like protein 2 isoform 2; phosducin-like protein 2; phosducin-like protein similar 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:79455)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11116088;12424248;25428506;31519761;36253364;36278277", "class_list": "", "function": "Essential for male fertility, spermiogenesis and acrosome formation., [UniProtKB, PubMed, PubMed]; PDCL2 is essential for sperm acrosome formation and male fertility in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0H7;Q9DA99;Q9WUP3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0006457 protein folding;GO:0001675 acrosome assembly;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q78Y63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UU9-1", "uniprot_id": "PGRC2_MOUSE", "mass": 23334.0, "length": 217, "protein_name": "Membrane-associated progesterone receptor component 2", "gene_name": "Pgrmc2", "organism": "Mouse", "refseq_name": "membrane-associated progesterone receptor component 2", "refseq_ac": "NP_081834", "gene_names_uniprotkb": "Pgrmc2", "gene_names_refseq": "4631434O19Rik; 5730409G06Rik; DG6; PMBP; Pgrmc2", "protein_names_uniprotkb": "Membrane-associated progesterone receptor component 2", "protein_names_refseq": "membrane-associated progesterone receptor component 2; progesterone membrane binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:70804); (R-MMU-8980692); (R-MMU-9013404); (R-MMU-9013408); (R-MMU-9013423); (R-MMU-9707616)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "17242355;18630941;19131326;19144319;21183079;28005395;28135057;28528544;30306772;31748741;34428180;36794556", "class_list": "", "function": "Ensuing alterations in gene expression caused severe mitochondrial defects that rendered adipose-specific PGRMC2-null mice unable to activate adaptive thermogenesis and prone to greater metabolic deterioration when fed a high-fat diet, [RefSeq, PubMed]; Gain-of-function of progesterone receptor membrane component 2 ameliorates ischemic brain injury., [RefSeq, PubMed]; Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (PubMed:28005395). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (PubMed:31748741)., [UniProtKB, PubMed, PubMed]; Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan., [RefSeq, PubMed]; Survival of adult primordial ovarian follicles dependent in part on progesterone receptor membrane component 1 and 2 Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015232 heme transmembrane transporter activity;GO:0005496 steroid binding;GO:0020037 heme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0060612 adipose tissue development;GO:0015886 heme transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q80UU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHW2-1", "uniprot_id": "OSCP1_MOUSE", "mass": 43232.0, "length": 379, "protein_name": "Protein OSCP1", "gene_name": "Oscp1", "organism": "Mouse", "refseq_name": "protein OSCP1 isoform 1", "refseq_ac": "NP_766289", "gene_names_uniprotkb": "Oscp1", "gene_names_refseq": "1810007P19Rik; 5730415O04; 6030436A01Rik; Oscp1", "protein_names_uniprotkb": "Protein OSCP1", "protein_names_refseq": "organic solute carrier 1; organic solute carrier protein 1; protein OSCP1 isoform 1; protein OSCP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:230751)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16006562;17446263;18324622;20173027;21331566;29227538", "class_list": "", "function": "Abberant expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma, [RefSeq, PubMed]; May be involved in drug clearance in the placenta., [UniProtKB]; Mouse testis OSCP1 may indirectly mediate substrate uptake into meiotic and spermiogenic germ cells, within the cytosol., [RefSeq, PubMed]; Report molecular cloning/functional characterization of Oscp1 from mouse testes., [RefSeq, PubMed]; The results indicate that OSCP1 may have a role in the brain indirectly mediating substrate uptake into the neurons in adult animals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHQ7", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BHW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIZ0-1", "uniprot_id": "PCD20_MOUSE", "mass": 104737.0, "length": 952, "protein_name": "Protocadherin-20", "gene_name": "Pcdh20", "organism": "Mouse", "refseq_name": "protocadherin-20 precursor", "refseq_ac": "NP_848800", "gene_names_uniprotkb": "Pcdh20", "gene_names_refseq": "C630015B17Rik; Pcdh13; Pcdh20", "protein_names_uniprotkb": "Protocadherin-20", "protein_names_refseq": "protocadherin 13; protocadherin-20 precursor", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:219257)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;18095321;35820727", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein., [UniProtKB]; The gender difference in PCDH20 expression may reflect olfactory receptor expression differences for gender-specific social discrimination, [RefSeq, PubMed]; This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in cell adhesion in the nervous system and has been shown to be specifically expressed in newly differentiated olfactory sensory neurons and their axons during development. In adult mice, the expression of this protein in the olfactory system is more restricted but shows a gender difference with higher expression in the male than in the female. [provided by RefSeq, Sep 2009]., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "E9QK76;Q8BIV2", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BIZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQN6-1", "uniprot_id": "OZF_MOUSE", "mass": 33093.0, "length": 292, "protein_name": "Zinc finger protein OZF", "gene_name": "Znf146", "organism": "Mouse", "refseq_name": "zinc finger protein OZF", "refseq_ac": "NP_036110", "gene_names_uniprotkb": "Znf146; Ozf; Zfp146", "gene_names_refseq": "OZF; Zfp146; Znf146", "protein_names_uniprotkb": "Zinc finger protein OZF; Only zinc finger protein; Zinc finger protein 146", "protein_names_refseq": "only zinc finger protein; zinc finger protein OZF", "tax_id": 10090, "disease": "", "pathway": " (mmu:26465)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10449921;12437081", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JNX3;Q9Z0Q5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BQN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BX10-1", "uniprot_id": "PGAM5_MOUSE", "mass": 31994.0, "length": 288, "protein_name": "Serine/threonine-protein phosphatase PGAM5, mitochondrial", "gene_name": "Pgam5", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1", "refseq_ac": "NP_001157010", "gene_names_uniprotkb": "Pgam5", "gene_names_refseq": "2610528A17Rik; Pgam5", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PGAM5, mitochondrial; 3.1.3.16; Phosphoglycerate mutase family member 5", "protein_names_refseq": "serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1; serine/threonine-protein phosphatase PGAM5, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:72542); (R-MMU-8934903); (R-MMU-9861718)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "21750661;22265414;25012655;25222142;32439975;34428180;38433252;38464835;38609411;39183280", "class_list": "", "function": "Data indicate that phosphoglycerate mutase 5 (PGAM5) contains an N-terminal WDXNWD motif required for multimerization and maximal phosphatase activity., [RefSeq, PubMed]; Experimental data indicate that the two splice variants of the mitochondrial protein phosphatase PGAM5 are at the convergent point of multiple necrosis pathways., [RefSeq, PubMed]; Loss of PGAM5 disables PINK1-mediated mitophagy in vitro and leads to dopaminergic neurodegeneration and mild dopamine loss in vivo causing a Parkinson's-like movement disorder. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy. Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1. Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation. Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3. Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 (By similarity). Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria (PubMed:22265414)., [UniProtKB, UniProtKB, PubMed]; Phosphoglycerate mutase 5 aggravates alcoholic liver disease through disrupting VDAC-1-dependent mitochondrial integrity. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphoglycerate mutase 5 exacerbates liver ischemia-reperfusion injury by activating mitochondrial fission. Publication Status: Online-Only, [RefSeq, PubMed]; SIRT6 prevent chronic cerebral hypoperfusion induced cognitive impairment by remodeling mitochondrial dynamics in a STAT5-PGAM5-Drp1 dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSM6;Q3UK19;Q80VY8;Q8BM78;Q9CZU2", "ec_number_list": "3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;1.1.1.40;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0090141 positive regulation of mitochondrial fission;GO:0070266 necroptotic process;GO:0120163 negative regulation of cold-induced thermogenesis;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BX10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2W9-1", "uniprot_id": "PANK3_MOUSE", "mass": 41120.0, "length": 370, "protein_name": "Pantothenate kinase 3", "gene_name": "Pank3", "organism": "Mouse", "refseq_name": "pantothenate kinase 3", "refseq_ac": "NP_666074", "gene_names_uniprotkb": "Pank3", "gene_names_refseq": "Pank3", "protein_names_uniprotkb": "Pantothenate kinase 3; 2.7.1.33; Pantothenic acid kinase 3; mPanK3", "protein_names_refseq": "mPanK3; pantothenate kinase 3; pantothenic acid kinase 3", "tax_id": 10090, "disease": "pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981)", "pathway": " (mmu:211347); (R-MMU-196783)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16040613;17379144;22872234;23152917;31219806;34428180", "class_list": "", "function": "Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis., [UniProtKB, PubMed, PubMed]; Murine pantothenate kinase 3 is regulated through a feedback mechanism by coenzyme A and coenzyme A thioesters, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.33", "go_molecular_function": "GO:0019842 vitamin binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0004594 pantothenate kinase activity;GO:1905502 acetyl-CoA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016310 phosphorylation;GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R2W9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4W6-1", "uniprot_id": "PCOC2_MOUSE", "mass": 45408.0, "length": 414, "protein_name": "Procollagen C-endopeptidase enhancer 2", "gene_name": "Pcolce2", "organism": "Mouse", "refseq_name": "procollagen C-endopeptidase enhancer 2 precursor", "refseq_ac": "NP_083896", "gene_names_uniprotkb": "Pcolce2; Pcpe2", "gene_names_refseq": "2400001O18Rik; Pcolce2; Pcpe2", "protein_names_uniprotkb": "Procollagen C-endopeptidase enhancer 2; PCPE-2; Procollagen C-proteinase enhancer 2; Procollagen COOH-terminal proteinase enhancer 2", "protein_names_refseq": "PCPE-2; procollagen C-endopeptidase enhancer 2 precursor; procollagen C-proteinase enhancer 2; procollagen COOH-terminal proteinase enhancer 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:76477); (R-MMU-1650814)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12063410;12393877;22610170;25428506;25947382;28011936;34551590", "class_list": "", "function": "Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9., [RefSeq, PubMed]; Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1., [UniProtKB]; It was shown that PCOLCE2 is required for efficient procollagen processing and deposition of fibrillar collagen in the pressure-overloaded myocardium., [RefSeq, PubMed]; PCPE2 is shown to be a glycoprotein that differs markedly in the nature of its glycosylation from that of PCPE1, [RefSeq, PubMed]; PCPE2 was shown to enhance SR-BI function by increasing the rate of HDL-associated cholesteryl ester uptake, possibly by optimizing SR-BI localization and/or conformation., [RefSeq, PubMed]; Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1K6;Q9CX06", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0016504 peptidase activator activity;GO:0005518 collagen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R4W6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCC1-1", "uniprot_id": "PGDH_MOUSE", "mass": 29181.0, "length": 269, "protein_name": "15-hydroxyprostaglandin dehydrogenase [NAD(+)]", "gene_name": "Hpgd", "organism": "Mouse", "refseq_name": "15-hydroxyprostaglandin dehydrogenase [NAD(+)]", "refseq_ac": "NP_032304", "gene_names_uniprotkb": "Hpgd; Pgdh1", "gene_names_refseq": "15-PGDH; Hpgd", "protein_names_uniprotkb": "15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 1.1.1.-; 1.1.1.141; 1.1.1.232; 15-PGDH; Eicosanoid/docosanoid dehydrogenase [NAD(+)]; Prostaglandin dehydrogenase 1", "protein_names_refseq": "15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 15-hydroxyprostaglandin dehydrogenase; PGDH; eicosanoid/docosanoid dehydrogenase; prostaglandin dehydrogenase 1", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); primary hypertrophic osteoarthropathy (Disease Ontology:DOID:14283); colon carcinoma (Disease Ontology:DOID:1520); carcinoma (Disease Ontology:DOID:305); prolactinoma (Disease Ontology:DOID:5394); growth hormone secreting pituitary adenoma (Disease Ontology:DOID:6255); pulmonary hypertension (Disease Ontology:DOID:6432); peptic ulcer disease (Disease Ontology:DOID:750)", "pathway": " (mmu:15446); (R-MMU-2142700); (R-MMU-9018676); (R-MMU-9018896)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "20448048;30084848;30779550;34428180;36045676;37140231;37934242;8950170", "class_list": "", "function": "Bile exosomal miR-182/183-5p increases cholangiocarcinoma stemness and progression by targeting HPGD and increasing PGE2 generation., [RefSeq, PubMed]; Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (By similarity) (PubMed:8950170). Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Inhibition of Prostaglandin-Degrading Enzyme 15-PGDH Mitigates Acute Murine Lung Allograft Rejection., [RefSeq, PubMed]; Smad4-deficient T cells promote colitis-associated colon cancer via an IFN-gamma-dependent suppression of 15-hydroxyprostaglandin dehydrogenase. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61106", "ec_number_list": "1.1.1.-;1.1.1.141;1.1.1.232", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0070403 NAD+ binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0004957 prostaglandin E receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:2001301 lipoxin biosynthetic process;GO:0032496 response to lipopolysaccharide;GO:0043065 positive regulation of apoptotic process;GO:0045471 response to ethanol;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VCC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YL7-1", "uniprot_id": "PG2IP_MOUSE", "mass": 78180.0, "length": 699, "protein_name": "PGAP2-interacting protein", "gene_name": "Cwh43", "organism": "Mouse", "refseq_name": "PGAP2-interacting protein isoform 1", "refseq_ac": "NP_851840", "gene_names_uniprotkb": "Cwh43; Pgap2ip", "gene_names_refseq": "C130090K23Rik; Cwh43; imds-60", "protein_names_uniprotkb": "PGAP2-interacting protein; Cell wall biogenesis protein 43 C-terminal homolog", "protein_names_refseq": "PGAP2-interacting protein isoform 1; PGAP2-interacting protein; cell wall biogenesis protein 43 C-terminal homolog", "tax_id": 10090, "disease": "normal pressure hydrocephalus (Disease Ontology:DOID:1572)", "pathway": " (mmu:231293)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17761529;18064386;34380733;35820727", "class_list": "", "function": "Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus., [RefSeq, PubMed]; Involved in lipid remodeling during GPI-anchor maturation., [UniProtKB, PubMed]; The imds-60 protein might play an important role in cell communication during sperm maturation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CBQ1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006509 membrane protein ectodomain proteolysis;GO:0007155 cell adhesion;GO:0050885 neuromuscular process controlling balance;GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91YL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921X9-1", "uniprot_id": "PDIA5_MOUSE", "mass": 59267.0, "length": 517, "protein_name": "Protein disulfide-isomerase A5", "gene_name": "Pdia5", "organism": "Mouse", "refseq_name": "protein disulfide-isomerase A5 precursor", "refseq_ac": "NP_082571", "gene_names_uniprotkb": "Pdia5; Pdir", "gene_names_refseq": "2700053F16Rik; Pdia5; Pdir", "protein_names_uniprotkb": "Protein disulfide-isomerase A5; 5.3.4.1; Protein disulfide isomerase-related protein", "protein_names_refseq": "protein disulfide isomerase-related protein; protein disulfide-isomerase A5 precursor; protein disulfide-isomerase A5", "tax_id": 10090, "disease": "", "pathway": " (mmu:72599)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22002444;31219806;34428180;36003400;37453647", "class_list": "", "function": "Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential Target for Immunotherapy. Publication Status: Online-Only, [RefSeq, PubMed]; Protein disulfide isomerase 5 is deregulated in the mucopolysaccharidoses, although the unfolded protein response is not activated, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q921X9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925I7-1", "uniprot_id": "PDGFD_MOUSE", "mass": 42809.0, "length": 370, "protein_name": "Platelet-derived growth factor D", "gene_name": "Pdgfd", "organism": "Mouse", "refseq_name": "platelet-derived growth factor D isoform 1 precursor", "refseq_ac": "NP_082200", "gene_names_uniprotkb": "Pdgfd; Scdgfb", "gene_names_refseq": "1110003I09Rik; Pdgfd", "protein_names_uniprotkb": "Platelet-derived growth factor D; PDGF-D; SCDGF-B; Spinal cord-derived growth factor B", "protein_names_refseq": "PDGF-D; SCDGF-B; platelet-derived growth factor D isoform 1 precursor; platelet-derived growth factor D; spinal cord-derived growth factor B", "tax_id": 10090, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); prostatic hypertrophy (Disease Ontology:DOID:11132); atherosclerosis (Disease Ontology:DOID:1936); glomerulonephritis (Disease Ontology:DOID:2921); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:71785); (R-MMU-186797)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11331881;11331882;11980634;12890490;14514732;14747375;15207812;15271796;36792607;37950842;38309427;38769116", "class_list": "", "function": "Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions. Publication Status: Online-Only, [RefSeq, PubMed]; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix., [UniProtKB, PubMed, PubMed, PubMed]; MicroRNA miR-145-5p Inhibits Cutaneous Wound Healing by Targeting PDGFD in Diabetic Foot Ulcer., [RefSeq, PubMed]; Molecular mechanisms of coronary artery disease risk at the PDGFD locus. Publication Status: Online-Only, [RefSeq, PubMed]; PDGF-D Is Dispensable for the Development and Progression of Murine Alport Syndrome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3URF6;Q8K2L3;Q9D1L8", "ec_number_list": "", "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0072126 positive regulation of glomerular mesangial cell proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q925I7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LC9-1", "uniprot_id": "PEX6_MOUSE", "mass": 104549.0, "length": 981, "protein_name": "Peroxisomal ATPase PEX6", "gene_name": "Pex6", "organism": "Mouse", "refseq_name": "peroxisomal ATPase PEX6", "refseq_ac": "NP_663463", "gene_names_uniprotkb": "Pex6", "gene_names_refseq": "D130055I09Rik; PAF-2; Pex6", "protein_names_uniprotkb": "Peroxisomal ATPase PEX6; 3.6.4.-; Peroxin-6; Peroxisomal biogenesis factor 6", "protein_names_refseq": "peroxin-6; peroxisomal ATPase PEX6; peroxisomal-type ATPase 1; peroxisome assembly factor 2", "tax_id": 10090, "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); peroxisome biogenesis disorder 4A (Disease Ontology:DOID:0080479); Heimler syndrome 2 (Disease Ontology:DOID:0080624); Peroxisome biogenesis disorder 4B (Disease Ontology:DOID:0081433); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (mmu:224824); (R-MMU-9033241)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "26593283;27302843;34428180", "class_list": "", "function": "Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6YNQ9", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;2.3.2.27;5.6.2.4;2.3.2.-;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;2.3.2.36;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005829 cytosol", "go_biological_process": "GO:0016561 protein import into peroxisome matrix, translocation;GO:0043335 protein unfolding;GO:0007031 peroxisome organization;GO:0050821 protein stabilization;GO:0006625 protein targeting to peroxisome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99LC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99NA9-1", "uniprot_id": "PCGF6_MOUSE", "mass": 39820.0, "length": 353, "protein_name": "Polycomb group RING finger protein 6", "gene_name": "Pcgf6", "organism": "Mouse", "refseq_name": "polycomb group RING finger protein 6 isoform 1", "refseq_ac": "NP_081930", "gene_names_uniprotkb": "Pcgf6; Mblr; Rnf134", "gene_names_refseq": "4933407A11Rik; MBLR; Pcgf6; Rnf134", "protein_names_uniprotkb": "Polycomb group RING finger protein 6; Mel18 and Bmi1-like RING finger; RING finger protein 134", "protein_names_refseq": "Mel18- and Bmi1-like RING finger protein; polycomb group RING finger protein 6 isoform 1; polycomb group RING finger protein 6; ring finger protein 134", "tax_id": 10090, "disease": "", "pathway": " (mmu:71041); (R-MMU-8953750)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12167161;21183079;21750661;22872234;31219806;33821003;35422437;38228142", "class_list": "", "function": "H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos., [RefSeq, PubMed]; PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression., [RefSeq, PubMed]; Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation by cell cycle-dependent phosphorylation, [RefSeq, PubMed]; Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031519 PcG protein complex;GO:0035102 PRC1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99NA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWM4-1", "uniprot_id": "PFD1_MOUSE", "mass": 14255.0, "length": 122, "protein_name": "Prefoldin subunit 1", "gene_name": "Pfdn1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Pfdn1", "gene_names_refseq": "", "protein_names_uniprotkb": "Prefoldin subunit 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0001540 amyloid-beta binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016272 prefoldin complex", "go_biological_process": "GO:0042113 B cell activation;GO:0030036 actin cytoskeleton organization;GO:0006457 protein folding;GO:0021549 cerebellum development;GO:0021537 telencephalon development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CWM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0B6-1", "uniprot_id": "PBDC1_MOUSE", "mass": 22223.0, "length": 198, "protein_name": "Protein PBDC1", "gene_name": "Pbdc1", "organism": "Mouse", "refseq_name": "protein PBDC1 isoform 2", "refseq_ac": "NP_001268800", "gene_names_uniprotkb": "Pbdc1", "gene_names_refseq": "2610029G23Rik; Pbdc1", "protein_names_uniprotkb": "Protein PBDC1; Polysaccharide biosynthesis domain-containing protein 1", "protein_names_refseq": "UPF0368 protein Cxorf26 homolog; protein PBDC1 isoform 2; protein PBDC1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67683)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18250455;22872234;25428506;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AUP5;Q8C5Z2;Q9CVL0", "ec_number_list": "", "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "", "go_biological_process": "GO:0051083 'de novo' cotranslational protein folding", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D0B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9G2-1", "uniprot_id": "PEBP4_MOUSE", "mass": 26858.0, "length": 242, "protein_name": "Phosphatidylethanolamine-binding protein 4", "gene_name": "Pebp4", "organism": "Mouse", "refseq_name": "phosphatidylethanolamine-binding protein 4 isoform a precursor", "refseq_ac": "NP_082836", "gene_names_uniprotkb": "Pebp4", "gene_names_refseq": "PEBP-4; Pebp4", "protein_names_uniprotkb": "Phosphatidylethanolamine-binding protein 4; PEBP-4", "protein_names_refseq": "phosphatidylethanolamine-binding protein 4 isoform a precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:73523)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17143548;27033522;35874667;38472560", "class_list": "", "function": "Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-kappaB Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; PEBP4 is a secreted protein and has multiple functions, including a role in Akt phosphorylation., [RefSeq, PubMed]; Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway., [UniProtKB, UniProtKB]; We describe the cloning and functional characterization of the mouse homolog of hPEBP4 (mPEBP4). We demonstrate that mPEBP4 promotes cellular migration and invasion by inhibiting ERK1/2 and JNK activation and up-regulating the expression of COX-2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3X8V3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D9G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JK30-1", "uniprot_id": "ORC3_MOUSE", "mass": 82342.0, "length": 715, "protein_name": "Origin recognition complex subunit 3", "gene_name": "Orc3", "organism": "Mouse", "refseq_name": "origin recognition complex subunit 3 isoform 2", "refseq_ac": "NP_001153035", "gene_names_uniprotkb": "Orc3; Orc3l", "gene_names_refseq": "Orc3l; Orc3", "protein_names_uniprotkb": "Origin recognition complex subunit 3; Origin recognition complex subunit Latheo", "protein_names_refseq": "origin of replication 3 homolog; origin recognition complex subunit 3 isoform 2; origin recognition complex subunit Latheo", "tax_id": 10090, "disease": "", "pathway": " (mmu:50793); (R-MMU-176187); (R-MMU-68616); (R-MMU-68689); (R-MMU-68949); (R-MMU-68962)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10702681;15634681;17525332;21750661;23110156;25428506;30084848;31219806;31599954;34428180;40885482", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3., [UniProtKB, UniProtKB]; Data indicate that conditional deletion from glial progenitors of orc3, a gene required for DNA replication, dramatically reduces glial progenitor cell number in the subventricular zone and astrocytes in the early postnatal cerebral cortex., [RefSeq, PubMed]; Mouse Orc1, Orc2, and Orc3 each exist in two alternative-splicing variants and naturally occurring Orc1B lacks a functional domain that is essential for nuclear translocation and proteasome-dependent degradation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AMF4;A2AMF5;Q6P8H2;Q8BR83;Q8C395", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005656 nuclear pre-replicative complex;GO:0031261 DNA replication preinitiation complex;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin", "go_biological_process": "GO:0006260 DNA replication;GO:0006275 regulation of DNA replication;GO:0006270 DNA replication initiation;GO:0061351 neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JK30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXX3-1", "uniprot_id": "PA2GX_MOUSE", "mass": 17005.0, "length": 151, "protein_name": "Group 10 secretory phospholipase A2", "gene_name": "Pla2g10", "organism": "Mouse", "refseq_name": "group 10 secretory phospholipase A2 isoform 1 preproprotein", "refseq_ac": "NP_036117", "gene_names_uniprotkb": "Pla2g10", "gene_names_refseq": "GX sPLA2; PLA2GX; Pla2g10; sPLA2-X", "protein_names_uniprotkb": "Group 10 secretory phospholipase A2; 3.1.1.4; GX sPLA2; Group X secretory phospholipase A2; Phosphatidylcholine 2-acylhydrolase 10; sPLA2-X", "protein_names_refseq": "group 10 secretory phospholipase A2 isoform 1 preproprotein; group 10 secretory phospholipase A2; group X secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:26565); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1482925); (R-MMU-1483166)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "10531313;11019817;11694541;11741598;12021277;12359733;17403936;20424324;21266581;21266583;27292189;29093264", "class_list": "", "function": "LDL modification by GXPLA2 [GXPLA2], [RefSeq, PubMed]; Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls (PubMed:10531313, PubMed:12359733). Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles (By similarity). Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (By similarity). Efficiently hydrolyzes and inactivates PAF, a potent lipid mediator present in oxidized LDL (By similarity). May act in an autocrine and paracrine manner. Secreted by lung epithelium, targets membrane phospholipids of infiltrating eosinophils, releasing arachidonate and boosting eicosanoid and cysteinyl leukotriene synthesis involved in airway inflammatory response (PubMed:17403936, PubMed:29093264). Secreted by gut epithelium, hydrolyzes dietary and biliary phosphatidylcholines in the gastrointestinal lumen, thereby regulating adipogenesis and body weight (PubMed:21266581). Plays a stem cell regulator role in colon epithelium. Within intracellular compartment, mediates Paneth-like cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ISC). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates the Wnt signaling pathway in ISCs and tissue regeneration (PubMed:27292189). May participate in hair follicle morphogenesis by regulating phosphatidylethanolamines metabolism at the outermost epithelial layer and facilitating melanin synthesis (PubMed:21266583). By generating lysophosphatidylcholines (LPCs) at sperm acrosome controls sperm cell capacitation, acrosome reaction and overall fertility (PubMed:20424324, PubMed:21266581). May promote neurite outgrowth in neuron fibers involved in nociception (PubMed:21266581). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria (PubMed:12359733). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541). In pulmonary epithelium, may contribute to host defense response against adenoviral infection. Prevents adenovirus entry into host cells by hydrolyzing host cell plasma membrane, releasing C16:0 LPCs that inhibit virus-mediated membrane fusion and viral infection. Likely prevents adenoviral entry into the endosomes of host cells (By similarity). May play a role in maturation and activation of innate immune cells including macrophages, group 2 innate lymphoid cells and mast cells (PubMed:29093264)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the phospholipase A2 family of lipolytic enzymes that hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. The encoded protein undergoes proteolytic processing to generate a calcium-dependent enzyme that plays pivotal roles in the liberation of arachidonic acid from membrane phospholipids leading to the production of various inflammatory lipid mediators, such as prostaglandins. In response to myocardial ischemia/reperfusion, mice lacking the encoded protein display a reduction in myocardial infarct size partly through the suppression of neutorphil cytotoxic activities. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQK6", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;3.1.1.5;3.1.2.2;3.1.1.3;3.1.1.47;2.3.1.-;3.1.1.-;3.1.1.32;2.3.1.149;2.3.1.51;3.1.1.23;3.1.-.-", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0004620 phospholipase activity;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0046473 phosphatidic acid metabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0051977 lysophospholipid transport;GO:0043249 erythrocyte maturation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QXX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZT4-1", "uniprot_id": "PA2GF_MOUSE", "mass": 18880.0, "length": 168, "protein_name": "Group IIF secretory phospholipase A2", "gene_name": "Pla2g2f", "organism": "Mouse", "refseq_name": "group IIF secretory phospholipase A2 isoform 1", "refseq_ac": "NP_036175", "gene_names_uniprotkb": "Pla2g2f", "gene_names_refseq": "GIIFsPLA2; Pla2g2f; sPLA2-IIF", "protein_names_uniprotkb": "Group IIF secretory phospholipase A2; 3.1.1.4; GIIF sPLA2; Phosphatidylcholine 2-acylhydrolase 2F; sPLA2-IIF", "protein_names_refseq": "GIIF sPLA2; group IIF secretory phospholipase A2 isoform 1; group IIF secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 2F", "tax_id": 10090, "disease": "", "pathway": " (mmu:26971); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1482925); (R-MMU-1483166)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "10531313;11877435", "class_list": "", "function": "Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:10531313). Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines (PubMed:10531313, PubMed:11877435). May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (PubMed:10531313)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CE14", "ec_number_list": "1.11.1.27;3.1.1.4;2.3.1.23;3.1.1.5;3.1.2.2;3.1.1.3;2.3.1.-;3.1.1.-;3.1.1.32;2.3.1.51;3.1.1.23;3.1.-.-", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0036148 phosphatidylglycerol acyl-chain remodeling;GO:0045087 innate immune response;GO:0016042 lipid catabolic process;GO:0042130 negative regulation of T cell proliferation;GO:0050482 arachidonate secretion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZT4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70169-1", "uniprot_id": "PRS39_MOUSE", "mass": 40766.0, "length": 367, "protein_name": "Inactive serine protease 39", "gene_name": "Prss39", "organism": "Mouse", "refseq_name": "inactive serine protease 39 isoform 1 precursor", "refseq_ac": "NP_033381", "gene_names_uniprotkb": "Prss39; Tesp1", "gene_names_refseq": "Prss39; Tesp1", "protein_names_uniprotkb": "Inactive serine protease 39; Inactive testicular serine protease 1", "protein_names_refseq": "inactive serine protease 39 isoform 1 precursor; inactive serine protease 39; inactive testicular serine protease 1; protease, serine 39", "tax_id": 10090, "disease": "", "pathway": " (mmu:21755)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34524424;9588171", "class_list": "", "function": "A mouse testis serine protease, TESP1, as the potential SPINK3 receptor protein on mouse sperm acrosome., [RefSeq, PubMed]; May play an important role in the sperm/egg interaction; released during the acrosome reaction., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80YD5", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70169-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97470-1", "uniprot_id": "PP4C_MOUSE", "mass": 35080.0, "length": 307, "protein_name": "Serine/threonine-protein phosphatase 4 catalytic subunit", "gene_name": "Ppp4c", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase 4 catalytic subunit", "refseq_ac": "NP_062648", "gene_names_uniprotkb": "Ppp4c; Ppp4; Ppx", "gene_names_refseq": "1110002D08Rik; PP-X; PP4C; Ppp4c; Ppx; pp4", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 catalytic subunit; 3.1.3.16; PP-X; PP4C; Pp4; Protein phosphatase X", "protein_names_refseq": "protein phosphatase X; serine/threonine-protein phosphatase 4 catalytic subunit", "tax_id": 10090, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (mmu:56420); (R-MMU-5693607)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11707325;12934076;18347064;18715871;21750661;31219806;34428180;38424148;9837938", "class_list": "", "function": "AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner., [RefSeq, PubMed]; Protein phosphatase 4 has a role in apoptosis., [RefSeq, PubMed]; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair (By similarity). Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9876, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P33172", "ec_number_list": "3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0044877 protein-containing complex binding;GO:0005521 lamin binding;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0016311 dephosphorylation;GO:0001933 negative regulation of protein phosphorylation;GO:0000724 double-strand break repair via homologous recombination;GO:0010569 regulation of double-strand break repair via homologous recombination;GO:2000779 regulation of double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P97470-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61458-1", "uniprot_id": "PHS_MOUSE", "mass": 11986.0, "length": 104, "protein_name": "Pterin-4-alpha-carbinolamine dehydratase", "gene_name": "Pcbd1", "organism": "Mouse", "refseq_name": "pterin-4-alpha-carbinolamine dehydratase", "refseq_ac": "NP_079549", "gene_names_uniprotkb": "Pcbd1; Dcoh; Pcbd", "gene_names_refseq": "Dcoh; Pcbd1; Pcbd; Pcd; Phs", "protein_names_uniprotkb": "Pterin-4-alpha-carbinolamine dehydratase; 4-alpha-hydroxy-tetrahydropterin dehydratase; 4.2.1.96; DCoH; Dimerization cofactor of HNF1; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; PCD; PHS; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase", "protein_names_refseq": "4-alpha-hydroxy-tetrahydropterin dehydratase; 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); dimerization cofactor of HNF1; phenylalanine hydroxylase-stimulating protein; pterin carbinolamine dehydratase; pterin-4-alpha-carbinolamine dehydratase", "tax_id": 10090, "disease": "BH4-deficient hyperphenylalaninemia D (Disease Ontology:DOID:0081131)", "pathway": " (mmu:13180); (R-MMU-8964208)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12011081;15182178;1763325;21750661;24204001;34428180", "class_list": "", "function": "DCoH acts as a cofactor for HNF1 that stabilizes the dimeric HNF1 complex. GeneRIF: Mouse Pcbd1 is a moonlighting protein that has dehydratase activity in addition to functioning as a cofactor which regulates HNF1alpha., [RefSeq, PubMed]; HNF1alpha binding kinetics may distinguish regulation by DCoH2, under thermodynamic control, from regulation by DCoH, under kinetic control, [RefSeq, PubMed]; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Also acts as a coactivator for HNF1B-dependent transcription (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70519;P80095;Q9D930", "ec_number_list": "4.2.1.96", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity;GO:0004505 phenylalanine 4-monooxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0006729 tetrahydrobiopterin biosynthetic process;GO:0006558 L-phenylalanine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P61458-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z0R2-1", "uniprot_id": "PPR36_MOUSE", "mass": 47354.0, "length": 411, "protein_name": "Protein phosphatase 1 regulatory subunit 36", "gene_name": "Ppp1r36", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 36", "refseq_ac": "NP_001156575", "gene_names_uniprotkb": "Ppp1r36; Gm70", "gene_names_refseq": "Gm70; Ppp1r36", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 36", "protein_names_refseq": "protein phosphatase 1 regulatory subunit 36", "tax_id": 10090, "disease": "", "pathway": " (mmu:210762)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17971504;21750661", "class_list": "", "function": "Gm70 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity;GO:0019902 phosphatase binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z0R2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04768-1", "uniprot_id": "PR2C3_MOUSE", "mass": 25338.0, "length": 224, "protein_name": "Prolactin-2C3", "gene_name": "Prl2c3", "organism": "Mouse", "refseq_name": "prolactin-2C3 precursor", "refseq_ac": "NP_035248", "gene_names_uniprotkb": "Prl2c3; Mrp2; Mrp3; Mrpplf3; Plf2; Plf3; Prl2c4", "gene_names_refseq": "Ghd1; MRP-2; MRP-3; Mrpplf3; PLF-2; PLF-3; Plf2; Prl2c3; Prl2c4; mrp/plf3", "protein_names_uniprotkb": "Prolactin-2C3; Mitogen-regulated protein 2; Mitogen-regulated protein 3; Prolactin-2C4; Proliferin-2; Proliferin-3", "protein_names_refseq": "growth hormone d1; mitogen-regulated protein 2; mitogen-regulated protein 3; prolactin-2C3 precursor; prolactin-2C3; prolactin-2C4; proliferin-2; proliferin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:18812); (mmu:26421)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10537154;11316781;16876275;21750661;2790033;3859868;8043949", "class_list": "", "function": "May have a role in embryonic development. It is likely to provide a growth stimulus to target cells in maternal and fetal tissues during the development of the embryo at mid-gestation. May play a role during wound healing and in the hair follicle cycle as a growth factor and/or an angiogenesis factor. May play a role in microvilli formation and cell proliferation of neuroblastoma cells., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P18918;Q498A5;Q6PDB6", "ec_number_list": "", "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04768-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09586-1", "uniprot_id": "PR3B1_MOUSE", "mass": 25159.0, "length": 222, "protein_name": "Prolactin-3B1", "gene_name": "Prl3b1", "organism": "Mouse", "refseq_name": "prolactin-3B1 precursor", "refseq_ac": "NP_032891", "gene_names_uniprotkb": "Prl3b1; Csh2; Pl-2; Pl2", "gene_names_refseq": "Csh2; Ghd8; PL; Pl-2; Pl2; Prl3b1; mPL-II; mplII", "protein_names_uniprotkb": "Prolactin-3B1; Chorionic somatomammotropin hormone 2; PL-II; Placental lactogen II", "protein_names_refseq": "PL-II; chorionic somatomammotropin hormone 2; growth hormone d8; placental lactogen 2; placental lactogen II; prolactin-3B1 precursor; prolactin-3B1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18776)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1570305;21750661;3464966;3859868", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P09586-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AJ77-1", "uniprot_id": "PRD12_MOUSE", "mass": 40303.0, "length": 365, "protein_name": "PR domain zinc finger protein 12", "gene_name": "Prdm12", "organism": "Mouse", "refseq_name": "PR domain zinc finger protein 12", "refseq_ac": "NP_001116834", "gene_names_uniprotkb": "Prdm12; Gm998", "gene_names_refseq": "Gm998; Prdm12", "protein_names_uniprotkb": "PR domain zinc finger protein 12; PR domain-containing protein 12", "protein_names_refseq": "PR domain zinc finger protein 12; PR domain-containing protein 12", "tax_id": 10090, "disease": "hereditary sensory and autonomic neuropathy type 8 (Disease Ontology:DOID:0070153)", "pathway": " (mmu:381359)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23856557;26005867;30917305;33789102;34961757", "class_list": "", "function": "Prdm12 is induced by the retinoic acid signaling in vivo, and may regulate neural differentiation during animal development., [RefSeq, PubMed]; Transcriptional regulator necessary for the development of nociceptive neurons, playing a key role in determining the nociceptive lineage from neural crest cell progenitors (PubMed:30917305, PubMed:33789102). Initiates neurogenesis and activates downstream pro-neuronal transcription factors, such as NEUROD1, BRN3A, and ISL1, specifically within nociceptive neurons, while repressing non-nociceptor cell fates (PubMed:30917305). Essential for the proper function of nociceptors in adults, influencing both their excitability and their gene expression, thereby impacting how these neurons respond to various pain stimuli (PubMed:34961757)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0031175 neuron projection development;GO:0019233 sensory perception of pain;GO:0050965 detection of temperature stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2AJ77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AR02-1", "uniprot_id": "PPIG_MOUSE", "mass": 88325.0, "length": 752, "protein_name": "Peptidyl-prolyl cis-trans isomerase G", "gene_name": "Ppig", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase G isoform 1", "refseq_ac": "NP_001074555", "gene_names_uniprotkb": "Ppig", "gene_names_refseq": "B230312B02Rik; CYP; Ppig; SRCyp", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase G; 5.2.1.8; Cyclophilin G; PPIase G; Peptidyl-prolyl isomerase G; Rotamase G", "protein_names_refseq": "PPIase G; cyclophilin G; peptidyl-prolyl cis-trans isomerase G isoform 1; peptidyl-prolyl cis-trans isomerase G; peptidylprolyl isomerase G; rotamase G", "tax_id": 10090, "disease": "", "pathway": " (mmu:228005); (R-MMU-72163)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21183079;21750661;28528544", "class_list": "", "function": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing., [UniProtKB, UniProtKB]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70134;Q3TP68;Q3UXE0", "ec_number_list": "3.6.4.13;5.2.1.8;3.1.13.-;2.7.7.48;2.7.7.6;3.6.4.10;2.3.2.27", "go_molecular_function": "GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2AR02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35655-1", "uniprot_id": "PPE1_MOUSE", "mass": 75058.0, "length": 650, "protein_name": "Serine/threonine-protein phosphatase with EF-hands 1", "gene_name": "Ppef1", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase with EF-hands 1", "refseq_ac": "NP_035277", "gene_names_uniprotkb": "Ppef1; Dres10; Ppef", "gene_names_refseq": "PPEF-1; Ppef1", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase with EF-hands 1; 3.1.3.16; DRES10; PPEF-1; PPEF; Protein phosphatase with EF calcium-binding domain", "protein_names_refseq": "DRES10; PPEF 1; protein phosphatase with EF calcium-binding domain; serine/threonine-protein phosphatase with EF-hands 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:237178); (R-MMU-2514859)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;25428506;28051100;33783058;9215685", "class_list": "", "function": "Dephosphorylates and destabilises PDCD5 to inhibit TP53/p53-mediated signaling (PubMed:28051100). May have a role in the recovery or adaptation response of photoreceptors (By similarity)., [UniProtKB, PubMed, UniProtKB]; The protein phosphatase with EF-hand domain 1 is a calmodulin-binding protein that interacts with proteins involved in sperm capacitation, binding to the zona pellucida, and motility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AIC6", "ec_number_list": "3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0005506 iron ion binding;GO:0030145 manganese ion binding;GO:0005509 calcium ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0050906 detection of stimulus involved in sensory perception", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35655-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35396-1", "uniprot_id": "PPARD_MOUSE", "mass": 49715.0, "length": 440, "protein_name": "Peroxisome proliferator-activated receptor delta", "gene_name": "Ppard", "organism": "Mouse", "refseq_name": "peroxisome proliferator-activated receptor delta isoform 1", "refseq_ac": "NP_035275", "gene_names_uniprotkb": "Ppard; Nr1c2; Pparb", "gene_names_refseq": "NUC-1; NUC1; Nr1c2; PPAR-beta; PPAR-delta; PPAR[b]; PPARdelta; Pparb/d; Pparb; Ppard", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor delta; NUC1; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; PPAR-beta; PPAR-delta; Peroxisome proliferator-activated receptor beta", "protein_names_refseq": "PPARdelta/beta; Peroxisome proliferator-activated receptor beta; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2; peroxisome proliferator-activated receptor delta isoform 1; peroxisome proliferator-activated receptor delta", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858); pancreatic cancer (Disease Ontology:DOID:1793); biliary tract cancer (Disease Ontology:DOID:4607); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:19015); (R-MMU-200425); (R-MMU-383280); (R-MMU-5362517)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "18299400;20173027;20484733;21750661;21952136;25428506;25428507;27802388;28683290;28751364;30084848;30779550;34428180;35675826;35820727;38656552;39292167;7836471;8041794;8240342", "class_list": "", "function": "Inhibitory Regulation of FOXO1 in PPARdelta Expression Drives Mitochondrial Dysfunction and Insulin Resistance., [RefSeq, PubMed]; Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues (PubMed:35675826). Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity)., [UniProtKB, PubMed, UniProtKB]; Peroxisome Proliferator-Activated Receptor delta Suppresses the Cytotoxicity of CD8+ T Cells by Inhibiting RelA DNA-Binding Activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P37239", "ec_number_list": "", "go_molecular_function": "GO:0016501 prostacyclin receptor activity;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0005504 fatty acid binding;GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0051546 keratinocyte migration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P35396-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PZZ1-1", "uniprot_id": "PRD13_MOUSE", "mass": 78705.0, "length": 754, "protein_name": "PR domain zinc finger protein 13", "gene_name": "Prdm13", "organism": "Mouse", "refseq_name": "PR domain zinc finger protein 13", "refseq_ac": "NP_001074240", "gene_names_uniprotkb": "Prdm13", "gene_names_refseq": "Prdm13", "protein_names_uniprotkb": "PR domain zinc finger protein 13; 2.1.1.-; PR domain-containing protein 13", "protein_names_refseq": "PR domain zinc finger protein 13; PR domain-containing protein 13", "tax_id": 10090, "disease": "pontocerebellar hypoplasia (Disease Ontology:DOID:0060264); North Carolina macular dystrophy (Disease Ontology:DOID:0070439)", "pathway": " (mmu:230025)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25546159;25995483;34730112;37045472", "class_list": "", "function": "Findings indicate that Prdm13/Nkx2-1-mediated signaling in the DMC declines with advanced age, leading to decreased sleep quality and increased adiposity., [RefSeq, PubMed]; May be involved in transcriptional regulation. Is required for the differentiation of Kiss1-expressing neurons in the arcuate (Arc) nucleus of the hypothalamus. Is a critical regulator of GABAergic cell fate in the cerebellum, required for normal postnatal cerebellar development (PubMed:34730112)., [UniProtKB, PubMed]; Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Targeted deletion of Prdm13 leads to a specific reduction of amacrine cells and changes visual sensitivity., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1AV74", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042054 histone methyltransferase activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010468 regulation of gene expression;GO:0032259 methylation;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9PZZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54830-1", "uniprot_id": "PR7A1_MOUSE", "mass": 29828.0, "length": 266, "protein_name": "Prolactin-7A1", "gene_name": "Prl7a1", "organism": "Mouse", "refseq_name": "prolactin-7A1 isoform 1 precursor", "refseq_ac": "NP_001157530", "gene_names_uniprotkb": "Prl7a1; Prlpe; Prlpg", "gene_names_refseq": "PLP-E; PLP-G; Prl7a1; Prlpe; Prlpg", "protein_names_uniprotkb": "Prolactin-7A1; PLP-E; PLP-G; PRL-like protein E; PRL-like protein G; Placental prolactin-like protein E; Placental prolactin-like protein G", "protein_names_refseq": "PRL-like protein E; PRL-like protein G; placental prolactin-like protein E; placental prolactin-like protein G; prolactin-7A1 isoform 1 precursor; prolactin-7A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19113)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12040023;12399423;9389541;9545574", "class_list": "", "function": "Injection of PLP-E into thrombocytopenic mice restores normal platelet levels with no effect on granulocytes, erythrocytes, and total white blood cell counts, [RefSeq, PubMed]; Results show that PRL-like proteins E and F have the same stimulatory effects on megakaryocyte growth and differentiation, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O35334;Q80X21", "ec_number_list": "", "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O54830-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08399-1", "uniprot_id": "PHXR5_MOUSE", "mass": 57923.0, "length": 672, "protein_name": "Putative per-hexamer repeat protein 5", "gene_name": "Phxr5", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Phxr5; Per", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative per-hexamer repeat protein 5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2413365", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P08399-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15973-1", "uniprot_id": "PHXR1_MOUSE", "mass": 6756.0, "length": 60, "protein_name": "Putative per-hexamer repeat protein 1", "gene_name": "Phxr1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Phxr1", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative per-hexamer repeat protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3267239", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P15973-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24823-1", "uniprot_id": "PPBN_MOUSE", "mass": 57202.0, "length": 529, "protein_name": "Alkaline phosphatase, germ cell type", "gene_name": "Alpg", "organism": "Mouse", "refseq_name": "alkaline phosphatase, germ cell type precursor", "refseq_ac": "NP_031459", "gene_names_uniprotkb": "Alpg; Akp5; Alppl2; Eap", "gene_names_refseq": "Akp5; Alpg; Alppl2; D1Ertd816e; EAP", "protein_names_uniprotkb": "Alkaline phosphatase, germ cell type; 3.1.3.1; Alkaline phosphatase 5; Alkaline phosphatase, placental-like; EAP; Embryonic alkaline phosphatase; Embryonic-type alkaline phosphatase", "protein_names_refseq": "alkaline phosphatase 5; alkaline phosphatase, germ cell type precursor; alkaline phosphatase, germ cell type; embryonic alkaline phosphatase; embryonic-type alkaline phosphatase", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (mmu:11650); (R-MMU-163125); (R-MMU-6811438)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "2286375;9056646", "class_list": "", "function": "Alkaline phosphatase that can hydrolyze various phosphate compounds., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULC9", "ec_number_list": "3.4.11.9;3.1.3.2;3.1.3.48;3.1.3.1;3.1.4.50;3.9.1.1;3.6.5.2;3.2.2.6;3.4.17.12;3.1.3.5;2.4.2.31;3.4.21.-;3.5.1.92", "go_molecular_function": "GO:0004035 alkaline phosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P24823-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30412-1", "uniprot_id": "PPIC_MOUSE", "mass": 22794.0, "length": 212, "protein_name": "Peptidyl-prolyl cis-trans isomerase C", "gene_name": "Ppic", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase C precursor", "refseq_ac": "NP_032934", "gene_names_uniprotkb": "Ppic; Cypc", "gene_names_refseq": "CyP-20c; Ppic", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase C; 5.2.1.8; Cyclophilin C; PPIase C; Rotamase C", "protein_names_refseq": "PPIase C; cyclophilin C; peptidyl-prolyl cis-trans isomerase C precursor; peptidyl-prolyl cis-trans isomerase C; rotamase C", "tax_id": 10090, "disease": "", "pathway": " (mmu:19038)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1652374;25428506;30084848;31219806;33864384;34428180;8265636", "class_list": "", "function": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding., [UniProtKB, PubMed]; Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iNKT) differentiation in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P30412-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31361-1", "uniprot_id": "PO3F3_MOUSE", "mass": 50200.0, "length": 497, "protein_name": "POU domain, class 3, transcription factor 3", "gene_name": "Pou3f3", "organism": "Mouse", "refseq_name": "POU domain, class 3, transcription factor 3", "refseq_ac": "NP_032926", "gene_names_uniprotkb": "Pou3f3; Brn-1; Brn1; Otf8", "gene_names_refseq": "Brn-1; Brn1; HST011; Otf8; Pou3f3; Skin1; urehr2", "protein_names_uniprotkb": "POU domain, class 3, transcription factor 3; Brain-1; Brain-specific homeobox/POU domain protein 1; Brn-1; OTF-8; Oct-8; Octamer-binding protein 8; Octamer-binding transcription factor 8", "protein_names_refseq": "OTF-8; POU domain, class 3, transcription factor 3; brain-1; brain-specific homeobox/POU domain protein 1; oct-8; octamer-binding protein 8; octamer-binding transcription factor 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:18993)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10473120;11859196;12130536;1565620;19527706;35820727;39271675", "class_list": "", "function": "Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that acts synergistically with SOX11 and SOX4 (By similarity). Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3')., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0021869 forebrain ventricular zone progenitor cell division;GO:0071918 urea transmembrane transport;GO:0072218 metanephric ascending thin limb development;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P31361-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33610-1", "uniprot_id": "PRI2_MOUSE", "mass": 58408.0, "length": 505, "protein_name": "DNA primase large subunit", "gene_name": "Prim2", "organism": "Mouse", "refseq_name": "DNA primase large subunit isoform 1", "refseq_ac": "NP_032948", "gene_names_uniprotkb": "Prim2", "gene_names_refseq": "Prim2", "protein_names_uniprotkb": "DNA primase large subunit; DNA primase 58 kDa subunit; p58", "protein_names_refseq": "DNA primase 58 kDa subunit; DNA primase large subunit isoform 1; DNA primase large subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:19076); (R-MMU-113501); (R-MMU-174411); (R-MMU-174430); (R-MMU-68952); (R-MMU-68962); (R-MMU-69091); (R-MMU-69166); (R-MMU-69183)", "pathway_count": 9, "publication_count": 10, "publication_id_list": "22872234;25428506;30084848;31219806;34203471;34428180;36210013;8026492;8253737;8463324", "class_list": "", "function": "Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:8026492, PubMed:8253737). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:8253737). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:8253737). Binds RNA:DNA duplex and coordinates the catalytic activities of PRIM1 and POLA2 during primase-to-polymerase switch., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4Z3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003899 DNA-directed RNA polymerase activity;GO:0071667 DNA/RNA hybrid binding", "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006270 DNA replication initiation;GO:0006269 DNA replication, synthesis of primer", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P33610-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P99026-1", "uniprot_id": "PSB4_MOUSE", "mass": 29116.0, "length": 264, "protein_name": "Proteasome subunit beta type-4", "gene_name": "Psmb4", "organism": "Mouse", "refseq_name": "proteasome subunit beta type-4", "refseq_ac": "NP_032971", "gene_names_uniprotkb": "Psmb4; Lmp3", "gene_names_refseq": "Pros-27; Psmb4", "protein_names_uniprotkb": "Proteasome subunit beta type-4; Low molecular mass protein 3; Macropain beta chain; Multicatalytic endopeptidase complex beta chain; Proteasome beta chain; Proteasome chain 3; Proteasome subunit beta-7; beta-7", "protein_names_refseq": "beta-7; low molecular mass protein 3; macropain beta chain; multicatalytic endopeptidase complex beta chain; proteasome beta chain; proteasome chain 3; proteasome subunit beta type-4; proteasome subunit beta-7", "tax_id": 10090, "disease": "proteasome-associated autoinflammatory syndrome 3 (Disease Ontology:DOID:0060916)", "pathway": " (mmu:19172); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 58, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12874245;16317774;16581775;16857966;22341445;25428506;28011936;28315936;34428180;35984892;37828378;9197541", "class_list": "", "function": "Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3THC0;Q3THI3;Q3U0S0;Q3UVQ4;Q62008;Q8BK27;Q91VV7", "ec_number_list": "", "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0002862 negative regulation of inflammatory response to antigenic stimulus;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P99026-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00LT2-1", "uniprot_id": "PRCD_MOUSE", "mass": 5931.0, "length": 53, "protein_name": "Photoreceptor disk component PRCD", "gene_name": "Prcd", "organism": "Mouse", "refseq_name": "photoreceptor disk component PRCD", "refseq_ac": "NP_001156790", "gene_names_uniprotkb": "Prcd; Gm11744", "gene_names_refseq": "Gm11744; Prcd", "protein_names_uniprotkb": "Photoreceptor disk component PRCD; Progressive rod-cone degeneration protein homolog", "protein_names_refseq": "photoreceptor disk component PRCD; progressive rod cone degeneration protein; progressive rod-cone degeneration protein homolog", "tax_id": 10090, "disease": "retinitis pigmentosa 36 (Disease Ontology:DOID:0110405)", "pathway": " (mmu:100038570)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16938425;23672200;27509380;27613864;30779550;31189593;31628458;33087780;33213002", "class_list": "", "function": "Demonstrated this interaction to be critically important for supporting the intracellular stability of PRCD, as the knockout of rhodopsin caused a drastic reduction in the photoreceptor content of PRCD, [RefSeq, PubMed]; Disrupting PRCD palmitoylation eliminating the modified cysteine dramatically affects the stability of PRCD., [RefSeq, PubMed]; Involved in vision., [UniProtKB, UniProtKB]; Loss of PRCD alters number and packaging density of rhodopsin in rod photoreceptor disc membranes. Publication Status: Online-Only, [RefSeq, PubMed]; Study in Prcd knockout mice found that Prcd functions at the site of photoreceptor disc morphogenesis where it is required to keep newly forming discs flat as they protrude from the plasma membrane. Without Prcd, the newly forming discs bulge and release extracellular vesicles, which accumulate in the extracellular space and ultimately lead to retinal pathology., [RefSeq, PubMed]; TULP1 and TUB Are Required for Specific Localization of PRCD to Photoreceptor Outer Segments. Publication Status: Online-Only, [RefSeq, PubMed]; This study has important implications for understanding the function of PRCD in the retina, as well as for future development of treatment modalities for PRCD deficiency in humans., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002046 opsin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0050908 detection of light stimulus involved in visual perception", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q00LT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05117-1", "uniprot_id": "PPA5_MOUSE", "mass": 36807.0, "length": 327, "protein_name": "Tartrate-resistant acid phosphatase type 5", "gene_name": "Acp5", "organism": "Mouse", "refseq_name": "tartrate-resistant acid phosphatase type 5 precursor", "refseq_ac": "NP_001095874", "gene_names_uniprotkb": "Acp5; T5ap; Trap", "gene_names_refseq": "Acp5; TRACP; TRAP", "protein_names_uniprotkb": "Tartrate-resistant acid phosphatase type 5; 3.1.3.2; TR-AP; Tartrate-resistant acid ATPase; TrATPase; Type 5 acid phosphatase", "protein_names_refseq": "TR-AP; acid phosphatase type V; tartrate-resistant acid ATPase; tartrate-resistant acid phosphatase type 5 precursor; tartrate-resistant acid phosphatase type 5; trATPase; type 5 acid phosphatase", "tax_id": 10090, "disease": "spondylometaphyseal dysplasia (Disease Ontology:DOID:0112295)", "pathway": " (mmu:11433); (R-MMU-196843)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21913724;23478294;26495903;34428180;37453647;39111379;40997131;8256664;8359686", "class_list": "", "function": "May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates., [UniProtKB]; Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes bone length, regulates cortical and trabecular bone mass, and maintains growth plate architecture and width in a sex- and site-specific manner in mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.2;3.1.3.48;3.1.3.1;3.9.1.1;3.1.3.5", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003993 acid phosphatase activity;GO:0008198 ferrous iron binding;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0016311 dephosphorylation;GO:0007162 negative regulation of cell adhesion;GO:0030335 positive regulation of cell migration;GO:0032496 response to lipopolysaccharide;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q05117-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07916-4", "uniprot_id": "PO6F1_MOUSE", "mass": 59844.0, "length": 576, "protein_name": "POU domain, class 6, transcription factor 1", "gene_name": "Pou6f1", "organism": "Mouse", "refseq_name": "POU domain, class 6, transcription factor 1 isoform 1", "refseq_ac": "NP_001291894", "gene_names_uniprotkb": "Pou6f1; Emb", "gene_names_refseq": "2310038G18Rik; Emb; Pou6f1; cns-1", "protein_names_uniprotkb": "POU domain, class 6, transcription factor 1; Octamer-binding transcription factor EMB; Transcription regulatory protein MCP-1", "protein_names_refseq": "POU domain, class 6, transcription factor 1 isoform 1; octamer-binding transcription factor EMB; transcription regulatory protein MCP-1", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:19009)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15024082;29305536;36724075;7907365;8463278", "class_list": "", "function": "POU6f1 is necessary for proper dendrite specification and patterning, as well as synapse development and function in adult-born neurons, [RefSeq, PubMed]; RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation., [RefSeq, PubMed]; These results demonstrate the importance of the Emb-MEF2D-histone transacetylase p300 complex in the transcriptional regulation of the cardiac actin gene and suggest a potential role in chromatin remodeling associated with muscle gene activation., [RefSeq, PubMed]; Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3')., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5U4D4;Q91XK3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q07916-4", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UTQ7-1", "uniprot_id": "PRD10_MOUSE", "mass": 133746.0, "length": 1184, "protein_name": "PR domain zinc finger protein 10", "gene_name": "Prdm10", "organism": "Mouse", "refseq_name": "PR domain zinc finger protein 10 isoform 3", "refseq_ac": "NP_001398366", "gene_names_uniprotkb": "Prdm10; Gm1112; Tris", "gene_names_refseq": "Gm1112; Prdm10; tristanin", "protein_names_uniprotkb": "PR domain zinc finger protein 10; PR domain-containing protein 10; Tristanin", "protein_names_refseq": "PR domain zinc finger protein 10 isoform 3; PR domain zinc finger protein 10; PR domain-containing protein 10", "tax_id": 10090, "disease": "Birt-Hogg-Dube syndrome (Disease Ontology:DOID:0050676)", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "12175877;17525332;20132732;21750661;21913724;25428506;32681107;33809237;34562314;40997131", "class_list": "", "function": "Down-regulation of PR/SET domain 10 underlies natural killer cell dysfunction in hepatocellular carcinoma., [RefSeq, PubMed]; Global translation during early development depends on the essential transcription factor PRDM10. Publication Status: Online-Only, [RefSeq, PubMed]; Investigation of PRDM10 and PRDM13 Expression in Developing Mouse Embryos by an Optimized PACT-Based Embryo Clearing Method. Publication Status: Online-Only, [RefSeq, PubMed]; PRDM10 might be a transcriptional regulator for normal tissue differentiation during mouse embryonic development., [RefSeq, PubMed]; Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (PubMed:32681107). Supports cell growth and survival during early development by transcriptionally activating the expression of the translation initiation factor EIF3B, to sustain global translation (PubMed:32681107). Activates the transcription of FLNC (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6P397", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3UTQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q52KR3-1", "uniprot_id": "PRUN2_MOUSE", "mass": 339516.0, "length": 3084, "protein_name": "Protein prune homolog 2", "gene_name": "Prune2", "organism": "Mouse", "refseq_name": "protein prune homolog 2", "refseq_ac": "NP_851993", "gene_names_uniprotkb": "Prune2; Bmcc1; Kiaa0367", "gene_names_refseq": "6330414G02Rik; A230083H22Rik; A330102H22Rik; Bmcc1; Olfaxin; Prune2; mKIAA0367", "protein_names_uniprotkb": "Protein prune homolog 2; BNIP2 motif-containing molecule at the C-terminal region 1", "protein_names_refseq": "BNIP2 motif-containing molecule at the C-terminal region 1; neuronal protein; protein prune homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:353211)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16288218;21893162;23059019;23246912;25428506;29571668;30084848;31219806;34203471", "class_list": "", "function": "Kidney-type glutaminase (KGA) as a novel partner of Bmcc1s, [RefSeq, PubMed]; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells., [UniProtKB]; Prune2 mRNA is predominantly expressed in the neurons of the cranial nerve motor nuclei and the motor neurons of the spinal cord, [RefSeq, PubMed]; Study shows that odor preference and olfactory memory are impaired in Prune 2deficient mice. Knockout of Prune2 leads to a decrease in the Prune2 protein isoform Olfaxin. Levels of Olfaxin mRNA were decreased., [RefSeq, PubMed]; We showed that Olfaxin, a novel Prune2 isoform contains a BCH motif and localizes predominantly to the synaptic cytosol in the olfactory bulb and layer Ia of the piriform cortex., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q501M3;Q6A079;Q8BW65;Q8BYM6;Q9D217", "ec_number_list": "", "go_molecular_function": "GO:0016462 pyrophosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0098793 presynapse", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q52KR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5M8S2-1", "uniprot_id": "PRS46_MOUSE", "mass": 35185.0, "length": 314, "protein_name": "Serine protease 46", "gene_name": "Prss46", "organism": "Mouse", "refseq_name": "serine protease 46", "refseq_ac": "NP_898926", "gene_names_uniprotkb": "Prss46", "gene_names_refseq": "1700112C13Rik; 79H19B; Prss46; Tessp6", "protein_names_uniprotkb": "Serine protease 46; 3.4.21.-", "protein_names_refseq": "protease, serine 46; serine protease 46; testis serine protease 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:74306)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31403672", "class_list": "", "function": "The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertilitydagger., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1Q8", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M8S2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C4Y3-3", "uniprot_id": "NELFB_MOUSE", "mass": 70339.0, "length": 631, "protein_name": "Negative elongation factor B", "gene_name": "Nelfb", "organism": "Mouse", "refseq_name": "negative elongation factor B isoform 2", "refseq_ac": "NP_001297086", "gene_names_uniprotkb": "Nelfb; Cobra1; MNCb-5210", "gene_names_refseq": "A730008L03Rik; Cobra1; Nelf-b; Nelfb", "protein_names_uniprotkb": "Negative elongation factor B; Cofactor of BRCA1; NELF-B", "protein_names_refseq": "negative elongation factor B isoform 2; negative elongation factor complex member B, Cobra1; ortholog of human cofactor of BRCA1 (COBRA1)", "tax_id": 10090, "disease": "", "pathway": " (mmu:58202); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6796648); (R-MMU-75955)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "15345747;19340312;21865163;24034695;24656816;25773599;26010750;37717699", "class_list": "", "function": "An essential signaling function of cytoplasmic NELFB is independent of RNA polymerase II pausing., [RefSeq, PubMed]; Both human and mouse NELF-B proteins are translated from a non-AUG codon upstream of the annotated AUG. GeneRIF: Human and mouse Nelfb encode proteins translated from a non-AUG (CUG) start codon. The majority of mouse tissues examined express the isoform translated from the CUG start codon, but a small number of tissues also express a shorter isoform of the same apparent size as the AUG-initiated isoform. Publication Status: Online-Only, [RefSeq, PubMed]; Cobra1 Is Required for TrkC-Induced Apoptosis., [RefSeq, PubMed]; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (Pol II) (PubMed:25773599). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). May be able to induce chromatin unfolding (By similarity). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (PubMed:19340312). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (PubMed:25773599). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes (PubMed:24656816)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Findings also indicate that Cobra1 helps maintain the undifferentiated state of mESCs by preventing unscheduled expression of developmental genes, [RefSeq, PubMed]; Genetic and genomic studies provide new physiological and molecular insight into Nelf-mediated pol II pausing., [RefSeq, PubMed]; This gene encodes subunit B of a metazoan-specific, four-subunit protein complex that regulates promoter-proximal pausing of RNA polymerase II. RNA polymerase II pausing is thought to be important for coordination of gene transcription during embryonic development and stress responses. Consistently, disruption of this gene in mouse causes inner cell mass deficiency and embryonic lethality. In addition, this gene is required for maintenance of mouse embryonic stem cells by preventing expression of developmental genes. In adult mice, conditional deletion of this gene results in cardiomyopathy and impaired response to cardiac stress. Multiple protein isoforms are encoded through the use of a non-AUG (CUG) initiation codon and an alternative downstream AUG initiation codon. In addition, alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0X1KG62;Q69ZP4;Q99J41;Q9JJA5", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0140870 RNA polymerase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0008283 cell population proliferation;GO:0048863 stem cell differentiation;GO:0034244 negative regulation of transcription elongation by RNA polymerase II;GO:2000737 negative regulation of stem cell differentiation;GO:0160239 transcription pausing by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C4Y3-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGP6-1", "uniprot_id": "S2540_MOUSE", "mass": 37964.0, "length": 337, "protein_name": "Mitochondrial glutathione transporter SLC25A40", "gene_name": "Slc25a40", "organism": "Mouse", "refseq_name": "mitochondrial glutathione transporter SLC25A40 isoform a", "refseq_ac": "NP_001276524", "gene_names_uniprotkb": "Slc25a40", "gene_names_refseq": "B230315F11Rik; Slc25a40", "protein_names_uniprotkb": "Mitochondrial glutathione transporter SLC25A40; Solute carrier family 25 member 40", "protein_names_refseq": "mitochondrial glutathione transporter SLC25A40 isoform a; probable mitochondrial glutathione transporter SLC25A40", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:319653)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;34707288;37507081", "class_list": "", "function": "Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis., [UniProtKB, UniProtKB, UniProtKB]; Probable mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis (PubMed:34707288)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVZ5;Q8BXT8", "ec_number_list": "", "go_molecular_function": "GO:0034634 glutathione transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0048821 erythrocyte development;GO:1990542 mitochondrial transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BGP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DD19-1", "uniprot_id": "RASF7_MOUSE", "mass": 39247.0, "length": 359, "protein_name": "Ras association domain-containing protein 7", "gene_name": "Rassf7", "organism": "Mouse", "refseq_name": "ras association domain-containing protein 7", "refseq_ac": "NP_080162", "gene_names_uniprotkb": "Rassf7", "gene_names_refseq": "2400009B11Rik; Rassf7", "protein_names_uniprotkb": "Ras association domain-containing protein 7", "protein_names_refseq": "Ras association (RalGDS/AF-6) domain family 7; ras association domain-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:66985)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;31219806;34428180", "class_list": "", "function": "Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0034451 centriolar satellite;GO:0005813 centrosome", "go_biological_process": "GO:0007165 signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DD19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AGL3-1", "uniprot_id": "RYR3_MOUSE", "mass": 551328.0, "length": 4863, "protein_name": "Ryanodine receptor 3", "gene_name": "Ryr3", "organism": "Mouse", "refseq_name": "ryanodine receptor 3 isoform X3", "refseq_ac": "XP_017172194", "gene_names_uniprotkb": "Ryr3", "gene_names_refseq": "C230090H21; RYR-3; Ryr3", "protein_names_uniprotkb": "Ryanodine receptor 3; Brain ryanodine receptor-calcium release channel; Brain-type ryanodine receptor; RYR-3; RyR3; Type 3 ryanodine receptor", "protein_names_refseq": "ryanodine receptor 3 isoform X3", "tax_id": 10090, "disease": "congenital myopathy 20 (Disease Ontology:DOID:0081352); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); alcohol use disorder (Disease Ontology:DOID:1574); congenital myopathy 1A (Disease Ontology:DOID:3529); hepatocellular carcinoma (Disease Ontology:DOID:684); malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": " (mmu:20192); (R-MMU-2672351); (R-MMU-5578775)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11500519;11717163;17596299;19503748;20214899;21750661;25428506;34428180;7621815;7635066;7876312;8702664;9582272", "class_list": "", "function": "Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers with isoforms that contain the full complement of transmembrane segments and modulate their activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70184;P70185;Q3V1H0;Q4JFC4;Q60836;Q62175;Q62198;Q9QY91", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005509 calcium ion binding;GO:0015278 intracellularly gated calcium channel activity;GO:0005219 ryanodine-sensitive calcium-release channel activity", "go_cellular_component": "GO:0005790 smooth endoplasmic reticulum;GO:0016020 membrane;GO:0042383 sarcolemma;GO:0030018 Z disc;GO:0034704 calcium channel complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0071277 cellular response to calcium ion;GO:0006941 striated muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A2AGL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVC6-1", "uniprot_id": "SGK1_MOUSE", "mass": 48928.0, "length": 431, "protein_name": "Serine/threonine-protein kinase Sgk1", "gene_name": "Sgk1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Sgk1 isoform a", "refseq_ac": "NP_001155317", "gene_names_uniprotkb": "Sgk1; Sgk", "gene_names_refseq": "Sgk1; Sgk", "protein_names_uniprotkb": "Serine/threonine-protein kinase Sgk1; 2.7.11.1; Serum/glucocorticoid-regulated kinase 1", "protein_names_refseq": "serine/threonine-protein kinase Sgk1 isoform a; serine/threonine-protein kinase Sgk1; serum and glucocorticoid-dependent protein kinase", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); transient cerebral ischemia (Disease Ontology:DOID:224); granulosa cell tumor (Disease Ontology:DOID:2999); serous cystadenocarcinoma (Disease Ontology:DOID:3114); mucinous cystadenocarcinoma (Disease Ontology:DOID:3603)", "pathway": " (mmu:20393); (R-MMU-1257604); (R-MMU-2672351); (R-MMU-6804757); (R-MMU-9031628)", "pathway_count": 5, "publication_count": 36, "publication_id_list": "10358046;10751222;12488318;12684516;15774535;18250455;18299400;19224205;19756449;19965929;20173027;20484733;20525693;20568246;20735411;21147854;21385992;21750661;21757730;21865597;21952136;23991167;25428506;25428507;25605945;27502757;27802388;30084848;30779550;31219806;32139897;32901079;33649389;34428180;38749087;8647846", "class_list": "", "function": "Integrating analysis of mRNA expression profiles indicates Sgk1 as a key mediator in muscle-brain crosstalk during resistance exercise., [RefSeq, PubMed]; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This enzyme is activated by protein phosphorylation and degraded via the ubiquitination and proteasome pathway. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 12. [provided by RefSeq, Sep 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJN4;Q3UKD0;Q3UKF2;Q3V1V1;Q6NS85", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.3.2.27;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.3.2.26;2.3.2.36;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0015459 potassium channel regulator activity;GO:0048156 tau protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0008542 visual learning;GO:0030307 positive regulation of cell growth;GO:0032869 cellular response to insulin stimulus;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q9WVC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JZX3-1", "uniprot_id": "POC1A_MOUSE", "mass": 45125.0, "length": 405, "protein_name": "POC1 centriolar protein homolog A", "gene_name": "Poc1a", "organism": "Mouse", "refseq_name": "POC1 centriolar protein homolog A", "refseq_ac": "NP_081630", "gene_names_uniprotkb": "Poc1a; Wdr51a", "gene_names_refseq": "2510040D07Rik; Poc1a; Wdr51a; cha", "protein_names_uniprotkb": "POC1 centriolar protein homolog A; WD repeat-containing protein 51A", "protein_names_refseq": "POC1 centriolar protein homolog A; WD repeat domain 51A; WD repeat-containing protein 51A", "tax_id": 10090, "disease": "", "pathway": " (mmu:70235)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22840364;26496357;31219806", "class_list": "", "function": "Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation (By similarity)., [UniProtKB]; Spermatogonial stem cell transplantation studies revealed that Poc1a is essential for normal function of both Sertoli cells and germ cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CY09", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007283 spermatogenesis;GO:0060271 cilium assembly;GO:0060348 bone development;GO:1905515 non-motile cilium assembly;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8JZX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2B3-1", "uniprot_id": "RGR_MOUSE", "mass": 32127.0, "length": 291, "protein_name": "RPE-retinal G protein-coupled receptor", "gene_name": "Rgr", "organism": "Mouse", "refseq_name": "RPE-retinal G protein-coupled receptor isoform 1", "refseq_ac": "NP_067315", "gene_names_uniprotkb": "Rgr", "gene_names_refseq": "Rgr", "protein_names_uniprotkb": "RPE-retinal G protein-coupled receptor; RGR opsin", "protein_names_refseq": "RGR opsin; RPE-retinal G protein-coupled receptor isoform 1; RPE-retinal G protein-coupled receptor", "tax_id": 10090, "disease": "retinitis pigmentosa 44 (Disease Ontology:DOID:0110394); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:57811); (R-MMU-418594); (R-MMU-419771)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11431696;12663652;12716426;15961402;18474598;21750661;31056353;34022179;37883094;9841934", "class_list": "", "function": "Human RGR Gene and Associated Features of Age-Related Macular Degeneration in Models of Retina-Choriocapillaris Atrophy., [RefSeq, PubMed]; Non-visual opsin that functions as a light-dependent facilitator of retinoid isomerization and trafficking in retinal pigment epithelium (RPE) and Mueller glia (PubMed:11431696). Participates in a photic visual cycle by complementing the classical enzymatic RPE65/RDH pathway for chromophore regeneration (PubMed:11431696, PubMed:12716426). Binds all-trans-retinal via a conserved Schiff-base lysine and, upon illumination, promotes photoisomerization of all-trans-retinal to 11-cis-retinal required for regeneration of visual pigments (PubMed:11431696, PubMed:15961402). Also mediates light-dependent mobilization of stored all-trans-retinyl esters from lipid droplets to endoplasmic reticulum membranes, facilitating their processing into 11-cis-retinoids (PubMed:18474598). May also modulate isomerohydrolase activity independent of light (PubMed:15961402). Although RGR is structurally a GPCR-family opsin, there is no consistent evidence that RGR activates G proteins or initiates a canonical second-messenger signaling cascade (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Proteopathy Linked to Exon-Skipping Isoform of RGR-Opsin Contributes to the Pathogenesis of Age-Related Macular Degeneration., [RefSeq, PubMed]; RGR opsin and retinol dehydrogenase-10 (Rdh10) convert all-trans-retinol to 11-cis-retinol during exposure to visible light. Cones in Rgr-/- retinas lost sensitivity at a faster rate than cones in Rgr+/+ retinas. A similar effect was seen in Rgr+/+ retinas following treatment with the glial cell toxin, alpha-aminoadipic acid., [RefSeq, PubMed]; Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism., [UniProtKB, UniProtKB]; Structure of rhodopsin and opsin dimer in native membranes, [RefSeq, PubMed]; The gene is a member of the opsin family of G-protein coupled receptors. The encoded protein is expressed in the retina, and acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Disruption of a similar gene in human is associated with autosomal recessive (arRP) and autosomal dominant retinitis pigmentosa (adRP). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016918 retinal binding;GO:0008020 G protein-coupled photoreceptor activity;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z2B3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08547-1", "uniprot_id": "SC22B_MOUSE", "mass": 24741.0, "length": 215, "protein_name": "Vesicle-trafficking protein SEC22b", "gene_name": "Sec22b", "organism": "Mouse", "refseq_name": "vesicle-trafficking protein SEC22b", "refseq_ac": "NP_035472", "gene_names_uniprotkb": "Sec22b; Sec22l1", "gene_names_refseq": "4930564D15Rik; ERS-24; Sec22b; Sec22l1", "protein_names_uniprotkb": "Vesicle-trafficking protein SEC22b; ER-Golgi SNARE of 24 kDa; ERS-24; ERS24; SEC22 vesicle-trafficking protein homolog B; SEC22 vesicle-trafficking protein-like 1; mSec22b", "protein_names_refseq": "ER-Golgi SNARE of 24 kDa; ERS24; SEC22 vesicle trafficking protein homolog B; SEC22 vesicle trafficking protein-like 1; mSec22b; vesicle-trafficking protein SEC22b", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:20333)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11309394;17242355;18630941;19144319;21183079;21750661;22645316;26495903;34428180;34580108;36210013;36595686;37638825;9094723", "class_list": "", "function": "SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sec22b Regulates Inflammatory Responses by Controlling the Nuclear Translocation of NF-kappaB and the Secretion of Inflammatory Mediators., [RefSeq, PubMed]; Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation of PLGA Microsphere-Encapsulated Antigen and a Synthetic Long Peptide In Vitro., [RefSeq, PubMed]; Sec22b is a critical and nonredundant regulator of plasma cell maintenance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91VU3", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042470 melanosome;GO:0012507 ER to Golgi transport vesicle membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0016192 vesicle-mediated transport;GO:0045732 positive regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O08547-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22605-1", "uniprot_id": "RARB_MOUSE", "mass": 53331.0, "length": 482, "protein_name": "Retinoic acid receptor beta", "gene_name": "Rarb", "organism": "Mouse", "refseq_name": "retinoic acid receptor beta isoform beta3", "refseq_ac": "NP_001276689", "gene_names_uniprotkb": "Rarb; Nr1b2", "gene_names_refseq": "A830025K23; Hap; Nr1b2; Rarb", "protein_names_uniprotkb": "Retinoic acid receptor beta; Nuclear receptor subfamily 1 group B member 2; RAR-beta", "protein_names_refseq": "RAR-beta; nuclear receptor subfamily 1 group B member 2; retinoic acid receptor beta isoform beta3", "tax_id": 10090, "disease": "syndromic microphthalmia 12 (Disease Ontology:DOID:0111800); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); asbestos-related lung carcinoma (Disease Ontology:DOID:7596)", "pathway": " (mmu:218772); (R-MMU-383280); (R-MMU-5362517)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "1313565;15528208;1663808;1846599;19389355;21750661;2544807;31219806;8383767", "class_list": "", "function": "Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (PubMed:19389355)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11417;P22604", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0002068 glandular epithelial cell development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P22605-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922Q5-1", "uniprot_id": "S35B3_MOUSE", "mass": 40889.0, "length": 369, "protein_name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 2", "gene_name": "Slc35b3", "organism": "Mouse", "refseq_name": "adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1", "refseq_ac": "NP_001163901", "gene_names_uniprotkb": "Slc35b3", "gene_names_refseq": "4921526O06Rik; CGI-19; PABST2; PAPST2; Slc35b3", "protein_names_uniprotkb": "Adenosine 3'-phospho 5'-phosphosulfate transporter 2; Solute carrier family 35 member B3", "protein_names_refseq": "PAPS transporter 2; adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1; adenosine 3'-phospho 5'-phosphosulfate transporter 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:108652); (R-MMU-174362); (R-MMU-727802)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "20011239;21750661", "class_list": "glycogene", "function": "PAPST-dependent sulfation of heparan sulfate or chondroitin sulfate chains regulates the extrinsic signaling required for the maintenance and normal differentiation of mouse embryonic stem cells.[PAPST1, PAPST2] Publication Status: Online-Only, [RefSeq, PubMed]; Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane;GO:0005802 trans-Golgi network;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0046963 3'-phosphoadenosine 5'-phosphosulfate transport;GO:0006478 peptidyl-tyrosine sulfation;GO:1902558 5'-adenylyl sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q922Q5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12672-1", "uniprot_id": "RAPSN_MOUSE", "mass": 46393.0, "length": 412, "protein_name": "43 kDa receptor-associated protein of the synapse", "gene_name": "Rapsn", "organism": "Mouse", "refseq_name": "43 kDa receptor-associated protein of the synapse isoform a", "refseq_ac": "NP_033049", "gene_names_uniprotkb": "Rapsn", "gene_names_refseq": "43kDa; Nraps; Rapsn; Raps; rapsyn", "protein_names_uniprotkb": "43 kDa receptor-associated protein of the synapse; 43 kDa postsynaptic protein; Acetylcholine receptor-associated 43 kDa protein; RAPsyn", "protein_names_refseq": "43 kDa postsynaptic protein; 43 kDa receptor-associated protein of the synapse isoform a; 43 kDa receptor-associated protein of the synapse; 43kDa acetylcholine receptor-associated protein; acetylcholine receptor-associated 43 kDa protein; receptor-associated protein of the synapse, 43 kDa", "tax_id": 10090, "disease": "congenital myasthenic syndrome 11 (Disease Ontology:DOID:0110675); fetal akinesia deformation sequence syndrome 2 (Disease Ontology:DOID:0111378)", "pathway": " (mmu:19400)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;2737281;31549961;3170600;34033754", "class_list": "", "function": "Membraneless condensates by Rapsn phase separation as a platform for neuromuscular junction formation. Erratum:[Neuron. 2022 Jan 19;110(2):350. doi: 10.1016/j.neuron.2021.12.032. PMID: 35051365], [RefSeq, PubMed]; Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2M2N6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0033130 acetylcholine receptor binding;GO:0043495 protein-membrane adaptor activity;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007528 neuromuscular junction development;GO:0043525 positive regulation of neuron apoptotic process;GO:0071340 skeletal muscle acetylcholine-gated channel clustering;GO:1900075 positive regulation of neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P12672-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D868-1", "uniprot_id": "PPIH_MOUSE", "mass": 20464.0, "length": 188, "protein_name": "Peptidyl-prolyl cis-trans isomerase H", "gene_name": "Ppihl; Ppih", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase H isoform 1", "refseq_ac": "NP_001103599", "gene_names_uniprotkb": "Ppihl; Ppih; Ppih", "gene_names_refseq": "1100001J08Rik; 2010111B15Rik; 4833408F11Rik; CYP-20; CYPH; D4Wsu43e; Ppih", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase H; 5.2.1.8; PPIase H; Rotamase H", "protein_names_refseq": "PPIase H; cyclophilin H; peptidyl-prolyl cis-trans isomerase H isoform 1; peptidyl-prolyl cis-trans isomerase H; rotamase H", "tax_id": 10090, "disease": "", "pathway": " (mmu:66101); (R-MMU-72163)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "19224205;20173027;21750661;22872234;25428506;30084848;30779550;31219806;34203471;34428180", "class_list": "", "function": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQU7", "ec_number_list": "5.2.1.8;3.6.4.13;3.1.13.-;2.7.7.48;2.7.7.6;3.6.4.10;3.4.19.12;2.7.11.1;2.3.2.27", "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071001 U4/U6 snRNP;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006457 protein folding;GO:0045070 positive regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D868-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNF8-1", "uniprot_id": "RIMB1_MOUSE", "mass": 199929.0, "length": 1846, "protein_name": "Peripheral-type benzodiazepine receptor-associated protein 1", "gene_name": "Tspoap1", "organism": "Mouse", "refseq_name": "peripheral-type benzodiazepine receptor-associated protein 1", "refseq_ac": "NP_766037", "gene_names_uniprotkb": "Tspoap1; Bzrap1; Kiaa0612; Rbp1", "gene_names_refseq": "Bzrap1; D230016K05; PRAX-1; Tspoap1; mKIAA0612", "protein_names_uniprotkb": "Peripheral-type benzodiazepine receptor-associated protein 1; PBR-IP; PRAX-1; Peripheral benzodiazepine receptor-interacting protein; RIM-BP1; RIMS-binding protein 1; TSPO-associated protein 1", "protein_names_refseq": "PBR-IP; RIM-BP1; RIMS-binding protein 1; benzodiazapine receptor associated protein 1; benzodiazepine receptor associated protein 1; peripheral benzodiazepine receptor-associated protein 1; peripheral benzodiazepine receptor-interacting protein; peripheral-type benzodiazepine receptor-associated protein 1", "tax_id": 10090, "disease": "dystonia 22, juvenile-onset (Disease Ontology:DOID:0060966); dystonia 22, adult-onset (Disease Ontology:DOID:0060967)", "pathway": " (mmu:207777); (R-MMU-181429); (R-MMU-181430); (R-MMU-196108); (R-MMU-210500); (R-MMU-212676); (R-MMU-264642)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "21750661;30059200;31219806;33539324;9915832", "class_list": "", "function": "Biallelic variants in TSPOAP1, encoding the active-zone protein RIMBP1, cause autosomal recessive dystonia., [RefSeq, PubMed]; Required for synaptic transmission regulation. It probably controls the recruitment of voltage-gated calcium channels to the presynaptic membrane, and modulates neurotransmitter release., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5NCP7;Q80TV9;Q8BIH5", "ec_number_list": "", "go_molecular_function": "GO:0030156 benzodiazepine receptor binding;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046928 regulation of neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7TNF8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5U4E2-1", "uniprot_id": "REPI1_MOUSE", "mass": 61830.0, "length": 545, "protein_name": "DNA-binding protein REPIN1", "gene_name": "Repin1", "organism": "Mouse", "refseq_name": "DNA-binding protein REPIN1 isoform a", "refseq_ac": "NP_001073370", "gene_names_uniprotkb": "Repin1; Zfp464", "gene_names_refseq": "Ap4; E430037F08Rik; Repin1; Zfp-464; Zfp464", "protein_names_uniprotkb": "DNA-binding protein REPIN1; Zfp-464; Zinc finger protein 464", "protein_names_refseq": "DNA-binding protein REPIN1 isoform a; DNA-binding protein REPIN1; zinc finger protein 464 (RIP60)", "tax_id": 10090, "disease": "", "pathway": " (mmu:58887)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "20727851;21750661;23806337;24760138;27402271;28736440;30442920;30899593;37749079", "class_list": "", "function": "A potential role for Repin1 as regulator of adipocyte size was shown.Repin1 seems to be involved in the regulation of genes involved in adipogenesis., [RefSeq, PubMed]; Our findings indicate that Repin1 plays a role in insulin sensitivity and lipid metabolism by regulating key genes of glucose and lipid metabolism., [RefSeq, PubMed]; Our study provides evidence that loss of Repin1 in db/db mice improves insulin sensitivity and reduces chronic hyperglycemia most likely by reducing fat mass and AT inflammation., [RefSeq, PubMed]; REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis. Publication Status: Online-Only, [RefSeq, PubMed]; Repin1 might be of functional significance for early accumulation of lipids in hepatocytes after partial hepatectomy, facilitating efficient progression of liver regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Sequence-specific double-stranded DNA-binding protein. Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending (By similarity). May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation (PubMed:20727851, PubMed:24760138, PubMed:28736440, PubMed:30442920, PubMed:30899593). May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways (PubMed:24760138, PubMed:28736440, PubMed:37749079). May regulate the expression of genes involved in glucose transport (PubMed:20727851, PubMed:24760138)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTQ5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0046326 positive regulation of D-glucose import;GO:2000191 regulation of fatty acid transport;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5U4E2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921W4-1", "uniprot_id": "QORL1_MOUSE", "mass": 38725.0, "length": 348, "protein_name": "Ferry endosomal RAB5 effector complex subunit 4", "gene_name": "Cryzl1", "organism": "Mouse", "refseq_name": "ferry endosomal RAB5 effector complex subunit 4 isoform 1", "refseq_ac": "NP_598440", "gene_names_uniprotkb": "Cryzl1", "gene_names_refseq": "2210407J23Rik; 2410006O11Rik; Cryzl1; QOH-1", "protein_names_uniprotkb": "Ferry endosomal RAB5 effector complex subunit 4; Crystallin zeta like 1", "protein_names_refseq": "crystallin, zeta (quinone reductase)-like 1; ferry endosomal RAB5 effector complex subunit 4 isoform 1; ferry endosomal RAB5 effector complex subunit 4; quinone oxidoreductase homolog 1; quinone oxidoreductase-like protein 1; zeta-crystallin homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66609)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31599954;36210013", "class_list": "", "function": "Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKX2;Q8VCS1;Q9CWR9", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005769 early endosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q921W4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BXT1-1", "uniprot_id": "RGS8_MOUSE", "mass": 20963.0, "length": 180, "protein_name": "Regulator of G protein signaling 8", "gene_name": "Rgs8", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 8 isoform 1", "refseq_ac": "NP_080656", "gene_names_uniprotkb": "Rgs8", "gene_names_refseq": "6530413N01Rik; Rgs8", "protein_names_uniprotkb": "Regulator of G protein signaling 8; RGS8", "protein_names_refseq": "regulator of G-protein signaling 8 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67792); (R-MMU-418594)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "18762722;21750661;26755720;29758252", "class_list": "", "function": "RGS8 null mutant mice were viable, fertile and showed apparently normal development Publication Status: Online-Only, [RefSeq, PubMed]; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling., [UniProtKB, UniProtKB]; The crystal structure of RGS8 was determined in complex with Galphaq., [RefSeq, PubMed]; These findings suggest that RGS8 participates in modulation of depression-like behavior, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q505F2", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0045202 synapse;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0043547 positive regulation of GTPase activity;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0060159 regulation of dopamine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BXT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99K43-1", "uniprot_id": "PRC1_MOUSE", "mass": 70290.0, "length": 603, "protein_name": "Protein regulator of cytokinesis 1", "gene_name": "Prc1", "organism": "Mouse", "refseq_name": "protein regulator of cytokinesis 1 isoform 2", "refseq_ac": "NP_001272926", "gene_names_uniprotkb": "Prc1", "gene_names_refseq": "D7Ertd348e; Prc1", "protein_names_uniprotkb": "Protein regulator of cytokinesis 1", "protein_names_refseq": "protein regulator of cytokinesis 1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:233406); (R-MMU-5625900)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10727870;21750661;25428506;30084848;30779550;34428180;36635505", "class_list": "", "function": "Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression., [UniProtKB, UniProtKB]; Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPF0;Q8CE25", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0051301 cell division;GO:0000226 microtubule cytoskeleton organization;GO:0032465 regulation of cytokinesis;GO:0051256 mitotic spindle midzone assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99K43-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2H1-1", "uniprot_id": "PPHLN_MOUSE", "mass": 43835.0, "length": 381, "protein_name": "Periphilin-1", "gene_name": "Pphln1", "organism": "Mouse", "refseq_name": "periphilin-1 isoform 2", "refseq_ac": "NP_780572", "gene_names_uniprotkb": "Pphln1", "gene_names_refseq": "CR; HSPC206; HSPC232; Pphln1", "protein_names_uniprotkb": "Periphilin-1", "protein_names_refseq": "gastric cancer antigen Ga50; periphilin-1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:223828)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19144319;19621438;21183079;21750661;31219806;34428180;36210013", "class_list": "", "function": "RNA-binding component of the HUSH complex, a multiprotein complex that mediates epigenetic repression of mobile genetic elements, such as retroviruses and transposable elements (By similarity). The HUSH complex mainly represses LINE-1 (L1) retrotransposons that are still capable of transposition (By similarity). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2, a chromatin remodeler that compacts chromatin (By similarity). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (By similarity). Within the HUSH complex, PPHLN1 acts as a mRNA-binding component, which specifically binds nascent transcripts of mobile genetic elements, enabling HUSH-dependent silencing of transcripts (By similarity). Contributes to the maintenance of the HUSH complex at chromatin (By similarity). As part of the HUSH2 complex, promotes epigenetic repression of interferon-stimulated genes (By similarity). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (By similarity)., [UniProtKB, UniProtKB]; Results point to an indispensable function of periphilin during murine development and an important role in the nervous system, reflected by a strong and tightly regulated expression in the murine brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUZ6", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0031424 keratinization;GO:0045892 negative regulation of DNA-templated transcription;GO:0045814 negative regulation of gene expression, epigenetic;GO:0032480 negative regulation of type I interferon production", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K2H1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48026-1", "uniprot_id": "SAT1_MOUSE", "mass": 20012.0, "length": 171, "protein_name": "Diamine acetyltransferase 1", "gene_name": "Sat1", "organism": "Mouse", "refseq_name": "diamine acetyltransferase 1 isoform 1", "refseq_ac": "NP_033147", "gene_names_uniprotkb": "Sat1; Sat", "gene_names_refseq": "SSAT; Sat1; Sat", "protein_names_uniprotkb": "Diamine acetyltransferase 1; 2.3.1.57; Polyamine N-acetyltransferase 1; Putrescine acetyltransferase; SSAT-1; SSAT; Spermidine/spermine N(1)-acetyltransferase 1", "protein_names_refseq": "SSAT-1; diamine acetyltransferase 1 isoform 1; diamine acetyltransferase 1; polyamine N-acetyltransferase 1; putrescine acetyltransferase; spermidine/spermine N(1)-acetyltransferase 1", "tax_id": 10090, "disease": "anxiety disorder (Disease Ontology:DOID:2030); mood disorder (Disease Ontology:DOID:3324)", "pathway": " (mmu:20229); (R-MMU-351200)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18690703;21750661;35090880;35977808;8241266", "class_list": "", "function": "Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis., [RefSeq, PubMed]; Enzyme which catalyzes the acetylation of polyamines (PubMed:18690703). Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine (By similarity). This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines (By similarity). Also involved in the regulation of polyamine transport out of cells (By similarity). Also acts on 1,3-diaminopropane and 1,5-diaminopentane (By similarity)., [UniProtKB, PubMed, UniProtKB]; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Also acts on 1,3-diaminopropane and 1,5-diaminopentane., [UniProtKB, UniProtKB]; Loss-of-function variants in SAT1 cause X-linked childhood-onset systemic lupus erythematosus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U444", "ec_number_list": "2.3.1.57;2.3.1.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004145 diamine N-acetyltransferase activity;GO:0019809 spermidine binding;GO:0008080 N-acetyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0042127 regulation of cell population proliferation;GO:0006596 polyamine biosynthetic process;GO:0006598 polyamine catabolic process;GO:0009447 putrescine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P48026-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31651-1", "uniprot_id": "S6A12_MOUSE", "mass": 69614.0, "length": 614, "protein_name": "Sodium- and chloride-dependent betaine transporter", "gene_name": "Slc6a12", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Slc6a12; Bgt1; Gabt2; Gat-2; Gat2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium- and chloride-dependent betaine transporter; BGT-1; GAT-2; Na(+)/Cl(-) betaine/GABA transporter; Sodium- and chloride-dependent GABA transporter 2; Solute carrier family 6 member 12", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:14411); (R-MMU-352230); (R-MMU-71288); (R-MMU-888593)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1517200;21750661;22071246;30084848;34428180", "class_list": "", "function": "Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (By similarity). May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation (Probable). Probably also involved in renal and hepatic osmotic regulation (PubMed:22071246)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0042995 cell projection;GO:0016020 membrane", "go_biological_process": "GO:0031460 glycine betaine transport;GO:0006865 amino acid transport;GO:0009992 intracellular water homeostasis;GO:0035725 sodium ion transmembrane transport;GO:0015812 gamma-aminobutyric acid transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P31651-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVM1-1", "uniprot_id": "RGAP1_MOUSE", "mass": 70158.0, "length": 628, "protein_name": "Rac GTPase-activating protein 1", "gene_name": "Racgap1", "organism": "Mouse", "refseq_name": "rac GTPase-activating protein 1", "refseq_ac": "NP_001240737", "gene_names_uniprotkb": "Racgap1; Mgcracgap", "gene_names_refseq": "Band25; GTPase; MgcRacGAP; Racgap1; gtl11; mKIAA1478", "protein_names_uniprotkb": "Rac GTPase-activating protein 1; Male germ cell RacGap; MgcRacGAP", "protein_names_refseq": "male germ cell RacGap; rac GTPase-activating protein 1", "tax_id": 10090, "disease": "congenital dyserythropoietic anemia type IIIb (Disease Ontology:DOID:0051001)", "pathway": " (mmu:26934); (R-MMU-2132295); (R-MMU-6811434); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013423); (R-MMU-983189)", "pathway_count": 11, "publication_count": 14, "publication_id_list": "10235109;10493933;10979956;11287179;12590651;21183079;21750661;25428506;26495903;30084848;31219806;32423815;34428180;36852467", "class_list": "", "function": "Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Has a critical role in erythropoiesis (By similarity). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3THR5;Q3TI41;Q3TM81", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0051233 spindle midzone;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0007283 spermatogenesis;GO:0030218 erythrocyte differentiation;GO:0007266 Rho protein signal transduction;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9WVM1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UZ2-1", "uniprot_id": "SDA1_MOUSE", "mass": 79559.0, "length": 687, "protein_name": "Protein SDA1 homolog", "gene_name": "Sdad1", "organism": "Mouse", "refseq_name": "protein SDA1 homolog", "refseq_ac": "NP_766301", "gene_names_uniprotkb": "Sdad1", "gene_names_refseq": "4931421J16; Sdad1", "protein_names_uniprotkb": "Protein SDA1 homolog; SDA1 domain-containing protein 1", "protein_names_refseq": "SDA1 domain-containing protein 1; protein SDA1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:231452)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "17242355;19144319;21183079;21750661;22872234;29187734;30084848;30779550;31219806;34203471;34428180;35820727;40021952", "class_list": "", "function": "Required for 60S pre-ribosomal subunits export to the cytoplasm., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP91;Q3TUN3;Q8CDL7;Q99JQ4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0015031 protein transport;GO:0042273 ribosomal large subunit biogenesis;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q80UZ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JL61-1", "uniprot_id": "RFX5_MOUSE", "mass": 69735.0, "length": 658, "protein_name": "DNA-binding protein Rfx5", "gene_name": "Rfx5", "organism": "Mouse", "refseq_name": "DNA-binding protein Rfx5 isoform 1", "refseq_ac": "NP_059091", "gene_names_uniprotkb": "Rfx5", "gene_names_refseq": "Rfx5", "protein_names_uniprotkb": "DNA-binding protein Rfx5; Regulatory factor X 5", "protein_names_refseq": "DNA-binding protein Rfx5 isoform 1; DNA-binding protein Rfx5; regulatory factor X 5", "tax_id": 10090, "disease": "severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": " (mmu:53970)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10779326;21750661;25428506", "class_list": "", "function": "Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z1N0;G3X9S6;Q3U180", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0001221 transcription coregulator binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045348 positive regulation of MHC class II biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JL61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0E3-1", "uniprot_id": "SC5AB_MOUSE", "mass": 73798.0, "length": 673, "protein_name": "Sodium/myo-inositol cotransporter 2", "gene_name": "Slc5a11", "organism": "Mouse", "refseq_name": "sodium/myo-inositol cotransporter 2", "refseq_ac": "NP_666310", "gene_names_uniprotkb": "Slc5a11; Kst1; Smit2", "gene_names_refseq": "2010013B02Rik; Kst1; RKST2; SMIT2; Slc5a10; Slc5a11", "protein_names_uniprotkb": "Sodium/myo-inositol cotransporter 2; Na(+)/myo-inositol cotransporter 2; SMIT2; Sodium-dependent glucose cotransporter; Sodium/glucose cotransporter KST1; Sodium/myo-inositol transporter 2; Solute carrier family 5 member 11", "protein_names_refseq": "Na(+)/myo-inositol cotransporter 2; na+/myo-inositol cotransporter 2; sodium-coupled cotransporter KST1; sodium-dependent glucose cotransporter; sodium/glucose cotransporter KST1; sodium/myo-inositol cotransporter 2; sodium/myo-inositol transporter 2; solute carrier family 5 (sodium/glucose cotransporter), member 10; solute carrier family 5 member 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:233836); (R-MMU-429593)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12133831;21750661;21887366;22564531;34428180", "class_list": "", "function": "At low concentration, where SMIT1/2 activity gains importance, myo-inositol uptake is reduced by ammonia-induced intracellular acidification, [RefSeq, PubMed]; For SMIT2, at all three ages both cortical and cerebellar SMIT2 levels were significantly higher than hippocampal levels (p<0.05) and at 4 and 6 months of age, [RefSeq, PubMed]; Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Can also transport D-chiro-inositol (DCI) but not L-fucose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rabbit homologue acts as a low affinity Na/myo-inositol cotransporter., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6EZ51", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity;GO:0005365 myo-inositol transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0006814 sodium ion transport;GO:0015798 myo-inositol transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K0E3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35892-1", "uniprot_id": "SP100_MOUSE", "mass": 54727.0, "length": 482, "protein_name": "Nuclear autoantigen Sp-100", "gene_name": "Sp100", "organism": "Mouse", "refseq_name": "nuclear autoantigen Sp-100 isoform 2", "refseq_ac": "NP_001300641", "gene_names_uniprotkb": "Sp100", "gene_names_refseq": "A430075G10Rik; Sp100", "protein_names_uniprotkb": "Nuclear autoantigen Sp-100; Nuclear dot-associated Sp100 protein; Speckled 100 kDa", "protein_names_refseq": "nuclear autoantigen Sp-100 isoform 2; nuclear autoantigen Sp-100; nuclear dot-associated Sp100 protein; speckled 100 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:20684)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17242355;21183079;21750661;31180531;31219806;34428180;39627609;9268632;9678363", "class_list": "", "function": "Findings demonstrated that spheroids from pancreatic cancer cells caused circular defects in lymphatic endothelial monolayers. These CCIDs in pancreatic cancer were partly regulated by S100P., [RefSeq, PubMed]; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. May also play a role in infection by viruses through mechanisms that may involve chromatin and/or transcriptional regulation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PY02;O35897;O88392;O88395", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O35892-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UW3-1", "uniprot_id": "RINL_MOUSE", "mass": 62354.0, "length": 563, "protein_name": "Ras and Rab interactor-like protein", "gene_name": "Rinl", "organism": "Mouse", "refseq_name": "ras and Rab interactor-like protein", "refseq_ac": "NP_796132", "gene_names_uniprotkb": "Rinl", "gene_names_refseq": "5830482F20Rik; 9930116N10Rik; Rinl", "protein_names_uniprotkb": "Ras and Rab interactor-like protein", "protein_names_refseq": "ras and Rab interactor-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:320435); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21419809;21750661", "class_list": "", "function": "Data show that Rinl is closely associated with the cytoskeleton and thus contributes to the spatial control of Rab5a and Rab22 signaling at actin-positive compartments., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRU0;Q811H9;Q8BUR6;Q8C0J1", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0030139 endocytic vesicle;GO:0001726 ruffle", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80UW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BW41-1", "uniprot_id": "PMGT2_MOUSE", "mass": 66661.0, "length": 580, "protein_name": "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2", "gene_name": "Pomgnt2", "organism": "Mouse", "refseq_name": "protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2", "refseq_ac": "NP_001276487", "gene_names_uniprotkb": "Pomgnt2; Ago61; Eogtl; Gtdc2", "gene_names_refseq": "Ago61; Gtdc2; Pomgnt2", "protein_names_uniprotkb": "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; 2.4.1.312; Extracellular O-linked N-acetylglucosamine transferase-like; Glycosyltransferase-like domain-containing protein 2; POMGnT2", "protein_names_refseq": "glycosyltransferase-like domain containing 2; glycosyltransferase-like domain-containing protein 2; protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2", "tax_id": 10090, "disease": "congenital muscular dystrophy-dystroglycanopathy type A8 (Disease Ontology:DOID:0111231); muscular dystrophy-dystroglycanopathy type C8 (Disease Ontology:DOID:0112382)", "pathway": " (mmu:215494); (R-MMU-8932505)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22958903;24256719;30899004;33300544", "class_list": "glycogene;glycosyltransferase", "function": "AGO61-KO mice lacked laminin-binding glycans and exhibited phenotypes similar to those of known dystroglycanopathy mutants, as reflected by abnormalities in neural migration and basal lamina formation. Publication Status: Online-Only, [RefSeq, PubMed]; O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein (By similarity). Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:24256719)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 32, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q58F17;Q8BXZ9;Q8K0M5", "ec_number_list": "2.4.1.312", "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001764 neuron migration;GO:0006493 protein O-linked glycosylation;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 85, "hit_score": 1.9, "record_id": "Q8BW41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4VBF2-1", "uniprot_id": "R3HD4_MOUSE", "mass": 29660.0, "length": 262, "protein_name": "R3H domain-containing protein 4", "gene_name": "R3hdm4", "organism": "Mouse", "refseq_name": "R3H domain-containing protein 4 isoform 2", "refseq_ac": "NP_818775", "gene_names_uniprotkb": "R3hdm4", "gene_names_refseq": "C030046I01Rik; R3hdm4", "protein_names_uniprotkb": "R3H domain-containing protein 4", "protein_names_refseq": "R3H domain-containing protein 4 isoform 2; R3H domain-containing protein 4; R3H domain-containing protein C19orf22 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:109284)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJN1;Q8CGD7;Q8JZZ8", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4VBF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCH5-1", "uniprot_id": "RABEK_MOUSE", "mass": 41119.0, "length": 380, "protein_name": "Rab9 effector protein with kelch motifs", "gene_name": "Rabepk", "organism": "Mouse", "refseq_name": "rab9 effector protein with kelch motifs isoform 1", "refseq_ac": "NP_663497", "gene_names_uniprotkb": "Rabepk", "gene_names_refseq": "8430412M01Rik; 9530020D24Rik; Rab9p40; Rabepk", "protein_names_uniprotkb": "Rab9 effector protein with kelch motifs", "protein_names_refseq": "Rab9 effector p40; rab9 effector protein with kelch motifs isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:227746); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14530284;21750661;25428506;30779550", "class_list": "", "function": "Rab9 effector required for endosome to trans-Golgi network (TGN) transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZG7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0010008 endosome membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VCH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VID5-1", "uniprot_id": "RECQ5_MOUSE", "mass": 108246.0, "length": 982, "protein_name": "ATP-dependent DNA helicase Q5", "gene_name": "Recql5", "organism": "Mouse", "refseq_name": "ATP-dependent DNA helicase Q5", "refseq_ac": "NP_569721", "gene_names_uniprotkb": "Recql5", "gene_names_refseq": "RecQ5; Recq5b; Recql5b; Recql5", "protein_names_uniprotkb": "ATP-dependent DNA helicase Q5; 5.6.2.4; DNA 3'-5' helicase RecQ5; DNA helicase, RecQ-like type 5; RECQL5beta; RecQ protein-like 5; RecQ5", "protein_names_refseq": "ATP-dependent DNA helicase Q5; DNA 3'-5' helicase RecQ5; DNA helicase, RecQ-like type 5; RECQL5beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:170472)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11738818;18003859;18987339;20333788;21183079;21750661;26420964;29187734;31219806;34428180;38577877", "class_list": "", "function": "A Recql5 mutant facilitates complex CRISPR/Cas9-mediated chromosomal engineering in mouse zygotes., [RefSeq, PubMed]; DNA helicase that plays an important role in DNA replication, transcription and repair. Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability. Also associates with POLR1A and enforces the stability of ribosomal DNA arrays. Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress. Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination., [UniProtKB, UniProtKB]; Data suggest that Recql5 helps maintain active DNA replication to prevent collapse of replication forks and accumulation of DSBs, preserve genome integrity and prevent cell death after replication stress due to topoisomerase I poisoning., [RefSeq, PubMed]; Recql5 has a tumor suppressor role in the gastrointestinal tract of Apc(min) mice., [RefSeq, PubMed]; Recql5 protects the liver against LPS/D-Gal-induced injury by suppressing hepatocyte apoptosis and oxidative stress and modulation of CYP450 expression., [RefSeq, PubMed]; Recql5-deficient cells exhibit elevated frequencies of spontaneous DNA double-strand breaks and homologous recombination (, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQD7;Q8C7T6;Q8VID3", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0000278 mitotic cell cycle;GO:0006281 DNA repair;GO:0051301 cell division;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8VID5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8T3-1", "uniprot_id": "REBL1_MOUSE", "mass": 20934.0, "length": 184, "protein_name": "GTPase RhebL1", "gene_name": "Rhebl1", "organism": "Mouse", "refseq_name": "GTPase RhebL1", "refseq_ac": "NP_081243", "gene_names_uniprotkb": "Rhebl1", "gene_names_refseq": "1810036J22Rik; Rheb2; Rhebl1", "protein_names_uniprotkb": "GTPase RhebL1; 3.6.5.-; Ras homolog enriched in brain-like protein 1; Rheb-like protein 1", "protein_names_refseq": "GTPase RhebL1; ras homolog enriched in brain-like protein 1; rheb-like protein 1", "tax_id": 10090, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); tuberous sclerosis (Disease Ontology:DOID:13515); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:69159)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16328882;21750661;31219806", "class_list": "", "function": "Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0016020 membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0007264 small GTPase-mediated signal transduction;GO:0031929 TOR signaling;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D8T3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BL80-1", "uniprot_id": "RHG22_MOUSE", "mass": 77786.0, "length": 702, "protein_name": "Rho GTPase-activating protein 22", "gene_name": "Arhgap22", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 22 isoform 1", "refseq_ac": "NP_722495", "gene_names_uniprotkb": "Arhgap22", "gene_names_refseq": "Arhgap22; B230341L19Rik; RHOGAP2; p68RacGAP", "protein_names_uniprotkb": "Rho GTPase-activating protein 22; Rho-type GTPase-activating protein 22; p68RacGAP", "protein_names_refseq": "rho GTPase-activating protein 22 isoform 1; rho GTPase-activating protein 22; rho-type GTPase-activating protein 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:239027); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "14966113;21750661;32782141;34455539", "class_list": "", "function": "A multifunctional regulatory protein with Rac1-specific GTPase-activating activity; regulates transcriptional activity of the endothelin-1 promoter; involved in the signal transduction pathway regulating endothelial cell capillary tube formation, [RefSeq, PubMed]; Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice., [RefSeq, PubMed]; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6QHH6;Q8BVH4;Q8CHY5", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0030154 cell differentiation;GO:0051058 negative regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BL80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K072-1", "uniprot_id": "REEP4_MOUSE", "mass": 29691.0, "length": 257, "protein_name": "Receptor expression-enhancing protein 4", "gene_name": "Reep4", "organism": "Mouse", "refseq_name": "receptor expression-enhancing protein 4", "refseq_ac": "NP_850919", "gene_names_uniprotkb": "Reep4", "gene_names_refseq": "2700029E10Rik; Reep4", "protein_names_uniprotkb": "Receptor expression-enhancing protein 4", "protein_names_refseq": "receptor expression-enhancing protein 4", "tax_id": 10090, "disease": "hereditary spastic paraplegia 31 (Disease Ontology:DOID:0110782)", "pathway": " (mmu:72549)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15550249;19144319;21183079;21750661;25428506;30084848;31219806", "class_list": "", "function": "Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005881 cytoplasmic microtubule;GO:0071782 endoplasmic reticulum tubular network;GO:0005874 microtubule", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0051301 cell division;GO:0007084 mitotic nuclear membrane reassembly;GO:0006998 nuclear envelope organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K072-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4Q1-1", "uniprot_id": "RIBC2_MOUSE", "mass": 45244.0, "length": 377, "protein_name": "RIB43A-like with coiled-coils protein 2", "gene_name": "Ribc2", "organism": "Mouse", "refseq_name": "RIB43A-like with coiled-coils protein 2", "refseq_ac": "NP_080633", "gene_names_uniprotkb": "Ribc2", "gene_names_refseq": "4930579A10Rik; Ribc2; Trib", "protein_names_uniprotkb": "RIB43A-like with coiled-coils protein 2", "protein_names_refseq": "RIB43A-like with coiled-coils protein 2; testis-specific ribbon protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67747)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15563848;21750661;37295417;37865089;37989994", "class_list": "", "function": "Genomic structure and expression profile of mouse Trib and comparison of its homology with other ribbon proteins. GeneRIF: Trib expression is testis-specific and appears to be found only in the germ cells during the leptotene-pachytene stages of spermatogenesis., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X8W0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D4Q1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DPB4-1", "uniprot_id": "SCHI1_MOUSE", "mass": 53306.0, "length": 484, "protein_name": "Schwannomin-interacting protein 1", "gene_name": "Schip1", "organism": "Mouse", "refseq_name": "schwannomin-interacting protein 1 isoform b", "refseq_ac": "NP_001106891", "gene_names_uniprotkb": "Schip1", "gene_names_refseq": "Nf2ip; Schip-1; Schip1", "protein_names_uniprotkb": "Schwannomin-interacting protein 1; SCHIP-1", "protein_names_refseq": "neurofibromatosis 2 interacting protein; schwannomin-interacting protein 1 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:30953)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10669747;18550753;21750661;25950943;25953347;27979964", "class_list": "", "function": "A new and early role for SCHIP1 during axon development and establishment of the anterior commissure, is identified., [RefSeq, PubMed]; CK2-regulated IQJC-SCHIP-1 association with AnkG contributes to axon initial segment maintenance., [RefSeq, PubMed]; Work reveals that IQCJ-SCHIP1 interacts with several major nodal proteins, and we suggest that it contributes to a higher organizational level of the AnkG/betaIV-spectrin network critical for node integrity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8IJC6;A8IJD0;A8IJD3;F6YL02;F8WI70;Q3TI53;Q52KH1;Q6P9Y8;Q9CX07;Q9JLR0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0001822 kidney development;GO:0009791 post-embryonic development;GO:0048705 skeletal system morphogenesis;GO:0060021 roof of mouth development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0DPB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PHS6-1", "uniprot_id": "SNX13_MOUSE", "mass": 110819.0, "length": 957, "protein_name": "Sorting nexin-13", "gene_name": "Snx13", "organism": "Mouse", "refseq_name": "sorting nexin-13 isoform 1", "refseq_ac": "NP_001014973", "gene_names_uniprotkb": "Snx13", "gene_names_refseq": "Rgs-px1; Snx13; mKIAA0713", "protein_names_uniprotkb": "Sorting nexin-13", "protein_names_refseq": "sorting nexin-13 isoform 1", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 20 (Disease Ontology:DOID:0080066)", "pathway": " (mmu:217463)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;17077144;21750661", "class_list": "", "function": "May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis., [UniProtKB, PubMed]; Snx13-null embryos are defective in nutrient uptake and transport, which may contribute to the other developmental abnormalities observed., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0031901 early endosome membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043547 positive regulation of GTPase activity;GO:0009968 negative regulation of signal transduction;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PHS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923I7-1", "uniprot_id": "SC5A2_MOUSE", "mass": 73008.0, "length": 670, "protein_name": "Sodium/glucose cotransporter 2", "gene_name": "Slc5a2", "organism": "Mouse", "refseq_name": "sodium/glucose cotransporter 2", "refseq_ac": "NP_573517", "gene_names_uniprotkb": "Slc5a2; Sglt2", "gene_names_refseq": "Sglt2; Slc5a2", "protein_names_uniprotkb": "Sodium/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 2; Solute carrier family 5 member 2", "protein_names_refseq": "Na(+)/glucose cotransporter 2; low affinity sodium-dependent glucose cotransporter; sodium/glucose cotransporter 2", "tax_id": 10090, "disease": "familial renal glucosuria (Disease Ontology:DOID:0070613); hypertension (Disease Ontology:DOID:10763); renal glycosuria (Disease Ontology:DOID:9432)", "pathway": " (mmu:246787); (R-MMU-189200)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11749115;20616166;21357472;21750661;25428507;30084848;34203471;34428180;37047250;37277060;38278341;39145457", "class_list": "glycogene", "function": "Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1 (By similarity). Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (By similarity). Unlike SLC5A1/SGLT1, requires the auxiliary protein PDZK1IP1/MAP17 for full transporter activity (By similarity). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (PubMed:20616166)., [UniProtKB, UniProtKB, PubMed]; Increased expression of sodium-glucose cotransporter 2 and O-GlcNAcylation in hepatocytes drives non-alcoholic steatohepatitis., [RefSeq, PubMed]; Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Prevention of renal glucose reabsorption by SGLT2 deletion reduced hyperglycemia, improved glucose intolerance, and increased glucose-stimulated insulin secretion in vivo., [RefSeq, PubMed]; SGLT2 knockdown restores the Th17/Treg balance and suppresses diabetic nephropathy in db/db mice by regulating SGK1 via Na., [RefSeq, PubMed]; SGLT2 mediates glucose reabsorption in the early proximal tubule and most of the glucose reabsorption by the kidney, overall., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 48, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005412 D-glucose:sodium symporter activity;GO:0046872 metal ion binding;GO:0055056 D-glucose transmembrane transporter activity;GO:0015151 alpha-glucoside transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:1902495 transmembrane transporter complex;GO:0016020 membrane", "go_biological_process": "GO:0035623 renal D-glucose absorption;GO:1904659 D-glucose transmembrane transport;GO:0035811 negative regulation of urine volume;GO:0098719 sodium ion import across plasma membrane;GO:0036359 renal potassium excretion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q923I7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUP0-1", "uniprot_id": "RAMP2_MOUSE", "mass": 21017.0, "length": 189, "protein_name": "Receptor activity-modifying protein 2", "gene_name": "Ramp2", "organism": "Mouse", "refseq_name": "receptor activity-modifying protein 2 precursor", "refseq_ac": "NP_062317", "gene_names_uniprotkb": "Ramp2", "gene_names_refseq": "Ramp2", "protein_names_uniprotkb": "Receptor activity-modifying protein 2", "protein_names_refseq": "receptor activity-modifying protein 2 precursor; receptor activity-modifying protein 2", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); adult respiratory distress syndrome (Disease Ontology:DOID:11394); kidney disease (Disease Ontology:DOID:557); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:54409); (R-MMU-418555); (R-MMU-419812); (R-MMU-9856530)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10777702;10854696;11854283;21750661;33955458;38012983", "class_list": "", "function": "Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:10854696). Required for the transport of CALCRL to the plasma membrane (By similarity). Together with CALCRL, form a receptor complex for adrenomedullin/ADM (PubMed:10854696). Together with CALCR, act as a receptor complex for calcitonin/CT/CALC. Together with CALCR, also act as a receptor complex for amylin/IAPP (By similarity)., [UniProtKB, UniProtKB, PubMed]; Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane. Together with CALCRL, form a receptor complex for adrenomedullin/ADM. Together with CALCR, act as a receptor complex for calcitonin/CT/CALC. Together with CALCR, also act as a receptor complex for amylin/IAPP., [UniProtKB, UniProtKB]; Adrenomedullin Ameliorates Pulmonary Fibrosis by Regulating TGF-ss-Smads Signaling and Myofibroblast Differentiation., [RefSeq, PubMed]; Receptor activity-modifying proteins of adrenomedullin (RAMP2/3): Roles in the pathogenesis of ARDS., [RefSeq, PubMed]; Role in cell surface expression of CRLR/RAMP heterodimeric receptors, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6IS25", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0001605 adrenomedullin receptor activity;GO:1990409 adrenomedullin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:1903143 adrenomedullin receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0006886 intracellular protein transport;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WUP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TIT8-1", "uniprot_id": "SPX3_MOUSE", "mass": 54553.0, "length": 494, "protein_name": "Sugar phosphate exchanger 3", "gene_name": "Slc37a3", "organism": "Mouse", "refseq_name": "sugar phosphate exchanger 3 isoform a", "refseq_ac": "NP_082399", "gene_names_uniprotkb": "Slc37a3; Spx3", "gene_names_refseq": "2610507O21Rik; Slc37a3", "protein_names_uniprotkb": "Sugar phosphate exchanger 3; Solute carrier family 37 member 3", "protein_names_refseq": "solute carrier family 37 member 3; sugar phosphate exchanger 3 isoform a; sugar phosphate exchanger 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:72144)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;29745899", "class_list": "", "function": "Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity (By similarity). In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899)., [UniProtKB, UniProtKB, PubMed]; Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity. In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZD9;Q8BVX2", "ec_number_list": "", "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006855 xenobiotic transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TIT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQE3-1", "uniprot_id": "RT17_MOUSE", "mass": 13382.0, "length": 120, "protein_name": "Small ribosomal subunit protein uS17m", "gene_name": "Mrps17", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein uS17m precursor", "refseq_ac": "NP_079726", "gene_names_uniprotkb": "Mrps17; Rpms17", "gene_names_refseq": "1810006P02Rik; Mprs17; Mrps17", "protein_names_uniprotkb": "Small ribosomal subunit protein uS17m; 28S ribosomal protein S17, mitochondrial; MRP-S17; S17mt", "protein_names_refseq": "28S ribosomal protein S17, mitochondrial; MRP-S17; S17mt; small ribosomal subunit protein uS17m precursor; small ribosomal subunit protein uS17m", "tax_id": 10090, "disease": "", "pathway": " (mmu:66258); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11402041;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYK2-1", "uniprot_id": "QPCT_MOUSE", "mass": 41119.0, "length": 362, "protein_name": "Glutaminyl-peptide cyclotransferase", "gene_name": "Qpct", "organism": "Mouse", "refseq_name": "glutaminyl-peptide cyclotransferase isoform 2", "refseq_ac": "NP_001303658", "gene_names_uniprotkb": "Qpct", "gene_names_refseq": "5730422A13Rik; Qpct", "protein_names_uniprotkb": "Glutaminyl-peptide cyclotransferase; 2.3.2.5; Glutaminyl cyclase; Glutaminyl-tRNA cyclotransferase; QC", "protein_names_refseq": "QC; glutaminyl cyclase; glutaminyl-peptide cyclotransferase isoform 2; glutaminyl-tRNA cyclotransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:70536); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16201766;19699792;19804409;19809370;21671571;21750661;24886834;25446989;26447138;34428180", "class_list": "", "function": "Authors identified a placenta-specific imprinted gene Qpct. Results show that Qpct is widely expressed during early embryonic development and can be detected in the telencephalon, midbrain, and rhombencephalon at E9.5-E11.5., [RefSeq, PubMed]; Co-regulation of the enzyme glutaminyl cyclase and its substrate TRH was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta deposits, [RefSeq, PubMed]; Murine isoQC proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC., [RefSeq, PubMed]; QC is a zinc-dependent catalyst, [RefSeq, PubMed]; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue (By similarity)., [UniProtKB]; Results describe the expression of glutaminyl cyclase throughout the mouse brain during early postnatal development., [RefSeq, PubMed]; The observations of this study indicated that brain ischemia might be a pathogenic factor of alzheimer disease through increasing BACE1, cathepsin B, and glutaminyl cyclase., [RefSeq, PubMed]; This study provide a thorough comparative characterization of the glutaminyl cyclases QC and isoQC in defined brain regions of different inbred and outbred mouse strains, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH20;Q8VE07", "ec_number_list": "2.4.1.25;3.2.1.33;3.5.4.6;1.11.1.24;3.4.22.52;3.4.19.12;3.2.1.18;3.4.24.34;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.4.21.4;3.6.4.10;3.4.21.-;3.2.1.17;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;5.2.1.8;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;3.1.3.48;5.3.2.1;5.3.3.12;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;3.1.6.12;2.7.10.2;2.7.11.1;2.7.1.40;3.5.4.5;3.4.25.1;2.7.4.6;2.7.13.3;3.6.4.6;2.7.1.1;2.7.1.-;3.6.5.2;3.4.21.37;3.5.3.1;3.1.1.47;3.6.4.13;2.7.11.22;2.7.11.23;3.2.1.166;2.3.2.26;5.4.2.2;5.4.2.7;2.3.2.27;3.1.6.14;2.3.2.5;1.8.3.2;1.4.3.22;1.4.3.-;2.7.1.35;3.4.19.1;3.6.1.6;2.3.1.16;2.3.1.9;2.3.1.155;2.3.3.8;4.1.2.4;3.1.21.-;3.2.1.14;5.4.2.11;5.4.2.4;2.4.1.1;3.5.1.3;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-;3.4.19.9", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016603 glutaminyl-peptide cyclotransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CYK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D787-1", "uniprot_id": "PPIL2_MOUSE", "mass": 59065.0, "length": 521, "protein_name": "RING-type E3 ubiquitin-protein ligase PPIL2", "gene_name": "Ppil2", "organism": "Mouse", "refseq_name": "RING-type E3 ubiquitin-protein ligase PPIL2 isoform 1", "refseq_ac": "NP_001239373", "gene_names_uniprotkb": "Ppil2", "gene_names_refseq": "0610009L05Rik; 1700016N17Rik; 4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4; Ppil2", "protein_names_uniprotkb": "RING-type E3 ubiquitin-protein ligase PPIL2; 2.3.2.27; CYC4; PPIase; Probable inactive peptidyl-prolyl cis-trans isomerase-like 2", "protein_names_refseq": "PPIase; RING-type E3 ubiquitin transferase isomerase-like 2; RING-type E3 ubiquitin-protein ligase PPIL2 isoform 1; RING-type E3 ubiquitin-protein ligase PPIL2; cyclophilin-60; cyclophilin-like protein Cyp-60; peptidyl-prolyl cis-trans isomerase-like 2; probable inactive peptidyl-prolyl cis-trans isomerase-like 2; rotamase PPIL2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66053); (R-MMU-210991); (R-MMU-72163)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "15189447;21750661;22838834;25428506;34428180", "class_list": "", "function": "Cpsf2,Ppil2, and SNAP-25 are the most promising targets for the NSm protein of the virus during an infection. Publication Status: Online-Only, [RefSeq, PubMed]; Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q542A2;Q9CZL1", "ec_number_list": "3.6.4.13;5.2.1.8;3.1.13.-;2.7.7.48;2.7.7.6;3.6.4.10;2.3.2.27", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0072659 protein localization to plasma membrane;GO:0008380 RNA splicing;GO:0006457 protein folding;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D787-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55042-1", "uniprot_id": "SYUA_MOUSE", "mass": 14485.0, "length": 140, "protein_name": "Alpha-synuclein", "gene_name": "Snca", "organism": "Mouse", "refseq_name": "alpha-synuclein", "refseq_ac": "NP_001035916", "gene_names_uniprotkb": "Snca; Syn", "gene_names_refseq": "NACP; Snca; alpha-Syn; alphaSYN", "protein_names_uniprotkb": "Alpha-synuclein; NACP; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor", "protein_names_refseq": "alpha-synuclein; non-A beta component of AD amyloid; non-A4 component of amyloid", "tax_id": 10090, "disease": "Parkinson's disease 1 (Disease Ontology:DOID:0060367); Parkinson's disease 4 (Disease Ontology:DOID:0060895); Alzheimer's disease (Disease Ontology:DOID:10652); Pick's disease (Disease Ontology:DOID:11870); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); Lewy body dementia (Disease Ontology:DOID:12217); Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); neurilemmoma (Disease Ontology:DOID:3192); bipolar disorder (Disease Ontology:DOID:3312); pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981); multiple system atrophy (Disease Ontology:DOID:4752); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); myeloid leukemia (Disease Ontology:DOID:8692); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (mmu:20617); (R-MMU-9833482)", "pathway_count": 2, "publication_count": 80, "publication_id_list": "10707987;11156617;12732244;15304353;17296554;17908049;18343584;19004816;19272424;20798282;21562258;21849493;22517741;22645316;23209687;24192137;24252149;25008355;25037286;25112864;25246573;26192747;26205255;26495903;27003784;27012437;27143639;27358461;28068606;28569795;28599681;28619074;28623611;28657654;28924920;29184069;29888794;29950985;29988485;30059200;30333721;30798073;30927072;30932894;31034892;31092553;31110191;31205308;31437653;31796095;32192190;32210174;32372894;32391886;32393581;32502569;32706757;32716318;32848054;33088271;33138150;33401521;33421564;33428941;33776654;33895878;34194605;34678516;35250825;35327628;35357812;35822049;36266318;36450714;37507081;38347213;40021952;40885482;9601701;9648883", "class_list": "", "function": "Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282, PubMed:25246573). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3U130;Q9CXF8;Q9EQC3;Q9QUR3", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0000287 magnesium ion binding;GO:0003779 actin binding;GO:0004857 enzyme inhibitor activity;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006638 neutral lipid metabolic process;GO:0014048 regulation of glutamate secretion;GO:0050812 regulation of acyl-CoA biosynthetic process;GO:0051585 negative regulation of dopamine uptake involved in synaptic transmission;GO:0051622 negative regulation of norepinephrine uptake", "synthesized_glycan_count": 0, "hit_score": 9.3, "record_id": "O55042-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZW5-1", "uniprot_id": "TOM70_MOUSE", "mass": 67590.0, "length": 611, "protein_name": "Mitochondrial import receptor subunit TOM70", "gene_name": "Tomm70", "organism": "Mouse", "refseq_name": "mitochondrial import receptor subunit TOM70", "refseq_ac": "NP_613065", "gene_names_uniprotkb": "Tomm70; D16Wsu109e; Tomm70a", "gene_names_refseq": "2610044B22Rik; D16Ium22e; D16Ium22; D16Wsu109e; Tom70; Tomm70a; Tomm70; mKIAA0719", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM70; Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit; Translocase of outer mitochondrial membrane protein 70", "protein_names_refseq": "mitochondrial import receptor subunit TOM70; mitochondrial precursor proteins import receptor; translocase of outer membrane 70 kDa subunit; translocase of outer mitochondrial membrane 70 homolog A; translocase of outer mitochondrial membrane protein 70", "tax_id": 10090, "disease": "hypothyroidism (Disease Ontology:DOID:1459); congestive heart failure (Disease Ontology:DOID:6000); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:28185); (R-MMU-168928); (R-MMU-5205685); (R-MMU-5689880)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;16476741;17208939;18630941;19131326;19144319;20628368;21183079;22645316;25605945;33300544;34428180;35025629;36288343;38093274", "class_list": "", "function": "Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (By similarity). Mediates TBK1 and IRF3 activation induced by MAVS in response to virus infection and promotes host antiviral responses during virus infection (PubMed:20628368)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Mitochondria shed their outer membrane in response to infection-induced stress., [RefSeq, PubMed]; Tom70-regulated mitochondrial biogenesis via TFAM improves hypoxia-induced dysfunction of pulmonary vascular endothelial cells and alleviates hypoxic pulmonary hypertension. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNI6", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0097068 response to thyroxine;GO:0045039 protein insertion into mitochondrial inner membrane;GO:1903955 positive regulation of protein targeting to mitochondrion;GO:0006626 protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9CZW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D030-1", "uniprot_id": "TWST2_MOUSE", "mass": 18140.0, "length": 160, "protein_name": "Twist-related protein 2", "gene_name": "Twist2", "organism": "Mouse", "refseq_name": "twist-related protein 2", "refseq_ac": "NP_031881", "gene_names_uniprotkb": "Twist2; Dermo1", "gene_names_refseq": "Dermo1; Twist2; bHLHa39", "protein_names_uniprotkb": "Twist-related protein 2; Dermis-expressed protein 1; Dermo-1", "protein_names_refseq": "dermis-expressed protein 1; twist homolog 2; twist-related protein 2", "tax_id": 10090, "disease": "Barber-Say syndrome (Disease Ontology:DOID:0060549); ablepharon macrostomia syndrome (Disease Ontology:DOID:0060550); Saethre-Chotzen syndrome (Disease Ontology:DOID:14768)", "pathway": " (mmu:13345)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11809751;12553906;7589808", "class_list": "", "function": "Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors (By similarity)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D030-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70230-1", "uniprot_id": "ZN143_MOUSE", "mass": 69040.0, "length": 638, "protein_name": "Zinc finger protein 143", "gene_name": "Znf143", "organism": "Mouse", "refseq_name": "zinc finger protein 143 isoform 2", "refseq_ac": "NP_033307", "gene_names_uniprotkb": "Znf143; Staf; Zfp143", "gene_names_refseq": "D7Ertd805e; KRAB14; SBF; Staf; Zfp143; Zfp79; Zfp80-rs1; Znf143; pHZ-1", "protein_names_uniprotkb": "Zinc finger protein 143; Selenocysteine tRNA gene transcription-activating factor; Zfp-143; mStaf", "protein_names_refseq": "mStaf; selenocysteine tRNA gene transcription-activating factor; zfp-143; zinc finger protein 143 isoform 2; zinc finger protein 80, related sequence 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20841)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10657238;11528126;17092945;18687992;33397967;34428180;37566742;39708803;39708805;40997131;9535833", "class_list": "", "function": "Transcription factor that activates expression of genes transcribed by both RNA polymerases II and III, and which is required to safeguard mitochondrial activity (PubMed:39708805). Specifically recognizes and binds the Staf-binding site (SBS), a consensus DNA-binding motif present in thousands of promoters (PubMed:17092945). Activates the gene for selenocysteine tRNA (tRNAsec) (PubMed:9535833). Activates expression of small nuclear RNA (snRNA) transcribed by RNA polymerases II and III (By similarity). Also activates expression of mRNAs and acts as a key regulator of cell proliferation and differentiation by specifically activating expression of a subset of nuclear-encoded mitochondrial genes, thereby controlling mitochondrial function (PubMed:39708805). Involved in the maintenance of embryonic stem cells by promoting association of POU5F1/OCT4 to promoters, leading to NANOG expresion (PubMed:18687992)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway., [RefSeq, PubMed]; ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGB0;Q8CEI6;Q8CI27", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0001046 core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0031519 PcG protein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O70230-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLR1-1", "uniprot_id": "S61A2_MOUSE", "mass": 52248.0, "length": 476, "protein_name": "Protein transport protein Sec61 subunit alpha isoform 2", "gene_name": "Sec61a2", "organism": "Mouse", "refseq_name": "protein transport protein Sec61 subunit alpha isoform 2 isoform 1", "refseq_ac": "NP_067280", "gene_names_uniprotkb": "Sec61a2", "gene_names_refseq": "Sec61a2", "protein_names_uniprotkb": "Protein transport protein Sec61 subunit alpha isoform 2; Sec61 alpha-2", "protein_names_refseq": "Sec61 alpha; Sec61, alpha subunit 2; protein transport protein Sec61 subunit alpha isoform 2 isoform 1; protein transport protein Sec61 subunit alpha; sec61 alpha-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:57743)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005048 signal sequence binding;GO:0043022 ribosome binding;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005784 Sec61 translocon complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0031204 post-translational protein targeting to membrane, translocation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JLR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0Z9-1", "uniprot_id": "RHG07_MOUSE", "mass": 123367.0, "length": 1092, "protein_name": "Rho GTPase-activating protein 7", "gene_name": "Dlc1", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 7 isoform 3", "refseq_ac": "NP_001181870", "gene_names_uniprotkb": "Dlc1; Arhgap7; Stard12", "gene_names_refseq": "A730069N07Rik; Arhgap7; Dlc1; HP; STARD12; dlc-1", "protein_names_uniprotkb": "Rho GTPase-activating protein 7; DLC-1; Deleted in liver cancer 1 protein homolog; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StAR-related lipid transfer protein 12; StARD12", "protein_names_refseq": "START domain-containing protein 12; p122-RhoGAP; rho GTPase-activating protein 7 isoform 3; rho GTPase-activating protein 7; rho-type GTPase-activating protein 7; stAR-related lipid transfer protein 12", "tax_id": 10090, "disease": "gonadal dysgenesis (Disease Ontology:DOID:14447); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:50768); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013406)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10702663;12034501;15710412;17242355;18519636;20199662;21183079;21750661;22517741;28408355;29202196;30028837;34418053;34428180;36852467;40885482", "class_list": "", "function": "DLC-1 has a positive regulatory role in endothelial cell angiogenesis., [RefSeq, PubMed]; DLC-1-/- embryos had defects in the neural tube, brain, heart, and placenta, [RefSeq, PubMed]; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (By similarity). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (By similarity)., [UniProtKB, UniProtKB]; Low DLC1 expression is associated with Angiosarcoma., [RefSeq, PubMed]; Our data validate DLC1 as a potent tumor suppressor gene and suggest that its loss creates a dependence on the RhoA pathway that may be targeted therapeutically., [RefSeq, PubMed]; Talin unfolding determines DLC1 downstream signalling and, consequently, cell mechanics. Publication Status: Online-Only, [RefSeq, PubMed]; The Dlc1 deficient cells showed altered cytoskeleton structure, increased RhoA activity and cellular migration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRX3;Q3UH75;Q8R541", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008289 lipid binding;GO:0042169 SH2 domain binding;GO:0017166 vinculin binding;GO:0043274 phospholipase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005884 actin filament", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0030900 forebrain development;GO:0035556 intracellular signal transduction;GO:0030336 negative regulation of cell migration;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9R0Z9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14AI6-1", "uniprot_id": "RUSD3_MOUSE", "mass": 38076.0, "length": 344, "protein_name": "Mitochondrial mRNA pseudouridine synthase Rpusd3", "gene_name": "Rpusd3", "organism": "Mouse", "refseq_name": "mitochondrial mRNA pseudouridine synthase Rpusd3 isoform 1", "refseq_ac": "NP_001028376", "gene_names_uniprotkb": "Rpusd3", "gene_names_refseq": "Rpusd3", "protein_names_uniprotkb": "Mitochondrial mRNA pseudouridine synthase Rpusd3; 5.4.99.-; RNA pseudouridylate synthase domain-containing protein 3", "protein_names_refseq": "RNA pseudouridylate synthase domain-containing protein 3; mitochondrial mRNA pseudouridine synthase Rpusd3 isoform 1; mitochondrial mRNA pseudouridine synthase Rpusd3", "tax_id": 10090, "disease": "", "pathway": " (mmu:101122)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZF6;Q8BVS3;Q8CHZ5", "ec_number_list": "5.4.99.-;5.4.99.42;5.4.99.28;5.4.99.25;5.4.99.12", "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:1990481 mRNA pseudouridine synthesis;GO:0070131 positive regulation of mitochondrial translation;GO:0001522 pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q14AI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0D4-1", "uniprot_id": "RHG12_MOUSE", "mass": 95352.0, "length": 838, "protein_name": "Rho GTPase-activating protein 12", "gene_name": "Arhgap12", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 12 isoform 1", "refseq_ac": "NP_001034781", "gene_names_uniprotkb": "Arhgap12", "gene_names_refseq": "2810011M08Rik; Arhgap12", "protein_names_uniprotkb": "Rho GTPase-activating protein 12; Rho-type GTPase-activating protein 12", "protein_names_refseq": "rho GTPase-activating protein 12 isoform 1; rho GTPase-activating protein 12; rho-type GTPase-activating protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:75415); (R-MMU-9013149); (R-MMU-9013424); (R-MMU-9035034)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;15345747;17242355;17947660;18241859;18299400;18504429;20173027;21183079;21750661;21952136;25428506;30084848;30779550;33245966;34203471;34428180", "class_list": "", "function": "ARHGAP12 inactivates RAC1, thereby impairing cell motility, invasion and adhesion to the extracellular matrix. The gene is transcriptionally suppressed by Hepatocyte Growth Factor in human and murine cell lines., [RefSeq, PubMed]; Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity by sponging miR-135a-5p., [RefSeq, PubMed]; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Immunofluorescence staining and confocal laser-scanning microscopy demonstrated that Arhgap12 localizes at epithelial cell-cell adherent junctions in various mouse tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVP8", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0007015 actin filament organization;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0002011 morphogenesis of an epithelial sheet", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8C0D4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V9Z5-1", "uniprot_id": "SE6L2_MOUSE", "mass": 97504.0, "length": 910, "protein_name": "Seizure 6-like protein 2", "gene_name": "Sez6l2", "organism": "Mouse", "refseq_name": "seizure 6-like protein 2 isoform 2 precursor", "refseq_ac": "NP_001239495", "gene_names_uniprotkb": "Sez6l2", "gene_names_refseq": "BSRP-A; Psk1; Sez6l2", "protein_names_uniprotkb": "Seizure 6-like protein 2; BSRP-A; Brain-specific receptor-like protein A", "protein_names_refseq": "brain-specific receptor-like protein A; seizure 6-like protein 2 isoform 2 precursor; seizure 6-like protein 2; type I transmembrane receptor (seizure-related protein)", "tax_id": 10090, "disease": "", "pathway": " (mmu:233878)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16814779;19242545;21750661;25428506;29032200;33300544;34203471;35820727", "class_list": "", "function": "May contribute to specialized endoplasmic reticulum functions in neurons., [UniProtKB, PubMed]; Sez6l2 expression in mouse embryos was restricted to the spinal cord and brain, [RefSeq, PubMed]; Sez6l2 is one of the auxiliary subunits of the AMPA receptor and acts as a scaffolding protein to link GluR1 to ADD. Furthermore, Sez6l2 overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 modulates AMPA-ADD signal transduction., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q6AXF9;Q91X64", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:1990051 activation of protein kinase C activity;GO:0021680 cerebellar Purkinje cell layer development;GO:0060074 synapse maturation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q4V9Z5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C6U2-1", "uniprot_id": "S66A3_MOUSE", "mass": 22739.0, "length": 202, "protein_name": "Solute carrier family 66 member 3", "gene_name": "Slc66a3", "organism": "Mouse", "refseq_name": "solute carrier family 66 member 3 precursor", "refseq_ac": "NP_766162", "gene_names_uniprotkb": "Slc66a3; Pqlc3", "gene_names_refseq": "E030024M05Rik; Pqlc3; Slc66a3", "protein_names_uniprotkb": "Solute carrier family 66 member 3; PQ-loop repeat-containing protein 3", "protein_names_refseq": "PQ loop repeat containing 3; PQ-loop repeat-containing protein 3; solute carrier family 66 member 3 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:217430)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8QZS7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C6U2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35717-1", "uniprot_id": "SOCS2_MOUSE", "mass": 22434.0, "length": 198, "protein_name": "Suppressor of cytokine signaling 2", "gene_name": "Socs2", "organism": "Mouse", "refseq_name": "suppressor of cytokine signaling 2", "refseq_ac": "NP_001162126", "gene_names_uniprotkb": "Socs2", "gene_names_refseq": "8030460M17; CIS2; Cish2; D130043N08Rik; JAB; SOCS-2; SSI-2; Socs2; hg", "protein_names_uniprotkb": "Suppressor of cytokine signaling 2; SOCS-2", "protein_names_refseq": "CIS-2; STAT-induced STAT inhibitor 2; cytokine inducible SH2-containing protein 2; cytokine-inducible SH2 protein 2; suppressor of cytokine signaling 2", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); endometrial cancer (Disease Ontology:DOID:1380); invasive ductal carcinoma (Disease Ontology:DOID:3008); ovarian carcinoma (Disease Ontology:DOID:4001)", "pathway": " (mmu:216233); (R-MMU-8951664); (R-MMU-9706369)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10867663;10890450;12040024;15690087;21750661;31578312;38391249;39185412;9202125", "class_list": "", "function": "A loss of function mutation in SOCS2 results in increased inflammatory response of macrophages to TLR ligands and Staphylococcus aureus. Publication Status: Online-Only, [RefSeq, PubMed]; Mutation of SOCS2 induces structural and functional changes in mammary development., [RefSeq, PubMed]; Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR (By similarity). Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination (By similarity). The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2 (PubMed:10890450, PubMed:15690087). The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005159 insulin-like growth factor receptor binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0005131 growth hormone receptor binding;GO:0140031 phosphorylation-dependent protein binding;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031466 Cul5-RING ubiquitin ligase complex", "go_biological_process": "GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0040014 regulation of multicellular organism growth;GO:0045666 positive regulation of neuron differentiation;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35717-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQ62-1", "uniprot_id": "PODN_MOUSE", "mass": 68718.0, "length": 611, "protein_name": "Podocan", "gene_name": "Podn", "organism": "Mouse", "refseq_name": "podocan precursor", "refseq_ac": "NP_001272885", "gene_names_uniprotkb": "Podn", "gene_names_refseq": "9430070G18; Pcan; Podn; SLRR5A", "protein_names_uniprotkb": "Podocan", "protein_names_refseq": "podocan precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:242608)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12796502;15063725;21750661;34428180;38430223", "class_list": "", "function": "Negatively regulates cell proliferation and cell migration, especially in smooth muscle cells., [UniProtKB]; Podn was characterized in cultured mouse cells., [RefSeq, PubMed]; Podocan promoting skeletal muscle post-injury regeneration by inhibiting TGF-beta signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2A8F3;Q8BM45", "ec_number_list": "", "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TQ62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXE0-1", "uniprot_id": "PRDM5_MOUSE", "mass": 69550.0, "length": 599, "protein_name": "PR domain zinc finger protein 5", "gene_name": "Prdm5", "organism": "Mouse", "refseq_name": "PR domain zinc finger protein 5 isoform 1", "refseq_ac": "NP_081823", "gene_names_uniprotkb": "Prdm5", "gene_names_refseq": "4432417F03Rik; 6530401I24Rik; E130112L17Rik; PFM2; Prdm5", "protein_names_uniprotkb": "PR domain zinc finger protein 5; 2.1.1.-; PR domain-containing protein 5", "protein_names_refseq": "PR domain zinc finger protein 5 isoform 1; PR domain zinc finger protein 5; PR domain-containing protein 5", "tax_id": 10090, "disease": "brittle cornea syndrome 2 (Disease Ontology:DOID:0080729)", "pathway": " (mmu:70779)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;27485778;31219806;33235205;35820727", "class_list": "", "function": "Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice. Publication Status: Online-Only, [RefSeq, PubMed]; PRDM5 promotes the proliferation and invasion of murine melanoma cells through up-regulating JNK expression and strategies targeting PRDM5 may be promising for the therapy of melanoma., [RefSeq, PubMed]; Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes (By similarity). May regulate the expression of proteins involved in extracellular matrix development and maintenance, connective tissue components and molecules regulating cell migration and adhesion. May cause G2/M arrest and apoptosis in cancer cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSK8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CXE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZH4-1", "uniprot_id": "POGZ_MOUSE", "mass": 154910.0, "length": 1409, "protein_name": "Pogo transposable element with ZNF domain", "gene_name": "Pogz", "organism": "Mouse", "refseq_name": "pogo transposable element with ZNF domain isoform 1", "refseq_ac": "NP_766271", "gene_names_uniprotkb": "Pogz; Kiaa0461", "gene_names_refseq": "9530006B08Rik; Pogz", "protein_names_uniprotkb": "Pogo transposable element with ZNF domain", "protein_names_refseq": "pogo transposable element with ZNF domain isoform 1", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); White-Sutton syndrome (Disease Ontology:DOID:0070067); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:229584)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "21606357;21750661;22645316;25428506;28528544;29187734;29237092;32782141;32848054;34428180;34879283;35775424;35822049;36852467;37494184;38534384;39627609;40021952;40885482;40997131", "class_list": "", "function": "A convergent mechanism of high risk factors ADNP and POGZ in neurodevelopmental disorders., [RefSeq, PubMed]; Analyses of Conditional Knockout Mice for Pogz, a Gene Responsible for Neurodevelopmental Disorders in Excitatory and Inhibitory Neurons in the Brain. Publication Status: Online-Only, [RefSeq, PubMed]; Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes., [RefSeq, PubMed]; POGZ suppresses 2C transcriptional program and retrotransposable elements., [RefSeq, PubMed]; Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (By similarity). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 28, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 28, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 28, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 30, "binding_glycan_count": 0, "secondary_ac_list": "Q4VA94;Q80TZ8;Q8C0K1;Q8K294", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0051301 cell division;GO:0006355 regulation of DNA-templated transcription;GO:0000724 double-strand break repair via homologous recombination;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "Q8BZH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PCX7-1", "uniprot_id": "RGMA_MOUSE", "mass": 49676.0, "length": 454, "protein_name": "Repulsive guidance molecule A", "gene_name": "Rgma", "organism": "Mouse", "refseq_name": "repulsive guidance molecule A precursor", "refseq_ac": "NP_808408", "gene_names_uniprotkb": "Rgma", "gene_names_refseq": "C230063O06; Rgma", "protein_names_uniprotkb": "Repulsive guidance molecule A; RGM domain family member A", "protein_names_refseq": "RGM domain family, member A; repulsive guidance molecule A precursor; repulsive guidance molecule A", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); multiple sclerosis (Disease Ontology:DOID:2377); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:244058)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;14678836;14749425;15084667;15975920;17389603;17472960;17953666;18519029;21750661;25428506;34428180;36089003;37992159;38556067", "class_list": "", "function": "Knockdown of RGMA improves ischemic stroke via Reprogramming of Neuronal Metabolism., [RefSeq, PubMed]; Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Our data indicate an important role of RGMa for the layer-specific termination of the perforant pathway as a repulsive signal that compels entorhinal fibers to stay in their correct target zone, [RefSeq, PubMed]; Predominantly expressed in developing neuron., [RefSeq, PubMed]; RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS., [RefSeq, PubMed]; RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro. Erratum:[J Lipid Res. 2023 Feb;64(2):100331. doi: 10.1016/j.jlr.2023.100331. PMID: 36739768], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQ34;Q8CIH6", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:1990459 transferrin receptor binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0098552 side of membrane", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0010976 positive regulation of neuron projection development;GO:0031175 neuron projection development;GO:0043547 positive regulation of GTPase activity;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q6PCX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6ZQ82-1", "uniprot_id": "RHG26_MOUSE", "mass": 92071.0, "length": 814, "protein_name": "Rho GTPase-activating protein 26", "gene_name": "Arhgap26", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 26 isoform 1", "refseq_ac": "NP_780373", "gene_names_uniprotkb": "Arhgap26; Kiaa0621", "gene_names_refseq": "1810044B20Rik; 2610010G17Rik; 4933432P15Rik; Arhgap26; mKIAA0621", "protein_names_uniprotkb": "Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26", "protein_names_refseq": "rho GTPase-activating protein 26 isoform 1; rho GTPase-activating protein 26; rho-type GTPase-activating protein 26", "tax_id": 10090, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); Billuart-type X-linked syndromic intellectual developmental disorder (Disease Ontology:DOID:0080311); acute myelomonocytic leukemia (Disease Ontology:DOID:0081082)", "pathway": " (mmu:71302); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013404); (R-MMU-9013406); (R-MMU-9013409); (R-MMU-9013423)", "pathway_count": 10, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;21946561;30626696;34428180;36852467;38081847;38855880", "class_list": "", "function": "ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility., [RefSeq, PubMed]; GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; GTPase-activating protein for RHOA and CDC42 (By similarity). Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Study shows that brain Pyk2 interacts with the RhoGAP protein Graf1 to alter dendritic spine stability via RhoA GTPase. Amyloid-beta oligomer-induced dendritic spine loss requires the Pyk2/Graf1 pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QLL3", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005925 focal adhesion;GO:0010008 endosome membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6ZQ82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922G0-1", "uniprot_id": "S2536_MOUSE", "mass": 34170.0, "length": 311, "protein_name": "Solute carrier family 25 member 36", "gene_name": "Slc25a36", "organism": "Mouse", "refseq_name": "solute carrier family 25 member 36", "refseq_ac": "NP_620095", "gene_names_uniprotkb": "Slc25a36", "gene_names_refseq": "C330005L02Rik; Slc25a36", "protein_names_uniprotkb": "Solute carrier family 25 member 36", "protein_names_refseq": "solute carrier family 25 member 36", "tax_id": 10090, "disease": "familial hyperinsulinemic hypoglycemia 8 (Disease Ontology:DOID:0081328)", "pathway": " (mmu:192287)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31036718;31219806", "class_list": "", "function": "Cdx2-positive cells emerged in Slc25a36-deficient colonies under trophoblast stem cell culture conditions. As a result of Slc25a36 deficiency, mtDNA of knockdown cells declined, leading to impaired mitochondria with swollen morphology, decreased mitochondrial membrane potential, and low numbers. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports cytosine, guanosine, inosine and uridine (deoxy)nucleoside mono-, di-, and triphosphates by antiport mechanism. Catalyzes uniport at much lower rate (By similarity). May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside mono- and diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (By similarity). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015218 pyrimidine nucleotide transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0051881 regulation of mitochondrial membrane potential;GO:0007005 mitochondrion organization;GO:0006864 pyrimidine nucleotide transport;GO:1990519 pyrimidine nucleotide import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q922G0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2H1-1", "uniprot_id": "RGS11_MOUSE", "mass": 51075.0, "length": 443, "protein_name": "Regulator of G protein signaling 11", "gene_name": "Rgs11", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rgs11", "gene_names_refseq": "", "protein_names_uniprotkb": "Regulator of G protein signaling 11", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:50782); (R-MMU-418594); (R-MMU-6814122)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15632198;15897264;21750661", "class_list": "", "function": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCJ1", "ec_number_list": "", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0051286 cell tip;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043005 neuron projection", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0009968 negative regulation of signal transduction;GO:0008277 regulation of G protein-coupled receptor signaling pathway;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z2H1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUP4-1", "uniprot_id": "SR5A3_MOUSE", "mass": 37936.0, "length": 330, "protein_name": "Polyprenal reductase", "gene_name": "Srd5a3", "organism": "Mouse", "refseq_name": "polyprenal reductase", "refseq_ac": "NP_065636", "gene_names_uniprotkb": "Srd5a3; Srd5a2l", "gene_names_refseq": "1110025P14Rik; A430076C09; D730040M03Rik; H5ar; S5AR 3; Srd5a2l; Srd5a3", "protein_names_uniprotkb": "Polyprenal reductase; 1.3.1.22; 1.3.1.94; 3-oxo-5-alpha-steroid 4-dehydrogenase 3; S5AR 3; SR type 3; Steroid 5-alpha-reductase 2-like; Steroid 5-alpha-reductase 3", "protein_names_refseq": "3-oxo-5-alpha-steroid 4-dehydrogenase 3; H5AR gene; H5AR; SR type 3; polyprenal reductase; probable polyprenol reductase; steroid 5 alpha-reductase 2 like; steroid 5 alpha-reductase 2-like", "tax_id": 10090, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); Kahrizi syndrome (Disease Ontology:DOID:0050807); congenital disorder of glycosylation Iq (Disease Ontology:DOID:0080568)", "pathway": " (mmu:57357); (R-MMU-193048); (R-MMU-446199)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11116088;20637498;21750661;34428180;40885482", "class_list": "glycogene", "function": "Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT)., [UniProtKB, UniProtKB]; Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Srd5a3 mutation is lethal in mouse and results in an activation of the unfolded protein response pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3YZB6;D3Z3J5;Q3UU82;Q8BGE3", "ec_number_list": "1.3.1.22;1.3.1.94", "go_molecular_function": "GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity;GO:0160198 polyprenal reductase activity;GO:0102389 polyprenol reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0016095 polyprenol catabolic process;GO:0043048 dolichyl monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WUP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97858-1", "uniprot_id": "S35B1_MOUSE", "mass": 35883.0, "length": 322, "protein_name": "Solute carrier family 35 member B1", "gene_name": "Slc35b1", "organism": "Mouse", "refseq_name": "solute carrier family 35 member B1 isoform 2", "refseq_ac": "NP_001344726", "gene_names_uniprotkb": "Slc35b1; Ugalt2", "gene_names_refseq": "AXER; Slc35b1; UGTrel1; Ugalt2", "protein_names_uniprotkb": "Solute carrier family 35 member B1; ATP/ADP exchanger ER; AXER; Endoplasmic reticulum ATP/ADP translocase; UDP-galactose transporter-related protein 1; UGTrel1", "protein_names_refseq": "ATP/ADP exchanger ER; UDP-galactose translocator 2; UDP-galactose transporter-related protein 1; endoplasmic reticulum ATP/ADP translocase; solute carrier family 35 member B1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:110172)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;31219806;34203471;34428180;36210013;9010752", "class_list": "glycogene", "function": "ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane (By similarity). Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction (By similarity). Regulates ER energy metabolism and protein biogenesis (By similarity). Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply (By similarity). Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER (By similarity). Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CF70", "ec_number_list": "", "go_molecular_function": "GO:0005471 ATP:ADP antiporter activity;GO:0005459 UDP-galactose transmembrane transporter activity;GO:0005460 UDP-glucose transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072334 UDP-galactose transmembrane transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97858-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91ZS8-1", "uniprot_id": "RED1_MOUSE", "mass": 78001.0, "length": 711, "protein_name": "Double-stranded RNA-specific editase 1", "gene_name": "Adarb1", "organism": "Mouse", "refseq_name": "double-stranded RNA-specific editase 1 isoform 2", "refseq_ac": "NP_001020008", "gene_names_uniprotkb": "Adarb1; Adar2; Red1", "gene_names_refseq": "1700057H01Rik; Adar2; Adarb1; D10Bwg0447e; Red1", "protein_names_uniprotkb": "Double-stranded RNA-specific editase 1; 3.5.4.37; RNA-editing deaminase 1; RNA-editing enzyme 1; dsRNA adenosine deaminase", "protein_names_refseq": "RNA-editing deaminase 1; RNA-editing enzyme 1; double-stranded RNA-specific editase 1 isoform 2; double-stranded RNA-specific editase 1; dsRNA adenosine deaminase", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:110532); (R-MMU-75102); (R-MMU-77042)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12709013;16382140;17369310;19156214;20946981;21182352;21750661;33100268;35820727;38533529;38760406;38917633", "class_list": "", "function": "ADAR2 autoediting is a key regulator of ADAR2 protein expression and activity in vivo., [RefSeq, PubMed]; ADAR2 deficiency ameliorates non-alcoholic fatty liver disease and muscle atrophy through modulating serum amyloid A1., [RefSeq, PubMed]; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can inhibit cell proliferation and migration and can stimulate exocytosis., [UniProtKB, PubMed, PubMed]; Deficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in obese mice. Publication Status: Online-Only, [RefSeq, PubMed]; RNA editing enzyme ADAR2 regulates P-glycoprotein expression in murine breast cancer cells through the circRNA-miRNA pathway., [RefSeq, PubMed]; This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "C3TTQ1;Q3UHM7;Q8K3X1;Q91ZS6;Q91ZS7;Q91ZS9;Q99MU8", "ec_number_list": "3.5.4.37", "go_molecular_function": "GO:0003723 RNA binding;GO:0004000 adenosine deaminase activity;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060384 innervation;GO:0050685 positive regulation of mRNA processing;GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0007274 neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91ZS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NZN0-1", "uniprot_id": "RBM26_MOUSE", "mass": 114143.0, "length": 1012, "protein_name": "RNA-binding protein 26", "gene_name": "Rbm26", "organism": "Mouse", "refseq_name": "RNA-binding protein 26 isoform 4", "refseq_ac": "NP_598838", "gene_names_uniprotkb": "Rbm26", "gene_names_refseq": "1700009P03Rik; C230097K14Rik; MLZ-393; Pro1777; Rbm26; Se70-2", "protein_names_uniprotkb": "RNA-binding protein 26; MLZ-393; Protein expressed in male leptotene and zygotene spermatocytes 393; RNA-binding motif protein 26", "protein_names_refseq": "RNA-binding protein 26 isoform 4; RNA-binding protein 26; cutaneous T-cell lymphoma tumor antigen se70-2; protein expressed in male leptotene and zygotene spermatocytes 393", "tax_id": 10090, "disease": "", "pathway": " (mmu:74213); (R-MMU-9930044)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;20339383;21183079;21750661;23806337;29237092;32782141;32848054;34428180;35822049;36852467;39627609;40885482;40997131", "class_list": "", "function": "May be involved in the turnover of nuclear polyadenylated (pA+) RNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA77;Q3UTU9;Q8BQ22;Q8C7W9;Q8K101;Q921K4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q6NZN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLV9-1", "uniprot_id": "PR2C5_MOUSE", "mass": 25424.0, "length": 222, "protein_name": "Prolactin-2C5", "gene_name": "Prl2c5", "organism": "Mouse", "refseq_name": "prolactin-2C5 isoform 1 precursor", "refseq_ac": "NP_001298058", "gene_names_uniprotkb": "Prl2c5; Mrp4; Mrpplf4; Plf4", "gene_names_refseq": "Ghd3; MRP-4; Mrpplf4; PLF-4; Prl2c5", "protein_names_uniprotkb": "Prolactin-2C5; Mitogen-regulated protein 4", "protein_names_refseq": "growth hormone d3; mitogen regulated protein, proliferin 4; mitogen-regulated protein 4; prolactin-2C5 isoform 1 precursor; prolactin-2C5", "tax_id": 10090, "disease": "", "pathway": " (mmu:107849)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10537154;10803597;16876275;21750661;26697363", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKX5", "ec_number_list": "", "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JLV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1L5-1", "uniprot_id": "PP1RB_MOUSE", "mass": 14544.0, "length": 131, "protein_name": "E3 ubiquitin-protein ligase PPP1R11", "gene_name": "Ppp1r11", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase PPP1R11", "refseq_ac": "NP_083908", "gene_names_uniprotkb": "Ppp1r11; Tctex5", "gene_names_refseq": "1500041B02Rik; Hcgv; Ppp1r11; Tcte5; Tctex-5; Tctex5", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase PPP1R11; 2.3.2.27; Protein phosphatase 1 regulatory subunit 11; T-complex testis expressed protein 5; Tctex-5", "protein_names_refseq": "E3 ubiquitin-protein ligase PPP1R11; T-complex testis expressed protein 5; protein phosphatase 1 regulatory subunit 11; t-complex testis-expressed 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:76497)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1718647;19300506;21183079;21750661;27805901;30144392", "class_list": "", "function": "Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Data show a reciprocal relationship between protein phosphatase isoform PP1gamma2 and its regulator PPP1R11, and suggest that complex formation between them in testis may prevent proteolysis of PPP1R11 and germ cell apoptosis., [RefSeq, PubMed]; Lentiviral gene transfer or knockdown of PPP1R11 in mouse lungs significantly affects lung inflammation and the clearance of Staphylococcus aureus. There is a negative correlation between PPP1R11 and TLR2 levels in white blood cell samples isolated from patients with Staphylococcus aureus infections. Publication Status: Online-Only, [RefSeq, PubMed]; The three regulators (PPP1R2, PPP1R7, and PPP1R11)share localization with PP1gamma2 in the head and the principal piece of sperm. We show that the association of inhibitors to PP1gamma2 changes during epididymal sperm maturation. In immotile caput epididymal sperm, PPP1R2 and PPP1R7 are not bound to PP1gamma2, whereas in motile caudal sperm, all three inhibitors are bound as heterodimers or heterotrimers., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9DB02", "ec_number_list": "", "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0061630 ubiquitin protein ligase activity;GO:0008157 protein phosphatase 1 binding;GO:0004864 protein phosphatase inhibitor activity;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0001818 negative regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K1L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIA5-1", "uniprot_id": "S35B4_MOUSE", "mass": 37517.0, "length": 331, "protein_name": "Nucleotide sugar transporter SLC35B4", "gene_name": "Slc35b4", "organism": "Mouse", "refseq_name": "nucleotide sugar transporter SLC35B4", "refseq_ac": "NP_067410", "gene_names_uniprotkb": "Slc35b4; MNCb-4414", "gene_names_refseq": "4930474D06Rik; Slc35b4", "protein_names_uniprotkb": "Nucleotide sugar transporter SLC35B4; Solute carrier family 35 member B4; UDP-xylose and UDP-N-acetylglucosamine transporter", "protein_names_refseq": "UDP-xylose and UDP-N-acetylglucosamine transporter; nucleotide sugar transporter SLC35B4", "tax_id": 10090, "disease": "", "pathway": " (mmu:58246); (R-MMU-727802)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21507882;21750661;25428506;30084848;31599954;34428180", "class_list": "glycogene", "function": "Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for another nucleotide sugar. May couple UDP-alpha-D-glucuronate (UDP-GlcA) or UDP-alpha-D-xylose (UDP-Xyl) efflux to UDP-alpha-D-glucuronate (UDP-GlcA) influx into the ER lumen, which in turn stimulates glucuronidation and excretion of endobiotics and xenobiotics., [UniProtKB, UniProtKB]; Decreased SLC35B4 expression led to increased gluconeogenesis in H2.35 cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQU7;Q5U681;Q9JJF7", "ec_number_list": "", "go_molecular_function": "GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity;GO:0005464 UDP-xylose transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015790 UDP-xylose transmembrane transport;GO:0006111 regulation of gluconeogenesis;GO:1990569 UDP-N-acetylglucosamine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CIA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80SY5-1", "uniprot_id": "PR38B_MOUSE", "mass": 63753.0, "length": 542, "protein_name": "Pre-mRNA-splicing factor 38B", "gene_name": "Prpf38b", "organism": "Mouse", "refseq_name": "pre-mRNA-splicing factor 38B isoform 1", "refseq_ac": "NP_080121", "gene_names_uniprotkb": "Prpf38b", "gene_names_refseq": "1110021E09Rik; Prpf38b", "protein_names_uniprotkb": "Pre-mRNA-splicing factor 38B", "protein_names_refseq": "pre-mRNA-splicing factor 38B isoform 1; pre-mRNA-splicing factor 38B", "tax_id": 10090, "disease": "", "pathway": " (mmu:66921)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;21750661;23806337;25605945;31219806;34203471;34428180;36210013", "class_list": "", "function": "May be required for pre-mRNA splicing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTD9;Q9CU48;Q9CUI6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0071011 precatalytic spliceosome;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80SY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q67BT3-1", "uniprot_id": "S13A5_MOUSE", "mass": 63823.0, "length": 572, "protein_name": "Na(+)/citrate cotransporter", "gene_name": "Slc13a5", "organism": "Mouse", "refseq_name": "Na(+)/citrate cotransporter isoform 1", "refseq_ac": "NP_001004148", "gene_names_uniprotkb": "Slc13a5; Nact", "gene_names_refseq": "Indy; NaC2/NaCT; Nact; Slc13a5; mINDY", "protein_names_uniprotkb": "Na(+)/citrate cotransporter; NaCT; Sodium-coupled citrate transporter; Sodium-dependent citrate transporter; Solute carrier family 13 member 5", "protein_names_refseq": "Na(+)/citrate cotransporter isoform 1; Na(+)/citrate cotransporter; novel solute carrier family 13 (sodium-dependent dicarboxylate transporter) (Slc13a2 or 3) member; sodium-coupled citrate transporter; sodium-dependent citrate transporter; solute carrier family 13 member 5", "tax_id": 10090, "disease": "alcohol-related neurodevelopmental disorder (Disease Ontology:DOID:0050667); developmental and epileptic encephalopathy 25 (Disease Ontology:DOID:0080453); Kohlschutter-Tonz syndrome (Disease Ontology:DOID:0111668); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:237831); (R-MMU-9955298)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12826022;14656221;16516867;21750661;21803289;26324167;32682952;33491666;33544126;35448538", "class_list": "", "function": "Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood-brain barrier. Review article, [RefSeq, PubMed]; High-affinity sodium/citrate cotransporter that mediates citrate entry into cells, which is a critical participant of biochemical pathways (PubMed:14656221, PubMed:26324167, PubMed:35448538). May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis (PubMed:12826022). Transports citrate into the cell in a Na(+)-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form (PubMed:12826022, PubMed:14656221, PubMed:26324167). Can recognizes succinate as a substrate, but its affinity for succinate is several fold lower than for citrate (PubMed:14656221, PubMed:26324167). The stoichiometry is probably 4 Na(+) for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic (PubMed:14656221, PubMed:26324167). Involved in the regulation of citrate levels in the brain (PubMed:32682952)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Molecular cloning and transport properties of NaCT., [RefSeq, PubMed]; Na+ -coupled di/tricarboxylate transport system expressed in neurons as NaC2/NaCT, which can transport the tricarboxylate citrate as well as dicarboxylates such as succinate, alpha-ketoglutarate, and malate., [RefSeq, PubMed]; Our studies demonstrate a profound effect of mIndy on mammalian energy metabolism. Erratum:[Cell Metab. 2011 Oct 5;14(4):567], [RefSeq, PubMed]; The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0015137 citrate transmembrane transporter activity;GO:0017153 sodium:dicarboxylate symporter activity;GO:0005343 organic acid:sodium symporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015746 citrate transport;GO:0071285 cellular response to lithium ion;GO:0015742 alpha-ketoglutarate transport;GO:0015729 oxaloacetate transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q67BT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CE08-1", "uniprot_id": "PPAP_MOUSE", "mass": 43717.0, "length": 381, "protein_name": "Prostatic acid phosphatase", "gene_name": "Acp3", "organism": "Mouse", "refseq_name": "prostatic acid phosphatase isoform 2 precursor", "refseq_ac": "NP_062781", "gene_names_uniprotkb": "Acp3; Acpp", "gene_names_refseq": "5'-NT; A030005E02Rik; Acp3; Acpp; FRAP; Lap; PAP; Ppal", "protein_names_uniprotkb": "Prostatic acid phosphatase; 3.1.3.2; 3.1.3.48; 3.1.3.5; 5'-NT; 5'-nucleotidase; Acid phosphatase 3; Ecto-5'-nucleotidase; FRAP; Fluoride-resistant acid phosphatase; Protein tyrosine phosphatase ACP3; TMPase; Thiamine monophosphatase", "protein_names_refseq": "5'-nucleotidase; TMPase; acid phosphatase, prostate; ecto-5'-nucleotidase; fluoride-resistant acid phosphatase; lysosomal acid phosphatase; prostatic acid phosphatase isoform 2 precursor; prostatic acid phosphatase; protein tyrosine phosphatase ACP3; thiamine monophosphatase", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:56318); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;16024648;17638863;18940592;19158948;20084276;21750661;22086231;27306411;27348306;27783536;34428180", "class_list": "", "function": "A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity)., [UniProtKB, UniProtKB]; Functional PAP(thorn) neurons are essential for the analgesic effect, which is mediated by NGF-trkA signaling. Publication Status: Online-Only, [RefSeq, PubMed]; In addition to its tyrosine phosphatase activity, also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP. This extracellular adenosine leads to a decrease in chronic pain by activating A1R in nociceptive neurons., [UniProtKB, PubMed]; PAP has species-conserved antinociceptive effects and has pH-dependent ectonucleotidase activity, [RefSeq, PubMed]; PAP-immunoreactivity was present in type I and one of type III taste cells of taste buds. Thus, it is suggested that PAP might be a responsible ectoenzyme for metabolism of extracellular nucleotides, being involved in the regulation of taste signaling in taste buds. Publication Status: Online-Only, [RefSeq, PubMed]; These findings demonstrate that PAP secreted by PCa cells in OB bone metastases increases osteoprotegerin and plays a critical role in the vicious cross talk between cancer and bone cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A4QPG2;B8JJZ5;B8JJZ6;Q8C682;Q9QXH7", "ec_number_list": "3.1.3.48;3.1.3.5;3.1.3.89;3.1.3.99;3.1.3.2;3.1.3.1;3.1.3.67;3.1.3.-;3.1.3.16;3.9.1.1;2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;3.3.2.10;3.1.3.76;3.6.5.2;3.4.23.-;3.2.1.20;7.6.2.1;3.1.3.4;3.6.1.75;2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;3.1.3.91;2.7.1.77;7.6.2.-;3.1.3.106;3.1.3.35;3.1.3.27;3.4.16.2;3.1.3.21;3.1.3.18;3.2.1.25;2.5.1.18;3.5.1.92", "go_molecular_function": "GO:0033265 choline binding;GO:0052642 lysophosphatidic acid phosphatase activity;GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030141 secretory granule;GO:0045177 apical part of cell", "go_biological_process": "GO:0016311 dephosphorylation;GO:0006629 lipid metabolic process;GO:0009117 nucleotide metabolic process;GO:0046085 adenosine metabolic process;GO:0051930 regulation of sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CE08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5XK03-1", "uniprot_id": "SERC4_MOUSE", "mass": 53907.0, "length": 492, "protein_name": "Serine incorporator 4", "gene_name": "Serinc4", "organism": "Mouse", "refseq_name": "serine incorporator 4 isoform 1", "refseq_ac": "NP_001020542", "gene_names_uniprotkb": "Serinc4", "gene_names_refseq": "A930015D22Rik; Serinc4", "protein_names_uniprotkb": "Serine incorporator 4", "protein_names_refseq": "ortholog of serine incorporator 4 SERINC4; serine incorporator 4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:574418); (R-MMU-977347)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8U1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XK03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE96-1", "uniprot_id": "S35F6_MOUSE", "mass": 40978.0, "length": 372, "protein_name": "Solute carrier family 35 member F6", "gene_name": "Slc35f6", "organism": "Mouse", "refseq_name": "solute carrier family 35 member F6 precursor", "refseq_ac": "NP_783606", "gene_names_uniprotkb": "Slc35f6; 4930471M23Rik", "gene_names_refseq": "4930471M23Rik; 5730478O19Rik; ANT2BP; P40; Slc35f6; Tango9", "protein_names_uniprotkb": "Solute carrier family 35 member F6; ANT2-binding protein; ANT2BP; Transport and Golgi organization 9 homolog", "protein_names_refseq": "ANT2-binding protein; solute carrier family 35 member F6 precursor; transmembrane protein C2orf18 homolog; transport and Golgi organization 9 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:74919)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;30779550;34428180", "class_list": "", "function": "Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UB33;Q8BKN1;Q9D5B2", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VE96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWZ3-1", "uniprot_id": "RBM8A_MOUSE", "mass": 19889.0, "length": 174, "protein_name": "RNA-binding protein 8A", "gene_name": "Rbm8a", "organism": "Mouse", "refseq_name": "RNA-binding protein 8A isoform a", "refseq_ac": "NP_001095877", "gene_names_uniprotkb": "Rbm8a; Rbm8", "gene_names_refseq": "2310057C03Rik; Rbm8a; Rbm8", "protein_names_uniprotkb": "RNA-binding protein 8A; RNA-binding motif protein 8A; Ribonucleoprotein RBM8A", "protein_names_refseq": "RNA-binding motif protein 8A; RNA-binding protein 8A isoform a; RNA-binding protein 8A; ribonucleoprotein RBM8A", "tax_id": 10090, "disease": "thrombocytopenia-absent radius syndrome (Disease Ontology:DOID:14699)", "pathway": " (mmu:60365); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187); (R-MMU-975957)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "19144319;21183079;21750661;22872234;24416299;31219806;34203471;34428180;36105365;36902031;38534343", "class_list": "", "function": "Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs., [UniProtKB, UniProtKB, UniProtKB]; RBM8A Depletion Decreases the Cisplatin Resistance and Represses the Proliferation and Metastasis of Breast Cancer Cells via AKT/mTOR Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity)., [UniProtKB, UniProtKB]; The Exon Junction Complex Factor RBM8A in Glial Fibrillary Acid Protein-Expressing Astrocytes Modulates Locomotion Behaviors. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptomic Analyses of Brains of RBM8A Conditional Knockout Mice at Different Developmental Stages Reveal Conserved Signaling Pathways Contributing to Neurodevelopmental Diseases. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A023T672;Q3UT38;Q6GTD4;Q9D6U5", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation;GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CWZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH97-1", "uniprot_id": "RCN3_MOUSE", "mass": 38002.0, "length": 328, "protein_name": "Reticulocalbin-3", "gene_name": "Rcn3", "organism": "Mouse", "refseq_name": "reticulocalbin-3 precursor", "refseq_ac": "NP_080831", "gene_names_uniprotkb": "Rcn3; D7Ertd671e", "gene_names_refseq": "6030455P07Rik; D530026G20Rik; D7Ertd671e; RLP49; Rcn3", "protein_names_uniprotkb": "Reticulocalbin-3", "protein_names_refseq": "reticulocalbin-3 precursor; reticulocalbin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:52377)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;26252542;30899004;34203471;34428180;36288343", "class_list": "", "function": "Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:26252542). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (PubMed:26252542). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (PubMed:26252542). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (By similarity). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results indicate an essential role of Rcn3 in perinatal lung maturation and neonatal respiratory adaptation as well as shed additional light on the mechanism of neonatal respiratory distress syndrome development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q58E50;Q8R137;Q99K35;Q9CTD4", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0015031 protein transport;GO:0043129 surfactant homeostasis;GO:0055091 phospholipid homeostasis;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BH97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C4H2-1", "uniprot_id": "SAMD3_MOUSE", "mass": 60419.0, "length": 520, "protein_name": "Sterile alpha motif domain-containing protein 3", "gene_name": "Samd3", "organism": "Mouse", "refseq_name": "sterile alpha motif domain-containing protein 3 isoform 1", "refseq_ac": "NP_001013788", "gene_names_uniprotkb": "Samd3; Gm623", "gene_names_refseq": "Gm623; Samd3", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 3; SAM domain-containing protein 3", "protein_names_refseq": "SAM domain-containing protein 3; sterile alpha motif domain-containing protein 3 isoform 1; sterile alpha motif domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:268288)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;31219806;34428180;34626120;36210013", "class_list": "", "function": "A multifunctional mouse model to study the role of Samd3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QPH5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C4H2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Z22-1", "uniprot_id": "PORIM_MOUSE", "mass": 20178.0, "length": 195, "protein_name": "Porimin", "gene_name": "Tmem123", "organism": "Mouse", "refseq_name": "porimin precursor", "refseq_ac": "NP_598500", "gene_names_uniprotkb": "Tmem123", "gene_names_refseq": "2310075C12Rik; Tmem123", "protein_names_uniprotkb": "Porimin; Transmembrane protein 123", "protein_names_refseq": "porimin precursor; porimin; pro-oncosis receptor inducing membrane injury", "tax_id": 10090, "disease": "", "pathway": " (mmu:71929)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19144319;20685650;21183079;21750661;26495903;34428180;35820727", "class_list": "", "function": "Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability., [UniProtKB]; Tmem123 may be used as a new maturation marker in DCs and that this molecule may be closely associated with the cell surface expression of CD40., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9F6;Q3TLL2;Q3U1R6;Q8CEX4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91Z22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q640N3-1", "uniprot_id": "RHG30_MOUSE", "mass": 120114.0, "length": 1101, "protein_name": "Rho GTPase-activating protein 30", "gene_name": "Arhgap30", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 30", "refseq_ac": "NP_001005508", "gene_names_uniprotkb": "Arhgap30", "gene_names_refseq": "6030405P05Rik; Arhgap30; Gm102; mFLJ00267", "protein_names_uniprotkb": "Rho GTPase-activating protein 30; Rho-type GTPase-activating protein 30", "protein_names_refseq": "rho GTPase-activating protein 30; rho-type GTPase-activating protein 30", "tax_id": 10090, "disease": "", "pathway": " (mmu:226652); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149); (R-MMU-9013420)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "19144319;21183079;21750661;31219806;34428180;35820727;36084651;39627609", "class_list": "", "function": "GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QKX0;Q571I5", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0035024 negative regulation of Rho protein signal transduction;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q640N3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MK9-1", "uniprot_id": "RASF1_MOUSE", "mass": 38789.0, "length": 340, "protein_name": "Ras association domain-containing protein 1", "gene_name": "Rassf1", "organism": "Mouse", "refseq_name": "ras association domain-containing protein 1 isoform 1", "refseq_ac": "NP_001230677", "gene_names_uniprotkb": "Rassf1", "gene_names_refseq": "123F2; NORE2A; RDA32; REH3P21; Rassf1A; Rassf1B; Rassf1C; Rassf1", "protein_names_uniprotkb": "Ras association domain-containing protein 1; Protein 123F2", "protein_names_refseq": "123F protein; RASSF1A tumor suppressor; Ras association (RalGDS/AF-6) domain family 1; protein 123F2; ras association domain-containing protein 1 isoform 1; ras association domain-containing protein 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:56289)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11333291;15665283;17335777;21750661;23294242;30059200;31219806;34428180;34748271;34820594;36905106;38093706", "class_list": "", "function": "Deletion of this gene increases cancer susceptibility in mice., [RefSeq, PubMed]; Novel Circulating Hypermethylated RASSF1A ddPCR for Liquid Biopsies in Patients With Pediatric Solid Tumors. Publication Status: Online-Only, [RefSeq, PubMed]; Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage (By similarity)., [UniProtKB]; RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues., [RefSeq, PubMed]; RASSF1A promotes ATM signaling and RASSF1A methylation is a synthetic lethal marker for ATR inhibitors., [RefSeq, PubMed]; WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUF5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006974 DNA damage response;GO:0007265 Ras protein signal transduction;GO:0050821 protein stabilization;GO:0031398 positive regulation of protein ubiquitination;GO:1902806 regulation of cell cycle G1/S phase transition", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99MK9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88575-1", "uniprot_id": "S620B_MOUSE", "mass": 70687.0, "length": 635, "protein_name": "Sodium- and chloride-dependent transporter XTRP3B", "gene_name": "Slc6a20b", "organism": "Mouse", "refseq_name": "sodium- and chloride-dependent transporter XTRP3B isoform 1", "refseq_ac": "NP_035861", "gene_names_uniprotkb": "Slc6a20b; Slc6a20; Xt3; Xtrp3", "gene_names_refseq": "Sit1; Slc6a20b; Slc6a20; XT3; Xtrp3", "protein_names_uniprotkb": "Sodium- and chloride-dependent transporter XTRP3B; IMINO-K; Solute carrier family 6 member 20B", "protein_names_refseq": "IMINO-K; X transporter protein 3; sodium- and chloride-dependent transporter XTRP3B isoform 1; sodium- and chloride-dependent transporter XTRP3B; solute carrier family 6 (neurotransmitter transporter), member 20; solute carrier family 6, member 20B", "tax_id": 10090, "disease": "", "pathway": " (mmu:22599)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15632147;15689184;16174864;17167413;19657969;21750661;30084848;34428180;9932288", "class_list": "", "function": "Does not show transporter activity with a range of tested amino acids including proline, glutamine, glutamic acid, leucine, alanine, histidine, glycine and arginine., [UniProtKB, PubMed]; Molecular cloning of two mouse homologues corresponding to the single human SLC6A20 gene: these have been named XT3 and XT3s1, [RefSeq, PubMed]; Up-regulated in the kidneys of 3-day-old mice, accounting for the maturation of proline reabsorption in the mouse., [RefSeq, PubMed]; Using homology modeling we identified two highly conserved Na(+)-binding sites and a putative Cl(-)-binding site of SLC6A20., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QNK3;Q3TP52;Q91WT6", "ec_number_list": "", "go_molecular_function": "GO:0015193 L-proline transmembrane transporter activity;GO:0015199 amino-acid betaine transmembrane transporter activity;GO:0005298 proline:sodium symporter activity;GO:0015370 solute:sodium symporter activity;GO:0015171 amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0016020 membrane", "go_biological_process": "GO:0015816 glycine transport;GO:1905647 proline import across plasma membrane;GO:0015824 proline transport;GO:1904271 L-proline import across plasma membrane;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88575-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTY8-1", "uniprot_id": "SCFD2_MOUSE", "mass": 74751.0, "length": 684, "protein_name": "Sec1 family domain-containing protein 2", "gene_name": "Scfd2", "organism": "Mouse", "refseq_name": "sec1 family domain-containing protein 2 isoform a", "refseq_ac": "NP_001108132", "gene_names_uniprotkb": "Scfd2; Stxbp1l1", "gene_names_refseq": "E430013M20Rik; STXBP1L1; Scfd2", "protein_names_uniprotkb": "Sec1 family domain-containing protein 2; Neuronal Sec1; Syntaxin-binding protein 1-like 1", "protein_names_refseq": "neuronal Sec1; sec1 family domain-containing protein 2 isoform a; sec1 family domain-containing protein 2; syntaxin-binding protein 1-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:212986)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "May be involved in protein transport., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3USN5;Q8BFV9;Q8BKU5;Q8BKZ0;Q8BTP6;Q8BTQ9;Q8BXI1;Q8BXS0;Q8BZ58", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BTY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3L5-1", "uniprot_id": "SO3A1_MOUSE", "mass": 76763.0, "length": 710, "protein_name": "Solute carrier organic anion transporter family member 3A1", "gene_name": "Slco3a1", "organism": "Mouse", "refseq_name": "solute carrier organic anion transporter family member 3A1 isoform 2", "refseq_ac": "NP_001033732", "gene_names_uniprotkb": "Slco3a1; Oatp3a1; Oatpd; Slc21a11", "gene_names_refseq": "5830414C08Rik; Anr1; MJAM; OATP-D; Slc21a11; Slco3a1", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 3A1; MJAM; OATP-D; Organic anion-transporting polypeptide D; Sodium-independent organic anion transporter D; Solute carrier family 21 member 11", "protein_names_refseq": "androgen regulated protein 1; organic anion-transporting polypeptide D; sodium-independent organic anion transporter D; solute carrier family 21 (organic anion transporter), member 11; solute carrier organic anion transporter family member 3A1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:108116); (R-MMU-879518)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23643386;28011936;30063921;30084848;30779550;31599954;34428180;38473715", "class_list": "", "function": "Expression of St8sia2 and Slco3a1 was significantly altered in metabolically active tissues in Roux-en-Y gastric bypass-treated compared to weight-matched, sham-operated mice., [RefSeq, PubMed]; Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by Enhancing the Proliferation of Granulosa Cells in Mammals. Publication Status: Online-Only, [RefSeq, PubMed]; Putative organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormone L-thyroxine, prostanoids such as prostaglandin E1 and E2, bile acids such as taurocholate, glycolate and glycochenodeoxycholate and peptide hormones such as L-arginine vasopressin, likely operating in a tissue-specific manner (By similarity). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable).Mediates transport of tryptophan, phenyalanine, tyrosine and steroid hormone precursors dehydroepiandrosterone 3-sulfate and estrone 3-sulfate (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLX2;Q3U7W0;Q505P2;Q544H3;Q9CTV3;Q9JKV0", "ec_number_list": "6.2.1.3;6.2.1.-;6.2.1.15", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015132 prostaglandin transmembrane transporter activity;GO:0035673 oligopeptide transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0043410 positive regulation of MAPK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0015711 organic anion transport;GO:0015827 tryptophan transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8R3L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AUC7-1", "uniprot_id": "RHG36_MOUSE", "mass": 66600.0, "length": 590, "protein_name": "Rho GTPase-activating protein 36", "gene_name": "Arhgap36", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 36 isoform 1", "refseq_ac": "NP_001074592", "gene_names_uniprotkb": "Arhgap36", "gene_names_refseq": "1100001E04Rik; Arhgap36; rho-gap", "protein_names_uniprotkb": "Rho GTPase-activating protein 36", "protein_names_refseq": "RhoGAP domain containing protein; rho GTPase-activating protein 36 isoform 1; rho GTPase-activating protein 36", "tax_id": 10090, "disease": "long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (mmu:75404)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25024229;25428506;31305241", "class_list": "", "function": "A new mechanism of Gli transcription factor activation and implicate ARHGAP36 dysregulation in the onset and/or progression of GLI-dependent cancers. GeneRIF: Arhgap36 acts in a Smoothened-independent manner to promote the activation of full-length Gli proteins and induces the accumulation of Gli proteins in the primary cilium. Its ability to induce Gli-dependent transcription requires kinesin family member 3a and intraflagellar transport protein 88, proteins that are essential for ciliogenesis. Arhgap36 functionally and biochemically interacts with Suppressor of Fused., [RefSeq, PubMed]; AKT stimulates the Shh activity to induce lateral motor columnar motor neurons through the stabilization of ARHGAP36 proteins. Publication Status: Online-Only, [RefSeq, PubMed]; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D6Q0;A6H5U8;A8IP50;B1AUC6;B1AUC8", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0007224 smoothened signaling pathway;GO:1902533 positive regulation of intracellular signal transduction;GO:0021525 lateral motor column neuron differentiation;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B1AUC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZB1-1", "uniprot_id": "RGS20_MOUSE", "mass": 26986.0, "length": 239, "protein_name": "Regulator of G protein signaling 20", "gene_name": "Rgs20", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 20 isoform 3", "refseq_ac": "NP_001277301", "gene_names_uniprotkb": "Rgs20; Rgsz1", "gene_names_refseq": "2900073E09Rik; Rgs20; Rgsz1", "protein_names_uniprotkb": "Regulator of G protein signaling 20; RGS20; Regulator of G protein signaling Z1", "protein_names_refseq": "regulator of G-protein signaling 20 isoform 3; regulator of G-protein signaling Z1", "tax_id": 10090, "disease": "", "pathway": " (mmu:58175); (R-MMU-418594); (R-MMU-418597)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11882662;14997173;15827571;16900103;21750661;29440403;34203471;34428180;36310031", "class_list": "", "function": "A Regional and Projection-Specific Role of RGSz1 in the Ventrolateral Periaqueductal Grey in the Modulation of Morphine Reward., [RefSeq, PubMed]; Analysis of in vitro microtubule polymerization/depolymerization showed that binding of RGSZ1 to SCG10 effectively blocked the ability of SCG10 to induce microtubule disassembly, [RefSeq, PubMed]; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G protein. Negatively regulates mu-opioid receptor-mediated activation of the G proteins., [UniProtKB, PubMed, PubMed, PubMed]; RGSz1 function suppression optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/beta-catenin pathway, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14A97;Q3TY63;Q9CUV8;Q9QZB2", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0009898 cytoplasmic side of plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QZB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWL5-1", "uniprot_id": "RBMS3_MOUSE", "mass": 46927.0, "length": 431, "protein_name": "RNA-binding motif, single-stranded-interacting protein 3", "gene_name": "Rbms3", "organism": "Mouse", "refseq_name": "RNA-binding motif, single-stranded-interacting protein 3 isoform 4", "refseq_ac": "NP_001165592", "gene_names_uniprotkb": "Rbms3", "gene_names_refseq": "6720477E09Rik; 8430436O14Rik; Rbms3", "protein_names_uniprotkb": "RNA-binding motif, single-stranded-interacting protein 3", "protein_names_refseq": "RNA-binding motif, single-stranded-interacting protein 3 isoform 4; RNA-binding motif, single-stranded-interacting protein 3; RNA-binding protein RBMS3", "tax_id": 10090, "disease": "", "pathway": " (mmu:207181)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22372950;26495903;36112789", "class_list": "", "function": "Binding of Rbms3 to the 3'UTR of Ptf1a regulates the production of the Ptf1a protein, [RefSeq, PubMed]; Binds poly(A) and poly(U) oligoribonucleotides., [UniProtKB]; Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2VPR0;Q8BL73;Q8BLW6;Q8BMA7;Q8BMB5;Q8BML0;Q8BMN1", "ec_number_list": "", "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0045727 positive regulation of translation;GO:0002357 defense response to tumor cell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BWL5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15501-1", "uniprot_id": "SPBP_MOUSE", "mass": 21966.0, "length": 199, "protein_name": "Prostatic spermine-binding protein", "gene_name": "Sbp", "organism": "Mouse", "refseq_name": "prostatic spermine-binding protein precursor", "refseq_ac": "NP_035451", "gene_names_uniprotkb": "Sbp", "gene_names_refseq": "Sbp; p25", "protein_names_uniprotkb": "Prostatic spermine-binding protein; Major prostatic secretory glycoprotein; P25; SBP", "protein_names_refseq": "major prostatic secretory glycoprotein; prostatic spermine-binding protein precursor; prostatic spermine-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20234)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16337919;21750661;30084848;3502715", "class_list": "", "function": "Our data suggest a role for p25 in synaptic plasticity, synaptogenesis, learning, and memory and provide a model whereby deregulation of a plasticity factor can contribute to neurodegeneration., [RefSeq, PubMed]; This protein seems to be functional equivalent to rat prostatic spermine-binding protein, which is involved in polyamine binding., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0043394 proteoglycan binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016327 apicolateral plasma membrane", "go_biological_process": "GO:0016477 cell migration;GO:0045766 positive regulation of angiogenesis;GO:0042742 defense response to bacterium;GO:0043117 positive regulation of vascular permeability", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P15501-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3A4-1", "uniprot_id": "RHNO1_MOUSE", "mass": 26820.0, "length": 235, "protein_name": "RAD9, HUS1, RAD1-interacting nuclear orphan protein 1", "gene_name": "Rhno1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rhno1; 5930416I19Rik", "gene_names_refseq": "", "protein_names_uniprotkb": "RAD9, HUS1, RAD1-interacting nuclear orphan protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:72440); (R-MMU-5685938); (R-MMU-5693607); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis. MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair double-strand breaks in DNA that originate in S-phase. Accumulates in M-phase; following phosphorylation by PLK1, interacts with POLQ, enabling its recruitment to double-strand breaks for subsequent repair. Also involved in the DNA damage response (DDR) signaling in response to genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0N5;Q3UK55;Q99JS2", "ec_number_list": "", "go_molecular_function": "GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0035861 site of double-strand break;GO:0005694 chromosome", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0034644 cellular response to UV;GO:0071479 cellular response to ionizing radiation;GO:0000077 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K3A4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55128-1", "uniprot_id": "SAP18_MOUSE", "mass": 17595.0, "length": 153, "protein_name": "Histone deacetylase complex subunit SAP18", "gene_name": "Sap18b; Sap18", "organism": "Mouse", "refseq_name": "histone deacetylase complex subunit SAP18", "refseq_ac": "NP_033145", "gene_names_uniprotkb": "Sap18b; Sap18; Sap18", "gene_names_refseq": "C530046K05Rik; D11Ertd539e; EMegR4; Sap18a; Sap18; Sinbp1", "protein_names_uniprotkb": "Histone deacetylase complex subunit SAP18; 18 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p18", "protein_names_refseq": "18 kDa Sin3-associated polypeptide; Sin3-associated polypeptide 18; histone deacetylase complex subunit SAP18; sin3-associated polypeptide p18", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041953); (mmu:20220); (R-MMU-3214815); (R-MMU-72163)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "14611647;21750661;22388736;31395859;34428180;9511770", "class_list": "", "function": "CXCR2 deficiency increased SAP18 expression in tumor-bearing mice, which reduced STAT3 phosphorylation through restraining ERK1/2 activation. Our findings reveal a critical role for CXCR2 in regulating hematopoietic progenitor cell differentiation under tumor conditions, and SAP18 is a key negative regulator in this process. Erratum:[Cell Death Dis. 2019 Sep 5;10(9):641. doi: 10.1038/s41419-019-1869-6. PMID: 31488810] Publication Status: Online-Only, [RefSeq, PubMed]; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function (By similarity)., [UniProtKB, PubMed]; Suppressor of fused (Sufu) binds directly to SAP18., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q545L4", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0043065 positive regulation of apoptotic process;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O55128-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1EHW4-1", "uniprot_id": "SAP25_MOUSE", "mass": 19845.0, "length": 186, "protein_name": "Histone deacetylase complex subunit SAP25", "gene_name": "Sap25", "organism": "Mouse", "refseq_name": "histone deacetylase complex subunit SAP25 isoform 2", "refseq_ac": "NP_001075431", "gene_names_uniprotkb": "Sap25", "gene_names_refseq": "Sap25", "protein_names_uniprotkb": "Histone deacetylase complex subunit SAP25; 25 kDa Sin3-associated polypeptide; Sin3 corepressor complex subunit SAP25; mSin3A-binding protein", "protein_names_refseq": "25 kDa Sin3-associated polypeptide; histone deacetylase complex subunit SAP25 isoform 2; histone deacetylase complex subunit SAP25; mSin3A-binding protein; sin3 associated polypeptide; sin3 corepressor complex subunit SAP25; sin3A-binding protein, SAP25", "tax_id": 10090, "disease": "", "pathway": " (mmu:751865)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16449650;18089292;21750661;36852467", "class_list": "", "function": "Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q1EHW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BU91-1", "uniprot_id": "S26A9_MOUSE", "mass": 86852.0, "length": 790, "protein_name": "Solute carrier family 26 member 9", "gene_name": "Slc26a9", "organism": "Mouse", "refseq_name": "solute carrier family 26 member 9", "refseq_ac": "NP_796217", "gene_names_uniprotkb": "Slc26a9", "gene_names_refseq": "E030002L01Rik; Slc26a9", "protein_names_uniprotkb": "Solute carrier family 26 member 9; Anion transporter/exchanger protein 9", "protein_names_refseq": "SLC26A9 anion transporter/exchanger; anion transporter/exchanger protein 9; anion transporter/exchanger-9; solute carrier family 26 member 9", "tax_id": 10090, "disease": "gastrointestinal system disease (Disease Ontology:DOID:77)", "pathway": " (mmu:320718); (R-MMU-427601)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15800055;17120765;19004773;19365592;21750661;31339488;34428180;35426084", "class_list": "glycogene", "function": "Ion transporter that can act both as an ion channel and anion exchanger (PubMed:15800055, PubMed:17120765, PubMed:31339488). Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane (PubMed:31339488). Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15800055)., [UniProtKB, PubMed, PubMed, PubMed]; SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans., [RefSeq, PubMed]; Slc26a9 functions as an electrogenic nCl-/HCO3- exchanger, suggesting a role in pulmonary and gastric HCO3- secretion and/or CO2 transport., [RefSeq, PubMed]; Slc26a9 has three discrete physiological modes: nCl(-)-HCO(3)(-) exchanger, Cl(-) channel, and Na(+)-anion cotransporter., [RefSeq, PubMed]; Slc26a9 plays an essential role in gastric acid secretion via effects on the viability of tubulovesicles/secretory canaliculi and by regulating chloride secretion in parietal cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 47, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVC3", "ec_number_list": "5.6.1.6;1.8.-.-;1.8.5.1", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0005254 chloride channel activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0015106 bicarbonate transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0015701 bicarbonate transport;GO:0006820 monoatomic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BU91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQN9-1", "uniprot_id": "S19A2_MOUSE", "mass": 55676.0, "length": 498, "protein_name": "Thiamine transporter 1", "gene_name": "Slc19a2", "organism": "Mouse", "refseq_name": "thiamine transporter 1 isoform b", "refseq_ac": "NP_001263384", "gene_names_uniprotkb": "Slc19a2", "gene_names_refseq": "DDA1; Slc19a2; THTR1; TRMA; ThTr-1", "protein_names_uniprotkb": "Thiamine transporter 1; Solute carrier family 19 member 2; ThTr-1", "protein_names_refseq": "solute carrier family 19 member 2; thiamine transporter 1 isoform b; thiamine transporter 1", "tax_id": 10090, "disease": "biotin-responsive basal ganglia disease (Disease Ontology:DOID:0050659); thiamine-responsive megaloblastic anemia syndrome (Disease Ontology:DOID:0090117); megaloblastic anemia (Disease Ontology:DOID:13382); chronic kidney disease (Disease Ontology:DOID:784); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:116914); (R-MMU-196819)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11386850;11481326;11592824;12031504;12393806;14567973;14738878;16642288;21750661;22194418;24961373;34428180;35512554;35724964;39217145", "class_list": "", "function": "High-affinity transporter for the intake of thiamine (PubMed:11481326, PubMed:11592824, PubMed:12031504, PubMed:12393806, PubMed:22194418, PubMed:24961373, PubMed:35724964). Essential for spermatogenesis (PubMed:14567973, PubMed:14738878). Mediates H(+)-dependent pyridoxine transport (PubMed:35512554, PubMed:35724964)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRH5;Q8R4Y1", "ec_number_list": "", "go_molecular_function": "GO:0015234 thiamine transmembrane transporter activity;GO:0090482 vitamin transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0009229 thiamine diphosphate biosynthetic process;GO:0015888 thiamine transport;GO:0071934 thiamine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9EQN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZD5-1", "uniprot_id": "RAE2_MOUSE", "mass": 70010.0, "length": 621, "protein_name": "Rab proteins geranylgeranyltransferase component A 2", "gene_name": "Chml", "organism": "Mouse", "refseq_name": "rab proteins geranylgeranyltransferase component A 2", "refseq_ac": "NP_067325", "gene_names_uniprotkb": "Chml; Rep2", "gene_names_refseq": "Chml; E030003F13Rik; REP-2; Rep2", "protein_names_uniprotkb": "Rab proteins geranylgeranyltransferase component A 2; Choroideremia-like protein; REP-2; Rab escort protein 2", "protein_names_refseq": "choroideraemia-like protein; choroideremia-like protein; rab escort protein-2; rab proteins geranylgeranyltransferase component A 2", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841); choroideremia (Disease Ontology:DOID:9821)", "pathway": " (mmu:12663); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12242008;21750661;30084848;30779550;34428180", "class_list": "", "function": "Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VF88;Q8CH16", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0005092 GDP-dissociation inhibitor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005968 Rab-protein geranylgeranyltransferase complex;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006612 protein targeting to membrane;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport;GO:0018344 protein geranylgeranylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QZD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924H5-1", "uniprot_id": "RA51C_MOUSE", "mass": 40675.0, "length": 366, "protein_name": "DNA repair protein RAD51 homolog 3", "gene_name": "Rad51c", "organism": "Mouse", "refseq_name": "DNA repair protein RAD51 homolog 3 isoform 1", "refseq_ac": "NP_001278369", "gene_names_uniprotkb": "Rad51c; Rad51l2", "gene_names_refseq": "R51H3; Rad51c; Rad51l2", "protein_names_uniprotkb": "DNA repair protein RAD51 homolog 3; R51H3; RAD51 homolog C; RAD51-like protein 2", "protein_names_refseq": "DNA repair protein RAD51 homolog 3 isoform 1; DNA repair protein RAD51 homolog 3; RAD51 homolog C; RAD51-like protein 2", "tax_id": 10090, "disease": "Fanconi anemia complementation group O (Disease Ontology:DOID:0111096); Fanconi anemia (Disease Ontology:DOID:13636); hereditary breast ovarian cancer syndrome (Disease Ontology:DOID:5683)", "pathway": " (mmu:114714); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693616); (R-MMU-983231)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "11410366;17114795;17312021;19155299;20471405;21750661;24005329;25270124;26820992;31923208;36906610", "class_list": "", "function": "A critical synergy between Rad51c and Trp53 in tumour progression and provide a predictable in vivo model system for studying mechanisms of Rad51c-mediated carcinogenesis, [RefSeq, PubMed]; Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD51 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis., [UniProtKB, PubMed]; Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress. Erratum:[Nat Commun. 2024 Mar 12;15(1):2214. doi: 10.1038/s41467-024-46561-9. PMID: 38472265] Publication Status: Online-Only, [RefSeq, PubMed]; RAD51C has a late role in meiotic recombination., [RefSeq, PubMed]; Rad51c mutation in DH-cis mice promoted the development of tumors of specialized sebaceous glands and suppressed tumors characteristic of Trp53 mutation. In addition, DH-cis females developed tumors significantly earlier than any other group., [RefSeq, PubMed]; Similar to other BC models, Rad51c/p53 double-mutant mouse mammary tumors also reveal a propensity for genomic instability, but lack the focal amplification of the Met locus or distinct mutational signatures reported for other HR genes, [RefSeq, PubMed]; The RAD51C-XRCC3-associated Holliday junction resolvase complex associates with crossovers and may play an essential role in the resolution of recombination intermediates prior to chromosome segregation, [RefSeq, PubMed]; We demonstrate that miR-222 up-regulation, directly regulates Rad51c expression negatively, and impairs homologous recombination of double-strand break DNA repair during the initiation stage of cell transformation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KGK7;Q5SX32;Q8C653", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0000400 four-way junction DNA binding;GO:0008821 crossover junction DNA endonuclease activity;GO:0140664 ATP-dependent DNA damage sensor activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0033065 Rad51C-XRCC3 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000707 meiotic DNA recombinase assembly;GO:0007066 female meiosis sister chromatid cohesion;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q924H5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61818-1", "uniprot_id": "RAI1_MOUSE", "mass": 201571.0, "length": 1889, "protein_name": "Retinoic acid-induced protein 1", "gene_name": "Rai1", "organism": "Mouse", "refseq_name": "retinoic acid-induced protein 1", "refseq_ac": "NP_001032853", "gene_names_uniprotkb": "Rai1; Kiaa1820", "gene_names_refseq": "Gt1; Rai1", "protein_names_uniprotkb": "Retinoic acid-induced protein 1", "protein_names_refseq": "retinoic acid-induced protein 1", "tax_id": 10090, "disease": "Smith-Magenis syndrome (Disease Ontology:DOID:0060768); Potocki-Lupski syndrome (Disease Ontology:DOID:0060853)", "pathway": " (mmu:19377)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;15746153;21183079;21750661;22517741;22578325;25428506;28135057;30084848;31219806;32848054;34428180;34678516;36256819;37956053;38289192;40885482;40997131;7476016", "class_list": "", "function": "Comparative analyses of the Smith-Magenis syndrome protein RAI1 in mice and common marmoset monkeys., [RefSeq, PubMed]; Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome. Erratum:[Proc Natl Acad Sci U S A. 2022 Dec 27;119(52):e2219265119. doi: 10.1073/pnas.2219265119. PMID: 36534813], [RefSeq, PubMed]; Smith-Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulator of the circadian clock components: CLOCK, BMAL1, BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "B1AU87;Q6ZPH7;Q8CEV1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0001501 skeletal system development;GO:0045893 positive regulation of DNA-templated transcription;GO:0040015 negative regulation of multicellular organism growth;GO:0032922 circadian regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q61818-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YXK2-1", "uniprot_id": "SAFB1_MOUSE", "mass": 105104.0, "length": 937, "protein_name": "Scaffold attachment factor B1", "gene_name": "Safb", "organism": "Mouse", "refseq_name": "scaffold attachment factor B1 isoform 2", "refseq_ac": "NP_001156772", "gene_names_uniprotkb": "Safb; Safb1", "gene_names_refseq": "3110021E02Rik; 5330423C17Rik; E130307D12; HAP; HET; SAF-B1; SAFB1; Safb", "protein_names_uniprotkb": "Scaffold attachment factor B1; SAF-B1", "protein_names_refseq": "scaffold attachment factor B1 isoform 2; scaffold attachment factor B1", "tax_id": 10090, "disease": "", "pathway": " (mmu:224903); (R-MMU-3899300)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "11118435;15066997;15798188;17525332;19131326;19144319;19403048;21183079;21750661;24129315;25153642;25428506;25605945;28528544;30084848;30779550;34428180;34887587;37468167;38722021;39627609;40021952", "class_list": "", "function": "Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (By similarity). Thereby acts as a negative regulator of cell proliferation (By similarity). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (PubMed:19403048)., [UniProtKB, UniProtKB, PubMed]; SAFB associates with nascent RNAs and can promote gene expression in mouse embryonic stem cells., [RefSeq, PubMed]; SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA. Publication Status: Online-Only, [RefSeq, PubMed]; SAFB1 plays a critical role in development, growth regulation, and reproduction., [RefSeq, PubMed]; SAFB1 represses ERalpha activity via indirect association with histone deacetylation and interaction with the basal transcription machinery, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030496 midbody", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0040008 regulation of growth;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042445 hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "D3YXK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESD1-1", "uniprot_id": "PRSS8_MOUSE", "mass": 36729.0, "length": 342, "protein_name": "Prostasin", "gene_name": "Prss8", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Prss8; Cap1", "gene_names_refseq": "", "protein_names_uniprotkb": "Prostasin; 3.4.21.-; CAP1; Channel-activating protease 1; Serine protease 8", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal recessive congenital ichthyosis 4B (Disease Ontology:DOID:0060713); ovarian cancer (Disease Ontology:DOID:2394); breast carcinoma (Disease Ontology:DOID:3459); prostate carcinoma in situ (Disease Ontology:DOID:8634); alopecia (Disease Ontology:DOID:987)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10770960;21750661", "class_list": "", "function": "Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates (By similarity). Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017080 sodium channel regulator activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0016485 protein processing;GO:0010765 positive regulation of sodium ion transport;GO:1902307 positive regulation of sodium ion transmembrane transport;GO:0070633 transepithelial transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ESD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CH36-1", "uniprot_id": "S36A4_MOUSE", "mass": 55448.0, "length": 500, "protein_name": "Neutral amino acid uniporter 4", "gene_name": "Slc36a4", "organism": "Mouse", "refseq_name": "neutral amino acid uniporter 4 isoform 1", "refseq_ac": "NP_758493", "gene_names_uniprotkb": "Slc36a4; Pat4", "gene_names_refseq": "6330573I15Rik; PAT4; Slc36a4", "protein_names_uniprotkb": "Neutral amino acid uniporter 4; Solute carrier family 36 member 4", "protein_names_refseq": "neutral amino acid uniporter 4 isoform 1; neutral amino acid uniporter 4; proton-coupled amino acid transporter 4; proton/amino acid transporter 4; solute carrier family 36 member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:234967); (R-MMU-352230); (R-MMU-71240)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23478338;24530433;28083894", "class_list": "", "function": "A new mechanism of regulation of mTORC1 signalling and autophagy, that is, quality control of PAT4 by Rab12., [RefSeq, PubMed]; Detailed analysis of Slc36a4 mRNA distribution and protein mapping in mouse brain, showing an abundant expression in piriform cortex, hippocampus and hypothalamus in inhibitory and excitatory neurons and epithelial cells lining the ventricles in the brain, [RefSeq, PubMed]; The amino acid transporter SLC36A4/proton-dependent amino acid transporter (PAT4) regulates the amino acid pool in the lysosomes of retinal pigment epithelium., [RefSeq, PubMed]; Uniporter that mediates the transport of neutral amino acids like L-tryptophan, proline and alanine. The transport activity is sodium ions-independent, electroneutral and therefore functions via facilitated diffusion., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C077", "ec_number_list": "", "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0015193 L-proline transmembrane transporter activity;GO:0015196 L-tryptophan transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0005774 vacuolar membrane;GO:0016020 membrane", "go_biological_process": "GO:0015824 proline transport;GO:0015827 tryptophan transport;GO:0003333 amino acid transmembrane transport;GO:0015808 L-alanine transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CH36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QZX0-1", "uniprot_id": "SBK1_MOUSE", "mass": 45696.0, "length": 417, "protein_name": "Serine/threonine-protein kinase SBK1", "gene_name": "Sbk1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase SBK1", "refseq_ac": "NP_663562", "gene_names_uniprotkb": "Sbk1; Sbk", "gene_names_refseq": "Sbk1; Sbk", "protein_names_uniprotkb": "Serine/threonine-protein kinase SBK1; 2.7.11.1; SH3 domain-binding kinase 1", "protein_names_refseq": "SH3 domain-binding kinase 1; serine/threonine-protein kinase SBK1", "tax_id": 10090, "disease": "", "pathway": " (mmu:104175)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;35363898;37652166", "class_list": "", "function": "Differential regulation of hepatic SH3 domain binding kinase 1 (SBK1) expression in mouse and goldfish., [RefSeq, PubMed]; May be involved in signal-transduction pathways related to the control of brain development., [UniProtKB, UniProtKB, UniProtKB]; Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0018107 peptidyl-threonine phosphorylation;GO:0018105 peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8QZX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6I3-1", "uniprot_id": "PROF4_MOUSE", "mass": 14416.0, "length": 129, "protein_name": "Profilin-4", "gene_name": "Pfn4", "organism": "Mouse", "refseq_name": "profilin-4", "refseq_ac": "NP_082652", "gene_names_uniprotkb": "Pfn4", "gene_names_refseq": "2900024P18Rik; Pfn4", "protein_names_uniprotkb": "Profilin-4; Profilin IV", "protein_names_refseq": "profilin IV; profilin-4", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:382562)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15591451;21750661;35950913", "class_list": "", "function": "Involved in male fertility (PubMed:35950913). Required for manchette development and acrosome biogenesis during spermiogenesis (PubMed:35950913). Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Contrary to other profilin family members, does not bind to actin in vitro (By similarity)., [UniProtKB, UniProtKB, PubMed]; Involved in male fertility. Required for manchette development and acrosome biogenesis during spermiogenesis. Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Contrary to other profilin family members, does not bind to actin in vitro., [UniProtKB, UniProtKB]; PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6JEK6", "ec_number_list": "", "go_molecular_function": "GO:0003785 actin monomer binding;GO:0008289 lipid binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005938 cell cortex;GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0001675 acrosome assembly;GO:1905198 manchette assembly;GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D6I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97443-1", "uniprot_id": "SMYD1_MOUSE", "mass": 56496.0, "length": 490, "protein_name": "Histone-lysine N-methyltransferase Smyd1", "gene_name": "Smyd1", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase Smyd1 isoform 1", "refseq_ac": "NP_001153599", "gene_names_uniprotkb": "Smyd1; Bop", "gene_names_refseq": "4632404M21Rik; Bop; Smyd1; Zmynd18", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase Smyd1; 2.1.1.354; CD8b-opposite; SET and MYND domain-containing protein 1; Zinc finger protein BOP; m-BOP", "protein_names_refseq": "CD8b-opposite; CD8beta opposite strand; SET and MYND domain-containing protein 1; histone-lysine N-methyltransferase Smyd1 isoform 1; histone-lysine N-methyltransferase Smyd1; m-BOP; zinc finger protein BOP", "tax_id": 10090, "disease": "", "pathway": " (mmu:12180)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11923873;12011100;20943667;21750661;37212935;37507081;37923788;38042222;38440863;39927985;9013956", "class_list": "", "function": "Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis., [RefSeq, PubMed]; Methylates histone H3 at 'Lys-4' (H3K4me). Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis., [UniProtKB, PubMed, PubMed]; Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA. Publication Status: Online-Only, [RefSeq, PubMed]; Resistance training up-regulates Smyd1 expression and inhibits oxidative stress and endoplasmic reticulum stress in the heart of middle-aged mice., [RefSeq, PubMed]; SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation. Publication Status: Online-Only, [RefSeq, PubMed]; Similar kinetics of induction and localization of m-Bop and skNAC during the induction of myogenesis in cultured C2C12 cells suggests a possible associated role for these proteins during this process., [RefSeq, PubMed]; The histone methyltransferase SMYD1 is induced by thermogenic stimuli in adipose tissue., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97442;P97444;Q6DFW7", "ec_number_list": "2.1.1.354;2.1.1.-;2.1.1.359;2.1.1.355;2.1.1.362;2.1.1.361", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0042800 histone H3K4 methyltransferase activity;GO:0140999 histone H3K4 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P97443-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80UP8-1", "uniprot_id": "S20A2_MOUSE", "mass": 70866.0, "length": 656, "protein_name": "Sodium-dependent phosphate transporter 2", "gene_name": "Slc20a2", "organism": "Mouse", "refseq_name": "sodium-dependent phosphate transporter 2", "refseq_ac": "NP_035524", "gene_names_uniprotkb": "Slc20a2; Pit2", "gene_names_refseq": "MolPit2; Pit-2; Pit2; Ram-1; Ram1; Slc20a2", "protein_names_uniprotkb": "Sodium-dependent phosphate transporter 2; Phosphate transporter 2; PiT-2; Solute carrier family 20 member 2; Type III sodium-dependent phosphate transporter", "protein_names_refseq": "phosphate transporter 2; sodium-dependent phosphate transporter 2; type III sodium-dependent phosphate transporter", "tax_id": 10090, "disease": "basal ganglia calcification (Disease Ontology:DOID:0060230)", "pathway": " (mmu:20516); (R-MMU-427652)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11003594;19144319;21183079;21750661;22872234;23968976;26495903;26822507;30721528;31219806;34428180;39019040", "class_list": "", "function": "Astrocytes modulate brain phosphate homeostasis via polarized distribution of phosphate uptake transporter PiT2 and exporter XPR1., [RefSeq, PubMed]; Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11003594, PubMed:23968976, PubMed:26822507, PubMed:30721528). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (PubMed:30721528). Required to maintain normal cerebrospinal fluid phosphate levels (PubMed:26822507). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (PubMed:23968976)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9462, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QLQ8;Q3TBZ8;Q9ES96", "ec_number_list": "", "go_molecular_function": "GO:0001618 virus receptor activity;GO:0005315 phosphate transmembrane transporter activity;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0030501 positive regulation of bone mineralization;GO:0035435 phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q80UP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXK2-1", "uniprot_id": "RAD18_MOUSE", "mass": 57412.0, "length": 509, "protein_name": "E3 ubiquitin-protein ligase RAD18", "gene_name": "Rad18", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RAD18 isoform 2", "refseq_ac": "NP_067360", "gene_names_uniprotkb": "Rad18; Rad18sc", "gene_names_refseq": "2810024C04Rik; Rad18sc; Rad18", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RAD18; 2.3.2.27; Postreplication repair protein RAD18; RING-type E3 ubiquitin transferase RAD18; mRAD18Sc", "protein_names_refseq": "E3 ubiquitin-protein ligase RAD18 isoform 2; E3 ubiquitin-protein ligase RAD18; RAD18 homolog; RING-type E3 ubiquitin transferase RAD18; mRAD18Sc; post-replication repair protein RAD18SC; postreplication repair protein RAD18", "tax_id": 10090, "disease": "", "pathway": " (mmu:58186); (R-MMU-110314); (R-MMU-8866654)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11013078;12509447;15383616;21183079;21750661;34428180;35459258", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Genome-wide CRISPR screen identified Rad18 as a determinant of doxorubicin sensitivity in osteosarcoma. Publication Status: Online-Only, [RefSeq, PubMed]; RAD18 contributes to maintenance of genomic stability through postreplication repair, [RefSeq, PubMed]; Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZB8", "ec_number_list": "2.7.7.7;3.1.11.-;2.3.2.23;2.3.2.27;2.3.2.32;3.6.4.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0051984 positive regulation of chromosome segregation;GO:0006281 DNA repair;GO:0007283 spermatogenesis;GO:0006974 DNA damage response;GO:0009411 response to UV", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QXK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1P0-1", "uniprot_id": "PSA4_MOUSE", "mass": 29471.0, "length": 261, "protein_name": "Proteasome subunit alpha type-4", "gene_name": "Psma4", "organism": "Mouse", "refseq_name": "proteasome subunit alpha type-4 isoform 1", "refseq_ac": "NP_036096", "gene_names_uniprotkb": "Psma4", "gene_names_refseq": "C9; Psma4", "protein_names_uniprotkb": "Proteasome subunit alpha type-4; Macropain subunit C9; Multicatalytic endopeptidase complex subunit C9; Proteasome component C9; Proteasome subunit L; Proteasome subunit alpha-3; alpha-3", "protein_names_refseq": "alpha-3; macropain subunit C9; multicatalytic endopeptidase complex subunit C9; proteasome (prosome, macropain) subunit, alpha type 4; proteasome component C9; proteasome subunit L; proteasome subunit alpha type-4 isoform 1; proteasome subunit alpha type-4; proteasome subunit alpha-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:26441); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 58, "publication_count": 12, "publication_id_list": "10436176;16581775;16857966;21750661;22078707;22341445;26740625;27802388;33262216;34428180;37116777;37507081", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice., [RefSeq, PubMed]; Proteasome subunit alpha4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in spermatocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THT1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9R1P0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCP2-1", "uniprot_id": "S38A3_MOUSE", "mass": 55592.0, "length": 505, "protein_name": "Sodium-coupled neutral amino acid transporter 3", "gene_name": "Slc38a3", "organism": "Mouse", "refseq_name": "sodium-coupled neutral amino acid transporter 3", "refseq_ac": "NP_001186146", "gene_names_uniprotkb": "Slc38a3; Sn1; Snat3", "gene_names_refseq": "0610012J02Rik; D9Ucla2; Nat1; Slc38-3; Slc38a3; Sn1; Snat3; mNAT", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid transporter 3; N-system amino acid transporter 1; Na(+)-coupled neutral amino acid transporter 3; Solute carrier family 38 member 3; System N amino acid transporter 1; mNAT", "protein_names_refseq": "N system amino acids transporter NAT-1; N-system amino acid transporter 1; Na(+)-coupled neutral amino acid transporter 3; sodium-coupled neutral amino acid transporter 3; system N amino acid transporter 1", "tax_id": 10090, "disease": "metabolic acidosis (Disease Ontology:DOID:0050758); developmental and epileptic encephalopathy 102 (Disease Ontology:DOID:0070388)", "pathway": " (mmu:76257); (R-MMU-352230)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10716701;15899884;16249471;18689705;19458124;21364602;21750661;22645316;24854847;26490457;29561757;30017230;30084848;30634395;32046769;34428180;35820727", "class_list": "", "function": "Choroid plexus LAT2 and SNAT3 as partners in CSF amino acid homeostasis maintenance. Publication Status: Online-Only, [RefSeq, PubMed]; Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10716701, PubMed:15899884, PubMed:16249471, PubMed:18689705, PubMed:29561757, PubMed:30017230). Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (PubMed:18689705, PubMed:29561757, PubMed:30017230). The transport activity is specific for L-glutamine, L-histidine and L-asparagine (PubMed:10716701, PubMed:15899884, PubMed:16249471, PubMed:18689705, PubMed:29561757, PubMed:30017230). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10716701, PubMed:16249471, PubMed:18689705). Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (PubMed:26490457)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The results demonstrate the regulatory role of Sp1 in regulation of SN1 expression and activity in ammonia-treated astrocytes and implicate altered Sp1 phosphorylation status in this capacity. Publication Status: Online-Only, [RefSeq, PubMed]; This indicates a role for PKC in dynamically controlling the trafficking of SNAT3 transporters in astrocytes in situ. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BS53;Q9JLL8", "ec_number_list": "", "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0005290 L-histidine transmembrane transporter activity;GO:0015182 L-asparagine transmembrane transporter activity;GO:0005295 neutral L-amino acid:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:1903713 asparagine transmembrane transport;GO:0051365 cellular response to potassium ion starvation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007565 female pregnancy;GO:0006868 glutamine transport", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9DCP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80Y19-1", "uniprot_id": "RHGBA_MOUSE", "mass": 108436.0, "length": 987, "protein_name": "Rho GTPase-activating protein 11A", "gene_name": "Arhgap11a", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 11A", "refseq_ac": "NP_852081", "gene_names_uniprotkb": "Arhgap11a; Kiaa0013", "gene_names_refseq": "6530401L14Rik; Arhgap11a; mKIAA0013", "protein_names_uniprotkb": "Rho GTPase-activating protein 11A; Rho-type GTPase-activating protein 11A", "protein_names_refseq": "GAP (1-12); rho GTPase-activating protein 11A; rho-type GTPase-activating protein 11A", "tax_id": 10090, "disease": "", "pathway": " (mmu:228482); (R-MMU-8980692)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21183079;21750661;34428180;36924763;37302068", "class_list": "", "function": "ArhGAP11A mediates amyloid-beta generation and neuropathology in an Alzheimer's disease-like mouse model., [RefSeq, PubMed]; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AL17;Q6ZQL1", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007165 signal transduction;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80Y19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88892-1", "uniprot_id": "SERF1_MOUSE", "mass": 7322.0, "length": 62, "protein_name": "Small EDRK-rich factor 1", "gene_name": "Serf1", "organism": "Mouse", "refseq_name": "small EDRK-rich factor 1", "refseq_ac": "NP_035483", "gene_names_uniprotkb": "Serf1", "gene_names_refseq": "4F5; Msmac1; Serf1; m4F5", "protein_names_uniprotkb": "Small EDRK-rich factor 1; Protein 4F5; m4F5", "protein_names_refseq": "modifier of spinal muscular atrophy candidate 1; protein 4F5; small EDRK-rich factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20365)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10486205;21750661;31034892;9731538", "class_list": "", "function": "Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:1990000 amyloid fibril formation;GO:0031648 protein destabilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88892-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61493-1", "uniprot_id": "REV3L_MOUSE", "mass": 350711.0, "length": 3122, "protein_name": "DNA polymerase zeta catalytic subunit", "gene_name": "Rev3l", "organism": "Mouse", "refseq_name": "DNA polymerase zeta catalytic subunit", "refseq_ac": "NP_035394", "gene_names_uniprotkb": "Rev3l; Polz; Sez4", "gene_names_refseq": "Rev3l; Rev3; Rev; Sez4", "protein_names_uniprotkb": "DNA polymerase zeta catalytic subunit; 2.7.7.7; Protein reversionless 3-like; REV3-like; Seizure-related protein 4", "protein_names_refseq": "DNA polymerase zeta catalytic subunit; REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like; seizure-related protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:19714); (R-MMU-110312); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10102037;21183079;21750661;22859295;25428506;25605945;30084848;30779550;31219806;33544859;33626348;34428180;34533226;34597596;35820727;8645260", "class_list": "", "function": "Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function., [UniProtKB, UniProtKB]; DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability., [RefSeq, PubMed]; Disruption of DNA polymerase zeta engages an innate immune response., [RefSeq, PubMed]; The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair., [RefSeq, PubMed]; The role of DNA polymerase zeta in benzo[a]pyrene-induced mutagenesis in the mouse lung., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9Q1X0;Q9JMD6;Q9QWX6", "ec_number_list": "2.7.7.49;3.1.11.-;2.7.7.31;3.1.21.-;2.7.7.7;4.2.99.-;2.7.7.102;5.6.2.-;4.2.99.18;2.7.7.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0016035 zeta DNA polymerase complex;GO:0090734 site of DNA damage;GO:0031981 nuclear lumen", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006281 DNA repair;GO:0000724 double-strand break repair via homologous recombination;GO:0019985 translesion synthesis;GO:0042276 error-prone translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q61493-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AR50-1", "uniprot_id": "RGPS1_MOUSE", "mass": 65475.0, "length": 585, "protein_name": "Ras-specific guanine nucleotide-releasing factor RalGPS1", "gene_name": "Ralgps1", "organism": "Mouse", "refseq_name": "ras-specific guanine nucleotide-releasing factor RalGPS1 isoform b", "refseq_ac": "NP_001277499", "gene_names_uniprotkb": "Ralgps1; Kiaa0351; Ralgef2; Ralgps1a", "gene_names_refseq": "5830418G11Rik; RALGEF2; RALGPS1A; RalGEF 2; Ralgps1; mKIAA0351", "protein_names_uniprotkb": "Ras-specific guanine nucleotide-releasing factor RalGPS1; Ral GEF with PH domain and SH3-binding motif 1; Ral guanine nucleotide exchange factor 2; RalA exchange factor RalGPS1; RalGEF 2", "protein_names_refseq": "Ral guanine nucleotide exchange factor RalGPS1A; ral GEF with PH domain and SH3-binding motif 1; ral guanine nucleotide exchange factor 2; ralA exchange factor RalGPS1; ras-specific guanine nucleotide-releasing factor RalGPS1 isoform b; ras-specific guanine nucleotide-releasing factor RalGPS1", "tax_id": 10090, "disease": "", "pathway": " (mmu:241308)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16648489;21750661;34428180", "class_list": "", "function": "Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeleton organization., [UniProtKB]; Ralgps1 is both necessary and sufficient for the inhibition of myeloid differentiation by Ras., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AR51;A2AR52;Q6GQS4;Q6ZQD2;Q8BVR9;Q8C1I2", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0032485 regulation of Ral protein signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2AR50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG26-1", "uniprot_id": "RUSC1_MOUSE", "mass": 95195.0, "length": 893, "protein_name": "AP-4 complex accessory subunit RUSC1", "gene_name": "Rusc1", "organism": "Mouse", "refseq_name": "AP-4 complex accessory subunit RUSC1 isoform 2", "refseq_ac": "NP_001077276", "gene_names_uniprotkb": "Rusc1; Nesca", "gene_names_refseq": "2210403N08Rik; NESCA; Rusc1", "protein_names_uniprotkb": "AP-4 complex accessory subunit RUSC1; Nesca; New molecule containing SH3 at the carboxy-terminus; RUN and SH3 domain-containing protein 1", "protein_names_refseq": "AP-4 complex accessory subunit RUSC1 isoform 2; AP-4 complex accessory subunit RUSC1; RUN and SH3 domain-containing protein 1; new molecule containing SH3 at the carboxy-terminus", "tax_id": 10090, "disease": "", "pathway": " (mmu:72296)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15024033;21750661;22404429;25428506", "class_list": "", "function": "Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Signaling adapter which plays a role in neuronal differentiation. Involved in regulation of NGF-dependent neurite outgrowth (By similarity). May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (PubMed:22404429). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway (By similarity)., [UniProtKB, PubMed, UniProtKB]; Data suggest that Nesca serves a novel, nuclear-dependent role in neurotrophin-dependent neurite outgrowth., [RefSeq, PubMed]; Nesca functions as an adapter involved in neuronal vesicular transport, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PHT9", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BG26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KK1-1", "uniprot_id": "REEP3_MOUSE", "mass": 29214.0, "length": 254, "protein_name": "Receptor expression-enhancing protein 3", "gene_name": "Reep3", "organism": "Mouse", "refseq_name": "receptor expression-enhancing protein 3 isoform 2", "refseq_ac": "NP_848721", "gene_names_uniprotkb": "Reep3; D10Ucla1", "gene_names_refseq": "D10Ucla1; Reep3", "protein_names_uniprotkb": "Receptor expression-enhancing protein 3", "protein_names_refseq": "receptor expression-enhancing protein 3 isoform 2; receptor expression-enhancing protein 3", "tax_id": 10090, "disease": "hereditary spastic paraplegia 31 (Disease Ontology:DOID:0110782)", "pathway": " (mmu:28193)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15550249;17242355;19144319;21183079;21750661;25428506;30084848;34428180", "class_list": "", "function": "Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZM8;Q9D8G3", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005881 cytoplasmic microtubule;GO:0071782 endoplasmic reticulum tubular network;GO:0005874 microtubule", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0051301 cell division;GO:0007084 mitotic nuclear membrane reassembly;GO:0006998 nuclear envelope organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99KK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35278-1", "uniprot_id": "RAB5C_MOUSE", "mass": 23413.0, "length": 216, "protein_name": "Ras-related protein Rab-5C", "gene_name": "Rab5c", "organism": "Mouse", "refseq_name": "ras-related protein Rab-5C isoform 1", "refseq_ac": "NP_077776", "gene_names_uniprotkb": "Rab5c", "gene_names_refseq": "Rab5c; Rabl", "protein_names_uniprotkb": "Ras-related protein Rab-5C; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-5C isoform 1; ras-related protein Rab-5C", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:19345); (R-MMU-432722); (R-MMU-6798695); (R-MMU-8856828); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 6, "publication_count": 24, "publication_id_list": "11278565;11465105;1555775;18250455;20173027;21750661;22645316;25153642;25428506;26495903;26740625;28011936;28935714;29187734;30084848;33300544;34428180;35820727;35984892;37507081;37828378;38242290;39627609;9707606", "class_list": "", "function": "Rab5c promotes RSV and ADV replication by autophagy in respiratory epithelial cells., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in early endocytic trafficking. Required for EEA1 recruitment to early endosomes. Required for EGF and transferrin endocytosis and trafficking through early endosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1V8;Q8R2N8", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.4.17.22;3.6.5.4;2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;2.3.2.27;5.6.1.6;3.6.5.5;3.4.23.-;2.5.1.60;3.6.4.-;3.6.4.10;3.2.1.20;7.6.2.1;2.7.10.1;3.6.1.-;3.6.1.15;2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;2.7.11.1;7.6.2.-;2.7.1.153;2.7.1.137;2.7.1.154;3.1.3.86;3.1.3.56;3.1.3.36;3.4.16.2;3.1.3.-;3.6.-.-;3.1.3.5;3.1.3.2;3.1.3.48;3.2.1.25;2.5.1.18;3.5.1.92", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0030100 regulation of endocytosis;GO:0007032 endosome organization;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P35278-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ER71-1", "uniprot_id": "RHOJ_MOUSE", "mass": 23766.0, "length": 214, "protein_name": "Rho-related GTP-binding protein RhoJ", "gene_name": "Rhoj", "organism": "Mouse", "refseq_name": "rho-related GTP-binding protein RhoJ", "refseq_ac": "NP_075764", "gene_names_uniprotkb": "Rhoj; Arhj; Rhoi; Rhot; Tc10l; Tcl", "gene_names_refseq": "1110005O19Rik; Arhj; Rhoj; TC10L; TCL", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoJ; 3.6.5.2; Tc10-like GTP-binding protein", "protein_names_refseq": "TC10-like Rho GTPase; ras homolog gene family, member J; rho-related GTP-binding protein RhoJ; tc10-like GTP-binding protein TCL", "tax_id": 10090, "disease": "", "pathway": " (mmu:80837); (R-MMU-9013409)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10967094;11821390;12456725;12578843;21750661;36949199;38247865", "class_list": "", "function": "Cloning and functional characterization of related isoforms, [RefSeq, PubMed]; Plasma membrane-associated small GTPase specifically involved in angiogenesis (By similarity). Required for endothelial cell migration during vascular development via its interaction with GLUL (By similarity). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:10967094)., [UniProtKB, UniProtKB, PubMed]; RHOJ controls EMT-associated resistance to chemotherapy., [RefSeq, PubMed]; TCL/TC10betaL has a crucial role in the early stage of adipocyte differentiation, is probably linked to the PPARgamma pathway, and up-regulates epression of genes associated with adipogenesis., [RefSeq, PubMed]; Towards Understanding the Development of Breast Cancer: The Role of RhoJ in the Obesity Microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TX76;Q920E4;Q9CQA7", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;2.7.11.1;3.6.1.15;3.1.3.86;3.1.3.56;3.1.3.36;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ER71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5FWH7-1", "uniprot_id": "S39AC_MOUSE", "mass": 76215.0, "length": 689, "protein_name": "Zinc transporter ZIP12", "gene_name": "Slc39a12", "organism": "Mouse", "refseq_name": "zinc transporter ZIP12 isoform 1 precursor", "refseq_ac": "NP_001012305", "gene_names_uniprotkb": "Slc39a12; Zip12", "gene_names_refseq": "Gm731; Slc39a12", "protein_names_uniprotkb": "Zinc transporter ZIP12; Solute carrier family 39 member 12; ZIP-12; Zrt- and Irt-like protein 12", "protein_names_refseq": "ZIP-12; solute carrier family 39 member 12; zinc transporter ZIP12 isoform 1 precursor; zinc transporter ZIP12; zrt- and Irt-like protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:277468)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23716681;30899004;34418053;34428180;35065654;35820727", "class_list": "", "function": "Data indicate that ZIP12 (slc39a12) is a Zn(2+) uptake transporter with a conserved pattern of high expression in the mouse and Xenopus nervous system., [RefSeq, PubMed]; Uniporter that promotes Zn(2+) import from the extracellular space to the cytoplasm across the cell membrane (PubMed:23716681, PubMed:35065654). The transport activity is temperature dependent (PubMed:23716681). May play a role in neurulation and neurite extension (PubMed:23716681). May play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis (PubMed:35065654)., [UniProtKB, PubMed, PubMed]; Zinc transporter ZIP12 maintains zinc homeostasis and protects spermatogonia from oxidative stress during spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AQ76", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0140410 monoatomic cation:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0007165 signal transduction;GO:0031113 regulation of microtubule polymerization;GO:0010975 regulation of neuron projection development;GO:0030003 intracellular monoatomic cation homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q5FWH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJL0-1", "uniprot_id": "SMAL1_MOUSE", "mass": 100840.0, "length": 910, "protein_name": "SNF2 related chromatin remodeling annealing helicase 1", "gene_name": "Smarcal1", "organism": "Mouse", "refseq_name": "SNF2 related chromatin remodeling annealing helicase 1", "refseq_ac": "NP_061287", "gene_names_uniprotkb": "Smarcal1; Harp", "gene_names_refseq": "6030401P21Rik; Mharp; Smarcal1", "protein_names_uniprotkb": "SNF2 related chromatin remodeling annealing helicase 1; 3.6.4.-; 5.6.2.-; HepA-related protein; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; Sucrose nonfermenting protein 2-like 1; mharp", "protein_names_refseq": "SNF2 related chromatin remodeling annealing helicase 1; SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; hepA-related protein; sucrose nonfermenting protein 2-like 1", "tax_id": 10090, "disease": "Schimke immuno-osseous dysplasia (Disease Ontology:DOID:0060490)", "pathway": " (mmu:54380)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10857751;21750661;22378147;22888040;25428506;34428180;38301646", "class_list": "", "function": "ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks., [UniProtKB, UniProtKB]; Did not find evidence of defective NER or NHEJ; however, Smarcal1-deficient mice were hypersensitive to several genotoxic agents, [RefSeq, PubMed]; SMARCAL1 annealing helicase buffers fluctuations in gene expression and that alterations in gene expression contribute to the penetrance of SIOD., [RefSeq, PubMed]; SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEQ9;Q3U4W0;Q3V3A8;Q8BVK7;Q8BXW4;Q8K309;Q9EQK8;Q9QYC4", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036310 ATP-dependent DNA/DNA annealing activity;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0005662 DNA replication factor A complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BJL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1X6-1", "uniprot_id": "SPART_MOUSE", "mass": 72655.0, "length": 671, "protein_name": "Spartin", "gene_name": "Spart", "organism": "Mouse", "refseq_name": "spartin isoform a", "refseq_ac": "NP_001138459", "gene_names_uniprotkb": "Spart; Kiaa0610; Spg20", "gene_names_refseq": "Spart; Spg20; TAHCCP1; mKIAA0610", "protein_names_uniprotkb": "Spartin", "protein_names_refseq": "spartin isoform a; spastic paraplegia 20, spartin (Troyer syndrome) homolog", "tax_id": 10090, "disease": "Troyer syndrome (Disease Ontology:DOID:0050886)", "pathway": " (mmu:229285)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10.1101/2023.09.13.557529;16036216;17242355;21183079;21559443;21750661;22517741;22619377;22645316;25153642;26495903;28135057;28324774;28528544;30059200;31194837;31219806;31535723;32782141;34428180;35820727;35822049;36210013;36288343;36852467;37443287;40021952;40885482", "class_list": "", "function": "A role for spartin in lipid droplets maintenance and in the regulation of cytokinesis, [RefSeq, PubMed]; Findings evidence a positive correlation between SIRT1 and BCL6 expression increase in follicular lymphomas (FL) . SIRT1 methylation decreases in FL and diffuse large-B cell lymphomas (DLBCL)and this parallels the increase of KLF4, DAPK1 and SPG20 methylation, [RefSeq, PubMed]; Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons (PubMed:37443287). Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy. Lipid transfer protein required for lipid droplet degradation, including by lipophagy. Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown. May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (By similarity)., [UniProtKB, UniProtKB, PubMed]; Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons. Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy. Lipid transfer protein required for lipid droplet degradation, including by lipophagy. Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown. May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our results suggest that spartin might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome., [RefSeq, PubMed]; SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2+ homeostasis Publication Status: Online-Only, [RefSeq, PubMed]; SPG20, a potential STAT3 target, is frequently methylated in gastric cancer, representing a novel noninvasive biomarker for early detection of this deadly disease. Publication Status: Online-Only, [RefSeq, PubMed]; Troyer syndrome with Dwarfism was diagnosed in a family caused by SPG20 compound heterozygous mutations. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZQ87;Q8BJD3;Q8BM37;Q8BZ63", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0048698 negative regulation of collateral sprouting in absence of injury;GO:0006869 lipid transport;GO:0050905 neuromuscular process;GO:0051301 cell division;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q8R1X6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P86049-1", "uniprot_id": "RBM46_MOUSE", "mass": 60077.0, "length": 533, "protein_name": "Probable RNA-binding protein 46", "gene_name": "Rbm46", "organism": "Mouse", "refseq_name": "probable RNA-binding protein 46 isoform 1", "refseq_ac": "NP_001139800", "gene_names_uniprotkb": "Rbm46", "gene_names_refseq": "EG633285; Gm761; Rbm46", "protein_names_uniprotkb": "Probable RNA-binding protein 46; RNA-binding motif protein 46", "protein_names_refseq": "probable RNA-binding protein 46 isoform 1; probable RNA-binding protein 46", "tax_id": 10090, "disease": "", "pathway": " (mmu:633285)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;25397698;30084848;36001654;36129965;36726756;38518724", "class_list": "", "function": "Essential for male and female fertility, playing a crucial role in regulating germ cell development by ensuring the proper progression of meiosis prophase I (PubMed:36001654, PubMed:36129965, PubMed:36726756). Regulates mitotic-to-meiotic transition in spermatogenesis by forming a complex with MEIOC and YTHDC2 which recognizes and down-regulates mitotic transcripts for a successful meiotic entry (PubMed:36129965). Required for normal synaptonemal complex formation during meiosis, binding meiotic cohesin subunit mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions and positively regulating their translation (PubMed:36726756). Required for spermatogonial differentiation in both developing and adult testis (PubMed:36129965)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits. Erratum:[Protein Cell. 2025 Oct 31;16(10):917. doi: 10.1093/procel/pwaf038. PMID: 40391757] Publication Status: Online-Only, [RefSeq, PubMed]; RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis., [RefSeq, PubMed]; Rbm46 directly binds to and stabilizes Cdx2 mRNA in early mouse embryos., [RefSeq, PubMed]; Rbm46 inhibits reactive oxygen species in mouse embryonic stem cells through modulating BNIP3-mediated mitophagy., [RefSeq, PubMed]; The germ cell-specific RNA binding protein RBM46 is essential for spermatogonial differentiation in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0048255 mRNA stabilization;GO:0001829 trophectodermal cell differentiation;GO:0007143 female meiotic nuclear division;GO:0007140 male meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P86049-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4X3-1", "uniprot_id": "RBM12_MOUSE", "mass": 102796.0, "length": 992, "protein_name": "RNA-binding protein 12", "gene_name": "Rbm12", "organism": "Mouse", "refseq_name": "RNA-binding protein 12", "refseq_ac": "NP_083673", "gene_names_uniprotkb": "Rbm12", "gene_names_refseq": "5730420G12Rik; 9430070C08Rik; Rbm12; SWAN; mKIAA0765", "protein_names_uniprotkb": "RNA-binding protein 12; RNA-binding motif protein 12; SH3/WW domain anchor protein in the nucleus; SWAN", "protein_names_refseq": "RNA-binding protein 12; SH3/WW domain anchor protein in the nucleus", "tax_id": 10090, "disease": "schizophrenia 19 (Disease Ontology:DOID:0080281)", "pathway": " (mmu:75710)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;32782141;32848054;34428180;40021952;40885482;40997131", "class_list": "", "function": "This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 2 H2. Two alternatively spliced transcript variants have been identified for this gene. Both variants encode the same protein. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "B6ICZ5;Q3TKT7;Q7TT14;Q8K373;Q8R302;Q9CS80", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8R4X3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGB8-1", "uniprot_id": "SMCA1_MOUSE", "mass": 121715.0, "length": 1046, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1", "gene_name": "Smarca1", "organism": "Mouse", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 isoform 2", "refseq_ac": "NP_001277637", "gene_names_uniprotkb": "Smarca1; Snf2l", "gene_names_refseq": "5730494M04Rik; Smarca1; Snf2l", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1; 3.6.4.-; DNA-dependent ATPase SNF2L; Global transcription activator SNF2L1; Nucleosome-remodeling factor subunit SNF2L; SMARCA1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1", "protein_names_refseq": "ATP-dependent helicase SMARCA1; DNA-dependent ATPase SNF2L; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 isoform 2; nucleosome-remodeling factor subunit SNF2L; probable global transcription activator SNF2L1", "tax_id": 10090, "disease": "central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (mmu:93761)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11359880;14609955;16740656;20485683;21750661;34197713;34428180", "class_list": "", "function": "ATPase that possesses intrinsic ATP-dependent chromatin-remodeling activity. ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate. Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template. Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes. The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template. Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. May promote neurite outgrowth. May be involved in the development of luteal cells. Facilitates nucleosome assembly during DNA replication, ensuring replication fork progression and genomic stability by preventing replication stress and nascent DNA gaps., [UniProtKB, UniProtKB]; The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AUP6;B1AUP7;Q8BSS1;Q91Y58", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036310 ATP-dependent DNA/DNA annealing activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0016589 NURF complex;GO:0090537 CERF complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6PGB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5HZH7-1", "uniprot_id": "S38A8_MOUSE", "mass": 46898.0, "length": 432, "protein_name": "Solute carrier family 38 member 8", "gene_name": "Slc38a8", "organism": "Mouse", "refseq_name": "solute carrier family 38 member 8", "refseq_ac": "NP_001009950", "gene_names_uniprotkb": "Slc38a8; Gm587", "gene_names_refseq": "Gm587; Slc38a8", "protein_names_uniprotkb": "Solute carrier family 38 member 8; Amino acid transporter SLC38A8", "protein_names_refseq": "amino acid transporter SLC38A8; putative sodium-coupled neutral amino acid transporter 8; solute carrier family 38 member 8", "tax_id": 10090, "disease": "foveal hypoplasia 2 (Disease Ontology:DOID:0070531)", "pathway": " (mmu:234788)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;24045842;25428506;25451601;36735752", "class_list": "", "function": "Electrogenic sodium-dependent amino acid transporter with a preference for L-glutamine, L-alanine, L-histidine, L-aspartate and L-arginine. May facilitate glutamine uptake in both excitatory and inhibitory neurons. The transport mechanism and stoichiometry remain to be elucidated., [UniProtKB, PubMed]; Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005938 cell cortex;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0031175 neuron projection development;GO:0006531 aspartate metabolic process;GO:0007601 visual perception;GO:0009615 response to virus;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5HZH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91X05-1", "uniprot_id": "PODO_MOUSE", "mass": 42337.0, "length": 385, "protein_name": "Podocin", "gene_name": "Nphs2", "organism": "Mouse", "refseq_name": "podocin", "refseq_ac": "NP_569723", "gene_names_uniprotkb": "Nphs2", "gene_names_refseq": "Nphs2; PDCN; SRN1", "protein_names_uniprotkb": "Podocin", "protein_names_refseq": "nephrosis 2 homolog, podocin; podocin", "tax_id": 10090, "disease": "nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); membranous glomerulonephritis (Disease Ontology:DOID:10976); nephrotic syndrome (Disease Ontology:DOID:1184); proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:170484); (R-MMU-373753)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11562357;11733557;12424224;17537921;21750661;39145457", "class_list": "", "function": "Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWE6;Q91Z95", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0045121 membrane raft;GO:0071944 cell periphery;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0010467 gene expression;GO:0072249 metanephric podocyte development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91X05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924N9-1", "uniprot_id": "PRS28_MOUSE", "mass": 30628.0, "length": 274, "protein_name": "Serine protease 28", "gene_name": "Prss28", "organism": "Mouse", "refseq_name": "serine protease 28 precursor", "refseq_ac": "NP_444489", "gene_names_uniprotkb": "Prss28; Isp1", "gene_names_refseq": "Isp1; Prss28; mIsp-1", "protein_names_uniprotkb": "Serine protease 28; 3.4.21.-; ISP-1; Implantation serine proteinase 1; Strypsin; Tryptase-like proteinase", "protein_names_refseq": "ISP-1; implantation serine protease 1; implantation serine proteinase 1; protease, serine 28; serine protease 28 precursor; strypsin; tryptase-like proteinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:114661)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11425330;12112596;15293213;15349836;16257142;17156484;21750661;22132161;28993437;33973295", "class_list": "", "function": "Generation and analysis of Prss28 and Prss29 deficient mice using CRISPR-Cas9 genome-editing., [RefSeq, PubMed]; Hypothyroidism induces a significant reduction of proteases Isp1 and Isp2 gene expressions and Notch signaling., [RefSeq, PubMed]; ISP1 might signal to cells by cleaving and activating proteinase-activated receptors (PARs) and therefore assessed PARs 1, 2 and 4 as potential ISP1 targets., [RefSeq, PubMed]; ISP1 plays a critical role in embryo hatching and implantation Publication Status: Online-Only, [RefSeq, PubMed]; Involved in embryo hatching and implantation., [UniProtKB, PubMed, PubMed, PubMed]; Organization, structure and postulated function of the implantation serine proteinase (ISP1 and 2) genes., [RefSeq, PubMed]; The ISP1 and ISP2 genes are co-expressed within the endometrial gland, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UN30", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007566 embryo implantation;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q924N9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6D8-1", "uniprot_id": "PPIL6_MOUSE", "mass": 35562.0, "length": 313, "protein_name": "Probable inactive peptidyl-prolyl cis-trans isomerase-like 6", "gene_name": "Ppil6", "organism": "Mouse", "refseq_name": "probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform 1", "refseq_ac": "NP_082706", "gene_names_uniprotkb": "Ppil6", "gene_names_refseq": "2900084F20Rik; Ppil6", "protein_names_uniprotkb": "Probable inactive peptidyl-prolyl cis-trans isomerase-like 6; Cyclophilin-like protein PPIL6; PPIase", "protein_names_refseq": "PPIase; cyclophilin-like protein PPIL6; peptidyl-prolyl cis-trans isomerase-like 6; probable inactive peptidyl-prolyl cis-trans isomerase-like 6 isoform 1; probable inactive peptidyl-prolyl cis-trans isomerase-like 6; problable inactive peptidyl-prolyl cis-trans isomerase-like 6; rotamase PPIL6", "tax_id": 10090, "disease": "", "pathway": " (mmu:73075)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17971504;21750661", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB]; Ppil6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RWF7", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D6D8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3G1-1", "uniprot_id": "PP1R8_MOUSE", "mass": 38528.0, "length": 351, "protein_name": "Nuclear inhibitor of protein phosphatase 1", "gene_name": "Ppp1r8", "organism": "Mouse", "refseq_name": "nuclear inhibitor of protein phosphatase 1 isoform 2", "refseq_ac": "NP_001277654", "gene_names_uniprotkb": "Ppp1r8; Nipp1", "gene_names_refseq": "6330548N22Rik; NIPP1; Ppp1r8", "protein_names_uniprotkb": "Nuclear inhibitor of protein phosphatase 1; NIPP-1; Protein phosphatase 1 regulatory inhibitor subunit 8", "protein_names_refseq": "nuclear inhibitor of protein phosphatase 1 isoform 2; nuclear inhibitor of protein phosphatase 1; protein phosphatase 1, regulatory (inhibitor) subunit 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:100336); (R-MMU-9770562)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12788942;15199142;15501817;18253837;21750661;25605945;31972250;34428180;36198882;38431220", "class_list": "", "function": "Embryonic NIPP1 Depletion in Keratinocytes Triggers a Cell Cycle Arrest and Premature Senescence in Adult Mice., [RefSeq, PubMed]; Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Essential for cell proliferation and early embryonic development., [UniProtKB, PubMed, PubMed]; NIPP1(-/-) embryos showed severely retarded growth at embryonic day 6.5 (E6.5) and were resorbed by E8.5. This early embryonic lethality was not associated with increased apoptosis but correlated with impaired cell proliferation., [RefSeq, PubMed]; Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS Tau Phosphorylation and Myelination During Development., [RefSeq, PubMed]; Phosphatase Regulator NIPP1 Restrains Chemokine-Driven Skin Inflammation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C087", "ec_number_list": "", "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0019888 protein phosphatase regulator activity;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0008283 cell population proliferation;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R3G1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQJ5-1", "uniprot_id": "PRR13_MOUSE", "mass": 14208.0, "length": 137, "protein_name": "Proline-rich protein 13", "gene_name": "Prr13", "organism": "Mouse", "refseq_name": "proline-rich protein 13", "refseq_ac": "NP_001164382", "gene_names_uniprotkb": "Prr13", "gene_names_refseq": "1110020C13Rik; 2010324E22Rik; Prr13", "protein_names_uniprotkb": "Proline-rich protein 13", "protein_names_refseq": "proline-rich protein 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:66151)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3U4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MS4-1", "uniprot_id": "PRS29_MOUSE", "mass": 30986.0, "length": 279, "protein_name": "Serine protease 29", "gene_name": "Prss29", "organism": "Mouse", "refseq_name": "serine protease 29 precursor", "refseq_ac": "NP_444490", "gene_names_uniprotkb": "Prss29; Isp2", "gene_names_refseq": "Isp2; Prss29; mISP-2", "protein_names_uniprotkb": "Serine protease 29; 3.4.21.-; ISP-2; Implantation serine proteinase 2; Strypsin-2; Strypsin-related protein; Tryptase-like proteinase", "protein_names_refseq": "ISP-2; implantation serine protease 2; implantation serine proteinase 2; protease, serine 29; serine protease 29 precursor; strypsin-2; strypsin-related protein; tryptase-like proteinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:114662)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11467974;12112596;12883636;15293213;15304212;15349836;17156484;21750661;28993437;33973295", "class_list": "", "function": "Generation and analysis of Prss28 and Prss29 deficient mice using CRISPR-Cas9 genome-editing., [RefSeq, PubMed]; Hypothyroidism induces a significant reduction of proteases Isp1 and Isp2 gene expression and Notch signaling., [RefSeq, PubMed]; ISP2 may play an important role during embryo implantation., [RefSeq, PubMed]; Involved in embryo hatching and implantation., [UniProtKB, PubMed, PubMed, PubMed]; The ISP1 and ISP2 genes are co-expressed within the endometrial gland, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3MI54;Q3UN95", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007566 embryo implantation;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99MS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAZ2-1", "uniprot_id": "PR2B1_MOUSE", "mass": 25879.0, "length": 228, "protein_name": "Prolactin-2B1", "gene_name": "Prl2b1", "organism": "Mouse", "refseq_name": "prolactin-2B1 precursor", "refseq_ac": "NP_079808", "gene_names_uniprotkb": "Prl2b1; Prlpk", "gene_names_refseq": "2310047B08Rik; Ghd12; PLP-K; Plpk; Prl2b1; Prlpk; mPLP-K", "protein_names_uniprotkb": "Prolactin-2B1; PLP-K; PRL-like protein K; Placental prolactin-like protein K", "protein_names_refseq": "PRL-like protein K; growth hormone d12; placental prolactin-like protein K; prolactin like protein k; prolactin-2B1 precursor; prolactin-2B1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66392)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12488360;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2TA52", "ec_number_list": "", "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DAZ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WM7-1", "uniprot_id": "PRS33_MOUSE", "mass": 29888.0, "length": 277, "protein_name": "Serine protease 33", "gene_name": "Prss33", "organism": "Mouse", "refseq_name": "serine protease 33 precursor", "refseq_ac": "NP_001074868", "gene_names_uniprotkb": "Prss33", "gene_names_refseq": "Eos; Prss33; mT6; tryptase-6", "protein_names_uniprotkb": "Serine protease 33; 3.4.21.-; Tryptase-6; mT6", "protein_names_refseq": "protease, serine 33; serine protease 33 precursor; serine protease EOS; tryptase 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:353130)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14583634;21750661", "class_list": "", "function": "Serine protease that has amidolytic activity, cleaving its substrates before Arg residues., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZB43", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80WM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80XD8-1", "uniprot_id": "PRAP1_MOUSE", "mass": 16798.0, "length": 149, "protein_name": "Proline-rich acidic protein 1", "gene_name": "Prap1", "organism": "Mouse", "refseq_name": "proline-rich acidic protein 1 precursor", "refseq_ac": "NP_033501", "gene_names_uniprotkb": "Prap1; Upa", "gene_names_refseq": "Prap1; Upa", "protein_names_uniprotkb": "Proline-rich acidic protein 1; Pregnancy-specific uterine protein; Uterine-specific proline-rich acidic protein", "protein_names_refseq": "pregnancy-specific uterine protein; proline-rich acidic protein 1 precursor; uterine-specific proline-rich acidic protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:22264)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10899595;20674898;32629119;33168624;9065197", "class_list": "", "function": "Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (PubMed:33168624). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (PubMed:32629119). May play an important role in maintaining normal growth homeostasis in epithelial cells (By similarity). Involved in p53/TP53-dependent cell survival after DNA damage (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; PRAP1 is a marker for successful embryo implantation., [RefSeq, PubMed]; PRAP1 is a novel lipid-binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport., [RefSeq, PubMed]; Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60874", "ec_number_list": "", "go_molecular_function": "GO:0017129 triglyceride binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:1902426 deactivation of mitotic spindle assembly checkpoint;GO:0043066 negative regulation of apoptotic process;GO:0006974 DNA damage response;GO:0030330 DNA damage response, signal transduction by p53 class mediator;GO:0071481 cellular response to X-ray", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80XD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG41-1", "uniprot_id": "PSB11_MOUSE", "mass": 33220.0, "length": 302, "protein_name": "Proteasome subunit beta type-11", "gene_name": "Psmb11", "organism": "Mouse", "refseq_name": "proteasome subunit beta type-11", "refseq_ac": "NP_780413", "gene_names_uniprotkb": "Psmb11", "gene_names_refseq": "5830406J20Rik; Psmb11; beta5t", "protein_names_uniprotkb": "Proteasome subunit beta type-11; 3.4.25.1; Proteasome subunit beta-5t", "protein_names_refseq": "proteasome beta 11 subunit; proteasome subunit beta type-11; proteasome subunit beta-5t; proteasome subunit beta5t", "tax_id": 10090, "disease": "proteasome-associated autoinflammatory syndrome 1 (Disease Ontology:DOID:0050553); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:73902); (R-MMU-9907900)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17540904;21183079;21469133;25428506", "class_list": "", "function": "Results indicate that beta5t expression in thymic cortical epithelial cells is dependent on Foxn1 but independent of thymocyte crosstalk or thymic medulla formation, [RefSeq, PubMed]; Results suggest a key role for proteasome subunit beta5t in generating the MHC class I-restricted CD8(+) T cell repertoire during thymic selection, [RefSeq, PubMed]; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T-cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149K8", "ec_number_list": "3.4.25.1", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0008233 peptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005839 proteasome core complex", "go_biological_process": "GO:0043374 CD8-positive, alpha-beta T cell differentiation;GO:0006508 proteolysis;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0033077 T cell differentiation in thymus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BG41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGL1-1", "uniprot_id": "PPM1N_MOUSE", "mass": 43201.0, "length": 404, "protein_name": "Probable protein phosphatase 1N", "gene_name": "Ppm1n", "organism": "Mouse", "refseq_name": "probable protein phosphatase 1N", "refseq_ac": "NP_808359", "gene_names_uniprotkb": "Ppm1n", "gene_names_refseq": "A930002H20; Ppm1n", "protein_names_uniprotkb": "Probable protein phosphatase 1N; 3.1.3.16", "protein_names_refseq": "probable protein phosphatase 1N", "tax_id": 10090, "disease": "", "pathway": " (mmu:232941)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.1.3.74;3.1.3.53;3.1.3.27;3.1.3.52;3.1.3.86;3.1.3.36", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BGL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGQ4-1", "uniprot_id": "POMT2_MOUSE", "mass": 92386.0, "length": 820, "protein_name": "Protein O-mannosyl-transferase 2", "gene_name": "Pomt2", "organism": "Mouse", "refseq_name": "protein O-mannosyl-transferase 2", "refseq_ac": "NP_700464", "gene_names_uniprotkb": "Pomt2", "gene_names_refseq": "Pomt2", "protein_names_uniprotkb": "Protein O-mannosyl-transferase 2; 2.4.1.109; Dolichyl-phosphate-mannose--protein mannosyltransferase 2", "protein_names_refseq": "dolichyl-phosphate-mannose--protein mannosyltransferase 2; protein O-mannosyl-transferase 2", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274); autosomal recessive limb-girdle muscular dystrophy type 2N (Disease Ontology:DOID:0110298); congenital muscular dystrophy-dystroglycanopathy type A2 (Disease Ontology:DOID:0111240); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); muscular dystrophy-dystroglycanopathy type B2 (Disease Ontology:DOID:0112380); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:217734); (R-MMU-8932504); (R-MMU-8932505); (R-MMU-8932506); (R-MMU-9768727)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12460945;18490429;30084848;31219806;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Molecular cloning and characterization, [RefSeq, PubMed]; Testis POMT2 is highly conserved among mammals, including humans, suggesting a crucial function that is distinct from somatic POMT2, [RefSeq, PubMed]; This gene encodes an integral membrane protein that belongs to the dolichyl-phosphate-mannose-protein mannosyltransferase family. The encoded enzyme is found in the membrane of the endoplasmic reticulum. This protein is a component of the protein O-mannosyltransferase enzyme complex which is involved in modification of the protein alpha-dystroglycan. Mutations in the human gene are a cause of different forms of muscular dystrophy-dystroglycanopathy (MDDG), type A2 (also known as Walker-Warburg syndrome), type B2 and type C2 (also known as limb-girdle muscular dystrophy). [provided by RefSeq, Sep 2015]., [RefSeq]; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 39, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 8, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8R4Z0", "ec_number_list": "2.4.1.109", "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1904100 positive regulation of protein O-linked glycosylation;GO:0006493 protein O-linked glycosylation;GO:0035269 protein O-linked glycosylation via mannose;GO:0021542 dentate gyrus development;GO:0071711 basement membrane organization", "synthesized_glycan_count": 1677, "hit_score": 1.4, "record_id": "Q8BGQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHE0-1", "uniprot_id": "PRR11_MOUSE", "mass": 40949.0, "length": 368, "protein_name": "Proline-rich protein 11", "gene_name": "Prr11", "organism": "Mouse", "refseq_name": "proline-rich protein 11", "refseq_ac": "NP_780772", "gene_names_uniprotkb": "Prr11", "gene_names_refseq": "B930067F20Rik; Prr11", "protein_names_uniprotkb": "Proline-rich protein 11", "protein_names_refseq": "proline-rich protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:270906)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "35980531;37641376", "class_list": "", "function": "ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy., [RefSeq, PubMed]; Identification of proline-rich protein 11 as a major regulator in mouse spermatogonia maintenance via an increase in BMI1 protein stability., [RefSeq, PubMed]; Plays a critical role in cell cycle progression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KGQ3;Q3V3H1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BHE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJR6-1", "uniprot_id": "PRS27_MOUSE", "mass": 35789.0, "length": 328, "protein_name": "Serine protease 27", "gene_name": "Prss27", "organism": "Mouse", "refseq_name": "serine protease 27 precursor", "refseq_ac": "NP_780649", "gene_names_uniprotkb": "Prss27; Mpn", "gene_names_refseq": "CAPH2; Mpn; Prss27; marapsin", "protein_names_uniprotkb": "Serine protease 27; 3.4.21.-; Marapsin; Pancreasin", "protein_names_refseq": "channel-activating protease 2-like protein; pancreasin; protease, serine 27; serine protease 27 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:213171)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12441343;18948266;23447538", "class_list": "", "function": "Marapsin's restricted expression, localization, and cytokine-inducible expression suggest a role in the terminal differentiation of keratinocytes in hyperproliferating squamous epithelia., [RefSeq, PubMed]; Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14A25", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BJR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKR5-1", "uniprot_id": "PPR37_MOUSE", "mass": 77574.0, "length": 712, "protein_name": "Protein phosphatase 1 regulatory subunit 37", "gene_name": "Ppp1r37", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 37", "refseq_ac": "NP_954600", "gene_names_uniprotkb": "Ppp1r37; Lrrc68", "gene_names_refseq": "Gm158; Lrrc68; Ppp1r37", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 37; Leucine-rich repeat-containing protein 68", "protein_names_refseq": "leucine rich repeat containing 68; leucine-rich repeat-containing protein 68; protein phosphatase 1 regulatory subunit 37", "tax_id": 10090, "disease": "", "pathway": " (mmu:232947)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;35820727", "class_list": "", "function": "Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BKR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C167-1", "uniprot_id": "PPCEL_MOUSE", "mass": 83194.0, "length": 725, "protein_name": "Prolyl endopeptidase-like", "gene_name": "Prepl", "organism": "Mouse", "refseq_name": "prolyl endopeptidase-like isoform a", "refseq_ac": "NP_001157094", "gene_names_uniprotkb": "Prepl; Kiaa0436", "gene_names_refseq": "2810457N15Rik; 9530014L06Rik; D030028O16Rik; Prepl; mKIAA0436", "protein_names_uniprotkb": "Prolyl endopeptidase-like; 3.4.21.-; Prolylendopeptidase-like", "protein_names_refseq": "prolyl endopeptidase-like isoform a", "tax_id": 10090, "disease": "congenital myasthenic syndrome 22 (Disease Ontology:DOID:0080587)", "pathway": " (mmu:213760)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21183079;21692504;21750661;23321636;23485813;24586561;25428506;25605945;30084848;34428180;37147110", "class_list": "", "function": "Multiomics Analyses Identify Proline Endopeptidase-Like Protein As a Key Regulator of Protein Trafficking, a Pathway Underlying Alzheimer's Disease Pathogenesis., [RefSeq, PubMed]; Serine peptidase whose precise substrate specificity remains unclear (PubMed:21692504). Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (PubMed:23321636). May play a role in the regulation of synaptic vesicle exocytosis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; The data demonstrate PREPL as an AP-1 effector that takes part in the regulation of AP-1 membrane binding. PREPL is highly expressed in brain and at lower levels in muscle and kidney., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TR35;Q6ZQB4;Q8BUP5;Q99KJ9", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006508 proteolysis;GO:0043001 Golgi to plasma membrane protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8C167-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CEC6-1", "uniprot_id": "PPWD1_MOUSE", "mass": 73385.0, "length": 646, "protein_name": "Peptidylprolyl isomerase domain and WD repeat-containing protein 1", "gene_name": "Ppwd1", "organism": "Mouse", "refseq_name": "peptidylprolyl isomerase domain and WD repeat-containing protein 1", "refseq_ac": "NP_766395", "gene_names_uniprotkb": "Ppwd1", "gene_names_refseq": "4632422M10Rik; A330090G21Rik; Ppwd1", "protein_names_uniprotkb": "Peptidylprolyl isomerase domain and WD repeat-containing protein 1; 5.2.1.8", "protein_names_refseq": "peptidylprolyl isomerase domain and WD repeat-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:238831); (R-MMU-72163)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "25428507;25605945;31219806;34428180", "class_list": "", "function": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VEA0", "ec_number_list": "3.6.4.13;5.2.1.8;3.1.13.-;2.7.7.48;2.7.7.6;3.6.4.10;2.3.2.27", "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0016604 nuclear body;GO:0071013 catalytic step 2 spliceosome;GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CEC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGZ9-1", "uniprot_id": "PR7B1_MOUSE", "mass": 28960.0, "length": 251, "protein_name": "Prolactin-7B1", "gene_name": "Prl7b1", "organism": "Mouse", "refseq_name": "prolactin-7B1 precursor", "refseq_ac": "NP_083631", "gene_names_uniprotkb": "Prl7b1; Prlpn", "gene_names_refseq": "1600014J19Rik; Ghd17; PLP-N; Prl7b1; Prlpn", "protein_names_uniprotkb": "Prolactin-7B1; PLP-N; PRL-like protein N; Placental prolactin-like protein N", "protein_names_refseq": "PRL-like protein N; growth hormone d17; placental prolactin-like protein N; prolactin-7B1 precursor; prolactin-7B1; prolactin-like protein N", "tax_id": 10090, "disease": "", "pathway": " (mmu:75596)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12488360;12885563", "class_list": "", "function": "Invading mouse trophoblast cells possess endocrine activities, including the expression of PLP-N., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q14AN3;Q9DAX1", "ec_number_list": "", "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CGZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4I7-1", "uniprot_id": "PRS45_MOUSE", "mass": 35723.0, "length": 317, "protein_name": "Inactive serine protease 45", "gene_name": "Prss45", "organism": "Mouse", "refseq_name": "inactive serine protease 45 precursor", "refseq_ac": "NP_694812", "gene_names_uniprotkb": "Prss45; Tessp5", "gene_names_refseq": "Prss45; Tespl; Tessp5", "protein_names_uniprotkb": "Inactive serine protease 45; Inactive testis serine protease 5; Trypsin-like protease p98", "protein_names_refseq": "inactive serine protease 45 precursor; inactive serine protease 45; inactive testis serine protease 5; protease, serine 45; trypsin-like protease p98", "tax_id": 10090, "disease": "", "pathway": " (mmu:260408)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20512923", "class_list": "", "function": "We identified a testis-specific protease-like protein tentatively named TESPL., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNK7;Q8K4D1", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K4I7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4L4-1", "uniprot_id": "POF1B_MOUSE", "mass": 67785.0, "length": 587, "protein_name": "Protein POF1B", "gene_name": "Pof1b", "organism": "Mouse", "refseq_name": "protein POF1B", "refseq_ac": "NP_853557", "gene_names_uniprotkb": "Pof1b", "gene_names_refseq": "2310066B14Rik; Pof1b", "protein_names_uniprotkb": "Protein POF1B", "protein_names_refseq": "protein POF1B", "tax_id": 10090, "disease": "primary ovarian insufficiency 2B (Disease Ontology:DOID:0080859)", "pathway": " (mmu:69693)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15459172;17123869;21952136;25428506;25428507;30084848;30779550;34428180", "class_list": "", "function": "Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development (By similarity)., [UniProtKB]; The data show that during mouse development Pof1b expression is activated in the external layers of the epidermis just prior to formation of the epidermal permeability barrier., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANY1;Q8C3A2;Q8R4R8", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005884 actin filament;GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0030057 desmosome", "go_biological_process": "GO:0007015 actin filament organization;GO:0030036 actin cytoskeleton organization;GO:0070830 bicellular tight junction assembly;GO:0003382 epithelial cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K4L4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VIF2-1", "uniprot_id": "PRS42_MOUSE", "mass": 36683.0, "length": 335, "protein_name": "Serine protease 42", "gene_name": "Prss42", "organism": "Mouse", "refseq_name": "serine protease 42 precursor", "refseq_ac": "NP_694739", "gene_names_uniprotkb": "Prss42; Tessp2", "gene_names_refseq": "Prss42; Tessp2", "protein_names_uniprotkb": "Serine protease 42; 3.4.21.-; Testis serine protease 2", "protein_names_refseq": "protease, serine 42; serine protease 42 precursor; testis serine protease 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:235628)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23536369;27111572;30379984", "class_list": "", "function": "Data therefore identified the direct interaction of a genomic region in the lncRNA-HSVIII locus with the Prss42/Tessp-2 promoter in spermatocytes, and suggested that sequences adjacent to the lncRNA function as enhancers for the Prss42/Tessp-2 gene., [RefSeq, PubMed]; Plays a role in spermatogenesis. Involved in germ cell survival during meiosis. Lacks protease activity in vitro., [UniProtKB, PubMed]; These results proposed a potential function of an lncRNA, Tesra, in transcriptional activation and suggest a novel relationship between an lncRNA and an enhancer., [RefSeq, PubMed]; These results strongly suggest that the three paralogous Prss/Tessp proteases play different roles in spermatogenesis and that Prss42/Tessp-2 and Prss43/Tessp-3 are required for germ cell survival during meiosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VIF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q96EQ9-1", "uniprot_id": "PRDM9_MOUSE", "mass": 97365.0, "length": 843, "protein_name": "Histone-lysine N-methyltransferase PRDM9", "gene_name": "Prdm9", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase PRDM9 isoform 2", "refseq_ac": "NP_001348365", "gene_names_uniprotkb": "Prdm9; Hst1; Meisetz", "gene_names_refseq": "Dsbc1; G1-419-29; Meisetz; PRDM9-B; Prdm9; Rcr1; repro7", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase PRDM9; 2.1.1.-; 2.1.1.354; 2.1.1.355; 2.1.1.359; 2.1.1.361; 2.1.1.362; Hybrid sterility protein 1; Meiosis-induced factor containing a PR/SET domain and zinc-finger motif; PR domain zinc finger protein 9; PR domain-containing protein 9; Protein-lysine N-methyltransferase PRDM9; [histone H3]-lysine36 N-trimethyltransferase PRDM9; [histone H3]-lysine4 N-trimethyltransferase PRDM9; [histone H3]-lysine9 N-trimethyltransferase PRDM9; [histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9; [histone H4]-lysine20 N-methyltransferase PRDM9", "protein_names_refseq": "PR domain zinc finger protein 9; PR domain-containing protein 9; VPR domain containing 9; [histone H3]-lysine36 N-trimethyltransferase PRDM9; [histone H3]-lysine4 N-trimethyltransferase PRDM9; [histone H3]-lysine9 N-trimethyltransferase PRDM9; [histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9; [histone H4]-lysine20 N-methyltransferase PRDM9; histone H3 lysine-4 methyltransferase; histone-lysine N-methyltransferase PRDM9 isoform 2; histone-lysine N-methyltransferase PRDM9; hybrid sterility protein 1; meiosis-induced factor containing a PR/SET domain and zinc-finger motif; protein-lysine N-methyltransferase PRDM9", "tax_id": 10090, "disease": "", "pathway": " (mmu:213389); (R-MMU-212436); (R-MMU-3214841)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "16292313;19074312;22028627;24095733;24785241;25894966;27362481;27932493;28126738;29478809;30365547;32001511;32374261;38217871", "class_list": "", "function": "Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination (PubMed:16292313, PubMed:24095733, PubMed:24785241, PubMed:27362481, PubMed:29478809, PubMed:32001511). Can also methylate all four core histones with H3 being the best substrate and the most highly modified (PubMed:24785241, PubMed:27362481). Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate (PubMed:24785241, PubMed:27362481). During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity (PubMed:22028627, PubMed:27362481, PubMed:29478809). Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression (PubMed:16292313, PubMed:29478809). During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema (PubMed:27932493). EWSR1 joins PRDM9 with the chromosomal axis through REC8 (PubMed:27932493). In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation (PubMed:16292313, PubMed:25894966). Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation (PubMed:16292313). In addition performs automethylation (PubMed:28126738). Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation (PubMed:27362481)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Mice in which the Meisetz gene is disrupted show sterility in both sexes due to severe impairment of the double-stranded break repair pathway, deficient pairing of homologous chromosomes and impaired sex body formation, [RefSeq, PubMed]; Natural variation in the zinc-finger-encoding exon of Prdm9 affects hybrid sterility phenotypes in mice., [RefSeq, PubMed]; Study identifies mammalian speciation gene, hybrid sterility 1 (Hst1) as Prdm9, encoding a histone H3 lysine 4 trimethyltransferase, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JJZ8;Q0D2N4", "ec_number_list": "2.1.1.355;2.1.1.-;2.1.1.364;2.1.1.359;2.1.1.354;2.1.1.361;2.1.1.372;2.1.1.362;2.1.1.367;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0043565 sequence-specific DNA binding;GO:0042800 histone H3K4 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q96EQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MW3-1", "uniprot_id": "PRAL1_MOUSE", "mass": 52402.0, "length": 458, "protein_name": "Preferentially expressed antigen in melanoma-like protein 1", "gene_name": "Pramel1", "organism": "Mouse", "refseq_name": "preferentially expressed antigen in melanoma-like protein 1", "refseq_ac": "NP_113554", "gene_names_uniprotkb": "Pramel1", "gene_names_refseq": "Pramel1", "protein_names_uniprotkb": "Preferentially expressed antigen in melanoma-like protein 1; Prame-like 1", "protein_names_refseq": "preferentially expressed antigen in melanoma-like 1; preferentially expressed antigen in melanoma-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:83491)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11279525;23565261;37781892", "class_list": "", "function": "May play a role in acrosome development and also in sperm maturation and motility., [UniProtKB, PubMed]; Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031514 motile cilium;GO:0001669 acrosomal vesicle;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99MW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR37-1", "uniprot_id": "PPDPF_MOUSE", "mass": 12260.0, "length": 115, "protein_name": "Pancreatic progenitor cell differentiation and proliferation factor", "gene_name": "Ppdpf", "organism": "Mouse", "refseq_name": "pancreatic progenitor cell differentiation and proliferation factor isoform a", "refseq_ac": "NP_079874", "gene_names_uniprotkb": "Ppdpf; Exdpf", "gene_names_refseq": "0610012G23Rik; 2610317A05Rik; 2700038C09Rik; 3110053G12Rik; Ppdpf", "protein_names_uniprotkb": "Pancreatic progenitor cell differentiation and proliferation factor; Exocrine differentiation and proliferation factor", "protein_names_refseq": "exocrine differentiation and proliferation factor; pancreatic progenitor cell differentiation and proliferation factor isoform a", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (mmu:66496)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "34031390;34428180;36453576;37027301", "class_list": "", "function": "PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1., [RefSeq, PubMed]; PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling. Publication Status: Online-Only, [RefSeq, PubMed]; PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1., [RefSeq, PubMed]; Probable regulator of exocrine pancreas development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58EU5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0001889 liver development;GO:0030154 cell differentiation;GO:0031929 TOR signaling;GO:0038202 TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CR37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CRB5-1", "uniprot_id": "PR7C1_MOUSE", "mass": 29258.0, "length": 251, "protein_name": "Prolactin-7C1", "gene_name": "Prl7c1", "organism": "Mouse", "refseq_name": "prolactin-7C1 isoform 1 precursor", "refseq_ac": "NP_080482", "gene_names_uniprotkb": "Prl7c1; Prlpo", "gene_names_refseq": "1600017N11Rik; Ghd20; PLP-O; Prl7c1; Prlpo; Prplo", "protein_names_uniprotkb": "Prolactin-7C1; PLP-O; PRL-like protein O; Placental prolactin-like protein O", "protein_names_refseq": "PRL-like protein O; growth hormone d20; placental prolactin-like protein O; prolactin-7C1 isoform 1 precursor; prolactin-7C1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67505)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12488360", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CRB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CS42-1", "uniprot_id": "PRPS2_MOUSE", "mass": 34786.0, "length": 318, "protein_name": "Ribose-phosphate pyrophosphokinase 2", "gene_name": "Prps2", "organism": "Mouse", "refseq_name": "ribose-phosphate pyrophosphokinase 2 isoform 1", "refseq_ac": "NP_001300687", "gene_names_uniprotkb": "Prps2", "gene_names_refseq": "2610101M19Rik; Prps-2; Prps2", "protein_names_uniprotkb": "Ribose-phosphate pyrophosphokinase 2; 2.7.6.1; PRS-II; Phosphoribosyl pyrophosphate synthase II", "protein_names_refseq": "PRS-II; phosphoribosyl pyrophosphate synthase II; phosphoribosyl pyrophosphate synthetase II; ribose-phosphate pyrophosphokinase 2 isoform 1; ribose-phosphate pyrophosphokinase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:110639); (R-MMU-73843)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;18250455;20484733;22872234;24855946;26004865;31219806;31736475;33300544;33649389;34203471;34428180;38952044;39627609", "class_list": "", "function": "Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis., [UniProtKB]; PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via the p53/Bcl-2/caspases signaling pathway., [RefSeq, PubMed]; PRPS2-mediated modulation of the antitumor immune response in lung cancer through CCL2-mediated tumor-associated macrophages and myeloid-derived suppressor cells., [RefSeq, PubMed]; Phosphoribosyl-pyrophosphate synthetase 2 (PRPS2) depletion regulates spermatogenic cell apoptosis and is correlated with hypospermatogenesis., [RefSeq, PubMed]; Study demonstrates with a Prps2 knockout mouse that the nexus between protein and nucleotide biosynthesis controlled by PRPS2 is crucial for Myc-driven tumorigenesis. Erratum:[Cell. 2014 Jul 31;158(3):689], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZA9", "ec_number_list": "2.7.6.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016208 AMP binding", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006098 pentose-phosphate shunt;GO:0006167 AMP biosynthetic process;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9CS42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D119-1", "uniprot_id": "PPR27_MOUSE", "mass": 17436.0, "length": 154, "protein_name": "Protein phosphatase 1 regulatory subunit 27", "gene_name": "Ppp1r27", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 27", "refseq_ac": "NP_081090", "gene_names_uniprotkb": "Ppp1r27; Dysfip1", "gene_names_refseq": "1110033I14Rik; Dysfip1; Ppp1r27; toonin", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 27; Dysferlin-interacting protein 1", "protein_names_refseq": "dysferlin-interacting protein 1; ortholog of human dysferlin interacting protein 1 (toonin) DYSFP1; protein phosphatase 1 regulatory subunit 27", "tax_id": 10090, "disease": "", "pathway": " (mmu:68701)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35820727", "class_list": "", "function": "Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ABX5", "ec_number_list": "", "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity;GO:0019902 phosphatase binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D119-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1G2-1", "uniprot_id": "PMVK_MOUSE", "mass": 21916.0, "length": 192, "protein_name": "Phosphomevalonate kinase", "gene_name": "Pmvk", "organism": "Mouse", "refseq_name": "phosphomevalonate kinase isoform 3", "refseq_ac": "NP_001297569", "gene_names_uniprotkb": "Pmvk", "gene_names_refseq": "1110011E12Rik; 2900002L22Rik; PMKASE; PMKA; PMK; Pmvk", "protein_names_uniprotkb": "Phosphomevalonate kinase; 2.7.4.2; PMKase", "protein_names_refseq": "phosphomevalonate kinase isoform 3", "tax_id": 10090, "disease": "porokeratosis (Disease Ontology:DOID:3805)", "pathway": " (mmu:68603); (R-MMU-9969896)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;26495903;34428180", "class_list": "", "function": "Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R021;Q9D6K3", "ec_number_list": "2.7.4.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0004631 phosphomevalonate kinase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0016126 sterol biosynthetic process;GO:0006695 cholesterol biosynthetic process;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D1G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB28-1", "uniprot_id": "POP5_MOUSE", "mass": 19285.0, "length": 169, "protein_name": "Ribonuclease P/MRP protein subunit POP5", "gene_name": "Pop5", "organism": "Mouse", "refseq_name": "ribonuclease P/MRP protein subunit POP5 isoform 1", "refseq_ac": "NP_080674", "gene_names_uniprotkb": "Pop5", "gene_names_refseq": "1500019J17Rik; 2700077E03Rik; Pop5; Rnasep3", "protein_names_uniprotkb": "Ribonuclease P/MRP protein subunit POP5", "protein_names_refseq": "ribonuclease P/MRP protein subunit POP5 isoform 1; ribonuclease P/MRP protein subunit POP5", "tax_id": 10090, "disease": "", "pathway": " (mmu:117109)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;34428180", "class_list": "", "function": "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CSC3;Q9CSL4", "ec_number_list": "", "go_molecular_function": "GO:0000171 ribonuclease MRP activity;GO:0004526 ribonuclease P activity;GO:0033204 ribonuclease P RNA binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DB28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESG9-1", "uniprot_id": "PMYT1_MOUSE", "mass": 54053.0, "length": 490, "protein_name": "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase", "gene_name": "Pkmyt1", "organism": "Mouse", "refseq_name": "membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1", "refseq_ac": "NP_075545", "gene_names_uniprotkb": "Pkmyt1; Myt1", "gene_names_refseq": "6230424P17; Myt1; Pkmyt1", "protein_names_uniprotkb": "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; 2.7.11.1; Myt1 kinase", "protein_names_refseq": "MYT1 kinase; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:268930); (R-MMU-156711); (R-MMU-69273); (R-MMU-69478)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "36988891", "class_list": "", "function": "Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect., [UniProtKB, UniProtKB]; ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNN2;Q8R3L4", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010972 negative regulation of G2/M transition of mitotic cell cycle;GO:0051321 meiotic cell cycle;GO:0110031 negative regulation of G2/MI transition of meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ESG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHK0-1", "uniprot_id": "PR2A1_MOUSE", "mass": 25554.0, "length": 228, "protein_name": "Prolactin-2A1", "gene_name": "Prl2a1", "organism": "Mouse", "refseq_name": "prolactin-2A1 precursor", "refseq_ac": "NP_064375", "gene_names_uniprotkb": "Prl2a1; Prlpm", "gene_names_refseq": "Ghd21; PLP-M; Prl2a1; Prlpm", "protein_names_uniprotkb": "Prolactin-2A1; PLP-M; PRL-like protein M; Placental prolactin-like protein M", "protein_names_refseq": "PRL-like protein M; growth hormone d21; placental prolactin-like protein M; prolactin-2A1 precursor; prolactin-2A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56635)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10471365;10856884;10906059;10922068;12885563;25428506", "class_list": "", "function": "Invading mouse trophoblast cells possess endocrine activities, including the expression of PLP-M., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI05", "ec_number_list": "", "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JHK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIG8-1", "uniprot_id": "PRAF2_MOUSE", "mass": 19478.0, "length": 178, "protein_name": "PRA1 family protein 2", "gene_name": "Praf2", "organism": "Mouse", "refseq_name": "PRA1 family protein 2", "refseq_ac": "NP_613068", "gene_names_uniprotkb": "Praf2; DXImx39e", "gene_names_refseq": "DXImx39e; JM4; Praf2; Sfc20", "protein_names_uniprotkb": "PRA1 family protein 2", "protein_names_refseq": "PRA1 family protein 2", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:54637)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10857745;26645984;33300544;34428180", "class_list": "", "function": "Consistent with its function of GB1 gatekeeper Prenylated Rab acceptor family, member 2 was present in brain areas expressing the GABAB, including the cortex, the hippocampus, the VTA and raphe nuclei., [RefSeq, PubMed]; May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0016020 membrane;GO:0098794 postsynapse;GO:0010008 endosome membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JIG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JK53-1", "uniprot_id": "PRELP_MOUSE", "mass": 43293.0, "length": 378, "protein_name": "Prolargin", "gene_name": "Prelp", "organism": "Mouse", "refseq_name": "prolargin precursor", "refseq_ac": "NP_473418", "gene_names_uniprotkb": "Prelp", "gene_names_refseq": "7330409J17Rik; Prelp; SLRR2A", "protein_names_uniprotkb": "Prolargin; Proline-arginine-rich end leucine-rich repeat protein", "protein_names_refseq": "prolargin precursor; prolargin; proline-arginine-rich end leucine-rich repeat protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:116847); (R-MMU-2022854); (R-MMU-2022857)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11731272;16452087;31599954;34428180;35788244;37507081;39369540;39927985", "class_list": "", "function": "Elevated PRELP expression in heart and liver fibrosis promotes collagen production., [RefSeq, PubMed]; Expressed in cartilage throughout both fetal development and post-natal life, [RefSeq, PubMed]; May anchor basement membranes to the underlying connective tissue., [UniProtKB, UniProtKB]; PRELP promotes myocardial fibrosis and ventricular remodelling after acute myocardial infarction by the wnt/beta-catenin signalling pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0090398 cellular senescence", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9JK53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QUN5-1", "uniprot_id": "PR3C1_MOUSE", "mass": 24706.0, "length": 212, "protein_name": "Prolactin-3C1", "gene_name": "Prl3c1", "organism": "Mouse", "refseq_name": "prolactin-3C1 isoform 2", "refseq_ac": "NP_001156690", "gene_names_uniprotkb": "Prl3c1; Prlpi; Prlpj", "gene_names_refseq": "Ghd7; PLP-I; PLP-J; Prl3c1; Prlpi; Prlpj; decidualin", "protein_names_uniprotkb": "Prolactin-3C1; Decidualin; PLP-I; PLP-J; PRL-like protein I; PRL-like protein J; Placental prolactin-like protein J; Prolactin-like protein I", "protein_names_refseq": "PLP I; PRL-like protein I; PRL-like protein J; growth hormone d7; placental prolactin-like protein J; prolactin-3C1 isoform 2; prolactin-3C1; prolactin-like protein I", "tax_id": 10090, "disease": "hyperandrogenism (Disease Ontology:DOID:11613)", "pathway": " (mmu:27372)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10537137;10542329;10856884;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SZY4", "ec_number_list": "", "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QUN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZH3-1", "uniprot_id": "PPIE_MOUSE", "mass": 33449.0, "length": 301, "protein_name": "Peptidyl-prolyl cis-trans isomerase E", "gene_name": "Ppie", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase E", "refseq_ac": "NP_062362", "gene_names_uniprotkb": "Ppie; Cyp33", "gene_names_refseq": "2010010D16Rik; Cyp33; Ppie", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase E; 5.2.1.8; Cyclophilin E; Cyclophilin-33; PPIase E; Rotamase E", "protein_names_refseq": "PPIase E; cyclophilin-33; peptidyl-prolyl cis-trans isomerase E; rotamase E", "tax_id": 10090, "disease": "", "pathway": " (mmu:56031); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6798695); (R-MMU-72163)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;30059200;31219806;34428180", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8C0", "ec_number_list": "3.6.4.13;5.2.1.8;2.4.1.25;3.2.1.33;3.6.4.-;3.5.4.6;1.11.1.24;5.6.2.3;3.4.22.52;3.4.19.12;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;5.3.1.9;5.1.3.-;3.6.4.10;2.4.2.7;3.1.13.-;2.7.7.48;2.7.7.6;1.16.3.1;3.6.5.-;4.2.1.24;3.4.22.1;3.2.1.31;2.7.1.11;2.7.10.2;3.4.23.5;2.5.1.18;4.2.99.18;5.6.2.4;2.4.2.1;3.2.1.23;1.11.1.6;3.3.2.6;3.4.11.4;1.1.1.205;5.3.2.1;5.3.3.12;3.1.-.-;6.5.1.1;3.4.24.35;3.6.1.-;2.7.11.24;1.13.11.-;1.13.11.34;1.11.1.7;3.1.6.12;2.7.7.7;3.1.11.-;2.7.11.1;2.7.1.40;3.5.4.5;2.3.2.27;2.3.2.32;3.4.25.1;2.7.11.39;2.7.4.6;2.7.13.3;3.6.4.6;2.7.11.22;2.7.11.23;2.7.1.1;2.7.1.-;3.1.1.47;2.3.2.26;5.4.2.2;5.4.2.7;3.1.6.14;2.7.1.35;3.4.19.1;3.6.1.6;2.3.3.8;4.1.2.4;2.3.2.5;5.4.2.11;5.4.2.4;2.4.1.1;2.4.1.186;3.4.18.1;3.5.1.23;3.5.1.-", "go_molecular_function": "GO:0003729 mRNA binding;GO:0016018 cyclosporin A binding;GO:0008143 poly(A) binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006457 protein folding;GO:0000398 mRNA splicing, via spliceosome;GO:0045070 positive regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QZH3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1P1-1", "uniprot_id": "PSB3_MOUSE", "mass": 22965.0, "length": 205, "protein_name": "Proteasome subunit beta type-3", "gene_name": "Psmb3", "organism": "Mouse", "refseq_name": "proteasome subunit beta type-3", "refseq_ac": "NP_036101", "gene_names_uniprotkb": "Psmb3", "gene_names_refseq": "C10-II; Psmb3", "protein_names_uniprotkb": "Proteasome subunit beta type-3; Proteasome chain 13; Proteasome component C10-II; Proteasome subunit beta-3; Proteasome theta chain; beta-3", "protein_names_refseq": "beta-3; proteasome chain 13; proteasome component C10-II; proteasome subunit beta type-3; proteasome subunit beta-3; proteasome theta chain", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:26446); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 58, "publication_count": 14, "publication_id_list": "10436176;12438746;16581775;16857966;18250455;22341445;23806337;28011936;31219806;33725478;34428180;35984892;37507081;37828378", "class_list": "", "function": "Located within a 185-kb contig surrounding a transgene on chromosome 11, [RefSeq, PubMed]; Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0030163 protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9R1P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z2E4-1", "uniprot_id": "PPR17_MOUSE", "mass": 17815.0, "length": 159, "protein_name": "Protein phosphatase 1 regulatory subunit 17", "gene_name": "Ppp1r17", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 17", "refseq_ac": "NP_035283", "gene_names_uniprotkb": "Ppp1r17; Gsbs", "gene_names_refseq": "Gsbs; Ppp1r17; Ppp1r2", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 17; G substrate", "protein_names_refseq": "G substrate; protein phosphatase 1 regulatory subunit 17; protein phosphatase 1, regulatory (inhibitor) 2", "tax_id": 10090, "disease": "familial hypercholesterolemia (Disease Ontology:DOID:13810)", "pathway": " (mmu:19051)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12213562;15857669;37572185;38194970;9920894", "class_list": "", "function": "DMH[Ppp1r17] neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication., [RefSeq, PubMed]; Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes., [UniProtKB, PubMed]; PPARdelta dysregulation of CCL20/CCR6 axis promotes gastric adenocarcinoma carcinogenesis by remodeling gastric tumor microenvironment., [RefSeq, PubMed]; Retinal G-substrate plays a role as a downstream component of the NO-cGMP-PKG pathway. The co-localization of retinal G-substrate with protein Ser/Thr phosphatases suggests that it acts as an endogenous protein phosphatase inhibitor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0019212 phosphatase inhibitor activity;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0010921 regulation of phosphatase activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z2E4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62835-1", "uniprot_id": "RAP1A_MOUSE", "mass": 20987.0, "length": 184, "protein_name": "Ras-related protein Rap-1A", "gene_name": "Rap1a", "organism": "Mouse", "refseq_name": "ras-related protein Rap-1A", "refseq_ac": "NP_663516", "gene_names_uniprotkb": "Rap1a; Krev-1", "gene_names_refseq": "G-22K; Krev-1; Rap1a; Rap1", "protein_names_uniprotkb": "Ras-related protein Rap-1A; 3.6.5.2; Ras-related protein Krev-1", "protein_names_refseq": "GTP-binding protein SMG-P21A; RAS-related protein 1a; ras-related protein Krev-1; ras-related protein Rap-1A", "tax_id": 10090, "disease": "", "pathway": " (mmu:109905); (R-MMU-170968); (R-MMU-170984); (R-MMU-354192); (R-MMU-354194); (R-MMU-372708); (R-MMU-381676); (R-MMU-392517); (R-MMU-5674135); (R-MMU-6798695); (R-MMU-8875555)", "pathway_count": 11, "publication_count": 8, "publication_id_list": "19635461;21750661;28528544;33300544;37507081;37828378;39269448;39324266", "class_list": "", "function": "Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (By similarity). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions., [UniProtKB, PubMed, UniProtKB]; PH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A., [RefSeq, PubMed]; Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and Permeability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P10113", "ec_number_list": "3.6.5.-;2.3.2.27;7.6.2.1;3.1.3.48;3.6.5.2;3.6.5.3;1.14.19.17;5.2.1.-;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;3.4.24.81;3.6.1.5;2.7.11.1;1.14.14.18;2.7.10.2;3.4.21.73;3.6.5.4;2.7.10.1;2.7.12.2;3.6.5.5;2.7.10.4;3.6.4.-;1.1.1.-;2.7.11.24;3.6.1.-;3.4.24.-;3.6.1.15;2.3.1.78;1.6.3.-;3.2.2.6;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;3.6.-.-;2.3.1.51;3.1.4.4;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:2000301 negative regulation of synaptic vesicle exocytosis;GO:0061028 establishment of endothelial barrier;GO:0032486 Rap protein signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P62835-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08556-1", "uniprot_id": "RASN_MOUSE", "mass": 21199.0, "length": 189, "protein_name": "GTPase NRas", "gene_name": "Nras", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nras", "gene_names_refseq": "", "protein_names_uniprotkb": "GTPase NRas; 3.6.5.2; Transforming protein N-Ras", "protein_names_refseq": "", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myelodysplastic syndrome (Disease Ontology:DOID:0050908); Noonan syndrome 3 (Disease Ontology:DOID:0060581); Noonan syndrome 6 (Disease Ontology:DOID:0060584); RASopathy (Disease Ontology:DOID:0080690); autoimmune lymphoproliferative syndrome type 4 (Disease Ontology:DOID:0110117); epidermal nevus (Disease Ontology:DOID:0111162); large congenital melanocytic nevus (Disease Ontology:DOID:0111359); linear nevus sebaceous syndrome (Disease Ontology:DOID:0111530); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leukemia (Disease Ontology:DOID:1240); cancer (Disease Ontology:DOID:162); melanoma (Disease Ontology:DOID:1909); kidney cancer (Disease Ontology:DOID:263); transitional cell carcinoma (Disease Ontology:DOID:2671); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); papillary thyroid carcinoma (Disease Ontology:DOID:3969); cervical cancer (Disease Ontology:DOID:4362); hepatocellular carcinoma (Disease Ontology:DOID:684); liver carcinoma (Disease Ontology:DOID:686); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); cholangitis (Disease Ontology:DOID:9446); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (R-MMU-1169092); (R-MMU-1250347); (R-MMU-1433557); (R-MMU-171007); (R-MMU-179812); (R-MMU-180336); (R-MMU-186763); (R-MMU-1963640); (R-MMU-210993); (R-MMU-2179392); (R-MMU-2424491); (R-MMU-2871796); (R-MMU-375165); (R-MMU-5218921); (R-MMU-5621575); (R-MMU-5654688); (R-MMU-5654693); (R-MMU-5654699); (R-MMU-5654700); (R-MMU-5654704); (R-MMU-5654706); (R-MMU-5654712); (R-MMU-5654719); (R-MMU-5658442); (R-MMU-5673000); (R-MMU-5673001); (R-MMU-5674135); (R-MMU-5675221); (R-MMU-6798695); (R-MMU-8849471); (R-MMU-8851805); (R-MMU-9607240); (R-MMU-9634635); (R-MMU-9648002)", "pathway_count": 34, "publication_count": 7, "publication_id_list": "21750661;26495903;2835730;33300544;34428180;37507081;3865197", "class_list": "", "function": "Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (By similarity). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 30, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;2.3.2.27;7.6.2.1;3.1.3.48;3.6.5.2;3.6.5.3;3.2.1.31;3.4.24.81;3.6.1.5;2.7.11.1;2.7.10.2;2.7.10.1;3.4.21.73;2.7.11.17;3.6.5.4;2.7.12.2;3.6.5.5;2.7.10.4;2.7.1.153;2.7.1.137;3.4.26.1;2.3.1.225;3.6.4.-;1.1.1.-;3.1.3.16;2.7.11.24;3.2.1.20;3.1.2.22;3.1.2.-;3.6.1.-;2.7.11.13;3.4.24.-;3.6.1.15;2.3.1.78;1.6.3.-;2.5.1.58;2.5.1.59;2.7.11.25;3.6.-.-;2.7.1.91;2.3.1.-;2.1.1.100;3.1.4.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0045766 positive regulation of angiogenesis;GO:0050852 T cell receptor signaling pathway;GO:0007265 Ras protein signal transduction;GO:0001938 positive regulation of endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P08556-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83861-1", "uniprot_id": "QRFPR_MOUSE", "mass": 49245.0, "length": 433, "protein_name": "Pyroglutamylated RF-amide peptide receptor", "gene_name": "Qrfpr", "organism": "Mouse", "refseq_name": "pyroglutamylated RF-amide peptide receptor", "refseq_ac": "NP_937835", "gene_names_uniprotkb": "Qrfpr; Gpr103", "gene_names_refseq": "AQ27; Gpr103a; Gpr103; Qrfpr; SP9155", "protein_names_uniprotkb": "Pyroglutamylated RF-amide peptide receptor; AQ27; G protein-coupled receptor 103; Orexigenic neuropeptide QRFP receptor; SP9155", "protein_names_refseq": "G protein-coupled receptor 103; QRFP receptor; orexigenic neuropeptide QRFP receptor; pyroglutamylated RF-amide peptide receptor", "tax_id": 10090, "disease": "bone structure disease (Disease Ontology:DOID:0080010)", "pathway": " (mmu:229214); (R-MMU-389397); (R-MMU-416476)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12714592;12960173;16382160;16648250;20534693;21750661;27224020;30219516;36251705", "class_list": "", "function": "Characterization and tissue distribution of SP9155 (GPR103) ligand [GPR103/SP9155], [RefSeq, PubMed]; Ontogeny of QRFP and its receptor expression in mouse testis during post-natal development, [RefSeq, PubMed]; Osteopenia in GPR103-/- mice may be mediated directly by the loss of GPR103 expression in bone., [RefSeq, PubMed]; QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome, [RefSeq, PubMed]; Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels (By similarity)., [UniProtKB, UniProtKB]; Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis., [RefSeq, PubMed]; The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors. Publication Status: Online-Only, [RefSeq, PubMed]; We treated mice with the synthetic GPR103 receptor agonist peptide P550 and the anxious behavior was investigated using an elevated plus-maze test., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004983 neuropeptide Y receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0097730 non-motile cilium;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P83861-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JI6-1", "uniprot_id": "RAP1B_MOUSE", "mass": 20825.0, "length": 184, "protein_name": "Ras-related protein Rap-1b", "gene_name": "Rap1b", "organism": "Mouse", "refseq_name": "ras-related protein Rap-1b", "refseq_ac": "NP_077777", "gene_names_uniprotkb": "Rap1b", "gene_names_refseq": "2810443E11Rik; Rap1b", "protein_names_uniprotkb": "Ras-related protein Rap-1b; 3.6.5.2; GTP-binding protein smg p21B", "protein_names_refseq": "GTP-binding protein smg p21B; ras-related protein Rap-1b", "tax_id": 10090, "disease": "thrombocytopenia (Disease Ontology:DOID:1588)", "pathway": " (mmu:215449); (R-MMU-354192); (R-MMU-354194); (R-MMU-372708); (R-MMU-392517); (R-MMU-5674135); (R-MMU-6798695); (R-MMU-8875555)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "1555775;21750661;33300544;38010922", "class_list": "", "function": "GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity)., [UniProtKB, UniProtKB]; Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;2.7.11.1;2.7.10.2;3.6.5.4;2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;2.7.10.1;2.7.12.2;3.1.3.48;3.6.5.5;2.7.10.4;3.4.23.-;3.6.4.-;2.7.11.24;3.2.1.20;7.6.2.1;3.6.1.-;3.6.1.15;2.3.1.51;2.3.1.23;2.3.1.67;2.3.1.25;7.6.2.-;3.4.16.2;3.6.-.-;3.1.3.5;3.1.3.2;3.2.1.25;2.5.1.18;3.5.1.92", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:2000301 negative regulation of synaptic vesicle exocytosis;GO:0061028 establishment of endothelial barrier;GO:0032486 Rap protein signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99JI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NXW6-1", "uniprot_id": "RAD17_MOUSE", "mass": 77391.0, "length": 688, "protein_name": "Cell cycle checkpoint protein RAD17", "gene_name": "Rad17", "organism": "Mouse", "refseq_name": "cell cycle checkpoint protein RAD17 isoform 1", "refseq_ac": "NP_001037836", "gene_names_uniprotkb": "Rad17", "gene_names_refseq": "MmRad24; Rad17", "protein_names_uniprotkb": "Cell cycle checkpoint protein RAD17", "protein_names_refseq": "RAD17 homolog; cell cycle checkpoint protein RAD17 isoform 1; cell cycle checkpoint protein RAD17", "tax_id": 10090, "disease": "", "pathway": " (mmu:19356); (R-MMU-176187); (R-MMU-5685938); (R-MMU-5693607); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10232579;10480350;11687627;14500819;15297881;17376776;21750661;9933569", "class_list": "", "function": "Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (By similarity). Has a weak ATPase activity required for binding to chromatin (By similarity). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (By similarity). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (By similarity). May also serve as a sensor of DNA replication progression (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88934;O89024", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0003689 DNA clamp loader activity;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0035861 site of double-strand break", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0042325 regulation of phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6NXW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZT8-1", "uniprot_id": "RAB3B_MOUSE", "mass": 24757.0, "length": 219, "protein_name": "Ras-related protein Rab-3B", "gene_name": "Rab3b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-3B", "refseq_ac": "NP_076026", "gene_names_uniprotkb": "Rab3b", "gene_names_refseq": "2610528C18Rik; Rab3b", "protein_names_uniprotkb": "Ras-related protein Rab-3B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-3B", "tax_id": 10090, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:69908); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12578829;17114649;18396146;18849981;21750661;29125462", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9536, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80WV9;Q920F1", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;2.5.1.60;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0030742 GTP-dependent protein binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission;GO:0015031 protein transport;GO:0097494 regulation of vesicle size;GO:0006887 exocytosis;GO:0018125 peptidyl-cysteine methylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CZT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B8ZXI1-1", "uniprot_id": "QTRT2_MOUSE", "mass": 46288.0, "length": 415, "protein_name": "Queuine tRNA-ribosyltransferase accessory subunit 2", "gene_name": "Qtrt2", "organism": "Mouse", "refseq_name": "queuine tRNA-ribosyltransferase accessory subunit 2 isoform 1", "refseq_ac": "NP_001343258", "gene_names_uniprotkb": "Qtrt2; QTRT2; Qtrtd1", "gene_names_refseq": "3110012M05Rik; 4930470H18Rik; Qrtr2; Qtrt2; Qtrtd1", "protein_names_uniprotkb": "Queuine tRNA-ribosyltransferase accessory subunit 2; Queuine tRNA-ribosyltransferase domain-containing protein 1", "protein_names_refseq": "queuine tRNA-ribosyltransferase accessory subunit 2 isoform 1; queuine tRNA-ribosyltransferase domain containing 1; queuine tRNA-ribosyltransferase domain-containing protein 1; queuine tRNA-ribosyltransferase subunit QTRTD1", "tax_id": 10090, "disease": "", "pathway": " (mmu:106248)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19414587;21750661;29862811;35815944", "class_list": "", "function": "In the crystal, QTRT2 is clearly present as a homodimer that is strikingly similar to that formed by bacterial TGT. In particular, a cluster of four aromatic residues within the interface of the bacterial TGT, which constitutes a 'hot spot' for dimer stability, is present in a similar constellation in QTRT2., [RefSeq, PubMed]; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)., [UniProtKB, HAMAP, PubMed, PubMed, UniProtKB, UniProtKB]; Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase., [RefSeq, PubMed]; TGT weakly interacts with the outer mitochondrial membrane possibly through association with Qv1(QTRD1 variant 1), which was found to be stably associated with the organelle, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9C446;Q5XK35", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000049 tRNA binding;GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity", "go_cellular_component": "GO:1990234 transferase complex;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0032991 protein-containing complex;GO:0032473 cytoplasmic side of mitochondrial outer membrane", "go_biological_process": "GO:0006400 tRNA modification;GO:0002099 tRNA wobble guanine modification", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B8ZXI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08989-1", "uniprot_id": "RASM_MOUSE", "mass": 23901.0, "length": 208, "protein_name": "Ras-related protein M-Ras", "gene_name": "Mras", "organism": "Mouse", "refseq_name": "ras-related protein M-Ras", "refseq_ac": "NP_032650", "gene_names_uniprotkb": "Mras; Xras", "gene_names_refseq": "2900078C09Rik; Mras", "protein_names_uniprotkb": "Ras-related protein M-Ras; 3.6.5.2; Muscle and microspikes Ras; Ras-related protein R-Ras3; X-Ras", "protein_names_refseq": "X-Ras; ras-related protein M-Ras; ras-related protein R-Ras3", "tax_id": 10090, "disease": "Noonan syndrome 11 (Disease Ontology:DOID:0112169)", "pathway": " (mmu:17532); (R-MMU-5673000)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10477695;11313946;21750661;9395237", "class_list": "", "function": "Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (By similarity). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). The formation of the SMP complex only occurs when MRAS is GTP-bound (By similarity). MRAS has low intrinsic GTPase activity and may require additional factors for activation (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;2.7.11.1;3.6.5.4;3.6.5.5;3.1.3.53;3.1.3.16;3.6.1.-;3.6.1.15;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030742 GTP-dependent protein binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0007265 Ras protein signal transduction;GO:0007163 establishment or maintenance of cell polarity;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O08989-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTZ1-1", "uniprot_id": "RBX2_MOUSE", "mass": 12707.0, "length": 113, "protein_name": "RING-box protein 2", "gene_name": "Rnf7", "organism": "Mouse", "refseq_name": "RING-box protein 2 isoform 2", "refseq_ac": "NP_001298064", "gene_names_uniprotkb": "Rnf7; Rbx2; Sag", "gene_names_refseq": "Rbx2; Rnf7; SAG", "protein_names_uniprotkb": "RING-box protein 2; 2.3.2.27; 2.3.2.32; RING finger protein 7; Rbx2; Sensitive to apoptosis gene protein", "protein_names_refseq": "RING-box protein 2 isoform 2; RING-box protein 2; sensitive to apoptosis gene protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:19823); (R-MMU-8951664); (R-MMU-9705462); (R-MMU-983168)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10082581;21750661;22110742;22118770;24210661;29361558;32513959;34428180;36745565;38873758", "class_list": "", "function": "Catalytic component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:22118770, PubMed:24210661, PubMed:29361558). It is thereby involved in various biological processes, such as cell cycle progression, signal transduction and transcription (PubMed:22118770, PubMed:24210661, PubMed:29361558). The functional specificity of the E3 ubiquitin-protein ligase ECS complexes depend on the variable SOCS box-containing substrate recognition component (PubMed:24210661). Within ECS complexes, RNF7/RBX2 recruits the E2 ubiquitination enzyme to the complex via its RING-type and brings it into close proximity to the substrate (By similarity). Catalytic subunit of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1 (PubMed:24210661, PubMed:29361558). The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR (By similarity). Promotes ubiquitination and degradation of NF1, thereby regulating Ras protein signal transduction (PubMed:22118770). As part of the ECS(ASB9) complex, catalyzes ubiquitination and degradation of CKB (By similarity). The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS (By similarity). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (By similarity). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (By similarity). As part of some ECS complex, catalyzes 'Lys-11'-linked ubiquitination and degradation of BTRC (By similarity). ECS complexes and ARIH2 collaborate in tandem to mediate ubiquitination of target proteins; ARIH2 mediating addition of the first ubiquitin on CRLs targets (By similarity). As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism (By similarity). Specifically catalyzes the neddylation of CUL5 via its interaction with UBE2F (By similarity). Does not catalyze neddylation of other cullins (CUL1, CUL2, CUL3, CUL4A or CUL4B) (By similarity). May play a role in protecting cells from apoptosis induced by redox agents (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Sag/Rbx2 Partial Inactivation Sensitizes Mice to Radiation and Radiation-Induced Tumorigenesis1., [RefSeq, PubMed]; Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKF8", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;3.4.-.-;2.7.10.2;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0097602 cullin family protein binding;GO:0061663 NEDD8 ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031466 Cul5-RING ubiquitin ligase complex", "go_biological_process": "GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:0021799 cerebral cortex radially oriented cell migration;GO:0046314 phosphocreatine biosynthetic process;GO:0043066 negative regulation of apoptotic process;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WTZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z4I3-1", "uniprot_id": "RBM24_MOUSE", "mass": 24822.0, "length": 236, "protein_name": "RNA-binding protein 24", "gene_name": "Rbm24", "organism": "Mouse", "refseq_name": "RNA-binding protein 24", "refseq_ac": "NP_001074894", "gene_names_uniprotkb": "Rbm24", "gene_names_refseq": "6330546B05Rik; Rbm24", "protein_names_uniprotkb": "RNA-binding protein 24; RNA-binding motif protein 24", "protein_names_refseq": "RNA-binding protein 24", "tax_id": 10090, "disease": "microphthalmia (Disease Ontology:DOID:10629); dilated cardiomyopathy (Disease Ontology:DOID:12930); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:666794)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "19658189;20977548;24375645;25217815;25313962;26844700;26990106;29358667;34428180;36947695;38483314;39113792", "class_list": "", "function": "Deciphering the genetic interactions between Pou4f3, Gfi1, and Rbm24 in maintaining mouse cochlear hair cell survival. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:25313962, PubMed:26844700). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:25313962, PubMed:26844700). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:25313962, PubMed:26844700). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (PubMed:25313962). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability. Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities. Involved in myogenic differentiation by regulating MYOG levels. Binds to multiple regions in the mRNA 3'-UTR of TP63, hence inducing its destabilization. Also promotes the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence. Plays a role in the regulation of mRNA translation. Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation. Binds to a huge amount of mRNAs (By similarity). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (PubMed:25313962, PubMed:29358667). Together with RBM20, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; RBM24 is required for mouse hair cell development through regulating pre-mRNA alternative splicing and mRNA stability., [RefSeq, PubMed]; Rbm24 plays a crucial role in myogenic differentiation at least in part through a myogenin-dependent post-transcriptional regulatory pathway., [RefSeq, PubMed]; Rbm24/Notch1 signaling regulates adult neurogenesis in the subventricular zone and mediates Parkinson-associated olfactory dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; Study suggests that p63 is regulated by RBM24 via mRNA stability, which gives an insight into understanding how posttranscriptional regulatory mechanisms contribute to p63 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0097157 pre-mRNA intronic binding;GO:0003730 mRNA 3'-UTR binding;GO:1990715 mRNA CDS binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0010830 regulation of myotube differentiation;GO:0006397 mRNA processing;GO:0030154 cell differentiation;GO:0048255 mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "D3Z4I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z268-1", "uniprot_id": "RASL1_MOUSE", "mass": 89395.0, "length": 799, "protein_name": "RasGAP-activating-like protein 1", "gene_name": "Rasal1", "organism": "Mouse", "refseq_name": "rasGAP-activating-like protein 1 isoform 1", "refseq_ac": "NP_038860", "gene_names_uniprotkb": "Rasal1; Rasal", "gene_names_refseq": "MRASAL; Rasal1", "protein_names_uniprotkb": "RasGAP-activating-like protein 1; RAS protein activator like 1; Ras GTPase-activating-like protein", "protein_names_refseq": "ras GTPase-activating-like protein; rasGAP-activating-like protein 1 isoform 1; rasGAP-activating-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19415); (R-MMU-5658442)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;31641113;40684658;9751798", "class_list": "", "function": "Probable inhibitory regulator of the Ras-cyclic AMP pathway. Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB]; ZAP-70-associated Rasal1 as a new negative regulator of T-cell activation and tumor immunity.Rasal1 binds to the kinase domain of ZAP-70. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q99K69", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0046580 negative regulation of Ras protein signal transduction;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z268-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BSI6-1", "uniprot_id": "R3HC1_MOUSE", "mass": 54163.0, "length": 488, "protein_name": "R3H and coiled-coil domain-containing protein 1", "gene_name": "R3hcc1", "organism": "Mouse", "refseq_name": "R3H and coiled-coil domain-containing protein 1 isoform b", "refseq_ac": "NP_001139484", "gene_names_uniprotkb": "R3hcc1", "gene_names_refseq": "1700020M16Rik; R3hcc1", "protein_names_uniprotkb": "R3H and coiled-coil domain-containing protein 1", "protein_names_refseq": "R3H and coiled-coil domain-containing protein 1 isoform b; R3H and coiled-coil domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71843)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;22927429", "class_list": "", "function": "Ribosome profiling indicates that this gene can use a non-AUG (CUG) start codon in both human HEK293 and mouse embryonic fibroblast cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BSI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08AT1-1", "uniprot_id": "RASLC_MOUSE", "mass": 29555.0, "length": 266, "protein_name": "Ras-like protein family member 12", "gene_name": "Rasl12", "organism": "Mouse", "refseq_name": "ras-like protein family member 12 isoform 1", "refseq_ac": "NP_001028330", "gene_names_uniprotkb": "Rasl12", "gene_names_refseq": "4631404I11Rik; Rasl12", "protein_names_uniprotkb": "Ras-like protein family member 12; 3.6.5.2", "protein_names_refseq": "ras-like protein family member 12 isoform 1; ras-like protein family member 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:70784)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAU9", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08AT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC70-1", "uniprot_id": "RBMS2_MOUSE", "mass": 40724.0, "length": 383, "protein_name": "RNA-binding motif, single-stranded-interacting protein 2", "gene_name": "Rbms2", "organism": "Mouse", "refseq_name": "RNA-binding motif, single-stranded-interacting protein 2 isoform b", "refseq_ac": "NP_001034169", "gene_names_uniprotkb": "Rbms2", "gene_names_refseq": "2610315E04Rik; Rbms2; Scr3", "protein_names_uniprotkb": "RNA-binding motif, single-stranded-interacting protein 2", "protein_names_refseq": "RNA-binding motif, single-stranded-interacting protein 2 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:56516)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22198336;25428506;31219806;34428180", "class_list": "", "function": "SRC-3 protein is a significant regulator of infection and inflammation, and SRC-3 protein play an essential role in the development of immunosuppression accompanied with SIRS(systemic inflammatory response syndrome)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VC70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGC6-1", "uniprot_id": "RBM28_MOUSE", "mass": 84214.0, "length": 750, "protein_name": "RNA-binding protein 28", "gene_name": "Rbm28", "organism": "Mouse", "refseq_name": "RNA-binding protein 28", "refseq_ac": "NP_598686", "gene_names_uniprotkb": "Rbm28", "gene_names_refseq": "2810480G15Rik; Rbm28", "protein_names_uniprotkb": "RNA-binding protein 28; RNA-binding motif protein 28", "protein_names_refseq": "RNA-binding protein 28", "tax_id": 10090, "disease": "alopecia, neurologic defects, and endocrinopathy syndrome (Disease Ontology:DOID:0112244)", "pathway": " (mmu:68272)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;21750661;31219806;34428180", "class_list": "", "function": "Nucleolar component of the spliceosomal ribonucleoprotein complexes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKF8;Q3U0K5;Q8BG25;Q8VEJ8;Q9CS22;Q9CSE6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CGC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YT9-1", "uniprot_id": "RBM11_MOUSE", "mass": 26945.0, "length": 238, "protein_name": "Splicing regulator RBM11", "gene_name": "Rbm11", "organism": "Mouse", "refseq_name": "splicing regulator RBM11 isoform 1", "refseq_ac": "NP_938044", "gene_names_uniprotkb": "Rbm11", "gene_names_refseq": "A330018F01; Rbm11", "protein_names_uniprotkb": "Splicing regulator RBM11; RNA-binding motif protein 11", "protein_names_refseq": "putative RNA-binding protein 11; splicing regulator RBM11 isoform 1; splicing regulator RBM11", "tax_id": 10090, "disease": "", "pathway": " (mmu:224344)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;21984414", "class_list": "", "function": "Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z0X9;Q8BYK1", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003727 single-stranded RNA binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0030154 cell differentiation;GO:0008380 RNA splicing;GO:0034599 cellular response to oxidative stress;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80YT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35551-1", "uniprot_id": "RABE1_MOUSE", "mass": 99524.0, "length": 862, "protein_name": "Rab GTPase-binding effector protein 1", "gene_name": "Rabep1", "organism": "Mouse", "refseq_name": "rab GTPase-binding effector protein 1 isoform 2", "refseq_ac": "NP_001278070", "gene_names_uniprotkb": "Rabep1; Rab5ep; Rabpt5a; Rabpt5", "gene_names_refseq": "Rab5ep; Rabep1; rabaptin-5alpha; rabaptin-5", "protein_names_uniprotkb": "Rab GTPase-binding effector protein 1; Rabaptin-5alpha; Rabaptin-5", "protein_names_refseq": "RAB5 effector protein; neurocrescin; rab GTPase-binding effector protein 1 isoform 2; rab GTPase-binding effector protein 1; rabaptin 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:54189)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11977240;17242355;21183079;21750661;22841712;25405894;26495903;29400714;30084848;30779550;31219806;33339852;34428180;9427343", "class_list": "", "function": "Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Forms a complex with RABGEF1 that stimulates RABGEF1-mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Restoring C9ORF72 levels or augmenting its function with constitutively active RAB5 or chemical modulators of RAB5 effectors rescued patient neuron survival and ameliorated neurodegenerative processes in both gain- and loss-of-function C9ORF72 mouse models, [RefSeq, PubMed]; The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1L322;Q5QNU3;Q99L08;Q9CRP3;Q9EQF9;Q9JI94", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0006915 apoptotic process;GO:0016192 vesicle-mediated transport;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O35551-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88851-1", "uniprot_id": "RBBP9_MOUSE", "mass": 20912.0, "length": 186, "protein_name": "Serine hydrolase RBBP9", "gene_name": "Rbbp9", "organism": "Mouse", "refseq_name": "serine hydrolase RBBP9", "refseq_ac": "NP_056569", "gene_names_uniprotkb": "Rbbp9; Bog", "gene_names_refseq": "Bog; Rbbp9", "protein_names_uniprotkb": "Serine hydrolase RBBP9; 3.1.-.-; B5T-overexpressed gene protein; Protein BOG; RBBP-9; Retinoblastoma-binding protein 9", "protein_names_refseq": "B5T-overexpressed gene protein; RBBP-9; putative hydrolase RBBP9; retinoblastoma-binding protein 9; serine hydrolase RBBP9", "tax_id": 10090, "disease": "", "pathway": " (mmu:26450)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16272168;32484881", "class_list": "", "function": "First report of very pronounced and producible sex differences in expresion of RBBP9; RBBP9 expression inversely correlated with RB phosphorylation, [RefSeq, PubMed]; Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2., [RefSeq, PubMed]; Serine hydrolase. Catalyzes the hydrolytic activation of amino acid ester of the antiviral prodrug valacyclovir to its corresponding active drug, acyclovir. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYJ9", "ec_number_list": "3.1.-.-", "go_molecular_function": "GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0042127 regulation of cell population proliferation;GO:0006805 xenobiotic metabolic process;GO:0060510 type II pneumocyte differentiation;GO:0009624 response to nematode", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88851-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21784-1", "uniprot_id": "RAG2_MOUSE", "mass": 59074.0, "length": 527, "protein_name": "V(D)J recombination-activating protein 2", "gene_name": "Rag2", "organism": "Mouse", "refseq_name": "V(D)J recombination-activating protein 2", "refseq_ac": "NP_033046", "gene_names_uniprotkb": "Rag2; Rag-2", "gene_names_refseq": "Rag-2; Rag2", "protein_names_uniprotkb": "V(D)J recombination-activating protein 2; RAG-2", "protein_names_refseq": "V(D)J recombination-activating protein 2; recombinase activating gene 2", "tax_id": 10090, "disease": "Omenn syndrome (Disease Ontology:DOID:0060010); severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive (Disease Ontology:DOID:0090013); combined cellular and humoral immune defects with granulomas (Disease Ontology:DOID:0112253); severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": " (mmu:19374)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10601032;1547487;15964836;16111638;18025461;18033247;18724932;19396172;19448632;19524534;21349429;2360047;8521468;8986717;9094713;9184213", "class_list": "", "function": "Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 20, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008270 zinc ion binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0097519 DNA recombinase complex", "go_biological_process": "GO:0002360 T cell lineage commitment;GO:0006310 DNA recombination;GO:0030183 B cell differentiation;GO:0042742 defense response to bacterium;GO:0033077 T cell differentiation in thymus", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P21784-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62878-1", "uniprot_id": "RBX1_MOUSE", "mass": 12274.0, "length": 108, "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "Rbx1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RBX1", "refseq_ac": "NP_062686", "gene_names_uniprotkb": "Rbx1", "gene_names_refseq": "1500002P15Rik; ROC1; Rbx1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RBX1; 2.3.2.27; 2.3.2.32; E3 ubiquitin-protein transferase RBX1; RING finger protein 75; RING-box protein 1; Rbx1", "protein_names_refseq": "E3 ubiquitin-protein ligase RBX1; E3 ubiquitin-protein transferase RBX1; RING finger protein 75; ring-box protein 1", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:56438); (R-MMU-110314); (R-MMU-1170546); (R-MMU-1234176); (R-MMU-195253); (R-MMU-4641258); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5696394); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-68949); (R-MMU-69601); (R-MMU-8854050); (R-MMU-8939902); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9708530); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-983168); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9954709)", "pathway_count": 29, "publication_count": 12, "publication_id_list": "10213691;10643962;11384984;12140560;21750661;22118460;24357321;33590678;34428180;35641500;35978186;37639640", "class_list": "", "function": "E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:22118460, PubMed:33590678, PubMed:35978186). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components (By similarity). As a component of the CSA complex mediates ubiquitination of Pol II subunit RPB1 at 'Lys-1268', a critical TC-NER checkpoint (By similarity). Core component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Core component of a Cul9-RING ubiquitin ligase complex composed of CUL9 and RBX1, which mediates mono-ubiquitination of p53/TP53 (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate (By similarity). Probably also stimulates CDC34 autoubiquitination (By similarity). May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair (By similarity). Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M (By similarity). Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity). In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (By similarity). As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; RING box protein-1(RBX1), a key component of SCF E3 ligase, induced multiple myeloma cell drug-resistance though suppressing p27., [RefSeq, PubMed]; The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8N6Z8;Q9D1S2;Q9WUK9;Q9Y254", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;5.6.2.3;3.4.19.12;3.4.-.-;3.4.25.1;2.4.2.-;2.4.2.30;3.1.13.-;2.7.7.48;2.7.7.6;3.1.-.-;6.5.1.1;3.1.3.48;5.6.2.4;2.7.7.7;3.1.11.-;2.3.2.24;2.3.2.23;1.14.11.-;1.11.1.-;3.6.4.12;2.3.2.34;3.1.3.16;2.3.2.32;2.7.11.1;3.6.4.6;2.7.11.22;2.7.11.23;2.7.11.24;2.7.10.2;2.3.2.36;3.6.4.13;2.3.2.25;1.14.11.29;6.2.1.-;5.2.1.8;2.7.11.26", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0030891 VCB complex;GO:0031467 Cul7-RING ubiquitin ligase complex;GO:0000109 nucleotide-excision repair complex;GO:0005634 nucleus", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0000045 autophagosome assembly;GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P62878-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62965-1", "uniprot_id": "RABP1_MOUSE", "mass": 15592.0, "length": 137, "protein_name": "Cellular retinoic acid-binding protein 1", "gene_name": "Crabp1", "organism": "Mouse", "refseq_name": "cellular retinoic acid-binding protein 1 isoform 1", "refseq_ac": "NP_038524", "gene_names_uniprotkb": "Crabp1", "gene_names_refseq": "CRABP-I; Crabp-1; Crabp1; CrabpI; Rbp-5", "protein_names_uniprotkb": "Cellular retinoic acid-binding protein 1; CRABP-I; Cellular retinoic acid-binding protein I", "protein_names_refseq": "cellular retinoic acid-binding protein 1 isoform 1; cellular retinoic acid-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:12903); (R-MMU-5365859)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "1377826;2171550;2538228;2546063;2547683;31219806;34428180;39075476;7563063;7704533", "class_list": "", "function": "CRABP1-complexes in exosome secretion. Publication Status: Online-Only, [RefSeq, PubMed]; Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02695;P02697;P15780;Q3UN78", "ec_number_list": "", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0005501 retinoid binding;GO:0001972 retinoic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P62965-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70270-1", "uniprot_id": "RAD54_MOUSE", "mass": 84694.0, "length": 747, "protein_name": "DNA repair and recombination protein RAD54-like", "gene_name": "Rad54l", "organism": "Mouse", "refseq_name": "DNA repair and recombination protein RAD54-like isoform 1", "refseq_ac": "NP_001116430", "gene_names_uniprotkb": "Rad54l; Rad54", "gene_names_refseq": "RAD54; Rad54l", "protein_names_uniprotkb": "DNA repair and recombination protein RAD54-like; 3.6.4.-; RAD54 homolog; mHR54; mRAD54", "protein_names_refseq": "DNA repair and recombination protein RAD54-like isoform 1; RAD54 homolog; mHR54; mRAD54", "tax_id": 10090, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); sclerocornea (Disease Ontology:DOID:0060252); disease of cellular proliferation (Disease Ontology:DOID:14566); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:19366)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10209103;10757799;12218123;12531026;12897131;15175260;25428506;31219806;8805304;9108475", "class_list": "", "function": "Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:10209103, PubMed:10757799, PubMed:12218123, PubMed:12531026, PubMed:15175260). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSR5;Q8C2C4;Q8K3D4", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0036310 ATP-dependent DNA/DNA annealing activity;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P70270-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97950-1", "uniprot_id": "RB33A_MOUSE", "mass": 26541.0, "length": 237, "protein_name": "Ras-related protein Rab-33A", "gene_name": "Rab33a", "organism": "Mouse", "refseq_name": "ras-related protein Rab-33A isoform 1", "refseq_ac": "NP_035358", "gene_names_uniprotkb": "Rab33a; Rabs10", "gene_names_refseq": "Rab33a; Rabs10", "protein_names_uniprotkb": "Ras-related protein Rab-33A; 3.6.5.2; Small GTP-binding protein S10", "protein_names_refseq": "RAB33A, member of RAS oncogene family; ras-related protein Rab-33A isoform 1; ras-related protein Rab-33A; small GTP-binding protein S10", "tax_id": 10090, "disease": "", "pathway": " (mmu:19337); (R-MMU-8854214); (R-MMU-8873719)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "18448665;22972995;9116044", "class_list": "", "function": "Studies examining overexpression and inhibition of rat Rab33a suggest that this protein is involved in the transport of post-Golgi synaptophysin-positive vesicles and axon growth in the rat brain., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Modulates autophagosome formation through interaction with ATG16L1 (PubMed:18448665)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a member of the Ras-related small GTPases, which regulate membrane trafficking in organelles and transport vesicles. This protein has been reported to be expressed in lymphocytes and in regions of the mouse brain, specifically the cortex, hippocampus and also the olfactory bulb. The ortholog of this protein in rat has been characterized and may participate in anterograde trafficking of synaptophysin-positive vesicles to the plasma membrane. [provided by RefSeq, Jun 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;2.5.1.60;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0032482 Rab protein signal transduction;GO:0019882 antigen processing and presentation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97950-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q148R9-1", "uniprot_id": "R9BP_MOUSE", "mass": 25177.0, "length": 237, "protein_name": "Regulator of G protein signaling 9-binding protein", "gene_name": "Rgs9bp", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 9-binding protein", "refseq_ac": "NP_665839", "gene_names_uniprotkb": "Rgs9bp; R9ap", "gene_names_refseq": "R9AP; Rgs9-1bp; Rgs9bp", "protein_names_uniprotkb": "Regulator of G protein signaling 9-binding protein; RGS9-anchoring protein", "protein_names_refseq": "RGS9 anchor protein; RGS9-1 anchor; RGS9-anchoring protein; regulator of G-protein signaling 9-binding protein", "tax_id": 10090, "disease": "bradyopsia 2 (Disease Ontology:DOID:0070364)", "pathway": " (mmu:243923); (R-MMU-2514859)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12119397;12499365;12560335;14614075;14625292;14664818;16908407;16939221;24526444;25009288", "class_list": "", "function": "Photoreceptors R9AP determines the stability of the RGS9.Gbeta5 complex, and therefore all three proteins, RGS9, Gbeta5 , and R9AP, are obligate members of the regulatory complex that speeds the rate at which transducin hydrolyzes GTP., [RefSeq, PubMed]; R9AP is actively targeted in rods by its SNARE homology domain., [RefSeq, PubMed]; Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The presence of a second, R9AP-expressing transgene in the iCre75 mouse line, leading to altered kinetics of phototransduction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K462", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0043005 neuron projection;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction;GO:0050908 detection of light stimulus involved in visual perception", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q148R9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TMX7-1", "uniprot_id": "QSOX2_MOUSE", "mass": 77775.0, "length": 692, "protein_name": "Sulfhydryl oxidase 2", "gene_name": "Qsox2", "organism": "Mouse", "refseq_name": "sulfhydryl oxidase 2 isoform 1 precursor", "refseq_ac": "NP_001289885", "gene_names_uniprotkb": "Qsox2; Qscn6l1", "gene_names_refseq": "Qscn6l1; Qsox2; Soxn", "protein_names_uniprotkb": "Sulfhydryl oxidase 2; 1.8.3.2; Quiescin Q6-like protein 1", "protein_names_refseq": "quiescin Q6-like 1; sulfhydryl oxidase 2 isoform 1 precursor; sulfhydryl oxidase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:227638)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29800099;38504307", "class_list": "", "function": "Our study provides the first comprehensive comparisons between QSOX1 and QSOX2 in the mouse epididymis, revealing their distinct epididymal distribution, cellular localization, mechanisms of secretion and sperm membrane association, [RefSeq, PubMed]; Sulfhydryl oxidase that catalyzes the oxidation of protein thiol groups to form disulfide bonds, with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in secreted proteins (By similarity). May play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis (By similarity). Required for normal ovarian function (PubMed:38504307)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; This gene encodes a member of the sulfhydryl oxidase protein family. Members of this family catalyze formation of disulfide bonds. A similar protein in humans may sensitize neuroblastoma cells to interferon gamma-induced cell death. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2ALE0;A2ALE1;Q3TZA5;Q8C9I4;Q8K0M2", "ec_number_list": "1.8.3.2", "go_molecular_function": "GO:0016971 flavin-dependent sulfhydryl oxidase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TMX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61820-1", "uniprot_id": "RANT_MOUSE", "mass": 24452.0, "length": 216, "protein_name": "GTP-binding nuclear protein Ran, testis-specific isoform", "gene_name": "Rasl2-9", "organism": "Mouse", "refseq_name": "GTP-binding nuclear protein Ran, testis-specific isoform", "refseq_ac": "NP_033054", "gene_names_uniprotkb": "Rasl2-9", "gene_names_refseq": "M2; Ran/M2; Ran; Rasl2-9-ps; Rasl2-9", "protein_names_uniprotkb": "GTP-binding nuclear protein Ran, testis-specific isoform; 3.6.5.-", "protein_names_refseq": "GTP-binding nuclear protein Ran, testis-specific isoform; RAS-like, family 2, locus 9, pseudogene", "tax_id": 10090, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:19428)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "23386199;25428506;26740625;30084848;30779550;31219806;32152506;7849398", "class_list": "", "function": "GTP-binding protein involved in nucleocytoplasmic transport (By similarity). Required for the import of protein into the nucleus and also for RNA export (By similarity). Involved in chromatin condensation and control of cell cycle (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZF4;Q6P8M7;Q80YD4;Q9D9Y0", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046982 protein heterodimerization activity;GO:0019003 GDP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0000055 ribosomal large subunit export from nucleus;GO:1902570 protein localization to nucleolus;GO:0061015 snRNA import into nucleus;GO:0000054 ribosomal subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q61820-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62151-1", "uniprot_id": "RAGE_MOUSE", "mass": 42654.0, "length": 402, "protein_name": "Advanced glycation end product-specific receptor", "gene_name": "Ager", "organism": "Mouse", "refseq_name": "advanced glycosylation end product-specific receptor isoform b precursor", "refseq_ac": "NP_001258351", "gene_names_uniprotkb": "Ager; Rage", "gene_names_refseq": "Ager; RAGE", "protein_names_uniprotkb": "Advanced glycation end product-specific receptor; Receptor for advanced glycation end products", "protein_names_refseq": "advanced glycation end-products receptor; advanced glycosylation end product-specific receptor isoform b precursor; receptor for advanced glycosylation end products", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); chorioamnionitis (Disease Ontology:DOID:0050697); diabetic encephalopathy (Disease Ontology:DOID:0050850); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); chronic pancreatitis (Disease Ontology:DOID:0051065); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); lupus nephritis (Disease Ontology:DOID:0080162); colorectal carcinoma (Disease Ontology:DOID:0080199); mild cognitive impairment (Disease Ontology:DOID:0080832); prostate cancer (Disease Ontology:DOID:10283); schizotypal personality disorder (Disease Ontology:DOID:10646); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); intracranial aneurysm (Disease Ontology:DOID:10941); adult respiratory distress syndrome (Disease Ontology:DOID:11394); osteoporosis (Disease Ontology:DOID:11476); morbid obesity (Disease Ontology:DOID:11981); diabetic polyneuropathy (Disease Ontology:DOID:12785); cardiovascular system disease (Disease Ontology:DOID:1287); thromboangiitis obliterans (Disease Ontology:DOID:12918); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); Kawasaki disease (Disease Ontology:DOID:13378); aspergillosis (Disease Ontology:DOID:13564); cystic fibrosis (Disease Ontology:DOID:1485); alcohol use disorder (Disease Ontology:DOID:1574); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); optic nerve disease (Disease Ontology:DOID:1891); melanoma (Disease Ontology:DOID:1909); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); Takayasu's arteritis (Disease Ontology:DOID:2508); asthma (Disease Ontology:DOID:2841); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); uremia (Disease Ontology:DOID:4676); liver cirrhosis (Disease Ontology:DOID:5082); aortic disease (Disease Ontology:DOID:520); schizophrenia (Disease Ontology:DOID:5419); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); gastrointestinal system disease (Disease Ontology:DOID:77); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); Cor pulmonale (Disease Ontology:DOID:8515); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); vascular skin disease (Disease Ontology:DOID:9540); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11596); (R-MMU-445989); (R-MMU-879415); (R-MMU-933542)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10399917;14656967;16503878;18539754;19164451;19901339;19906677;21183079;21270403;23679870;24260107;28977635;32338774;32670276;35974093;36807739;9224812", "class_list": "", "function": "Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, histones, phospholipids and glycosaminoglycans (PubMed:21270403, PubMed:32670276). Advanced glycation end products (AGEs) are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. These ligands accumulate at inflammatory sites during the pathogenesis of various diseases including diabetes, vascular complications, neurodegenerative disorders and cancers, and RAGE transduces their binding into pro-inflammatory responses. Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction of inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (By similarity). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons (PubMed:19901339). ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability (By similarity). Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome (By similarity). Binds to DNA and promotes extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (By similarity). Mediates phagocytosis by non-professional phagocytes (NPP) and this is enhanced by binding to ligands including RNA, DNA, HMGB1 and histones (By similarity). Promotes NPP-mediated phagocytosis of Saccharomyces cerevisiae spores by binding to RNA attached to the spore wall (PubMed:35974093). Also promotes NPP-mediated phagocytosis of apoptotic cells (By similarity). Following DNA damage, recruited to DNA double-strand break sites where it colocalizes with the MRN repair complex via interaction with double-strand break repair protein MRE11 (PubMed:28977635). Enhances the endonuclease activity of MRE11, promoting the end resection of damaged DNA (PubMed:28977635). Promotes DNA damage repair in trophoblasts which enhances trophoblast invasion and contributes to placental development and maintenance (By similarity). Protects cells from DNA replication stress by localizing to damaged replication forks where it stabilizes the MCM2-7 complex and promotes faithful progression of the replication fork (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Down-regulates receptor for advanced glycation end products (RAGE)-ligand induced signaling through various MAPK pathways including ERK1/2, p38 and SAPK/JNK. Significantly affects tumor cell properties through decreasing cell migration, invasion, adhesion and proliferation, and increasing cellular apoptosis. Exhibits drastic inhibition on tumorigenesis in vitro., [UniProtKB, PubMed]; Is able to inhibit advanced glycation end product (AGE)-induced nuclear factor NF-kappa-B activation., [UniProtKB, PubMed]; Results suggest that the murine receptor for advanced glycation end-products (RAGE) gene undergoes extensive splicing with distinct splice isoforms being uniquely distributed in different tissues., [RefSeq, PubMed]; The murine equivalent of esRAGE was isolated from brain polysomal poly(A)+ (polyadenylated) RNA by RT (reverse transcription)-PCR cloning. Its expression is increased in kidneys of diabetic mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 72, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "C5H3H4;C5H3H5;C5H3H7;C5H3I0;C5H7W3;C5H7W4;C5H7W5;C5H7W6;C5H7W7;C5H7W8;C5H7W9;O35444;Q2PGG1;V5R4Y0", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:1904599 advanced glycation end-product binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005769 early endosome", "go_biological_process": "GO:1900744 regulation of p38MAPK cascade;GO:2001200 positive regulation of dendritic cell differentiation;GO:0032693 negative regulation of interleukin-10 production;GO:0001914 regulation of T cell mediated cytotoxicity;GO:1904597 negative regulation of connective tissue replacement involved in inflammatory response wound healing", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q62151-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64701-1", "uniprot_id": "RBL1_MOUSE", "mass": 119456.0, "length": 1063, "protein_name": "Retinoblastoma-like protein 1", "gene_name": "Rbl1", "organism": "Mouse", "refseq_name": "retinoblastoma-like protein 1 isoform 2", "refseq_ac": "NP_001132988", "gene_names_uniprotkb": "Rbl1", "gene_names_refseq": "PRB1; Rbl1; p107", "protein_names_uniprotkb": "Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; p107; pRb1", "protein_names_refseq": "107 kDa retinoblastoma-associated protein; retinoblastoma-like 1 (p107); retinoblastoma-like protein 1 isoform 2; retinoblastoma-like protein 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:19650); (R-MMU-1538133); (R-MMU-2173796); (R-MMU-69231)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "11571651;15750587;17242355;21183079;31219806;34418053;34428180;36852467;7490090;8661722", "class_list": "", "function": "Key regulator of entry into cell division (By similarity). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (PubMed:15750587). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (PubMed:15750587). Controls histone H4 'Lys-20' trimethylation (PubMed:15750587). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (PubMed:15750587). Potent inhibitor of E2F-mediated trans-activation (By similarity). May act as a tumor suppressor (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1D4", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:2000773 negative regulation of cellular senescence", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q64701-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66JV4-1", "uniprot_id": "R12BB_MOUSE", "mass": 96450.0, "length": 834, "protein_name": "RNA-binding protein 12B-B", "gene_name": "Rbm12b2", "organism": "Mouse", "refseq_name": "RNA-binding protein 12B-B", "refseq_ac": "NP_945195", "gene_names_uniprotkb": "Rbm12b2; Rbm12bb", "gene_names_refseq": "C430048L16Rik; Rbm12b2; Rbm12bb", "protein_names_uniprotkb": "RNA-binding protein 12B-B; RNA-binding motif protein 12B-B", "protein_names_refseq": "RNA-binding motif protein 12B-B; RNA-binding protein 12B-B", "tax_id": 10090, "disease": "", "pathway": " (mmu:77604)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJP4;Q3TE05;Q8BNP2;Q8K0T9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66JV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TN89-1", "uniprot_id": "RASE_MOUSE", "mass": 24321.0, "length": 227, "protein_name": "GTPase ERas", "gene_name": "Eras", "organism": "Mouse", "refseq_name": "GTPase ERas", "refseq_ac": "NP_853526", "gene_names_uniprotkb": "Eras", "gene_names_refseq": "Eras; HRAS2; HRasp; Ha-Ras2; ecat5", "protein_names_uniprotkb": "GTPase ERas; 3.6.5.2; E-Ras; Embryonic stem cell-expressed Ras", "protein_names_refseq": "GTPase ERas; embryonic stem cell-expressed Ras; small GTPase E-Ras", "tax_id": 10090, "disease": "", "pathway": " (mmu:353283)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12774123;16046393;18174262;19266163;26269429", "class_list": "", "function": "ERAS may also play important roles in cell lineage specification during mouse early embryonic development., [RefSeq, PubMed]; ERas and Rheb are two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway; ERas is localized at the plasma membrane, while Rheb is on endomembranes., [RefSeq, PubMed]; Galectin-1 increased DNA synthesis in mouse ES cells via Src, caveolin-1 Akt, and mTOR signaling pathways, [RefSeq, PubMed]; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells., [UniProtKB, PubMed]; RasH2 may have a role in susceptibility to chemically-induced tongue and esophageal neoplasms, [RefSeq, PubMed]; Transforming oncogene ERas is important in the tumour-like growth properties of embryonic stem cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TN89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YR9-1", "uniprot_id": "R12BA_MOUSE", "mass": 96596.0, "length": 836, "protein_name": "RNA-binding protein 12B-A", "gene_name": "Rbm12b1", "organism": "Mouse", "refseq_name": "RNA-binding protein 12B-A", "refseq_ac": "NP_082502", "gene_names_uniprotkb": "Rbm12b1; Rbm12ba; Rbm12b", "gene_names_refseq": "3000004N20Rik; Rbm12b1; Rbm12ba; Rbm12b", "protein_names_uniprotkb": "RNA-binding protein 12B-A; RNA-binding motif protein 12B-A", "protein_names_refseq": "RNA binding motif protein 12B; RNA-binding motif protein 12B-A; RNA-binding protein 12B-A", "tax_id": 10090, "disease": "", "pathway": " (mmu:72397)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21183079;23806337;25605945;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AZ74;Q7TQK7;Q8CD70;Q9CRY6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80YR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH73-1", "uniprot_id": "QPCTL_MOUSE", "mass": 42692.0, "length": 383, "protein_name": "Glutaminyl-peptide cyclotransferase-like protein", "gene_name": "Qpctl", "organism": "Mouse", "refseq_name": "glutaminyl-peptide cyclotransferase-like protein", "refseq_ac": "NP_080387", "gene_names_uniprotkb": "Qpctl", "gene_names_refseq": "1810019P04Rik; Qpctl; gQC", "protein_names_uniprotkb": "Glutaminyl-peptide cyclotransferase-like protein; 2.3.2.5; Golgi-resident glutaminyl-peptide cyclotransferase; gQC; isoQC", "protein_names_refseq": "glutaminyl-peptide cyclotransferase-like protein; golgi-resident glutaminyl-peptide cyclotransferase; isoQC", "tax_id": 10090, "disease": "", "pathway": " (mmu:67369)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18486145;31219806;31599954;35314846;36459066", "class_list": "", "function": "Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity., [RefSeq, PubMed]; Responsible for the biosynthesis of pyroglutamyl peptides., [UniProtKB]; Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8T5;Q9D8Y3", "ec_number_list": "2.3.2.5", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016603 glutaminyl-peptide cyclotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BH73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKD6-1", "uniprot_id": "R144B_MOUSE", "mass": 33495.0, "length": 301, "protein_name": "E3 ubiquitin-protein ligase RNF144B", "gene_name": "Rnf144b", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF144B", "refseq_ac": "NP_001164114", "gene_names_uniprotkb": "Rnf144b; Ibrdc2", "gene_names_refseq": "E130105P19Rik; Ibrdc2; Pir2; Rnf144b", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF144B; 2.3.2.31; IBR domain-containing protein 2; RING finger protein 144B", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF144B; IBR domain containing 2; IBR domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:218215); (R-MMU-983168)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20615966;37088470;38685100;39285245", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Plays a crucial role in maintaining the genomic stability by controlling the degradation of multiple proteins involved in mitotic progression and DNA damage. Regulates epithelial homeostasis by mediating degradation of CDKN1A and isoform 2 of TP63. Plays a regulatory role in innate immunity by negatively regulating IRF3 activation and IFN-beta production. Mechanistically, inhibits TBK1 phosphorylation and 'Lys-63'-linked polyubiquitination independently of its E3 ligase activity. Alternatively, promotes 'Lys-27' and 'Lys-33'-linked ubiquitination of IFIH1/MDA5, promoting selective autophagic degradation of IFIH1/MDA5 to inhibit antiviral response (PubMed:39285245)., [UniProtKB, UniProtKB, PubMed]; PIR2, by being induced by TAp73 and degrading DeltaNp73, differentially regulates TAp73/DeltaNp73 stability.[PIR2], [RefSeq, PubMed]; RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation., [RefSeq, PubMed]; Rnf144b alleviates the inflammatory responses and cardiac dysfunction in sepsis., [RefSeq, PubMed]; The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG97;Q8R195", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BKD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BND5-1", "uniprot_id": "QSOX1_MOUSE", "mass": 82785.0, "length": 748, "protein_name": "Sulfhydryl oxidase 1", "gene_name": "Qsox1", "organism": "Mouse", "refseq_name": "sulfhydryl oxidase 1 isoform a precursor", "refseq_ac": "NP_001020116", "gene_names_uniprotkb": "Qsox1; Qscn6; Sox", "gene_names_refseq": "1300003H02Rik; QSOX; Qscn6; Qsox1; SOx; b2b2673Clo", "protein_names_uniprotkb": "Sulfhydryl oxidase 1; 1.8.3.2; Quiescin Q6; Skin sulfhydryl oxidase; mSOx", "protein_names_refseq": "skin sulfhydryl oxidase; sulfhydryl oxidase 1 isoform a precursor; sulfhydryl oxidase 1", "tax_id": 10090, "disease": "VACTERL association (Disease Ontology:DOID:14679)", "pathway": " (mmu:104009); (R-MMU-114608); (R-MMU-381426); (R-MMU-6798695); (R-MMU-8957275)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;12354420;16160860;22801504;23386199;25428506;26495903;26740625;26819240;28011936;30367560;34428180;35809071;36245281;37828378", "class_list": "", "function": "Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:26819240). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:26819240). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:26819240)., [UniProtKB, PubMed]; Cloned skin SOx cDNA and characterized it as one of the disulfide (S-S) cross-linking enzymes, [RefSeq, PubMed]; Functional significance of mouse seminal vesicle sulfhydryl oxidase on sperm capacitation in vitro., [RefSeq, PubMed]; In seminiferous tubules, where a high level of expression was noticed, QSOX might play an important physiological role in sperm function and serve as a marker for the diagnosis of male infertility., [RefSeq, PubMed]; The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDY9;Q3TE19;Q3TR29;Q3UEL4;Q8K041;Q9DBL6", "ec_number_list": "3.4.24.81;3.2.1.18;3.4.24.34;3.4.22.27;1.1.1.42;3.4.21.46;4.1.2.13;3.4.21.4;3.4.21.-;3.6.4.-;3.2.1.17;5.3.4.1;1.16.3.1;3.4.23.5;3.3.2.6;3.4.11.4;3.1.3.48;3.4.21.69;3.4.24.35;1.8.3.2;3.5.4.5;3.6.5.2;3.4.21.37;2.7.11.1;1.11.1.27;1.11.1.9;1.16.3.4;3.5.3.1;3.2.1.166;2.4.1.145;2.3.2.13;3.1.1.4;3.1.1.3;1.8.3.5;1.4.3.22;1.4.3.-;2.7.1.35;3.1.1.98;1.-.-.-;3.6.1.6;2.3.1.16;2.3.1.9;2.3.1.155;2.7.10.2;3.2.1.51;2.3.2.5;5.4.2.2;3.1.21.-;3.2.1.14;3.5.1.3;3.4.21.112;3.4.18.1;3.5.1.23;3.5.1.-;3.4.19.9", "go_molecular_function": "GO:0071949 FAD binding;GO:0016971 flavin-dependent sulfhydryl oxidase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0070062 extracellular exosome", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0006457 protein folding;GO:0016242 negative regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8BND5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C779-1", "uniprot_id": "RADX_MOUSE", "mass": 96847.0, "length": 850, "protein_name": "RPA-related protein RADX", "gene_name": "Radx", "organism": "Mouse", "refseq_name": "RPA-related protein RADX isoform 2", "refseq_ac": "NP_001333451", "gene_names_uniprotkb": "Radx", "gene_names_refseq": "D330045A20Rik; Radx", "protein_names_uniprotkb": "RPA-related protein RADX", "protein_names_refseq": "RPA-related protein RADX isoform 2; RPA-related protein RADX; likely orthologue of H. sapiens Chromosome X open reading frame 57 (CXorf57); uncharacterized protein CXorf57 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:102871)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AGL6;Q3TB47", "ec_number_list": "", "go_molecular_function": "GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005657 replication fork", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006282 regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8C779-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1I1-1", "uniprot_id": "QCR9_MOUSE", "mass": 7446.0, "length": 64, "protein_name": "Cytochrome b-c1 complex subunit 9", "gene_name": "Uqcr10", "organism": "Mouse", "refseq_name": "cytochrome b-c1 complex subunit 9 isoform 1", "refseq_ac": "NP_932096", "gene_names_uniprotkb": "Uqcr10", "gene_names_refseq": "1110020P15Rik; Ucrc; Uqcr10", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 9; Complex III subunit 9; Complex III subunit X; Cytochrome c1 non-heme 7 kDa protein; Ubiquinol-cytochrome c reductase complex 7.2 kDa protein", "protein_names_refseq": "complex III subunit 9; complex III subunit X; cytochrome b-c1 complex subunit 9 isoform 1; cytochrome b-c1 complex subunit 9; cytochrome c1 non-heme 7 kDa protein; ubiquinol-cytochrome c reductase complex (7.2 kD); ubiquinol-cytochrome c reductase complex 7.2 kDa protein; ubiquinol-cytochrome c reductase complex protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66152); (R-MMU-611105); (R-MMU-9865881)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "16075062;19026783;31219806;34428180;34616041;36288343;37453647;38575788", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R1I1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE92-1", "uniprot_id": "RBM4B_MOUSE", "mass": 39991.0, "length": 357, "protein_name": "RNA-binding protein 4B", "gene_name": "Rbm4b", "organism": "Mouse", "refseq_name": "RNA-binding protein 4B", "refseq_ac": "NP_079993", "gene_names_uniprotkb": "Rbm4b; Rbm30", "gene_names_refseq": "4921506I22Rik; Lark2; Neosin; Rbm4b", "protein_names_uniprotkb": "RNA-binding protein 4B; RNA-binding motif protein 30; RNA-binding motif protein 4B; RNA-binding protein 30", "protein_names_refseq": "RNA-binding motif protein 30; RNA-binding protein 30; RNA-binding protein 4B", "tax_id": 10090, "disease": "", "pathway": " (mmu:66704)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17264215;21750661;25428506;25605945;30084848;30779550;34428180", "class_list": "", "function": "Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0010628 positive regulation of gene expression;GO:0007623 circadian rhythm;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VE92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V41-1", "uniprot_id": "RAB14_MOUSE", "mass": 23897.0, "length": 215, "protein_name": "Ras-related protein Rab-14", "gene_name": "Rab14", "organism": "Mouse", "refseq_name": "ras-related protein Rab-14", "refseq_ac": "NP_080973", "gene_names_uniprotkb": "Rab14", "gene_names_refseq": "0610030G24Rik; 2810475J17Rik; A830021G03Rik; D030017L14Rik; Rab14", "protein_names_uniprotkb": "Ras-related protein Rab-14; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-14", "tax_id": 10090, "disease": "", "pathway": " (mmu:68365); (R-MMU-1660499); (R-MMU-6798695); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;16075062;19224205;20173027;21238925;21750661;22645316;24788674;25428506;26740625;26936971;28528544;30084848;31219806;32152506;33300544;34323331;34428180", "class_list": "", "function": "RAB14 GTPase is essential for actin-based asymmetric division during mouse oocyte maturation., [RefSeq, PubMed]; Rab14 limits the sorting of Glut4 from endosomes into insulin-sensitive regulated secretory compartments in adipocytes.(, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB14 is involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development (By similarity). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (PubMed:21238925). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB4B (By similarity). Interaction with RAB11FIP1 may function in the process of neurite formation (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;2.3.2.27;7.6.2.1;3.1.3.48;3.6.5.2;3.6.5.3;3.4.24.81;3.6.1.5;3.4.21.73;3.6.5.4;3.6.5.5;2.5.1.60;3.6.4.-;1.1.1.-;3.2.1.20;3.6.1.-;3.4.24.-;3.6.1.15;2.3.1.78;2.7.11.1;1.6.3.-;3.6.-.-;3.1.4.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0032880 regulation of protein localization;GO:0007589 body fluid secretion;GO:0042742 defense response to bacterium;GO:0034058 endosomal vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q91V41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WG2-3", "uniprot_id": "RABE2_MOUSE", "mass": 62132.0, "length": 554, "protein_name": "Rab GTPase-binding effector protein 2", "gene_name": "Rabep2", "organism": "Mouse", "refseq_name": "rab GTPase-binding effector protein 2", "refseq_ac": "NP_085043", "gene_names_uniprotkb": "Rabep2; Rabpt5b", "gene_names_refseq": "2610011A08Rik; Fra; Rabep2", "protein_names_uniprotkb": "Rab GTPase-binding effector protein 2; Rabaptin-5beta", "protein_names_refseq": "fos-related antigen; rab GTPase-binding effector protein 2; rabaptin-5beta", "tax_id": 10090, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (mmu:70314)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "18299400;25428506;26495903;27224062;27811335;28528544;29425100;30084848;30779550;31219806;34428180", "class_list": "", "function": "Naturally occurring variants of Rabep2 are major determinants of variation in collateral extent and stroke severity in mice., [RefSeq, PubMed]; Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis., [UniProtKB, UniProtKB]; SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, AZI1), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome. Publication Status: Online-Only, [RefSeq, PubMed]; These results implicate RABEP2 as a key modulator of VEGFR2 endosomal trafficking, and demonstrate the importance of RABEP2 and Rab4 for VEGFR2 signaling in endothelial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMK8;Q99KN3", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0036064 ciliary basal body", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0030030 cell projection organization;GO:1902017 regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q91WG2-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D1G1-1", "uniprot_id": "RAB1B_MOUSE", "mass": 22187.0, "length": 201, "protein_name": "Ras-related protein Rab-1B", "gene_name": "Rab1b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-1B", "refseq_ac": "NP_083852", "gene_names_uniprotkb": "Rab1b", "gene_names_refseq": "1110011F09Rik; Rab1b", "protein_names_uniprotkb": "Ras-related protein Rab-1B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-1B", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:76308); (R-MMU-162658); (R-MMU-204005); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 7, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;18842593;21750661;22872234;23188820;28520221;31219806;33300544;33898333;34203471;34428180;39927985", "class_list": "", "function": "A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth. Publication Status: Online-Only, [RefSeq, PubMed]; Identify Rap1b acting downstream of Axin2 as a signaling interrogator for FGF and BMP. Genetic analysis reveals that Rap1b is essential for development of craniofacial and body skeletons. Axin2 regulates Rap1b through modulation of canonical BMP signaling., [RefSeq, PubMed]; Inhibition of PI3K or mTOR reduced the level of Rap1B, which acts downstream of Rheb and mTOR. The ubiquitin E3 ligase Smurf2 mediates the restriction of Rap1B by initiating its degradation., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0N1", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.4.-;5.6.1.3;3.6.5.5;2.5.1.60;3.4.14.1;3.6.1.-;2.7.11.21;3.6.1.15;2.7.11.1;3.6.-.-;2.3.1.-;2.7.11.26;3.4.18.1", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1903020 positive regulation of glycoprotein metabolic process;GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9D1G1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D4V7-1", "uniprot_id": "RABL3_MOUSE", "mass": 26298.0, "length": 236, "protein_name": "Rab-like protein 3", "gene_name": "Rabl3", "organism": "Mouse", "refseq_name": "rab-like protein 3", "refseq_ac": "NP_001035964", "gene_names_uniprotkb": "Rabl3", "gene_names_refseq": "4930553C05Rik; Rabl3", "protein_names_uniprotkb": "Rab-like protein 3; 3.6.5.2", "protein_names_refseq": "RAB, member of RAS oncogene family-like 3; rab-like protein 3", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:67657)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31406347;32220963", "class_list": "", "function": "Small GTPase required for KRAS signaling regulation and modulation of cell proliferation (PubMed:31406347). Regulator of KRAS prenylation, and probably prenylation of other small GTPases (By similarity). Required for lymphocyte development and function (PubMed:32220963). Not required for myeloid cell development (PubMed:32220963). Interacts with Rab11 to promote ciliary vesicle formation at the mother centriole, thereby regulating early ciliogenesis. The GTP-binding capacity of RABL3 is essential for ciliogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMU2;Q9D0M6", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042803 protein homodimerization activity;GO:0003925 G protein activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0012505 endomembrane system", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0006886 intracellular protein transport;GO:0050821 protein stabilization;GO:0030183 B cell differentiation;GO:0033077 T cell differentiation in thymus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D4V7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JI58-1", "uniprot_id": "RAE1D_MOUSE", "mass": 27884.0, "length": 249, "protein_name": "Retinoic acid early-inducible protein 1-delta", "gene_name": "Raet1d", "organism": "Mouse", "refseq_name": "retinoic acid early-inducible protein 1-delta precursor", "refseq_ac": "NP_064414", "gene_names_uniprotkb": "Raet1d", "gene_names_refseq": "RAE-1delta; Raet1d", "protein_names_uniprotkb": "Retinoic acid early-inducible protein 1-delta; RAE-1-delta", "protein_names_refseq": "RAE-1-delta; retinoic acid early transcript 1D; retinoic acid early-inducible protein 1-delta precursor; retinoic acid early-inducible protein 1-delta", "tax_id": 10090, "disease": "", "pathway": " (mmu:56554)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10894171;20166740;27444966;29757143", "class_list": "", "function": "Acts as a ligand for KLRK1., [UniProtKB, PubMed]; Study reports that retinoic acid early induced transcript-1-d and retinoic acid early induced transcript-1-e (Raet1) genes are induced early upon experimental autoimmune encephalomyelitis onset and reach a maximal expression at the peak of the pathology. Study also shows that macrophages as well as microglia, are cellular sources of Raet1 transcripts., [RefSeq, PubMed]; The authors find that a soluble factor produced by tumor cells is responsible for macrophage RAE-1delta induction, and they identify tumor-derived colony-stimulating factor-1 (CSF-1) as necessary and sufficient for macrophage RAE-1delta induction in vitro and in vivo. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQI0", "ec_number_list": "", "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0034235 GPI anchor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0042267 natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JI58-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUP1-1", "uniprot_id": "RAMP3_MOUSE", "mass": 16779.0, "length": 147, "protein_name": "Receptor activity-modifying protein 3", "gene_name": "Ramp3", "organism": "Mouse", "refseq_name": "receptor activity-modifying protein 3 precursor", "refseq_ac": "NP_062384", "gene_names_uniprotkb": "Ramp3", "gene_names_refseq": "Ramp3", "protein_names_uniprotkb": "Receptor activity-modifying protein 3", "protein_names_refseq": "receptor activity-modifying protein 3 precursor; receptor activity-modifying protein 3", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:56089); (R-MMU-418555); (R-MMU-419812)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10777702;10854696;11854283;23674134;38012983", "class_list": "", "function": "Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G protein-coupled estrogen receptor 1 (GPER1) (PubMed:10854696, PubMed:23674134). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane (By similarity). Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (PubMed:23674134). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed:10854696). Together with CALCR, act as a receptor complex for amylin/IAPP (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Receptor activity-modifying proteins of adrenomedullin (RAMP2/3): Roles in the pathogenesis of ARDS., [RefSeq, PubMed]; Role in cell surface expression of CRLR/RAMP heterodimeric receptors, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5SWP4", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0001605 adrenomedullin receptor activity;GO:0097643 amylin receptor activity;GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0005764 lysosome;GO:0150058 amylin receptor complex 3", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WUP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0F6-1", "uniprot_id": "RAD9A_MOUSE", "mass": 42059.0, "length": 389, "protein_name": "Cell cycle checkpoint control protein RAD9A", "gene_name": "Rad9a", "organism": "Mouse", "refseq_name": "cell cycle checkpoint control protein RAD9A", "refseq_ac": "NP_035367", "gene_names_uniprotkb": "Rad9a; Rad9", "gene_names_refseq": "Rad9a; Rad9", "protein_names_uniprotkb": "Cell cycle checkpoint control protein RAD9A; 3.1.11.2; DNA repair exonuclease rad9 homolog A; Rad9-like protein; mRAD9", "protein_names_refseq": "DNA repair exonuclease rad9 homolog A; RAD9 homolog A; Rad9-like protein; cell cycle checkpoint control protein RAD9A; mRAD9", "tax_id": 10090, "disease": "", "pathway": " (mmu:19367); (R-MMU-176187); (R-MMU-5685938); (R-MMU-5693607); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "12709442;15983387;19131326;20305300;21183079;21750661;28135057;30154445;31219806;9766521", "class_list": "", "function": "Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RAD9A may also play an important role in maternal chromatin reprogramming. In summary, our data reveal an important role of RAD9A in zygotic chromatin reprogramming and female fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8QZZ3", "ec_number_list": "2.7.11.1;5.6.2.1;2.3.2.27;5.6.2.4;6.5.1.1;3.6.-.-;3.6.4.-;5.6.2.3;3.1.-.-;2.3.1.48;2.3.1.-;3.1.11.2", "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0017124 SH3 domain binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0030896 checkpoint clamp complex", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0071479 cellular response to ionizing radiation;GO:0031573 mitotic intra-S DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z0F6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTJ5-1", "uniprot_id": "RAMP1_MOUSE", "mass": 16892.0, "length": 148, "protein_name": "Receptor activity-modifying protein 1", "gene_name": "Ramp1", "organism": "Mouse", "refseq_name": "receptor activity-modifying protein 1 isoform 1 precursor", "refseq_ac": "NP_058590", "gene_names_uniprotkb": "Ramp1", "gene_names_refseq": "9130218E19Rik; Ramp1", "protein_names_uniprotkb": "Receptor activity-modifying protein 1", "protein_names_refseq": "receptor activity-modifying protein 1 isoform 1 precursor; receptor activity-modifying protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:51801); (R-MMU-418555); (R-MMU-419812)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10777702;10854696;11733510;12147211;21750661;34428180", "class_list": "", "function": "Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane (PubMed:10854696, PubMed:12147211). Together with CALCRL, form the receptor complex for the calcitonin gene-related peptides CGRP1/CALCA and CGRP2/CALCB. Together with CALCR, form the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane. Together with CALCRL, form the receptor complex for the calcitonin gene-related peptides CGRP1/CALCA and CGRP2/CALCB. Together with CALCR, form the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA., [UniProtKB, UniProtKB, UniProtKB]; Co-expression of RAMP1 and CRLR reconstituted a CGRP receptor that was able to activate the pheromone-signaling pathway with pharmacological properties similar to those observed previously in mammalian cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0001635 calcitonin gene-related peptide receptor activity;GO:0097643 amylin receptor activity;GO:1990407 calcitonin gene-related peptide binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0006886 intracellular protein transport;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WTJ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46061-1", "uniprot_id": "RAGP1_MOUSE", "mass": 63531.0, "length": 589, "protein_name": "Ran GTPase-activating protein 1", "gene_name": "Rangap1", "organism": "Mouse", "refseq_name": "ran GTPase-activating protein 1 isoform 1", "refseq_ac": "NP_001139646", "gene_names_uniprotkb": "Rangap1; Fug1", "gene_names_refseq": "Fug1; Rangap1; mKIAA1835", "protein_names_uniprotkb": "Ran GTPase-activating protein 1; RanGAP1", "protein_names_refseq": "ran GTPase-activating protein 1 isoform 1; ran GTPase-activating protein 1", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (mmu:19387); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-4615885); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9615933); (R-MMU-9648025); (R-MMU-9793242)", "pathway_count": 11, "publication_count": 25, "publication_id_list": "11853669;15037602;15345747;16469311;18305100;19131326;21183079;21750661;26304119;26506250;27717094;28315936;28528544;31088288;31219806;34110283;34428180;35820727;36696903;38729327;39627609;7891706;8314081;9442102;9456312", "class_list": "", "function": "Data suggest that remodeling of the RanGAP-mediated nuclear transport system plays a key role in cell cycle exit for terminal differentiation of cortical neurons, [RefSeq, PubMed]; GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:18305100). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (By similarity). Required for postimplantation embryonic development (PubMed:8314081)., [UniProtKB, UniProtKB, PubMed, PubMed]; Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma., [RefSeq, PubMed]; RanGAP1 maintains chromosome stability in limb bud mesenchymal cells during bone development., [RefSeq, PubMed]; T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-theta-mediated phosphorylation of RanGAP1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 23, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q60801;Q6NZB5", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0005096 GTPase activator activity;GO:0031625 ubiquitin protein ligase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0016925 protein sumoylation;GO:0071375 cellular response to peptide hormone stimulus;GO:0051168 nuclear export;GO:0090630 activation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P46061-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q6X9-1", "uniprot_id": "RHG40_MOUSE", "mass": 74333.0, "length": 672, "protein_name": "Rho GTPase-activating protein 40", "gene_name": "Arhgap40", "organism": "Mouse", "refseq_name": "rho GTPase-activating protein 40", "refseq_ac": "NP_001138487", "gene_names_uniprotkb": "Arhgap40", "gene_names_refseq": "Arhgap40; C20orf95; Gm14203", "protein_names_uniprotkb": "Rho GTPase-activating protein 40; Rho-type GTPase-activating protein 40", "protein_names_refseq": "rho GTPase-activating protein 40; rho-type GTPase-activating protein 40", "tax_id": 10090, "disease": "", "pathway": " (mmu:545481); (R-MMU-8980692); (R-MMU-9013148)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ACC5", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q6X9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99P86-1", "uniprot_id": "RETNB_MOUSE", "mass": 11278.0, "length": 105, "protein_name": "Resistin-like beta", "gene_name": "Retnlb", "organism": "Mouse", "refseq_name": "resistin-like beta precursor", "refseq_ac": "NP_076370", "gene_names_uniprotkb": "Retnlb; Fizz2", "gene_names_refseq": "9030012B21Rik; Fizz2; RELMbeta; Relmb; Retnlb; Xcp3", "protein_names_uniprotkb": "Resistin-like beta; Cysteine-rich secreted protein A12-beta; Cysteine-rich secreted protein FIZZ2; RELMbeta", "protein_names_refseq": "cysteine-rich secreted protein A12-beta; cysteine-rich secreted protein FIZZ2; found in inflammatory zone 2; resistin-like beta precursor; resistin-like molecule beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:57263)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11209052;11358969;14598255;15155948;15834545;21750661;27397737;28973871", "class_list": "", "function": "Lack of RELMbeta leads to increased colonic expression of T helper cell type-2 cytokines and IL-17, associated with a reduced ability to maintain intestinal homeostasis, [RefSeq, PubMed]; Probable hormone., [UniProtKB]; Promotes host-bacterial mutualism by regulating the spatial segregation between the microbiota and the intestinal epithelium, [RefSeq, PubMed]; Secretion of RELMbeta is dramatically reduced in germ-free mice. Furthermore, introduction of germ-free mice into a conventional environment results in enhanced expression and robust secretion of RELMbeta within 48 hours., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D286", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99P86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CF94-1", "uniprot_id": "RHD_MOUSE", "mass": 45877.0, "length": 418, "protein_name": "Blood group Rh(D) polypeptide", "gene_name": "Rhd", "organism": "Mouse", "refseq_name": "blood group Rh(D) polypeptide", "refseq_ac": "NP_035400", "gene_names_uniprotkb": "Rhd; Rh30; Rhced", "gene_names_refseq": "Rhced; Rhd; Rhl1; Rh", "protein_names_uniprotkb": "Blood group Rh(D) polypeptide; Erythrocyte membrane glycoprotein Rh30", "protein_names_refseq": "Rh blood group protein; Rh-like polypeptide; Rhesus blood group CE and D; blood group Rh(D) polypeptide; erythrocyte membrane glycoprotein Rh30", "tax_id": 10090, "disease": "renal tubular acidosis (Disease Ontology:DOID:14219); Rh isoimmunization (Disease Ontology:DOID:4175)", "pathway": " (mmu:19746)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10329015;12459264;16227429;21750661;35820727;36084651;36210013;9705835;9929383", "class_list": "", "function": "May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88296;O88297;Q9QUM6;Q9QX04", "ec_number_list": "", "go_molecular_function": "GO:0008519 ammonium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0170014 ankyrin-1 complex", "go_biological_process": "GO:0097272 ammonium homeostasis;GO:0048821 erythrocyte development;GO:0072488 ammonium transmembrane transport;GO:0060586 multicellular organismal-level iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8CF94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49194-1", "uniprot_id": "RET3_MOUSE", "mass": 134451.0, "length": 1234, "protein_name": "Retinol-binding protein 3", "gene_name": "Rbp3", "organism": "Mouse", "refseq_name": "retinol-binding protein 3 precursor", "refseq_ac": "NP_056560", "gene_names_uniprotkb": "Rbp3", "gene_names_refseq": "Irbp; Rbp-3; Rbp3", "protein_names_uniprotkb": "Retinol-binding protein 3; IRBP; Interphotoreceptor retinoid-binding protein; Interstitial retinol-binding protein", "protein_names_refseq": "interphotoreceptor retinoid-binding protein; retinol-binding protein 3 precursor; retinol-binding protein 3", "tax_id": 10090, "disease": "retinitis pigmentosa 66 (Disease Ontology:DOID:0110393)", "pathway": " (mmu:19661); (R-MMU-2187335); (R-MMU-2453902)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;12434304;1342928;16936108;21750661;22552229;29109151;29187734;38261611;38904640", "class_list": "", "function": "Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia., [RefSeq, PubMed]; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina., [UniProtKB, UniProtKB]; Mediates the transport of 11-cis- and all-trans-retinoids between the retinal pigment epithelium (RPE) and photoreceptors, facilitating retinoid exchange required for the visual cycle., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6B4R6;Q8VD34;Q9R0H8", "ec_number_list": "", "go_molecular_function": "GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0005615 extracellular space;GO:0090658 cone matrix sheath", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P49194-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99NF8-1", "uniprot_id": "RBP17_MOUSE", "mass": 124054.0, "length": 1088, "protein_name": "Ran-binding protein 17", "gene_name": "Ranbp17", "organism": "Mouse", "refseq_name": "ran-binding protein 17 isoform 1", "refseq_ac": "NP_075635", "gene_names_uniprotkb": "Ranbp17", "gene_names_refseq": "Ranbp17", "protein_names_uniprotkb": "Ran-binding protein 17", "protein_names_refseq": "ran-binding protein 17 isoform 1; ran-binding protein 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:66011)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11071879;21184802;21750661;30779550;34428180;35820727", "class_list": "", "function": "Interactions between RANBP17 and SPEM1, for the first time, point to a potential function of SPEM1 in the RANBP17-mediated nucleocytoplasmic transport., [RefSeq, PubMed]; May function as a nuclear transport receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D4E3", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0006611 protein export from nucleus;GO:0051028 mRNA transport;GO:0015031 protein transport;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99NF8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84096-1", "uniprot_id": "RHOG_MOUSE", "mass": 21309.0, "length": 191, "protein_name": "Rho-related GTP-binding protein RhoG", "gene_name": "Rhog", "organism": "Mouse", "refseq_name": "rho-related GTP-binding protein RhoG", "refseq_ac": "NP_062512", "gene_names_uniprotkb": "Rhog; Arhg; Sid10750", "gene_names_refseq": "2810426G09Rik; Arhg; Rhog; Sid10750", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoG; 3.6.5.2; Sid 10750", "protein_names_refseq": "aplysia ras-related homolog G (RhoG); ras homolog G (RhoG); ras homolog gene family, member G; rho-related GTP-binding protein RhoG; sid 10750", "tax_id": 10090, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:56212); (R-MMU-114604); (R-MMU-1257604); (R-MMU-5625970); (R-MMU-6798695); (R-MMU-6811558); (R-MMU-9013408)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12376551;12805377;14701744;21750661;25995380;26495903;26740625;32651375;34428180;39627609", "class_list": "", "function": "Different biological properties of RhoG and Rac1 can be traced to specific amino acid variations in their switch I, beta2/beta3 hairpin, alpha5 helix, and C-terminal polybasic regions., [RefSeq, PubMed]; ELMO2-RhoG-ILK complex has a key role in integrin-independent stabilization of the microtubule network in differentiated keratinocytes., [RefSeq, PubMed]; In RhoG deficient mice, the development of B and T lymphocytes was unaffected. However, there was an increase in the level of serum IgG1 and IgG2b as well as a mild increase of the humoral immune response to thymus-dependent antigens., [RefSeq, PubMed]; Plays a role in immunological synaptic F-actin density and architecture organization (By similarity). Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity (By similarity). Acts as an activator of the ELMO-DOCK-Rac pathway (By similarity). Required for the formation of membrane ruffles during macropinocytosis (By similarity). Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity). Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM) (By similarity). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells (By similarity). Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D (By similarity). Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells (By similarity)., [UniProtKB, UniProtKB]; RhoG function is mediated by signals independent of Rac1 and Cdc42 activation and instead by direct utilization of a subset of common effectors, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P35238;Q8NI04", "ec_number_list": "3.6.5.-;2.7.11.1;3.6.5.2;3.6.5.3;3.2.1.31;2.7.1.153;2.7.1.137;3.6.1.5;2.7.10.2;2.7.10.1;3.1.3.48;3.6.5.4;3.2.2.6;2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;5.6.1.3;3.6.5.5;3.4.11.2;3.6.1.-;3.6.1.15;1.3.1.70;7.6.2.-;3.4.24.11;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;2.7.11.25;3.6.-.-;2.3.1.-;2.1.2.1;7.1.1.2;2.7.1.154;3.1.4.4", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0098794 postsynapse", "go_biological_process": "GO:1900027 regulation of ruffle assembly;GO:0007015 actin filament organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0030036 actin cytoskeleton organization;GO:0007266 Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P84096-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YU81-1", "uniprot_id": "RFX8_MOUSE", "mass": 67285.0, "length": 596, "protein_name": "DNA-binding protein RFX8", "gene_name": "Rfx8", "organism": "Mouse", "refseq_name": "DNA-binding protein RFX8", "refseq_ac": "NP_001139132", "gene_names_uniprotkb": "Rfx8", "gene_names_refseq": "4933400N17Rik; Rfx8", "protein_names_uniprotkb": "DNA-binding protein RFX8; Regulatory factor X 8", "protein_names_refseq": "DNA-binding protein RFX8", "tax_id": 10090, "disease": "", "pathway": " (mmu:619289)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be a transcription factor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3YU81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55240-1", "uniprot_id": "RDH5_MOUSE", "mass": 34826.0, "length": 318, "protein_name": "Retinol dehydrogenase 5", "gene_name": "Rdh5", "organism": "Mouse", "refseq_name": "retinol dehydrogenase 5 isoform b", "refseq_ac": "NP_598767", "gene_names_uniprotkb": "Rdh5; Rdh4; cRDH; rdh", "gene_names_refseq": "9-cis; RDH4; Rdh5; cRDH", "protein_names_uniprotkb": "Retinol dehydrogenase 5; 1.1.1.209; 1.1.1.315; 1.1.1.53; 11-cis RDH; 11-cis RoDH; 11-cis retinol dehydrogenase; 9-cis retinol dehydrogenase; Cis-retinol dehydrogenase", "protein_names_refseq": "11-cis RDH; 11-cis RoDH; 11-cis retinol dehydrogenase; 9-cis-retinol dehydrogenase; retinol dehydrogenase 5 isoform b; retinol dehydrogenase type 5", "tax_id": 10090, "disease": "fundus albipunctatus (Disease Ontology:DOID:11105); night blindness (Disease Ontology:DOID:8499)", "pathway": " (mmu:19682); (R-MMU-2453902); (R-MMU-5365859)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10588954;10739682;10825191;11279029;16223484;21750661;32271812;34428180;9539749;9654122", "class_list": "", "function": "Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:10588954, PubMed:9539749). Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; The longitudinal findings of spectral-domain optical coherence tomography (SD-OCT) in relation to the morphologic features in Rdh5 knockout (Rdh5-/-) mice, was investigated. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;1.1.1.105;1.1.1.315;1.1.1.209;1.1.1.1;1.1.1.66;1.1.1.-;1.1.1.300", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0047023 androsterone dehydrogenase [NAD(P)+] activity;GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity;GO:0106429 11-cis-retinol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane;GO:0044297 cell body", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0042572 retinol metabolic process;GO:0007601 visual perception;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O55240-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08899-1", "uniprot_id": "RGS4_MOUSE", "mass": 23289.0, "length": 205, "protein_name": "Regulator of G protein signaling 4", "gene_name": "Rgs4", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 4", "refseq_ac": "NP_033088", "gene_names_uniprotkb": "Rgs4", "gene_names_refseq": "ESTM48; ESTM50; Rgs4", "protein_names_uniprotkb": "Regulator of G protein signaling 4; RGS4", "protein_names_refseq": "regulator of G-protein signaling 4", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hypertension (Disease Ontology:DOID:10763); opioid abuse (Disease Ontology:DOID:11206); lesion of sciatic nerve (Disease Ontology:DOID:12528); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); bladder disease (Disease Ontology:DOID:365)", "pathway": " (mmu:19736); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;38432633;9425263", "class_list": "", "function": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G protein (By similarity)., [UniProtKB]; RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99L30", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0009898 cytoplasmic side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:1901379 regulation of potassium ion transmembrane transport;GO:1901380 negative regulation of potassium ion transmembrane transport;GO:0060160 negative regulation of dopamine receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08899-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYK4-1", "uniprot_id": "RDH12_MOUSE", "mass": 35292.0, "length": 316, "protein_name": "Retinol dehydrogenase 12", "gene_name": "Rdh12", "organism": "Mouse", "refseq_name": "retinol dehydrogenase 12 isoform 2", "refseq_ac": "NP_001300900", "gene_names_uniprotkb": "Rdh12", "gene_names_refseq": "Rdh12", "protein_names_uniprotkb": "Retinol dehydrogenase 12; 1.1.1.300", "protein_names_refseq": "retinol dehydrogenase 12 isoform 2", "tax_id": 10090, "disease": "Leber congenital amaurosis 13 (Disease Ontology:DOID:0110330); Leber congenital amaurosis (Disease Ontology:DOID:14791); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (mmu:77974); (R-MMU-2453902)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12226107;17032653;17130236;19686838;21750661;22621924;31219806;38552555", "class_list": "", "function": "RDH12 plays a unique, nonredundant role in the photoreceptor inner segments to regulate the flow of retinoids in the eye., [RefSeq, PubMed]; Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity toward 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (By similarity). Plays an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:17032653, PubMed:19686838, PubMed:22621924). Has no dehydrogenase activity towards steroids (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Retinol dehydrogenase 12 (RDH12) knock out may cause hyperuricemia phenotype in mice., [RefSeq, PubMed]; The present findings, together with those of earlier studies showing only minor functional deficits in mice deficient for Rdh5, Rdh8, or Rdh11, suggest that the activity of any one isoform is not rate limiting in the visual response., [RefSeq, PubMed]; The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in the human gene are associated with Leber congenital amaurosis type 13, and Retinitis Pigmentosa 53. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91WA5;Q9D1Y4", "ec_number_list": "1.1.1.300;1.1.1.21;1.1.1.372;1.1.1.54;1.1.1.184;1.1.1.-", "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0102354 11-cis-retinol dehydrogenase (NADP+) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0042572 retinol metabolic process;GO:0007601 visual perception;GO:0110095 cellular detoxification of aldehyde", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BYK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPC5-1", "uniprot_id": "RET7_MOUSE", "mass": 15428.0, "length": 134, "protein_name": "Retinoid-binding protein 7", "gene_name": "Rbp7", "organism": "Mouse", "refseq_name": "retinoid-binding protein 7", "refseq_ac": "NP_071303", "gene_names_uniprotkb": "Rbp7", "gene_names_refseq": "1110002J23Rik; CRBP-III; Rbp7", "protein_names_uniprotkb": "Retinoid-binding protein 7; CRABP-IV; CRABP4; CRBP4; Cellular retinoic acid-binding protein 4; Cellular retinoic acid-binding protein IV", "protein_names_refseq": "CRABP-IV; CRABP4; CRBP4; cellular retinoic acid-binding protein 4; cellular retinoic acid-binding protein IV; cellular retinol binding protein type III; cytosolic binding protein; retinoid-binding protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:63954)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11027338;20530491;21750661;28352663;29803924", "class_list": "", "function": "Conclude that RBP7 is required to mediate the protective effects of PPARgamma in the endothelium through adiponectin, and RBP7 is an endothelium-specific PPARgamma target and regulator of PPARgamma activity Publication Status: Online-Only, [RefSeq, PubMed]; Data showed that the mouse Rbp7 gene produces a predominant isoform in adipose tissue during adipocyte development, cold exposure, and nutritional treatments., [RefSeq, PubMed]; Intracellular transport of retinol., [UniProtKB]; The results provide evidence for an exclusive proteasome subunit-related mechanism for transcriptional activation of RBP4 within a GLUT4 knockdown model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTK0", "ec_number_list": "", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0005501 retinoid binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EPC5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11157-1", "uniprot_id": "RIR2_MOUSE", "mass": 45096.0, "length": 390, "protein_name": "Ribonucleoside-diphosphate reductase subunit M2", "gene_name": "Rrm2", "organism": "Mouse", "refseq_name": "ribonucleoside-diphosphate reductase subunit M2", "refseq_ac": "NP_033130", "gene_names_uniprotkb": "Rrm2", "gene_names_refseq": "R2; Rrm2", "protein_names_uniprotkb": "Ribonucleoside-diphosphate reductase subunit M2; 1.17.4.1; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit", "protein_names_refseq": "ribonucleoside-diphosphate reductase M2 chain; ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase small chain; ribonucleotide reductase small subunit", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); pancreatic cancer (Disease Ontology:DOID:1793); endometrial adenocarcinoma (Disease Ontology:DOID:2870); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (mmu:20135); (R-MMU-499943)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12087093;17242355;19131326;21183079;21750661;25605945;2684652;3025593;31219806;34428180;37482342;38124207;38286859;39259911;7583667;8876648", "class_list": "", "function": "Circular RNA RRM2 alleviates metabolic dysfunction-associated steatotic liver disease by targeting miR-142-5p to increase NRG1 expression., [RefSeq, PubMed]; Identification of RRM2 as a key ferroptosis-related gene in sepsis., [RefSeq, PubMed]; Inhibition of RRM2 radiosensitizes glioblastoma and uncovers synthetic lethality in combination with targeting CHK1., [RefSeq, PubMed]; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI23;Q542E2", "ec_number_list": "1.17.4.1", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;GO:0008199 ferric iron binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005971 ribonucleoside-diphosphate reductase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0008284 positive regulation of cell population proliferation;GO:0051290 protein heterotetramerization;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0009263 deoxyribonucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P11157-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F6YCR7-1", "uniprot_id": "RHX13_MOUSE", "mass": 25316.0, "length": 232, "protein_name": "Homeobox protein Rhox13", "gene_name": "Rhox13", "organism": "Mouse", "refseq_name": "homeobox protein Rhox13", "refseq_ac": "NP_001171931", "gene_names_uniprotkb": "Rhox13", "gene_names_refseq": "1700123J19Rik; Rhox13", "protein_names_uniprotkb": "Homeobox protein Rhox13; Reproductive homeobox protein 13", "protein_names_refseq": "homeobox protein Rhox13; novel homeobox domain-containing protein; reproductive homeobox protein 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:73614)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18675325;22190708;27486269", "class_list": "", "function": "Probable transcription factor., [UniProtKB]; RHOX13 is not essential for mouse fertility in a controlled laboratory setting, but that it is required for optimal development of differentiating germ cells and progression of the first wave of spermatogenesis, [RefSeq, PubMed]; Results strongly suggest that RHOX13 expression is regulated at a posttranscriptional step by direct interaction of NANOS2 with Rhox13 mRNA to suppress translation. Publication Status: Online-Only, [RefSeq, PubMed]; The Rhox13 gene encodes a 25.3 kDa protein expressed in the adult testis in germ cells at the basal aspect of the seminiferous epithelium., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C1Q7", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0071300 cellular response to retinoic acid;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F6YCR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3XA57-1", "uniprot_id": "RFIP2_MOUSE", "mass": 58207.0, "length": 512, "protein_name": "Rab11 family-interacting protein 2", "gene_name": "Rab11fip2", "organism": "Mouse", "refseq_name": "rab11 family-interacting protein 2 isoform 1", "refseq_ac": "NP_001028344", "gene_names_uniprotkb": "Rab11fip2", "gene_names_refseq": "4930470G04Rik; A830046J09Rik; Nrip11; Rab11fip2", "protein_names_uniprotkb": "Rab11 family-interacting protein 2; Rab11-FIP2", "protein_names_refseq": "rab11 family-interacting protein 2 isoform 1; rab11 family-interacting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74998); (R-MMU-432040)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12364336;19335615;20534835;21750661;22645316;31599954;32848054;34678516", "class_list": "", "function": "A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics., [UniProtKB, PubMed, UniProtKB]; Data demonstrate that AMPH leads to an increase of NET in endosomes of single boutons and varicosities in a Rab11-dependent manner., [RefSeq, PubMed]; Rab11-FIP2 has a role in the coupling of receptor-mediated endocytosis to the subsequent sorting of receptor-containing vesicles in endosomes [RAB11-FIP2], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B9EID4;Q5HZI0", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0055038 recycling endosome membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway;GO:0043547 positive regulation of GTPase activity;GO:0045055 regulated exocytosis;GO:0006909 phagocytosis;GO:1903078 positive regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "G3XA57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09037-1", "uniprot_id": "REG3A_MOUSE", "mass": 19539.0, "length": 175, "protein_name": "Regenerating islet-derived protein 3-alpha", "gene_name": "Reg3a", "organism": "Mouse", "refseq_name": "regenerating islet-derived protein 3-alpha precursor", "refseq_ac": "NP_035389", "gene_names_uniprotkb": "Reg3a; Pap2", "gene_names_refseq": "Reg3a", "protein_names_uniprotkb": "Regenerating islet-derived protein 3-alpha; Islet of Langerhans regenerating protein 3; Lithostathine 3; Pancreatitis-associated protein 2; REG-3-alpha; Reg III-alpha; Regenerating islet-derived protein III-alpha", "protein_names_refseq": "REG-3-alpha; RegIII (alpha); generating islet-derived, mouse homolog 3 alpha; islet of Langerhans regenerating protein 3; lithostathine 3; pancreatitis-associated protein 2; reg III-alpha; regenerating islet-derived protein 3-alpha precursor; regenerating islet-derived protein 3-alpha; regenerating islet-derived protein III-alpha", "tax_id": 10090, "disease": "acute pancreatitis (Disease Ontology:DOID:2913); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:19694); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19343564;20382864;21410322;22727489;25938566;28774595;36240759;9055810", "class_list": "glycogene", "function": "Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway (By similarity). In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF (PubMed:22727489). In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation (PubMed:36240759)., [UniProtKB, PubMed, PubMed, UniProtKB]; Bactericidal C-type lectin. The lack of the EPN motif may explain its inability to bind peptidoglycan., [UniProtKB, PubMed]; Reg2, Reg3alpha, and Reg3beta were abundantly expressed in most acinar cells of the pancreas with clear age-dependent and isoform-specific patterns., [RefSeq, PubMed]; Reg3alpha is an extracellular matrix-targeted reactive oxygen species scavenger that binds the fibrin scaffold resulting from hepatocyte death during acute liver failure. Publication Status: Online-Only, [RefSeq, PubMed]; Reg3alpha stimulates beta-cell replication, by activating Akt kinase and increasing the levels of cyclin D1/CDK4., [RefSeq, PubMed]; Skin injury increases IL-36gamma via the activation of TLR3-SLUG-VDR axis and IL-36gamma induces REG3A to promote wound healing, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045617 negative regulation of keratinocyte differentiation;GO:0008284 positive regulation of cell population proliferation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O09037-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09049-1", "uniprot_id": "REG3G_MOUSE", "mass": 19307.0, "length": 174, "protein_name": "Regenerating islet-derived protein 3-gamma", "gene_name": "Reg3g", "organism": "Mouse", "refseq_name": "regenerating islet-derived protein 3-gamma preproprotein", "refseq_ac": "NP_035390", "gene_names_uniprotkb": "Reg3g; Pap3", "gene_names_refseq": "REG-3-gamma; Reg3g; reg III-gamma", "protein_names_uniprotkb": "Regenerating islet-derived protein 3-gamma; Pancreatitis-associated protein 3; REG-3-gamma; Reg III-gamma; Regenerating islet-derived protein III-gamma", "protein_names_refseq": "generating islet-derived, mouse homolog 3 gamma; pancreatitis-associated protein 3; regenerating islet-derived protein 3-gamma preproprotein; regenerating islet-derived protein 3-gamma; regenerating islet-derived protein III-gamma", "tax_id": 10090, "disease": "", "pathway": " (mmu:19695); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "16504538;16931762;17635956;19095652;21998396;22727489;23401489;27830702;28811323;35263589;36240758;38358358;9055810", "class_list": "glycogene", "function": "Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways (PubMed:22727489, PubMed:27830702, PubMed:36240758). Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury (PubMed:22727489). In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF (PubMed:27830702). Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation (PubMed:28811323). Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents (PubMed:36240758). Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia (PubMed:35263589)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Antibacterial activities of mouse RegIIIgamma and its human ortholog, HIP/PAP, are tightly controlled by an inhibitory N-terminal prosegment that is removed by trypsin in vivo., [RefSeq, PubMed]; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Findings show that RegIIIgamma and its human counterpart, HIP/PAP, are directly antimicrobial proteins that bind their bacterial targets via interactions with peptidoglycan carbohydrate, [RefSeq, PubMed]; Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus., [UniProtKB, PubMed]; Has bacteriostatic activity., [UniProtKB, PubMed]; Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine., [RefSeq, PubMed]; This gene encodes a C-type lectin that demonstrates bactericidal activity. This gene is predominantly expressed in the distal small intestine where the encoded protein undergoes proteolytic processing by trypsin. Mice lacking the encoded protein exhibit altered mucus distribution, increased bacterial contact with the epithelium, and elevated inflammatory markers in the ileum, and low-grade inflammation. [provided by RefSeq, Jun 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0042834 peptidoglycan binding;GO:0046872 metal ion binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0031012 extracellular matrix", "go_biological_process": "GO:0009609 response to symbiotic bacterium;GO:0045617 negative regulation of keratinocyte differentiation;GO:0008284 positive regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O09049-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34057-1", "uniprot_id": "RECO_MOUSE", "mass": 23407.0, "length": 202, "protein_name": "Recoverin", "gene_name": "Rcvrn", "organism": "Mouse", "refseq_name": "recoverin", "refseq_ac": "NP_033064", "gene_names_uniprotkb": "Rcvrn; Rcv1", "gene_names_refseq": "CAR; Rcvrn; S-modulin", "protein_names_uniprotkb": "Recoverin; 23 kDa photoreceptor cell-specific protein; Cancer-associated retinopathy protein; Protein CAR", "protein_names_refseq": "23 kDa photoreceptor cell-specific protein; cancer-associated retinopathy protein; guanylate cyclase activator; recoverin", "tax_id": 10090, "disease": "", "pathway": " (mmu:19674); (R-MMU-2514859)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "1386025;15882641;15961391;25673692;28151698;29435986;30635390", "class_list": "", "function": "Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (PubMed:25673692). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (PubMed:15882641). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (PubMed:29435986)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0030425 dendrite;GO:0043204 perikaryon;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0051924 regulation of calcium ion transport;GO:0007601 visual perception;GO:0009966 regulation of signal transduction;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P34057-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35546-1", "uniprot_id": "RET_MOUSE", "mass": 123874.0, "length": 1115, "protein_name": "Proto-oncogene tyrosine-protein kinase receptor Ret", "gene_name": "Ret", "organism": "Mouse", "refseq_name": "proto-oncogene tyrosine-protein kinase receptor Ret isoform c precursor", "refseq_ac": "NP_001074249", "gene_names_uniprotkb": "Ret", "gene_names_refseq": "PTC; RET51; RET9; Ret; c-Ret", "protein_names_uniprotkb": "Proto-oncogene tyrosine-protein kinase receptor Ret; 2.7.10.1; Proto-oncogene c-Ret", "protein_names_refseq": "proto-oncogene c-Ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform c precursor; proto-oncogene tyrosine-protein kinase receptor Ret", "tax_id": 10090, "disease": "multiple endocrine neoplasia type 2A (Disease Ontology:DOID:0050430); familial medullary thyroid carcinoma (Disease Ontology:DOID:0050547); pheochromocytoma (Disease Ontology:DOID:0050771); renal hypoplasia (Disease Ontology:DOID:0080204); Parkinsonism (Disease Ontology:DOID:0080855); multiple endocrine neoplasia type 2B (Disease Ontology:DOID:10016); Hirschsprung's disease (Disease Ontology:DOID:10487); clubfoot (Disease Ontology:DOID:11836); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (mmu:19713); (R-MMU-5673001); (R-MMU-8853659)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;11470823;14607833;15242795;17050626;17322904;18753381;20237269;21134556;21612845;28846099;28953886;29144449;33300544;8455936;8631863", "class_list": "", "function": "Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:17322904, PubMed:20237269, PubMed:28846099). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (PubMed:17322904, PubMed:20237269, PubMed:28846099). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:17322904, PubMed:28846099). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (PubMed:20237269). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (PubMed:17322904). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846099). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (By similarity). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (By similarity). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (By similarity). Involved in the development of the neural crest (PubMed:15242795). Regulates nociceptor survival and size (PubMed:20237269). Phosphorylates PTK2/FAK1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 11, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQ34;Q9QXH9", "ec_number_list": "2.7.12.2;2.7.10.1;3.2.1.31;2.7.12.1;2.7.1.153;2.7.1.137;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;2.7.11.11;3.6.5.2;2.7.11.17;3.1.3.48;2.7.11.13;2.7.10.4;2.7.1.40;2.7.11.23;3.1.4.11;1.2.1.36;2.7.11.24", "go_molecular_function": "GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0060384 innervation;GO:0048484 enteric nervous system development;GO:0001838 embryonic epithelial tube formation;GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P35546-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47932-1", "uniprot_id": "REL1_MOUSE", "mass": 20571.0, "length": 185, "protein_name": "Prorelaxin 1", "gene_name": "Rln1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rln1; Rln; Rlx", "gene_names_refseq": "", "protein_names_uniprotkb": "Prorelaxin 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-418555); (R-MMU-444821)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "8216305;8452637", "class_list": "", "function": "Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0060443 mammary gland morphogenesis;GO:0007283 spermatogenesis;GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P47932-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52651-1", "uniprot_id": "RHOX5_MOUSE", "mass": 23045.0, "length": 210, "protein_name": "Homeobox protein Rhox5", "gene_name": "Rhox5", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rhox5; Pem", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Rhox5; Homeobox protein Pem; Placenta and embryonic expression protein; Reproductive homeobox on chromosome X 5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "1676380;1680379;21750661;2210045;24074865;28135057", "class_list": "", "function": "Transcription factor required for differentiation of embryonic stem cells (ESCs) into primordial germ cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030317 flagellated sperm motility;GO:0045893 positive regulation of DNA-templated transcription;GO:0035234 ectopic germ cell programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P52651-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58801-1", "uniprot_id": "RIPK2_MOUSE", "mass": 60400.0, "length": 539, "protein_name": "Receptor-interacting serine/threonine-protein kinase 2", "gene_name": "Ripk2", "organism": "Mouse", "refseq_name": "receptor-interacting serine/threonine-protein kinase 2 isoform 1", "refseq_ac": "NP_620402", "gene_names_uniprotkb": "Ripk2; Rip2", "gene_names_refseq": "2210420D18Rik; CARD3; CARDIAK; CCK; D4Bwg0615e; RICK; RIP2; Ripk2", "protein_names_uniprotkb": "Receptor-interacting serine/threonine-protein kinase 2; 2.7.10.2; 2.7.11.1; Receptor-interacting protein 2; Tyrosine-protein kinase RIPK2", "protein_names_refseq": "receptor-interacting protein 2; receptor-interacting serine/threonine-protein kinase 2 isoform 1; receptor-interacting serine/threonine-protein kinase 2; tyrosine-protein kinase RIPK2", "tax_id": 10090, "disease": "", "pathway": " (mmu:192656); (R-MMU-168638); (R-MMU-202424); (R-MMU-209543); (R-MMU-450302); (R-MMU-450321); (R-MMU-5689896)", "pathway_count": 7, "publication_count": 18, "publication_id_list": "11894097;17187069;17277144;17947236;17965022;19473975;21183079;21469090;21750661;23892723;24788674;26646181;30084848;30405132;37121674;37777791;38064597;38729551", "class_list": "", "function": "LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive Disorder Model via RIP2 Expression through ROS-NOD2 Induction., [RefSeq, PubMed]; Pharmacological inhibition of receptor-interacting protein kinase 2 (RIPK2) elicits neuroprotective effects following experimental ischemic stroke., [RefSeq, PubMed]; Receptor-interacting protein kinase 2 (RIPK2) profoundly contributes to post-stroke neuroinflammation and behavioral deficits with microglia as unique perpetrators. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses (By similarity). Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments (PubMed:17277144, PubMed:21469090, PubMed:30405132). Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3, as well as 'Met-1'-linked (linear) polyubiquitination by the LUBAC complex, becoming a scaffolding protein for downstream effectors (PubMed:30405132). 'Met-1'-linked polyubiquitin chains attached to RIPK2 recruit IKBKG/NEMO, which undergoes 'Lys-63'-linked polyubiquitination in a RIPK2-dependent process (By similarity). 'Lys-63'-linked polyubiquitin chains attached to RIPK2 serve as docking sites for TAB2 and TAB3 and mediate the recruitment of MAP3K7/TAK1 to IKBKG/NEMO, inducing subsequent activation of IKBKB/IKKB (PubMed:17965022). In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (By similarity). The protein kinase activity is dispensable for the NOD1 and NOD2 signaling pathways (By similarity). Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappa-B activation by NOD2 (By similarity). Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (By similarity). Plays a role in the inactivation of RHOA in response to NGFR signaling (PubMed:26646181)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The Ubiquitination of RIPK2 is Mediated by Peli3 and Negatively Regulates the Onset of Infectious Osteomyelitis., [RefSeq, PubMed]; This gene encodes a member of the receptor-interacting protein family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain, and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of nuclear factor kappa B and inducer of apoptosis in response to various stimuli. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.3.2.27;2.7.11.24;2.7.12.2;2.7.10.1;2.7.12.1;2.7.11.22;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.10.4;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.3.2.23;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.2.-;3.4.19.12;2.3.1.48;4.1.1.32;2.3.2.26;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0097039 protein linear polyubiquitination;GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P58801-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60191-1", "uniprot_id": "RIMS4_MOUSE", "mass": 29329.0, "length": 269, "protein_name": "Regulating synaptic membrane exocytosis protein 4", "gene_name": "Rims4", "organism": "Mouse", "refseq_name": "regulating synaptic membrane exocytosis protein 4 isoform 1", "refseq_ac": "NP_898844", "gene_names_uniprotkb": "Rims4", "gene_names_refseq": "6530406L02; Rim4; Rims4", "protein_names_uniprotkb": "Regulating synaptic membrane exocytosis protein 4; RIM 4; RIM4 gamma; Rab3-interacting molecule 4", "protein_names_refseq": "RIM 4; RIM4 gamma; rab3-interacting molecule 4; regulating synaptic membrane exocytosis protein 4 isoform 1; regulating synaptic membrane exocytosis protein 4", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:241770)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12620390;21183079;38478593", "class_list": "", "function": "Paroxysmal dystonia results from the loss of RIM4 in Purkinje cells., [RefSeq, PubMed]; Regulates synaptic membrane exocytosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0045202 synapse;GO:0097060 synaptic membrane", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0006887 exocytosis;GO:0050807 regulation of synapse organization;GO:0006836 neurotransmitter transport;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P60191-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63032-1", "uniprot_id": "RHES_MOUSE", "mass": 30197.0, "length": 266, "protein_name": "GTP-binding protein Rhes", "gene_name": "Rasd2", "organism": "Mouse", "refseq_name": "GTP-binding protein Rhes", "refseq_ac": "NP_083458", "gene_names_uniprotkb": "Rasd2", "gene_names_refseq": "4930526B11Rik; Rasd2; Rhes; TEM-2; TEM2", "protein_names_uniprotkb": "GTP-binding protein Rhes; Ras homolog enriched in striatum", "protein_names_refseq": "GTP-binding protein Rhes; ras homolog enriched in striatum", "tax_id": 10090, "disease": "", "pathway": " (mmu:75141)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15199135;16945334;18035555;18585460;18845937;36566472", "class_list": "", "function": "GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G protein-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination., [UniProtKB, PubMed, PubMed]; Rasd2 Mediates Acute Fasting-Induced Antidepressant-Like Effects via Dopamine D2 Receptor Activation in Ovariectomized Mice. Erratum:[Int J Neuropsychopharmacol. 2023 Apr 17;26(4):307. doi: 10.1093/ijnp/pyad015. PMID: 37002955], [RefSeq, PubMed]; Rhes disruption affects selected behavioral competencies, including a gender-dependent increase in anxiety levels and a clear motor coordination deficit but no learning or memory impairment., [RefSeq, PubMed]; The absence of Rhes modulates cAMP/PKA signalling in both striatopallidal and striatonigral projection neurons by increasing Golf protein levels and, in turn, influencing motor responses challenged by dopaminergic agonist/antagonist., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WVD3", "ec_number_list": "", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0031624 ubiquitin conjugating enzyme binding;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0007626 locomotory behavior;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0001963 synaptic transmission, dopaminergic;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P63032-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00915-1", "uniprot_id": "RET1_MOUSE", "mass": 15846.0, "length": 135, "protein_name": "Retinol-binding protein 1", "gene_name": "Rbp1", "organism": "Mouse", "refseq_name": "retinol-binding protein 1", "refseq_ac": "NP_035384", "gene_names_uniprotkb": "Rbp1; Crbpi; Rbp-1", "gene_names_refseq": "CRBPI; Crbp; Rbp-1; Rbp1", "protein_names_uniprotkb": "Retinol-binding protein 1; CRBP-I; CRBP; Cellular retinol-binding protein I; Cellular retinol-binding protein; mCRBPI", "protein_names_refseq": "CRBP-I; cellular retinol-binding protein I; mCRBPI; retinol-binding protein 1", "tax_id": 10090, "disease": "multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:19659); (R-MMU-2453902); (R-MMU-975634)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10487743;15632377;1648481;22665496;25428506;26030625;30084848", "class_list": "", "function": "Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0005501 retinoid binding;GO:1904768 all-trans-retinol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0030852 regulation of granulocyte differentiation;GO:0001523 retinoid metabolic process;GO:0055088 lipid homeostasis;GO:0042572 retinol metabolic process;GO:0042573 retinoic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q00915-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3KNY5-1", "uniprot_id": "RIAD1_MOUSE", "mass": 13797.0, "length": 119, "protein_name": "RIIa domain-containing protein 1", "gene_name": "Riiad1", "organism": "Mouse", "refseq_name": "RIIa domain-containing protein 1 isoform 1", "refseq_ac": "NP_079782", "gene_names_uniprotkb": "Riiad1", "gene_names_refseq": "2310007A19Rik; Ncrna00166; Riiad1", "protein_names_uniprotkb": "RIIa domain-containing protein 1", "protein_names_refseq": "RIIa domain-containing protein 1 isoform 1; RIIa domain-containing protein 1; RIIa domain-containing protein C1orf230 homolog", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "17971504", "class_list": "", "function": "2310007A19Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7J0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KNY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VEE4-1", "uniprot_id": "RFA1_MOUSE", "mass": 69037.0, "length": 623, "protein_name": "Replication protein A 70 kDa DNA-binding subunit", "gene_name": "Rpa1", "organism": "Mouse", "refseq_name": "replication protein A 70 kDa DNA-binding subunit isoform 1", "refseq_ac": "NP_001157695", "gene_names_uniprotkb": "Rpa1", "gene_names_refseq": "5031405K23Rik; 70kDa; RF-A; RP-A; Rpa1; Rpa", "protein_names_uniprotkb": "Replication protein A 70 kDa DNA-binding subunit; RF-A protein 1; RP-A p70; Replication factor A protein 1", "protein_names_refseq": "RF-A protein 1; RP-A p70; replication factor A protein 1; replication protein A 70 kDa DNA-binding subunit isoform 1; replication protein A 70 kDa DNA-binding subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:68275); (R-MMU-110312); (R-MMU-110314); (R-MMU-110320); (R-MMU-174437); (R-MMU-176187); (R-MMU-3108214); (R-MMU-3371453); (R-MMU-5358565); (R-MMU-5358606); (R-MMU-5651801); (R-MMU-5655862); (R-MMU-5656121); (R-MMU-5656169); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693607); (R-MMU-5696395); (R-MMU-5696397); (R-MMU-5696400); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6783310); (R-MMU-6804756); (R-MMU-68962); (R-MMU-69166); (R-MMU-69473)", "pathway_count": 28, "publication_count": 15, "publication_id_list": "21750661;21952136;23806337;25428506;25605945;30084848;30779550;31219806;31467087;34428180;36210013;37507081;37828378;38000394;39627609", "class_list": "", "function": "As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEJ8", "ec_number_list": "", "go_molecular_function": "GO:0098505 G-rich strand telomeric DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000793 condensed chromosome;GO:0001673 male germ cell nucleus", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0001701 in utero embryonic development;GO:0006281 DNA repair;GO:0008284 positive regulation of cell population proliferation;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8VEE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60990-1", "uniprot_id": "RBY1B_MOUSE", "mass": 43143.0, "length": 380, "protein_name": "RNA-binding motif protein, Y chromosome, family 9", "gene_name": "Rbmyf9", "organism": "Mouse", "refseq_name": "RNA-binding motif protein, Y chromosome, family 9", "refseq_ac": "NP_001257441", "gene_names_uniprotkb": "Rbmyf9; Gm3376; Rbmy1b; Rbm", "gene_names_refseq": "100041505; Gm3376; Rbmy1b; Rbmyf9", "protein_names_uniprotkb": "RNA-binding motif protein, Y chromosome, family 9; RNA-binding motif protein 1; RNA-binding motif protein, Y chromosome, family 1 member B", "protein_names_refseq": "RNA binding motif protein, Y chromosome, family 1 member; RNA-binding motif protein 1; RNA-binding motif protein, Y chromosome, family 9; rNA-binding motif protein, Y chromosome, family 1 member B", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041505)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12356914;15051956;8817321", "class_list": "", "function": "RNA-binding protein which may be involved in spermatogenesis (By similarity). May be required for sperm development, possibly by participating in pre-mRNA splicing in the testis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q2F9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q60990-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BRE0-1", "uniprot_id": "RD3_MOUSE", "mass": 22669.0, "length": 195, "protein_name": "Protein RD3", "gene_name": "Rd3", "organism": "Mouse", "refseq_name": "protein RD3 isoform 2", "refseq_ac": "NP_001171371", "gene_names_uniprotkb": "Rd3", "gene_names_refseq": "3322402L07Rik; Rd3; rd-3", "protein_names_uniprotkb": "Protein RD3; Retinal degeneration protein 3", "protein_names_refseq": "protein RD3 isoform 2; protein RD3; retinal degeneration protein 3", "tax_id": 10090, "disease": "Leber congenital amaurosis 12 (Disease Ontology:DOID:0110080); Leber congenital amaurosis (Disease Ontology:DOID:14791); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:74023)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10679242;12914764;17186464;21078983;27471269;29515371;33539922;34537244;8486383", "class_list": "", "function": "Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors (PubMed:21078983, PubMed:27471269). Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors (PubMed:27471269). Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment (PubMed:21078983). Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP (By similarity). Plays an important role for the survival of rods and cones in the retina (PubMed:17186464, PubMed:8486383)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase., [RefSeq, PubMed]; Retinal degeneration-3 protein promotes photoreceptor survival by suppressing activation of guanylyl cyclase rather than accelerating GMP recycling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYJ8;Q9CRS3;Q9JMF2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0048471 perinuclear region of cytoplasm;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0031283 negative regulation of guanylate cyclase activity;GO:0015031 protein transport;GO:0007601 visual perception;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BRE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYP3-1", "uniprot_id": "RHOF_MOUSE", "mass": 23577.0, "length": 211, "protein_name": "Rho-related GTP-binding protein RhoF", "gene_name": "Rhof", "organism": "Mouse", "refseq_name": "rho-related GTP-binding protein RhoF", "refseq_ac": "NP_780301", "gene_names_uniprotkb": "Rhof; Arhf", "gene_names_refseq": "Arhf; Ifld1; Rhof; Rif", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoF; 3.6.5.2", "protein_names_refseq": "induced in fatty liver dystrophy 1; ras homolog gene family, member f (in filopodia); rho-related GTP-binding protein RhoF", "tax_id": 10090, "disease": "", "pathway": " (mmu:23912); (R-MMU-6798695); (R-MMU-9035034)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21339294;23359340;25428506;30998758", "class_list": "", "function": "Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology (By similarity)., [UniProtKB]; RHOF is required for NFkappaB activation by KLF4 in esophageal keratinocytes and is also important for esophageal keratinocyte proliferation and migration. Publication Status: Online-Only, [RefSeq, PubMed]; Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors., [RefSeq, PubMed]; Small GTPase Rif does not appear to be critical for platelet function in mice. Functional overlap between Rif and other small GTPases may be responsible for the non-essential role of Rif in platelets, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.1.3.48;3.6.5.4;2.4.1.-;2.4.1.275;2.4.1.22;2.4.1.38;2.4.1.90;3.6.5.5;3.4.22.-;3.6.4.-;3.4.11.2;3.6.1.-;3.6.1.15;2.7.11.1;7.6.2.-;3.4.24.11;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;3.6.-.-;1.16.1.-;3.1.3.-;3.1.3.95", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BYP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHK2-1", "uniprot_id": "REL3_MOUSE", "mass": 14926.0, "length": 141, "protein_name": "Relaxin-3", "gene_name": "Rln3", "organism": "Mouse", "refseq_name": "relaxin-3 precursor", "refseq_ac": "NP_775276", "gene_names_uniprotkb": "Rln3; Insl7", "gene_names_refseq": "M3; Rln3; insl7", "protein_names_uniprotkb": "Relaxin-3; Insulin-like peptide 7; Insulin-like peptide INSL7; Prorelaxin M3", "protein_names_refseq": "insulin-like 7; insulin-like peptide 7; insulin-like peptide INSL7; prorelaxin M3; relaxin-3 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:212108); (R-MMU-418555); (R-MMU-418594); (R-MMU-444821)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11689565;12686464;28100033;33055197", "class_list": "", "function": "Mapping Cell Types and Efferent Pathways in the Ascending Relaxin-3 System of the Nucleus Incertus. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity)., [UniProtKB]; Results indicate endogenous RLN3/RXFP3 signaling can modulate hippocampal-dependent spatial reference and working memory via effects on somatostatin interneurons, and further our knowledge of hippocampal cognitive processing, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CHK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2J7-1", "uniprot_id": "RELL1_MOUSE", "mass": 29351.0, "length": 272, "protein_name": "RELT-like protein 1", "gene_name": "Rell1", "organism": "Mouse", "refseq_name": "RELT-like protein 1 isoform a precursor", "refseq_ac": "NP_666035", "gene_names_uniprotkb": "Rell1", "gene_names_refseq": "Rell1", "protein_names_uniprotkb": "RELT-like protein 1", "protein_names_refseq": "RELT-like protein 1 isoform a precursor; RELT-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100532)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;32090861;34428180", "class_list": "", "function": "Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed., [UniProtKB, UniProtKB]; RELL1 inhibits autophagy pathway and regulates Mycobacterium tuberculosis survival in macrophages., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVW8;Q3UZH6;Q8R3S5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:1900745 positive regulation of p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K2J7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K426-1", "uniprot_id": "RETNG_MOUSE", "mass": 12535.0, "length": 117, "protein_name": "Resistin-like gamma", "gene_name": "Retnlg", "organism": "Mouse", "refseq_name": "resistin-like gamma precursor", "refseq_ac": "NP_853627", "gene_names_uniprotkb": "Retnlg; Xcp1", "gene_names_refseq": "Fizz3; Relmg; Retnlg; Xcp1", "protein_names_uniprotkb": "Resistin-like gamma; RELMgamma; Resistin-like molecule gamma; Ten-cysteine protein 1; XCP1", "protein_names_refseq": "RELMgamma; resistin-like gamma precursor; resistin-like molecule gamma; ten-cysteine protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:245195)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12782128;14733912;15064728;15834545;25428506", "class_list": "", "function": "Probable hormone (Probable). Promotes chemotaxis in myeloid cells (PubMed:15064728)., [UniProtKB, PubMed]; RELMgamma is a secreted molecule with a restricted expression pattern that may play a role in promyelocytic differentiation, [RefSeq, PubMed]; Serum concentrations of RELMbeta and RELMgamma may be a novel intestinal-tract-mediating regulator of insulin sensitivity, possibly involved in insulin resistance induced by obesity and a high-fat diet., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TM98", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002408 myeloid dendritic cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K426-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K443-1", "uniprot_id": "RGS13_MOUSE", "mass": 18729.0, "length": 158, "protein_name": "Regulator of G protein signaling 13", "gene_name": "Rgs13", "organism": "Mouse", "refseq_name": "regulator of G-protein signaling 13", "refseq_ac": "NP_694811", "gene_names_uniprotkb": "Rgs13", "gene_names_refseq": "Rgs13", "protein_names_uniprotkb": "Regulator of G protein signaling 13; RGS13", "protein_names_refseq": "regulator of G-protein signaling 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:246709); (R-MMU-416476); (R-MMU-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12193720;21531726", "class_list": "", "function": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha., [UniProtKB]; P53 may modulate immune responses through suppression of RGS13 transcription in mast cells and B cells, [RefSeq, PubMed]; Rgs13 is strongly expressed in the germinal center regions of spleen, Peyer's patches, and thymic medulla, interacts with Gialpha and Gqalpha, and strongly inhibits both CXCL12- and CXCL13-induced signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K443-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R1Q9-1", "uniprot_id": "RBSK_MOUSE", "mass": 34119.0, "length": 323, "protein_name": "Ribokinase", "gene_name": "Rbks", "organism": "Mouse", "refseq_name": "ribokinase isoform 1", "refseq_ac": "NP_694876", "gene_names_uniprotkb": "Rbks; Rbsk", "gene_names_refseq": "5230400M11Rik; RBSK; RK; Rbks", "protein_names_uniprotkb": "Ribokinase; 2.7.1.15; RK", "protein_names_refseq": "ribokinase isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71336); (R-MMU-71336)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.15", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0004747 ribokinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006098 pentose-phosphate shunt;GO:0019303 D-ribose catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8R1Q9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDU1-1", "uniprot_id": "RHOV_MOUSE", "mass": 26148.0, "length": 236, "protein_name": "Rho-related GTP-binding protein RhoV", "gene_name": "Rhov", "organism": "Mouse", "refseq_name": "rho-related GTP-binding protein RhoV", "refseq_ac": "NP_663505", "gene_names_uniprotkb": "Rhov", "gene_names_refseq": "A030005A06Rik; Arhv; Rhov", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoV; 3.6.5.2", "protein_names_refseq": "ras homolog gene family, member V; rho-related GTP-binding protein RhoV", "tax_id": 10090, "disease": "", "pathway": " (mmu:228543); (R-MMU-9013424)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;2.7.11.1;3.6.5.4;3.6.5.5;3.4.19.12;3.6.1.-;2.7.10.1;3.6.1.15;2.3.2.27;2.7.11.25;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VDU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V81-1", "uniprot_id": "RBM42_MOUSE", "mass": 50236.0, "length": 478, "protein_name": "RNA-binding protein 42", "gene_name": "Rbm42", "organism": "Mouse", "refseq_name": "RNA-binding protein 42", "refseq_ac": "NP_598454", "gene_names_uniprotkb": "Rbm42", "gene_names_refseq": "1700003D06Rik; 3100004P22Rik; Rbm42", "protein_names_uniprotkb": "RNA-binding protein 42; RNA-binding motif protein 42", "protein_names_refseq": "RNA-binding protein 42", "tax_id": 10090, "disease": "", "pathway": " (mmu:68035); (R-MMU-72163)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "19170760;21183079;21750661;31219806;34203471;34428180;36210013", "class_list": "", "function": "Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBE0", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome;GO:0046540 U4/U6 x U5 tri-snRNP complex;GO:0005634 nucleus", "go_biological_process": "GO:0048025 negative regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91V81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V93-1", "uniprot_id": "RHBT2_MOUSE", "mass": 82650.0, "length": 728, "protein_name": "Rho-related BTB domain-containing protein 2", "gene_name": "Rhobtb2", "organism": "Mouse", "refseq_name": "rho-related BTB domain-containing protein 2", "refseq_ac": "NP_705734", "gene_names_uniprotkb": "Rhobtb2; Dbc2", "gene_names_refseq": "Dbc2; E130206H14Rik; Rhobtb2; mKIAA0717", "protein_names_uniprotkb": "Rho-related BTB domain-containing protein 2; 3.6.5.2; Deleted in breast cancer 2 gene protein homolog", "protein_names_refseq": "deleted in breast cancer 2 gene protein homolog; rho-related BTB domain-containing protein 2", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 64 (Disease Ontology:DOID:0070375)", "pathway": " (mmu:246710); (R-MMU-9013418)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12370419;12426103;15567721;25428506;30084848;30779550", "class_list": "", "function": "Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation. Required for MSI2 ubiquitination and degradation., [UniProtKB, UniProtKB]; There is no connection between elevated expression of mDbc2/Rhobtb2 and a specific stage of mammary gland development, but this gene plays a critical role in the development of the nervous system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYU3;Q8K1A8", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.4.10;3.6.5.4;3.6.5.5;3.6.4.-;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-;3.6.4.13", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0010008 endosome membrane;GO:0042995 cell projection", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0007264 small GTPase-mediated signal transduction;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91V93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99LE1-1", "uniprot_id": "RIPL2_MOUSE", "mass": 22393.0, "length": 197, "protein_name": "RILP-like protein 2", "gene_name": "Rilpl2", "organism": "Mouse", "refseq_name": "RILP-like protein 2", "refseq_ac": "NP_084535", "gene_names_uniprotkb": "Rilpl2", "gene_names_refseq": "Rilpl2", "protein_names_uniprotkb": "RILP-like protein 2; Rab-interacting lysosomal-like protein 2", "protein_names_refseq": "RILP-like protein 2; rab-interacting lysosomal-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:80291)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19812310;22872234;23264467;23798443;31175157;31219806;34428180;36210013", "class_list": "", "function": "Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (PubMed:23264467). May function via activation of RAC1 and PAK1 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Propose that Rab36 stimulates RILPL2 to interact with the myosin-5a globular tail domain (GTD); this interaction then induces exposure of the melanophilin-binding site in the GTD, enabling melanophilin to interact with the GTD and activate myosin-5a motor activity, [RefSeq, PubMed]; The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content by promoting protein removal from the primary cilium., [RefSeq, PubMed]; These data represent a novel mechanism linking RILPL2, the motor protein MyoVa and Rac1 with neuronal structure and function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB73", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0031267 small GTPase binding;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0060271 cilium assembly;GO:0003382 epithelial cell morphogenesis;GO:1903445 protein transport from ciliary membrane to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99LE1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQU3-1", "uniprot_id": "RER1_MOUSE", "mass": 22988.0, "length": 196, "protein_name": "Protein RER1", "gene_name": "Rer1", "organism": "Mouse", "refseq_name": "protein RER1", "refseq_ac": "NP_080671", "gene_names_uniprotkb": "Rer1", "gene_names_refseq": "1110060F11Rik; 5830454N22Rik; Rer1", "protein_names_uniprotkb": "Protein RER1", "protein_names_refseq": "RER1 retention in endoplasmic reticulum 1 homolog; protein RER1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67830)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17242355;21183079;21187406;28117367;30084848;30260951;30779550;34428180;37453647", "class_list": "", "function": "Involved in the retention or retrieval of proteins localized in the endoplasmic reticulum from the early Golgi compartment, including the gamma-secretase complex subunit PEN-2 (PSENEN) (By similarity). Regulates intracellular trafficking of the gamma-secretase complex and amyloid-beta precursor protein (APP), thereby controlling their levels at the cell surface and influencing the release of amyloid-beta peptides generated through gamma-secretase mediated processing of APP (By similarity). During cerebral cortex and neural stem cell development, it is required to maintain sufficient expression and activity of gamma-secretase complex at the cell surface, modulating NOTCH processing and signaling (PubMed:30260951). In addition to its role in the control of protein trafficking, the RER1-dependent Golgi apparatus-endoplasmic reticulum retrieval system may regulate proteasomal degradation of alpha-synuclein (SNCA) (By similarity)., [UniProtKB, UniProtKB, PubMed]; Rer1 controls the assembly and transport of Nav1.1 and 1.6, the principal sodium channels responsible for recurrent firing, in Purkinje cells. Publication Status: Online-Only, [RefSeq, PubMed]; Rer1 is a functionally important unique factor that controls surface expression of muscle acetylcholine receptors by localizing unassembled alpha-subunits to the early secretory pathway, [RefSeq, PubMed]; Study in knockout mice and genetically modified human HAP1 cell line suggests that Rer1 maintains Notch signaling by maintaining sufficient expression of the gamma-secretase complex on the cell surface and regulating neural stem cell maintenance during cerebral cortex development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THP4", "ec_number_list": "", "go_molecular_function": "GO:0033130 acetylcholine receptor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006621 protein retention in ER lumen;GO:0071340 skeletal muscle acetylcholine-gated channel clustering", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9CQU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CYF5-1", "uniprot_id": "RCC1L_MOUSE", "mass": 49995.0, "length": 461, "protein_name": "RCC1-like G exchanging factor-like protein", "gene_name": "Rcc1l", "organism": "Mouse", "refseq_name": "RCC1-like G exchanging factor-like protein", "refseq_ac": "NP_291050", "gene_names_uniprotkb": "Rcc1l; Wbscr16", "gene_names_refseq": "5730496C04Rik; Rcc1l; Wbscr16", "protein_names_uniprotkb": "RCC1-like G exchanging factor-like protein; RCC1-like protein; Williams-Beuren syndrome chromosomal region 16 protein homolog", "protein_names_refseq": "RCC1 like; RCC1-like G exchanging factor-like protein; RCC1-like protein; Williams-Beuren syndrome chromosome region 16 homolog; williams-Beuren syndrome chromosomal region 16 protein homolog", "tax_id": 10090, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (mmu:94254)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28746876", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876). Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0008053 mitochondrial fusion;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0061668 mitochondrial ribosome assembly;GO:0180026 mitochondrial small ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CYF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0B8-1", "uniprot_id": "RIBC1_MOUSE", "mass": 44962.0, "length": 379, "protein_name": "RIB43A-like with coiled-coils protein 1", "gene_name": "Ribc1", "organism": "Mouse", "refseq_name": "RIB43A-like with coiled-coils protein 1", "refseq_ac": "NP_079936", "gene_names_uniprotkb": "Ribc1", "gene_names_refseq": "2610028I09Rik; Ribc1", "protein_names_uniprotkb": "RIB43A-like with coiled-coils protein 1", "protein_names_refseq": "RIB43A-like with coiled-coils protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66611)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25428506;37295417", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CS97", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D0B8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0V7-1", "uniprot_id": "RCAS1_MOUSE", "mass": 24319.0, "length": 213, "protein_name": "Receptor-binding cancer antigen expressed on SiSo cells", "gene_name": "Ebag9", "organism": "Mouse", "refseq_name": "receptor-binding cancer antigen expressed on SiSo cells", "refseq_ac": "NP_062353", "gene_names_uniprotkb": "Ebag9; Rcas1", "gene_names_refseq": "Ebag9; Rcas1", "protein_names_uniprotkb": "Receptor-binding cancer antigen expressed on SiSo cells; Cancer-associated surface antigen RCAS1; Estrogen receptor-binding fragment-associated gene 9 protein", "protein_names_refseq": "cancer-associated surface antigen RCAS1; estrogen receptor-binding fragment-associated gene 9 protein; receptor-binding cancer antigen expressed on SiSo cells", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometriosis (Disease Ontology:DOID:289); breast ductal carcinoma (Disease Ontology:DOID:3007); invasive ductal carcinoma (Disease Ontology:DOID:3008); uterine cancer (Disease Ontology:DOID:363); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (mmu:55960)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11374862;17114649;17242355;18630941;19030177;19144319;19445026;19620783;21183079;21750661;36734265", "class_list": "", "function": "EBAG9 is a tunable inhibitor of CTL-mediated adaptive immune response functions., [RefSeq, PubMed]; EBAG9 may have a role in promoting progression of bladder cancer, [RefSeq, PubMed]; EBAG9 promoted primary 4T1 mammary carcinoma growth and distant metastasis, and EBAG9 small interfering RNA exerted overt regression of tumor growth and metastasis, [RefSeq, PubMed]; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases., [UniProtKB]; RCAS1 increases cell morphological changes in murine fibroblasts by reducing p38 phosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VET4;Q3TVG2;Q3TWY4;Q9QYD0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0030141 secretory granule", "go_biological_process": "GO:0006915 apoptotic process;GO:0001913 T cell mediated cytotoxicity;GO:0090717 adaptive immune memory response involving T cells and B cells", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D0V7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3G9-1", "uniprot_id": "RHOH_MOUSE", "mass": 21324.0, "length": 191, "protein_name": "Rho-related GTP-binding protein RhoH", "gene_name": "Rhoh", "organism": "Mouse", "refseq_name": "rho-related GTP-binding protein RhoH", "refseq_ac": "NP_001074574", "gene_names_uniprotkb": "Rhoh; Arhh", "gene_names_refseq": "5830400A04Rik; Arhh; Rhoh", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoH; 3.6.5.2", "protein_names_refseq": "ras homolog gene family, member H; rho-related GTP-binding protein RhoH", "tax_id": 10090, "disease": "immunodeficiency 129 (Disease Ontology:DOID:0061094)", "pathway": " (mmu:74734); (R-MMU-9013407)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "15494435;17028588;17119112;18089848;18299400;19124738;19224205;19414807;20173027;20484733;21952136;25428506;26495903;30084848;30339851;30779550;34428180;34983288;36108062", "class_list": "", "function": "An antagonistic role of RhoH in regulation of cortical F-actin assembly and chemotaxis via suppressing Rac1 membrane targeting and activation in primary hematopoietic progenitor cells, is identified., [RefSeq, PubMed]; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils (By similarity). Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70 (PubMed:17028588). Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma., [RefSeq, PubMed]; Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils. Publication Status: Online-Only, [RefSeq, PubMed]; RhoH deficiency in mice induced TH17 polarization during effector T-cell differentiation, thereby inducing psoriasis-like chronic dermatitis, [RefSeq, PubMed]; RhoH is a critical regulator of thymocyte development and TCR signaling by mediating recruitment and activation of Zap70., [RefSeq, PubMed]; RhoH is important for pre-T-cell receptor and T-cell receptor signaling, [RefSeq, PubMed]; RhoH serves as a negative regulator of both growth and actin-based function of hematopoietic progenitor cells possibly via suppression of Rac-mediated signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;2.1.1.13;3.6.5.2;3.6.5.3;3.6.1.5;2.7.11.1;2.7.10.2;3.6.5.4;3.6.5.5;2.7.10.4;2.3.1.168;2.7.11.39;3.6.1.-;3.6.4.6;3.6.1.15;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0019210 kinase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0001772 immunological synapse", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0045576 mast cell activation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9D3G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8G5-1", "uniprot_id": "REG4_MOUSE", "mass": 18398.0, "length": 157, "protein_name": "Regenerating islet-derived protein 4", "gene_name": "Reg4", "organism": "Mouse", "refseq_name": "regenerating islet-derived protein 4 precursor", "refseq_ac": "NP_080604", "gene_names_uniprotkb": "Reg4", "gene_names_refseq": "2010002L15Rik; GISP; RELP; Reg4", "protein_names_uniprotkb": "Regenerating islet-derived protein 4; REG-4", "protein_names_refseq": "REG-4; regenerating islet-derived protein 4 precursor; regenerating islet-derived protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67709)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12819006;19834624;19900450;29850784;33899235;36274484;36293268", "class_list": "glycogene", "function": "Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity)., [UniProtKB]; Cardiomyocytes situated in close proximity to the infarcted region produce large amounts of Reg3b, Reg3g, and Reg4, thereby forming a chemokine gradient that might direct interstitial migration of MHCIIhi/Ly6Clo and MHC-IIlo/Ly6Clo macrophage subsets., [RefSeq, PubMed]; Cloning and characterization of human REG4/RELP, in addition to cloning of mouse Reg4., [RefSeq, PubMed]; Reg IV as an important modulator of gastrointestinal cell susceptibility to irradiation; hence, it is a potential target for adjunctive treatments for human colorectal cancer and other gastrointestinal malignancies., [RefSeq, PubMed]; Reg4 is amplified in the early stages of pancreatic cancer development Publication Status: Online-Only, [RefSeq, PubMed]; Reg4 protects against Salmonella infection-associated intestinal inflammation via adopting a calcium-dependent lectin-like domain., [RefSeq, PubMed]; Reg4 regulates pancreatic regeneration following pancreatitis via modulating the Notch signaling., [RefSeq, PubMed]; Upregulation of Reg IV and Hgf mRNAs by Intermittent Hypoxia via Downregulation of microRNA-499 in Cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS25;Q9D858", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:2001065 mannan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D8G5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQT3-1", "uniprot_id": "RHOU_MOUSE", "mass": 28354.0, "length": 261, "protein_name": "Rho-related GTP-binding protein RhoU", "gene_name": "Rhou", "organism": "Mouse", "refseq_name": "rho-related GTP-binding protein RhoU", "refseq_ac": "NP_598716", "gene_names_uniprotkb": "Rhou; Arhu; G28k; Wrch1", "gene_names_refseq": "2310026M05Rik; Arhu; CDC42L1; G28K; Rhou; WRCH-1; WRCH1; mG28K", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoU; 3.6.5.2; Rho GTPase-like protein ARHU; WRCH-1; Wnt-1 responsive Cdc42 homolog 1", "protein_names_refseq": "Ras-like protein member U; Wnt1 responsive Cdc42 homolog; ras homolog gene family, member U; rho GTPase-like protein ARHU; rho-related GTP-binding protein RhoU; wnt-1 responsive Cdc42 homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69581); (R-MMU-9013420)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11459829;14731133;16046391;18086875;30834544;31556874", "class_list": "", "function": "Binds to and activates protein kinase PAK1. Plays a role in the regulation of cell morphology, cytoskeletal organization and focal adhesion assembly during cell migration. Also stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound., [UniProtKB, UniProtKB]; Coupling our top hit with gain/loss-of-function genetics, interactome proteomics and tissue imaging, the authors show that RHOU, an atypical Rho, governs the cytoskeletal-junction dynamics that establish columnar shape and planar cell polarity in epidermal progenitors. Publication Status: Online-Only, [RefSeq, PubMed]; G28K was differentially expressed in the small intestines; interstitial cells of Cajal within the small intestine expressed mRNA for G28K; downregulated in the jejunum of W/W V mice., [RefSeq, PubMed]; Loss of RhoU function in the mouse gut epithelium increases RhoA activity and the level of phosphorylated myosin light chain-2. Rhou knockdown in the mouse gut causes cell hyperplasia., [RefSeq, PubMed]; Wrch-1 membrane association, subcellular localization, and biological activity are mediated by a novel membrane-targeting mechanism distinct from that of Cdc42 and other isoprenylated Rho family GTPases, [RefSeq, PubMed]; Wrch1 collaborates with FAK2 and Src in regulating cytoskeletal dynamics., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;2.7.11.1;3.6.5.4;3.6.5.5;3.4.19.12;3.6.1.-;2.7.10.1;3.6.1.15;3.6.-.-;2.3.2.26;2.7.10.2", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0002102 podosome", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EQT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERI6-1", "uniprot_id": "RDH14_MOUSE", "mass": 36366.0, "length": 334, "protein_name": "Retinol dehydrogenase 14", "gene_name": "Rdh14", "organism": "Mouse", "refseq_name": "retinol dehydrogenase 14", "refseq_ac": "NP_076186", "gene_names_uniprotkb": "Rdh14; Pan2", "gene_names_refseq": "3110030G19Rik; PAN2; Rdh14", "protein_names_uniprotkb": "Retinol dehydrogenase 14; 1.1.1.300; Alcohol dehydrogenase PAN2", "protein_names_refseq": "alcohol dehydrogenase PAN2; expressed sequence AW215439; retinol dehydrogenase 14", "tax_id": 10090, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (mmu:105014); (R-MMU-5365859)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;12226107;34428180", "class_list": "", "function": "Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-retinol. Has no activity towards steroids., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.300;1.1.1.21;1.1.1.372;1.1.1.54;1.1.1.184;1.1.1.-", "go_molecular_function": "GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0102354 11-cis-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0042572 retinol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ERI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0J1-1", "uniprot_id": "RECK_MOUSE", "mass": 106082.0, "length": 971, "protein_name": "Reversion-inducing cysteine-rich protein with Kazal motifs", "gene_name": "Reck", "organism": "Mouse", "refseq_name": "reversion-inducing cysteine-rich protein with Kazal motifs precursor", "refseq_ac": "NP_057887", "gene_names_uniprotkb": "Reck", "gene_names_refseq": "Reck; St15; mRECK", "protein_names_uniprotkb": "Reversion-inducing cysteine-rich protein with Kazal motifs; mRECK", "protein_names_refseq": "Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK); membrane-anchored glycoprotein RECK; reversion-inducing cysteine-rich protein with Kazal motifs precursor; suppression of tumorigenicity 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:53614); (R-MMU-163125)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11747814;15093608;26658478;28803732;33731436;34428180;34679210;35552394;37712427;9789069", "class_list": "", "function": "Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28803732). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:26658478, PubMed:28803732). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (By similarity). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (By similarity). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:11747814). Also inhibits metalloproteinase activity of MMP2, MMP14 (MT1-MMP) and ADAM10 (PubMed:11747814, PubMed:33731436)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; MicroRNA expression in lung tissues of asbestos-exposed mice: Upregulation of miR-21 and downregulation of tumor suppressor genes Pdcd4 and Reck., [RefSeq, PubMed]; Oncogenic ras represses RECK expression via a histone deacetylation mechanism., [RefSeq, PubMed]; Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B1AWM3", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0015026 coreceptor activity;GO:0004866 endopeptidase inhibitor activity;GO:0017147 Wnt-protein binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:1990909 Wnt signalosome;GO:0098552 side of membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0030336 negative regulation of cell migration;GO:0035115 embryonic forelimb morphogenesis;GO:1903053 regulation of extracellular matrix organization;GO:0001955 blood vessel maturation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z0J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SWT3-1", "uniprot_id": "S2535_MOUSE", "mass": 32631.0, "length": 300, "protein_name": "Solute carrier family 25 member 35", "gene_name": "Slc25a35", "organism": "Mouse", "refseq_name": "solute carrier family 25 member 35 isoform 1", "refseq_ac": "NP_082324", "gene_names_uniprotkb": "Slc25a35", "gene_names_refseq": "1810012H11Rik; Slc25a35", "protein_names_uniprotkb": "Solute carrier family 25 member 35", "protein_names_refseq": "solute carrier family 25 member 35 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71998)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Putative antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBP2;Q99KM5;Q9D913", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5SWT3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YUG0-1", "uniprot_id": "SAM13_MOUSE", "mass": 11336.0, "length": 102, "protein_name": "Sterile alpha motif domain-containing protein 13", "gene_name": "Samd13", "organism": "Mouse", "refseq_name": "sterile alpha motif domain-containing protein 13 isoform 1", "refseq_ac": "NP_001355654", "gene_names_uniprotkb": "Samd13; Gm1652", "gene_names_refseq": "1700013A07Rik; 1700095G21Rik; 4930483N21Rik; Gm1652; Samd13", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 13; SAM domain-containing protein 13", "protein_names_refseq": "DnaJ domain-containing protein; SAM domain-containing protein 13; Sterile alpha motif domain-containing protein 13; sterile alpha motif domain-containing protein 13 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75015)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YUG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3Q0-1", "uniprot_id": "SARAF_MOUSE", "mass": 35856.0, "length": 334, "protein_name": "Store-operated calcium entry-associated regulatory factor", "gene_name": "Saraf", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Saraf; Tmem66", "gene_names_refseq": "", "protein_names_uniprotkb": "Store-operated calcium entry-associated regulatory factor; SARAF; SOCE-associated regulatory factor; Transmembrane protein 66", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:67887)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;22872234;25605945;30779550;31219806;34428180;36210013", "class_list": "", "function": "Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2F1;Q8C6G7;Q8N9S4;Q8R233;Q9D8R1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0006816 calcium ion transport;GO:2001256 regulation of store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R3Q0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V1H9-1", "uniprot_id": "SAMD5_MOUSE", "mass": 19221.0, "length": 173, "protein_name": "Sterile alpha motif domain-containing protein 5", "gene_name": "Samd5", "organism": "Mouse", "refseq_name": "sterile alpha motif domain-containing protein 5", "refseq_ac": "NP_796245", "gene_names_uniprotkb": "Samd5", "gene_names_refseq": "E130306M17Rik; Samd5", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 5; SAM domain-containing protein 5", "protein_names_refseq": "SAM domain-containing protein 5; sterile alpha motif domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:320825)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;28388653;29749928", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H5X3;Q8BJC5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3V1H9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EP69-1", "uniprot_id": "SAC1_MOUSE", "mass": 66944.0, "length": 587, "protein_name": "Phosphatidylinositol-3-phosphatase SAC1", "gene_name": "Sacm1l", "organism": "Mouse", "refseq_name": "phosphatidylinositol-3-phosphatase SAC1 isoform 1", "refseq_ac": "NP_109617", "gene_names_uniprotkb": "Sacm1l; Kiaa0851; Sac1", "gene_names_refseq": "SAC1; Sac1p; Sacm1l; mKIAA0851", "protein_names_uniprotkb": "Phosphatidylinositol-3-phosphatase SAC1; 3.1.3.64; Phosphatidylinositol-4-phosphate phosphatase; Suppressor of actin mutations 1-like protein", "protein_names_refseq": "phosphatidylinositide phosphatase SAC1; phosphatidylinositol-3-phosphatase SAC1 isoform 1; phosphatidylinositol-3-phosphatase SAC1; phosphatidylinositol-4-phosphate phosphatase; polyphosphatidylinositol phosphatase; suppressor of actin mutations 1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:83493); (R-MMU-1483248); (R-MMU-1660514)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11352561;18299350;18480408;21750661;25605945;31155588;32931550;34428180;37068596;37507081;37828378", "class_list": "", "function": "Glycosylation of SR-A was largely attenuated by Sac1 knockdown, but neither mRNA expression nor protein degradation of SR-A were affected. These results suggest that Sac1 maintains SR-A protein levels by modulating SR-A glycosylation., [RefSeq, PubMed]; Lipid phosphatase SAC1 suppresses hepatitis B virus replication through promoting autophagic degradation of virions., [RefSeq, PubMed]; Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:32931550). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (By similarity). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Sac1 executes an essential household function in mammals that involves organization of both Golgi membranes and mitotic spindles, [RefSeq, PubMed]; Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking., [RefSeq, PubMed]; These results suggest direct roles for p38 MAPK and SAC1 in transmitting growth signals to the secretory machinery., [RefSeq, PubMed]; This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Dec 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80TQ1;Q99K33", "ec_number_list": "3.1.3.-;3.1.3.95;3.1.3.36;3.1.3.64", "go_molecular_function": "GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0098969 neurotransmitter receptor transport to postsynaptic membrane;GO:0046856 phosphatidylinositol dephosphorylation;GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane;GO:0099003 vesicle-mediated transport in synapse", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9EP69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A3V2-1", "uniprot_id": "S2543_MOUSE", "mass": 38064.0, "length": 341, "protein_name": "Solute carrier family 25 member 43", "gene_name": "Slc25a43", "organism": "Mouse", "refseq_name": "solute carrier family 25 member 43", "refseq_ac": "NP_001078966", "gene_names_uniprotkb": "Slc25a43; Gm8", "gene_names_refseq": "Gm8; Slc25a43", "protein_names_uniprotkb": "Solute carrier family 25 member 43", "protein_names_refseq": "mitochondrial solute carrier protein; solute carrier family 25 member 43", "tax_id": 10090, "disease": "", "pathway": " (mmu:194744)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RWC0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2A3V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2ADF7-1", "uniprot_id": "S2534_MOUSE", "mass": 33778.0, "length": 318, "protein_name": "Solute carrier family 25 member 34", "gene_name": "Slc25a34", "organism": "Mouse", "refseq_name": "solute carrier family 25 member 34", "refseq_ac": "NP_001013802", "gene_names_uniprotkb": "Slc25a34; Gm1369", "gene_names_refseq": "Gm1369; Slc25a34", "protein_names_uniprotkb": "Solute carrier family 25 member 34", "protein_names_refseq": "solute carrier family 25 member 34", "tax_id": 10090, "disease": "", "pathway": " (mmu:384071)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5FW51", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2ADF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6H687-1", "uniprot_id": "SAC31_MOUSE", "mass": 46384.0, "length": 427, "protein_name": "SAC3 domain-containing protein 1", "gene_name": "Sac3d1", "organism": "Mouse", "refseq_name": "SAC3 domain-containing protein 1", "refseq_ac": "NP_598439", "gene_names_uniprotkb": "Sac3d1; Shd1", "gene_names_refseq": "2410004C24Rik; Sac3d1; shd1", "protein_names_uniprotkb": "SAC3 domain-containing protein 1; SAC3 homology domain-containing protein 1", "protein_names_refseq": "SAC3 domain-containing protein 1; SAC3 homology domain-containing protein 1; Sac3 homology domain 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66406)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15322101;18838617;21750661", "class_list": "", "function": "Involved in centrosome duplication and mitotic progression., [UniProtKB, PubMed]; SHD1 is a novel cytokine-inducible negative feedback regulator of STAT5a., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZMU9;Q8BVY1;Q9QXE1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005819 spindle;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0051301 cell division;GO:0050776 regulation of immune response;GO:0051298 centrosome duplication;GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A6H687-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61609-1", "uniprot_id": "S20A1_MOUSE", "mass": 74153.0, "length": 681, "protein_name": "Sodium-dependent phosphate transporter 1", "gene_name": "Slc20a1", "organism": "Mouse", "refseq_name": "sodium-dependent phosphate transporter 1 isoform 2", "refseq_ac": "NP_001153065", "gene_names_uniprotkb": "Slc20a1; Glvr1; Pit1", "gene_names_refseq": "Glvr-1; Glvr1; Slc20a1", "protein_names_uniprotkb": "Sodium-dependent phosphate transporter 1; GLVR-1; Gibbon ape leukemia virus receptor 1; Leukemia virus receptor 1 homolog; Phosphate transporter 1; PiT-1; Solute carrier family 20 member 1", "protein_names_refseq": "gibbon ape leukemia virus receptor 1; leukemia virus receptor 1 homolog; piT-1; sodium-dependent phosphate transporter 1 isoform 2; sodium-dependent phosphate transporter 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20515); (R-MMU-427652)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10689185;12097582;1309898;1531369;19144319;21750661;25428506;31219806;34428180;35820727;39287391;8046392;8411375;9755124;9916777", "class_list": "", "function": "(Microbial infection) May function as a retroviral receptor but do not confer infection susceptibility to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B)., [UniProtKB, PubMed, PubMed]; Sodium-dependent phosphate transporter PiT1/SLC20A1 as the receptor for the endogenous retroviral envelope syncytin-B involved in mouse placenta formation., [RefSeq, PubMed]; Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Essential for cell proliferation but this function is independent of its phosphate transporter activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AKR9;Q3U244;Q8CBJ1;Q91YQ9;Q9QVW6", "ec_number_list": "", "go_molecular_function": "GO:0005316 high-affinity phosphate:sodium symporter activity;GO:0005315 phosphate transmembrane transporter activity;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0008283 cell population proliferation;GO:0031214 biomineral tissue development;GO:0006814 sodium ion transport;GO:0006817 phosphate ion transport;GO:0035435 phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q61609-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DC26-1", "uniprot_id": "S46A3_MOUSE", "mass": 51383.0, "length": 460, "protein_name": "Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3", "gene_name": "Slc46a3", "organism": "Mouse", "refseq_name": "lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 precursor", "refseq_ac": "NP_082148", "gene_names_uniprotkb": "Slc46a3", "gene_names_refseq": "1200006F02Rik; Slc46a3", "protein_names_uniprotkb": "Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3; Solute carrier family 46 member 3", "protein_names_refseq": "lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 precursor; lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3", "tax_id": 10090, "disease": "", "pathway": " (mmu:71706)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;25605945;28539433;33436590;34235268;34428180;37116499", "class_list": "", "function": "Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm (By similarity). Modulates hepatic cytosolic copper homeostasis, maybe acting as a lysosomal copper transporter and sequestering copper ions in the lysosome (PubMed:33436590). Delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Selectively transports bacterial muramyl dipeptide (MDP) into the cytosol for recognition by NOD2, triggering inflammatory responses (PubMed:28539433, PubMed:37116499). Likely acts as a redundant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages (PubMed:34235268). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015293 symporter activity;GO:0005375 copper ion transmembrane transporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine;GO:0034486 vacuolar transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DC26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XD8-1", "uniprot_id": "S2538_MOUSE", "mass": 35390.0, "length": 326, "protein_name": "Mitochondrial glycine transporter", "gene_name": "Slc25a38", "organism": "Mouse", "refseq_name": "mitochondrial glycine transporter isoform 1", "refseq_ac": "NP_659042", "gene_names_uniprotkb": "Slc25a38", "gene_names_refseq": "Slc25a38; appoptosin", "protein_names_uniprotkb": "Mitochondrial glycine transporter; Appoptosin; Solute carrier family 25 member 38", "protein_names_refseq": "mitochondrial glycine transporter isoform 1; mitochondrial glycine transporter", "tax_id": 10090, "disease": "autosomal recessive pyridoxine-refractory sideroblastic anemia 2 (Disease Ontology:DOID:0060065); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (mmu:208638)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23115192;29568862;31219806", "class_list": "", "function": "Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis., [UniProtKB, HAMAP]; Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis., [UniProtKB, PubMed]; Silencing of appoptosin using short hairpin RNA significantly reduced CoCl2induced apoptosis in MIN6 cells. In conclusion, CoCl2 increased the expression of appoptosin, which aggravated mitochondrial damage in MIN6 cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0030218 erythrocyte differentiation;GO:1904983 glycine import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91XD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MR3-1", "uniprot_id": "S12A9_MOUSE", "mass": 96330.0, "length": 914, "protein_name": "Solute carrier family 12 member 9", "gene_name": "Slc12a9", "organism": "Mouse", "refseq_name": "solute carrier family 12 member 9", "refseq_ac": "NP_113583", "gene_names_uniprotkb": "Slc12a9; Cip1; Slc12a8", "gene_names_refseq": "CIP1; Slc12a9", "protein_names_uniprotkb": "Solute carrier family 12 member 9; Cation-chloride cotransporter-interacting protein 1; Potassium-chloride transporter 9", "protein_names_refseq": "cation-chloride cotransporter-interacting protein 1; potassium-chloride transporter 9; solute carrier family 12 member 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:83704)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11239002;19349973;21750661;25428506;29187734;30899004;31219806;31599954", "class_list": "", "function": "May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function. May play a role in lysosomal ion flux and osmoregulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QNN4", "ec_number_list": "", "go_molecular_function": "GO:0015379 potassium:chloride symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis;GO:0055064 chloride ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q99MR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N85-1", "uniprot_id": "RT18A_MOUSE", "mass": 22321.0, "length": 196, "protein_name": "Large ribosomal subunit protein mL66", "gene_name": "Mrps18a", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL66 precursor", "refseq_ac": "NP_081044", "gene_names_uniprotkb": "Mrps18a", "gene_names_refseq": "1110004O20Rik; Mrps18a", "protein_names_uniprotkb": "Large ribosomal subunit protein mL66; 28S ribosomal protein S18-3, mitochondrial; 28S ribosomal protein S18a, mitochondrial; MRP-S18-3; MRP-S18-a; Mrps18a; S18mt-a", "protein_names_refseq": "28S ribosomal protein S18-3, mitochondrial; 28S ribosomal protein S18a, mitochondrial; MRP-S18-3; MRP-S18-a; S18mt-a; large ribosomal subunit protein mL66 precursor; large ribosomal subunit protein mL66", "tax_id": 10090, "disease": "", "pathway": " (mmu:68565); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11402041;21750661;26495903;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3H2;Q9D1J6", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99N85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0VE29-1", "uniprot_id": "SAM12_MOUSE", "mass": 18245.0, "length": 161, "protein_name": "Sterile alpha motif domain-containing protein 12", "gene_name": "Samd12", "organism": "Mouse", "refseq_name": "sterile alpha motif domain-containing protein 12", "refseq_ac": "NP_796199", "gene_names_uniprotkb": "Samd12", "gene_names_refseq": "A830094I09Rik; Samd12", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 12; SAM domain-containing protein 12", "protein_names_refseq": "SAM domain-containing protein 12; sterile alpha motif domain-containing protein 12", "tax_id": 10090, "disease": "familial adult myoclonic epilepsy 1 (Disease Ontology:DOID:0111690)", "pathway": " (mmu:320679)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VE29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2Q8-1", "uniprot_id": "S10AE_MOUSE", "mass": 11599.0, "length": 104, "protein_name": "Protein S100-A14", "gene_name": "S100a14", "organism": "Mouse", "refseq_name": "protein S100-A14 isoform a", "refseq_ac": "NP_001156997", "gene_names_uniprotkb": "S100a14; Gm1020; S100a15", "gene_names_refseq": "1110013O05Rik; S100a14; S100a15; S114", "protein_names_uniprotkb": "Protein S100-A14; S100 calcium-binding protein A14; S114", "protein_names_refseq": "S100 calcium binding protein A15; protein S100-A14 isoform a; protein S100-A14", "tax_id": 10090, "disease": "", "pathway": " (mmu:66166)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;31263990;33579599;34428180;39627609", "class_list": "", "function": "Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium (By similarity)., [UniProtKB]; S100A14 enhanced scattering, motility and invasiveness of mouse tumor cells., [RefSeq, PubMed]; S100A14 promotes progression and gemcitabine resistance in pancreatic cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1D8", "ec_number_list": "", "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0042379 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0090026 positive regulation of monocyte chemotaxis;GO:0006915 apoptotic process;GO:0042742 defense response to bacterium;GO:0034142 toll-like receptor 4 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D2Q8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWX4-1", "uniprot_id": "RUSD4_MOUSE", "mass": 42407.0, "length": 377, "protein_name": "Pseudouridylate synthase RPUSD4, mitochondrial", "gene_name": "Rpusd4", "organism": "Mouse", "refseq_name": "pseudouridylate synthase RPUSD4, mitochondrial", "refseq_ac": "NP_082316", "gene_names_uniprotkb": "Rpusd4", "gene_names_refseq": "2410001E19Rik; Rpusd4", "protein_names_uniprotkb": "Pseudouridylate synthase RPUSD4, mitochondrial; 5.4.99.-; RNA pseudouridylate synthase domain-containing protein 4", "protein_names_refseq": "RNA pseudouridylate synthase domain-containing protein 4; mitochondrial RNA pseudouridine synthase Rpusd4; pseudouridylate synthase RPUSD4, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:71989)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;29187734;31219806;35820727", "class_list": "", "function": "Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Acts on position 39 in mitochondrial tRNA(Phe). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.4.99.-;5.4.99.42;5.4.99.28;5.4.99.25;5.4.99.12", "go_molecular_function": "GO:0000049 tRNA binding;GO:0009982 pseudouridine synthase activity;GO:0106029 tRNA pseudouridine synthase activity;GO:1990400 mitochondrial ribosomal large subunit rRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0031118 rRNA pseudouridine synthesis;GO:1990481 mRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CWX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5N8-1", "uniprot_id": "SATL1_MOUSE", "mass": 83276.0, "length": 744, "protein_name": "Spermidine/spermine N(1)-acetyltransferase-like protein 1", "gene_name": "Satl1", "organism": "Mouse", "refseq_name": "spermidine/spermine N(1)-acetyltransferase-like protein 1", "refseq_ac": "NP_082931", "gene_names_uniprotkb": "Satl1", "gene_names_refseq": "4930404K22Rik; Satl1", "protein_names_uniprotkb": "Spermidine/spermine N(1)-acetyltransferase-like protein 1; 2.3.1.-", "protein_names_refseq": "spermidine/spermine N(1)-acetyltransferase-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73809)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EHI8", "ec_number_list": "", "go_molecular_function": "GO:0004145 diamine N-acetyltransferase activity;GO:0019809 spermidine binding;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups", "go_cellular_component": "", "go_biological_process": "GO:0032918 spermidine acetylation;GO:0006595 polyamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D5N8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62273-1", "uniprot_id": "S26A2_MOUSE", "mass": 81604.0, "length": 739, "protein_name": "Sulfate transporter", "gene_name": "Slc26a2", "organism": "Mouse", "refseq_name": "sulfate transporter", "refseq_ac": "NP_031911", "gene_names_uniprotkb": "Slc26a2; Dtdst; Dtd", "gene_names_refseq": "Dtd; ST-OB; Slc26a2", "protein_names_uniprotkb": "Sulfate transporter; Diastrophic dysplasia protein homolog; ST-OB; Solute carrier family 26 member 2", "protein_names_refseq": "diastrophic dysplasia protein homolog; solute carrier family 26 member 2; sulfate transporter", "tax_id": 10090, "disease": "brachydactyly (Disease Ontology:DOID:0050581); atelosteogenesis (Disease Ontology:DOID:0050648); multiple epiphyseal dysplasia 4 (Disease Ontology:DOID:0070300); achondrogenesis type IB (Disease Ontology:DOID:0080055); diastrophic dysplasia (Disease Ontology:DOID:14687); osteochondrodysplasia (Disease Ontology:DOID:2256); spondylolysis (Disease Ontology:DOID:2300); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676)", "pathway": " (mmu:13521); (R-MMU-174362); (R-MMU-427601)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "20219950;21750661;22190686;24302720;25428506;30084848;30685387;31914611;34428180;9370300", "class_list": "glycogene", "function": "Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (PubMed:24302720). Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions (PubMed:20219950, PubMed:22190686, PubMed:24302720). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (PubMed:22190686). Essential for chondrocyte proliferation, differentiation and cell size expansion (PubMed:24302720)., [UniProtKB, PubMed, PubMed, PubMed]; Support a multifactorial etiology, involving congenitally predisposed isthmic conditions, altered biomechanics, and age-dependent bone loss, which leads to SLC26A2-related spondylolysis, [RefSeq, PubMed]; The present study has expanded our view of the sulfate transporter SLC26A2 to the unexpected field of collagen secretion and proteostasis. Our findings will facilitate the understanding of genotype-phenotype relationships of SLC26A2-related chondrodysplasias and accelerate the development of drug therapy against ACG1B and AO2., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 42, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q543D6;Q8R2L9", "ec_number_list": "", "go_molecular_function": "GO:0005452 solute:inorganic anion antiporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031528 microvillus membrane;GO:0016020 membrane", "go_biological_process": "GO:0019532 oxalate transport;GO:1902476 chloride transmembrane transport;GO:0002062 chondrocyte differentiation;GO:0035988 chondrocyte proliferation;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62273-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CY86-1", "uniprot_id": "SAPC1_MOUSE", "mass": 16181.0, "length": 146, "protein_name": "Suppressor APC domain-containing protein 1", "gene_name": "Sapcd1", "organism": "Mouse", "refseq_name": "suppressor APC domain-containing protein 1", "refseq_ac": "NP_076382", "gene_names_uniprotkb": "Sapcd1; G7d; Ng23", "gene_names_refseq": "2810436B06Rik; G7d; Ng23; Sapcd1", "protein_names_uniprotkb": "Suppressor APC domain-containing protein 1; Protein G7d", "protein_names_refseq": "protein G7d; suppressor APC domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:78376)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11797099;14656967;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RWH1;Q9Z1Q7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CY86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C5K0-1", "uniprot_id": "SBK3_MOUSE", "mass": 39117.0, "length": 361, "protein_name": "Uncharacterized serine/threonine-protein kinase SBK3", "gene_name": "Sbk3", "organism": "Mouse", "refseq_name": "uncharacterized serine/threonine-protein kinase SBK3", "refseq_ac": "NP_001186970", "gene_names_uniprotkb": "Sbk3; Gm1078; Sgk110", "gene_names_refseq": "Gm1078; Sbk3; Sgk110", "protein_names_uniprotkb": "Uncharacterized serine/threonine-protein kinase SBK3; 2.7.11.1; SH3 domain-binding kinase family member 3; Sugen kinase 110", "protein_names_refseq": "SH3-binding domain kinase family member 3; sugen kinase 110; uncharacterized serine/threonine-protein kinase SBK3", "tax_id": 10090, "disease": "", "pathway": " (mmu:381835)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15289607", "class_list": "", "function": "First described as a protein kinase and named SgK110 (Sugen Kinase 110) after its human ortholog., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3Z5J0;E9QLM1", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C5K0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12246-1", "uniprot_id": "SAMP_MOUSE", "mass": 26247.0, "length": 224, "protein_name": "Serum amyloid P-component", "gene_name": "Apcs", "organism": "Mouse", "refseq_name": "serum amyloid P-component precursor", "refseq_ac": "NP_035448", "gene_names_uniprotkb": "Apcs; Ptx2; Sap", "gene_names_refseq": "Apcs; Sap", "protein_names_uniprotkb": "Serum amyloid P-component; SAP", "protein_names_refseq": "APCS amyloid P-component serum protein; serum amyloid P-component precursor; serum amyloid P-component", "tax_id": 10090, "disease": "amyloidosis (Disease Ontology:DOID:9120)", "pathway": " (mmu:20219)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17330941;23386199;2481440;3169883;3183383;3263126;34145258;34428180;36243399;3658681", "class_list": "", "function": "SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis., [RefSeq, PubMed]; Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0001849 complement component C1q complex binding;GO:0046790 virion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0045087 innate immune response;GO:0006953 acute-phase response;GO:0048525 negative regulation of viral process;GO:0045656 negative regulation of monocyte differentiation;GO:0044871 negative regulation by host of viral glycoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P12246-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27005-1", "uniprot_id": "S10A8_MOUSE", "mass": 10295.0, "length": 89, "protein_name": "Protein S100-A8", "gene_name": "S100a8", "organism": "Mouse", "refseq_name": "protein S100-A8", "refseq_ac": "NP_038678", "gene_names_uniprotkb": "S100a8; Caga; Mrp8", "gene_names_refseq": "60B8Ag; B8Ag; CFAg; CP-10; Caga; MRP8; S100a8; p8", "protein_names_uniprotkb": "Protein S100-A8; Calgranulin-A; Chemotactic cytokine CP-10; Leukocyte L1 complex light chain; MRP-8; Migration inhibitory factor-related protein 8; Pro-inflammatory S100 cytokine; S100 calcium-binding protein A8; p8", "protein_names_refseq": "MRP-8; S100 calcium-binding protein A8; calgranulin-A; chemotactic S100 protein; chemotactic cytokine CP-10; leukocyte L1 complex light chain; migration inhibitory factor-related protein 8; pro-inflammatory S100 cytokine; protein S100-A8", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); myocarditis (Disease Ontology:DOID:820)", "pathway": " (mmu:20201); (R-MMU-5668599); (R-MMU-5686938); (R-MMU-6798695); (R-MMU-6799990)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "10438963;1373330;1559987;17767165;18250455;18403730;18832721;19224205;20173027;20213444;20523765;27802388;30084848;30779550;31219806;33388094;34428180;35984892;8454868;8611640", "class_list": "glycogene", "function": "(Microbial infection) Upon infection by murine coronavirus (MHV-A59), induces expansion of aberrant immature neutrophils in a TLR4-dependent manner., [UniProtKB, PubMed]; S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Also participates in regulatory T-cell differentiation together with CD69. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its pro-inflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the pro-inflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. The iNOS-S100A8/A9 transnitrosylase complex is proposed to direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as GAPDH, ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 20, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P31724", "ec_number_list": "", "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "GO:0018119 peptidyl-cysteine S-nitrosylation;GO:0032496 response to lipopolysaccharide;GO:0034121 regulation of toll-like receptor signaling pathway;GO:0045087 innate immune response;GO:0002793 positive regulation of peptide secretion", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P27005-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50114-1", "uniprot_id": "S100B_MOUSE", "mass": 10728.0, "length": 92, "protein_name": "Protein S100-B", "gene_name": "S100b", "organism": "Mouse", "refseq_name": "protein S100-B", "refseq_ac": "NP_033141", "gene_names_uniprotkb": "S100b", "gene_names_refseq": "Bpb; S100b", "protein_names_uniprotkb": "Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B", "protein_names_refseq": "S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B; protein S100-B", "tax_id": 10090, "disease": "sleep apnea (Disease Ontology:DOID:0050847); stroke (Disease Ontology:DOID:0051061); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); migraine without aura (Disease Ontology:DOID:12783); dilated cardiomyopathy (Disease Ontology:DOID:12930); aspergillosis (Disease Ontology:DOID:13564); Machado-Joseph disease (Disease Ontology:DOID:1440); depressive disorder (Disease Ontology:DOID:1596); brain ischemia (Disease Ontology:DOID:2316); West Nile fever (Disease Ontology:DOID:2366); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); demyelinating disease (Disease Ontology:DOID:3213); bipolar disorder (Disease Ontology:DOID:3312); middle cerebral artery infarction (Disease Ontology:DOID:3525); brain edema (Disease Ontology:DOID:4724); borna disease (Disease Ontology:DOID:5154); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); neuromyelitis optica (Disease Ontology:DOID:8869); brain disease (Disease Ontology:DOID:936); bacterial meningitis (Disease Ontology:DOID:9470)", "pathway": " (mmu:20203); (R-MMU-445989); (R-MMU-879415); (R-MMU-933542)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "25884569;2592414;31043739;8202493;8376406", "class_list": "", "function": "Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (By similarity). Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (By similarity). Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (By similarity). Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (PubMed:2592414, PubMed:8202493). Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (PubMed:31043739). Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (By similarity). Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity). May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0097490 sympathetic neuron projection extension;GO:0007155 cell adhesion;GO:0007611 learning or memory;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50114-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58355-1", "uniprot_id": "S45A2_MOUSE", "mass": 57961.0, "length": 530, "protein_name": "Membrane-associated transporter protein", "gene_name": "Slc45a2", "organism": "Mouse", "refseq_name": "membrane-associated transporter protein", "refseq_ac": "NP_444307", "gene_names_uniprotkb": "Slc45a2; Aim1; Matp; uw", "gene_names_refseq": "Aim-1; Aim1; Dbr; Matp; Oca4; Slc45a2; blanc-sale; bls; uw", "protein_names_uniprotkb": "Membrane-associated transporter protein; Melanoma antigen AIM1; Protein AIM-1; Protein underwhite; Solute carrier family 45 member 2", "protein_names_refseq": "B/AIM-1-like protein; dominant brown; melanoma antigen AIM1; membrane-associated transporter protein; protein AIM-1; protein underwhite", "tax_id": 10090, "disease": "oculocutaneous albinism (Disease Ontology:DOID:0050632); oculocutaneous albinism type IV (Disease Ontology:DOID:0070098); pigmentation disease (Disease Ontology:DOID:10123); cataract (Disease Ontology:DOID:83)", "pathway": " (mmu:22293); (R-MMU-5662702)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11479596;11574907;25164149;32966160;35469906;35820727", "class_list": "", "function": "MRNA expression of SLC45A2 in eyes and skin and of SLC45A3 primarily in the prostate, but also in other tissues, whereas SLC45A4 showed a predominantly ubiquitous expression, [RefSeq, PubMed]; Proton-associated glucose and sucrose transporter (PubMed:25164149, PubMed:35469906). May be able to transport also fructose (PubMed:25164149). Expressed at a late melanosome maturation stage where functions as a proton/glucose exporter which increase lumenal pH by decreasing glycolysis (PubMed:32966160, PubMed:35469906). Regulates melanogenesis by maintaining melanosome neutralization that is initially initiated by transient OCA2 and required for a proper function of the tyrosinase TYR (PubMed:32966160, PubMed:35469906)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008506 sucrose:proton symporter activity;GO:0005356 D-glucose:proton symporter activity", "go_cellular_component": "GO:0033162 melanosome membrane", "go_biological_process": "GO:0007601 visual perception;GO:0048066 developmental pigmentation;GO:0035752 lysosomal lumen pH elevation;GO:0015770 sucrose transport;GO:0006583 melanin biosynthetic process from tyrosine", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P58355-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62818-1", "uniprot_id": "S10A3_MOUSE", "mass": 11747.0, "length": 101, "protein_name": "Protein S100-A3", "gene_name": "S100a3", "organism": "Mouse", "refseq_name": "protein S100-A3", "refseq_ac": "NP_035440", "gene_names_uniprotkb": "S100a3", "gene_names_refseq": "S100E; S100a3", "protein_names_uniprotkb": "Protein S100-A3; Protein S-100E; S100 calcium-binding protein A3", "protein_names_refseq": "protein S100-A3", "tax_id": 10090, "disease": "", "pathway": " (mmu:20197)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31219806;9804353;9920416", "class_list": "", "function": "Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P56566", "ec_number_list": "", "go_molecular_function": "GO:0046914 transition metal ion binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62818-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97816-1", "uniprot_id": "S100G_MOUSE", "mass": 8970.0, "length": 79, "protein_name": "Protein S100-G", "gene_name": "S100g", "organism": "Mouse", "refseq_name": "protein S100-G", "refseq_ac": "NP_033919", "gene_names_uniprotkb": "S100g; Calb3; S100d", "gene_names_refseq": "CABP1; CaBP-D9K; Cabp9k; Calb3; S100g", "protein_names_uniprotkb": "Protein S100-G; CABP; Calbindin-D9k; S100 calcium-binding protein G; Vitamin D-dependent calcium-binding protein, intestinal", "protein_names_refseq": "CABP; calbindin 3, (vitamin D-dependent calcium binding protein); calbindin D9k; calbindin-D9K major form; cytidine 5'-triphosphate synthase 2; protein S100-G; vitamin D-dependent calcium-binding protein, intestinal", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714)", "pathway": " (mmu:12309)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "32114281;32357291", "class_list": "", "function": "Calbindin-D9k is a Novel Risk Gene for Neurodegenerative Disease., [RefSeq, PubMed]; Mouse S100G protein exhibits properties characteristic of a calcium sensor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046914 transition metal ion binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0005499 vitamin D binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97816-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1LZI2-1", "uniprot_id": "S35F3_MOUSE", "mass": 46924.0, "length": 421, "protein_name": "Solute carrier family 35 member F3", "gene_name": "Slc35f3", "organism": "Mouse", "refseq_name": "solute carrier family 35 member F3 isoform 2", "refseq_ac": "NP_780643", "gene_names_uniprotkb": "Slc35f3", "gene_names_refseq": "B230375D17Rik; Slc35f3", "protein_names_uniprotkb": "Solute carrier family 35 member F3; Thiamine transporter SLC35F3", "protein_names_refseq": "putative thiamine transporter SLC35F3; solute carrier family 35 member F3 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:210027)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Mediates thiamine transport. Also mediates choline transport, although the underlying transport mechanism remains to be elucidated (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BL51", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015220 choline transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015871 choline transport;GO:0015888 thiamine transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1LZI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TZ89-1", "uniprot_id": "SC31B_MOUSE", "mass": 125633.0, "length": 1158, "protein_name": "Protein transport protein Sec31B", "gene_name": "Sec31b", "organism": "Mouse", "refseq_name": "protein transport protein Sec31B", "refseq_ac": "NP_001028515", "gene_names_uniprotkb": "Sec31b; Gm341; Sec31l2", "gene_names_refseq": "Gm341; Sec31b; Sec31l2", "protein_names_uniprotkb": "Protein transport protein Sec31B; SEC31-like protein 2; SEC31-related protein B", "protein_names_refseq": "SEC31-like 2; SEC31-like protein 2; SEC31-related protein B; Sec31 homolog B; protein transport protein Sec31B", "tax_id": 10090, "disease": "Halperin-Birk syndrome (Disease Ontology:DOID:0070539)", "pathway": " (mmu:240667); (R-MMU-204005)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;25428506;31599954;34203471;37507081", "class_list": "", "function": "As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q811L4", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0030120 vesicle coat;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0015031 protein transport;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3TZ89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V050-1", "uniprot_id": "S47A2_MOUSE", "mass": 61789.0, "length": 573, "protein_name": "Multidrug and toxin extrusion protein 2", "gene_name": "Slc47a2", "organism": "Mouse", "refseq_name": "multidrug and toxin extrusion protein 2", "refseq_ac": "NP_001028714", "gene_names_uniprotkb": "Slc47a2; Mate2", "gene_names_refseq": "4933429E10Rik; Slc47a2", "protein_names_uniprotkb": "Multidrug and toxin extrusion protein 2; H(+)/organic cation antiporter kidney-specific; MATE-2; Solute carrier family 47 member 2; mMATE-2", "protein_names_refseq": "MATE-2; h(+)/organic cation antiporter kidney-specific; mMATE-2; multidrug and toxin extrusion protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:380701)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17715386;18573474;20016398;21750661", "class_list": "", "function": "MATE2 mRNA expression levels were the highest in the testis, where high expression was localized to Sertoli cells, a critical cell type of the blood testis barrier., [RefSeq, PubMed]; Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:17715386). May mediate testosterone efflux from the Leydig cells in the testes (PubMed:17715386)., [UniProtKB, PubMed]; Testes-specific multidrug and toxic compound extrusion 2 (MATE2) act as a polyspecific H(+)/organic cation exporter in Leydig cells., [RefSeq, PubMed]; The purpose of this study was to evaluate the effects of heterozygous MATE variants on the disposition of metformin in mice and humans., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RXN1;Q5SS46", "ec_number_list": "", "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015234 thiamine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0015695 organic cation transport;GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3V050-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q49B93-1", "uniprot_id": "SC5AC_MOUSE", "mass": 67951.0, "length": 619, "protein_name": "Sodium-coupled monocarboxylate transporter 2", "gene_name": "Slc5a12", "organism": "Mouse", "refseq_name": "sodium-coupled monocarboxylate transporter 2 isoform 1", "refseq_ac": "NP_001003915", "gene_names_uniprotkb": "Slc5a12; Smct2", "gene_names_refseq": "D630015G19; SMCT2; Slc5a12", "protein_names_uniprotkb": "Sodium-coupled monocarboxylate transporter 2; Electroneutral sodium monocarboxylate cotransporter; Low-affinity sodium-lactate cotransporter; Solute carrier family 5 member 12", "protein_names_refseq": "electroneutral sodium monocarboxylate cotransporter; low-affinity sodium-lactate cotransporter; sodium solute cotransporter; sodium-coupled monocarboxylate transporter 2 isoform 1; sodium-coupled monocarboxylate transporter 2; solute carrier family 5 member 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:241612); (R-MMU-428643)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "16104846;16873376;17591909;17692818;20834181;22123132;30084848;31708446;35820727", "class_list": "", "function": "A low affinity type of SMCT2-like transporter is in operation with high capacity throughout the small intestine, playing the role as the major intestinal nicotinate uptake transporter., [RefSeq, PubMed]; Acts as an electroneutral and low-affinity sodium Na(+)-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Probably part of D-serine transport systems involved in D-serine reabsorption at the brush border of renal proximal tubules., [UniProtKB, PubMed, PubMed, UniProtKB]; Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring., [RefSeq, PubMed]; Low-affinity transporter SMCT2 initiates lactate absorption in the early parts of the proximal tubule followed by the participation of the high-affinity transporter SMCT1 in the latter parts of the proximal tubule., [RefSeq, PubMed]; SMCT2 was localized in the brush border of enterocytes in the intestinal villi, and SMCT2 was localized in the brush border of is a jejunal type of SCMT., [RefSeq, PubMed]; Slc5a8 and slc5a12 in kidney in c/ebpdelta-/- mice have a role in the renal handling of lactate and urate, [RefSeq, PubMed]; The cloning and characterization of slc5a12 (SMCT2) is reported., [RefSeq, PubMed]; These data provide the first evidence for the expression of SMCT1 and SMCT2 in the retina and for the cell-type specific distribution of these transporters within the retina., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0D2G1;Q6A4K8", "ec_number_list": "", "go_molecular_function": "GO:0015293 symporter activity;GO:0015129 lactate transmembrane transporter activity;GO:0140161 monocarboxylate:sodium symporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q49B93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DTT4-1", "uniprot_id": "RTL5_MOUSE", "mass": 68721.0, "length": 599, "protein_name": "Retrotransposon Gag-like protein 5", "gene_name": "Rtl5", "organism": "Mouse", "refseq_name": "retrotransposon Gag-like protein 5", "refseq_ac": "NP_001265463", "gene_names_uniprotkb": "Rtl5; Kiaa2001; Rgag4", "gene_names_refseq": "6430402L03Rik; Mar5; Mart5; Rgag4; Rtl5; mKIAA2001", "protein_names_uniprotkb": "Retrotransposon Gag-like protein 5; Retrotransposon gag domain-containing protein 4", "protein_names_refseq": "gag-like protein; retrotransposon Gag-like protein 5; retrotransposon gag domain containing 4; retrotransposon gag domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:331474)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16093683;28919299;34428180", "class_list": "", "function": "The results introduce Rgag4 to the repertoire of effectors serving to couple the chromatin remodeler Ikaros with the hormonal stress response., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5DTT4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F297-1", "uniprot_id": "S35G3_MOUSE", "mass": 35573.0, "length": 340, "protein_name": "Solute carrier family 35 member G3", "gene_name": "Slc35g3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Slc35g3; Amac1", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 35 member G3; Acyl-malonyl-condensing enzyme 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "35820727;41222000;9056918", "class_list": "", "function": "Testis-specific UDP-N-acetylglucosamine transporter that mediates transport of nucleotide sugars to facilitate the proper glycosylation of proteins critical for sperm function., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35281", "ec_number_list": "", "go_molecular_function": "GO:0015220 choline transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5F297-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60648-1", "uniprot_id": "SAP3_MOUSE", "mass": 20824.0, "length": 193, "protein_name": "Ganglioside GM2 activator", "gene_name": "Gm2a", "organism": "Mouse", "refseq_name": "ganglioside GM2 activator precursor", "refseq_ac": "NP_034429", "gene_names_uniprotkb": "Gm2a", "gene_names_refseq": "GM2-AP; Gm2a; SAP-3", "protein_names_uniprotkb": "Ganglioside GM2 activator; Cerebroside sulfate activator protein; GM2-AP; SAP-3; Sphingolipid activator protein 3", "protein_names_refseq": "cerebroside sulfate activator protein; ganglioside GM2 activator precursor; ganglioside GM2 activator; shingolipid activator protein 3; sphingolipid activator protein 3", "tax_id": 10090, "disease": "GM2 gangliosidosis (Disease Ontology:DOID:3321); GM2 gangliosidosis, AB variant (Disease Ontology:DOID:4795)", "pathway": " (mmu:14667); (R-MMU-6798695); (R-MMU-9840310)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "16216074;23386199;26495903;26740625;29100724;32152506;7689829;7713516;9060405", "class_list": "glycogene", "function": "Lipid-binding and transfer protein essential for lysosomal degradation of ganglioside GM2. Extracts single GM2 molecules from intralysosomal luminal vesicle (ILV) membranes and presents them in soluble form to beta-hexosaminidase A (HEXA) for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Forms a stoichiometric GM2-GM2A complex that serves as the substrate for HEXA (By similarity). Also stimulates the breakdown of glycolipid GA2 by HEXA (PubMed:16216074). Possesses dual function: membrane lipid mobilization/solubilization and lipid substrate presentation to hydrolases (By similarity). The large binding pocket can accommodate several single-chain phospholipids and fatty acids. Exhibits some calcium-independent phospholipase activity (PubMed:16216074). Participates in cholesterol transfer (By similarity)., [UniProtKB, PubMed, UniProtKB]; The most interesting finding was the association of the GM2-AP with the acrosomal apparatus in early spermatids. A modest to intense staining was observed in some acrosomal granules and acrosomal caps. The GM2-AP seemed to disappear from acrosomal caps in the later stage of spermatids, in which the nucleus became elongated and condensed., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q61610;Q61819", "ec_number_list": "", "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0008047 enzyme activator activity;GO:0016004 phospholipase activator activity;GO:0004563 beta-N-acetylhexosaminidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016323 basolateral plasma membrane;GO:0005764 lysosome;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0006869 lipid transport;GO:0007611 learning or memory;GO:0050885 neuromuscular process controlling balance;GO:0050877 nervous system process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q60648-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62255-1", "uniprot_id": "SALL3_MOUSE", "mass": 138760.0, "length": 1320, "protein_name": "Sal-like protein 3", "gene_name": "Sall3", "organism": "Mouse", "refseq_name": "sal-like protein 3 isoform 2", "refseq_ac": "NP_840064", "gene_names_uniprotkb": "Sall3; Sal", "gene_names_refseq": "B130022O04Rik; Msal-1; Msal; Sall3; Salt; Sal; Spalt", "protein_names_uniprotkb": "Sal-like protein 3; MSal; Spalt-like protein 3", "protein_names_refseq": "sal-like 3; sal-like protein 3 isoform 2; sal-like protein 3; spalt-like protein 3", "tax_id": 10090, "disease": "carcinoma (Disease Ontology:DOID:305)", "pathway": " (mmu:20689)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16545361;21750661;30084848;34678516;8798152", "class_list": "", "function": "Probable transcription factor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q08EB0;Q52KR5;Q6GQT8;Q8BRD9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007224 smoothened signaling pathway;GO:0035136 forelimb morphogenesis;GO:0035137 hindlimb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62255-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P8J2-1", "uniprot_id": "SAT2_MOUSE", "mass": 19305.0, "length": 170, "protein_name": "Thialysine N-epsilon-acetyltransferase", "gene_name": "Sat2", "organism": "Mouse", "refseq_name": "thialysine N-epsilon-acetyltransferase isoform 1", "refseq_ac": "NP_081267", "gene_names_uniprotkb": "Sat2; Ssat2", "gene_names_refseq": "2610016A03Rik; SSAT-2; SSAT2; Sat2", "protein_names_uniprotkb": "Thialysine N-epsilon-acetyltransferase; 2.3.1.-; 2.3.1.57; Diamine acetyltransferase 2; SSAT-2; Spermidine/spermine N(1)-acetyltransferase 2", "protein_names_refseq": "diamine acetyltransferase 2; polyamine N-acetyltransferase 2; spermidine/spermine N(1)-acetyltransferase 2; thialysine N-epsilon-acetyltransferase isoform 1; thialysine N-epsilon-acetyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:69215)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17371273;19164485;23806337;28578006;31253191;35819096", "class_list": "", "function": "Catalyzes the N-acetylation of the amino acid thialysine (S-(2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur. May also catalyze acetylation of polyamines, such as norspermidine, spermidine or spermine. However, ability to acetylate polyamines is weak, suggesting that it does not act as a diamine acetyltransferase in vivo., [UniProtKB, UniProtKB]; In testis tissue subjected to busulfan, increased expression of Sat2 can cause cellular injury and subsequent organ damage, which could lead to male infertility. Therefore, Sat2 may be a novel molecular target for treating busulfan-induced testicular toxicity., [RefSeq, PubMed]; SAT2 regulates Sertoli cell-germline interactions via STIM1-mediated ROS/WNT/beta-catenin signaling pathway., [RefSeq, PubMed]; Sat2 acts as a tumor promoter in the adenomaatous polyposis coli mouse (Min/+) model., [RefSeq, PubMed]; Spermidine/spermine-N(1)-acetyltransferase ablation impacts tauopathy-induced polyamine stress response. Publication Status: Online-Only, [RefSeq, PubMed]; These studies indicate that SAT2 deficient animals are protected against ischemia-reperfusion injuries (IRI) and suggest that SAT2 is an important mediator of the tissue damage in IRI., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5F299", "ec_number_list": "2.3.1.57;2.3.1.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004145 diamine N-acetyltransferase activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0008216 spermidine metabolic process;GO:0032918 spermidine acetylation;GO:0032919 spermine acetylation;GO:0032920 putrescine acetylation;GO:0046204 nor-spermidine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6P8J2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PGC7-1", "uniprot_id": "S35E3_MOUSE", "mass": 34892.0, "length": 313, "protein_name": "Solute carrier family 35 member E3", "gene_name": "Slc35e3", "organism": "Mouse", "refseq_name": "solute carrier family 35 member E3", "refseq_ac": "NP_084151", "gene_names_uniprotkb": "Slc35e3", "gene_names_refseq": "9330166G04Rik; Slc35e3", "protein_names_uniprotkb": "Solute carrier family 35 member E3", "protein_names_refseq": "solute carrier family 35 member E3", "tax_id": 10090, "disease": "", "pathway": " (mmu:215436)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20173027", "class_list": "", "function": "Putative transporter., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0005338 nucleotide-sugar transmembrane transporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PGC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6R6I7-1", "uniprot_id": "RXFP1_MOUSE", "mass": 86957.0, "length": 758, "protein_name": "Relaxin receptor 1", "gene_name": "Rxfp1", "organism": "Mouse", "refseq_name": "relaxin receptor 1 precursor", "refseq_ac": "NP_997617", "gene_names_uniprotkb": "Rxfp1; Gm1018; Lgr7", "gene_names_refseq": "Gm1018; Lgr7; Rxfp1", "protein_names_uniprotkb": "Relaxin receptor 1; Leucine-rich repeat-containing G protein-coupled receptor 7; Relaxin family peptide receptor 1", "protein_names_refseq": "leucine-rich repeat-containing 7; leucine-rich repeat-containing G-protein coupled receptor 7; relaxin family peptide receptor 1; relaxin receptor 1 precursor; relaxin receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:381489); (R-MMU-418555); (R-MMU-444821)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12679517;15566402;15956710;21750661;25428506", "class_list": "", "function": "Expression of lgr7 in mouse brain membranes and neurons, [RefSeq, PubMed]; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q80UD3", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0046872 metal ion binding;GO:0042562 hormone binding;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0030154 cell differentiation;GO:0030198 extracellular matrix organization;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0009755 hormone-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6R6I7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76M72-1", "uniprot_id": "S22AR_MOUSE", "mass": 62045.0, "length": 551, "protein_name": "Solute carrier family 22 member 27", "gene_name": "Slc22a27", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 27 isoform 1", "refseq_ac": "NP_599017", "gene_names_uniprotkb": "Slc22a27; Oat9", "gene_names_refseq": "OAT6-L; OAT6-S; Oat9; Slc22a27", "protein_names_uniprotkb": "Solute carrier family 22 member 27; Organic anion transporter 9", "protein_names_refseq": "mOAT6 related protein; organic anion transporter 6; organic anion transporter 9; solute carrier family 22 member 27 isoform 1", "tax_id": 10090, "disease": "mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); Lynch syndrome (Disease Ontology:DOID:3883)", "pathway": " (mmu:171405)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20332632;31599954;34428180", "class_list": "", "function": "Does not appear to have transporter activity., [UniProtKB, PubMed]; Oat9S appears to be the first member to mediate the transport of carnitine and possesses eight transmembrane domains., [RefSeq, PubMed]; Sodium-independent organic anion transporter which exhibits high specificity for L-carnitine. Can also transport salicylic acid and the drug cimetidine., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q76M71", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity;GO:0015636 short-chain fatty acid transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0015711 organic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q76M72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TPE5-1", "uniprot_id": "S7A6O_MOUSE", "mass": 35041.0, "length": 306, "protein_name": "Probable RNA polymerase II nuclear localization protein SLC7A6OS", "gene_name": "Slc7a6os", "organism": "Mouse", "refseq_name": "probable RNA polymerase II nuclear localization protein SLC7A6OS", "refseq_ac": "NP_001007568", "gene_names_uniprotkb": "Slc7a6os", "gene_names_refseq": "2010007L18Rik; 2400002F02Rik; Slc7a6os", "protein_names_uniprotkb": "Probable RNA polymerase II nuclear localization protein SLC7A6OS; Solute carrier family 7 member 6 opposite strand transcript homolog", "protein_names_refseq": "probable RNA polymerase II nuclear localization protein SLC7A6OS; protein SLC7A6OS; solute carrier family 7 member 6 opposite strand transcript homolog", "tax_id": 10090, "disease": "progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (mmu:66432)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17242355;21183079;34428180", "class_list": "", "function": "Directs RNA polymerase II nuclear import., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0032502 developmental process;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TPE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGF9-1", "uniprot_id": "S2544_MOUSE", "mass": 35339.0, "length": 314, "protein_name": "Solute carrier family 25 member 44", "gene_name": "Slc25a44", "organism": "Mouse", "refseq_name": "solute carrier family 25 member 44 isoform b", "refseq_ac": "NP_001139348", "gene_names_uniprotkb": "Slc25a44", "gene_names_refseq": "6720482A19; B430110G05Rik; Slc25a44", "protein_names_uniprotkb": "Solute carrier family 25 member 44", "protein_names_refseq": "solute carrier family 25 member 44 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:229517)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "25428506;25428507;30084848;30779550;31435015;33944778;34428180", "class_list": "", "function": "Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial solute transporter which transports branched-chain amino acid (BCAA; valine, leucine and isoleucine) into mitochondria in brown adipose tissue (BAT) (PubMed:31435015). BAT is involved in BCAA catabolism and actively utilizes BCAA in the mitochondria for thermogenesis (PubMed:31435015)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSU9", "ec_number_list": "", "go_molecular_function": "GO:0015658 branched-chain amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0009083 branched-chain amino acid catabolic process;GO:0006865 amino acid transport;GO:0015803 branched-chain amino acid transport;GO:0120161 regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BGF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHK3-1", "uniprot_id": "S36A2_MOUSE", "mass": 52063.0, "length": 478, "protein_name": "Proton-coupled amino acid transporter 2", "gene_name": "Slc36a2", "organism": "Mouse", "refseq_name": "proton-coupled amino acid transporter 2", "refseq_ac": "NP_694810", "gene_names_uniprotkb": "Slc36a2; Pat2; Tramd1", "gene_names_refseq": "A530067G19Rik; PAT2; Slc36a2; Tramd1", "protein_names_uniprotkb": "Proton-coupled amino acid transporter 2; Proton/amino acid transporter 2; Solute carrier family 36 member 2; Tramdorin-1; Transmembrane domain rich protein 1", "protein_names_refseq": "proton-coupled amino acid transporter 2; proton/amino acid transporter 2; solute carrier family 36 member 2; tramdorin 1 (transmembrane domain rich protein); tramdorin-1; transmembrane domain rich protein 1", "tax_id": 10090, "disease": "iminoglycinuria (Disease Ontology:DOID:0112265)", "pathway": " (mmu:246049); (R-MMU-352230); (R-MMU-428559)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11959859;12451123;12809675;14600155;15058382;15291811;22711289;25080478", "class_list": "", "function": "During the 14 day differentiation period the uptake of the prototype PAT2 substrate L-[(3)H]proline increased ~5-fold., [RefSeq, PubMed]; Electrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. Extension of the backbone length, as in beta-alanine and 4-aminobutanoate or methylation of the amino group, as in sarcosine and N,N-dimethylglycine, are also tolerated but decrease transport efficiency. A free carboxyl group is preferred., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The amino acid transporter PAT2 and the purinergic receptor P2RX5 are cell surface markers expressed in classical brown and beige adipocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUB0;Q8JZP1", "ec_number_list": "", "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0015187 glycine transmembrane transporter activity;GO:0015193 L-proline transmembrane transporter activity;GO:0005280 amino acid:proton symporter activity;GO:0005297 proline:proton symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0055038 recycling endosome membrane;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0010155 regulation of proton transport;GO:0015824 proline transport;GO:0035524 proline transmembrane transport;GO:0015808 L-alanine transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BHK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIJ7-1", "uniprot_id": "RUFY1_MOUSE", "mass": 80376.0, "length": 712, "protein_name": "RUN and FYVE domain-containing protein 1", "gene_name": "Rufy1", "organism": "Mouse", "refseq_name": "RUN and FYVE domain-containing protein 1", "refseq_ac": "NP_766145", "gene_names_uniprotkb": "Rufy1; Rabip4", "gene_names_refseq": "3000002E04Rik; Rabip4; Rufy1; ZFYVE12", "protein_names_uniprotkb": "RUN and FYVE domain-containing protein 1; Rab4-interacting protein", "protein_names_refseq": "FYVE-finger containing protein; RUN and FYVE domain-containing protein 1; Rab4a interacting protein; rab4-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:216724); (R-MMU-1660499)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11172003;11509568;16522682;17001082;25153642;30084848;34428180;38382525", "class_list": "", "function": "Activating adapter involved in cargo sorting from early/recycling endosomes (PubMed:11172003, PubMed:16522682). Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex. Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (By similarity). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:11509568). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (PubMed:38382525)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Rabip4 plays a role in the endocytotic trafficking of Glut4 in 3T3-L1 adipocytes., [RefSeq, PubMed]; Rabip4s, possibly via their interaction with Rab4, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKQ4;Q8BL21;Q9EPM6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0031901 early endosome membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0030100 regulation of endocytosis;GO:0007264 small GTPase-mediated signal transduction;GO:0034058 endosomal vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BIJ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJA2-1", "uniprot_id": "S41A1_MOUSE", "mass": 54928.0, "length": 512, "protein_name": "Solute carrier family 41 member 1", "gene_name": "Slc41a1", "organism": "Mouse", "refseq_name": "solute carrier family 41 member 1", "refseq_ac": "NP_776290", "gene_names_uniprotkb": "Slc41a1", "gene_names_refseq": "B230315F01Rik; Slc41a1", "protein_names_uniprotkb": "Solute carrier family 41 member 1", "protein_names_refseq": "solute carrier family 41 member 1", "tax_id": 10090, "disease": "nephronophthisis (Disease Ontology:DOID:12712); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:98396); (R-MMU-425410)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15713785;28222767;33153064;35163580;36049064", "class_list": "", "function": "Dietary Mg(2+) Intake and the Na(+)/Mg(2+) Exchanger SLC41A1 Influence Components of Mitochondrial Energetics in Murine Cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells. Publication Status: Online-Only, [RefSeq, PubMed]; Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters. Publication Status: Online-Only, [RefSeq, PubMed]; Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane. Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump. Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (By similarity). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (PubMed:33153064)., [UniProtKB, UniProtKB, PubMed]; SLC41A1 knockout mice display normal magnesium homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061768 magnesium:sodium antiporter activity;GO:0022857 transmembrane transporter activity;GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0015693 magnesium ion transport;GO:1903830 magnesium ion transmembrane transport;GO:0071286 cellular response to magnesium ion;GO:0030001 metal ion transport;GO:0010961 intracellular magnesium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BJA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BVN7-1", "uniprot_id": "S2541_MOUSE", "mass": 34505.0, "length": 312, "protein_name": "Calcium-independent mitochondrial carrier protein SCaMC-3L", "gene_name": "Slc25a41", "organism": "Mouse", "refseq_name": "calcium-independent mitochondrial carrier protein SCaMC-3L isoform 2", "refseq_ac": "NP_001333456", "gene_names_uniprotkb": "Slc25a41; SCaMC3L", "gene_names_refseq": "4933406J04Rik; SCaMC-3L; Slc25a41", "protein_names_uniprotkb": "Calcium-independent mitochondrial carrier protein SCaMC-3L; Mitochondrial ATP-Mg/Pi carrier protein SLC25A41; SCaMC-3-like; SCaMC-3L; Small calcium-binding mitochondrial carrier protein 3-like; Solute carrier family 25 member 41", "protein_names_refseq": "SCaMC-3-like; calcium-independent mitochondrial carrier protein SCaMC-3L isoform 2; calcium-independent mitochondrial carrier protein SCaMC-3L; mitochondrial ATP-Mg/Pi carrier protein SLC25A41; mitochondrial ATP-Mg/Pi carrier protein; small calcium-binding mitochondrial carrier protein 3-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:103775)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18928449", "class_list": "", "function": "Calcium-independent ATP-Mg/Pi exchanger that catalyzes the electroneutral exchange of Mg-ATP or free ADP against an hydrogenphosphate and participates in the net transport of adenine nucleotides across the mitochondria inner membrane., [UniProtKB, PubMed]; Mouse SCaMC-3L shows a limited expression pattern; it is preferentially expressed in testis and, at lower levels, in brain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8ZHC8;Q14BV4", "ec_number_list": "", "go_molecular_function": "GO:0005347 ATP transmembrane transporter activity;GO:0015217 ADP transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015866 ADP transport;GO:0015867 ATP transport;GO:0140021 mitochondrial ADP transmembrane transport;GO:1990544 mitochondrial ATP transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BVN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BY79-1", "uniprot_id": "S35G1_MOUSE", "mass": 40217.0, "length": 368, "protein_name": "Solute carrier family 35 member G1", "gene_name": "Slc35g1", "organism": "Mouse", "refseq_name": "solute carrier family 35 member G1", "refseq_ac": "NP_780716", "gene_names_uniprotkb": "Slc35g1; Tmem20", "gene_names_refseq": "D330039I19Rik; Slc35g1; Tmem20", "protein_names_uniprotkb": "Solute carrier family 35 member G1; Transmembrane protein 20", "protein_names_refseq": "solute carrier family 35 member G1; transmembrane protein 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:240660)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "28572627;31219806;35820727;37393044", "class_list": "", "function": "Chloride-sensitive citrate transporter localized on the basolateral membrane of enterocytes that mediates efflux of citrate into the bloodstream. May also play a role in intracellular calcium sensing and homeostasis by acting as a negative regulator of plasma membrane calcium-transporting ATPases, thereby preventing calcium efflux from the cell., [UniProtKB, UniProtKB]; Discovery and Validation of Novel Genes in a Large Chinese Autism Spectrum Disorder Cohort., [RefSeq, PubMed]; Study shows that microRNA-150 modulates intracellular Ca (2+) levels in naive CD8(+) T cells by targeting transmembrane protein 20. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RPY9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:1990034 calcium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BY79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZH0-1", "uniprot_id": "S39AD_MOUSE", "mass": 38502.0, "length": 361, "protein_name": "Zinc transporter ZIP13", "gene_name": "Slc39a13", "organism": "Mouse", "refseq_name": "zinc transporter ZIP13 isoform a precursor", "refseq_ac": "NP_001277694", "gene_names_uniprotkb": "Slc39a13; Zip13", "gene_names_refseq": "1100001L14Rik; Slc39a13; ZIP-13; ZIP13", "protein_names_uniprotkb": "Zinc transporter ZIP13; Solute carrier family 39 member 13; ZIP-13; Zrt- and Irt-like protein 13", "protein_names_refseq": "solute carrier family 39 member 13; zinc transporter ZIP13 isoform a precursor; zinc transporter ZIP13; zrt- and Irt-like protein 13", "tax_id": 10090, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); Ehlers-Danlos syndrome spondylodysplastic type 3 (Disease Ontology:DOID:0080739); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359)", "pathway": " (mmu:68427)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18985159;21750661;26050750;28854265;31219806;33307093;38609428", "class_list": "", "function": "Downregulation of the zinc transporter SLC39A13 (ZIP13) is responsible for the activation of CaMKII at reperfusion and leads to myocardial ischemia/reperfusion injury in mouse hearts., [RefSeq, PubMed]; Functions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol (PubMed:18985159). May regulate beige adipocyte differentiation (PubMed:28854265)., [UniProtKB, PubMed, PubMed]; Possible involvement of zinc transporter ZIP13 in myogenic differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; The Slc39a13-KO mouse represents a novel animal model linking zinc metabolism, BMP/TGF-beta signaling and connective tissue dysfunction. Erratum:[PLoS One. 2008;3(11). doi: 10.1371/annotation/a6c35a12-e8eb-43a0-9d00-5078fa6da1bb], [RefSeq, PubMed]; This study concluded that skin fragility due to defective ZIP13 protein may be attributable to impaired extracellular matrix synthesis accompanied by abnormal peripheral TGF-beta homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7ZCF2;Q497M5;Q8VDX1;Q9D1R4", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0050873 brown fat cell differentiation;GO:0006882 intracellular zinc ion homeostasis;GO:0061448 connective tissue development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BZH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZK4-1", "uniprot_id": "S35F4_MOUSE", "mass": 53704.0, "length": 485, "protein_name": "Solute carrier family 35 member F4", "gene_name": "Slc35f4", "organism": "Mouse", "refseq_name": "solute carrier family 35 member F4", "refseq_ac": "NP_083514", "gene_names_uniprotkb": "Slc35f4; MNCb-0335", "gene_names_refseq": "4930550L21Rik; Slc35f4", "protein_names_uniprotkb": "Solute carrier family 35 member F4", "protein_names_refseq": "solute carrier family 35 member F4", "tax_id": 10090, "disease": "", "pathway": " (mmu:75288)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Mediates choline transport, although the underlying transport mechanism remains to be elucidated., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JJY8;Q8BL81;Q8BXC4;Q9JJG8", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0015220 choline transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015871 choline transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BZK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C8C1-1", "uniprot_id": "RTP1_MOUSE", "mass": 30732.0, "length": 263, "protein_name": "Receptor-transporting protein 1", "gene_name": "Rtp1", "organism": "Mouse", "refseq_name": "receptor-transporting protein 1", "refseq_ac": "NP_001004151", "gene_names_uniprotkb": "Rtp1; Gm604", "gene_names_refseq": "Gm1766; Gm604; Rtp1", "protein_names_uniprotkb": "Receptor-transporting protein 1", "protein_names_refseq": "receptor-transporting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:239766)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15550249;31395660", "class_list": "", "function": "Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs., [UniProtKB, PubMed]; Using recombinant proteins and split luciferase assays in mammalian cells, we provided evidence for the dimer formation of RTP1S. Furthermore, we determined that the 2nd Cys residue is required for the efficient dimerization of RTP1S. Altogether, these findings provide insights into the mechanism for plasma membrane transport of odorant receptors (ORs) by RTP1S., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031849 olfactory receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0051205 protein insertion into membrane;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C8C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K352-1", "uniprot_id": "SASH3_MOUSE", "mass": 41609.0, "length": 380, "protein_name": "SAM and SH3 domain-containing protein 3", "gene_name": "Sash3", "organism": "Mouse", "refseq_name": "SAM and SH3 domain-containing protein 3 isoform 1", "refseq_ac": "NP_001300678", "gene_names_uniprotkb": "Sash3; Sly", "gene_names_refseq": "1200013B08Rik; SLY1; Sash3", "protein_names_uniprotkb": "SAM and SH3 domain-containing protein 3; SH3 protein expressed in lymphocytes", "protein_names_refseq": "Novel SH3 and SAM domain containing protein; SAM and SH3 domain-containing protein 3 isoform 1; SAM and SH3 domain-containing protein 3; SH3 protein expressed in lymphocytes", "tax_id": 10090, "disease": "immunodeficiency 102 (Disease Ontology:DOID:0061072)", "pathway": " (mmu:74131)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11470164;16227612;18950867;19604361;21183079;26306874;30631134;30759861;33876203;36401605", "class_list": "", "function": "Anti-apoptotic protein required for T cell differentiation to the CD4+CD8+ stage, likely to be involved in mTOR complex activation Publication Status: Online-Only, [RefSeq, PubMed]; Expression of the Notch signaling mediator RBP-J and the Notch target genes Hes-1 and Hes-5 was markedly reduced in MZ but not FO B cells of Sly1(d/d) mice., [RefSeq, PubMed]; In this report, the structure of the SLy1 SAM domain was solved and revealed that this SAM domain forms a symmetric homodimer through a novel interface. The interface consists primarily of the two long C-terminal helices, alpha5 and alpha5', of the domains packing against each other. Publication Status: Online-Only, [RefSeq, PubMed]; Knockout of SLy1 decreases double-negative thymocyte proliferation and protects mice from p53-induced tumor formation., [RefSeq, PubMed]; May function as a signaling adapter protein in lymphocytes., [UniProtKB, PubMed]; SASH3 variants cause a novel form of X-linked combined immunodeficiency with immune dysregulation., [RefSeq, PubMed]; Sly1 is an essential molecular component for the full activation of adaptive immunity, [RefSeq, PubMed]; This study describes SLy1 as an immunoregulatory protein, which is involved in the generation of adaptive immune responses during L. monocytogenes infection, and provides a model of how SLy1 regulates T-cell proliferation., [RefSeq, PubMed]; We also carried out transgene rescue by adding Sly1/2 transgenes to mice with NPYq deletions. We demonstrated that SLY1/2 expression in mutant mice decreased proportionally to deletion size, with ~12% of SLY1/2 retained in shSLY sh367 testes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBX0;Q9DBV2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048873 homeostasis of number of cells within a tissue;GO:0030890 positive regulation of B cell proliferation;GO:0032760 positive regulation of tumor necrosis factor production;GO:0002726 positive regulation of T cell cytokine production;GO:0032729 positive regulation of type II interferon production", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K352-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC69-1", "uniprot_id": "S22A6_MOUSE", "mass": 60013.0, "length": 545, "protein_name": "Solute carrier family 22 member 6", "gene_name": "Slc22a6", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 6", "refseq_ac": "NP_032792", "gene_names_uniprotkb": "Slc22a6; Nkt; Oat1", "gene_names_refseq": "NKT; Oat1; Orctl1; Slc22a6; mOat1", "protein_names_uniprotkb": "Solute carrier family 22 member 6; Kidney-specific transport protein; Novel kidney transcript; Organic anion transporter 1; Renal organic anion transporter 1; mNKT; mOAT1; mROAT1", "protein_names_refseq": "kidney-specific transport protein; mNKT; mROAT1; novel kidney transcript; organic anion transporter 1; organic cationic transporter-like 1; renal organic anion transporter 1; solute carrier family 22 member 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:18399); (R-MMU-561048)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10744714;14749323;14979872;15944205;25428506;30779550;33757768;33785360;35169129;36692015;37937647;9045672;9880528", "class_list": "", "function": "A key role for the transporter OAT1 in systemic lipid metabolism., [RefSeq, PubMed]; Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3., [RefSeq, PubMed]; Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Remote effects of kidney drug transporter OAT1 on gut microbiome composition and urate homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate (PubMed:15944205). Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine (By similarity). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (By similarity). Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion (By similarity). Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) (PubMed:15944205). May transport glutamate. Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body (By similarity). Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA) and 3-carboxy-4- methyl-5-propyl-2-furanpropionate(CMPF) and urate (By similarity). Xenobiotics include the mycotoxin ochratoxin (OTA) (By similarity). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier (By similarity)., [UniProtKB, UniProtKB, PubMed]; The kidney drug transporter OAT1 regulates gut microbiome-dependent host metabolism. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q61185", "ec_number_list": "", "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0042802 identical protein binding;GO:0031404 chloride ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005901 caveola;GO:0009925 basal plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0072237 metanephric proximal tubule development;GO:0051260 protein homooligomerization;GO:0015711 organic anion transport;GO:0043252 sodium-independent organic anion transport;GO:0006820 monoatomic anion transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8VC69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921R8-1", "uniprot_id": "S41A3_MOUSE", "mass": 53257.0, "length": 488, "protein_name": "Solute carrier family 41 member 3", "gene_name": "Slc41a3", "organism": "Mouse", "refseq_name": "solute carrier family 41 member 3 isoform 2", "refseq_ac": "NP_001032570", "gene_names_uniprotkb": "Slc41a3", "gene_names_refseq": "1010001P06Rik; SLC41A1-L2; Slc41a3", "protein_names_uniprotkb": "Solute carrier family 41 member 3", "protein_names_refseq": "solute carrier family 41 member 3 isoform 2", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:71699)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;27349617", "class_list": "", "function": "Acts as a magnesium transporter., [UniProtKB, UniProtKB]; Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the mitochondrial inner membrane., [UniProtKB, UniProtKB]; SLC41A3 was established as a new factor for Mg(2+) handling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DC67", "ec_number_list": "", "go_molecular_function": "GO:0061768 magnesium:sodium antiporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0045016 mitochondrial magnesium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q921R8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQK7-1", "uniprot_id": "RWDD1_MOUSE", "mass": 27785.0, "length": 243, "protein_name": "RWD domain-containing protein 1", "gene_name": "Rwdd1", "organism": "Mouse", "refseq_name": "RWD domain-containing protein 1", "refseq_ac": "NP_079890", "gene_names_uniprotkb": "Rwdd1; Dfrp2", "gene_names_refseq": "0710001K08Rik; 2610002D06Rik; 2700069A07Rik; IH1; Rwdd1", "protein_names_uniprotkb": "RWD domain-containing protein 1; DRG family-regulatory protein 2; IH1", "protein_names_refseq": "DRG family-regulatory protein 2; RWD domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66521); (R-MMU-9629569)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15676025;18761815;18954556;22406838", "class_list": "", "function": "Data describe a new role for RWDD1 as androgen receptor (AR) coactivator; RWDD1 interacts with the androgen receptor in vitro and in vivo; AR ligand-binding dis sufficient for the interaction with RWDD1., [RefSeq, PubMed]; Protects DRG2 from proteolytic degradation (PubMed:15676025). May function as a coactivator of the AR/androgen receptor transcription factor during development (PubMed:18761815, PubMed:22406838)., [UniProtKB, PubMed, PubMed, PubMed]; Rwdd1 is a novel member of the IUP family., [RefSeq, PubMed]; Rwdd1 is a thymus involution related protein that may indirectly affect androgen receptor signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030521 androgen receptor signaling pathway;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D321-1", "uniprot_id": "S35A4_MOUSE", "mass": 34695.0, "length": 324, "protein_name": "Probable UDP-sugar transporter protein SLC35A4", "gene_name": "Slc35a4", "organism": "Mouse", "refseq_name": "probable UDP-sugar transporter protein SLC35A4", "refseq_ac": "NP_001076786", "gene_names_uniprotkb": "Slc35a4", "gene_names_refseq": "2610030J16Rik; Slc35a4", "protein_names_uniprotkb": "Probable UDP-sugar transporter protein SLC35A4; Solute carrier family 35 member A4", "protein_names_refseq": "probable UDP-sugar transporter protein SLC35A4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67843); (R-MMU-9939291)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene", "function": "Mediates the transport of CDP-ribitol (By similarity). Does not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine transport activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 72, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMH3;Q99JK8;Q9D0A7", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5K4-1", "uniprot_id": "S1PBP_MOUSE", "mass": 44473.0, "length": 396, "protein_name": "S100P-binding protein", "gene_name": "S100pbp", "organism": "Mouse", "refseq_name": "S100P-binding protein isoform 2", "refseq_ac": "NP_001334132", "gene_names_uniprotkb": "S100pbp", "gene_names_refseq": "4930429A08Rik; S100pbpr; S100pbp", "protein_names_uniprotkb": "S100P-binding protein", "protein_names_refseq": "S100P-binding protein isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74648)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;37794133", "class_list": "", "function": "S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A7S5;Q3UJU0;Q3UTU1;Q3V367;Q8BSS8;Q8C925;Q8CHX8", "ec_number_list": "", "go_molecular_function": "GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D5K4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9X8-1", "uniprot_id": "SACA3_MOUSE", "mass": 25020.0, "length": 221, "protein_name": "Sperm acrosome membrane-associated protein 3", "gene_name": "Spaca3", "organism": "Mouse", "refseq_name": "sperm acrosome membrane-associated protein 3 precursor", "refseq_ac": "NP_083643", "gene_names_uniprotkb": "Spaca3; Lyc3; Lyzl3; Sllp1", "gene_names_refseq": "1700025M08Rik; ALLP17; Lyc3; SLLP1; Spaca3; mSLLP1", "protein_names_uniprotkb": "Sperm acrosome membrane-associated protein 3; Lysozyme-like protein 3; Sperm lysozyme-like protein 1; mSLLP1", "protein_names_refseq": "acrosomal sperm protein; lysozyme-like protein 3; sperm acrosome membrane-associated protein 3 precursor; sperm acrosome membrane-associated protein 3; sperm c-type lysozyme-like protein; sperm lysozyme-like protein 1 precusor", "tax_id": 10090, "disease": "viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (mmu:75622)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15982649;16014814;22206759;25038051;26198801", "class_list": "glycogene;glycosylhydrolase", "function": "Data show that SAS1B/SAS1R (Sperm Acrosomal SLLP1 Binding/Sperm Acrosomal SLLP1 receptor) bound to sperm acrosomal protein SlLP1 with high affinity., [RefSeq, PubMed]; Distinct from c-lysozyme by substituting two essential catalytic residues (E35T/D52N), and by forming helical filaments approximately 75 A in diameter with a 25 A central pore comprised of six monomers per helix turn repeating every 33 A, [RefSeq, PubMed]; Female mice immunized with SPRASA had profound infertility following timed matings and those mice that did become pregnant had reduced fetal viability., [RefSeq, PubMed]; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro (By similarity)., [UniProtKB, PubMed]; This study demonstrates the retention of mouse sperm lysozyme-like protein (mSLLP1) in the equatorial segment of spermatozoa following the acrosome reaction and a role for mSLLP1 in sperm-egg binding and fertilization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SUU3;Q6PKP1;Q6PX67", "ec_number_list": "", "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0030141 secretory granule;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D9X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHI4-1", "uniprot_id": "S13A1_MOUSE", "mass": 66084.0, "length": 594, "protein_name": "Solute carrier family 13 member 1", "gene_name": "Slc13a1", "organism": "Mouse", "refseq_name": "solute carrier family 13 member 1", "refseq_ac": "NP_062354", "gene_names_uniprotkb": "Slc13a1; Nas1; Nasi1", "gene_names_refseq": "NaSi-1; Nas1; Slc13a1", "protein_names_uniprotkb": "Solute carrier family 13 member 1; Na(+)/sulfate cotransporter; NaSi-1; Renal sodium/sulfate cotransporter", "protein_names_refseq": "Na(+)/sulfate cotransporter; renal sodium/sulfate cotransporter; solute carrier family 13 (sodium/sulphate symporters), member 1; solute carrier family 13 member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:55961); (R-MMU-433137)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10766815;12111243;12139403;14578452", "class_list": "", "function": "1,25-(OH)(2)D(3)- and T(3)-responsive element was identified within the Nas1 promoter., [RefSeq, PubMed]; NaSi-1 is essential for maintaining sulfate homeostasis, and its expression is necessary for a wide range of physiological functions, [RefSeq, PubMed]; Sodium:sulfate symporter that mediates sulfate reabsorption in the kidney and small intestine (PubMed:10766815). Can also mediate the transport of selenate and thiosulfate (By similarity)., [UniProtKB, PubMed, UniProtKB]; This protein is a functional sulfate transporter in the kidney and intestine Review article, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80YB5;Q8R208;Q9D2C3", "ec_number_list": "", "go_molecular_function": "GO:0015382 sodium:sulfate symporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015373 monoatomic anion:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006814 sodium ion transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JHI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0L1-1", "uniprot_id": "S1PR4_MOUSE", "mass": 42263.0, "length": 386, "protein_name": "Sphingosine 1-phosphate receptor 4", "gene_name": "S1pr4", "organism": "Mouse", "refseq_name": "sphingosine 1-phosphate receptor 4", "refseq_ac": "NP_034232", "gene_names_uniprotkb": "S1pr4; Edg6; Lpc1; S1p4", "gene_names_refseq": "Edg6; Lpc1; S1p4; S1pr4", "protein_names_uniprotkb": "Sphingosine 1-phosphate receptor 4; Endothelial differentiation G protein-coupled receptor 6; Lysophospholipid receptor C1; S1P receptor 4; S1P receptor Edg-6; S1P4; Sphingosine 1-phosphate receptor Edg-6", "protein_names_refseq": "S1P receptor Edg-6; S1p receptor 4; endothelial differentiation G-protein-coupled receptor 6; lysophospholipid receptor C1; sphingosine 1-phosphate receptor 4; sphingosine 1-phosphate receptor Edg-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:13611); (R-MMU-418594); (R-MMU-419408)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12401211;34428180;37056936;37657263;39007959;39188715;9790765", "class_list": "", "function": "Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4., [RefSeq, PubMed]; G protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production. Functions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). Upon S1P binding, promotes regulatory T-cell differentiation and enhances fatty acid oxidation, through activation of the NRF2/PPARA signaling pathway (PubMed:39007959). Modulates also M1 macrophage activation through interaction with FPR2 and the JNK signaling, thereby contributing to the inflammatory response (PubMed:37056936). In addition, facilitates early neutrophil mobilization and vascular activation during inflammation, promoting lymphocyte recruitment to draining lymph nodes and supporting the development of germinal centers for an effective adaptive immune response (PubMed:39188715)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; S1p(4) maps to mouse chromosome 10 and has similar tissue distribution to mouse Gna15; transcription of the two genes may be under control of the same enhancer elements, [RefSeq, PubMed]; Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation. Publication Status: Online-Only, [RefSeq, PubMed]; Sphingosine-1-Phosphate Receptor 4 links neutrophils and early local inflammation to lymphocyte recruitment into the draining lymph node to facilitate robust germinal center formation. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The encoded protein is one of the predominant sphingosine 1-phosphate G-protein coupled receptors expressed in T cells, and it plays a role in suppression of T cell proliferation, generation of cytokines, and potentially other aspects of immune activation. [provided by RefSeq, Feb 2010]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4H3;Q8C6E2;Q8K1R9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038036 sphingosine-1-phosphate receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z0L1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61263-1", "uniprot_id": "SOAT1_MOUSE", "mass": 63799.0, "length": 540, "protein_name": "Sterol O-acyltransferase 1", "gene_name": "Soat1", "organism": "Mouse", "refseq_name": "sterol O-acyltransferase 1", "refseq_ac": "NP_033256", "gene_names_uniprotkb": "Soat1; Acact", "gene_names_refseq": "8430426K15Rik; ACAT-1; Acact; Soat1; ald; hid", "protein_names_uniprotkb": "Sterol O-acyltransferase 1; 2.3.1.26; ACAT-1; Acyl-coenzyme A:cholesterol acyltransferase 1; Cholesterol acyltransferase 1", "protein_names_refseq": "acyl-coenzyme A:cholesterol acyltransferase 1; adrenocortical lipid depletion; cholesterol acyltransferase 1; sterol O-acyltransferase 1", "tax_id": 10090, "disease": "Chagas disease (Disease Ontology:DOID:12140)", "pathway": " (mmu:20652); (R-MMU-8964038)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11071899;21750661;25428506;30084848;31219806;31599954;34428180;37585190;38761895;38953847;7592824;8579615", "class_list": "", "function": "Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as a substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions., [UniProtKB, UniProtKB]; Comparative Biophysical Study of Meibomian Lipids of Wild Type and Soat1-Null Mice: Implications to Meibomian Gland Dysfunction and Dry Eye Disease., [RefSeq, PubMed]; Physiological Effects of Soat1 Inactivation on Homeostasis of the Mouse Ocular Surface., [RefSeq, PubMed]; Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XK32;Q64180", "ec_number_list": "2.3.1.26", "go_molecular_function": "GO:0042802 identical protein binding;GO:0015485 cholesterol binding;GO:0000062 fatty-acyl-CoA binding;GO:0004772 sterol O-acyltransferase activity;GO:0034736 cholesterol O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010742 macrophage derived foam cell differentiation;GO:0008203 cholesterol metabolic process;GO:0033344 cholesterol efflux;GO:0034379 very-low-density lipoprotein particle assembly;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61263-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61900-1", "uniprot_id": "SMR3A_MOUSE", "mass": 15544.0, "length": 147, "protein_name": "Submaxillary gland androgen-regulated protein 3A", "gene_name": "Smr3a", "organism": "Mouse", "refseq_name": "submaxillary gland androgen-regulated protein 3A precursor", "refseq_ac": "NP_035552", "gene_names_uniprotkb": "Smr3a; Msg1; Smr1", "gene_names_refseq": "MSG1; MSG3; Smr1; Smr3a; Smr3", "protein_names_uniprotkb": "Submaxillary gland androgen-regulated protein 3A; Salivary protein MSG1; Submaxillary gland androgen-regulated protein 1", "protein_names_refseq": "salivary protein MSG1; submaxillary gland androgen regulated protein 3; submaxillary gland androgen-regulated protein 1; submaxillary gland androgen-regulated protein 3A precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:20599)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;24803544;8194749", "class_list": "", "function": "In corporal smooth muscle cells from a sickle-cell-disese mouse, there was Smr3a up-regulation at a life stage prior to priapism, so the changes in gene expression are unlikely due to priapism, but rather due to the hypoxic conditions in SCD., [RefSeq, PubMed]; May play a role in protection or detoxification., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7ZP11", "ec_number_list": "", "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0051930 regulation of sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q61900-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70124-1", "uniprot_id": "SPB5_MOUSE", "mass": 42111.0, "length": 375, "protein_name": "Serpin B5", "gene_name": "Serpinb5", "organism": "Mouse", "refseq_name": "serpin B5 isoform a", "refseq_ac": "NP_033283", "gene_names_uniprotkb": "Serpinb5; Pi5; Spi5; Spi7", "gene_names_refseq": "1110036M19Rik; Maspin; PI-5; Serpinb5; Spi7; ovalbumin", "protein_names_uniprotkb": "Serpin B5; Maspin; PI-5; Peptidase inhibitor 5", "protein_names_refseq": "peptidase inhibitor 5; protease inhibitor 5; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5; serine (or cysteine) proteinase inhibitor, clade B, member 5; serine protease inhibitor 7; serpin B5 isoform a; serpin B5", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:20724)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;27923833;30786218;31228474;34428180;9132279", "class_list": "", "function": "Maspin is a powerful context-dependent tumor suppressor., [RefSeq, PubMed]; Model of apoptosis in which maspin binds to cardiolipin, displaces cytochrome c from the membrane, and facilitates its release to the cytoplasm., [RefSeq, PubMed]; This is the first study to recognize the potential implication of maspin in the pathophysiology of asthma, [RefSeq, PubMed]; Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULZ0", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0045177 apical part of cell;GO:0001533 cornified envelope", "go_biological_process": "GO:0050678 regulation of epithelial cell proliferation;GO:0030198 extracellular matrix organization;GO:0002009 morphogenesis of an epithelium;GO:0060512 prostate gland morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70124-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMJ8-1", "uniprot_id": "SP8_MOUSE", "mass": 48417.0, "length": 486, "protein_name": "Transcription factor Sp8", "gene_name": "Sp8", "organism": "Mouse", "refseq_name": "transcription factor Sp8 isoform 2", "refseq_ac": "NP_796056", "gene_names_uniprotkb": "Sp8", "gene_names_refseq": "D930049B17Rik; Sp8; mBtd", "protein_names_uniprotkb": "Transcription factor Sp8", "protein_names_refseq": "transcription factor Sp8 isoform 2; transcription factor Sp8", "tax_id": 10090, "disease": "", "pathway": " (mmu:320145)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14526104;15358670;21750661", "class_list": "", "function": "Observations indicate that Sp8 functions downstream of Wnt3, Fgf10, and Bmpr1a in the signaling cascade that mediates apical ectodermal ridge formation, [RefSeq, PubMed]; Sp8 and Sp9, via Fgf8, are involved in mediating the actions of Fgf10 and Wnt/beta-catenin signaling during vertebrate limb outgrowth., [RefSeq, PubMed]; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWA3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030326 embryonic limb morphogenesis;GO:0009954 proximal/distal pattern formation;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BMJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2KF29-1", "uniprot_id": "SMKTR_MOUSE", "mass": 54619.0, "length": 484, "protein_name": "Sperm motility kinase Tcr mutant form", "gene_name": "Smoktcr", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Smoktcr", "gene_names_refseq": "", "protein_names_uniprotkb": "Sperm motility kinase Tcr mutant form; 2.7.11.1; Dominant negative form of Smok; Responder protein Smok-Tcr; SmokTcr; Tcr", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10647005", "class_list": "", "function": "While the main function of Smoks is to control sperm motility, the role of Smok-Tcr, with reduced kinase activity, is to counterbalance a signaling impairment caused by the distorter/sterility loci, giving t-sperm an advantage in reaching the oocytes. Transmission ratio distortion also called segregation distortion is the name given to the phenomenon above-mentioned. Being associated with the T-complex, it allows males heterozygous for a complete t-haplotype to preferentially transmit the t-haplotype chromosome., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2KF29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PXB6-1", "uniprot_id": "SFTA2_MOUSE", "mass": 8502.0, "length": 77, "protein_name": "Surfactant-associated protein 2", "gene_name": "Sfta2", "organism": "Mouse", "refseq_name": "surfactant-associated protein 2 precursor", "refseq_ac": "NP_001156666", "gene_names_uniprotkb": "Sfta2", "gene_names_refseq": "EG433102; Sfta2", "protein_names_uniprotkb": "Surfactant-associated protein 2; Surfactant-associated protein G", "protein_names_refseq": "surfactant-associated protein 2 precursor; surfactant-associated protein 2; surfactant-associated protein G", "tax_id": 10090, "disease": "", "pathway": " (mmu:433102)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22768197;35053244", "class_list": "", "function": "Putative surfactant protein., [UniProtKB]; SFTA2 was characterized as a novel unique secretory peptide highly expressed in the lung., [RefSeq, PubMed]; Surfactant Protein-G in Wildtype and 3xTg-AD Mice: Localization in the Forebrain, Age-Dependent Hippocampal Dot-like Deposits and Brain Content. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0030133 transport vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9PXB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70368-1", "uniprot_id": "SEBOX_MOUSE", "mass": 20391.0, "length": 190, "protein_name": "Homeobox protein SEBOX", "gene_name": "Sebox", "organism": "Mouse", "refseq_name": "homeobox protein SEBOX", "refseq_ac": "NP_032785", "gene_names_uniprotkb": "Sebox; Og9x", "gene_names_refseq": "OG9; Og9x; Sebox", "protein_names_uniprotkb": "Homeobox protein SEBOX; Homeobox OG-9; Skin-, embryo-, brain- and oocyte-specific homeobox", "protein_names_refseq": "OG9 homeobox; homeobox OG-9; homeobox protein SEBOX; skin-, embryo-, brain- and oocyte-specific homeobox", "tax_id": 10090, "disease": "", "pathway": " (mmu:18292)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10922053;18753614;21750661;25679966;8855241", "class_list": "", "function": "Probable transcription factor involved in the control of specification of mesoderm and endoderm., [UniProtKB]; Sebox is a new addition to maternal effect genes that produced and stored in oocytes and function in preimplantation embryo, [RefSeq, PubMed]; Sebox is important in preparing oocytes for embryonic development by orchestrating the expression of other important MEGs Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0006351 DNA-templated transcription;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P70368-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88908-1", "uniprot_id": "SOAT2_MOUSE", "mass": 60597.0, "length": 525, "protein_name": "Sterol O-acyltransferase 2", "gene_name": "Soat2", "organism": "Mouse", "refseq_name": "sterol O-acyltransferase 2", "refseq_ac": "NP_666176", "gene_names_uniprotkb": "Soat2; Acact-2; Acat2", "gene_names_refseq": "ACAT2; D15Wsu97e; Soat2", "protein_names_uniprotkb": "Sterol O-acyltransferase 2; 2.3.1.26; ACAT-2; Acyl-coenzyme A:cholesterol acyltransferase 2; Cholesterol acyltransferase 2", "protein_names_refseq": "ACAT-2; acyl-CoA:cholesterol acyltransferase; acyl-coenzyme A:cholesterol acyltransferase 2; cholesterol acyltransferase 2; sterol O-acyltransferase 2", "tax_id": 10090, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184); coronary artery disease (Disease Ontology:DOID:3393); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (mmu:223920); (R-MMU-8964038)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11071899;21750661;28604676;29184177;29878847;30630736;32890578;34428180;34982494;9756919", "class_list": "", "function": "Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa., [UniProtKB, UniProtKB]; Delineation of metabolic responses of Npc1(-/-nih) mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-beta-cyclodextrin., [RefSeq, PubMed]; Lipid-induced stabilization of ACAT2 ameliorates lipotoxicity from excessive cholesterol and fatty acid. This unconventional cysteine ubiquitylation of ACAT2 constitutes an important mechanism for sensing lipid-overload-induced ROS and fine-tuning lipid homeostasis. Erratum:[Nat Cell Biol. 2017 Nov 29;19(12):1441. doi: 10.1038/ncb3651. PMID: 29184177], [RefSeq, PubMed]; SOAT2 knockout in NPC1-deficient mice decreases hepatic cholesterol accumulation and improves liver function., [RefSeq, PubMed]; Soat2 ties cholesterol metabolism to beta-oxidation and glucose tolerance in male mice., [RefSeq, PubMed]; The study found that Soat2-/- mice fed high-fat, low-cholesterol diet to have less hepatic steatosis, decreased expression of genes involved in de novo lipogenesis and lower hepatic GLUT2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0Y9", "ec_number_list": "2.3.1.26", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0000062 fatty-acyl-CoA binding;GO:0004772 sterol O-acyltransferase activity;GO:0034736 cholesterol O-acyltransferase activity;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005903 brush border;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0033344 cholesterol efflux;GO:0034379 very-low-density lipoprotein particle assembly;GO:0042632 cholesterol homeostasis;GO:0010878 cholesterol storage", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O88908-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CBA2-1", "uniprot_id": "SLFN5_MOUSE", "mass": 100819.0, "length": 884, "protein_name": "Schlafen family member 5", "gene_name": "Slfn5", "organism": "Mouse", "refseq_name": "schlafen family member 5", "refseq_ac": "NP_899024", "gene_names_uniprotkb": "Slfn5", "gene_names_refseq": "Slfn5", "protein_names_uniprotkb": "Schlafen family member 5", "protein_names_refseq": "expressesd sequence AI956840; schlafen family member 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:327978)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15351786;21750661;24089532;31219806;34428180", "class_list": "", "function": "May have a role in hematopoietic cell differentiation., [UniProtKB, PubMed]; Several mouse Slfn genes are up-regulated in response to IFN treatment of mouse melanoma and renal cell carcinoma cells, including Slfn1, Slfn2, Slfn4, Slfn5, and Slfn8., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148Z1;Q3V3H0;Q5QNT5;Q7TMA8", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CBA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M742-1", "uniprot_id": "SG1C1_MOUSE", "mass": 10571.0, "length": 95, "protein_name": "Secretoglobin family 1C member 1", "gene_name": "Scgb1c1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Scgb1c1; Ryd5", "gene_names_refseq": "", "protein_names_uniprotkb": "Secretoglobin family 1C member 1; Secretoglobin RYD5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:338417)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12406855;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7M742-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q45HK4-1", "uniprot_id": "SH21C_MOUSE", "mass": 15044.0, "length": 132, "protein_name": "SH2 domain-containing protein 1B2", "gene_name": "Sh2d1b2", "organism": "Mouse", "refseq_name": "SH2 domain-containing protein 1B2", "refseq_ac": "NP_001028671", "gene_names_uniprotkb": "Sh2d1b2; Eat2b; Sh2d1c", "gene_names_refseq": "EAT-2B; Eat2b; Ert; Sh2d1b2; Sh2d1c", "protein_names_uniprotkb": "SH2 domain-containing protein 1B2; EAT-2-related transducer; EAT-2B; ERT", "protein_names_refseq": "EAT-2-related transducer; SH2 domain protein 1B2; SH2 domain-containing protein 1B2", "tax_id": 10090, "disease": "", "pathway": " (mmu:545378)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16127454;16425036;20962259;21750661", "class_list": "", "function": "Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family. In SLAM signaling may cooperate with Sh2d1a/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through Cd244/2b4. However, conflicting results are reported which may reflect the use of different strain backgrounds. Proposed to act as an inhibitor of Cd244-mediated NK cell function including cytotoxicity and IFN-gamma production, the latter found also by triggering Klra4 and Klrk1 next to Cd244 (PubMed:16127454). Seems to positively regulate Cd244- and Cd84-dependent NK cell functions implicating Cd244-mediated phosphorylation of Vav1 (PubMed:20962259)., [UniProtKB, PubMed, PubMed]; EAT-2A and EAT-2B act as positive regulators of signaling lymphocyte activation molecule family receptor-specific NK cell functions in C57BL/6 mice., [RefSeq, PubMed]; Taken together, the data suggest that both EAT-2A and EAT-2B are adapters that recruit Src kinases to SLAM family receptors using a mechanism that is distinct from that of SAP., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q45GR3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0018108 peptidyl-tyrosine phosphorylation;GO:0002250 adaptive immune response;GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation;GO:0045953 negative regulation of natural killer cell mediated cytotoxicity;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q45HK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09164-1", "uniprot_id": "SODE_MOUSE", "mass": 27392.0, "length": 251, "protein_name": "Extracellular superoxide dismutase [Cu-Zn]", "gene_name": "Sod3", "organism": "Mouse", "refseq_name": "extracellular superoxide dismutase [Cu-Zn] precursor", "refseq_ac": "NP_035565", "gene_names_uniprotkb": "Sod3", "gene_names_refseq": "EC-SOD; Sod3", "protein_names_uniprotkb": "Extracellular superoxide dismutase [Cu-Zn]; 1.15.1.1; EC-SOD", "protein_names_refseq": "extracellular superoxide dismutase [Cu-Zn] precursor; extracellular superoxide dismutase", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); polyneuropathy (Disease Ontology:DOID:1389); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); oral cavity cancer (Disease Ontology:DOID:8618); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:20657); (R-MMU-3299685)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16371425;21573946;28011936;32152506;38141889;38851821;9163733;9376114", "class_list": "", "function": "Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen., [UniProtKB]; SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways., [RefSeq, PubMed]; SOD3 suppresses early cellular immune responses to parasite infection. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.15.1.1;1.8.-.-;1.11.1.-;1.7.-.-;1.14.12.-", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005507 copper ion binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005796 Golgi lumen", "go_biological_process": "GO:0001666 response to hypoxia;GO:0097746 blood vessel diameter maintenance;GO:0046688 response to copper ion;GO:0019430 removal of superoxide radicals", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "O09164-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54928-1", "uniprot_id": "SOCS5_MOUSE", "mass": 61086.0, "length": 536, "protein_name": "Suppressor of cytokine signaling 5", "gene_name": "Socs5", "organism": "Mouse", "refseq_name": "suppressor of cytokine signaling 5", "refseq_ac": "NP_062628", "gene_names_uniprotkb": "Socs5; Cish5", "gene_names_refseq": "1810018L08Rik; Cish5; Socs5; mKIAA0671", "protein_names_uniprotkb": "Suppressor of cytokine signaling 5; Cytokine-inducible SH2-containing protein 5; SOCS-5", "protein_names_refseq": "SOCS-5; cytokine inducible SH2-containing protein 5; suppressor of cytokine signaling 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:56468); (R-MMU-6785807); (R-MMU-8951664)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12242343;25428506;26173083;28196914;35820727;36366574;37828534;38267898;9419338", "class_list": "", "function": "Data show that the Japanese encephalitis virus (JEV)-induced expression of miR-301a led to inhibition of the production of the transcription factor IFN regulatory factor 1 (IRF1) and the signaling protein suppressor of cytokine signaling 5 (SOCS5). Publication Status: Online-Only, [RefSeq, PubMed]; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling., [UniProtKB, PubMed]; SOCS5 regulates Th1/Th2 cell balance and suppresses IL-4, [RefSeq, PubMed]; SOCS5, targeted by miR-155-5p, plays a negative regulatory role in pulmonary hypertension through inhibiting JAK2/STAT3 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Suppressor of Cytokine Signalling 5 (SOCS5) Modulates Inflammatory Responses during Alphavirus Infection. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSK1", "ec_number_list": "", "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0030971 receptor tyrosine kinase binding;GO:0019210 kinase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0032715 negative regulation of interleukin-6 production;GO:0050728 negative regulation of inflammatory response;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O54928-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88307-1", "uniprot_id": "SORL_MOUSE", "mass": 247086.0, "length": 2215, "protein_name": "Sortilin-related receptor", "gene_name": "Sorl1", "organism": "Mouse", "refseq_name": "sortilin-related receptor isoform 1 precursor", "refseq_ac": "NP_035566", "gene_names_uniprotkb": "Sorl1", "gene_names_refseq": "2900010L19Rik; LR11; SorLA; Sorl1; gp250; mSorLA", "protein_names_uniprotkb": "Sortilin-related receptor; Gp250; LDLR relative with 11 ligand-binding repeats; LR11; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; SorLA-1; Sorting protein-related receptor containing LDLR class A repeats; mSorLA", "protein_names_refseq": "LDLR relative with 11 ligand-binding repeats; low-density lipoprotein receptor relative with 11 ligand-binding repeats; sorLA-1; sortilin-related receptor isoform 1 precursor; sorting protein-related receptor containing LDLR class A repeats", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:20660)", "pathway_count": 1, "publication_count": 41, "publication_id_list": "10.1101/2023.09.13.557529;11082041;11180120;14764453;16075062;16174740;16407538;17322886;17332490;18250455;20007471;20385770;20485683;21385844;21913724;21994944;22645316;23333276;23386199;23486467;23977241;25428506;25967121;26495903;26584636;26740625;26858303;27322061;28011936;28265003;30084848;30679749;30899004;32069316;32152506;34428180;34779857;35984892;36055578;9510025;9726247", "class_list": "", "function": "SORLA is required for insulin-induced expansion of the adipocyte precursor pool in visceral fat., [RefSeq, PubMed]; SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition., [RefSeq, PubMed]; Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic reticulum to Golgi compartments (By similarity). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling by controlling the intracellular location of its receptor (PubMed:23977241). Sorting receptor for GDNF that promotes GDNF regulated, but not constitutive secretion (PubMed:21994944). Sorting receptor for the GDNF-GFRA1 complex, directing it from the cell surface to endosomes. GDNF is then targeted to lysosomes and degraded, while its receptor GFRA1 recycles back to the cell membrane, resulting in a GDNF clearance pathway. The SORL1-GFRA1 complex further targets RET for endocytosis, but not for degradation, affecting GDNF-induced neurotrophic activities (PubMed:23333276). Sorting receptor for ERBB2/HER2. Regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulating phosphoinositide 3-kinase (PI3K)-dependent ERBB2 signaling (By similarity). Sorting receptor for lipoprotein lipase LPL. Promotes LPL localization to endosomes and later to the lysosomes, leading to degradation of newly synthesized LPL (By similarity). Potential sorting receptor for APOA5, inducing APOA5 internalization to early endosomes, then to late endosomes, wherefrom a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network (By similarity). Sorting receptor for the insulin receptor INSR. Promotes recycling of internalized INSR via the Golgi apparatus back to the cell surface, thereby preventing lysosomal INSR catabolism, increasing INSR cell surface expression and strengthening insulin signal reception in adipose tissue. Does not affect INSR internalization (PubMed:27322061). Plays a role in renal ion homeostasis, controlling the phospho-regulation of SLC12A1/NKCC2 by STK39/SPAK kinase and PPP3CB/calcineurin A beta phosphatase, possibly through intracellular sorting of STK39 and PPP3CB (PubMed:20385770, PubMed:25967121). Stimulates, via the N-terminal ectodomain, the proliferation and migration of smooth muscle cells, possibly by increasing cell surface expression of the urokinase receptor uPAR/PLAUR. This may promote extracellular matrix proteolysis and hence facilitate cell migration (By similarity). By acting on the migration of intimal smooth muscle cells, may accelerate intimal thickening following vascular injury (PubMed:14764453). Promotes adhesion of monocytes (By similarity). Stimulates proliferation and migration of monocytes/macrophages. Through its action on intimal smooth muscle cells and macrophages, may accelerate intimal thickening and macrophage foam cell formation in the process of atherosclerosis (PubMed:17332490). Regulates hypoxia-enhanced adhesion of hematopoietic stem and progenitor cells to the bone marrow stromal cells via a PLAUR-mediated pathway. This function is mediated by the N-terminal ectodomain (PubMed:23486467). Metabolic regulator, which functions to maintain the adequate balance between lipid storage and oxidation in response to changing environmental conditions, such as temperature and diet. The N-terminal ectodomain negatively regulates adipose tissue energy expenditure, acting through the inhibition the BMP/Smad pathway (PubMed:26584636). Sorting receptor that may regulate signaling by the heterodimeric neurotrophic cytokine CLCF1-CRLF1 bound to the CNTFR receptor by promoting the endocytosis of the tripartite complex CLCF1-CRLF1-CNTFR and lysosomal degradation (PubMed:26858303). May regulate IL6 signaling, decreasing cis signaling, possibly by interfering with IL6-binding to membrane-bound IL6R, while up-regulating trans signaling via soluble IL6R (PubMed:28265003)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 19, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 19, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 19, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 19, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 25, "disease_count": 1, "glyco_site_count": 31, "binding_glycan_count": 0, "secondary_ac_list": "O54711;O70581;Q3UHM3", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0001540 amyloid-beta binding;GO:0031267 small GTPase binding;GO:0030169 low-density lipoprotein particle binding;GO:0019828 aspartic-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005641 nuclear envelope lumen;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:1902966 positive regulation of protein localization to early endosome;GO:1904179 positive regulation of adipose tissue development;GO:0045053 protein retention in Golgi apparatus;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 8.9, "record_id": "O88307-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16043-1", "uniprot_id": "SLIB_MOUSE", "mass": 12064.0, "length": 103, "protein_name": "Somatoliberin", "gene_name": "Ghrh", "organism": "Mouse", "refseq_name": "somatoliberin preproprotein", "refseq_ac": "NP_001316612", "gene_names_uniprotkb": "Ghrh", "gene_names_refseq": "GRF; Ghrf; Ghrh", "protein_names_uniprotkb": "Somatoliberin; GHRH; GRF; Growth hormone-releasing factor; Growth hormone-releasing hormone", "protein_names_refseq": "growth hormone-releasing factor; somatoliberin preproprotein; somatoliberin", "tax_id": 10090, "disease": "autoimmune polyendocrine syndrome type 1 (Disease Ontology:DOID:0050167); obstructive sleep apnea (Disease Ontology:DOID:0050848); isolated growth hormone deficiency type IA (Disease Ontology:DOID:0060873); prostate carcinoma (Disease Ontology:DOID:10286); prostatic hypertrophy (Disease Ontology:DOID:11132); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); endometriosis (Disease Ontology:DOID:289); renal cell carcinoma (Disease Ontology:DOID:4450); sleep disorder (Disease Ontology:DOID:535); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:14601); (R-MMU-418555); (R-MMU-420092)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "2481813;2514346", "class_list": "", "function": "GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone., [UniProtKB]; This gene encodes a hormone that has stimulatory effects on pituitary growth hormone synthesis and release, and somatotrope expansion. The encoded preproprotein undergoes proteolytic processing to generate the mature peptide that is secreted by hypothalamus. Mice lacking the encoded protein are deficient in the growth hormone, live longer and exhibit growth retardation, enhanced insulin sensitivity and increased xenobiotic metabolism. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031770 growth hormone-releasing hormone receptor binding;GO:0005184 neuropeptide hormone activity;GO:0051428 peptide hormone receptor binding;GO:0016608 growth hormone-releasing hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0043195 terminal bouton;GO:0043204 perikaryon;GO:0043679 axon terminus", "go_biological_process": "GO:0021984 adenohypophysis development;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation;GO:0032094 response to food", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P16043-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40224-2", "uniprot_id": "SDF1_MOUSE", "mass": 10561.0, "length": 93, "protein_name": "Stromal cell-derived factor 1", "gene_name": "Cxcl12", "organism": "Mouse", "refseq_name": "stromal cell-derived factor 1 isoform beta precursor", "refseq_ac": "NP_038683", "gene_names_uniprotkb": "Cxcl12; Sdf1", "gene_names_refseq": "Cxcl12; Pbsf; Scyb12; Sdf1; Tlsf; Tpar1", "protein_names_uniprotkb": "Stromal cell-derived factor 1; 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; C-X-C motif chemokine 12; PBSF; Pre-B cell growth-stimulating factor; SDF-1; TLSF; TPAR1; Thymic lymphoma cell-stimulating factor", "protein_names_refseq": "12-O-tetradecanoylphorbol 13-acetate repressed protein 1; chemokine (C-X-C motif) ligand 12; pre-B-cell growth-stimulating factor; stromal cell-derived factor 1 isoform beta precursor; stromal cell-derived factor 1; thymic lymphoma cell-stimulating factor", "tax_id": 10090, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); prostate cancer (Disease Ontology:DOID:10283); diabetic angiopathy (Disease Ontology:DOID:11713); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); larynx cancer (Disease Ontology:DOID:2596); breast carcinoma (Disease Ontology:DOID:3459); insulinoma (Disease Ontology:DOID:3892); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); periodontitis (Disease Ontology:DOID:824); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:20315); (R-MMU-376176); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "7982471;8134392;8342023;8757135", "class_list": "", "function": "Chemoattractant active on T-lymphocytes and monocytes but not neutrophils (By similarity). Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis (By similarity). Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for CXCL12/SDF-1 (By similarity). Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (By similarity). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase (By similarity). Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins (By similarity). CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase (By similarity). Plays a protective role after myocardial infarction (By similarity). Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation (PubMed:8757135). Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (PubMed:8134392)., [UniProtKB, PubMed, PubMed, UniProtKB]; This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FJL5;Q543V6", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008083 growth factor activity;GO:0008009 chemokine activity;GO:0042379 chemokine receptor binding;GO:0045236 CXCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:2000669 negative regulation of dendritic cell apoptotic process;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P40224-2", "record_type": "protein" }, { "uniprot_canonical_ac": "P43680-1", "uniprot_id": "SOX18_MOUSE", "mass": 40898.0, "length": 377, "protein_name": "Transcription factor SOX-18", "gene_name": "Sox18", "organism": "Mouse", "refseq_name": "transcription factor SOX-18", "refseq_ac": "NP_033262", "gene_names_uniprotkb": "Sox18; Sox-18", "gene_names_refseq": "Ragl; Ra; Sox18", "protein_names_uniprotkb": "Transcription factor SOX-18", "protein_names_refseq": "SRY-box containing gene 18; Sry-related HMG-box gene 18; ragged; transcription factor SOX-18", "tax_id": 10090, "disease": "hypotrichosis-lymphedema-telangiectasia-renal defect syndrome (Disease Ontology:DOID:0111360); hypotrichosis-lymphedema-telangiectasia syndrome (Disease Ontology:DOID:0111361)", "pathway": " (mmu:20672)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10742113;11094083;11130989;11554755;12748961;16895970;18931657;19429912;26939885;34428180;38417530;7651823;7665083", "class_list": "", "function": "TGF-beta1-Induced SOX18 Elevation Promotes Hepatocellular Carcinoma Progression and Metastasis Through Transcriptionally Upregulating PD-L1 and CXCL12., [RefSeq, PubMed]; Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis (PubMed:10742113, PubMed:12748961, PubMed:18931657, PubMed:19429912, PubMed:26939885, PubMed:7651823). Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers (PubMed:18931657, PubMed:26939885). Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells (PubMed:18931657). Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17 (PubMed:16895970). Interaction with MEF2C enhances transcriptional activation (PubMed:11554755). Besides, required for normal hair development (PubMed:11094083, PubMed:12748961)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UND6;Q9EQ73", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0060214 endocardium formation;GO:0061028 establishment of endothelial barrier;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0001570 vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P43680-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03734-1", "uniprot_id": "SPA3M_MOUSE", "mass": 47064.0, "length": 418, "protein_name": "Serine protease inhibitor A3M", "gene_name": "Serpina3m", "organism": "Mouse", "refseq_name": "serine protease inhibitor A3M isoform 1 precursor", "refseq_ac": "NP_033279", "gene_names_uniprotkb": "Serpina3m", "gene_names_refseq": "3e46; MMCM7; MMSPi2.4; Serpina3m; Spi-2l; Spi-2rs1; Spi2-rs1; Spi2.4; spi2", "protein_names_uniprotkb": "Serine protease inhibitor A3M; Serpin A3M", "protein_names_refseq": "alpha-1 antiproteinase; antitrypsin; serine (or cysteine) proteinase inhibitor, clade A, member 3M; serine protease inhibitor A3M isoform 1 precursor; serine protease inhibitor A3M; serine protease inhibitor-2 related sequence 1; serpin A3M", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); cystic fibrosis (Disease Ontology:DOID:1485); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); vasculitis (Disease Ontology:DOID:865)", "pathway": " (mmu:20717)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12659817;15638460;16944957;2049065;26740625;31219806;34428180;35984892;39627609;40997131", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9Q926;Q62260", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0034097 response to cytokine;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q03734-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04887-1", "uniprot_id": "SOX9_MOUSE", "mass": 56077.0, "length": 507, "protein_name": "Transcription factor SOX-9", "gene_name": "Sox9", "organism": "Mouse", "refseq_name": "transcription factor SOX-9", "refseq_ac": "NP_035578", "gene_names_uniprotkb": "Sox9; Sox-9", "gene_names_refseq": "2010306G03Rik; Sox9; mKIAA4243; mSox9", "protein_names_uniprotkb": "Transcription factor SOX-9; mSox9", "protein_names_refseq": "SRY-box containing gene 9; transcription factor SOX-9", "tax_id": 10090, "disease": "campomelic dysplasia (Disease Ontology:DOID:0050463); 46,XX sex reversal 2 (Disease Ontology:DOID:0111763); 46,XY sex reversal 10 (Disease Ontology:DOID:0111775); lung cancer (Disease Ontology:DOID:1324); lung carcinoma (Disease Ontology:DOID:3905)", "pathway": " (mmu:20682); (R-MMU-3769402); (R-MMU-8878166)", "pathway_count": 3, "publication_count": 36, "publication_id_list": "10319868;10805756;11120880;11371614;11857796;12105181;12414734;15132997;15529345;15694126;16203988;17525254;18415932;20940257;21212101;21367821;22421045;22510880;24191021;25229425;26146088;26150426;26527273;26910618;28263186;29644115;29659575;30021842;30084848;31121357;31382142;32103177;32317630;7704017;8441686;9119111", "class_list": "", "function": "Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:10319868, PubMed:11371614, PubMed:12414734, PubMed:15132997, PubMed:18415932, PubMed:20940257, PubMed:28263186). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:10805756, PubMed:12414734, PubMed:15694126, PubMed:17525254, PubMed:26146088, PubMed:26150426, PubMed:26910618, PubMed:28263186, PubMed:9119111). Also binds to some promoter regions (PubMed:20940257). Plays a central role in successive steps of chondrocyte differentiation (PubMed:11371614, PubMed:12414734, PubMed:22421045). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (PubMed:11371614, PubMed:12414734). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (PubMed:11371614, PubMed:12414734, PubMed:15529345). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (PubMed:22421045, PubMed:31121357). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (PubMed:21367821, PubMed:22421045). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (PubMed:32103177). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (PubMed:30021842). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (PubMed:29659575). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (PubMed:24191021). Controls epithelial branching during kidney development (PubMed:21212101)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7L2;Q91ZK2;Q99KQ0", "ec_number_list": "", "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0034236 protein kinase A catalytic subunit binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0046533 negative regulation of photoreceptor cell differentiation;GO:0001708 cell fate specification;GO:1904864 negative regulation of beta-catenin-TCF complex assembly;GO:2001054 negative regulation of mesenchymal cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q04887-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UMB5-1", "uniprot_id": "SMCR8_MOUSE", "mass": 104957.0, "length": 935, "protein_name": "Guanine nucleotide exchange protein SMCR8", "gene_name": "Smcr8", "organism": "Mouse", "refseq_name": "guanine nucleotide exchange protein SMCR8 isoform 1", "refseq_ac": "NP_001078909", "gene_names_uniprotkb": "Smcr8", "gene_names_refseq": "2310076G09Rik; D030073L15Rik; Smcr8", "protein_names_uniprotkb": "Guanine nucleotide exchange protein SMCR8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog", "protein_names_refseq": "guanine nucleotide exchange protein SMCR8 isoform 1; guanine nucleotide exchange protein SMCR8; smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:237782)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;11997338;17242355;21183079;22872234;25428506;27617292;27875531;30084848;30696333;30779550;31219806;31625563;31651360;31847700;34428180;38064514", "class_list": "", "function": "A key role of SMCR8 in regulating MTORC1 and AKT signaling and tissue homeostasis., [RefSeq, PubMed]; ALS-linked C9orf72-SMCR8 complex is a negative regulator of primary ciliogenesis., [RefSeq, PubMed]; C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis., [RefSeq, PubMed]; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27617292). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (By similarity). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292). As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro (By similarity). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (By similarity). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (By similarity)., [UniProtKB, UniProtKB, PubMed]; Study discovered that Smcr8 deficiency disrupts motor neurons axonal transport and lysosomal functions, leading to axonal swellings then motor behavior deficits in mice. The expression of Smcr8, like that of C9orf72, is reduced in mouse models and patient tissues. Smcr8 deficiency exacerbates axonal swellings and C9ALS/FTD gain of toxicity, providing new insights into the pathogenesis of C9ALS/FTD. Erratum:[Hum Mol Genet. 2020 Apr 15;29(6):1056. doi: 10.1093/hmg/ddaa012. PMID: 32057072], [RefSeq, PubMed]; These results demonstrate that the C9orf72-SMCR8 protein complex functions in the regulation of metabolism and provide evidence that loss of C9orf72 function may contribute to the pathogenesis of relevant diseases Publication Status: Online-Only, [RefSeq, PubMed]; We created Smcr8 knockout mice and found that Smcr8 mutant cells exhibit impaired autophagy induction, which is similarly observed in C9orf72 knockdown cells. Mechanistically, SMCR8/C9ORF72 interacts with the key autophagy initiation ULK1 complex and regulates expression and activity of ULK1 Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5U4H2;Q8BNG6;Q8C704", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0004860 protein kinase inhibitor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0098794 postsynapse;GO:0000785 chromatin;GO:0098793 presynapse", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0006351 DNA-templated transcription;GO:0010506 regulation of autophagy;GO:0010629 negative regulation of gene expression;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q3UMB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V0Y1-1", "uniprot_id": "P4R3C_MOUSE", "mass": 95416.0, "length": 813, "protein_name": "Protein PPP4R3C1", "gene_name": "Ppp4r3c1", "organism": "Mouse", "refseq_name": "protein PPP4R3C1", "refseq_ac": "NP_001029052", "gene_names_uniprotkb": "Ppp4r3c1; Ppp4r3cp; Smek3p", "gene_names_refseq": "4930415L06Rik; Ppp4r3c1; Ppp4r3cp; Ppp4r3c; Smek3p", "protein_names_uniprotkb": "Protein PPP4R3C1; SMEK homolog 3; Serine/threonine-protein phosphatase 4 regulatory subunit 3C", "protein_names_refseq": "Smek homolog 3; protein PPP4R3C1; protein PPP4R3C; putative SMEK homolog 3; serine/threonine-protein phosphatase 4 regulatory subunit 3C", "tax_id": 10090, "disease": "", "pathway": " (mmu:245511)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AG62", "ec_number_list": "", "go_molecular_function": "GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0030289 protein phosphatase 4 complex", "go_biological_process": "GO:0006974 DNA damage response;GO:2000779 regulation of double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3V0Y1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KL71-1", "uniprot_id": "SP2A3_MOUSE", "mass": 9408.0, "length": 83, "protein_name": "Small proline-rich protein 2A3", "gene_name": "Sprr2a3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sprr2a3", "gene_names_refseq": "", "protein_names_uniprotkb": "Small proline-rich protein 2A3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042514); (mmu:100303744); (mmu:20755)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "34735226", "class_list": "", "function": "Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (By similarity). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (PubMed:34735226). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0030141 secretory granule;GO:0030133 transport vesicle;GO:0001533 cornified envelope", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KL71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F289-1", "uniprot_id": "SPEM1_MOUSE", "mass": 35062.0, "length": 310, "protein_name": "Spermatid maturation protein 1", "gene_name": "Spem1", "organism": "Mouse", "refseq_name": "spermatid maturation protein 1", "refseq_ac": "NP_083131", "gene_names_uniprotkb": "Spem1", "gene_names_refseq": "1700095G12Rik; Spem1", "protein_names_uniprotkb": "Spermatid maturation protein 1", "protein_names_refseq": "sperm maturation 1; spermatid maturation protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74288)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17426145;20558241;21184802", "class_list": "", "function": "Interactions between RANBP17 and SPEM1, for the first time, point to a potential function of SPEM1 in the RANBP17-mediated nucleocytoplasmic transport., [RefSeq, PubMed]; Interactions between UBQLN1 and SPEM1 suggest a role in the regulation of protein ubiquitination during spermiogenesis., [RefSeq, PubMed]; Proper cytoplasm removal is a genetically regulated process requiring the participation of Spem1, a protein exclusively expressed in the cytoplasm of elongated (steps 14-16) spermatids in the mouse testis., [RefSeq, PubMed]; Required for proper cytoplasm removal during spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497J9;Q9D9D4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0007291 sperm individualization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5F289-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SUC9-1", "uniprot_id": "SCO1_MOUSE", "mass": 31617.0, "length": 284, "protein_name": "Cytochrome c oxidase assembly factor SCO1", "gene_name": "Sco1", "organism": "Mouse", "refseq_name": "cytochrome c oxidase assembly factor SCO1", "refseq_ac": "NP_001035115", "gene_names_uniprotkb": "Sco1", "gene_names_refseq": "2610001C07Rik; D11Bwg1310e; Sco1", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor SCO1", "protein_names_refseq": "SCO cytochrome oxidase deficient homolog 1; cytochrome c oxidase assembly factor SCO1; protein SCO1 homolog, mitochondrial", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); mitochondrial complex IV deficiency nuclear type 4 (Disease Ontology:DOID:0070493); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); neurodegenerative disease (Disease Ontology:DOID:1289); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); liver disease (Disease Ontology:DOID:409); mitochondrial metabolism disease (Disease Ontology:DOID:700); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:52892); (R-MMU-9864848)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "20864674;21750661;25683716;28647369;28973536;36261001", "class_list": "", "function": "Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Together with SCO2, involved in delivering copper to the Cu(A) site on MT-CO2/COX2 (By similarity). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (PubMed:25683716, PubMed:28973536)., [UniProtKB, UniProtKB, PubMed, PubMed]; Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex., [RefSeq, PubMed]; Our results demonstrated a novel role of SCO1 in modulating insulin sensitivity via the regulation of copper concentration in WAT and suggested a potential therapeutic target for T2DM., [RefSeq, PubMed]; Results describe the tissue distribution of SCO1 and SCO2 in mouse and human tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTD6", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0030016 myofibril", "go_biological_process": "GO:0001889 liver development;GO:0006878 intracellular copper ion homeostasis;GO:0006955 immune response;GO:0072659 protein localization to plasma membrane;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5SUC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SYL1-1", "uniprot_id": "KS6R_MOUSE", "mass": 31682.0, "length": 278, "protein_name": "Ribosomal protein S6 kinase-related protein", "gene_name": "Rskr", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Rskr", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribosomal protein S6 kinase-related protein; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5SYL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61235-1", "uniprot_id": "SNTB2_MOUSE", "mass": 56382.0, "length": 520, "protein_name": "Beta-2-syntrophin", "gene_name": "Sntb2", "organism": "Mouse", "refseq_name": "beta-2-syntrophin isoform 2", "refseq_ac": "NP_033255", "gene_names_uniprotkb": "Sntb2; Snt2b2", "gene_names_refseq": "SNT3; SNTL; Snt2; Sntb2", "protein_names_uniprotkb": "Beta-2-syntrophin; 59 kDa dystrophin-associated protein A1 basic component 2; SNT3; SNTL; Syntrophin-3; Syntrophin-like", "protein_names_refseq": "59 kDa dystrophin-associated protein A1 basic component 2; beta-2-syntrophin isoform 2; beta-2-syntrophin; syntrophin-3", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:20650); (R-MMU-9913351)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10404183;10893187;17114649;17242355;19131326;19144319;21183079;25625330;28528544;30990585;31219806;7592771;7691103;9214383;9412493", "class_list": "", "function": "Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN (By similarity)., [UniProtKB]; Current study shows that high SNTB2 in obese adipose tissues restricts adipocyte growth and thereby may contribute to metabolic diseases., [RefSeq, PubMed]; Suggest alpha/beta2-syntrophins do not regulate ABCA1 activity and insulin release but may have a role in regulating glucose uptake, ERK and SR-BI levels, and sphingomyelin metabolism in obesity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q61235-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6QIY3-1", "uniprot_id": "SCNAA_MOUSE", "mass": 220552.0, "length": 1958, "protein_name": "Sodium channel protein type 10 subunit alpha", "gene_name": "Scn10a", "organism": "Mouse", "refseq_name": "sodium channel protein type 10 subunit alpha isoform 2", "refseq_ac": "NP_033160", "gene_names_uniprotkb": "Scn10a; Sns", "gene_names_refseq": "Nav1.8; PN3; SNS; Scn10a", "protein_names_uniprotkb": "Sodium channel protein type 10 subunit alpha; PN3; Peripheral nerve sodium channel 3; Sensory neuron sodium channel; Sodium channel protein type X subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.8", "protein_names_refseq": "peripheral nerve sodium channel 3; sensory neuron sodium channel; sodium channel protein type 10 subunit alpha isoform 2; sodium channel protein type 10 subunit alpha; sodium channel protein type X subunit alpha; voltage gated sodium channel; voltage-gated sodium channel subunit alpha Nav1.8", "tax_id": 10090, "disease": "generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); familial episodic pain syndrome 2 (Disease Ontology:DOID:0111730); sciatic neuropathy (Disease Ontology:DOID:11446); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:20264)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15047701;15123669;21750661;22426212;24159039;25428506", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB]; Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q62243;Q6EWG7;Q6KCH7;Q703F9", "ec_number_list": "1.8.-.-", "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential;GO:0005248 voltage-gated sodium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0042734 presynaptic membrane;GO:0044299 C-fiber", "go_biological_process": "GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0050965 detection of temperature stimulus involved in sensory perception of pain;GO:0086010 membrane depolarization during action potential;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6QIY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGW5-1", "uniprot_id": "SOSB2_MOUSE", "mass": 21749.0, "length": 198, "protein_name": "SOSS complex subunit B2", "gene_name": "Nabp1", "organism": "Mouse", "refseq_name": "SOSS complex subunit B2 isoform b", "refseq_ac": "NP_001297477", "gene_names_uniprotkb": "Nabp1; Obfc2a; Ssb2", "gene_names_refseq": "4930434H03Rik; 4930442A21Rik; 4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nabp1; Nbp1; Obfc2a; Ssb2", "protein_names_uniprotkb": "SOSS complex subunit B2; Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; SOSS-B2; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; Single-stranded DNA-binding protein 2", "protein_names_refseq": "SOSS complex subunit B2 isoform b; SOSS complex subunit B2; SOSS-B2; oligonucleotide/oligosaccharide-binding fold containing 2A; oligonucleotide/oligosaccharide-binding fold-containing protein 2A; sensor of single-strand DNA complex subunit B2; sensor of ssDNA subunit B2; single-stranded DNA-binding protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:109019); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16533169;25917330;30084848", "class_list": "", "function": "Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity)., [UniProtKB, PubMed]; NABP1 binds single-stranded nucleic acids, but not double-stranded DNA, suggesting that it functions as a single-stranded nucleic acid binding protein, [RefSeq, PubMed]; Ssb1 is likely able to compensate for the loss of Ssb2 in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C154;Q8C164", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination;GO:0044818 mitotic G2/M transition checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BGW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BI17-1", "uniprot_id": "SH2D7_MOUSE", "mass": 50552.0, "length": 458, "protein_name": "SH2 domain-containing protein 7", "gene_name": "Sh2d7", "organism": "Mouse", "refseq_name": "SH2 domain-containing protein 7", "refseq_ac": "NP_776139", "gene_names_uniprotkb": "Sh2d7", "gene_names_refseq": "4933412E14Rik; Sh2d7", "protein_names_uniprotkb": "SH2 domain-containing protein 7", "protein_names_refseq": "SH2 domain-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:244885)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BI17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMC3-1", "uniprot_id": "SHC2_MOUSE", "mass": 61771.0, "length": 573, "protein_name": "SHC-transforming protein 2", "gene_name": "Shc2", "organism": "Mouse", "refseq_name": "SHC-transforming protein 2", "refseq_ac": "NP_001019710", "gene_names_uniprotkb": "Shc2; Sck; ShcB", "gene_names_refseq": "6720466E06; SCK; Shc2; ShcB; Sli", "protein_names_uniprotkb": "SHC-transforming protein 2; Protein Sck; Protein Sli; SH2 domain protein C2; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2", "protein_names_refseq": "SH2 domain protein C2; SHC-transforming protein 2; SHC-transforming protein B; protein Sck; protein Sli; src homology 2 domain-containing-transforming protein C2", "tax_id": 10090, "disease": "", "pathway": " (mmu:216148); (R-MMU-167044); (R-MMU-4420097); (R-MMU-5673001)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12006576;32879382;40885482", "class_list": "", "function": "Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells. Publication Status: Online-Only, [RefSeq, PubMed]; Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BMC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BQU3-1", "uniprot_id": "SDHF3_MOUSE", "mass": 14468.0, "length": 125, "protein_name": "Succinate dehydrogenase assembly factor 3, mitochondrial", "gene_name": "Sdhaf3", "organism": "Mouse", "refseq_name": "succinate dehydrogenase assembly factor 3, mitochondrial isoform b precursor", "refseq_ac": "NP_001071181", "gene_names_uniprotkb": "Sdhaf3; Acn9", "gene_names_refseq": "0610005M07Rik; 4933430A16Rik; Acn9; Sdhaf3", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 3, mitochondrial; SDH assembly factor 3; SDHAF3", "protein_names_refseq": "SDH assembly factor 3; protein ACN9 homolog, mitochondrial; succinate dehydrogenase assembly factor 3, mitochondrial isoform b precursor; succinate dehydrogenase assembly factor 3, mitochondrial", "tax_id": 10090, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537)", "pathway": " (mmu:71238); (R-MMU-9854311)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "35820727", "class_list": "", "function": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BT21", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0034553 mitochondrial respiratory chain complex II assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BQU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BTK5-1", "uniprot_id": "SMYD4_MOUSE", "mass": 88538.0, "length": 799, "protein_name": "Protein-lysine N-methyltransferase SMYD4", "gene_name": "Smyd4", "organism": "Mouse", "refseq_name": "protein-lysine N-methyltransferase SMYD4", "refseq_ac": "NP_001096081", "gene_names_uniprotkb": "Smyd4; Kiaa1936", "gene_names_refseq": "G430029E23Rik; Smyd4", "protein_names_uniprotkb": "Protein-lysine N-methyltransferase SMYD4; 2.1.1.-; SET and MYND domain-containing protein 4", "protein_names_refseq": "SET and MYND domain-containing protein 4; protein-lysine N-methyltransferase SMYD4", "tax_id": 10090, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:319822)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "28498369;30110327;31219806;34428180", "class_list": "", "function": "MFACR (mitochondrial fission and apoptosis-related circRNA) is derived from the splicing of exon 5 of Smyd4 gene. MFACR is crucial in regulating mitochondrial dynamics and apoptosis in the heart. MFACR mediates cardiomyocyte apoptosis and myocardial infarction by targeting miR-652-3p-dependent MTP18 activation and consequent mitochondrial fission., [RefSeq, PubMed]; Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity (By similarity). May also act as a histone methyltransferase (By similarity). Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2BDD0;Q3U3Z8;Q501N5;Q5SWN4;Q69Z60;Q8BMP3", "ec_number_list": "2.1.1.-;2.1.1.359;2.1.1.364;2.1.1.361;2.1.1.354;2.1.1.355;2.1.1.362", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007507 heart development;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BTK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BX32-1", "uniprot_id": "SLX1_MOUSE", "mass": 30656.0, "length": 270, "protein_name": "Structure-specific endonuclease subunit SLX1", "gene_name": "Slx1b", "organism": "Mouse", "refseq_name": "structure-specific endonuclease subunit SLX1", "refseq_ac": "NP_083696", "gene_names_uniprotkb": "Slx1b; Giyd1; Giyd2; Slx1", "gene_names_refseq": "1110030E23Rik; 2410170E21Rik; 4833422P03Rik; Giyd1; Giyd2; Slx1b", "protein_names_uniprotkb": "Structure-specific endonuclease subunit SLX1; 3.1.-.-; GIY-YIG domain-containing protein 1", "protein_names_refseq": "GIY-YIG domain containing 2; GIY-YIG domain-containing protein 1; structure-specific endonuclease subunit SLX1", "tax_id": 10090, "disease": "Fanconi-like syndrome (Disease Ontology:DOID:0090066)", "pathway": " (mmu:75764); (R-MMU-5693568); (R-MMU-6783310)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;24076219;27010503", "class_list": "", "function": "Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products., [UniProtKB, HAMAP]; Data indicate that SLX1 and MUS81-EME1 nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D609", "ec_number_list": "5.6.2.1;2.3.2.27;5.6.2.4;3.6.-.-;3.6.4.-;5.6.2.3;3.1.-.-;2.7.11.1;3.1.21.-;3.1.4.1;3.6.4.13;3.4.19.12;3.5.2.6;2.3.1.48;2.3.1.-;3.1.22.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008821 crossover junction DNA endonuclease activity;GO:0017108 5'-flap endonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000228 nuclear chromosome;GO:0033557 Slx1-Slx4 complex", "go_biological_process": "GO:1904431 positive regulation of t-circle formation;GO:0000724 double-strand break repair via homologous recombination;GO:0090656 t-circle formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BX32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYY9-1", "uniprot_id": "SPA3B_MOUSE", "mass": 47415.0, "length": 420, "protein_name": "Serine protease inhibitor A3B", "gene_name": "Serpina3b", "organism": "Mouse", "refseq_name": "serine protease inhibitor A3B precursor", "refseq_ac": "NP_766612", "gene_names_uniprotkb": "Serpina3b", "gene_names_refseq": "6A1; A030003A19Rik; Serpina3b", "protein_names_uniprotkb": "Serine protease inhibitor A3B; Serpin A3B", "protein_names_refseq": "alpha-1 antiproteinase; antitrypsin; serine (or cysteine) proteinase inhibitor, clade A, member 3B; serine protease inhibitor A3B precursor; serine protease inhibitor A3B; serpin A3B", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); cystic fibrosis (Disease Ontology:DOID:1485); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); vasculitis (Disease Ontology:DOID:865)", "pathway": " (mmu:271047)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12659817;15638460;34428180", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0034097 response to cytokine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BYY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0N0-1", "uniprot_id": "SMKZ_MOUSE", "mass": 56083.0, "length": 497, "protein_name": "Sperm motility kinase Z", "gene_name": "Gm4922", "organism": "Mouse", "refseq_name": "sperm motility kinase Z", "refseq_ac": "NP_808374", "gene_names_uniprotkb": "Gm4922", "gene_names_refseq": "4933423E17; EG237300; Gm4922", "protein_names_uniprotkb": "Sperm motility kinase Z; 2.7.11.1", "protein_names_refseq": "sperm motility kinase Z", "tax_id": 10090, "disease": "", "pathway": " (mmu:237300)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15289607;29187734;30084848", "class_list": "", "function": "First described as a mouse-specific duplication of the MARK kinase family, and named as MarkmA1., [RefSeq, PubMed]; May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C0N0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C0X8-1", "uniprot_id": "SMKX_MOUSE", "mass": 71931.0, "length": 640, "protein_name": "Sperm motility kinase X", "gene_name": "", "organism": "Mouse", "refseq_name": "sperm motility kinase X", "refseq_ac": "NP_941057", "gene_names_uniprotkb": "", "gene_names_refseq": "4921509C19Rik; Gm1005", "protein_names_uniprotkb": "Sperm motility kinase X; 2.7.11.1", "protein_names_refseq": "MarkmE1; sperm motility kinase X", "tax_id": 10090, "disease": "", "pathway": " (mmu:381393)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15289607", "class_list": "", "function": "First described as a mouse-specific duplication of the MARK kinase family, and named MarkmE1, [RefSeq, PubMed]; May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0042149 cellular response to glucose starvation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C0X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K078-1", "uniprot_id": "SO4A1_MOUSE", "mass": 77669.0, "length": 723, "protein_name": "Solute carrier organic anion transporter family member 4A1", "gene_name": "Slco4a1", "organism": "Mouse", "refseq_name": "solute carrier organic anion transporter family member 4A1", "refseq_ac": "NP_683735", "gene_names_uniprotkb": "Slco4a1; Oatp4a1; Oatpe; Slc21a12", "gene_names_refseq": "OATP-E; Slc21a12; Slco4a1", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 4A1; OATP-E; Organic anion-transporting polypeptide E; Sodium-independent organic anion transporter E; Solute carrier family 21 member 12", "protein_names_refseq": "organic anion-transporting polypeptide E; sodium-independent organic anion transporter E; solute carrier family 21 (organic anion transporter), member 12; solute carrier family 21 member 12; solute carrier organic anion transporter family member 4A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:108115); (R-MMU-879518)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;19144319;25428506;25605945;35331000;36210013", "class_list": "", "function": "Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (By similarity). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (By similarity). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable)., [UniProtKB, UniProtKB]; Solute carrier organic anion transporter family member 4A1 promotes colorectal cancer progression and is regulated by miR-1224-5p., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZT4", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015349 thyroid hormone transmembrane transporter activity;GO:0015132 prostaglandin transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015711 organic anion transport;GO:0043252 sodium-independent organic anion transport;GO:0042403 thyroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K078-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K194-1", "uniprot_id": "SNR27_MOUSE", "mass": 18885.0, "length": 155, "protein_name": "U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein", "gene_name": "Snrnp27", "organism": "Mouse", "refseq_name": "U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein", "refseq_ac": "NP_079941", "gene_names_uniprotkb": "Snrnp27", "gene_names_refseq": "2610209M04Rik; Ry1; Snrnp27", "protein_names_uniprotkb": "U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein; U4/U6.U5 snRNP 27 kDa protein; U4/U6.U5 tri-snRNP-associated protein 3; U4/U6.U5-27K", "protein_names_refseq": "U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein; U4/U6.U5 snRNP 27 kDa protein; U4/U6.U5 tri-snRNP-associated protein 3; U4/U6.U5-27K; putative nucleic acid binding protein RY-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66618); (R-MMU-72163)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25428506;34428180", "class_list": "", "function": "May play a role in mRNA splicing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRA8;Q9CSV0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K194-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3V1-1", "uniprot_id": "SPAT4_MOUSE", "mass": 33579.0, "length": 295, "protein_name": "Spermatogenesis-associated protein 4", "gene_name": "Spata4", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 4", "refseq_ac": "NP_598472", "gene_names_uniprotkb": "Spata4; Srg2; Tsarg2", "gene_names_refseq": "1700001N01Rik; Spata4; Srg2; TSARG2", "protein_names_uniprotkb": "Spermatogenesis-associated protein 4; Spermatogenesis-related gene 2 protein; Testis and spermatogenesis cell-related protein 2; Testis spermatocyte apoptosis-related gene 2 protein", "protein_names_refseq": "spermatogenesis-associated protein 4; spermatogenesis-related gene 2 protein; testis and spermatogenesis cell-related protein 2; testis spermatocyte apoptosis-related gene 2 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69281)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12417927;14669511;16336790;21445983;24146794;39853433", "class_list": "", "function": "Analysis of SPATA4 expression and variation in promotor sequences, [RefSeq, PubMed]; May play a role in apoptosis regulation., [UniProtKB, UniProtKB]; RFX1 may have negative effect on cell proliferation of Sertoli cells via modulating Spata4 expression levels by binding the conserved 14-bp cis-elements of Spata4 promoter. Publication Status: Online-Only, [RefSeq, PubMed]; RT-PCR showed that SRG2 was expressed significantly in testis., [RefSeq, PubMed]; Spata4 promotes osteoblast differentiation and mineralization through the Erk-activated Runx2 pathway., [RefSeq, PubMed]; Srg2 gene was found up-regulated distinctly and playing an important role in cryptorchid testis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q923U8", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005930 axoneme", "go_biological_process": "GO:0051493 regulation of cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K3V1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TN29-1", "uniprot_id": "SMAP2_MOUSE", "mass": 46578.0, "length": 428, "protein_name": "Stromal membrane-associated protein 2", "gene_name": "Smap2", "organism": "Mouse", "refseq_name": "stromal membrane-associated protein 2", "refseq_ac": "NP_598477", "gene_names_uniprotkb": "Smap2; Smap1l", "gene_names_refseq": "1810031K02Rik; Smap1l; Smap2", "protein_names_uniprotkb": "Stromal membrane-associated protein 2; Stromal membrane-associated protein 1-like", "protein_names_refseq": "stromal membrane-associated GTPase-activating protein 2; stromal membrane-associated protein 2", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:69780)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "15345747;16571680;17242355;19144319;21183079;21368446;22517741;22645316;23864717;26296315;26495903;31219806;34428180;36210013;36852467;40021952;40885482", "class_list": "", "function": "Either SMAP1 or SMAP2, is required for proper embryogenesis, [RefSeq, PubMed]; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network., [UniProtKB, PubMed]; Study reveals a link between SMAP2 and CALM/syntaxin2 in clathrin-coated vesicle formation from the trans-Golgi network and subsequent acrosome formation, [RefSeq, PubMed]; The trans-Golgi network (TGN) was verified as an additional site of SMAP2 localization based on its co-localization with various TGN-marker proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U798", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q7TN29-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQP2-1", "uniprot_id": "TPPC2_MOUSE", "mass": 16441.0, "length": 140, "protein_name": "Trafficking protein particle complex subunit 2", "gene_name": "Trappc2", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 2 isoform 2", "refseq_ac": "NP_001300651", "gene_names_uniprotkb": "Trappc2; Sedl", "gene_names_refseq": "1110066L09Rik; 1810064C02Rik; MIP-2A; Sedl; TRS20; Trappc2", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 2; Sedlin", "protein_names_refseq": "sedlin; spondyloepiphyseal dysplasia tarda protein; spondyloepiphyseal dysplasia, late; trafficking protein particle complex subunit 2 isoform 2; trafficking protein particle complex subunit 2", "tax_id": 10090, "disease": "X-linked spondyloepiphyseal dysplasia tarda (Disease Ontology:DOID:0080362); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789)", "pathway": " (mmu:66050); (mmu:66226); (R-MMU-204005); (R-MMU-8876198)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "12361953;19650763;21750661;31219806", "class_list": "", "function": "Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity)., [UniProtKB]; The sedlin mutations S73L, F83S and V130D cause SEDT by sedlin misfolding, whereas the D47Y mutation may influence normal TRAPP (transport protein particle) dynamics. Publication Status: Online-Only, [RefSeq, PubMed]; X-ray crystallography analysis of mouse SEDL, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BP61;Q9CQF5;Q9D0V3;Q9DCM3", "ec_number_list": "", "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0001501 skeletal system development;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99NC0-1", "uniprot_id": "VGLL1_MOUSE", "mass": 34691.0, "length": 307, "protein_name": "Transcription cofactor vestigial-like protein 1", "gene_name": "Vgll1", "organism": "Mouse", "refseq_name": "transcription cofactor vestigial-like protein 1", "refseq_ac": "NP_001300692", "gene_names_uniprotkb": "Vgll1", "gene_names_refseq": "Tondu; Vgll1", "protein_names_uniprotkb": "Transcription cofactor vestigial-like protein 1; Vestigial-related factor; Vgl-1", "protein_names_refseq": "transcription cofactor vestigial-like protein 1; vestigial like 1 homolog; vestigial-related factor; vgl-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:170828)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;22632831;35820727", "class_list": "", "function": "May act as a specific coactivator for the mammalian TEFs., [UniProtKB]; Vgll1 interacts with TEAD4 in a manner similar to the transcription coactivators, as well as oncogenes YAP and TAZ, despite having a varied primary sequence. Vgll1 has the potential to promote cancer progression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AFJ9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99NC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61069-1", "uniprot_id": "USF1_MOUSE", "mass": 33570.0, "length": 310, "protein_name": "Upstream stimulatory factor 1", "gene_name": "Usf1", "organism": "Mouse", "refseq_name": "upstream stimulatory factor 1 isoform 1", "refseq_ac": "NP_001292605", "gene_names_uniprotkb": "Usf1; Usf", "gene_names_refseq": "Usf1; bHLHb11", "protein_names_uniprotkb": "Upstream stimulatory factor 1; Major late transcription factor 1", "protein_names_refseq": "Upstream stimulatory factor 1 (Major late transcription factor 1); major late transcription factor 1; upstream stimulatory factor 1 isoform 1", "tax_id": 10090, "disease": "cardiovascular system disease (Disease Ontology:DOID:1287); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:22278); (R-MMU-9018519); (R-MMU-9824585)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21750661;25428506;30084848;34385562;34428180;35820727;40997131;8938446", "class_list": "", "function": "Hematopoietic upstream stimulating factor 1 deficiency is associated with increased atherosclerosis susceptibility in LDL receptor knockout mice. Publication Status: Online-Only, [RefSeq, PubMed]; This protein encoded by this gene is a member of the basic-Helix-Hoop-Helix-Leucine zipper (bHLH-LZ) family and encodes a protein that can act as a transcription factor. Studies indicate that the basic region interacts with DNA at E-Box motifs, while the helix-loop-helix and leucine zipper domains are involved in dimerization with different partners. This protein is involved in a wide array of biological pathways, including cell cycle regulation, immune response, and responses to ultraviolet radiation. Mice lacking most of the coding exons of this gene often lacked both whiskers and nasal fur, and were prone to epileptic seizures, while mice lacking both this gene and another family member, Usf2, displayed embryonic lethality (PMID:9520440). Mutations in the human ortholog of this gene have been associated with Familial Combined Hyperlipidemia (FCHL) in humans. Pseudogenes of this gene are found on chromosome 11 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]., [RefSeq]; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0019086 late viral transcription;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032869 cellular response to insulin stimulus;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61069-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70284-1", "uniprot_id": "TGIF1_MOUSE", "mass": 29573.0, "length": 272, "protein_name": "Homeobox protein TGIF1", "gene_name": "Tgif1", "organism": "Mouse", "refseq_name": "homeobox protein TGIF1 isoform c", "refseq_ac": "NP_001157546", "gene_names_uniprotkb": "Tgif1; Tgif", "gene_names_refseq": "Tgif1; Tgif", "protein_names_uniprotkb": "Homeobox protein TGIF1; 5'-TG-3'-interacting factor 1", "protein_names_refseq": "5'-TG-3'-interacting factor 1; TALE family homeobox; TG interacting factor 1; homeobox protein TGIF1 isoform c; homeobox protein TGIF1", "tax_id": 10090, "disease": "holoprosencephaly 4 (Disease Ontology:DOID:0110880); otitis media (Disease Ontology:DOID:10754); holoprosencephaly (Disease Ontology:DOID:4621); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (mmu:21815); (R-MMU-2173795)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;38492636;38575107;38661167;8901052", "class_list": "", "function": "Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities (By similarity)., [UniProtKB]; MircoRNA-25-3p in skin precursor cell-induced Schwann cell-derived extracellular vesicles promotes axon regeneration by targeting Tgif1., [RefSeq, PubMed]; TG-interacting factor 1 regulates mitotic clonal expansion during adipocyte differentiation., [RefSeq, PubMed]; Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q921F9;Q99JS3", "ec_number_list": "", "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0003682 chromatin binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0010470 regulation of gastrulation;GO:1902871 positive regulation of amacrine cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P70284-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JLC4-1", "uniprot_id": "SORC1_MOUSE", "mass": 129631.0, "length": 1167, "protein_name": "VPS10 domain-containing receptor SorCS1", "gene_name": "Sorcs1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sorcs1; Sorcs", "gene_names_refseq": "", "protein_names_uniprotkb": "VPS10 domain-containing receptor SorCS1; mSorCS", "protein_names_refseq": "", "tax_id": 10090, "disease": "proteinuria (Disease Ontology:DOID:576)", "pathway": " (mmu:58178)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10600506;10760602;20485683;21750661;30899004;33300544", "class_list": "", "function": "", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q8VI45;Q922I1;Q9QY21", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006892 post-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9JLC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UUJ4-1", "uniprot_id": "STRAA_MOUSE", "mass": 48236.0, "length": 431, "protein_name": "STE20-related kinase adapter protein alpha", "gene_name": "Strada", "organism": "Mouse", "refseq_name": "STE20-related kinase adapter protein alpha isoform 1", "refseq_ac": "NP_001239377", "gene_names_uniprotkb": "Strada; Lyk5; Strad", "gene_names_refseq": "2610019A05Rik; 6030402H20Rik; E130112C09Rik; Strada", "protein_names_uniprotkb": "STE20-related kinase adapter protein alpha; STE20-related adapter protein; STRAD alpha", "protein_names_refseq": "STE20-related adapter protein; STE20-related kinase adapter protein alpha isoform 1; STE20-related kinase adapter protein alpha; STRAD alpha; protein kinase LYK5", "tax_id": 10090, "disease": "polyhydramnios, megalencephaly, and symptomatic epilepsy (Disease Ontology:DOID:0070511); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:72149); (R-MMU-380972)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;20424326;21750661;21903876;25428506;25605945;30084848;31219806;34428180", "class_list": "", "function": "Aberrant nuclear accumulation of LKB1 caused by STRADalpha deficiency contributes to hyperactivation of mTORC1 signaling and disruption of neuronal lamination during corticogenesis, [RefSeq, PubMed]; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Quantitative PCR revealed significantly reduced LKB1, MO25alpha, and STRADbeta mRNA in LKB1(-/-) muscle. These findings demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK in skeletal muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6VEU7;Q9D0G8", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0030295 protein kinase activator activity;GO:0019900 kinase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032147 activation of protein kinase activity;GO:0006611 protein export from nucleus;GO:0070314 G1 to G0 transition", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3UUJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHN8-1", "uniprot_id": "WHR1_MOUSE", "mass": 28104.0, "length": 254, "protein_name": "Winged helix repair factor 1", "gene_name": "Stk19; Whr1", "organism": "Mouse", "refseq_name": "winged helix repair factor 1", "refseq_ac": "NP_062315", "gene_names_uniprotkb": "Stk19; Whr1; Rp1; Stk19; Twh19", "gene_names_refseq": "G11; RP1; Stk19; Whr1", "protein_names_uniprotkb": "Winged helix repair factor 1; Inactive serine/threonine-protein kinase 19; Protein RP1; Tandem winged helix protein formerly known as STK19", "protein_names_refseq": "inactive serine/threonine-protein kinase 19; serine/threonine kinase 19; serine/threonine-protein kinase 19; tandem winged helix protein formerly known as STK19; winged helix repair factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:54402)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14656967;21750661;31219806", "class_list": "", "function": "DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER). Acts as part of a TC-NER complex which assembles and interacts with RNA polymerase II (RNAPII) when it stalls at DNA lesions. TC-NER complex subunit UVSSA binds to the GTF2H1/p62 subunit of the TFIIH transcription factor complex, tethering TFIIH to the TC-NER complex. WHR1/STK19 then interacts with the XPD helicase subunit of TFIIH which guides TFIIH to DNA downstream of the stalled RNAPII, ensuring DNA repair. Directly interacts with RNAPII and also binds to downstream DNA. Promotes the timely removal of DNA damage-stalled RNAPII, allowing downstream NER factors to access DNA lesions. Required for monoubiquitination of UVSSA. Regulates repositioning and stabilization of UVSSA within the TC-NER complex. Stimulates ubiquitination of RNAPII complex member RBP1. Also binds to RNA and regulates the expression levels of many mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70347", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003690 double-stranded DNA binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0006281 DNA repair;GO:1903518 positive regulation of single strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JHN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4P7-1", "uniprot_id": "ST7L_MOUSE", "mass": 63368.0, "length": 559, "protein_name": "Suppressor of tumorigenicity 7 protein-like", "gene_name": "St7l", "organism": "Mouse", "refseq_name": "suppressor of tumorigenicity 7 protein-like isoform 2", "refseq_ac": "NP_001240631", "gene_names_uniprotkb": "St7l; St7r", "gene_names_refseq": "St7l; St7r", "protein_names_uniprotkb": "Suppressor of tumorigenicity 7 protein-like; ST7-related protein", "protein_names_refseq": "ST7-related protein; suppressor of tumorigenicity 7 protein-like isoform 2; suppressor of tumorigenicity 7 protein-like; tumor suppressor ST7 like", "tax_id": 10090, "disease": "", "pathway": " (mmu:229681)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12060862;21750661;25428506;25428507;30084848;30779550", "class_list": "", "function": "The first report on molecular cloning and initial characterization of mouse St7r, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9Y2;Q3UNR1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K4P7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYY8-1", "uniprot_id": "SPAST_MOUSE", "mass": 66456.0, "length": 614, "protein_name": "Spastin", "gene_name": "Spast", "organism": "Mouse", "refseq_name": "spastin isoform 1", "refseq_ac": "NP_001156342", "gene_names_uniprotkb": "Spast; Kiaa1083; SPAST; SPG4; Spg4", "gene_names_refseq": "Spast; Spg4; mKIAA1083", "protein_names_uniprotkb": "Spastin; 5.6.1.1", "protein_names_refseq": "spastic paraplegia 4 homolog; spastin isoform 1", "tax_id": 10090, "disease": "hereditary spastic paraplegia 4 (Disease Ontology:DOID:0110792); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (mmu:50850); (R-MMU-9668328)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10610178;15345747;16026783;17101632;18234839;18495362;19141076;19453301;20530212;21750661;22773755;25428506;31219806;38047349;38231910", "class_list": "", "function": "14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist intervention. Publication Status: Online-Only, [RefSeq, PubMed]; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches., [UniProtKB, HAMAP, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; CRMP5 participates in oocyte meiosis by regulating spastin to correct microtubule-kinetochore misconnection., [RefSeq, PubMed]; Involved in lipid metabolism by regulating the size and distribution of lipid droplets., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9768, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPY6;Q80VE0;Q9CVK0", "ec_number_list": "3.6.5.-;3.6.4.6;5.6.1.1", "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0051013 microtubule severing;GO:0031117 positive regulation of microtubule depolymerization;GO:0051260 protein homooligomerization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9QYY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BL74-1", "uniprot_id": "TF3C2_MOUSE", "mass": 100275.0, "length": 907, "protein_name": "General transcription factor 3C polypeptide 2", "gene_name": "Gtf3c2", "organism": "Mouse", "refseq_name": "general transcription factor 3C polypeptide 2", "refseq_ac": "NP_082177", "gene_names_uniprotkb": "Gtf3c2; Kiaa0011", "gene_names_refseq": "1300004C11Rik; 2610510G03Rik; Gtf3c2; TFIIIC110; mKIAA0011", "protein_names_uniprotkb": "General transcription factor 3C polypeptide 2; TF3C-beta; TFIIIC 110 kDa subunit; TFIIIC110; Transcription factor IIIC 110 kDa subunit; Transcription factor IIIC subunit beta", "protein_names_refseq": "TF3C-beta; TFIIIC 110 kDa subunit; TFIIIC-BETA; general transcription factor 3C polypeptide 2; transcription factor IIIC 110 kDa subunit; transcription factor IIIC subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:71752); (R-MMU-76061); (R-MMU-76066)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7Z9;Q80XQ7;Q8BJJ4;Q8BLP3;Q8K1J1;Q9CSS0;Q9CVE6;Q9DBK6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000995 RNA polymerase III general transcription initiation factor activity", "go_cellular_component": "GO:0000127 transcription factor TFIIIC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006383 transcription by RNA polymerase III;GO:0006384 transcription initiation at RNA polymerase III promoter;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BL74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JV5-1", "uniprot_id": "STAR4_MOUSE", "mass": 25579.0, "length": 224, "protein_name": "StAR-related lipid transfer protein 4", "gene_name": "Stard4", "organism": "Mouse", "refseq_name": "stAR-related lipid transfer protein 4 isoform 1", "refseq_ac": "NP_598535", "gene_names_uniprotkb": "Stard4", "gene_names_refseq": "4632419C16Rik; 9030213J02Rik; Stard4", "protein_names_uniprotkb": "StAR-related lipid transfer protein 4; START domain-containing protein 4; StARD4", "protein_names_refseq": "START domain-containing protein 4; StAR-related lipid transfer (START) domain containing 4; StAR-related lipid transfer protein 4; stAR-related lipid transfer protein 4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:170459); (R-MMU-196108)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12011452;12011453;15760897;18403318;19965609;21750661;26168008;31219806;34428180", "class_list": "", "function": "A model of STARD4 membrane interaction and sterol binding and release that requires dynamic movement of both the Omega1 loop and membrane insertion of the C-terminal alpha-helix., [RefSeq, PubMed]; Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols., [UniProtKB, UniProtKB]; StARD4's role can largely be compensated for by other intracellular cholesterol transporters. Erratum:[J Lipid Res. 2010 Jun;51(6):1618], [RefSeq, PubMed]; StarD4 is regulated by sterols via SREBP-2, and StarD5 is activated by ER stress cholesterol metabolism; they serve different functions, [RefSeq, PubMed]; StarD4 plays an important role as a directional cholesterol transporter in the maintenance of cellular cholesterol homeostasis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0070859 positive regulation of bile acid biosynthetic process;GO:0032367 intracellular cholesterol transport;GO:0070508 cholesterol import;GO:0090205 positive regulation of cholesterol metabolic process;GO:0010879 cholesterol transport involved in cholesterol storage", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99JV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14BK3-1", "uniprot_id": "TEX35_MOUSE", "mass": 24056.0, "length": 207, "protein_name": "Testis-expressed protein 35", "gene_name": "Tex35", "organism": "Mouse", "refseq_name": "testis-expressed protein 35 isoform 2", "refseq_ac": "NP_001291988", "gene_names_uniprotkb": "Tex35; 1700057K13Rik; Tsc24", "gene_names_refseq": "1700057K13Rik; Tex35", "protein_names_uniprotkb": "Testis-expressed protein 35; Testis-specific conserved protein of 24 kDa", "protein_names_refseq": "testis-expressed protein 35 isoform 2; testis-expressed protein 35; testis-expressed sequence 35 protein; testis-specific conserved protein of 24 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:73435)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17077512;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KKY9;Q9D9J9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0015630 microtubule cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q14BK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70491-1", "uniprot_id": "STRA6_MOUSE", "mass": 73775.0, "length": 670, "protein_name": "Receptor for retinol uptake STRA6", "gene_name": "Stra6", "organism": "Mouse", "refseq_name": "receptor for retinol uptake STRA6", "refseq_ac": "NP_001155947", "gene_names_uniprotkb": "Stra6", "gene_names_refseq": "Stra6", "protein_names_uniprotkb": "Receptor for retinol uptake STRA6; Retinoic acid-responsive protein; Retinol-binding protein receptor STRA6; Stimulated by retinoic acid gene 6 protein", "protein_names_refseq": "receptor for retinol uptake STRA6; retinoic acid-responsive protein; retinol-binding protein receptor STRA6; stimulated by retinoic acid gene 6 protein", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); syndromic microphthalmia 9 (Disease Ontology:DOID:0111807); exfoliation syndrome (Disease Ontology:DOID:13641)", "pathway": " (mmu:20897); (R-MMU-2453902)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10727869;11358845;11832495;21368206;21750661;22467576;23839944;24852372;31219806;34428180;36592123;38395306;39269368;7644503;8792610;9203140", "class_list": "", "function": "Functions as a retinol transporter (PubMed:23839944, PubMed:24852372). Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (By similarity). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:23839944). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid and 11-cis-retinal (PubMed:22467576, PubMed:24852372). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (PubMed:22467576, PubMed:23839944, PubMed:24852372). Does not transport retinoic acid (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice., [RefSeq, PubMed]; The Effects of STRA6 Regulation of the Circadian Rhythm on Choroidal Neovascularization., [RefSeq, PubMed]; Unraveling the mystery of ocular retinoid turnover: Insights from albino mice and the role of STRA6., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6DIA8", "ec_number_list": "", "go_molecular_function": "GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0034632 retinol transmembrane transporter activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060323 head morphogenesis;GO:0030540 female genitalia development;GO:0043585 nose morphogenesis;GO:0048520 positive regulation of behavior;GO:0060900 embryonic camera-type eye formation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O70491-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYM8-1", "uniprot_id": "SYCM_MOUSE", "mass": 61272.0, "length": 551, "protein_name": "Probable cysteine--tRNA ligase, mitochondrial", "gene_name": "Cars2", "organism": "Mouse", "refseq_name": "probable cysteine--tRNA ligase, mitochondrial isoform 2", "refseq_ac": "NP_077210", "gene_names_uniprotkb": "Cars2", "gene_names_refseq": "2310051N18Rik; 2410044A07Rik; Cars2; D530030H10Rik; cysRS", "protein_names_uniprotkb": "Probable cysteine--tRNA ligase, mitochondrial; 6.1.1.16; CysRS; Cysteinyl-tRNA synthetase", "protein_names_refseq": "cysteinyl-tRNA synthetase 2 (mitochondrial)(putative); probable cysteine--tRNA ligase, mitochondrial isoform 2; probable cysteine--tRNA ligase, mitochondrial; probable cysteinyl-tRNA synthetase, mitochondrial", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 27 (Disease Ontology:DOID:0111489)", "pathway": " (mmu:71941)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;29079736;31219806;34428180;37507081", "class_list": "", "function": "In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides (PubMed:29079736). CysSSHs behave as potent antioxidants and cellular protectants (PubMed:29079736)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6U9", "ec_number_list": "6.1.1.16", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004817 cysteine-tRNA ligase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006423 cysteinyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BYM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99K82-1", "uniprot_id": "SMOX_MOUSE", "mass": 61852.0, "length": 555, "protein_name": "Spermine oxidase", "gene_name": "Smox", "organism": "Mouse", "refseq_name": "spermine oxidase isoform a", "refseq_ac": "NP_001171304", "gene_names_uniprotkb": "Smox; Smo", "gene_names_refseq": "B130066H01Rik; PAOh1; PAO; SMO; Smox", "protein_names_uniprotkb": "Spermine oxidase; 1.5.3.16; PAO-1; PAOh1; Polyamine oxidase 1", "protein_names_refseq": "PAO-1; polyamine oxidase 1; spermine oxidase isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:228608); (R-MMU-141334); (R-MMU-351200)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12141946;12458219;14764092;15955064;21750661;34428180;34767785;37984250;39002816", "class_list": "", "function": "Expression and characterization of mouse spermine oxidase, [RefSeq, PubMed]; Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal., [UniProtKB]; Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke., [RefSeq, PubMed]; Protective Role of Spermidine in Colitis and Colon Carcinogenesis. Erratum:[Gastroenterology. 2022 Jun;162(7):2138-2143. doi: 10.1053/j.gastro.2022.04.006. PMID: 35461802], [RefSeq, PubMed]; Spermine oxidase regulates liver inflammation and fibrosis through beta-catenin pathway., [RefSeq, PubMed]; We identified a second domain that is necessary for nuclear localization of the spermine oxidase splice variant, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANQ8;A2ANQ9;A2ANR0;A2ANR1;A2ANR2;Q70LA3;Q70LA4;Q70LA5;Q70LA7;Q70LA8;Q70LA9;Q70LB0;Q8CJ56;Q8CJ57", "ec_number_list": "1.5.3.16", "go_molecular_function": "GO:0046592 polyamine oxidase activity;GO:0052901 spermine oxidase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006598 polyamine catabolic process;GO:0046208 spermine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99K82-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CGA2-1", "uniprot_id": "TBC14_MOUSE", "mass": 78315.0, "length": 694, "protein_name": "TBC1 domain family member 14", "gene_name": "Tbc1d14", "organism": "Mouse", "refseq_name": "TBC1 domain family member 14 isoform a", "refseq_ac": "NP_001106833", "gene_names_uniprotkb": "Tbc1d14; D5Ertd110e; Kiaa1322", "gene_names_refseq": "2810413P16Rik; D5Ertd110e; Tbc1d14; mKIAA1322", "protein_names_uniprotkb": "TBC1 domain family member 14", "protein_names_refseq": "TBC1 domain family member 14 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:100855); (R-MMU-8854214)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;21750661;31219806;34428180", "class_list": "", "function": "Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2L6;Q4VAC6;Q8CHA5", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0005776 autophagosome", "go_biological_process": "GO:0010507 negative regulation of autophagy;GO:2000785 regulation of autophagosome assembly;GO:0071955 recycling endosome to Golgi transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CGA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPW5-1", "uniprot_id": "SSRB_MOUSE", "mass": 20019.0, "length": 183, "protein_name": "Translocon-associated protein subunit beta", "gene_name": "Ssr2", "organism": "Mouse", "refseq_name": "translocon-associated protein subunit beta isoform 2 precursor", "refseq_ac": "NP_079724", "gene_names_uniprotkb": "Ssr2", "gene_names_refseq": "1500032E05Rik; SSR-beta; Ssr2; TLAP; TRAPB; TRAPbeta", "protein_names_uniprotkb": "Translocon-associated protein subunit beta; SSR-beta; Signal sequence receptor subunit beta; TRAP-beta", "protein_names_refseq": "signal sequence receptor subunit beta; translocon-associated protein subunit beta isoform 2 precursor; translocon-associated protein subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:66256)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;16170054;19349973;21750661;30899004;31219806;34428180", "class_list": "", "function": "TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91Z43;Q9CR94;Q9CX54", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9CPW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C8K7-1", "uniprot_id": "SMIM1_MOUSE", "mass": 8764.0, "length": 78, "protein_name": "Small integral membrane protein 1", "gene_name": "Smim1", "organism": "Mouse", "refseq_name": "small integral membrane protein 1", "refseq_ac": "NP_001157193", "gene_names_uniprotkb": "Smim1", "gene_names_refseq": "0610011H04Rik; 1190007F08Rik; 2700009I11Rik; Smim1", "protein_names_uniprotkb": "Small integral membrane protein 1", "protein_names_refseq": "small integral membrane protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68859)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Regulator of red blood cell formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0048823 nucleate erythrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C8K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YY5-1", "uniprot_id": "SO1A5_MOUSE", "mass": 74663.0, "length": 670, "protein_name": "Solute carrier organic anion transporter family member 1A5", "gene_name": "Slco1a5", "organism": "Mouse", "refseq_name": "solute carrier organic anion transporter family member 1A5", "refseq_ac": "NP_001254636", "gene_names_uniprotkb": "Slco1a5; Oatp1a5; Oatp3; Slc21a7", "gene_names_refseq": "Oatp-3; Oatp3; Slc21a7; Slco1a5", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 1A5; OATP-3; Organic anion-transporting polypeptide 3; Sodium-independent organic anion transporter 3; Solute carrier family 21 member 7", "protein_names_refseq": "organic anion-transporting polypeptide 3; sodium-independent organic anion transporter 3; solute carrier family 21 (organic anion transporter), member 7; solute carrier family 21 member 7; solute carrier organic anion transporter family member 1A5", "tax_id": 10090, "disease": "", "pathway": " (mmu:108096)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11093941;15255953;21084765;21750661", "class_list": "", "function": "Immunoreactivity to anti-Oatp1a antibody was colocalized with PDZK1 in the small intestine of wild-type mice, whereas apical localization of Oatp1a protein was reduced in pdzk1(-/-) mice. PDZK1 appears to act as an adaptor for Oatp1a[Oatp1a], [RefSeq, PubMed]; Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), estrone 3-sulfate and prostaglandin E2, at the plasma membrane. Responsible for intestinal absorption of bile acids. Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) (By similarity). Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (PubMed:15255953). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (By similarity). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q91XS2", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity;GO:0015349 thyroid hormone transmembrane transporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045177 apical part of cell;GO:0031526 brush border membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015721 bile acid and bile salt transport;GO:0050892 intestinal absorption;GO:0015711 organic anion transport;GO:0043252 sodium-independent organic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91YY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIB4-1", "uniprot_id": "TF2H2_MOUSE", "mass": 44687.0, "length": 396, "protein_name": "General transcription factor IIH subunit 2", "gene_name": "Gtf2h2", "organism": "Mouse", "refseq_name": "general transcription factor IIH subunit 2 isoform 1", "refseq_ac": "NP_071294", "gene_names_uniprotkb": "Gtf2h2; Btf2p44", "gene_names_refseq": "44kDa; BTF2 p44; BTF2-p44; Btf2p44; Gtf2h2; p44", "protein_names_uniprotkb": "General transcription factor IIH subunit 2; BTF2 p44; Basic transcription factor 2 44 kDa subunit; General transcription factor IIH polypeptide 2; TFIIH basal transcription factor complex p44 subunit", "protein_names_refseq": "TFIIH basal transcription factor complex p44 subunit; basal transcription factor 2, p44 subunit; basic transcription factor 2 44 kDa subunit; general transcription factor II H, polypeptide 2 (44 kDa subunit); general transcription factor IIH subunit 2 isoform 1; general transcription factor IIH subunit 2; general transcription factor IIH, polypeptide 2 (44 kDa subunit)", "tax_id": 10090, "disease": "", "pathway": " (mmu:23894); (R-MMU-112382); (R-MMU-113418); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-72086); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075)", "pathway_count": 20, "publication_count": 3, "publication_id_list": "10958627;21750661;40997131", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005675 transcription factor TFIIH holo complex;GO:0005669 transcription factor TFIID complex;GO:0000438 core TFIIH complex portion of holo TFIIH complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006289 nucleotide-excision repair;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JIB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C4P6S0-1", "uniprot_id": "SHTAP_MOUSE", "mass": 86304.0, "length": 806, "protein_name": "Sperm head and tail associated protein", "gene_name": "Nsun4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Nsun4; Shtap", "gene_names_refseq": "", "protein_names_uniprotkb": "Sperm head and tail associated protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:72181)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19686095;21531335;21750661;24516400", "class_list": "", "function": "Mitochondrial RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as rRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:24516400). Involved in mitochondrial ribosome small subunit (SSU) maturation by catalyzing methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU) (PubMed:24516400). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled (By similarity). In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4 (By similarity). Also acts as a regulator of innate immunity by marking double-stranded mitochondrial RNAs(mt-dsRNAs) generated in response to stress: catalyzes m5C modification on mitochondrial RNAs, such as a mRNAs and lncRNAs, with a preference for the termini of light-strand lncRNAs, promoting their degradation and cytosolic release (By similarity). Modified light-strand lncRNAs are then recognized by C1QBP reader and recruited to the mitochondrial degradosome complex, which promotes their degradation (By similarity)., [UniProtKB, PubMed, UniProtKB]; Plays a role during spermatogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.-;2.1.1.203", "go_molecular_function": "GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity;GO:0016428 tRNA (cytidine-5-)-methyltransferase activity;GO:0000049 tRNA binding;GO:0008649 rRNA methyltransferase activity;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0031167 rRNA methylation;GO:0030488 tRNA methylation;GO:0006364 rRNA processing;GO:0000957 mitochondrial RNA catabolic process;GO:1902775 mitochondrial large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "C4P6S0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1L2-1", "uniprot_id": "SNG4_MOUSE", "mass": 25795.0, "length": 233, "protein_name": "Synaptogyrin-4", "gene_name": "Syngr4", "organism": "Mouse", "refseq_name": "synaptogyrin-4 isoform 2", "refseq_ac": "NP_001277993", "gene_names_uniprotkb": "Syngr4", "gene_names_refseq": "1700016O14Rik; Syngr4", "protein_names_uniprotkb": "Synaptogyrin-4", "protein_names_refseq": "synaptogyrin 4 protein; synaptogyrin-4 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:58867)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;32686835", "class_list": "", "function": "Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZT0;Q9DA94", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031594 neuromuscular junction;GO:0030672 synaptic vesicle membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z1L2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCI3-1", "uniprot_id": "STR3N_MOUSE", "mass": 26811.0, "length": 235, "protein_name": "STARD3 N-terminal-like protein", "gene_name": "Stard3nl", "organism": "Mouse", "refseq_name": "STARD3 N-terminal-like protein isoform a", "refseq_ac": "NP_077232", "gene_names_uniprotkb": "Stard3nl; Mentho", "gene_names_refseq": "0610035N01Rik; 6530409L22Rik; MENTHO; Stard3nl", "protein_names_uniprotkb": "STARD3 N-terminal-like protein; MLN64 N-terminal domain homolog", "protein_names_refseq": "MLN64 N-terminal domain homolog; STARD3 N-terminal-like protein isoform a; STARD3 N-terminal-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:76205); (R-MMU-196108)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19144319;21183079;21750661;26495903;30084848;30779550;34428180;35098646", "class_list": "", "function": "STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/beta-catenin pathway via binding to Annexin A2 in osteoporosis., [RefSeq, PubMed]; Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U8Q7;Q99J63;Q9D356", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005768 endosome;GO:0005789 endoplasmic reticulum membrane;GO:0031902 late endosome membrane;GO:0140284 endoplasmic reticulum-endosome membrane contact site", "go_biological_process": "GO:0030301 cholesterol transport;GO:0099044 vesicle tethering to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DCI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7I0-1", "uniprot_id": "SHSA5_MOUSE", "mass": 25517.0, "length": 235, "protein_name": "Protein shisa-5", "gene_name": "Shisa5", "organism": "Mouse", "refseq_name": "protein shisa-5 isoform 3 precursor", "refseq_ac": "NP_001271261", "gene_names_uniprotkb": "Shisa5; Scotin", "gene_names_refseq": "2310008D10Rik; 6430628I05Rik; Scotin; Shisa5; mShisa5", "protein_names_uniprotkb": "Protein shisa-5; Scotin", "protein_names_refseq": "protein shisa-5 isoform 3 precursor; protein shisa-5; shisa homolog 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:66940); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "12135983;17889823;18164684;18250455;18677103;20173027;21750661;21913724;25428506;26495903;34428180;39950214", "class_list": "", "function": "ALG-2 binding to Scotin is strictly calcium dependent, indicating a role of this interaction in calcium signaling pathways, [RefSeq, PubMed]; Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mouse Scotin induces apoptosis and developmental defects when overexpressed in Drosophila., [RefSeq, PubMed]; Scotin plays a role in p53-dependent apoptosis, [RefSeq, PubMed]; We conclude that Scotin is a new p63 target gene induced during epithelial differentiation, a complex process that also involves ER stress induction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJ86;Q8BJ87;Q8BLE9;Q8K4W3;Q91Z37;Q9CQP5", "ec_number_list": "", "go_molecular_function": "GO:0050699 WW domain binding;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060628 regulation of ER to Golgi vesicle-mediated transport;GO:1905898 positive regulation of response to endoplasmic reticulum stress;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator;GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9D7I0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TSE6-1", "uniprot_id": "ST38L_MOUSE", "mass": 53772.0, "length": 464, "protein_name": "Serine/threonine-protein kinase 38-like", "gene_name": "Stk38l", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase 38-like isoform 2", "refseq_ac": "NP_001333595", "gene_names_uniprotkb": "Stk38l; Ndr2", "gene_names_refseq": "4930473A22Rik; Ndr2; Ndr54; Stk38l", "protein_names_uniprotkb": "Serine/threonine-protein kinase 38-like; 2.7.11.1; NDR2 protein kinase; Nuclear Dbf2-related kinase 2", "protein_names_refseq": "nuclear Dbf2-related kinase 2; serine/threonine-protein kinase 38-like isoform 2; serine/threonine-protein kinase 38-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:232533)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15037617;15308672;21730291;21750661;25428506;25601544;34428180;36417850", "class_list": "", "function": "Involved in the regulation of structural processes in differentiating and mature neuronal cells., [UniProtKB, PubMed, PubMed]; LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation., [RefSeq, PubMed]; NDR1/2 functions as a physiological YAP1 kinase in the intestinal epithelium., [RefSeq, PubMed]; Ndr2 is an interesting candidate gene for the regulation of structural processes in differentiating and mature neuronal cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2KFR4;Q6P6K6;Q8BWK4", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003779 actin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0010507 negative regulation of autophagy;GO:0010508 positive regulation of autophagy;GO:0051128 regulation of cellular component organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7TSE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q499E5-1", "uniprot_id": "STOX2_MOUSE", "mass": 102757.0, "length": 926, "protein_name": "Storkhead-box protein 2", "gene_name": "Stox2", "organism": "Mouse", "refseq_name": "storkhead-box protein 2 isoform 1", "refseq_ac": "NP_001107783", "gene_names_uniprotkb": "Stox2; Kiaa1392", "gene_names_refseq": "4933409N07Rik; Stox2; mKIAA1392", "protein_names_uniprotkb": "Storkhead-box protein 2", "protein_names_refseq": "storkhead-box protein 2 isoform 1; storkhead-box protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71069)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22517741;22645316;40885482", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B2RR59;Q3TRF0;Q497F9;Q6ZPS3;Q8CDI1", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009617 response to bacterium;GO:0001893 maternal placenta development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q499E5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925E0-1", "uniprot_id": "SNTG2_MOUSE", "mass": 59598.0, "length": 539, "protein_name": "Gamma-2-syntrophin", "gene_name": "Sntg2", "organism": "Mouse", "refseq_name": "gamma-2-syntrophin isoform 1", "refseq_ac": "NP_766539", "gene_names_uniprotkb": "Sntg2", "gene_names_refseq": "2210008K22Rik; 9530013L23; G2syn; Sntg2; Syn5", "protein_names_uniprotkb": "Gamma-2-syntrophin; G2SYN; SYN5; Syntrophin-5", "protein_names_refseq": "gamma-2-syntrophin isoform 1; gamma-2-syntrophin; syntrophin-5", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (mmu:268534); (R-MMU-9913351)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16857187;21750661", "class_list": "", "function": "Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity)., [UniProtKB]; Gamma1-Syntrophin is highly expressed in brain and is specifically localized in hippocampal pyramidal neurons, Purkinje neurons in cerebellum, and cortical neurons. gamma2-Syntrophin is expressed in many tissues including skeletal muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSQ0", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005198 structural molecule activity;GO:0030165 PDZ domain binding;GO:0097109 neuroligin family protein binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005654 nucleoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0042383 sarcolemma", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q925E0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64705-1", "uniprot_id": "USF2_MOUSE", "mass": 36954.0, "length": 346, "protein_name": "Upstream stimulatory factor 2", "gene_name": "Usf2", "organism": "Mouse", "refseq_name": "upstream stimulatory factor 2 isoform 1", "refseq_ac": "NP_035810", "gene_names_uniprotkb": "Usf2", "gene_names_refseq": "Usf-2; Usf2; bHLHb12", "protein_names_uniprotkb": "Upstream stimulatory factor 2; Major late transcription factor 2; Upstream transcription factor 2", "protein_names_refseq": "major late transcription factor 2; upstream stimulatory factor 2 isoform 1; upstream stimulatory factor 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22282); (R-MMU-9018519)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "21750661;34428180;36905106;37097016;37341818;37347361;37914905;40997131;7523363;7774954;8127680;9070273", "class_list": "", "function": "A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence., [RefSeq, PubMed]; Knockdown of USF2 inhibits pyroptosis of podocytes and attenuates kidney injury in lupus nephritis., [RefSeq, PubMed]; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; USF2 activates RhoB/ROCK pathway by transcriptional inhibition of miR-206 to promote pyroptosis in septic cardiomyocytes., [RefSeq, PubMed]; Usf2 Deficiency Promotes Autophagy to Alleviate Cerebral Ischemia-Reperfusion Injury Through Suppressing YTHDF1-m6A-Mediated Cdc25A Translation., [RefSeq, PubMed]; WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIL2;Q8VE59", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0055088 lipid homeostasis;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q64705-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D287-1", "uniprot_id": "SPF27_MOUSE", "mass": 26131.0, "length": 225, "protein_name": "Pre-mRNA-splicing factor SPF27", "gene_name": "Bcas2", "organism": "Mouse", "refseq_name": "pre-mRNA-splicing factor SPF27 isoform 1", "refseq_ac": "NP_080878", "gene_names_uniprotkb": "Bcas2; Dam1", "gene_names_refseq": "6430539P16Rik; Bcas2", "protein_names_uniprotkb": "Pre-mRNA-splicing factor SPF27; Breast carcinoma-amplified sequence 2 homolog; DNA amplified in mammary carcinoma 1 protein", "protein_names_refseq": "DNA amplified in mammary carcinoma 1 protein; breast carcinoma amplified sequence 2; breast carcinoma-amplified sequence 2 homolog; pre-mRNA-splicing factor SPF27 isoform 1; pre-mRNA-splicing factor SPF27", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:68183); (R-MMU-72163)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;12406557;21750661;26319152;26428007;27713508;28135057;31219806;34428180;37820033;37828378;38085152", "class_list": "", "function": "BCAS2 Participates in Insulin Synthesis and Secretion via mRNA Alternative Splicing in Mice. Erratum:[Endocrinology. 2024 Jul 26;165(9):bqae096. doi: 10.1210/endocr/bqae096. PMID: 39092924], [RefSeq, PubMed]; BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination., [RefSeq, PubMed]; BCAS2 is an upstream regulator of beta-catenin gene expression and plays a role in dendrite growth at least partly through beta-catenin in the forebrain. Publication Status: Online-Only, [RefSeq, PubMed]; BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing., [RefSeq, PubMed]; Maternal BCAS2 protects genomic integrity in mouse early embryonic development., [RefSeq, PubMed]; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKJ5;Q91YX8;Q9D2U4;Q9DAI0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0007611 learning or memory;GO:0016358 dendrite development;GO:0097061 dendritic spine organization;GO:0048813 dendrite morphogenesis;GO:0001541 ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9D287-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99ME3-1", "uniprot_id": "SNCAP_MOUSE", "mass": 105607.0, "length": 962, "protein_name": "Synphilin-1", "gene_name": "Sncaip", "organism": "Mouse", "refseq_name": "synphilin-1 isoform 1", "refseq_ac": "NP_001186080", "gene_names_uniprotkb": "Sncaip", "gene_names_refseq": "2810407O15Rik; 4933427B05Rik; SYPH1; Sncaip", "protein_names_uniprotkb": "Synphilin-1; Alpha-synuclein-interacting protein", "protein_names_refseq": "alpha-synuclein-interacting protein; synphilin-1 isoform 1; synphilin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67847)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;34595918;35773260;35830804;40021952", "class_list": "", "function": "Accumulation of Prion and Abnormal Prion Protein Induces Hyperphosphorylation of alpha-Synuclein in the Brain Tissues from Prion Diseases and in the Cultured Cells., [RefSeq, PubMed]; P21-activated kinase 4 controls the aggregation of alpha-synuclein by reducing the monomeric and aggregated forms of alpha-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1. Publication Status: Online-Only, [RefSeq, PubMed]; Treadmill exercise reduces alpha-synuclein spreading via PPARalpha. Erratum:[Cell Rep. 2024 Aug 27;43(8):114546. doi: 10.1016/j.celrep.2024.114546. PMID: 39024097], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2BDD1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0046928 regulation of neurotransmitter secretion;GO:0042417 dopamine metabolic process;GO:0090083 regulation of inclusion body assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99ME3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERB5-1", "uniprot_id": "SO1C1_MOUSE", "mass": 78320.0, "length": 715, "protein_name": "Solute carrier organic anion transporter family member 1C1", "gene_name": "Slco1c1", "organism": "Mouse", "refseq_name": "solute carrier organic anion transporter family member 1C1 isoform 2", "refseq_ac": "NP_001171243", "gene_names_uniprotkb": "Slco1c1; Oatp1c1; Oatpf; Slc21a14", "gene_names_refseq": "OATP-14; OATP-F; Oatp2; Oatpf; Slc21a14; Slco1c1", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 1C1; OATP-14; OATP-F; OATP2; Organic anion transporter 2; Organic anion transporter F; Organic anion-transporting polypeptide 14; Solute carrier family 21 member 14; Thyroxine transporter", "protein_names_refseq": "organic anion transporter 2; organic anion transporter F; organic anion-transporting polypeptide 14; solute carrier family 21 (organic anion transporter), member 14; solute carrier organic anion transporter family member 1C1 isoform 2; thyroxine transporter", "tax_id": 10090, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236)", "pathway": " (mmu:58807); (R-MMU-879518)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;15166123;18687783;21750661;22294745;24691440;30084848;40021952", "class_list": "", "function": "Basolateral localization of mOatp14 in the choroid plexus in which it may also play a role in T4 uptake., [RefSeq, PubMed]; Mediates the Na(+)-independent high affinity transport of thyroid hormones at the plasma membrane of brain capillary endothelial cells (PubMed:15166123, PubMed:22294745, PubMed:24691440). The transport activity of substrates L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) is much greater than that of 3,3',5-triiodo-L-thyronine (T3) (PubMed:15166123). The prehormone, T4, is the major form in the circulating blood and is converted to the active form, T3, by the iodothyronine-deiodinase in peripheral organs (PubMed:15166123). T3 plays an essential role in brain development via binding to specific nuclear receptors (thyroid hormone receptor) (PubMed:15166123, PubMed:22294745). Also transports organic anions such as the conjugated steroid 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)) (PubMed:15166123). Transports T4 and estrone-3-sulfate in a pH-insensitive manner (By similarity). May serve as a drug efflux system at the blood brain barrier (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8BX54", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity;GO:0015349 thyroid hormone transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0055085 transmembrane transport;GO:0015721 bile acid and bile salt transport;GO:0043252 sodium-independent organic anion transport;GO:2000611 positive regulation of thyroid hormone generation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9ERB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91XA5-1", "uniprot_id": "SNPC2_MOUSE", "mass": 38370.0, "length": 359, "protein_name": "snRNA-activating protein complex subunit 2", "gene_name": "Snapc2", "organism": "Mouse", "refseq_name": "snRNA-activating protein complex subunit 2", "refseq_ac": "NP_598729", "gene_names_uniprotkb": "Snapc2", "gene_names_refseq": "0610007H10Rik; Snapc2", "protein_names_uniprotkb": "snRNA-activating protein complex subunit 2; SNAPc 45 kDa subunit; SNAPc subunit 2; Small nuclear RNA-activating complex polypeptide 2; snRNA-activating protein complex 45 kDa subunit", "protein_names_refseq": "SNAPc 45 kDa subunit; SNAPc subunit 2; snRNA-activating protein complex 45 kDa subunit; snRNA-activating protein complex subunit 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:102209); (R-MMU-6807505); (R-MMU-76071)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;25428506;25605945", "class_list": "", "function": "Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UK17;Q8CBS9", "ec_number_list": "", "go_molecular_function": "GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0019185 snRNA-activating protein complex", "go_biological_process": "GO:0009301 snRNA transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91XA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZX4-1", "uniprot_id": "SREK1_MOUSE", "mass": 56763.0, "length": 494, "protein_name": "Splicing regulatory glutamine/lysine-rich protein 1", "gene_name": "Srek1", "organism": "Mouse", "refseq_name": "splicing regulatory glutamine/lysine-rich protein 1 isoform 2", "refseq_ac": "NP_766180", "gene_names_uniprotkb": "Srek1; Sfrs12; Srrp86", "gene_names_refseq": "8430401B01; SRrp508; SRrp86; Sfrs12; Srek1; Srsf12", "protein_names_uniprotkb": "Splicing regulatory glutamine/lysine-rich protein 1; SRrp86; Serine/arginine-rich-splicing regulatory protein 86; Splicing factor, arginine/serine-rich 12", "protein_names_refseq": "serine/arginine-rich splicing factor 12; serine/arginine-rich-splicing regulatory protein 86; splicing regulatory glutamine/lysine-rich protein 1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:218543)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;36852467;40997131", "class_list": "", "function": "Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLM8;Q8BWK7;Q8BYK0;Q8BYZ4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BZX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CI59-1", "uniprot_id": "STEA3_MOUSE", "mass": 54749.0, "length": 488, "protein_name": "Metalloreductase STEAP3", "gene_name": "Steap3", "organism": "Mouse", "refseq_name": "metalloreductase STEAP3 isoform b", "refseq_ac": "NP_001078878", "gene_names_uniprotkb": "Steap3; Tsap6", "gene_names_refseq": "1010001D01Rik; Steap3; Tsap6; pHyde", "protein_names_uniprotkb": "Metalloreductase STEAP3; 1.16.1.-; Dudulin-2; Protein nm1054; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6", "protein_names_refseq": "dudulin 2; metalloreductase STEAP3 isoform b; metalloreductase STEAP3; protein nm1054; six-transmembrane epithelial antigen of prostate 3; tumor suppressor-activated pathway protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:68428); (R-MMU-6803204); (R-MMU-9013406); (R-MMU-9035034); (R-MMU-917977)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "12606722;16227996;16609065;17242355;18955558;19144319;21183079;21750661;31219806;31393024;32862709;34428180", "class_list": "", "function": "Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:16227996, PubMed:16609065, PubMed:18955558). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (PubMed:16609065). Mediates efficient transferrin-dependent iron uptake in erythroid cells (PubMed:16227996). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; STEAP3 (Six-Transmembrane Epithelial Antigen of Prostate 3) Inhibits Pathological Cardiac Hypertrophy., [RefSeq, PubMed]; Six-Transmembrane Epithelial Antigen of the Prostate 3 Deficiency in Hepatocytes Protects the Liver Against Ischemia-Reperfusion Injury by Suppressing Transforming Growth Factor-beta-Activated Kinase 1., [RefSeq, PubMed]; TSAP6 may augment Myt1 activity and act downstream to p53 to interface apoptosis and cell-cycle progression, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKE4;Q80ZF3;Q8C5F0;Q924Z1", "ec_number_list": "2.7.11.1;3.6.5.2;3.4.22.-;3.6.4.-;1.16.1.-;2.3.2.26;3.1.3.-;3.1.3.95", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0020037 heme binding;GO:0008823 cupric reductase (NADH) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0005771 multivesicular body", "go_biological_process": "GO:1990182 exosomal secretion;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0009306 protein secretion;GO:0015677 copper ion import", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8CI59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47226-1", "uniprot_id": "TES_MOUSE", "mass": 47983.0, "length": 423, "protein_name": "Testin", "gene_name": "Tes", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tes", "gene_names_refseq": "", "protein_names_uniprotkb": "Testin; TES1/TES2", "protein_names_refseq": "", "tax_id": 10090, "disease": "childhood acute lymphocytic leukemia (Disease Ontology:DOID:0080144); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); endometrial carcinoma (Disease Ontology:DOID:2871); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); uterine corpus sarcoma (Disease Ontology:DOID:5165); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "16033868;21278383;21750661;34428180;37828378;7758969", "class_list": "", "function": "Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0030054 cell junction", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P47226-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56677-1", "uniprot_id": "ST14_MOUSE", "mass": 94655.0, "length": 855, "protein_name": "Suppressor of tumorigenicity 14 protein homolog", "gene_name": "St14", "organism": "Mouse", "refseq_name": "suppressor of tumorigenicity 14 protein homolog", "refseq_ac": "NP_035306", "gene_names_uniprotkb": "St14; Prss14", "gene_names_refseq": "Epithin; MT-SP1; Prss14; St14; Tmprss14; mCAP3; matriptase", "protein_names_uniprotkb": "Suppressor of tumorigenicity 14 protein homolog; 3.4.21.109; Epithin; Serine protease 14", "protein_names_refseq": "matriptase/MT-SP1; protease, serine, 14 (epithin); suppressor of tumorigenicity 14 protein homolog", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); autosomal recessive congenital ichthyosis 11 (Disease Ontology:DOID:0060720); Sjogren's syndrome (Disease Ontology:DOID:12894); granulosa cell tumor (Disease Ontology:DOID:2999); dysgerminoma (Disease Ontology:DOID:4441); renal cell carcinoma (Disease Ontology:DOID:4450); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (mmu:19143)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10199918;12032844;14551220;19349973;21183079;21750661;31628112;32152506;32907879;37539662;37830556", "class_list": "", "function": "Early-onset tufting enteropathy in HAI-2-deficient mice is independent of matriptase-mediated cleavage of EpCAM., [RefSeq, PubMed]; Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (By similarity). Proteolytically cleaves and therefore activates TMPRSS13 (By similarity)., [UniProtKB, UniProtKB]; Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity. Publication Status: Online-Only, [RefSeq, PubMed]; Matriptase is a causative agent in the development of congenital tufting enteropathy (CTE) and may provide a new target for the treatment of CTE in individuals carrying SPINT2 mutation Publication Status: Online-Only, [RefSeq, PubMed]; Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis. (Matriptase/MTSP1), [RefSeq, PubMed]; Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.109", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0060672 epithelial cell morphogenesis involved in placental branching;GO:0006508 proteolysis;GO:0016477 cell migration;GO:0016485 protein processing;GO:0030216 keratinocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P56677-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8T7-1", "uniprot_id": "SLIRP_MOUSE", "mass": 12605.0, "length": 112, "protein_name": "SRA stem-loop-interacting RNA-binding protein, mitochondrial", "gene_name": "Slirp", "organism": "Mouse", "refseq_name": "SRA stem-loop-interacting RNA-binding protein, mitochondrial", "refseq_ac": "NP_081234", "gene_names_uniprotkb": "Slirp; 1810035L17Rik", "gene_names_refseq": "1810035L17Rik; Slirp", "protein_names_uniprotkb": "SRA stem-loop-interacting RNA-binding protein, mitochondrial", "protein_names_refseq": "SRA stem-loop-interacting RNA-binding protein, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:380773)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19131326;19680543;21750661;23976951;25605945;26247782;29146908;37507081", "class_list": "", "function": "Both LRPPRC and SLIRP are required for maintaining mt-mRNA steady-state levels independent of their roles in stabilizing the other partner of the LRPPRC-SLIRP complex. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation (By similarity)., [UniProtKB]; SLIRP plays an essential role in maintaining mitochondrial-localized mRNA transcripts that encode OxPhos protein subunits. Erratum:[PLoS Genet. 2010;6(3). doi: 10.1371/annotation/36fe7624-0904-46d4-a013-4be6195245c4], [RefSeq, PubMed]; SLIRP regulates male fertility, wherein its loss results in asthenozoospermia associated with compromised sperm structure and mitochondrial morphology. Publication Status: Online-Only, [RefSeq, PubMed]; Study demonstrated that the LRPPRC-SLIRP complex is a global RNA chaperone that stabilizes RNA structures to expose the required sites for translation, stabilization, and polyadenylation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497G4;Q99JH3", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0034046 poly(G) binding;GO:0003676 nucleic acid binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D8T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40630-1", "uniprot_id": "TFAM_MOUSE", "mass": 27988.0, "length": 243, "protein_name": "Transcription factor A, mitochondrial", "gene_name": "Tfam", "organism": "Mouse", "refseq_name": "transcription factor A, mitochondrial precursor", "refseq_ac": "NP_033386", "gene_names_uniprotkb": "Tfam; Hmgts", "gene_names_refseq": "Hmgts; Tfam; mtTFA; tsHMG", "protein_names_uniprotkb": "Transcription factor A, mitochondrial; TS-HMG; Testis-specific high mobility group protein; mtTFA", "protein_names_refseq": "TS-HMG; testis-specific HMG-box protein m-tsHMG; testis-specific high mobility group protein; transcription factor A, mitochondrial precursor", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 15 (Disease Ontology:DOID:0080337); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858); Kearns-Sayre syndrome (Disease Ontology:DOID:12934); Parkinson's disease (Disease Ontology:DOID:14330); status epilepticus (Disease Ontology:DOID:1824); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:21780); (R-MMU-163282); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17581862;21750661;23806337;8321234;8673128;9500544", "class_list": "", "function": "Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (By similarity). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (By similarity). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (By similarity). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (By similarity). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (By similarity). Is able to unwind DNA (By similarity). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (By similarity). Required for maintenance of normal levels of mitochondrial DNA (PubMed:9500544). May play a role in organizing and compacting mitochondrial DNA (PubMed:17581862)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; May also function as a transcriptional activator or may have a structural role in the compaction of nuclear DNA during spermatogenesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97894;P97906;Q543I8;Q9DBM9", "ec_number_list": "", "go_molecular_function": "GO:0001018 mitochondrial promoter sequence-specific DNA binding;GO:0003682 chromatin binding;GO:0031072 heat shock protein binding;GO:0043565 sequence-specific DNA binding;GO:0001223 transcription coactivator binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0032991 protein-containing complex", "go_biological_process": "GO:0033108 mitochondrial respiratory chain complex assembly;GO:0006391 transcription initiation at mitochondrial promoter;GO:0007584 response to nutrient;GO:0001666 response to hypoxia;GO:0006390 mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P40630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97499-1", "uniprot_id": "TEP1_MOUSE", "mass": 291460.0, "length": 2629, "protein_name": "Telomerase protein component 1", "gene_name": "Tep1", "organism": "Mouse", "refseq_name": "telomerase protein component 1", "refseq_ac": "NP_033377", "gene_names_uniprotkb": "Tep1; Tp1", "gene_names_refseq": "Tep1; Tp1", "protein_names_uniprotkb": "Telomerase protein component 1; Telomerase protein 1; Telomerase-associated protein 1; p240; p80 telomerase homolog", "protein_names_refseq": "p240; p80 homolog; p80 telomerase homolog; telomerase protein 1; telomerase protein component 1", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:21745)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10551828;11149928;21750661;25428506;31219806;31599954;32782141;34428180;35820727;36210013;37828378;9020079;9118230", "class_list": "", "function": "Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (By similarity). Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction (PubMed:11149928). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle (PubMed:11149928)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0002039 p53 binding;GO:0003720 telomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:1990904 ribonucleoprotein complex;GO:0005697 telomerase holoenzyme complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000722 telomere maintenance via recombination", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P97499-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFG0-1", "uniprot_id": "SULF2_MOUSE", "mass": 100497.0, "length": 875, "protein_name": "Extracellular sulfatase Sulf-2", "gene_name": "Sulf2", "organism": "Mouse", "refseq_name": "extracellular sulfatase Sulf-2 isoform 1 precursor", "refseq_ac": "NP_001239507", "gene_names_uniprotkb": "Sulf2", "gene_names_refseq": "2010004N24Rik; MSulf-2; Sulf2; mKIAA1247", "protein_names_uniprotkb": "Extracellular sulfatase Sulf-2; 3.1.6.14; 3.1.6.1; Arylsulfatase; N-acetylglucosamine-6-sulfatase; mSulf-2", "protein_names_refseq": "N-acetylglucosamine-6-sulfatase; arylsulfatase; extracellular sulfatase Sulf-2 isoform 1 precursor; extracellular sulfatase Sulf-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72043)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12368295;21750661;26495903;26740625;28011936;30084848;30899004;31599954;34428180;35472437;35820727;35984892", "class_list": "glycogene", "function": "Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (By similarity). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (By similarity)., [UniProtKB, UniProtKB]; SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer., [RefSeq, PubMed]; Sulfs are extracellular endosulfatases with strong potential for modulating the interactions of heparan sulfate proteoglycans in the extracellular microenvironment, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 61, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "B2RUD5;Q3TNM3;Q8BM68;Q8BUZ4;Q8BX28;Q8BZ51;Q8C169;Q9D8E2", "ec_number_list": "3.1.6.1;3.1.6.15;3.1.6.14;3.1.6.18", "go_molecular_function": "GO:0008449 N-acetylglucosamine-6-sulfatase activity;GO:0005509 calcium ion binding;GO:0004065 arylsulfatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0030201 heparan sulfate proteoglycan metabolic process;GO:0060384 innervation;GO:2000345 regulation of hepatocyte proliferation;GO:0014846 esophagus smooth muscle contraction;GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8CFG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMD1-1", "uniprot_id": "SMBT1_MOUSE", "mass": 97338.0, "length": 863, "protein_name": "Scm-like with four MBT domains protein 1", "gene_name": "Sfmbt1", "organism": "Mouse", "refseq_name": "scm-like with four MBT domains protein 1", "refseq_ac": "NP_001160003", "gene_names_uniprotkb": "Sfmbt1", "gene_names_refseq": "4930442N21Rik; 9330180L21Rik; Sfmbt1; Sfmbt; Smr", "protein_names_uniprotkb": "Scm-like with four MBT domains protein 1", "protein_names_refseq": "Scm-related gene containing four mbt domains 1; scm-like with four MBT domains protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:54650)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10806358;21183079;21750661;23349461;23592795;30442713", "class_list": "", "function": "Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZD3;Q8CFS1", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0048635 negative regulation of muscle organ development;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JMD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U1N2-1", "uniprot_id": "SRBP2_MOUSE", "mass": 122911.0, "length": 1130, "protein_name": "Sterol regulatory element-binding protein 2", "gene_name": "Srebf2", "organism": "Mouse", "refseq_name": "sterol regulatory element-binding protein 2 isoform 1", "refseq_ac": "NP_150087", "gene_names_uniprotkb": "Srebf2; Srebp2", "gene_names_refseq": "SREBP-2; SREBP2gc; SREBP2; Srebf2; bHLHd2; lop13; nuc", "protein_names_uniprotkb": "Sterol regulatory element-binding protein 2; SREBP-2; Sterol regulatory element-binding transcription factor 2; Transcription factor SREBF2", "protein_names_refseq": "sterol regulatory element-binding protein 2 isoform 1; sterol regulatory element-binding protein 2; sterol regulatory element-binding transcription factor 2", "tax_id": 10090, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); heart conduction disease (Disease Ontology:DOID:10273); prostate cancer (Disease Ontology:DOID:10283); sarcoma (Disease Ontology:DOID:1115); alcohol use disorder (Disease Ontology:DOID:1574); nephrosis (Disease Ontology:DOID:2527); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); kidney disease (Disease Ontology:DOID:557); end stage renal disease (Disease Ontology:DOID:783); vascular dementia (Disease Ontology:DOID:8725); type 2 diabetes mellitus (Disease Ontology:DOID:9352); lipid storage disease (Disease Ontology:DOID:9455); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20788); (R-MMU-1655829); (R-MMU-6807062)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "10397761;11283257;11929849;11994399;12668174;16100574;20173027;21459323;21750661;25605945;26311497;28849786;31219806;34203471;34428180;34678516;35820727;36056653;36852467;38861834;40885482;9616204", "class_list": "", "function": "Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:9616204, PubMed:36056653). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:9616204)., [UniProtKB, UniProtKB, PubMed, PubMed]; Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (By similarity). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:16100574, PubMed:9616204)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q925C2;Q9ESZ4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008203 cholesterol metabolic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q3U1N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q70E20-1", "uniprot_id": "SNED1_MOUSE", "mass": 151581.0, "length": 1403, "protein_name": "Sushi, nidogen and EGF-like domain-containing protein 1", "gene_name": "Sned1", "organism": "Mouse", "refseq_name": "sushi, nidogen and EGF-like domain-containing protein 1 precursor", "refseq_ac": "NP_766051", "gene_names_uniprotkb": "Sned1; Snep", "gene_names_refseq": "6720455I24Rik; D430044C15Rik; SST3; Sned1; Snep", "protein_names_uniprotkb": "Sushi, nidogen and EGF-like domain-containing protein 1; Secreted protein SST-3; Stromal nidogen extracellular matrix protein", "protein_names_refseq": "secreted nidogen domain protein; secreted protein SST-3; secreted protein SST3; stromal nidogen extracellular matrix protein; sushi, nidogen and EGF-like domain-containing protein 1 precursor; sushi, nidogen and EGF-like domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:208777)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12665856;15162516;21750661;33012048;33724335", "class_list": "", "function": "Comparative expression analysis of kidney stroma markers suggests that Snep is expressed in a specific subpopulation of stromal cells and may provide environmental cues to support regular development, [RefSeq, PubMed]; Knockout of the gene encoding the extracellular matrix protein SNED1 results in early neonatal lethality and craniofacial malformations., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "A6H6I3;Q810H2;Q8BMD9", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0071944 cell periphery", "go_biological_process": "GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q70E20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BJU0-1", "uniprot_id": "SGTA_MOUSE", "mass": 34322.0, "length": 315, "protein_name": "Small glutamine-rich tetratricopeptide repeat-containing protein alpha", "gene_name": "Sgta", "organism": "Mouse", "refseq_name": "small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 1", "refseq_ac": "NP_078775", "gene_names_uniprotkb": "Sgta; Sgt", "gene_names_refseq": "5330427H01Rik; D10Ertd190e; Sgta; Sgt; Stg", "protein_names_uniprotkb": "Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Alpha-SGT", "protein_names_refseq": "alpha-SGT; small glutamine-rich tetratricopeptide repeat (TPR) containing protein; small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform 1; small glutamine-rich tetratricopeptide repeat-containing protein alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:52551); (R-MMU-9609523)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;17034881;17242355;19131326;20173027;20484733;21183079;21750661;25428506;26169395;30084848;31219806;33757575;34203471;34428180;35820727;37507081", "class_list": "", "function": "Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SGTA associates with intracellular aggregates in neurodegenerative diseases. Publication Status: Online-Only, [RefSeq, PubMed]; The binding of SGTA to Rpn13 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGA6;Q99L52", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:1904288 BAT3 complex binding", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization;GO:0006457 protein folding;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q8BJU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1B9-1", "uniprot_id": "SLIT2_MOUSE", "mass": 168783.0, "length": 1521, "protein_name": "Slit homolog 2 protein", "gene_name": "Slit2", "organism": "Mouse", "refseq_name": "slit homolog 2 protein isoform c precursor", "refseq_ac": "NP_848919", "gene_names_uniprotkb": "Slit2", "gene_names_refseq": "Drad-1; E030015M03Rik; E130320P19Rik; Slil3; Slit2; b2b1200.1Clo; mKIAA4141; slit-2", "protein_names_uniprotkb": "Slit homolog 2 protein; Slit-2", "protein_names_refseq": "downregulated during adipocyte differentiation-1; neurogenic extracellular slit protein; slit homolog 2 protein isoform c precursor; slit homolog 2 protein", "tax_id": 10090, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); atrial fibrillation (Disease Ontology:DOID:0060224); polymyositis (Disease Ontology:DOID:0080745); dermatomyositis (Disease Ontology:DOID:10223); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); transient cerebral ischemia (Disease Ontology:DOID:224); cystic kidney disease (Disease Ontology:DOID:2975); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); diabetic retinopathy (Disease Ontology:DOID:8947); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:20563); (R-MMU-376176); (R-MMU-428890); (R-MMU-8985586); (R-MMU-9010553)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10349621;10433822;10864954;10864955;11804571;12097499;15130495;21750661;25894826", "class_list": "", "function": "Mutants lacking SLIT2 develop supernumerary ureteric buds that remain inappropriately connected to the nephric duct; the SLIT2 signal is transduced in the nephrogenic mesenchyme., [RefSeq, PubMed]; Slit2 signaling through Robo1 and Robo2 has a role in retinal neovascularization, [RefSeq, PubMed]; The protein encoded by this gene is a member of the Slit family of secreted glycoproteins, which function as ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. In mammals, members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Mice deficient for this gene exhibit abnormal axonal projections in the embryonic forebrain and develop supernumerary uretic buds that maintain improper connections to the nephric duct. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal cord development, may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal cord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system, appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration (By similarity)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 4, "disease_count": 13, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "E9QKB4;Q9Z166", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0090260 negative regulation of retinal ganglion cell axon guidance;GO:0002689 negative regulation of leukocyte chemotaxis;GO:0090027 negative regulation of monocyte chemotaxis;GO:0070100 negative regulation of chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9R1B9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z172-1", "uniprot_id": "SUMO3_MOUSE", "mass": 12430.0, "length": 110, "protein_name": "Small ubiquitin-related modifier 3", "gene_name": "Sumo3", "organism": "Mouse", "refseq_name": "small ubiquitin-related modifier 3 isoform 2", "refseq_ac": "NP_001288600", "gene_names_uniprotkb": "Sumo3; Smt3a; Smt3h1", "gene_names_refseq": "2810014B19Rik; D10Ertd345e; SMT3A; SUMO-3; Smt3h1; Sumo3", "protein_names_uniprotkb": "Small ubiquitin-related modifier 3; SMT3 homolog 1; SUMO-3; Smt3A; Ubiquitin-like protein SMT3A", "protein_names_refseq": "SMT3 suppressor of mif two 3 homolog 3; small ubiquitin-related modifier 3 isoform 2; small ubiquitin-related modifier 3; ubiquitin-like protein SMT3A", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:20610); (R-MMU-3065679); (R-MMU-3108214); (R-MMU-3232118); (R-MMU-3899300); (R-MMU-4090294); (R-MMU-4551638); (R-MMU-4615885); (R-MMU-4755510); (R-MMU-5696395)", "pathway_count": 10, "publication_count": 7, "publication_id_list": "17012228;17077080;18644859;21750661;28528544;37890757;9891849", "class_list": "", "function": "Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice., [RefSeq, PubMed]; P53 and pRB can be sumoylated by SUMO-2/3 in vivo, and such modification of p53 and pRB may play roles in premature senescence and stress response, [RefSeq, PubMed]; SUMO-2/3 proteins conjugate to c-Myb transcription factor and negatively regulate its activity in cells under stress., [RefSeq, PubMed]; This gene encodes a member of the small ubiquitin-like modifier family. The encoded protein may regulate a variety of proteins in many pathways via a post-translational modification, known as SUMOylation. This activity may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Disruption of some of these processes has been associated with cerebral ischemia, neural dysfunction, and heart disease. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]., [RefSeq]; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX., [UniProtKB, UniProtKB, UniProtKB]; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14C17;Q3TBL9;Q3UDI5", "ec_number_list": "", "go_molecular_function": "GO:0019789 SUMO transferase activity;GO:0044389 ubiquitin-like protein ligase binding;GO:0031386 protein tag activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0016605 PML body", "go_biological_process": "GO:0016925 protein sumoylation;GO:0034504 protein localization to nucleus;GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process;GO:1900180 regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z172-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNL3-1", "uniprot_id": "STK40_MOUSE", "mass": 48932.0, "length": 435, "protein_name": "Serine/threonine-protein kinase 40", "gene_name": "Stk40", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase 40 isoform a", "refseq_ac": "NP_001139299", "gene_names_uniprotkb": "Stk40; Lyk4", "gene_names_refseq": "2310004N11Rik; Stk40", "protein_names_uniprotkb": "Serine/threonine-protein kinase 40; 2.7.11.1; Serine/threonine-protein kinase lyk4", "protein_names_refseq": "ortholog of Ser/Thr-like protein kinase Lyk4; serine/threonine-protein kinase 40 isoform a; serine/threonine-protein kinase 40; serine/threonine-protein kinase lyk4", "tax_id": 10090, "disease": "", "pathway": " (mmu:74178)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15893606;20080709;21750661;25428506;25605945;28358362;30084848;30779550;32657761;34428180", "class_list": "", "function": "Comparison of microarray data between wild type and Stk40(-/-) E14.5 fetal liver cells reveals a potential role of aberrantly activated TNF-alpha signaling in Stk40 depletion induced dyserythropoiesis with a concomitant increase in cleaved caspase-3 and decrease in Gata1 proteins. Publication Status: Online-Only, [RefSeq, PubMed]; EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression., [RefSeq, PubMed]; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription., [UniProtKB]; Report identification of a target gene of Oct4, serine/threonine kinase 40 (Stk40), which is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse embryonic stem cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AW01;Q3U3G3;Q811D6;Q8BKT1;Q9D7K3", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0003016 respiratory system process;GO:0043066 negative regulation of apoptotic process;GO:0048286 lung alveolus development;GO:0005977 glycogen metabolic process;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7TNL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59941-1", "uniprot_id": "SIR6_MOUSE", "mass": 36920.0, "length": 334, "protein_name": "NAD-dependent protein deacylase sirtuin-6", "gene_name": "Sirt6", "organism": "Mouse", "refseq_name": "NAD-dependent protein deacylase sirtuin-6 isoform 1", "refseq_ac": "NP_853617", "gene_names_uniprotkb": "Sirt6; Sir2l6", "gene_names_refseq": "2810449N18Rik; Sir2l6; Sirt6; mSIRT6", "protein_names_uniprotkb": "NAD-dependent protein deacylase sirtuin-6; 2.3.1.-; 2.3.1.286; 2.4.2.-; NAD-dependent protein deacetylase sirtuin-6; Protein mono-ADP-ribosyltransferase sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2-like protein 6; mSIRT6", "protein_names_refseq": "NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacylase sirtuin-6 isoform 1; NAD-dependent protein deacylase sirtuin-6; SIR2-like protein 6; protein mono-ADP-ribosyltransferase sirtuin-6; regulatory protein SIR2 homolog 6", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); transient cerebral ischemia (Disease Ontology:DOID:224); progeria (Disease Ontology:DOID:3911); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:50721); (R-MMU-5685939); (R-MMU-5693607)", "pathway_count": 3, "publication_count": 46, "publication_id_list": "15795229;16439206;18242175;18388907;19135889;19151729;19220062;19597350;20141841;20816089;20847051;21098266;21680843;21750661;22367546;23142079;23217706;23552949;23911928;23974119;25009184;25083875;25247314;25915124;27180906;27322069;27457971;28250020;28355567;28448551;28723567;28871079;29555651;29599436;29717979;30530497;30782483;30853213;31002797;31216030;31399344;31442424;31851938;32538779;32584788;34050173", "class_list": "", "function": "Levels of the mammalian sirtuin, SIRT6, increased upon nutrient deprivation in cultured cells, in mice after fasting, and in rats fed a calorie-restricted diet., [RefSeq, PubMed]; NAD-dependent protein deacetylase, deacylase and mono-ADP-ribosyltransferase that plays an essential role in DNA damage repair, telomere maintenance, metabolic homeostasis, inflammation, tumorigenesis and aging (PubMed:16439206, PubMed:19135889, PubMed:19220062, PubMed:19597350, PubMed:20141841, PubMed:23217706, PubMed:23911928, PubMed:27180906, PubMed:29599436). Displays protein-lysine deacetylase or defatty-acylase (demyristoylase and depalmitoylase) activity, depending on the context (By similarity). Acts as a key histone deacetylase by catalyzing deacetylation of histone H3 at 'Lys-9', 'Lys-18' and 'Lys-56' (H3K9ac, H3K18ac and H3K56ac, respectively), suppressing target gene expression of several transcription factors, including NF-kappa-B (PubMed:19135889, PubMed:19597350, PubMed:20816089, PubMed:21098266, PubMed:25915124, PubMed:28871079, PubMed:31002797, PubMed:31399344). Acts as an inhibitor of transcription elongation by mediating deacetylation of H3K9ac and H3K56ac, preventing release of NELFE from chromatin and causing transcriptional pausing (PubMed:31399344). Involved in DNA repair by promoting double-strand break (DSB) repair: acts as a DSB sensor by recognizing and binding DSB sites, leading to (1) recruitment of DNA repair proteins, such as SMARCA5/SNF2H, and (2) deacetylation of histone H3K9ac and H3K56ac (PubMed:32538779). SIRT6 participation to DSB repair is probably involved in extension of life span (PubMed:22367546, PubMed:31002797). Also promotes DNA repair by deacetylating non-histone proteins, such as DDB2 and p53/TP53 (By similarity). Specifically deacetylates H3K18ac at pericentric heterochromatin, thereby maintaining pericentric heterochromatin silencing at centromeres and protecting against genomic instability and cellular senescence (By similarity). Involved in telomere maintenance by catalyzing deacetylation of histone H3 in telomeric chromatin, regulating telomere position effect and telomere movement in response to DNA damage (PubMed:29599436). Required for embryonic stem cell differentiation by mediating histone deacetylation of H3K9ac (PubMed:25915124, PubMed:29555651). Plays a major role in metabolism by regulating processes such as glycolysis, gluconeogenesis, insulin secretion and lipid metabolism (PubMed:20141841, PubMed:20816089, PubMed:20847051, PubMed:21098266, PubMed:23974119, PubMed:27457971, PubMed:28250020, PubMed:28355567, PubMed:34050173). Inhibits glycolysis via histone deacetylase activity and by acting as a corepressor of the transcription factor HIF1A, thereby controlling the expression of multiple glycolytic genes (PubMed:20141841). Has tumor suppressor activity by repressing glycolysis, thereby inhibiting the Warburg effect (PubMed:23217706). Also regulates glycolysis and tumorigenesis by mediating deacetylation and nuclear export of non-histone proteins, such as isoform M2 of PKM (PKM2) (By similarity). Acts as a negative regulator of gluconeogenesis by mediating deacetylation of non-histone proteins, such as FOXO1 and KAT2A/GCN5 (PubMed:23142079, PubMed:25009184). Promotes beta-oxidation of fatty acids during fasting by catalyzing deacetylation of NCOA2, inducing coactivation of PPARA (PubMed:31851938). Acts as a regulator of lipid catabolism in brown adipocytes, both by catalyzing deacetylation of histones and non-histone proteins, such as FOXO1 (PubMed:28723567, PubMed:31442424). Also acts as a regulator of circadian rhythms, both by regulating expression of clock-controlled genes involved in lipid and carbohydrate metabolism, and by catalyzing deacetylation of PER2 (PubMed:25083875, PubMed:30782483). The defatty-acylase activity is specifically involved in regulation of protein secretion (PubMed:19151729, PubMed:27322069). Has high activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as RRAS2 and TNF, thereby regulating their secretion (By similarity). Also acts as a mono-ADP-ribosyltransferase by mediating mono-ADP-ribosylation of PARP1, TRIM28/KAP1 or SMARCC2/BAF170 (PubMed:15795229, PubMed:21680843, PubMed:25247314, PubMed:31216030). Mono-ADP-ribosyltransferase activity is involved in DNA repair, cellular senescence, repression of LINE-1 retrotransposon elements and regulation of transcription (PubMed:21680843, PubMed:25247314, PubMed:30853213, PubMed:31216030, PubMed:32584788)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SIRT6 is a nuclear ADP-ribosyltransferase, [RefSeq, PubMed]; Suggests similarities in the molecular mechanisms by which SIRT6 and WRN may prevent premature aging-like phenotypes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.2.5;2.4.2.31;2.4.2.-;2.3.1.-;2.3.1.286;3.1.-.-", "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0097372 histone H3K18 deacetylase activity, NAD-dependent;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0000785 chromatin;GO:0035861 site of double-strand break", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:1904385 cellular response to angiotensin;GO:0031508 pericentric heterochromatin formation;GO:2000648 positive regulation of stem cell proliferation;GO:1902459 positive regulation of stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "P59941-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q505B8-1", "uniprot_id": "SYCE2_MOUSE", "mass": 19558.0, "length": 171, "protein_name": "Synaptonemal complex central element protein 2", "gene_name": "Syce2", "organism": "Mouse", "refseq_name": "synaptonemal complex central element protein 2 isoform 3", "refseq_ac": "NP_001161716", "gene_names_uniprotkb": "Syce2; Cesc1", "gene_names_refseq": "1700013H19Rik; Cesc1; Syce2", "protein_names_uniprotkb": "Synaptonemal complex central element protein 2; Central element synaptonemal complex protein 1", "protein_names_refseq": "central element synaptonemal complex 1; central element synaptonemal complex protein 1; synaptonemal complex central element protein 2 isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:71846)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15944401;16968740;17339376;21637789;21750661", "class_list": "", "function": "Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:15944401). Requires SYCP1 in order to be incorporated into the central element (PubMed:15944401, PubMed:16968740). May have a role in the synaptonemal complex assembly, stabilization and recombination (PubMed:15944401)., [UniProtKB, PubMed, PubMed]; Synaptonemal complex assembly is dependent on SYCE2., [RefSeq, PubMed]; The localisation of Syce1 and Cesc1 (Syce2) to the central element depends on recruitment by Sycp1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJR1;Q9DAC4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000801 central element;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0051301 cell division;GO:0007130 synaptonemal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q505B8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62296-1", "uniprot_id": "TEAD4_MOUSE", "mass": 48028.0, "length": 427, "protein_name": "Transcriptional enhancer factor TEF-3", "gene_name": "Tead4", "organism": "Mouse", "refseq_name": "transcriptional enhancer factor TEF-3 isoform b", "refseq_ac": "NP_001074448", "gene_names_uniprotkb": "Tead4; Tcf13r1; Tef3; Tefr1", "gene_names_refseq": "ETFR-2; Etfr2; FR-19; Rtef1; TEAD-4; TEF-3; Tcf13r1; Tead4; Tef3; Tefr1a; Tefr1; Tefr", "protein_names_uniprotkb": "Transcriptional enhancer factor TEF-3; ETF-related factor 2; ETFR-2; RTEF-1; TEA domain family member 4; TEAD-4; TEF-1-related factor 1; TEF-1-related factor FR-19", "protein_names_refseq": "ETF-related factor-2; FGF-regulated 19; RTEF-1; TEF-1-related factor 1; TEF-1-related factor FR-19; transcriptional enhancer factor TEF-3 isoform b; transcriptional enhancer factor TEF-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:21679); (R-MMU-2032785); (R-MMU-8951671)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "20123908;21750661;30084848;31219806;37169570;38206180;38789684;8631987;8662936;8702974;8920920", "class_list": "", "function": "TEAD4 regulates KRT8 and YAP in preimplantation embryos in mice but not in cattle. Publication Status: Online-Only, [RefSeq, PubMed]; TFAP2C exacerbates psoriasis-like inflammation by promoting Th17 and Th1 cells activation through regulating TEAD4 transcription. Publication Status: Online-Only, [RefSeq, PubMed]; Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification., [RefSeq, PubMed]; This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. This factor may play a role in the embryonic development of skeletal muscle. Alternatively spliced transcripts encoding distinct isoforms, which are translated through the use of a non-AUG (AUU) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2BDD5;P70282;Q61174;Q61175;Q62298", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0001708 cell fate specification;GO:1902459 positive regulation of stem cell population maintenance;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62296-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CUN6-1", "uniprot_id": "SMUF1_MOUSE", "mass": 83356.0, "length": 731, "protein_name": "E3 ubiquitin-protein ligase SMURF1", "gene_name": "Smurf1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase SMURF1 isoform 1", "refseq_ac": "NP_001033716", "gene_names_uniprotkb": "Smurf1", "gene_names_refseq": "4930431E10Rik; Smurf1; mKIAA1625", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SMURF1; 2.3.2.26; HECT-type E3 ubiquitin transferase SMURF1; SMAD ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1", "protein_names_refseq": "E3 ubiquitin-protein ligase SMURF1 isoform 1; E3 ubiquitin-protein ligase SMURF1; HECT-type E3 ubiquitin transferase SMURF1; Smad ubiquitination regulatory factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75788); (R-MMU-201451); (R-MMU-2173791); (R-MMU-4608870); (R-MMU-5632684); (R-MMU-8941858); (R-MMU-983168)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "10458166;12738770;21750661;23087404;24925320;27052174;31219806;31291647;35820727;37828378;37994046;38324299;39627609", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway (By similarity). Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Acts as a positive regulator of smoothened signaling pathway by mediating ubiquitination of PTCH1, leading to endocytosis and lysosomal degradation of PTCH1 (PubMed:24925320). Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation (By similarity). Plays a role in dendrite formation by melanocytes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Initial identification of Smurf1 as an ubiquitin ligase that inhibits BMP signaling by targeting Smad1/5 for proteasomal destruction in cultured cells and Xenopus embryos., [RefSeq, PubMed]; SMURF1 activates the cGAS/STING/IFN-1 signal axis by mediating YY1 ubiquitination to accelerate the progression of lupus nephritis., [RefSeq, PubMed]; Smurf1 Modulates Smad Signaling Pathway in Fibrotic Cataract Formation., [RefSeq, PubMed]; Smurf1 appears to be an important regulatory factor in osteoblast differentiation and a potential molecular target for identification of bone anabolic agents, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U412;Q8K300", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.1.48;2.3.1.-;2.3.2.-;3.6.4.-;2.7.11.30;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.13;2.7.11.1;2.3.2.36;2.3.2.25;6.2.1.-;3.6.5.2", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0005160 transforming growth factor beta receptor binding;GO:0046332 SMAD binding;GO:0004842 ubiquitin-protein transferase activity;GO:0070412 R-SMAD binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030154 cell differentiation;GO:0051607 defense response to virus;GO:0072659 protein localization to plasma membrane;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9CUN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2Y9-1", "uniprot_id": "SOSB1_MOUSE", "mass": 22628.0, "length": 212, "protein_name": "SOSS complex subunit B1", "gene_name": "Nabp2", "organism": "Mouse", "refseq_name": "SOSS complex subunit B1 isoform 1", "refseq_ac": "NP_081533", "gene_names_uniprotkb": "Nabp2; Obfc2b; Ssb1", "gene_names_refseq": "2610036N15Rik; Nabp2; Obfc2b; SSB1", "protein_names_uniprotkb": "SOSS complex subunit B1; Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; SOSS-B1; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; Single-stranded DNA-binding protein 1", "protein_names_refseq": "SOSS complex subunit B1 isoform 1; SOSS complex subunit B1; SOSS-B1; oligonucleotide/oligosaccharide-binding fold containing 2B; oligonucleotide/oligosaccharide-binding fold-containing protein 2B; sensor of single-strand DNA complex subunit B1; sensor of ssDNA subunit B1; single-stranded DNA-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69917); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16533169;21750661;22940690;26495903", "class_list": "", "function": "Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Obfc2b deficiency does not affect initiation of DNA damage checkpoints, Atm activation, or the maintenance of genomic stability in B lymphocytes & primary fibroblasts. Its role in embryogenesis limited to cell types contributing to bone formation. Erratum:[EMBO J. 2021 Jan 15;40(2):e107130. doi: 10.15252/embj.2020107130. PMID: 33448440], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0098505 G-rich strand telomeric DNA binding;GO:0003677 DNA binding;GO:0070182 DNA polymerase binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0070200 establishment of protein localization to telomere;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R2Y9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JM73-1", "uniprot_id": "SRF_MOUSE", "mass": 51247.0, "length": 504, "protein_name": "Serum response factor", "gene_name": "Srf", "organism": "Mouse", "refseq_name": "serum response factor", "refseq_ac": "NP_065239", "gene_names_uniprotkb": "Srf", "gene_names_refseq": "Srf", "protein_names_uniprotkb": "Serum response factor; SRF", "protein_names_refseq": "serum response factor", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); dilated cardiomyopathy (Disease Ontology:DOID:12930); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:20807); (R-MMU-5663220); (R-MMU-9031628)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "12732141;12809504;15169892;15492011;16537394;16597624;16782067;16814806;17242355;19131326;19350017;21183079;21750661;24732378;31219806;31599954;33743134;34547820", "class_list": "", "function": "SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS) (PubMed:24732378). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12732141, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). Required for cardiac differentiation and maturation (PubMed:15169892)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0010736 serum response element binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0030878 thyroid gland development;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0046016 positive regulation of transcription by glucose;GO:0060379 cardiac muscle cell myoblast differentiation;GO:0060534 trachea cartilage development", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q9JM73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCZ3-1", "uniprot_id": "THAP7_MOUSE", "mass": 34593.0, "length": 309, "protein_name": "THAP domain-containing protein 7", "gene_name": "Thap7", "organism": "Mouse", "refseq_name": "THAP domain-containing protein 7", "refseq_ac": "NP_081185", "gene_names_uniprotkb": "Thap7", "gene_names_refseq": "1810004B07Rik; Thap7", "protein_names_uniprotkb": "THAP domain-containing protein 7", "protein_names_refseq": "THAP domain-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:69009)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042826 histone deacetylase binding;GO:0140296 general transcription initiation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0031965 nuclear membrane;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VCZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYZ3-1", "uniprot_id": "SMK2B_MOUSE", "mass": 54698.0, "length": 484, "protein_name": "Sperm motility kinase 2B", "gene_name": "Smok2b", "organism": "Mouse", "refseq_name": "sperm motility kinase 2B", "refseq_ac": "NP_001161385", "gene_names_uniprotkb": "Smok2b; Gm1847", "gene_names_refseq": "Gm1847; Smok+129; Smok2b", "protein_names_uniprotkb": "Sperm motility kinase 2B; 2.7.11.1", "protein_names_refseq": "sperm motility kinase 2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:236574)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10647005;34418053", "class_list": "", "function": "May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QYZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70318-1", "uniprot_id": "TIAR_MOUSE", "mass": 43389.0, "length": 392, "protein_name": "Nucleolysin TIAR", "gene_name": "Tial1", "organism": "Mouse", "refseq_name": "nucleolysin TIAR isoform 1", "refseq_ac": "NP_033409", "gene_names_uniprotkb": "Tial1", "gene_names_refseq": "5330433G13Rik; TIAR; Tial1; mTIAR", "protein_names_uniprotkb": "Nucleolysin TIAR; TIA-1-related protein", "protein_names_refseq": "TIA-1-related protein; Tial1 cytotoxic granule-associated RNA binding protein-like 1; nucleolysin TIAR isoform 1; nucleolysin TIAR", "tax_id": 10090, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:21843)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11514562;16278295;17488725;19861488;21750661;34428180;37474714;40684658;40997131;8871565", "class_list": "", "function": "RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (By similarity). Shows a preference for uridine-rich RNAs (By similarity). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (PubMed:11514562). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725). Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (By similarity). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (By similarity). May be involved in apoptosis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA translation to protect germinal center responses from apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0140517 protein-RNA adaptor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0007281 germ cell development;GO:2000637 positive regulation of miRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P70318-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAQ9-1", "uniprot_id": "SPT19_MOUSE", "mass": 18057.0, "length": 154, "protein_name": "Spermatogenesis-associated protein 19, mitochondrial", "gene_name": "Spata19", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 19, mitochondrial isoform 2", "refseq_ac": "NP_001291987", "gene_names_uniprotkb": "Spata19; Spergen1", "gene_names_refseq": "1700001L23Rik; Spata19; spergen-1", "protein_names_uniprotkb": "Spermatogenesis-associated protein 19, mitochondrial; Spergen-1; Spermatogenic cell-specific gene 1 protein", "protein_names_refseq": "spermatogenesis-associated protein 19, mitochondrial isoform 2; spermatogenesis-associated protein 19, mitochondrial; spermatogenic cell-specific gene 1 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:75469)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15139970;21750661;26265198", "class_list": "", "function": "Essential for sperm motility and male fertility (PubMed:26265198). Plays an important role in sperm motility by regulating the organization and function of the mitochondria and is also required for correct sperm midpiece assembly (PubMed:26265198)., [UniProtKB, PubMed]; Findings suggest that SPATA19 plays an important role in sperm motility by regulating the organization and function of the mitochondria., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810M9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0036126 sperm flagellum;GO:0097225 sperm midpiece", "go_biological_process": "GO:0030382 sperm mitochondrion organization;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DAQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VD33-1", "uniprot_id": "SGTB_MOUSE", "mass": 33429.0, "length": 304, "protein_name": "Small glutamine-rich tetratricopeptide repeat-containing protein beta", "gene_name": "Sgtb", "organism": "Mouse", "refseq_name": "small glutamine-rich tetratricopeptide repeat-containing protein beta", "refseq_ac": "NP_659087", "gene_names_uniprotkb": "Sgtb", "gene_names_refseq": "C630001O05Rik; Sgtb", "protein_names_uniprotkb": "Small glutamine-rich tetratricopeptide repeat-containing protein beta; Beta-SGT", "protein_names_refseq": "beta-SGT; small glutamine-rich tetratricopeptide repeat-containing protein beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:218544)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30639199", "class_list": "", "function": "Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity., [UniProtKB]; The data suggest that SGTb interacts with BOC (brother of CDO protein) and regulates its surface level and consequent JNK activation, thereby promoting neuronal differentiation and neurite outgrowth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0016020 membrane;GO:0072380 TRC complex", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VD33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62445-1", "uniprot_id": "SP4_MOUSE", "mass": 81906.0, "length": 782, "protein_name": "Transcription factor Sp4", "gene_name": "Sp4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sp4", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor Sp4", "protein_names_refseq": "", "tax_id": 10090, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); congenital heart disease (Disease Ontology:DOID:1682); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:20688)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;30084848;32152506;34428180;40885482;8660867", "class_list": "", "function": "Binds to GT and GC boxes promoters elements. Probable transcriptional activator. Required for normal male reproductive behavior., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QNI3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008016 regulation of heart contraction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q62445-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UHD6-1", "uniprot_id": "SNX27_MOUSE", "mass": 60989.0, "length": 539, "protein_name": "Sorting nexin-27", "gene_name": "Snx27", "organism": "Mouse", "refseq_name": "sorting nexin-27 isoform 1", "refseq_ac": "NP_001075953", "gene_names_uniprotkb": "Snx27; Kiaa0488", "gene_names_refseq": "5730552M22Rik; ESTM45; ESTM47; Snx27", "protein_names_uniprotkb": "Sorting nexin-27", "protein_names_refseq": "sorting nexin-27 isoform 1; sorting nexin-27", "tax_id": 10090, "disease": "", "pathway": " (mmu:76742)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;15466885;17114649;17351151;21183079;21300787;21750661;23524343;28135057;30084848;34002021;34428180;37507081", "class_list": "", "function": "Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes., [UniProtKB, PubMed]; Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation., [RefSeq, PubMed]; SNX27 and NHERF specifically interact with the 5-HT4a receptor splice variant, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQL6;Q80TZ1;Q9CYB5", "ec_number_list": "", "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098837 postsynaptic recycling endosome;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:1903609 negative regulation of inward rectifier potassium channel activity;GO:0006886 intracellular protein transport;GO:0007165 signal transduction;GO:0008333 endosome to lysosome transport;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3UHD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CY50-1", "uniprot_id": "SSRA_MOUSE", "mass": 32065.0, "length": 286, "protein_name": "Translocon-associated protein subunit alpha", "gene_name": "Ssr1", "organism": "Mouse", "refseq_name": "translocon-associated protein subunit alpha isoform 1 precursor", "refseq_ac": "NP_080241", "gene_names_uniprotkb": "Ssr1", "gene_names_refseq": "2510001K09Rik; 6330400D04; SSR; Ssr1; TRAPA", "protein_names_uniprotkb": "Translocon-associated protein subunit alpha; SSR-alpha; Signal sequence receptor subunit alpha; TRAP-alpha", "protein_names_refseq": "SSR-alpha; TRAP-alpha; signal sequence receptor subunit alpha; translocon-associated protein alpha; translocon-associated protein subunit alpha isoform 1 precursor; translocon-associated protein subunit alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:107513)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;17015483;18250455;18630941;19131326;19144319;19656770;20173027;21183079;21750661;25428506;25605945;30084848;30899004;34428180;37828378;40997131", "class_list": "", "function": "TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TRAPalpha could be involved in translocation of factors necessary for maturation of endocardial cushions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIM3;Q99MP2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q9CY50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MW1-1", "uniprot_id": "STK31_MOUSE", "mass": 115018.0, "length": 1018, "protein_name": "Serine/threonine-protein kinase 31", "gene_name": "Stk31", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase 31 isoform 1", "refseq_ac": "NP_084192", "gene_names_uniprotkb": "Stk31", "gene_names_refseq": "C330007K24Rik; Stk31", "protein_names_uniprotkb": "Serine/threonine-protein kinase 31; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase 31 isoform 1; serine/threonine-protein kinase 31", "tax_id": 10090, "disease": "", "pathway": " (mmu:77485)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11279525;21750661;22205278;23929668;24586802", "class_list": "", "function": "Our findings suggest mouse STK31 could be a potential nuage-associated protein in the cytoplasm of mid-to-late spermatocytes and play pivotal roles related to fertilization., [RefSeq, PubMed]; Stk31 is dispensable for both embryonic development and spermatogenesis in mice., [RefSeq, PubMed]; The function of STK31 may be redundant with other Tdrd proteins in germ cell development. GeneRIF: STK31 is expressed in embryonic gonocytes of both sexes and postnatal spermatocytes and round spermatids in males. Disruption of the tudor domain and kinase domain of STK31 respectively does not affect fertility in mice. Our data suggest that the function of STK31 may be redundant with other Tdrd proteins in germ cell development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQM2;E9QLI8", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99MW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59096-1", "uniprot_id": "STAR6_MOUSE", "mass": 26223.0, "length": 233, "protein_name": "StAR-related lipid transfer protein 6", "gene_name": "Stard6", "organism": "Mouse", "refseq_name": "stAR-related lipid transfer protein 6", "refseq_ac": "NP_001276577", "gene_names_uniprotkb": "Stard6", "gene_names_refseq": "1700011K09Rik; 4833424I06Rik; 4933429L05Rik; Stard6", "protein_names_uniprotkb": "StAR-related lipid transfer protein 6; START domain-containing protein 6; StARD6", "protein_names_refseq": "START domain containing protein 6; StAR-related lipid transfer (START) domain containing 6; stAR-related lipid transfer protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:170461); (R-MMU-196108)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12011452;18211099;21750661", "class_list": "", "function": "May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; StARD6, which is expressed only in male germ-line cells, thus exhibits biological and biophysical properties that imply a role in steroidogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0008289 lipid binding", "go_cellular_component": "", "go_biological_process": "GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P59096-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99M96-1", "uniprot_id": "ST7_MOUSE", "mass": 66095.0, "length": 577, "protein_name": "Suppressor of tumorigenicity 7 protein", "gene_name": "St7", "organism": "Mouse", "refseq_name": "suppressor of tumorigenicity 7 protein isoform 2", "refseq_ac": "NP_001076784", "gene_names_uniprotkb": "St7", "gene_names_refseq": "9430001H04Rik; Fam4a2; HELG; RAY1; SEN4; St7; TSG7", "protein_names_uniprotkb": "Suppressor of tumorigenicity 7 protein; mRay", "protein_names_refseq": "4low density lipoprotein-related protein 12; family with sequence similarity 4, subfamily A, member 2; suppressor of tumorigenicity 7 protein isoform 2; suppressor of tumorigenicity 7 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:64213)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10889047;11279520;15485929;15592501;21750661;25605945;26495903;31219806;34428180", "class_list": "", "function": "Suppressor of tumorigenicity 7 (ST7) and nonmetastatic 23 (NM23) are direct targets of PRMT5-containing BRG1 and hBRM complexes, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UA20;Q6Q9W2;Q6Q9W3;Q8R3T3;Q921F6;Q99M89;Q99M90;Q99M91;Q99M92;Q99M93;Q99M94;Q9JID7;Q9JID8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99M96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88816-1", "uniprot_id": "SNAT_MOUSE", "mass": 23069.0, "length": 205, "protein_name": "Serotonin N-acetyltransferase", "gene_name": "Aanat", "organism": "Mouse", "refseq_name": "serotonin N-acetyltransferase", "refseq_ac": "NP_033721", "gene_names_uniprotkb": "Aanat; Snat", "gene_names_refseq": "AA-NAT; Aanat; Nat-2; Nat4; Snat", "protein_names_uniprotkb": "Serotonin N-acetyltransferase; 2.3.1.87; AA-NAT; Aralkylamine N-acetyltransferase; Serotonin acetylase", "protein_names_refseq": "aralkylamine N-acetyltransferase; serotonin N-acetyltransferase; serotonin acetylase", "tax_id": 10090, "disease": "advanced sleep phase syndrome (Disease Ontology:DOID:0050628); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:11298); (R-MMU-209931)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20308563;21750661;9708862;9838107", "class_list": "", "function": "Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin., [UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.87", "go_molecular_function": "GO:0071889 14-3-3 protein binding;GO:0004060 arylamine N-acetyltransferase activity;GO:0004059 aralkylamine N-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0010043 response to zinc ion;GO:0051592 response to calcium ion;GO:0071320 cellular response to cAMP;GO:0007623 circadian rhythm;GO:0032868 response to insulin", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88816-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PDF3-1", "uniprot_id": "SVOPL_MOUSE", "mass": 54461.0, "length": 494, "protein_name": "Putative transporter SVOPL", "gene_name": "Svopl", "organism": "Mouse", "refseq_name": "putative transporter SVOPL", "refseq_ac": "NP_796174", "gene_names_uniprotkb": "Svopl", "gene_names_refseq": "9430071P14Rik; Svopl", "protein_names_uniprotkb": "Putative transporter SVOPL; SVOP-like protein", "protein_names_refseq": "SVOP-like protein; putative transporter SVOPL", "tax_id": 10090, "disease": "", "pathway": " (mmu:320590)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "glycogene", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BM44", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PDF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIE0-1", "uniprot_id": "SPA11_MOUSE", "mass": 47188.0, "length": 424, "protein_name": "Serpin A11", "gene_name": "Serpina11", "organism": "Mouse", "refseq_name": "serpin A11 isoform 1 precursor", "refseq_ac": "NP_955018", "gene_names_uniprotkb": "Serpina11; Gm895", "gene_names_refseq": "Gm895; Serpina11", "protein_names_uniprotkb": "Serpin A11", "protein_names_refseq": "serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11; serine (or cysteine) proteinase inhibitor, clade A, member 11; serpin A11 isoform 1 precursor; serpin A11", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831)", "pathway": " (mmu:380780)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;38831697", "class_list": "", "function": "SERPINA11 related novel serpinopathy - A perinatal lethal disorder., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CIE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBQ9-1", "uniprot_id": "SWT1_MOUSE", "mass": 103168.0, "length": 907, "protein_name": "Transcriptional protein SWT1", "gene_name": "Swt1", "organism": "Mouse", "refseq_name": "transcriptional protein SWT1", "refseq_ac": "NP_080095", "gene_names_uniprotkb": "Swt1; 1200016B10Rik", "gene_names_refseq": "1200016B10Rik; C1orf26; Swt1", "protein_names_uniprotkb": "Transcriptional protein SWT1", "protein_names_refseq": "transcriptional protein SWT1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66875)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25605945;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QP79;Q6PAN2;Q7TMQ6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DBQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWR2-1", "uniprot_id": "SMYD3_MOUSE", "mass": 49126.0, "length": 428, "protein_name": "Histone-lysine N-methyltransferase SMYD3", "gene_name": "Smyd3", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase SMYD3", "refseq_ac": "NP_081464", "gene_names_uniprotkb": "Smyd3; Zmynd1", "gene_names_refseq": "2410008A19Rik; Smyd3; Zmynd1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SMYD3; 2.1.1.354; SET and MYND domain-containing protein 3; Zinc finger MYND domain-containing protein 1", "protein_names_refseq": "SET and MYND domain-containing protein 3; histone-lysine N-methyltransferase SMYD3; zinc finger MYND domain-containing protein 1; zinc finger, MYND domain containing 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69726); (R-MMU-3214841)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15235609;21750661;25428506;34428180;36609445;38148333", "class_list": "", "function": "Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Lys-5' of histone H4. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences., [UniProtKB, UniProtKB]; Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model. Publication Status: Online-Only, [RefSeq, PubMed]; SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells., [RefSeq, PubMed]; SMYD3: a new regulator of adipocyte precursor proliferation at the early steps of differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7V6;Q8BG90", "ec_number_list": "2.1.1.364;2.1.1.-;2.1.1.354;2.1.1.362;2.1.1.361;2.1.1.370;2.1.1.371;2.1.1.85;2.1.1.359;2.1.1.355", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000993 RNA polymerase II complex binding;GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding;GO:0140954 histone H3K36 dimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0014904 myotube cell development;GO:0007507 heart development;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CWR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63058-1", "uniprot_id": "THA_MOUSE", "mass": 55023.0, "length": 492, "protein_name": "Thyroid hormone receptor alpha", "gene_name": "Thra", "organism": "Mouse", "refseq_name": "thyroid hormone receptor alpha isoform 1", "refseq_ac": "NP_001300912", "gene_names_uniprotkb": "Thra; C-erba-alpha; Nr1a1", "gene_names_refseq": "6430529J03Rik; Erba; Nr1a1; Rvr; T3R[a]; T3Ralpha; Thra1; Thra2; Thra; c-erbA-1; c-erbA-alpha; c-erbAalpha", "protein_names_uniprotkb": "Thyroid hormone receptor alpha; Nuclear receptor subfamily 1 group A member 1; c-erbA-1; c-erbA-alpha", "protein_names_refseq": "TR alpha 1; TR alpha 2; nuclear receptor subfamily 1 group A member 1; thyroid hormone receptor alpha isoform 1", "tax_id": 10090, "disease": "congenital nongoitrous hypothyroidism 6 (Disease Ontology:DOID:0070128); thyroid hormone resistance syndrome (Disease Ontology:DOID:11633); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:21833); (R-MMU-383280); (R-MMU-4090294)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10681503;16322094;20078863;20159955;21750661;2349106;31219806;3399404;38889231;9405624", "class_list": "", "function": "Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRalpha and TRbeta., [RefSeq, PubMed]; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-deltaE6 does not bind DNA, inhibits the activity of isoform Alpha-1, and stimulates myoblast differentiation., [UniProtKB, PubMed]; The protein encoded by this gene is one of several nuclear hormone receptors that bind thyroid hormones such as triiodothyronine and thyroxine with high affinity. The encoded protein is a transcription factor that can activate or repress transcription. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KFN4;P10685;P15827;P16416;P37241;Q542U8;Q63107;Q63195;Q63196;Q80Y90;Q99146", "ec_number_list": "", "go_molecular_function": "GO:0002153 steroid receptor RNA activator RNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0030878 thyroid gland development;GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0033032 regulation of myeloid cell apoptotic process;GO:0002155 regulation of thyroid hormone receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P63058-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CJ67-1", "uniprot_id": "STAU2_MOUSE", "mass": 62535.0, "length": 570, "protein_name": "Double-stranded RNA-binding protein Staufen homolog 2", "gene_name": "Stau2", "organism": "Mouse", "refseq_name": "double-stranded RNA-binding protein Staufen homolog 2 isoform 2", "refseq_ac": "NP_001104742", "gene_names_uniprotkb": "Stau2", "gene_names_refseq": "Stau2", "protein_names_uniprotkb": "Double-stranded RNA-binding protein Staufen homolog 2", "protein_names_refseq": "double-stranded RNA-binding protein Staufen homolog 2 isoform 2; double-stranded RNA-binding protein Staufen homolog 2; staufen (RNA binding protein) homolog 2; staufen 2", "tax_id": 10090, "disease": "microphthalmia (Disease Ontology:DOID:10629)", "pathway": " (mmu:29819)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12140260;12859680;15166236;21750661;22645316;24788674;25428506;30084848;32848054;34345913;34418053;34678516;37439148", "class_list": "", "function": "Data show that Stau2 is localized to the neuronal soma and dendrites, but it does not colocalize with Stau1-containing particles., [RefSeq, PubMed]; RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RNF216 affects the stability of STAU2 in the hypothalamus., [RefSeq, PubMed]; STAU2 binds a complex RNA cargo that changes temporally with production of diverse intermediate progenitor cells during mouse corticogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSY8;Q8CJ66;Q8R175;Q91Z19;Q9D5N7", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0051019 mitogen-activated protein kinase binding;GO:0003725 double-stranded RNA binding;GO:0019894 kinesin binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0034599 cellular response to oxidative stress;GO:0051965 positive regulation of synapse assembly;GO:0007281 germ cell development;GO:0051489 regulation of filopodium assembly", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q8CJ67-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70297-1", "uniprot_id": "STAM1_MOUSE", "mass": 59771.0, "length": 548, "protein_name": "Signal transducing adapter molecule 1", "gene_name": "Stam", "organism": "Mouse", "refseq_name": "signal transducing adapter molecule 1 isoform 1", "refseq_ac": "NP_035614", "gene_names_uniprotkb": "Stam; Stam1", "gene_names_refseq": "STAM1; Stam", "protein_names_uniprotkb": "Signal transducing adapter molecule 1; STAM-1", "protein_names_refseq": "STAM-1; signal transducing adapter molecule 1 isoform 1; signal transducing adapter molecule 1", "tax_id": 10090, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322)", "pathway": " (mmu:20844); (R-MMU-182971); (R-MMU-5689901); (R-MMU-6807004); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9013420); (R-MMU-917729)", "pathway_count": 8, "publication_count": 13, "publication_id_list": "11340172;12446783;15640163;19278655;21750661;25296754;25605945;26495903;27161150;31219806;34428180;34678516;8780729", "class_list": "", "function": "ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation. Erratum:[J Biol Chem. 2015 Mar 27;290(13):8065-6. doi: 10.1074/jbc.A114.578245. PMID: 25819836], [RefSeq, PubMed]; Hrs is a master molecule that controls in part the degradation of STAM1 and the accumulation of ubiquitinated proteins, [RefSeq, PubMed]; Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity)., [UniProtKB]; The motor neuron-specific ISL1-LHX3 complex directly transactivates the Stam1 gene., [RefSeq, PubMed]; These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding;GO:0044389 ubiquitin-like protein ligase binding", "go_cellular_component": "GO:0033565 ESCRT-0 complex;GO:0005829 cytosol;GO:0031901 early endosome membrane", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0016236 macroautophagy;GO:1903543 positive regulation of exosomal secretion;GO:1903551 regulation of extracellular exosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P70297-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZH1-1", "uniprot_id": "TGM4_MOUSE", "mass": 75591.0, "length": 670, "protein_name": "Protein-glutamine gamma-glutamyltransferase 4", "gene_name": "Tgm4", "organism": "Mouse", "refseq_name": "protein-glutamine gamma-glutamyltransferase 4", "refseq_ac": "NP_808579", "gene_names_uniprotkb": "Tgm4; Eapa1", "gene_names_refseq": "9530008N10Rik; Eapa1; TGP; Tgm4", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase 4; 2.3.2.13; Experimental autoimmune prostatitis antigen 1; TGase-4; Transglutaminase-4", "protein_names_refseq": "TGase-4; experimental autoimmune prostatitis antigen 1; protein-glutamine gamma-glutamyltransferase 4; transglutaminase-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:331046)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;16223778;19027372;19452452;21750661;22307675;23341775;25428506;26084804;30779550", "class_list": "", "function": "Associated with the mammalian reproductive process. Plays an important role in the formation of the seminal coagulum through the cross-linking of specific proteins present in the seminal plasma. Transglutaminase is also required to stabilize the copulatory plug., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Male mice knockouts for transglutaminase IV (Tgm4) fail to form a copulatory plug, demonstrating that this gene is necessary for plug formation and lending a powerful new genetic tool to begin characterizing plug function, [RefSeq, PubMed]; TGM4 is a prostatic secretory molecule with critical role in male reproduction., [RefSeq, PubMed]; The androgen-dependent SVS I is exclusively expressed in the luminal epithelium of seminal vesicle; Gln232 and Gln254 are the major TG4-reactive residues on SVS I and and TG4 is much stronger than TG2 to cross-link the glutamine residues in SVS I., [RefSeq, PubMed]; These studies demonstrate that tranglutaminase 2 independent activity exists in the vasculature and that Tgm1 and tgm4 are expressed in vascular tissues, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B7ZP44;Q8K460", "ec_number_list": "3.4.-.-;2.3.1.-;2.3.2.13;3.5.1.44", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix", "go_biological_process": "GO:0018149 peptide cross-linking;GO:0042628 mating plug formation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BZH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TD49-1", "uniprot_id": "SPP2B_MOUSE", "mass": 63824.0, "length": 578, "protein_name": "Signal peptide peptidase-like 2B", "gene_name": "Sppl2b", "organism": "Mouse", "refseq_name": "signal peptide peptidase-like 2B isoform 1 precursor", "refseq_ac": "NP_780404", "gene_names_uniprotkb": "Sppl2b", "gene_names_refseq": "3110056O03Rik; PSL1; Sppl2b", "protein_names_uniprotkb": "Signal peptide peptidase-like 2B; 3.4.23.-; SPP-like 2B; SPPL2b", "protein_names_refseq": "protein SPP-like 2B; protein SPPL2b; signal peptide peptidase-like 2B isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:73218); (R-MMU-5357905)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;21896273;24492962;30819724;31219806;33300544;34887587;36047592;38367747", "class_list": "", "function": "In vivo SPPL2a, but not SPPL2b, exhibit a physiologically relevant contribution to CD74 proteolysis in B and dendritic cells, [RefSeq, PubMed]; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity., [UniProtKB, UniProtKB]; SPPL2a/b negatively regulates LOX-1 signaling and atherosclerosis., [RefSeq, PubMed]; Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Abeta-dependent expression in Alzheimer's disease., [RefSeq, PubMed]; The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLQ8;Q3UG60;Q80VZ6", "ec_number_list": "3.4.23.-", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0050776 regulation of immune response;GO:0031293 membrane protein intracellular domain proteolysis;GO:0033619 membrane protein proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3TD49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C9H6-1", "uniprot_id": "STRP2_MOUSE", "mass": 96294.0, "length": 844, "protein_name": "Striatin-interacting proteins 2", "gene_name": "Strip2", "organism": "Mouse", "refseq_name": "striatin-interacting proteins 2 isoform b", "refseq_ac": "NP_001032829", "gene_names_uniprotkb": "Strip2; Fam40b; Kiaa1170; Stripb", "gene_names_refseq": "D330017J20Rik; Fam40b; Myoscape; Strip2", "protein_names_uniprotkb": "Striatin-interacting proteins 2; Protein FAM40B", "protein_names_refseq": "family with sequence similarity 40, member B; protein FAM40B; striatin-interacting proteins 2 isoform b; striatin-interacting proteins 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:320609)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18782753;21183079;21750661;25010986;27122098;34428180;36210013", "class_list": "", "function": "Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Required in the regulation of cell morphology and cytoskeletal organization., [UniProtKB, UniProtKB]; Fam40b is essential for the lineage commitment of murine embryonic stem cells into differentiated somatic cells. Publication Status: Online-Only, [RefSeq, PubMed]; Myoscape/FAM40B/STRIP2 knockout (KO) mice display impairment of cardiac function progressing to advanced heart failure. Erratum:[Nat Commun. 2016 May 26;7:11835. doi: 10.1038/ncomms11835. PMID: 27225593] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQB7;Q80TI6;Q8C7A2", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0090443 FAR/SIN/STRIPAK complex", "go_biological_process": "GO:0016477 cell migration;GO:0007010 cytoskeleton organization;GO:0008360 regulation of cell shape;GO:0035331 negative regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C9H6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55101-1", "uniprot_id": "SNG2_MOUSE", "mass": 24778.0, "length": 224, "protein_name": "Synaptogyrin-2", "gene_name": "Syngr2", "organism": "Mouse", "refseq_name": "synaptogyrin-2", "refseq_ac": "NP_033330", "gene_names_uniprotkb": "Syngr2", "gene_names_refseq": "Clast2; Syngr2; cellugyrin", "protein_names_uniprotkb": "Synaptogyrin-2; Cellugyrin", "protein_names_refseq": "synaptogyrin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20973)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12928441;18250455;21750661;26495903;34428180;35984892;9760194", "class_list": "", "function": "Cellugyrin and synaptogyrin have roles in facilitating targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment, [RefSeq, PubMed]; May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCK2;Q8C225;Q99K83", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0031594 neuromuscular junction;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0045055 regulated exocytosis;GO:0006605 protein targeting;GO:0048499 synaptic vesicle membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O55101-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P58404-1", "uniprot_id": "STRN4_MOUSE", "mass": 81645.0, "length": 760, "protein_name": "Striatin-4", "gene_name": "Strn4", "organism": "Mouse", "refseq_name": "striatin-4 isoform 2", "refseq_ac": "NP_001034967", "gene_names_uniprotkb": "Strn4; Zin", "gene_names_refseq": "Strn4; ZIN; zinedin", "protein_names_uniprotkb": "Striatin-4; Zinedin", "protein_names_refseq": "striatin-4 isoform 2; striatin-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:97387)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10748158;15345747;17242355;21183079;21750661;26495903;31219806;34428180", "class_list": "", "function": "Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QKX6;Q68EF5", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding;GO:0051721 protein phosphatase 2A binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0035331 negative regulation of hippo signaling;GO:0099159 regulation of modification of postsynaptic structure", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P58404-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80WV7-1", "uniprot_id": "SRRM3_MOUSE", "mass": 71104.0, "length": 648, "protein_name": "Serine/arginine repetitive matrix protein 3", "gene_name": "Srrm3", "organism": "Mouse", "refseq_name": "serine/arginine repetitive matrix protein 3", "refseq_ac": "NP_067378", "gene_names_uniprotkb": "Srrm3; MNCb-4760", "gene_names_refseq": "2900083I11Rik; SRm300-like; Srrm2l; Srrm3", "protein_names_uniprotkb": "Serine/arginine repetitive matrix protein 3", "protein_names_refseq": "serine/arginine repetitive matrix protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:58212)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;30602030;30995482;33087486;35858306;36759540", "class_list": "", "function": "Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse. Publication Status: Online-Only, [RefSeq, PubMed]; RNA splicing factor that regulates the inclusion of microexons in mRNA transcripts (PubMed:30995482, PubMed:36759540, PubMed:30602030). Required for motor coordination. In cortical neurons, acts redundantly with SRRM4 and regulates many alternative splicing events, including inclusion of exon 4 into the transcriptional repressor REST transcript, leading to REST inactivation. REST inactivation de-represses potassium-chloride cotransporter 2/SLC12A5 expression, resulting in the switch in GABAergic neurotransmission from immature excitatory to inhibitory (PubMed:30995482). Regulates inclusion of a microexon in TBC1D24 in the brain cortex (PubMed:30602030). In pancreatic islets, mediates microexon inclusion and regulates glucose- or amino acid-stimulated insulin secretion, as well as glucagon secretion (PubMed:36759540). Important for islet morphogenesis during pancreas development (PubMed:36759540). Regulates microexon inclusion in the developing retina, which is required for outer segment maintenance and vision (PubMed:35858306)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CUV5;Q9JJ91", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0046676 negative regulation of insulin secretion;GO:0008380 RNA splicing;GO:0070093 negative regulation of glucagon secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80WV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4N2-1", "uniprot_id": "SG11A_MOUSE", "mass": 8116.0, "length": 71, "protein_name": "Sperm-associated antigen 11A", "gene_name": "Gm45826; Spag11a", "organism": "Mouse", "refseq_name": "sperm-associated antigen 11A precursor", "refseq_ac": "NP_694755", "gene_names_uniprotkb": "Gm45826; Spag11a; Bin1b; Ep2e; Ep2; Spag11", "gene_names_refseq": "9230111C08Rik; Bin1b; EP2Q; EP2e; Spag11a; Spag11", "protein_names_uniprotkb": "Sperm-associated antigen 11A; Antimicrobial-like protein Bin-1b; EP2 protein", "protein_names_refseq": "EP2 protein; antimicrobial peptide Bin1b; antimicrobial-like protein Bin-1b; beta defensin EP2e; sperm-associated antigen 11A precursor; sperm-associated antigen 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:78128)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12193721;21199063;21750661;22535201;23815807;25428506", "class_list": "", "function": "Data suggest that Spag11a has a specific role in epididymal sperm maturation. Publication Status: Online-Only, [RefSeq, PubMed]; Has antimicrobial activity against E.coli (By similarity). Plays a role in the defense response in the male reproductive tract, contributing to sperm maturation, storage and protection (By similarity)., [UniProtKB, UniProtKB]; Increased expression in response to lipopolysaccharide administration, [RefSeq, PubMed]; Model was developed in which Bin1b was exclusively overexpressed by up to 50-fold in the caput epididymis. The transgenic mice are healthy with normal reproductive activity, but are more resistant to epididymal infection from E coli than normal animals., [RefSeq, PubMed]; The epididymis-specific expression pattern of the beta-defensin isoform EP2e has been characterized., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2HPE4;Q30KM3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0019732 antifungal humoral response;GO:0032691 negative regulation of interleukin-1 beta production;GO:0042742 defense response to bacterium;GO:0032690 negative regulation of interleukin-1 alpha production", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K4N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3D3-1", "uniprot_id": "SWI5_MOUSE", "mass": 10261.0, "length": 89, "protein_name": "DNA repair protein SWI5 homolog", "gene_name": "Swi5", "organism": "Mouse", "refseq_name": "DNA repair protein SWI5 homolog isoform a", "refseq_ac": "NP_001277481", "gene_names_uniprotkb": "Swi5; Sae3", "gene_names_refseq": "1500019F05Rik; 2900010J23Rik; Swi5", "protein_names_uniprotkb": "DNA repair protein SWI5 homolog; Protein SAE3 homolog", "protein_names_refseq": "DNA repair protein SWI5 homolog isoform a; DNA repair protein SWI5 homolog; protein SAE3 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:72931)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20976249;21750661;22492707;27131790;30297419;34428180", "class_list": "", "function": "Biophysical evidence that the mouse Swi5-Sfr1 complex has a 1:1 stoichiometry., [RefSeq, PubMed]; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Data show that Swi5-Sfr1 is a newly identified complex required for genomic integrity in mammalian cells with a specific role in the repair of DNA strand breaks. Publication Status: Online-Only, [RefSeq, PubMed]; Our results thus help establish the functional relevance of the trimeric RAD51-SWI5-SFR1 complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells., [RefSeq, PubMed]; Swi5-Sfr1 (S5S1) stimulates Rad51-mediated homologous recombination., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AN41", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0032798 Swi5-Sfr1 complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0071479 cellular response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K3D3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9I4-1", "uniprot_id": "TBC20_MOUSE", "mass": 45825.0, "length": 402, "protein_name": "TBC1 domain family member 20", "gene_name": "Tbc1d20", "organism": "Mouse", "refseq_name": "TBC1 domain family member 20", "refseq_ac": "NP_077158", "gene_names_uniprotkb": "Tbc1d20", "gene_names_refseq": "1110028I04Rik; 2810442O16Rik; Tbc1d20; bs", "protein_names_uniprotkb": "TBC1 domain family member 20", "protein_names_refseq": "TBC1 domain family member 20", "tax_id": 10090, "disease": "Warburg micro syndrome 4 (Disease Ontology:DOID:0110719)", "pathway": " (mmu:67231); (R-MMU-204005)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;24239381;26063829;27487390;31633178;31994000;34428180", "class_list": "", "function": "GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude (By similarity). Also shows GAP activity for RAB18 GTPase (PubMed:26063829). Promotes RAB18 dissociation from the endoplasmic reticulum (ER) membrane into the cytosol, probably through stimulating RAB18 GTP-hydrolysis (PubMed:26063829). Involved in maintaining endoplasmic reticulum structure (By similarity)., [UniProtKB, UniProtKB, PubMed]; It suggested that TBC1D20 deficiency triggers irreversible endoplasmic reticulum stress resulting in G1/S arrest and excessive apoptosis in TBC1D20-deficient Sertoli cells, and TBC1D20 deficiency in Sertoli cells may also contribute to the infertility phenotype in 'blind sterile' male mice., [RefSeq, PubMed]; TBC1D20 Is Essential for Mouse Blood-Testis Barrier Integrity Through Maintaining the Epithelial Phenotype and Modulating the Maturation of Sertoli Cells., [RefSeq, PubMed]; TBC1D20 has an essential role in the maturation of autophagosomes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TYW9;Q99LW2", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046726 positive regulation by virus of viral protein levels in host cell;GO:0044829 host-mediated activation of viral genome replication;GO:0090110 COPII-coated vesicle cargo loading;GO:0007283 spermatogenesis;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D9I4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPR5-1", "uniprot_id": "SORC2_MOUSE", "mass": 128902.0, "length": 1159, "protein_name": "VPS10 domain-containing receptor SorCS2", "gene_name": "Sorcs2", "organism": "Mouse", "refseq_name": "VPS10 domain-containing receptor SorCS2 precursor", "refseq_ac": "NP_112151", "gene_names_uniprotkb": "Sorcs2", "gene_names_refseq": "Sorcs2; mKIAA1329", "protein_names_uniprotkb": "VPS10 domain-containing receptor SorCS2", "protein_names_refseq": "VPS10 domain receptor protein SORCS 2; VPS10 domain-containing receptor SorCS2 precursor; VPS10 domain-containing receptor SorCS2", "tax_id": 10090, "disease": "", "pathway": " (mmu:81840)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11165493;15009648;19656770;21750661;22155786;22645316;24908487;27457814;28346477;28469074;29909994;30061605;30840898;30899004;31219806;33300544;37897724;38996926", "class_list": "", "function": "Hippocampal SorCS2 overexpression represses chronic stress-induced depressive-like behaviors by promoting the BDNF-TrkB system., [RefSeq, PubMed]; SorCS2 binds progranulin to regulate motor neuron development., [RefSeq, PubMed]; SorCS3 and the homologous sorCS1 and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 did not require protein synthesis, [RefSeq, PubMed]; The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487, PubMed:27457814, PubMed:29909994). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (PubMed:29909994). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814, PubMed:29909994). Plays a role in BDNF-dependent hippocampal synaptic plasticity (PubMed:27457814, PubMed:29909994). Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (By similarity). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes (PubMed:28469074). Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (PubMed:30840898)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "B2RSI2;B2RSI4", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0043197 dendritic spine", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0060292 long-term synaptic depression", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q9EPR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14576-1", "uniprot_id": "SRP54_MOUSE", "mass": 55721.0, "length": 504, "protein_name": "Signal recognition particle subunit SRP54", "gene_name": "Srp54a; Srp54", "organism": "Mouse", "refseq_name": "signal recognition particle 54 kDa protein isoform 1", "refseq_ac": "NP_036029", "gene_names_uniprotkb": "Srp54a; Srp54; Srp54b", "gene_names_refseq": "54kDa; Srp54a; Srp54", "protein_names_uniprotkb": "Signal recognition particle subunit SRP54; 3.6.5.4; Signal recognition particle 54 kDa protein", "protein_names_refseq": "54K subunit of signal recognition particle; signal recognition particle 54 kDa protein isoform 1; signal recognition particle 54 kDa protein; signal recognition particle subunit SRP54", "tax_id": 10090, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); severe congenital neutropenia 8 (Disease Ontology:DOID:0112135); neutropenia (Disease Ontology:DOID:1227)", "pathway": " (mmu:24067); (mmu:665155); (R-MMU-1799339)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "14985753;1702385;19224205;20173027;20485683;21750661;22645316;22872234;2502718;25428506;25605945;30084848;30779550;32152506;34203471;34428180;35820727;36210013", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UWX8;Q9CWH7;Q9D008", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;4.2.99.18;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0030942 endoplasmic reticulum signal peptide binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0048500 signal recognition particle", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0030593 neutrophil chemotaxis;GO:0031017 exocrine pancreas development;GO:0006614 SRP-dependent cotranslational protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P14576-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q571F5-1", "uniprot_id": "SPSB3_MOUSE", "mass": 39321.0, "length": 354, "protein_name": "SPRY domain-containing SOCS box protein 3", "gene_name": "Spsb3", "organism": "Mouse", "refseq_name": "SPRY domain-containing SOCS box protein 3 isoform a", "refseq_ac": "NP_001157222", "gene_names_uniprotkb": "Spsb3; Kiaa4204; Ssb3; Tce1", "gene_names_refseq": "2310012N15Rik; 3300001M01Rik; SSB3; Spsb3; Tce1; mKIAA4204", "protein_names_uniprotkb": "SPRY domain-containing SOCS box protein 3; SSB-3", "protein_names_refseq": "SPRY domain-containing SOCS box protein 3 isoform a; SPRY domain-containing SOCS box protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:79043); (R-MMU-8951664)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CGAS and SNAI1. The ECS(SPSB3) complex catalyzes 'Lys-48'-linked ubiquitination of nuclear CGAS in cycling cells, leading to its degradation. Recognizes and binds nucleosome-bound CGAS: ubiquitination and degradation of nuclear CGAS during G1 and G2 phases is required to promote low intranuclear CGAS abundance before the next mitotic cycle. The ECS(SPSB3) complex also mediates ubiquitination and degradation of phosphorylated SNAI1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0T8;Q6GQX9;Q8C6A9;Q8R4S9;Q9D7E0", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0019005 SCF ubiquitin ligase complex;GO:0031466 Cul5-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0001837 epithelial to mesenchymal transition;GO:0070936 protein K48-linked ubiquitination;GO:0010719 negative regulation of epithelial to mesenchymal transition;GO:0160049 negative regulation of cGAS/STING signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q571F5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91Z69-1", "uniprot_id": "SRGP1_MOUSE", "mass": 121430.0, "length": 1062, "protein_name": "SLIT-ROBO Rho GTPase-activating protein 1", "gene_name": "Srgap1", "organism": "Mouse", "refseq_name": "SLIT-ROBO Rho GTPase-activating protein 1 isoform 2", "refseq_ac": "NP_001229340", "gene_names_uniprotkb": "Srgap1; Arhgap13", "gene_names_refseq": "4930572H05Rik; Arhgap13; Srgap1", "protein_names_uniprotkb": "SLIT-ROBO Rho GTPase-activating protein 1; Rho GTPase-activating protein 13; srGAP1", "protein_names_refseq": "Rho GTPase activating protein 13; SLIT-ROBO Rho GTPase-activating protein 1 isoform 2; rho GTPase-activating protein 13", "tax_id": 10090, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (mmu:117600); (R-MMU-8980692); (R-MMU-9013148); (R-MMU-9013149)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11672528;16857672;19137586;21750661;22271578;22517741;22645316;26026792;29237092;32782141;33300544;33514561;40885482", "class_list": "", "function": "Data show that srGAP3 is expressed in ventricular zones of neurogenesis in many different tissues of the central nervous system., [RefSeq, PubMed]; GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract, [RefSeq, PubMed]; SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance., [RefSeq, PubMed]; SrGAP1 and srGAP3 are largely expressed in subpopulations of dorsal root ganglion neurons following sciatic nerve lesion., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q08E84", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "", "go_biological_process": "GO:0007399 nervous system development;GO:0016477 cell migration;GO:0030336 negative regulation of cell migration;GO:0007266 Rho protein signal transduction;GO:0051963 regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q91Z69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPR7-1", "uniprot_id": "SIKE1_MOUSE", "mass": 23522.0, "length": 207, "protein_name": "Suppressor of IKBKE 1", "gene_name": "Sike1", "organism": "Mouse", "refseq_name": "suppressor of IKBKE 1", "refseq_ac": "NP_079955", "gene_names_uniprotkb": "Sike1", "gene_names_refseq": "2810005O12Rik; 5730470L24Rik; Sike1; Sikeb; Sike", "protein_names_uniprotkb": "Suppressor of IKBKE 1; Suppressor of IKK-epsilon", "protein_names_refseq": "suppressor of IKBKE 1; suppressor of IKK epsilon", "tax_id": 10090, "disease": "", "pathway": " (mmu:66641)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;27249321;38354227", "class_list": "", "function": "Multispecies transcriptomics identifies SIKE as a MAPK repressor that prevents NASH progression., [RefSeq, PubMed]; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex. The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sike-deficient mice develop cardiac hypertrophy and heart failure, whereas Sike-overexpressing transgenic (Sike-TG) mice are protected from hypertrophic stimuli. Erratum:[Nat Commun. 2023 May 25;14(1):3018. doi: 10.1038/s41467-023-38331-w. PMID: 37230962] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CBP5", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0090443 FAR/SIN/STRIPAK complex", "go_biological_process": "GO:0035331 negative regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CPR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG73-1", "uniprot_id": "SH3L2_MOUSE", "mass": 12255.0, "length": 107, "protein_name": "SH3 domain-binding glutamic acid-rich-like protein 2", "gene_name": "Sh3bgrl2", "organism": "Mouse", "refseq_name": "SH3 domain-binding glutamic acid-rich-like protein 2", "refseq_ac": "NP_766095", "gene_names_uniprotkb": "Sh3bgrl2", "gene_names_refseq": "A930014C21Rik; B930089I21; Sh3bgrl2", "protein_names_uniprotkb": "SH3 domain-binding glutamic acid-rich-like protein 2", "protein_names_refseq": "SH3 domain-binding glutamic acid-rich-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:212531)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV64", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BG73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VE97-1", "uniprot_id": "SRSF4_MOUSE", "mass": 55979.0, "length": 489, "protein_name": "Serine/arginine-rich splicing factor 4", "gene_name": "Srsf4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Srsf4; MNCb-2616; Sfrs4", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 4; Splicing factor, arginine/serine-rich 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "Down syndrome (Disease Ontology:DOID:14250); colon adenocarcinoma (Disease Ontology:DOID:234); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;39627609;40997131", "class_list": "", "function": "Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJC3", "ec_number_list": "", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VE97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2M2N2-1", "uniprot_id": "SPOPL_MOUSE", "mass": 44699.0, "length": 392, "protein_name": "Speckle-type POZ protein-like", "gene_name": "Spopl", "organism": "Mouse", "refseq_name": "speckle-type POZ protein-like isoform b", "refseq_ac": "NP_001159469", "gene_names_uniprotkb": "Spopl", "gene_names_refseq": "4921517N04Rik; E430033K04Rik; Spopl", "protein_names_uniprotkb": "Speckle-type POZ protein-like; HIB homolog 2", "protein_names_refseq": "HIB homolog 2; speckle-type POZ protein-like isoform b; speckle-type POZ protein-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:76857); (R-MMU-5632684)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;16740475;19892989;21750661;25605945;34428180", "class_list": "", "function": "Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AL52;Q3TSH4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis;GO:0016567 protein ubiquitination;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q2M2N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJL3-1", "uniprot_id": "SO1B2_MOUSE", "mass": 76729.0, "length": 689, "protein_name": "Solute carrier organic anion transporter family member 1B2", "gene_name": "Slco1b2", "organism": "Mouse", "refseq_name": "solute carrier organic anion transporter family member 1B2", "refseq_ac": "NP_065241", "gene_names_uniprotkb": "Slco1b2; Oatp1b2; Slc21a10", "gene_names_refseq": "7330442B20Rik; OATP-C; OATP2; Oatp1b2; Oatp4; Slc21a10; Slc21a6; Slco1b2; lst-1; mlst-1", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 1B2; LST-1; Liver-specific organic anion transporter 1; SLC21A6; Solute carrier family 21 member 10", "protein_names_refseq": "liver-specific organic anion transporter 1; solute carrier family 21 (organic anion transporter), member 10; solute carrier family 21 (organic anion transporter), member 6; solute carrier organic anion transporter family member 1B2", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); lung cancer (Disease Ontology:DOID:1324); cholestasis (Disease Ontology:DOID:13580); colon carcinoma (Disease Ontology:DOID:1520); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); bilirubin metabolic disorder (Disease Ontology:DOID:2741); testicular cancer (Disease Ontology:DOID:2998); breast ductal carcinoma (Disease Ontology:DOID:3007); liver cancer (Disease Ontology:DOID:3571); hepatocellular carcinoma (Disease Ontology:DOID:684); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (mmu:28253); (R-MMU-159418); (R-MMU-189483); (R-MMU-879518); (R-MMU-9754706)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10833452;17208939;17242355;18492796;18630941;21183079;21750661;25428506;28389619;30084848;30955241;31967785;34428180", "class_list": "", "function": "Experiments testing the cellular uptake of androgens suggest that testosterone is an excellent substrate of OATP1B3 and cells expressing a doxycycline-inducible SLCO1B3 construct had greater uptake of a clinically relevant concentration of 3H-testosterone . When compared with Slco1b2 (-/-) mice, Slco1b2 (-/-)/hSLCO1B3 knockins had greater greater hepatic uptakeand lower plasma exposure to 3H-testosterone, [RefSeq, PubMed]; Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model., [RefSeq, PubMed]; Mediates the Na(+)-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates (estrone 3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate). Also transports prostaglandin E2 and L-thyroxine (T4). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions., [UniProtKB, UniProtKB]; Review summarizes the evidence for the important role of mouse liver-specific organic anion transporting polypeptide Oatpb2 in drug deposition and hepatotoxicity. Review article, [RefSeq, PubMed]; This finding is consistent with the metabolism of regorafenib occurring via two competing pathways, and the lack of Oatp1b2 results in decreased clearance of Regorafenib., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI79;Q9JJJ1", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity;GO:0015132 prostaglandin transmembrane transporter activity;GO:0035673 oligopeptide transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0001889 liver development;GO:0006811 monoatomic ion transport;GO:0019228 neuronal action potential;GO:0032496 response to lipopolysaccharide;GO:0050905 neuromuscular process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JJL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DA08-1", "uniprot_id": "SGF29_MOUSE", "mass": 33298.0, "length": 293, "protein_name": "SAGA-associated factor 29", "gene_name": "Sgf29", "organism": "Mouse", "refseq_name": "SAGA-associated factor 29", "refseq_ac": "NP_083615", "gene_names_uniprotkb": "Sgf29; Ccdc101", "gene_names_refseq": "1700023O11Rik; 9530025I05Rik; Ccdc101; Sgf29", "protein_names_uniprotkb": "SAGA-associated factor 29; Coiled-coil domain-containing protein 101; SAGA complex-associated factor 29", "protein_names_refseq": "SAGA-associated factor 29 homolog; SAGA-associated factor 29; coiled-coil domain containing 101; coiled-coil domain-containing protein 101", "tax_id": 10090, "disease": "diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (mmu:75565); (R-MMU-9772755)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18299400;21750661;21952136;31219806;34428180;35210392", "class_list": "", "function": "Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (By similarity). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (By similarity). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (By similarity). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (By similarity). Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-491' (PubMed:35210392)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0I6", "ec_number_list": "", "go_molecular_function": "GO:0140034 methylation-dependent protein binding;GO:0140002 histone H3K4me3 reader activity;GO:0140003 histone H3K36me3 reader activity", "go_cellular_component": "GO:0070461 SAGA-type complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000124 SAGA complex;GO:0072686 mitotic spindle", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DA08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NVE3-1", "uniprot_id": "SPI2C_MOUSE", "mass": 29207.0, "length": 257, "protein_name": "Spindlin-2C", "gene_name": "Spin2c", "organism": "Mouse", "refseq_name": "spindlin-2C", "refseq_ac": "NP_001005370", "gene_names_uniprotkb": "Spin2c; Spin2", "gene_names_refseq": "SPIN-2C; Spin2c; Spin2", "protein_names_uniprotkb": "Spindlin-2C; SPIN-2C; SPIN-2; Spindlin-like protein 2C", "protein_names_refseq": "SPIN-2; spindlin family, member 2; spindlin-2C; spindlin-2; spindlin-like protein 2C; spindlin-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:278240)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "May be involved in the regulation of cell cycle progression. Exhibits H3K4me3-binding activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6NVE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925N1-1", "uniprot_id": "SFXN4_MOUSE", "mass": 35580.0, "length": 313, "protein_name": "Sideroflexin-4", "gene_name": "Sfxn4", "organism": "Mouse", "refseq_name": "sideroflexin-4 isoform 1", "refseq_ac": "NP_444428", "gene_names_uniprotkb": "Sfxn4", "gene_names_refseq": "Sfxn4", "protein_names_uniprotkb": "Sideroflexin-4", "protein_names_refseq": "sideroflexin-4 isoform 1", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 18 (Disease Ontology:DOID:0111484)", "pathway": " (mmu:94281)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11274051;21750661;35820727", "class_list": "", "function": "Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKN7;Q5FW99", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015075 monoatomic ion transmembrane transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:1990542 mitochondrial transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q925N1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VDS8-1", "uniprot_id": "STX18_MOUSE", "mass": 38381.0, "length": 334, "protein_name": "Syntaxin-18", "gene_name": "Stx18", "organism": "Mouse", "refseq_name": "syntaxin-18 isoform 2", "refseq_ac": "NP_001276464", "gene_names_uniprotkb": "Stx18", "gene_names_refseq": "1810035L21Rik; 4933425D03Rik; Stx18", "protein_names_uniprotkb": "Syntaxin-18", "protein_names_refseq": "syntaxin-18 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71116); (R-MMU-6811434)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16790498;19710423;21750661;30779550;34428180;35820727", "class_list": "", "function": "Domain analyses of Sec22b revealed that the R-SNARE motif, a selective domain for forming a SNARE complex with syntaxin18 and/or D12, was responsible for the inhibition of phagocytosis., [RefSeq, PubMed]; Syntaxin 18 is involved in endoplasmic reticulum (ER)-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER and plasma or phagosomal membranes., [RefSeq, PubMed]; Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDJ0;Q9D8T6", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031201 SNARE complex", "go_biological_process": "GO:1902117 positive regulation of organelle assembly;GO:0090158 endoplasmic reticulum membrane organization;GO:0006886 intracellular protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VDS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0F3-1", "uniprot_id": "SUMF1_MOUSE", "mass": 40659.0, "length": 372, "protein_name": "Formylglycine-generating enzyme", "gene_name": "Sumf1", "organism": "Mouse", "refseq_name": "formylglycine-generating enzyme isoform 1 precursor", "refseq_ac": "NP_666049", "gene_names_uniprotkb": "Sumf1; Fge", "gene_names_refseq": "FGE; Sumf1", "protein_names_uniprotkb": "Formylglycine-generating enzyme; 1.8.3.7; C-alpha-formylglycine-generating enzyme 1; FGE; Sulfatase-modifying factor 1", "protein_names_refseq": "C-alpha-formylglycine-generating enzyme 1; formylglycine-generating enzyme isoform 1 precursor", "tax_id": 10090, "disease": "mucosulfatidosis (Disease Ontology:DOID:0050441)", "pathway": " (mmu:58911); (R-MMU-1663150); (R-MMU-9840310)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;17360554;21750661;30899004;36433920", "class_list": "glycogene", "function": "New mouse models with hypomorphic SUMF1 variants mimic attenuated forms of multiple sulfatase deficiency., [RefSeq, PubMed]; Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 33, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTT6;Q3TXM8;Q3U9A5", "ec_number_list": "3.1.6.2;3.1.6.8;3.1.6.12;3.1.6.-;3.1.6.1;3.1.6.15;1.8.3.7;3.1.6.18", "go_molecular_function": "GO:0042802 identical protein binding;GO:1903135 cupric ion binding;GO:0120147 formylglycine-generating oxidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0018158 protein oxidation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R0F3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35400-1", "uniprot_id": "ST2B1_MOUSE", "mass": 38347.0, "length": 338, "protein_name": "Sulfotransferase 2B1", "gene_name": "Sult2b1", "organism": "Mouse", "refseq_name": "sulfotransferase 2B1 isoform 1", "refseq_ac": "NP_059493", "gene_names_uniprotkb": "Sult2b1; Sult2b", "gene_names_refseq": "ST2B1; SULT2B; Sult2b1", "protein_names_uniprotkb": "Sulfotransferase 2B1; 2.8.2.2; Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2; ST2B1; Sulfotransferase family cytosolic 2B member 1", "protein_names_refseq": "alcohol sulfotransferase; hydroxysteroid sulfotransferase 2; sulfotransferase 2B1 isoform 1; sulfotransferase 2B1; sulfotransferase 2B", "tax_id": 10090, "disease": "autosomal recessive congenital ichthyosis 14 (Disease Ontology:DOID:0080258)", "pathway": " (mmu:54200); (R-MMU-156584)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11988083;12639899;20718863;21750661;38286358;9647753", "class_list": "", "function": "During embryonic development, SULT2B1b is required for production of cholesterol sulfate essential for normal skin development, [RefSeq, PubMed]; Elevation of hepatic sulphotransferase activities in mice with resistance to cystic fibrosis, [RefSeq, PubMed]; Reducing SULT2B1 promotes the interaction of LncRNAgga3-204 with SMAD4 to inhibit the macrophage inflammatory response and delay atherosclerosis progression., [RefSeq, PubMed]; Results suggested that the unique, extended proline/serine-rich C-terminus of SULT2B1b is important for its interaction with cytoskeletal proteins, [RefSeq, PubMed]; Strongly sulfonates pregnenolone, however is capable to sulfonate cholesterol with a high degree of efficiency. DHEA is a relatively poor substrate., [UniProtKB, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Preferentially sulfonates cholesterol (PubMed:12639899). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Cholesterol sulfation is approximately 10-fold higher than for pregnenolone and 20-fold higher than for DHEA (PubMed:12639899). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K472;Q91V03", "ec_number_list": "2.8.2.-;2.8.2.14;2.8.2.2;2.8.2.4;2.8.2.1", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0050294 steroid sulfotransferase activity;GO:0015485 cholesterol binding;GO:0003676 nucleic acid binding;GO:0036094 small molecule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0008203 cholesterol metabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0045606 positive regulation of epidermal cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35400-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6JHY2-1", "uniprot_id": "SMGC_MOUSE", "mass": 74383.0, "length": 733, "protein_name": "Submandibular gland protein C", "gene_name": "Muc19; Smgc", "organism": "Mouse", "refseq_name": "submandibular gland protein C precursor", "refseq_ac": "NP_945121", "gene_names_uniprotkb": "Muc19; Smgc; Smgc", "gene_names_refseq": "2310010P21Rik; DXImx49e; Muc19/Smgc; Muc19; Sfc21; Smgc", "protein_names_uniprotkb": "Submandibular gland protein C", "protein_names_refseq": "mucin 19; neonatal submandibular gland protein C; submandibular gland protein C precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:223809)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15256252;15340121;21750661;35820727", "class_list": "", "function": "", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A7UN65;Q3V1B0;Q58E46;Q6IS33;Q7TNU8;Q80ZH6", "ec_number_list": "", "go_molecular_function": "GO:0046848 hydroxyapatite binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0045087 innate immune response;GO:0070098 chemokine-mediated signaling pathway;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6JHY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2C9-1", "uniprot_id": "SNPC3_MOUSE", "mass": 46277.0, "length": 407, "protein_name": "snRNA-activating protein complex subunit 3", "gene_name": "Snapc3", "organism": "Mouse", "refseq_name": "snRNA-activating protein complex subunit 3 isoform 1", "refseq_ac": "NP_084225", "gene_names_uniprotkb": "Snapc3", "gene_names_refseq": "1810020H02Rik; 4930558A07Rik; 5031401C21Rik; E030018J20Rik; Snapc3", "protein_names_uniprotkb": "snRNA-activating protein complex subunit 3; SNAPc subunit 3; Small nuclear RNA-activating complex polypeptide 3", "protein_names_refseq": "SNAPc subunit 3; snRNA-activating protein complex subunit 3 isoform 1; snRNA-activating protein complex subunit 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:77634); (R-MMU-6807505); (R-MMU-76071)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21183079;21750661;30084848;34428180", "class_list": "", "function": "Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0A5", "ec_number_list": "", "go_molecular_function": "GO:0003681 bent DNA binding;GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016604 nuclear body;GO:0019185 snRNA-activating protein complex", "go_biological_process": "GO:0042795 snRNA transcription by RNA polymerase II;GO:0042796 snRNA transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D2C9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D176-1", "uniprot_id": "SUSD3_MOUSE", "mass": 28285.0, "length": 269, "protein_name": "Sushi domain-containing protein 3", "gene_name": "Susd3", "organism": "Mouse", "refseq_name": "sushi domain-containing protein 3 isoform 1", "refseq_ac": "NP_079767", "gene_names_uniprotkb": "Susd3", "gene_names_refseq": "1700017I11Rik; 2810440J20Rik; Susd3", "protein_names_uniprotkb": "Sushi domain-containing protein 3", "protein_names_refseq": "sushi domain-containing protein 3 isoform 1; sushi domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66329)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80XL5;Q9CYV1;Q9DA86", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D176-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52840-1", "uniprot_id": "ST1A1_MOUSE", "mass": 33974.0, "length": 291, "protein_name": "Sulfotransferase 1A1", "gene_name": "Sult1a1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sult1a1; St1a1; Stp1; Stp", "gene_names_refseq": "", "protein_names_uniprotkb": "Sulfotransferase 1A1; 2.8.2.1; Aryl sulfotransferase; Phenol sulfotransferase; Phenol/aryl sulfotransferase; ST1A1; ST1A4; Sulfokinase; mSTp1", "protein_names_refseq": "", "tax_id": 10090, "disease": "benign neoplasm (Disease Ontology:DOID:0060072); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (R-MMU-156584); (R-MMU-9753281)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;34428180;35165440;37453647;8424956", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. Catalyzes the sulfate conjugation of dopamine. Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-;2.8.2.n2;2.8.2.4;2.8.2.2;2.8.2.1", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0047894 flavonol 3-sulfotransferase activity;GO:0050294 steroid sulfotransferase activity;GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0051923 sulfation;GO:0051384 response to glucocorticoid;GO:0006805 xenobiotic metabolic process;GO:0042420 dopamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P52840-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7A6-1", "uniprot_id": "SRP19_MOUSE", "mass": 16191.0, "length": 144, "protein_name": "Signal recognition particle 19 kDa protein", "gene_name": "Srp19", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Srp19", "gene_names_refseq": "", "protein_names_uniprotkb": "Signal recognition particle 19 kDa protein; SRP19", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-1799339)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;36210013", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of SRP54 to the SRP complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0048500 signal recognition particle", "go_biological_process": "GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition;GO:0006614 SRP-dependent cotranslational protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7A6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q497V5-1", "uniprot_id": "SRBD1_MOUSE", "mass": 110281.0, "length": 982, "protein_name": "S1 RNA-binding domain-containing protein 1", "gene_name": "Srbd1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Srbd1", "gene_names_refseq": "", "protein_names_uniprotkb": "S1 RNA-binding domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:78586)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;25428506;28135057;30084848;31219806;34428180", "class_list": "", "function": "DNA- and histone-binding protein that localizes to the central axes of mitotic chromosomes. Promotes chromosome segregation by facilitating TOP2A recruitment to mitotic chromosomes, thereby preventing anaphase failure. During prophase, safeguards the decatenation process to avoid the formation of difficult-to-resolve DNA structures, preventing chromosome missegregation. Also contributes to the regulation of nucleus pulposus cell senescence., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome;GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006412 translation;GO:0006139 nucleobase-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q497V5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZI8-1", "uniprot_id": "SERC1_MOUSE", "mass": 50509.0, "length": 453, "protein_name": "Serine incorporator 1", "gene_name": "Serinc1", "organism": "Mouse", "refseq_name": "serine incorporator 1", "refseq_ac": "NP_062734", "gene_names_uniprotkb": "Serinc1; Aigp2; Tde1l; Tde2; Tms2", "gene_names_refseq": "1500011D18Rik; AIGP-2; Serinc1; TMS-2; Tde1l; Tde2; Tms2; mKIAA1253", "protein_names_uniprotkb": "Serine incorporator 1; Axotomy-induced glyco/Golgi protein 2; Membrane protein TMS-2; Tumor differentially expressed protein 1-like; Tumor differentially expressed protein 2", "protein_names_refseq": "axotomy induced glycoprotein 2; axotomy-induced glyco/Golgi protein 2; membrane protein TMS-2; serine incorporator 1; tumor differentially expressed 1, like; tumor differentially expressed 2; tumor differentially expressed protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56442); (R-MMU-977347)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10637174;19144319;21750661;27802388;28006656", "class_list": "", "function": "Enhances the incorporation of serine into phosphatidylserine and sphingolipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results suggest that Serinc1 is dispensable for certain immune cell functions and does not contribute to previously reported links between lipid composition in immune cells and autoimmunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZ93", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0030674 protein-macromolecule adaptor activity;GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0008654 phospholipid biosynthetic process;GO:0044091 membrane biogenesis;GO:0006658 phosphatidylserine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QZI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0G7-1", "uniprot_id": "SPNS1_MOUSE", "mass": 56709.0, "length": 528, "protein_name": "Protein spinster homolog 1", "gene_name": "Spns1", "organism": "Mouse", "refseq_name": "protein spinster homolog 1", "refseq_ac": "NP_076201", "gene_names_uniprotkb": "Spns1", "gene_names_refseq": "2210013K02Rik; Spin1; Spinl; Spns1", "protein_names_uniprotkb": "Protein spinster homolog 1; MSpin1; Spns1", "protein_names_refseq": "MSpin1; protein spinster homolog 1; spinster homolog 1; spinster-like protein", "tax_id": 10090, "disease": "neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); sphingolipidosis (Disease Ontology:DOID:1927)", "pathway": " (mmu:73658)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11340170;21750661;29162837;34428180;36161949;38451736;40885482", "class_list": "", "function": "Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol (PubMed:36161949). Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids (PubMed:36161949). Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), can also transport lysophosphatidylglycerol (LPG), but not other anionic lysophospholipids, sphingosine, nor sphingomyelin (PubMed:36161949). Transports lysophospholipids with saturated, monounsaturated, and polyunsaturated fatty acids, such as 1-hexadecanoyl-sn-glycero-3-phosphocholine, 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine, respectively (PubMed:36161949). Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine. Essential player in lysosomal homeostasis (PubMed:36161949). Crucial for cell survival under conditions of nutrient limitation. May be involved in necrotic or autophagic cell death (By similarity)., [UniProtKB, UniProtKB, PubMed]; SPNS1-dependent L-leucine export across the lysosomal membrane is a key step for triggering autophagy, and that this mechanism is impaired in Niemann-Pick type C disease-1. Publication Status: Online-Only, [RefSeq, PubMed]; Spinster protein interferes with programmed cell death in Drosophila melanogaster and has orthologs in nematode, mouse, and human., [RefSeq, PubMed]; Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKM0;Q99LN7;Q9EQK0", "ec_number_list": "", "go_molecular_function": "GO:0051978 lysophospholipid:sodium symporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0051977 lysophospholipid transport;GO:0033700 phospholipid efflux;GO:0035751 regulation of lysosomal lumen pH;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R0G7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WU12-1", "uniprot_id": "SNURF_MOUSE", "mass": 8407.0, "length": 71, "protein_name": "SNRPN upstream reading frame protein", "gene_name": "Gm38393; Snurf", "organism": "Mouse", "refseq_name": "SNURF protein", "refseq_ac": "NP_149409", "gene_names_uniprotkb": "Gm38393; Snurf", "gene_names_refseq": "2410045I01Rik; Snurf", "protein_names_uniprotkb": "SNRPN upstream reading frame protein", "protein_names_refseq": "SNURF protein; small nuclear ribonucleoprotein N", "tax_id": 10090, "disease": "", "pathway": " (mmu:84704)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10318933;11431693;12075010;16429232;21750661", "class_list": "", "function": "The ATG-to-AAG mutation causes a 15-fold or more increase in translation of the downstream ORF in two fusion constructs, and it is likely that similar translational control affects the normal Snurf-Snrpn transcript as well, [RefSeq, PubMed]; This gene is located within the mouse orthologous Prader-Willi Syndrome critical region and is imprinted and expressed from the paternal allele. This transcipt is thought to be bicistronic and can encode the small nuclear ribonucleoprotein polypeptide N (Snrpn) from a downstream open reading frame. The small protein represented by this gene is encoded by an evolutionarily-conserved upstream open reading frame and is localized to the nucleus. [provided by RefSeq, Mar 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q924D8", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WU12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VD57-1", "uniprot_id": "SFT2B_MOUSE", "mass": 17499.0, "length": 159, "protein_name": "Vesicle transport protein SFT2B", "gene_name": "Sft2d2", "organism": "Mouse", "refseq_name": "vesicle transport protein SFT2B", "refseq_ac": "NP_663487", "gene_names_uniprotkb": "Sft2d2", "gene_names_refseq": "2010005O13Rik; Sft2d2; cI-45", "protein_names_uniprotkb": "Vesicle transport protein SFT2B; SFT2 domain-containing protein 2", "protein_names_refseq": "SFT2 domain-containing protein 2; vesicle transport protein SFT2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:108735)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19144319;21750661;34428180", "class_list": "", "function": "May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VD57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DCT5-1", "uniprot_id": "SDF2_MOUSE", "mass": 23159.0, "length": 211, "protein_name": "Stromal cell-derived factor 2", "gene_name": "Sdf2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sdf2", "gene_names_refseq": "", "protein_names_uniprotkb": "Stromal cell-derived factor 2; SDF-2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:20316)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;34428180;8918255", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97307", "ec_number_list": "", "go_molecular_function": "GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DCT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2Y5-1", "uniprot_id": "SNX20_MOUSE", "mass": 36028.0, "length": 313, "protein_name": "Sorting nexin-20", "gene_name": "Snx20", "organism": "Mouse", "refseq_name": "sorting nexin-20", "refseq_ac": "NP_082116", "gene_names_uniprotkb": "Snx20", "gene_names_refseq": "9130017C17Rik; Snx20", "protein_names_uniprotkb": "Sorting nexin-20", "protein_names_refseq": "sorting nexin-20", "tax_id": 10090, "disease": "", "pathway": " (mmu:71607)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18196517;21750661;25882846;30084848", "class_list": "", "function": "May play a role in cellular vesicle trafficking (PubMed:25882846). Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, nor on SELPLG-mediated cell-cell adhesion (PubMed:18196517)., [UniProtKB, PubMed, PubMed]; SAXS solution structures of SNX20 and SNX21 show that the proteins adopt a compact globular architecture; membrane interaction analyses indicate the presence of phosphoinositide -binding sites that may regulate their intracellular localization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0B6;Q544B6;Q8CHQ3", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D2Y5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WD9-1", "uniprot_id": "SEGN_MOUSE", "mass": 32146.0, "length": 276, "protein_name": "Secretagogin", "gene_name": "Scgn", "organism": "Mouse", "refseq_name": "secretagogin", "refseq_ac": "NP_663374", "gene_names_uniprotkb": "Scgn", "gene_names_refseq": "Scgn", "protein_names_uniprotkb": "Secretagogin", "protein_names_refseq": "secretagogin", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:214189)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;20018755;21750661;35870554;36036556", "class_list": "", "function": "Scgn is a marker of neuroblasts commuting in the rostral migratory stream. Terminally differentiated neurons in the olfactory bulb retain scgn expression, with scgn being present in periglomerular cells and granular layer interneurons., [RefSeq, PubMed]; Secretagogin is a Ca(2+)-dependent stress-responsive chaperone that may also play a role in aggregation-based proteinopathies., [RefSeq, PubMed]; The Cytoskeletal Transport Protein, Secretagogin, Is Essential for Diurnal Glucagon-like Peptide-1 Secretion in Mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043195 terminal bouton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91WD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VIK1-1", "uniprot_id": "SNR25_MOUSE", "mass": 14292.0, "length": 123, "protein_name": "U11/U12 small nuclear ribonucleoprotein 25 kDa protein", "gene_name": "Snrnp25", "organism": "Mouse", "refseq_name": "U11/U12 small nuclear ribonucleoprotein 25 kDa protein", "refseq_ac": "NP_084369", "gene_names_uniprotkb": "Snrnp25", "gene_names_refseq": "3300001G02Rik; C16ORF33; Snrnp25", "protein_names_uniprotkb": "U11/U12 small nuclear ribonucleoprotein 25 kDa protein; U11/U12 snRNP 25 kDa protein", "protein_names_refseq": "U11/U12 small nuclear ribonucleoprotein 25 kDa protein; U11/U12 snRNP 25 kDa protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:78372); (R-MMU-72165)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11157800;21750661;25428506;30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CX75", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0045171 intercellular bridge", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VIK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTP3-1", "uniprot_id": "SPDEF_MOUSE", "mass": 36356.0, "length": 325, "protein_name": "SAM pointed domain-containing Ets transcription factor", "gene_name": "Spdef", "organism": "Mouse", "refseq_name": "SAM pointed domain-containing Ets transcription factor", "refseq_ac": "NP_038919", "gene_names_uniprotkb": "Spdef; Pdef; Pse", "gene_names_refseq": "PDEF; Pse; Spdef", "protein_names_uniprotkb": "SAM pointed domain-containing Ets transcription factor; Prostate epithelium-specific Ets transcription factor; Prostate-derived Ets factor; Prostate-specific Ets", "protein_names_refseq": "SAM pointed domain-containing Ets transcription factor; prostate epithelium-specific Ets transcription factor; prostate specific ets transcription factor; prostate-derived Ets factor; prostate-specific Ets", "tax_id": 10090, "disease": "ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (mmu:30051)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10675039;17347682;21750661;37515878", "class_list": "", "function": "Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway., [RefSeq, PubMed]; May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; SPDEF was induced following intratracheal allergen exposure and after Th2 cytokine stimulation and was sufficient to cause goblet cell differentiation of Clara cells in vivo., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0010454 negative regulation of cell fate commitment;GO:0010455 positive regulation of cell fate commitment;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WTP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VZ6-1", "uniprot_id": "SMAP1_MOUSE", "mass": 47660.0, "length": 440, "protein_name": "Stromal membrane-associated protein 1", "gene_name": "Smap1", "organism": "Mouse", "refseq_name": "stromal membrane-associated protein 1 isoform 2", "refseq_ac": "NP_001277612", "gene_names_uniprotkb": "Smap1", "gene_names_refseq": "1700056O10Rik; 4921514B13Rik; 4921525H11Rik; Smap1", "protein_names_uniprotkb": "Stromal membrane-associated protein 1", "protein_names_refseq": "stromal membrane-associated protein 1 isoform 2; stromal membrane-associated protein 1", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:98366)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15659652;21750661;23434593;26296315;30084848;31219806;40885482;40997131;9644265", "class_list": "", "function": "Either SMAP1 or SMAP2, is required for proper embryogenesis, [RefSeq, PubMed]; Enhanced endocytosis of transferrin in Smap1-targeted mice might facilitate the active iron metabolism and c-KIT-induced growth of erythroblasts and myelodysplastic syndrome/acute myeloid leukemia cells., [RefSeq, PubMed]; GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q497I6;Q68EF3", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0030276 clathrin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:2000369 regulation of clathrin-dependent endocytosis;GO:0045648 positive regulation of erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91VZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EP96-1", "uniprot_id": "SO1A4_MOUSE", "mass": 73965.0, "length": 670, "protein_name": "Solute carrier organic anion transporter family member 1A4", "gene_name": "Slco1a4", "organism": "Mouse", "refseq_name": "solute carrier organic anion transporter family member 1A4", "refseq_ac": "NP_109612", "gene_names_uniprotkb": "Slco1a4; Oatp1a4; Oatp2; Slc21a5", "gene_names_refseq": "Oatp1a4; Oatp2; Slc21a5; Slco1a4", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 1A4; Sodium-independent organic anion-transporting polypeptide 2; Solute carrier family 21 member 5", "protein_names_refseq": "organic anion transporting polypeptide 2; sodium-independent organic anion-transporting polypeptide 2; solute carrier family 21 (organic anion transporter), member 5; solute carrier family 21 member 5; solute carrier organic anion transporter family member 1A4", "tax_id": 10090, "disease": "Dubin-Johnson syndrome (Disease Ontology:DOID:12308); cholestasis (Disease Ontology:DOID:13580); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:28250); (R-MMU-159418); (R-MMU-879518); (R-MMU-9793528)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11181066;18703564;21750661;23747753;29348124;31219806;34428180", "class_list": "", "function": "Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, prostaglandin E2, estrone 3-sulfate, L-thyroxine (T4), the cardiac glycosides ouabain and digoxin and thyroid hormones. Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions., [UniProtKB, UniProtKB]; Oatp1a4 does not appear to mediate the hepatic uptake of bile acid, but plays an important male-predominant role in secondary bile acid metabolism., [RefSeq, PubMed]; Oatp1a4 plays a major role in the hepatic accumulation of cardiac glycosides in mice., [RefSeq, PubMed]; Report critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp1a4 uptake transporter in mouse liver., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0015721 bile acid and bile salt transport;GO:0071466 cellular response to xenobiotic stimulus;GO:0043627 response to estrogen;GO:0043252 sodium-independent organic anion transport;GO:0006820 monoatomic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EP96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXZ6-1", "uniprot_id": "SO1A1_MOUSE", "mass": 74396.0, "length": 670, "protein_name": "Solute carrier organic anion transporter family member 1A1", "gene_name": "Slco1a1", "organism": "Mouse", "refseq_name": "solute carrier organic anion transporter family member 1A1", "refseq_ac": "NP_038825", "gene_names_uniprotkb": "Slco1a1; Oatp1a1; Slc21a1", "gene_names_refseq": "A530084B21; OATP-1; Oatp1a1; Oatp1; Slc21a1; Slco1a1", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 1A1; OATP-1; Sodium-independent organic anion-transporting polypeptide 1; Solute carrier family 21 member 1", "protein_names_refseq": "sodium-independent organic anion-transporting polypeptide 1; solute carrier family 21 (organic anion transporter), member 1; solute carrier family 21 member 1; solute carrier organic anion transporter family member 1A1", "tax_id": 10090, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); Dubin-Johnson syndrome (Disease Ontology:DOID:12308)", "pathway": " (mmu:28248)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10600646;11267661;12399219;21750661;27449599;27777271;34428180;39009243", "class_list": "", "function": "Important roles for OATP1A/1B in transporter-mediated uptake and disposition of doxorubicin, are reported., [RefSeq, PubMed]; Inhibition of hepatic bile salt uptake by Bulevirtide reduces atherosclerosis in Oatp1a1[-/-]Ldlr[-/-] mice., [RefSeq, PubMed]; Mediates the Na(+)-independent transport of organic anions such as steroid sulfate conjugates (dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate), conjugated (taurocholate) and unconjugated (cholate) bile acids, prostaglandin E2 (PGE2) and L-thyroxine T4 (PubMed:10600646, PubMed:11267661). Also capable of transporting sulfobromophthalein (BSP), ouabain and gadoxetate (PubMed:10600646). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Organic anion transporting polypeptide-1 (Oatp1) were down-regulated by taurocholate and not affected by cholestyramine feeding, [RefSeq, PubMed]; Organic anion-transporting polypeptides exert strong impact on disposition and toxicity of antitumor drugs. (Review) Review article, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015721 bile acid and bile salt transport;GO:0006805 xenobiotic metabolic process;GO:0015711 organic anion transport;GO:0008206 bile acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QXZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WP6-1", "uniprot_id": "SPA3N_MOUSE", "mass": 46718.0, "length": 418, "protein_name": "Serine protease inhibitor A3N", "gene_name": "Serpina3n", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Serpina3n; Spi2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine protease inhibitor A3N; Serpin A3N", "protein_names_refseq": "", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); uveitis (Disease Ontology:DOID:13141); cystic fibrosis (Disease Ontology:DOID:1485); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); vasculitis (Disease Ontology:DOID:865)", "pathway": " (mmu:20716); (R-MMU-114608); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12659817;15638460;16141197;1718822;21750661;34428180;37507081", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q62258", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006953 acute-phase response;GO:0009617 response to bacterium;GO:0034097 response to cytokine;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q91WP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09133-1", "uniprot_id": "SMR2A_MOUSE", "mass": 16630.0, "length": 150, "protein_name": "Submaxillary gland androgen-regulated protein 2, isoform alpha", "gene_name": "Smr2", "organism": "Mouse", "refseq_name": "submaxillary gland androgen regulated protein 2 isoform X1", "refseq_ac": "XP_030110128", "gene_names_uniprotkb": "Smr2; Msg2; Vcs2", "gene_names_refseq": "MSG2; Smr2; Vcs2", "protein_names_uniprotkb": "Submaxillary gland androgen-regulated protein 2, isoform alpha; Salivary protein MSG2, isoform alpha", "protein_names_refseq": "submaxillary gland androgen regulated protein 2 isoform X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20600)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8194749;9409774", "class_list": "", "function": "May play a role in protection or detoxification., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030414 peptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0051930 regulation of sensory perception of pain;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O09133-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VHL1-1", "uniprot_id": "SETD7_MOUSE", "mass": 40506.0, "length": 366, "protein_name": "Histone-lysine N-methyltransferase SETD7", "gene_name": "Setd7", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase SETD7", "refseq_ac": "NP_542983", "gene_names_uniprotkb": "Setd7; Kiaa1717; Set7; Set9", "gene_names_refseq": "1600028F23Rik; H3K4MT; KMT7; Set7/9; Set7; Setd7; mKIAA1717", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETD7; 2.1.1.364; H3-K4-HMTase SETD7; Histone H3-K4 methyltransferase SETD7; SET domain-containing protein 7; SET7/9", "protein_names_refseq": "H3-K4 methyltransferase; H3-K4-HMTase SETD7; SET domain-containing protein 7; histone H3-K4 methyltransferase SETD7; histone-lysine N-methyltransferase SETD7", "tax_id": 10090, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); extrahepatic cholestasis (Disease Ontology:DOID:13619)", "pathway": " (mmu:73251); (R-MMU-3214841)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11779497;12711597;15975555;18280244;25428506;31219806;34737104;35210392;35791576;36285636", "class_list": "", "function": "Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:12711597). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (By similarity). Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:35210392). Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (By similarity). Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (By similarity). Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (PubMed:35210392). Acts as a positive regulator of smoothened signaling by mediating methylation of full-length GLI3, increasing GLI3 ability to bind DNA (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; LncRNA SNHG15 regulates hypoxic-ischemic brain injury via miR-153-3p/SETD7 axis., [RefSeq, PubMed]; Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development., [RefSeq, PubMed]; Methylation of p53 by Set7 mediates p53 acetylation and activity in vivo., [RefSeq, PubMed]; Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPJ6;Q80UU3;Q8C7Y6", "ec_number_list": "2.1.1.-;2.1.1.364;2.1.1.359;2.1.1.361;2.1.1.370;2.1.1.371;2.1.1.354;2.1.1.85;2.1.1.355;2.1.1.362", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042054 histone methyltransferase activity;GO:0002039 p53 binding;GO:0016279 protein-lysine N-methyltransferase activity;GO:0140945 histone H3K4 monomethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006974 DNA damage response;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0006479 protein methylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VHL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WV7-1", "uniprot_id": "SLC31_MOUSE", "mass": 78118.0, "length": 685, "protein_name": "Amino acid transporter heavy chain SLC3A1", "gene_name": "Slc3a1", "organism": "Mouse", "refseq_name": "amino acid transporter heavy chain SLC3A1", "refseq_ac": "NP_033231", "gene_names_uniprotkb": "Slc3a1; Nbat", "gene_names_refseq": "D2H; D2; NBAT; NTAA; RBAT; Slc3a1", "protein_names_uniprotkb": "Amino acid transporter heavy chain SLC3A1; D2; NBAT; Neutral and basic amino acid transport protein; Solute carrier family 3 member 1; b(0,+)-type amino acid transporter-related heavy chain; rBAT", "protein_names_refseq": "amino acid transporter heavy chain SLC3A1; b(0,+)-type amino acid transport protein; b(0,+)-type amino acid transporter-related heavy chain; neutral and basic amino acid transport protein rBAT", "tax_id": 10090, "disease": "cystinuria (Disease Ontology:DOID:9266)", "pathway": " (mmu:20532); (R-MMU-352230)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12167606;26739563;32078250;32873097", "class_list": "glycogene;glycosylhydrolase", "function": "A decreasing expression gradient of heterodimeric rBAT-b(0,+)AT along the proximal tubule is responsible for virtually all apical cystine reabsorption, [RefSeq, PubMed]; Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heteromers to the plasma membrane (By similarity) (PubMed:26739563). Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine. SLC7A9-SLC3A1 acts as a major transporter for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in early proximal tubules (By similarity). Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion. SLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate (PubMed:26739563)., [UniProtKB, UniProtKB, PubMed]; CRISPR/Cas9 engineering of albino cystinuria Type A mice., [RefSeq, PubMed]; Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 42, "reported_interactions": 0, "missing_score": 8496, "biomarker_type": "", "glycan_count": 14, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016324 apical plasma membrane;GO:0005774 vacuolar membrane;GO:0031526 brush border membrane;GO:1902495 transmembrane transporter complex", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006865 amino acid transport;GO:0015811 L-cystine transport;GO:0010467 gene expression;GO:0015810 aspartate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q91WV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99J94-1", "uniprot_id": "SO1A6_MOUSE", "mass": 74145.0, "length": 670, "protein_name": "Solute carrier organic anion transporter family member 1A6", "gene_name": "Slco1a6", "organism": "Mouse", "refseq_name": "solute carrier organic anion transporter family member 1A6", "refseq_ac": "NP_076207", "gene_names_uniprotkb": "Slco1a6; Oatp5; Slc21a13", "gene_names_refseq": "4930422F19Rik; Oatp-5; Oatp5; Slc21a13; Slco1a6", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 1A6; Kidney-specific organic anion-transporting polypeptide 5; OATP-5; Solute carrier family 21 member 13", "protein_names_refseq": "kidney-specific organic anion-transporting polypeptide 5; solute carrier family (organic anion transporter) member 13; solute carrier family 21 (organic anion transporter), member 13; solute carrier family 21 member 13; solute carrier organic anion transporter family member 1A6", "tax_id": 10090, "disease": "", "pathway": " (mmu:28254)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11162483;21183079;26385979;34428180", "class_list": "", "function": "May mediate the Na(+)-independent transport of organic anions., [UniProtKB]; Results suggest that genetic variation in Slco1a6 leads to altered transport of taurocholic acid and potentially other bile acids) by pancreatic islets, resulting in broad gene regulation, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQC6;Q9CUP7", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015721 bile acid and bile salt transport;GO:0035264 multicellular organism growth;GO:0006805 xenobiotic metabolic process;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99J94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CPV1-1", "uniprot_id": "SKA1_MOUSE", "mass": 29459.0, "length": 254, "protein_name": "SKA complex subunit 1", "gene_name": "Ska1", "organism": "Mouse", "refseq_name": "SKA complex subunit 1", "refseq_ac": "NP_001157827", "gene_names_uniprotkb": "Ska1", "gene_names_refseq": "2810433K01Rik; Ska1", "protein_names_uniprotkb": "SKA complex subunit 1; Spindle and kinetochore-associated protein 1", "protein_names_refseq": "SKA complex subunit 1; spindle and kinetochore-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66468); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "21750661;22336914;24827423", "class_list": "", "function": "Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint (By similarity). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules (By similarity). The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle (By similarity). The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces (By similarity). The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules (By similarity). The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase (By similarity). In the complex, it mediates interactions with microtubules (By similarity). It also stimulates AURKB/Aurora B catalytic activity (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (PubMed:22336914)., [UniProtKB, UniProtKB, PubMed]; Ska1 over-expression promotes tumourigenesis, [RefSeq, PubMed]; The Ska1 subunit was only localized on spindle microtubules from the Pro-MI to MII stages in mouse oocyte meiosis and knockdown by Morpholino injection into mouse oocytes resulted in spindle movement defects and enlarged polar bodies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J0M5;Q005W7;Q8VE34;Q9CYW9", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0045171 intercellular bridge", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051310 metaphase chromosome alignment;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CPV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQK8-1", "uniprot_id": "SP2A1_MOUSE", "mass": 9408.0, "length": 83, "protein_name": "Small proline-rich protein 2A1", "gene_name": "Sprr2a1", "organism": "Mouse", "refseq_name": "small proline-rich protein 2A1", "refseq_ac": "NP_001158259", "gene_names_uniprotkb": "Sprr2a1; Sprr2a", "gene_names_refseq": "Sprr2a1; Sprr2a2; Sprr2a3; Sprr2a", "protein_names_uniprotkb": "Small proline-rich protein 2A1; small proline-rich protein 2A", "protein_names_refseq": "Small proline-rich protein 2A3; small proline-rich protein 2A1; small proline-rich protein 2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042514); (mmu:100303744); (mmu:20755)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12584609;34735226;9888996", "class_list": "", "function": "Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (By similarity). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (PubMed:34735226). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidences are required to confirm this result in vivo (By similarity)., [UniProtKB, PubMed, UniProtKB]; Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70553", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030141 secretory granule;GO:0030133 transport vesicle", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0050830 defense response to Gram-positive bacterium;GO:0032355 response to estradiol;GO:0008360 regulation of cell shape;GO:0048874 host-mediated modulation of intestinal microbiota composition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQN4-1", "uniprot_id": "SOSD1_MOUSE", "mass": 23174.0, "length": 206, "protein_name": "Sclerostin domain-containing protein 1", "gene_name": "Sostdc1", "organism": "Mouse", "refseq_name": "sclerostin domain-containing protein 1 precursor", "refseq_ac": "NP_079588", "gene_names_uniprotkb": "Sostdc1; Sostl; Usag1", "gene_names_refseq": "0610006G05Rik; Sostdc1; Sostl; USAG-1; Wise; ectodin", "protein_names_uniprotkb": "Sclerostin domain-containing protein 1; Ectodermal BMP inhibitor; Ectodin; Sclerostin-like protein; USAG-1; Uterine sensitization-associated gene 1 protein", "protein_names_refseq": "cystine-knot containing secreted protein; ectodermal BMP inhibitor; sclerostin domain-containing protein 1 precursor; sclerostin domain-containing protein 1; sclerostin-like protein; uterine sensitization-associated gene 1 protein; uterine sensitization-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66042)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12617826;14623234;15020244", "class_list": "", "function": "Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways, [RefSeq, PubMed]; May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CF09", "ec_number_list": "", "go_molecular_function": "GO:0098821 BMP receptor activity;GO:0036122 BMP binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060648 mammary gland bud morphogenesis;GO:0010454 negative regulation of cell fate commitment;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0030514 negative regulation of BMP signaling pathway;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D361-1", "uniprot_id": "SNR48_MOUSE", "mass": 39453.0, "length": 337, "protein_name": "U11/U12 small nuclear ribonucleoprotein 48 kDa protein", "gene_name": "Snrnp48", "organism": "Mouse", "refseq_name": "U11/U12 small nuclear ribonucleoprotein 48 kDa protein", "refseq_ac": "NP_080658", "gene_names_uniprotkb": "Snrnp48", "gene_names_refseq": "1110050F08Rik; 6530403A03Rik; C6orf151; Snrnp48", "protein_names_uniprotkb": "U11/U12 small nuclear ribonucleoprotein 48 kDa protein; U11/U12 snRNP 48 kDa protein", "protein_names_refseq": "U11/U12 small nuclear ribonucleoprotein 48 kDa protein; U11/U12 snRNP 48 kDa protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:67797); (R-MMU-72165)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18347052;25428506", "class_list": "", "function": "Likely involved in U12-type 5' splice site recognition., [UniProtKB]; Using site-specific cross-linking, we detected an interaction between the U11-48K protein and U12-type 5' splice sites (5'ss)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIU0;Q8BJ30;Q8CFF6;Q8VDQ5;Q9CSG3;Q9CVM5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0034693 U11/U12 snRNP;GO:0005689 U12-type spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D361-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D7Y9-1", "uniprot_id": "SLX4I_MOUSE", "mass": 45736.0, "length": 413, "protein_name": "Protein SLX4IP", "gene_name": "Slx4ip", "organism": "Mouse", "refseq_name": "protein SLX4IP isoform 1", "refseq_ac": "NP_001033730", "gene_names_uniprotkb": "Slx4ip; 2210009G21Rik", "gene_names_refseq": "2210009G21Rik; 2410004I22Rik; Slx4ip; Slxip", "protein_names_uniprotkb": "Protein SLX4IP; SLX4-interacting protein", "protein_names_refseq": "UPF0492 protein C20orf94 homolog; protein SLX4IP isoform 1; protein SLX4IP", "tax_id": 10090, "disease": "", "pathway": " (mmu:74243)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34187905", "class_list": "", "function": "SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-kappaB and Notch signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NXK0;Q9CWT7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D7Y9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8U8-1", "uniprot_id": "SNX5_MOUSE", "mass": 46797.0, "length": 404, "protein_name": "Sorting nexin-5", "gene_name": "Snx5", "organism": "Mouse", "refseq_name": "sorting nexin-5", "refseq_ac": "NP_001186117", "gene_names_uniprotkb": "Snx5", "gene_names_refseq": "0910001N05Rik; 1810032P22Rik; D2Ertd52e; Snx5", "protein_names_uniprotkb": "Sorting nexin-5", "protein_names_refseq": "sorting nexin-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:69178); (R-MMU-432722)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "18854019;30084848;31219806;33118244;33328639;34428180;38950816", "class_list": "", "function": "Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin. Plays a role in the internalization of EGFR after EGF stimulation. Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C and is retromer-independent. Together with PIP5K1C facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation (By similarity). Plays a role in macropinocytosis (PubMed:18854019)., [UniProtKB, UniProtKB, PubMed]; SNX5-Rab11a protects against cardiac hypertrophy through regulating LRP6 membrane translocation., [RefSeq, PubMed]; Sorting nexin 5 mediates virus-induced autophagy and immunity., [RefSeq, PubMed]; Sorting nexin-5 is not required for normal spermatogenesis and male fertilization in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543N9", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0035091 phosphatidylinositol binding;GO:0031748 D1 dopamine receptor binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005768 endosome;GO:0005829 cytosol;GO:0005903 brush border;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045776 negative regulation of blood pressure;GO:0045893 positive regulation of DNA-templated transcription;GO:0042147 retrograde transport, endosome to Golgi;GO:0046628 positive regulation of insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D8U8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERB0-1", "uniprot_id": "SNP29_MOUSE", "mass": 29572.0, "length": 260, "protein_name": "Synaptosomal-associated protein 29", "gene_name": "Snap29", "organism": "Mouse", "refseq_name": "synaptosomal-associated protein 29", "refseq_ac": "NP_075837", "gene_names_uniprotkb": "Snap29", "gene_names_refseq": "1300018G05Rik; Gs32; Snap29", "protein_names_uniprotkb": "Synaptosomal-associated protein 29; Golgi SNARE of 32 kDa; Gs32; SNAP-29; Soluble 29 kDa NSF attachment protein; Vesicle-membrane fusion protein SNAP-29", "protein_names_refseq": "SNAP-29; golgi SNARE of 32 kDa; soluble 29 kDa NSF attachment protein; synaptosomal-associated protein 29; vesicle-membrane fusion protein SNAP-29", "tax_id": 10090, "disease": "CEDNIK syndrome (Disease Ontology:DOID:0060337); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413)", "pathway": " (mmu:67474); (R-MMU-6798695); (R-MMU-6811438)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "19170188;21183079;25428506;26495903;27628032;28011936;32848054;33754017;34428180;36614195", "class_list": "", "function": "Decreased neuronal synaptosome associated protein 29 contributes to poststroke cognitive impairment by disrupting presynaptic maintenance. Publication Status: Online-Only, [RefSeq, PubMed]; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions., [UniProtKB, UniProtKB]; Snap29 Is Dispensable for Self-Renewal Maintenance but Required for Proper Differentiation of Mouse Embryonic Stem Cells. Publication Status: Online-Only, [RefSeq, PubMed]; We suggest that Rab3A may regulate SNAP-29-mediated membrane fusion during myelination., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGN0;Q9DBC5", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9ERB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYZ4-1", "uniprot_id": "SMOK1_MOUSE", "mass": 54794.0, "length": 484, "protein_name": "Sperm motility kinase 1", "gene_name": "Smok1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Smok1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sperm motility kinase 1; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10647005", "class_list": "", "function": "May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QYZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WVB4-1", "uniprot_id": "SLIT3_MOUSE", "mass": 167727.0, "length": 1523, "protein_name": "Slit homolog 3 protein", "gene_name": "Slit3", "organism": "Mouse", "refseq_name": "slit homolog 3 protein precursor", "refseq_ac": "NP_035542", "gene_names_uniprotkb": "Slit3", "gene_names_refseq": "Slil2; Slit1; Slit3; b2b2362.1Clo", "protein_names_uniprotkb": "Slit homolog 3 protein; Slit-3; Slit3", "protein_names_refseq": "slit homolog 3 protein precursor; slit homolog 3 protein; slit-3", "tax_id": 10090, "disease": "congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (mmu:20564); (R-MMU-376176)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10433822;26495903;28011936;30899004;35822049;37830982;38414132", "class_list": "", "function": "May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors., [UniProtKB]; SLIT3-mediated fibroblast signaling: a promising target for antifibrotic therapies. Review article, [RefSeq, PubMed]; Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "B1ATW4", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0005509 calcium ion binding;GO:0048495 Roundabout binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0070100 negative regulation of chemokine-mediated signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0010629 negative regulation of gene expression;GO:0032870 cellular response to hormone stimulus;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9WVB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z199-1", "uniprot_id": "SPT4B_MOUSE", "mass": 13194.0, "length": 117, "protein_name": "Transcription elongation factor SPT4-B", "gene_name": "Supt4h1b", "organism": "Mouse", "refseq_name": "transcription elongation factor SPT4-B", "refseq_ac": "NP_035639", "gene_names_uniprotkb": "Supt4h1b; Gm3258; Supt4b; Supt4h2", "gene_names_refseq": "100041294; Gm3258; Supt4b; Supt4h1b; Supt4h2", "protein_names_uniprotkb": "Transcription elongation factor SPT4-B; DRB sensitivity-inducing factor small subunit 2; DSIF small subunit 2; Transcription elongation factor SPT4 2", "protein_names_refseq": "DRB sensitivity-inducing factor small subunit 2; DSIF small subunit 2; suppressor of Ty 4 homolog 2; suppressor of Ty 4B; transcription elongation factor SPT4 2; transcription elongation factor SPT4-B", "tax_id": 10090, "disease": "", "pathway": " (mmu:100041294)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34428180;9776760", "class_list": "", "function": "Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0032044 DSIF complex", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II;GO:0140673 transcription elongation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z199-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1S5-1", "uniprot_id": "SEPT3_MOUSE", "mass": 40038.0, "length": 350, "protein_name": "Neuronal-specific septin-3", "gene_name": "Septin3", "organism": "Mouse", "refseq_name": "neuronal-specific septin-3 isoform 3", "refseq_ac": "NP_036019", "gene_names_uniprotkb": "Septin3; Sep3; Sept3", "gene_names_refseq": "3110018K01Rik; B530002E20Rik; Gm46500; Sep3; Sept3; Septin3", "protein_names_uniprotkb": "Neuronal-specific septin-3", "protein_names_refseq": "neuronal-specific septin-3 isoform 3; neuronal-specific septin-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:24050)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10446280;17564677;20181826;21750661;33300544", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)., [UniProtKB]; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sept3 is dispensable for normal neuronal development, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNZ2;Q7TNT7", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005940 septin ring;GO:0015630 microtubule cytoskeleton;GO:0042734 presynaptic membrane;GO:0098793 presynapse;GO:0031105 septin complex", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0140247 protein catabolic process at presynapse", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z1S5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64687-1", "uniprot_id": "SIA8A_MOUSE", "mass": 40324.0, "length": 355, "protein_name": "Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase", "gene_name": "St8sia1", "organism": "Mouse", "refseq_name": "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase", "refseq_ac": "NP_035504", "gene_names_uniprotkb": "St8sia1; Siat8a; Siat8", "gene_names_refseq": "9330109E03Rik; GD3S; Sia-T; Siat8a; Siat8; St8sia1", "protein_names_uniprotkb": "Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; 2.4.3.8; Alpha-2,8-sialyltransferase 8A; Ganglioside GD3 synthase; Ganglioside GT3 synthase; SIAT8-A; ST8SiaI; Sialyltransferase 8A; Sialyltransferase St8Sia I", "protein_names_refseq": "SIAT8-A; ST8Sia I; ST8SiaI; alpha-2, 8-sialyltransferase; alpha-2,8-sialyltransferase 8A; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ganglioside GD3 synthase; ganglioside GT3 synthase; sialyltransferase 8 A; sialyltransferase 8A; sialyltransferase St8Sia I; sialytransferase St8Sia I", "tax_id": 10090, "disease": "", "pathway": " (mmu:20449); (R-MMU-4085001)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15843597;21750661;30899004;8910600", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphingolipds that contain one or more residues of sialic acid (PubMed:8910600). Can catalyze the addition of a second alpha-2,8- sialic acid to GD3 to form GT3 (PubMed:8910600). Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (PubMed:8910600)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1C1", "ec_number_list": "2.4.3.-;2.4.99.-;2.4.3.8", "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0008373 sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0006665 sphingolipid metabolic process;GO:0034605 cellular response to heat;GO:0009311 oligosaccharide metabolic process;GO:0006491 N-glycan processing", "synthesized_glycan_count": 21, "hit_score": 1.1, "record_id": "Q64687-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AUV4-1", "uniprot_id": "SMKY_MOUSE", "mass": 57058.0, "length": 508, "protein_name": "Sperm motility kinase Y", "gene_name": "Gm7168", "organism": "Mouse", "refseq_name": "sperm motility kinase Y", "refseq_ac": "NP_001116449", "gene_names_uniprotkb": "Gm7168", "gene_names_refseq": "EG635895; Gm7168", "protein_names_uniprotkb": "Sperm motility kinase Y; 2.7.11.1", "protein_names_refseq": "sperm motility kinase Y", "tax_id": 10090, "disease": "", "pathway": " (mmu:635895)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3B7Y1", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0AUV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BWU1-1", "uniprot_id": "SPRN_MOUSE", "mass": 14591.0, "length": 147, "protein_name": "Shadow of prion protein", "gene_name": "Sprn", "organism": "Mouse", "refseq_name": "shadow of prion protein precursor", "refseq_ac": "NP_898970", "gene_names_uniprotkb": "Sprn; Gm169", "gene_names_refseq": "C630041J07; Sprn", "protein_names_uniprotkb": "Shadow of prion protein; Protein shadoo", "protein_names_refseq": "Shadoo; protein shadoo; shadow of prion protein precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:212518); (R-MMU-163125)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14527721;17199895;17703189;19513788;19685161;21750661;25855735;26721882;31129810;32317725;33713980", "class_list": "", "function": "Co-invalidation of Prnp and Sprn in FVB/N mice affects reproductive performances and highlight complex biological relationship between PrP and Shadoo., [RefSeq, PubMed]; Data suggest that expression of shadoo in neuron or hepatocyte cell lines induces same toxic phenotype of drug hypersensitivity as prion protein/PrP(-central region); this effect is counteracted by co-expression of PrP-wild-type., [RefSeq, PubMed]; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Sho is a candidate for pi, and since it engenders a PrP(C)-like neuroprotective activity, compromised neuroprotective activity resulting from reduced levels exacerbate damage in prion infections., [RefSeq, PubMed]; Sho may play a role in the physiological function of PrP(C) and prion pathogenesis., [RefSeq, PubMed]; Sprn does not play a major role in prion disease incubation time in mice., [RefSeq, PubMed]; The Prion-like protein Shadoo is involved in mouse embryonic and mammary development and differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; These data are indicative of a physiological pathway to access Sho functions in the nucleus under conditions of impaired proteasomal activity., [RefSeq, PubMed]; These observations suggest that Shadoo can affect the prion replication process by (i) acting as a holdase and (ii) interfering with the dominant-negative inhibitor effect of the C1 fragment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BWU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZ28-1", "uniprot_id": "SNF8_MOUSE", "mass": 28886.0, "length": 258, "protein_name": "Vacuolar-sorting protein SNF8", "gene_name": "Snf8", "organism": "Mouse", "refseq_name": "vacuolar-sorting protein SNF8 isoform 1", "refseq_ac": "NP_291046", "gene_names_uniprotkb": "Snf8; D11Moh34", "gene_names_refseq": "D11Moh34; Snf8", "protein_names_uniprotkb": "Vacuolar-sorting protein SNF8; ESCRT-II complex subunit VPS22", "protein_names_refseq": "ESCRT-II complex subunit VPS22; vacuolar-sorting protein SNF8 isoform 1; vacuolar-sorting protein SNF8", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:27681); (R-MMU-917729)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;26495903", "class_list": "", "function": "Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A6M2", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008289 lipid binding;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0000814 ESCRT II complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0071985 multivesicular body sorting pathway;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CZ28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAL0-1", "uniprot_id": "SIM23_MOUSE", "mass": 15821.0, "length": 136, "protein_name": "Small integral membrane protein 23", "gene_name": "Smim23", "organism": "Mouse", "refseq_name": "small integral membrane protein 23", "refseq_ac": "NP_081326", "gene_names_uniprotkb": "Smim23; 1700008A04Rik", "gene_names_refseq": "1700008A04Rik; Smim23", "protein_names_uniprotkb": "Small integral membrane protein 23", "protein_names_refseq": "small integral membrane protein 23; testis specific expressed protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:69351)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DAL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6X942-1", "uniprot_id": "SH24B_MOUSE", "mass": 51120.0, "length": 431, "protein_name": "SH2 domain-containing protein 4B", "gene_name": "Sh2d4b", "organism": "Mouse", "refseq_name": "SH2 domain-containing protein 4B isoform a", "refseq_ac": "NP_808484", "gene_names_uniprotkb": "Sh2d4b", "gene_names_refseq": "A430109M18Rik; D030001E08; Sh2d4b", "protein_names_uniprotkb": "SH2 domain-containing protein 4B", "protein_names_refseq": "SH2 domain-containing protein 4B isoform a; SH2 domain-containing protein 4B", "tax_id": 10090, "disease": "", "pathway": " (mmu:328381)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RSQ7;Q8BQI0", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6X942-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7M7C7-1", "uniprot_id": "SKOR2_MOUSE", "mass": 105616.0, "length": 1008, "protein_name": "SKI family transcriptional corepressor 2", "gene_name": "Skor2", "organism": "Mouse", "refseq_name": "SKI family transcriptional corepressor 2", "refseq_ac": "NP_001103213", "gene_names_uniprotkb": "Skor2; Corl2", "gene_names_refseq": "Corl2; EG664805; Fussel18; Gm7348; Skor2", "protein_names_uniprotkb": "SKI family transcriptional corepressor 2; Fussel-18 homolog; LBX1 corepressor 1-like protein; Ladybird homeobox corepressor 1-like protein; Transcriptional corepressor Corl2", "protein_names_refseq": "LBX1 corepressor 1-like protein; SKI family transcriptional corepressor 2; functional Smad suppressor element on chromosome 18; fussel-18 homolog; ladybird homeobox corepressor 1-like protein; transcriptional corepressor Corl2", "tax_id": 10090, "disease": "nervous system disease (Disease Ontology:DOID:863)", "pathway": " (mmu:664805)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16200078;18522874;21937600;24491816", "class_list": "", "function": "Has transcriptional corepressor activity (PubMed:18522874, PubMed:21937600). In the developing cerebellum, it downregulates BMP signaling resulting in up-regulation of SHH expression in Purkinje cells and promoting their early differentiation (PubMed:21937600, PubMed:24491816). It is also involved in regulating the proliferation of cerebellar granule cell precursors (PubMed:21937600)., [UniProtKB, PubMed, PubMed, PubMed]; Results strongly suggest that Corl2 is a specific marker for Purkinje cells in the cerebellum from their emergence until the adult stage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042826 histone deacetylase binding;GO:0046332 SMAD binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0048814 regulation of dendrite morphogenesis;GO:0021587 cerebellum morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A7M7C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DC77-1", "uniprot_id": "SMPX_MOUSE", "mass": 9253.0, "length": 85, "protein_name": "Small muscular protein", "gene_name": "Smpx", "organism": "Mouse", "refseq_name": "small muscular protein", "refseq_ac": "NP_001239520", "gene_names_uniprotkb": "Smpx; Csl", "gene_names_refseq": "1010001C09Rik; Csl; Smpx", "protein_names_uniprotkb": "Small muscular protein; Chisel protein; Stretch-responsive skeletal muscle protein", "protein_names_refseq": "cardiac and skeletal muscle protein; chisel protein; small muscular protein; stretch-responsive skeletal muscle protein", "tax_id": 10090, "disease": "X-linked deafness 4 (Disease Ontology:DOID:0111735)", "pathway": " (mmu:66106)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10598820;11381084;11401441;21750661", "class_list": "", "function": "In knockout mice, mutates to no overt phenotype. Overexpression in C2C12 cells alters cell shape, migration and responsiveness to IGF signaling., [RefSeq, PubMed]; Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RT38;Q4QRM9;Q8CEX8;Q9ER98", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031430 M band;GO:0043034 costamere;GO:0005927 muscle tendon junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DC77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HKC8-1", "uniprot_id": "SMK3A_MOUSE", "mass": 56487.0, "length": 504, "protein_name": "Sperm motility kinase 3A", "gene_name": "Smok3a", "organism": "Mouse", "refseq_name": "sperm motility kinase 3A", "refseq_ac": "NP_001119517", "gene_names_uniprotkb": "Smok3a", "gene_names_refseq": "Smok2b1; Smok3a", "protein_names_uniprotkb": "Sperm motility kinase 3A; 2.7.11.1", "protein_names_refseq": "sperm motility kinase 2B1; sperm motility kinase 3A; sperm motility kinase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:545814); (mmu:622474)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10647005", "class_list": "", "function": "May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYZ5", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "C0HKC8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HKC9-1", "uniprot_id": "SMK3B_MOUSE", "mass": 56487.0, "length": 504, "protein_name": "Sperm motility kinase 3B", "gene_name": "Smok3b", "organism": "Mouse", "refseq_name": "sperm motility kinase 3B", "refseq_ac": "NP_001034978", "gene_names_uniprotkb": "Smok3b", "gene_names_refseq": "4931427P12Rik; Smok2b2; Smok3b", "protein_names_uniprotkb": "Sperm motility kinase 3B; 2.7.11.1", "protein_names_refseq": "sperm motility kinase 2B; sperm motility kinase 3B; sperm motility kinase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:545814); (mmu:622474)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10647005", "class_list": "", "function": "May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYZ5", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "C0HKC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64685-1", "uniprot_id": "SIAT1_MOUSE", "mass": 46586.0, "length": 403, "protein_name": "Beta-galactoside alpha-2,6-sialyltransferase 1", "gene_name": "St6gal1", "organism": "Mouse", "refseq_name": "beta-galactoside alpha-2,6-sialyltransferase 1", "refseq_ac": "NP_001239434", "gene_names_uniprotkb": "St6gal1; Siat1", "gene_names_refseq": "Siat1; St6Gal-I; St6gal1; St6galI; St6gal", "protein_names_uniprotkb": "Beta-galactoside alpha-2,6-sialyltransferase 1; 2.4.3.1; Alpha 2,6-ST 1; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase 1; ST6Gal I; alpha 2,6-ST 1; beta-galactoside alpha-2,6-sialyltransferase 1", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (mmu:20440); (R-MMU-4085001); (R-MMU-975577); (R-MMU-977068)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "11801660;21750661;22039275;26495903;26740625;34428180;37643018;8081843", "class_list": "glycogene;glycosyltransferase", "function": "ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on chromosome 15. [provided by RefSeq, Nov 2011]., [RefSeq]; Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates (PubMed:22039275). Sialylates complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs confering anti-inflammatory effector functions. Preferentially monosialylates the alpha(1->3) mannose antenna of Fc glycoforms with subsequent disialylation occurring at a much slower rate (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1L1", "ec_number_list": "2.4.3.1", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008373 sialyltransferase activity;GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane;GO:0005797 Golgi medial cisterna", "go_biological_process": "GO:0032946 positive regulation of mononuclear cell proliferation;GO:1900024 regulation of substrate adhesion-dependent cell spreading;GO:0006054 N-acetylneuraminate metabolic process;GO:0050922 negative regulation of chemotaxis;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 1722, "hit_score": 0.9, "record_id": "Q64685-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62189-1", "uniprot_id": "SNRPA_MOUSE", "mass": 31835.0, "length": 287, "protein_name": "U1 small nuclear ribonucleoprotein A", "gene_name": "Snrpa", "organism": "Mouse", "refseq_name": "U1 small nuclear ribonucleoprotein A", "refseq_ac": "NP_001040102", "gene_names_uniprotkb": "Snrpa; Rnu1a-1", "gene_names_refseq": "C430021M15Rik; Rnu1a-1; Rnu1a1; Snrpa; U1-A; U1A", "protein_names_uniprotkb": "U1 small nuclear ribonucleoprotein A; U1 snRNP A; U1-A; U1A", "protein_names_refseq": "U1 small nuclear ribonucleoprotein A; U1 snRNP A; protein A of the U1 small nuclear RNA", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); germ cell cancer (Disease Ontology:DOID:2994); connective tissue disease (Disease Ontology:DOID:65)", "pathway": " (mmu:53607); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "16373497;21750661;24362020;27658936;30767021;34428180;36288343;8415008", "class_list": "", "function": "A new mechanism for regulating SMN levels and provides new insight into the roles of U1A in 3' processing of mRNAs., [RefSeq, PubMed]; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity)., [UniProtKB]; Endogenous non-snRNP associated U1A inhibits poly(A) polymerase activity proportional to U1A recovered, suggesting that available U1A level alone is responsible for changes in its inhibitory effect at the secretory IgM poly (A) site., [RefSeq, PubMed]; SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing., [RefSeq, PubMed]; We found that only the modified U1 snRNA (IVS-AAA) that completely matched both the intronic and exonic U1 binding sequences of the mutated DDC gene could correct splicing errors of either the mutated human DDC minigene or the mouse artificial splicing construct in vitro, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52LA2", "ec_number_list": "", "go_molecular_function": "GO:1990446 U1 snRNP binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0030619 U1 snRNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62189-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5J6-1", "uniprot_id": "SHPK_MOUSE", "mass": 51303.0, "length": 476, "protein_name": "Sedoheptulokinase", "gene_name": "Shpk", "organism": "Mouse", "refseq_name": "sedoheptulokinase", "refseq_ac": "NP_083307", "gene_names_uniprotkb": "Shpk; Carkl", "gene_names_refseq": "4930431K22Rik; Carkl; Shpk", "protein_names_uniprotkb": "Sedoheptulokinase; 2.7.1.14; Carbohydrate kinase-like protein; SHK", "protein_names_refseq": "SHK; carbohydrate kinase-like protein; sedoheptulokinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:74637); (R-MMU-71336)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18775706;21750661;22682222", "class_list": "", "function": "Acts as a modulator of macrophage activation through control of glucose metabolism., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SSE0", "ec_number_list": "2.7.1.14", "go_molecular_function": "GO:0050277 sedoheptulokinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009052 pentose-phosphate shunt, non-oxidative branch;GO:0005975 carbohydrate metabolic process;GO:0071222 cellular response to lipopolysaccharide;GO:0016310 phosphorylation;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D5J6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZU4-1", "uniprot_id": "SMI19_MOUSE", "mass": 12283.0, "length": 107, "protein_name": "Small integral membrane protein 19", "gene_name": "Smim19", "organism": "Mouse", "refseq_name": "small integral membrane protein 19 isoform 1", "refseq_ac": "NP_001012685", "gene_names_uniprotkb": "Smim19; AI316807", "gene_names_refseq": "EST-c39; Smim19", "protein_names_uniprotkb": "Small integral membrane protein 19", "protein_names_refseq": "UPF0697 protein C8orf40 homolog; small integral membrane protein 19 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:102032)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80ZU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RKS2-1", "uniprot_id": "SMIM7_MOUSE", "mass": 8555.0, "length": 75, "protein_name": "Small integral membrane protein 7", "gene_name": "Smim7", "organism": "Mouse", "refseq_name": "small integral membrane protein 7 precursor", "refseq_ac": "NP_765984", "gene_names_uniprotkb": "Smim7; 9130011J15Rik", "gene_names_refseq": "9130011J15Rik; Smim7", "protein_names_uniprotkb": "Small integral membrane protein 7", "protein_names_refseq": "UPF0608 protein C19orf42 homolog; small integral membrane protein 7 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66818)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RKS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64105-1", "uniprot_id": "SPRE_MOUSE", "mass": 27883.0, "length": 261, "protein_name": "Sepiapterin reductase", "gene_name": "Spr", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Spr", "gene_names_refseq": "", "protein_names_uniprotkb": "Sepiapterin reductase; 1.1.1.153; SPR", "protein_names_refseq": "", "tax_id": 10090, "disease": "sepiapterin reductase deficiency (Disease Ontology:DOID:0111168); Parkinson's disease (Disease Ontology:DOID:14330); dystonia (Disease Ontology:DOID:543)", "pathway": " (R-MMU-1474151); (R-MMU-203615)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10209270;21750661;25428506;30084848;34428180;36288343;37453647;37507081;7873607;8304109;8440319;9405351", "class_list": "", "function": "Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63996", "ec_number_list": "2.7.11.12;1.1.1.153", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004757 sepiapterin reductase (NADP+) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0050882 voluntary musculoskeletal movement;GO:0040014 regulation of multicellular organism growth;GO:0042428 serotonin metabolic process;GO:0042417 dopamine metabolic process;GO:0042415 norepinephrine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q64105-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70562-1", "uniprot_id": "SPR2K_MOUSE", "mass": 7499.0, "length": 68, "protein_name": "Small proline-rich protein 2K", "gene_name": "Sprr2k", "organism": "Mouse", "refseq_name": "small proline-rich protein 2K", "refseq_ac": "NP_035607", "gene_names_uniprotkb": "Sprr2k", "gene_names_refseq": "Sprr2k", "protein_names_uniprotkb": "Small proline-rich protein 2K", "protein_names_refseq": "small proline-rich protein 2K", "tax_id": 10090, "disease": "", "pathway": " (mmu:20765)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12584609;15232223;21750661;9888996", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70562-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYZ6-1", "uniprot_id": "SMK2A_MOUSE", "mass": 56787.0, "length": 504, "protein_name": "Sperm motility kinase 2A", "gene_name": "Smok2a", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Smok2a", "gene_names_refseq": "", "protein_names_uniprotkb": "Sperm motility kinase 2A; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:27263)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10647005;21750661;35820727", "class_list": "", "function": "May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QYZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VW3-1", "uniprot_id": "SH3L3_MOUSE", "mass": 10477.0, "length": 93, "protein_name": "SH3 domain-binding glutamic acid-rich-like protein 3", "gene_name": "Sh3bgrl3", "organism": "Mouse", "refseq_name": "SH3 domain-binding glutamic acid-rich-like protein 3", "refseq_ac": "NP_542126", "gene_names_uniprotkb": "Sh3bgrl3", "gene_names_refseq": "1110004L05Rik; Sh3bgrl3", "protein_names_uniprotkb": "SH3 domain-binding glutamic acid-rich-like protein 3", "protein_names_refseq": "SH3 domain-binding glutamic acid-rich-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:73723)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11444877;15120624;21750661;22645316;26495903;26740625;31044023;32152506;36288343", "class_list": "", "function": "Could act as a modulator of glutaredoxin biological activity (By similarity). May play a role in cytoskeleton organization (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0016604 nuclear body;GO:0032587 ruffle membrane", "go_biological_process": "GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91VW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35716-1", "uniprot_id": "SOCS1_MOUSE", "mass": 23715.0, "length": 212, "protein_name": "Suppressor of cytokine signaling 1", "gene_name": "Socs1", "organism": "Mouse", "refseq_name": "suppressor of cytokine signaling 1", "refseq_ac": "NP_001258532", "gene_names_uniprotkb": "Socs1; Cish1; Ssi1", "gene_names_refseq": "Cish1; Cish7; JAB; SOCS-1; SSI-1; Socs1", "protein_names_uniprotkb": "Suppressor of cytokine signaling 1; JAB; JAK-binding protein; SOCS-1; SSI-1; STAT-induced STAT inhibitor 1", "protein_names_refseq": "JAK2-binding protein; STAT-induced STAT inhibitor 1; cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; suppressor of cytokine signaling 1", "tax_id": 10090, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); alcoholic hepatitis (Disease Ontology:DOID:12351); hyperinsulinism (Disease Ontology:DOID:2018); transient cerebral ischemia (Disease Ontology:DOID:224); laryngeal carcinoma (Disease Ontology:DOID:2600); asthma (Disease Ontology:DOID:2841); invasive ductal carcinoma (Disease Ontology:DOID:3008); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); esophageal cancer (Disease Ontology:DOID:5041); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:12703); (R-MMU-6785807); (R-MMU-877300); (R-MMU-877312); (R-MMU-909733); (R-MMU-9705462); (R-MMU-983168)", "pathway_count": 7, "publication_count": 23, "publication_id_list": "10022833;10051596;10064597;10764816;11522790;12163497;12242343;15169905;15522878;22787435;24880459;34428180;38484644;39147013;39197117;39213866;9202125;9202126;9202127;9789053;9826711;9869640;9889194", "class_list": "", "function": "Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:10064597, PubMed:15169905, PubMed:15522878, PubMed:9202125). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity (PubMed:10064597, PubMed:15522878, PubMed:9202125). In vitro, suppresses Tec protein-tyrosine activity (By similarity). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; GDF15 attenuates sepsis-induced myocardial dysfunction by inhibiting cardiomyocytes ferroptosis via the SOCS1/GPX4 signaling pathway., [RefSeq, PubMed]; IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11., [RefSeq, PubMed]; Inflammatory factor-mediated miR-155/SOCS1 signaling axis leads to Treg impairment in systemic lupus erythematosus., [RefSeq, PubMed]; Jun-activated SOCS1 enhances ubiquitination and degradation of CCAAT/enhancer-binding protein beta to ameliorate cerebral ischaemia/reperfusion injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 32, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RT46;O35960;Q3U3L0", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005126 cytokine receptor binding;GO:0019210 kinase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0035556 intracellular signal transduction;GO:0016567 protein ubiquitination;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "O35716-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70554-1", "uniprot_id": "SPR2B_MOUSE", "mass": 10735.0, "length": 98, "protein_name": "Small proline-rich protein 2B", "gene_name": "Sprr2b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sprr2b", "gene_names_refseq": "", "protein_names_uniprotkb": "Small proline-rich protein 2B", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "12584609;15232223;9888996", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSB2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation;GO:0032355 response to estradiol", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70554-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70556-1", "uniprot_id": "SPR2E_MOUSE", "mass": 8406.0, "length": 76, "protein_name": "Small proline-rich protein 2E", "gene_name": "Sprr2e", "organism": "Mouse", "refseq_name": "small proline-rich protein 2E", "refseq_ac": "NP_035601", "gene_names_uniprotkb": "Sprr2e", "gene_names_refseq": "Sprr2e", "protein_names_uniprotkb": "Small proline-rich protein 2E", "protein_names_refseq": "small proline-rich protein 2E", "tax_id": 10090, "disease": "", "pathway": " (mmu:20759)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12584609;15232223;9888996", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0030141 secretory granule;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation;GO:0032355 response to estradiol", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70556-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70558-1", "uniprot_id": "SPR2G_MOUSE", "mass": 8296.0, "length": 76, "protein_name": "Small proline-rich protein 2G", "gene_name": "Sprr2g", "organism": "Mouse", "refseq_name": "small proline-rich protein 2G", "refseq_ac": "NP_001416553", "gene_names_uniprotkb": "Sprr2g", "gene_names_refseq": "Sprr2g", "protein_names_uniprotkb": "Small proline-rich protein 2G", "protein_names_refseq": "small proline-rich protein 2G", "tax_id": 10090, "disease": "", "pathway": " (mmu:20761)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12584609;15232223;9888996", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)., [UniProtKB]; This gene is a member of a tandemly arrayed set of genes that encode small proline-rich proteins, which are involved in epidermal barrier formation and are upregulated under stress conditions. While expression of this gene has been demonstrated, a reference genome insertion would disrupt its open reading frame, and it is thus classified as a transcribed pseudogene. However, transcripts without this insertion have also been described, and these would potentially encode a small proline-rich protein. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation;GO:0032355 response to estradiol", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70558-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88829-1", "uniprot_id": "SIAT9_MOUSE", "mass": 47360.0, "length": 414, "protein_name": "Lactosylceramide alpha-2,3-sialyltransferase", "gene_name": "St3gal5", "organism": "Mouse", "refseq_name": "lactosylceramide alpha-2,3-sialyltransferase isoform a", "refseq_ac": "NP_001030305", "gene_names_uniprotkb": "St3gal5; GM3S; Siat9", "gene_names_refseq": "3S-T; Siat9; St3gal5; [a]2", "protein_names_uniprotkb": "Lactosylceramide alpha-2,3-sialyltransferase; 2.4.3.9; CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; Ganglioside GM3 synthase; ST3Gal V; ST3GalV; Sialyltransferase 9", "protein_names_refseq": "GM3-specific sialytransferase; ST3GalV; ganglioside GM3 synthase; lactosylceramide alpha-2,3-sialyltransferase isoform a; mST3Gal V; sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase)", "tax_id": 10090, "disease": "salt and pepper syndrome (Disease Ontology:DOID:0060470)", "pathway": " (mmu:20454); (R-MMU-4085001); (R-MMU-9840309)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10092602;12629211;16115873;21750661;26740625;30899004;34428180;36335793;37401916;37507081;9875239", "class_list": "glycogene;glycosyltransferase", "function": "(Microbial infection) Gangliosides GD1b and GT1b (derived from GM3) may serve as receptors for some C.botulinum neurotoxins (minimally types BoNT/A, B, C) (PubMed:16115873)., [UniProtKB, PubMed]; GM3 synthase deficiency increases brain glucose metabolism in mice., [RefSeq, PubMed]; Synthetic GM1 improves motor and memory dysfunctions in mice with monoallelic or biallelic disruption of GM3 synthase., [RefSeq, PubMed]; Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis) (PubMed:10092602, PubMed:12629211, PubMed:9875239). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer) (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RRS1;Q3TMT6;Q3TY01;Q91YF2;Q91YF3;Q9CZ65;Q9QWF8;Q9QWF9", "ec_number_list": "2.4.3.9;2.4.3.2;2.4.3.4;2.4.3.6", "go_molecular_function": "GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 412, "hit_score": 2.2, "record_id": "O88829-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06880-1", "uniprot_id": "SOMA_MOUSE", "mass": 24716.0, "length": 216, "protein_name": "Somatotropin", "gene_name": "Gh1", "organism": "Mouse", "refseq_name": "somatotropin precursor", "refseq_ac": "NP_032143", "gene_names_uniprotkb": "Gh1; Gh", "gene_names_refseq": "Gh1; Ghb1; Gh", "protein_names_uniprotkb": "Somatotropin; Growth hormone", "protein_names_refseq": "growth hormone b1; somatotropin precursor; somatotropin", "tax_id": 10090, "disease": "autoimmune polyendocrine syndrome type 1 (Disease Ontology:DOID:0050167); congenital hypothyroidism (Disease Ontology:DOID:0050328); isolated growth hormone deficiency (Disease Ontology:DOID:0060870); isolated growth hormone deficiency type II (Disease Ontology:DOID:0060872); isolated growth hormone deficiency type IA (Disease Ontology:DOID:0060873); isolated growth hormone deficiency type IB (Disease Ontology:DOID:0060874); osteoporosis (Disease Ontology:DOID:11476); gestational diabetes (Disease Ontology:DOID:11714); beta thalassemia (Disease Ontology:DOID:12241); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); anemia (Disease Ontology:DOID:2355); severe acute respiratory syndrome (Disease Ontology:DOID:2945); progeria (Disease Ontology:DOID:3911); myocardial infarction (Disease Ontology:DOID:5844); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetes insipidus (Disease Ontology:DOID:9409); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:14599); (R-MMU-1170546); (R-MMU-422085); (R-MMU-982772)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "2991252;34428180;8647448", "class_list": "", "function": "Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544X1", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0005131 growth hormone receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0031012 extracellular matrix", "go_biological_process": "GO:0071469 cellular response to alkaline pH;GO:0048286 lung alveolus development;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0032355 response to estradiol", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P06880-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07214-1", "uniprot_id": "SPRC_MOUSE", "mass": 34450.0, "length": 302, "protein_name": "SPARC", "gene_name": "Sparc", "organism": "Mouse", "refseq_name": "SPARC precursor", "refseq_ac": "NP_033268", "gene_names_uniprotkb": "Sparc", "gene_names_refseq": "BM-40; ON; Sparc", "protein_names_uniprotkb": "SPARC; BM-40; Basement-membrane protein 40; ON; Osteonectin; Secreted protein acidic and rich in cysteine", "protein_names_refseq": "SPARC precursor; basement-membrane protein 40; osteonectin; secreted protein acidic and rich in cysteine", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); osteogenesis imperfecta type 17 (Disease Ontology:DOID:0110338); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); diabetic angiopathy (Disease Ontology:DOID:11713); calcinosis (Disease Ontology:DOID:182); ovary epithelial cancer (Disease Ontology:DOID:2152); endometrial carcinoma (Disease Ontology:DOID:2871); cervix carcinoma (Disease Ontology:DOID:2893); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); renal cell carcinoma (Disease Ontology:DOID:4450); stomach carcinoma (Disease Ontology:DOID:5517); myocardial infarction (Disease Ontology:DOID:5844); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:20692); (R-MMU-114608); (R-MMU-3000497)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;19542224;21750661;26495903;30899004;3109947;3165375;3410046;3427055;34428180;3755680", "class_list": "glycogene", "function": "Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005518 collagen binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0048752 semicircular canal morphogenesis;GO:0042127 regulation of cell population proliferation;GO:0010595 positive regulation of endothelial cell migration;GO:0030324 lung development;GO:0071363 cellular response to growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P07214-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50404-1", "uniprot_id": "SFTPD_MOUSE", "mass": 37688.0, "length": 374, "protein_name": "Pulmonary surfactant-associated protein D", "gene_name": "Sftpd", "organism": "Mouse", "refseq_name": "pulmonary surfactant-associated protein D precursor", "refseq_ac": "NP_033186", "gene_names_uniprotkb": "Sftpd; Sftp4", "gene_names_refseq": "PSP-D; SP-D; Sfpd; Sftp4; Sftpd", "protein_names_uniprotkb": "Pulmonary surfactant-associated protein D; Lung surfactant protein D; PSP-D; SP-D", "protein_names_refseq": "lung surfactant protein D; pulmonary surfactant-associated protein D precursor; pulmonary surfactant-associated protein D", "tax_id": 10090, "disease": "sinusitis (Disease Ontology:DOID:0050127); pre-malignant neoplasm (Disease Ontology:DOID:0060071); Coronavirus infectious disease (Disease Ontology:DOID:0080599); sarcoidosis (Disease Ontology:DOID:11335); adult respiratory distress syndrome (Disease Ontology:DOID:11394); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); cystic fibrosis (Disease Ontology:DOID:1485); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung non-small cell carcinoma (Disease Ontology:DOID:3908); rhinitis (Disease Ontology:DOID:4483); pneumonia (Disease Ontology:DOID:552); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:20390); (R-MMU-166016); (R-MMU-391160); (R-MMU-5683826); (R-MMU-5686938)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10226065;35874783;38245585;38375572;7499852", "class_list": "glycogene", "function": "Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties., [UniProtKB]; Immunomodulatory Role of Surfactant Protein-D in a Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Model. Publication Status: Online-Only, [RefSeq, PubMed]; Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx., [RefSeq, PubMed]; Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPalpha. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 20, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0001530 lipopolysaccharide binding;GO:0048029 monosaccharide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0005771 multivesicular body", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0043129 surfactant homeostasis;GO:0045087 innate immune response;GO:0048286 lung alveolus development;GO:0007585 respiratory gaseous exchange by respiratory system", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P50404-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70126-1", "uniprot_id": "SIA8E_MOUSE", "mass": 47829.0, "length": 412, "protein_name": "Alpha-2,8-sialyltransferase 8E", "gene_name": "St8sia5", "organism": "Mouse", "refseq_name": "alpha-2,8-sialyltransferase 8E isoform long", "refseq_ac": "NP_038694", "gene_names_uniprotkb": "St8sia5; Siat8e; St8siav", "gene_names_refseq": "ST8SiaV; Siat8e; St8sia5", "protein_names_uniprotkb": "Alpha-2,8-sialyltransferase 8E; 2.4.99.-; SIAT8-E; ST8SiaV; Sialyltransferase 8E; Sialyltransferase St8Sia V", "protein_names_refseq": "SIAT8-E; alpha-2,8-sialyltransferase 8E isoform long; alpha-2,8-sialyltransferase 8E; sialyltransferase 8 (alpha-2, 8-sialyltransferase) E; sialyltransferase St8Sia V; sialytransferase St8Sia V", "tax_id": 10090, "disease": "", "pathway": " (mmu:225742); (R-MMU-4085001); (R-MMU-9840309)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;8910600", "class_list": "glycogene;glycosyltransferase", "function": "Involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, GP1c and GT3 from GD1a, GT1b, GM1b and GD3 respectively., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 11, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QKY5;P70127;P70128", "ec_number_list": "2.4.3.-;2.4.99.-;2.4.3.8", "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0008373 sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0009311 oligosaccharide metabolic process;GO:0006491 N-glycan processing", "synthesized_glycan_count": 21, "hit_score": 0.5, "record_id": "P70126-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97497-1", "uniprot_id": "SHBG_MOUSE", "mass": 44816.0, "length": 403, "protein_name": "Sex hormone-binding globulin", "gene_name": "Shbg", "organism": "Mouse", "refseq_name": "sex hormone-binding globulin precursor", "refseq_ac": "NP_035497", "gene_names_uniprotkb": "Shbg", "gene_names_refseq": "ABP; Shbg", "protein_names_uniprotkb": "Sex hormone-binding globulin; ABP; SBP; SHBG; Sex steroid-binding protein; Testis-specific androgen-binding protein", "protein_names_refseq": "SBP; sex hormone-binding globulin precursor; sex steroid-binding protein; testis-specific androgen-binding protein", "tax_id": 10090, "disease": "endometrial cancer (Disease Ontology:DOID:1380); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:20415)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2753230;30046278;35762039", "class_list": "", "function": "Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity)., [UniProtKB]; SHBG suppresses inflammation and lipid accumulation in macrophages and adipocytes, which might be among the mechanisms underlying the protective effect of SHBG, that is, its actions which reduce the incidence of metabolic syndrome Publication Status: Online-Only, [RefSeq, PubMed]; Transforming growth factor-beta 1: A new factor reducing hepatic SHBG production in liver fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q0VB52", "ec_number_list": "", "go_molecular_function": "GO:0005497 androgen binding;GO:0005496 steroid binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007285 primary spermatocyte growth", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97497-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04892-1", "uniprot_id": "SOX14_MOUSE", "mass": 26515.0, "length": 240, "protein_name": "Transcription factor SOX-14", "gene_name": "Sox14", "organism": "Mouse", "refseq_name": "transcription factor SOX-14", "refseq_ac": "NP_035570", "gene_names_uniprotkb": "Sox14; Sox-14", "gene_names_refseq": "Sox14", "protein_names_uniprotkb": "Transcription factor SOX-14", "protein_names_refseq": "SRY-box containing gene 14; transcription factor SOX-14", "tax_id": 10090, "disease": "intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (mmu:20669)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10677261;10798354;21750661;8441686", "class_list": "", "function": "Acts as a negative regulator of transcription., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLC9;Q9JLD0;Q9QXU4", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q04892-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q148B6-1", "uniprot_id": "SPERI_MOUSE", "mass": 51418.0, "length": 480, "protein_name": "Speriolin", "gene_name": "Spatc1", "organism": "Mouse", "refseq_name": "speriolin", "refseq_ac": "NP_083128", "gene_names_uniprotkb": "Spatc1; Sprn", "gene_names_refseq": "1700084J23Rik; Spatc1; speriolin", "protein_names_uniprotkb": "Speriolin; Spermatogenesis and centriole-associated protein 1; Spermatogenic cell-specific Cdc20-binding protein", "protein_names_refseq": "speriolin; spermatogenesis and centriole-associated protein 1; spermatogenic cell-specific Cdc20-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74281)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15280373;20542897;21750661", "class_list": "", "function": "Determined that speriolin is a spermatogenic cell-specific Cdc20-binding protein, present in cytoplasm, & concentrated at centrosomes of spermatocytes and spermatids; a leucine zipper domain is required to target speriolin to the centrosome [speriolin], [RefSeq, PubMed]; Speriolin is a novel centrosomal protein present in the connecting piece region of mouse sperm that is transmitted to the mouse zygote and can be detected throughout the first mitotic division., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14AS6;Q76MV2;Q9D9F0", "ec_number_list": "", "go_molecular_function": "GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q148B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2MH31-1", "uniprot_id": "SMIP6_MOUSE", "mass": 29939.0, "length": 260, "protein_name": "Sperm microtubule inner protein 6", "gene_name": "Spmip6", "organism": "Mouse", "refseq_name": "sperm microtubule inner protein 6 isoform 1", "refseq_ac": "NP_001041470", "gene_names_uniprotkb": "Spmip6; 1110017D15Rik; C9orf24; Cbe1; Smrp1", "gene_names_refseq": "1110017D15Rik; Cbe1; Smrp1; Spmip6", "protein_names_uniprotkb": "Sperm microtubule inner protein 6; Ciliated bronchial epithelial protein 1; Spermatid-specific manchette-related protein 1; Testis development protein NYD-SP22", "protein_names_refseq": "ciliated bronchial epithelial protein 1; ciliated bronchial epithelium 1; likely ortholog of H. sapiens chromosome 9 open reading frame 24 (C9orf24); sperm microtubule inner protein 6 isoform 1; spermatid-specific manchette-related protein 1; testes development-related NYD-SP22; testis development protein NYD-SP22", "tax_id": 10090, "disease": "", "pathway": " (mmu:73721)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17971504;18163442;19213785;21750661;27357688;31504408;37295417", "class_list": "", "function": "1110017D15Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Chronological regulation of CBE1/Cbe1 expression during pulmonary differentiation suggests involvement in ciliogenesis, with an additional role during early lung development., [RefSeq, PubMed]; Localized to the mitochondria and the contractile ring of dividing inner medullary collecting duct cells; associated with intramanchette transport and midpiece formation of the sperm tail; long isoforms not essential for male fertility, [RefSeq, PubMed]; May participate in intramanchette transport and midpiece formation of the sperm tail (PubMed:31504408). May play a potential role in somatic cell proliferation (PubMed:31504408)., [UniProtKB, PubMed]; SMRP1 was localized to the cytoplasm of step 9-12 elongated spermatids. The protein appeared in a cap formation that covered the caudal sides of the elongated nuclei., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0GC36;Q9D1B3", "ec_number_list": "", "go_molecular_function": "GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q2MH31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TFQ1-1", "uniprot_id": "SPRY7_MOUSE", "mass": 21681.0, "length": 196, "protein_name": "SPRY domain-containing protein 7", "gene_name": "Spryd7", "organism": "Mouse", "refseq_name": "SPRY domain-containing protein 7 isoform 2", "refseq_ac": "NP_001297532", "gene_names_uniprotkb": "Spryd7; Clld6", "gene_names_refseq": "6330409N04Rik; Clld6; Spryd7", "protein_names_uniprotkb": "SPRY domain-containing protein 7; CLL deletion region gene 6 protein homolog; Chronic lymphocytic leukemia deletion region gene 6 protein homolog", "protein_names_refseq": "CLL deletion region gene 6 protein homolog; SPRY domain-containing protein 7 isoform 2; SPRY domain-containing protein 7; chronic lymphocytic leukemia deletion region gene 6 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66674)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25428506;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1Y1;Q9CU44;Q9D368;Q9D3D1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TFQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TUA9-1", "uniprot_id": "SG196_MOUSE", "mass": 39969.0, "length": 349, "protein_name": "Protein O-mannose kinase", "gene_name": "Pomk", "organism": "Mouse", "refseq_name": "protein O-mannose kinase", "refseq_ac": "NP_083313", "gene_names_uniprotkb": "Pomk; Sgk196", "gene_names_refseq": "4930444A02Rik; Pomk; Sgk196", "protein_names_uniprotkb": "Protein O-mannose kinase; 2.7.1.183; POMK; Protein kinase-like protein SgK196; Sugen kinase 196", "protein_names_refseq": "probable inactive protein kinase-like protein SgK196; protein O-mannose kinase; sugen kinase 196", "tax_id": 10090, "disease": "congenital muscular dystrophy-dystroglycanopathy type A12 (Disease Ontology:DOID:0111235); muscular dystrophy-dystroglycanopathy type C12 (Disease Ontology:DOID:0112381); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:74653); (R-MMU-8932505)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21746835;28251761;31219806;32975514;34428180;36210013", "class_list": "glycan-modifying enzyme;glycogene", "function": "Congenital hydrocephalus and defective neuronal migration in cerebellar development in 4930444A02Rik mice, [RefSeq, PubMed]; POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan. Publication Status: Online-Only, [RefSeq, PubMed]; Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif (By similarity)., [UniProtKB]; Study elucidated the atomic structure of mouse POMK catalytic domain in both the absence and presence of donor and acceptor substrates., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBZ0;Q8BZ83;Q8R2S2;Q9D5G4", "ec_number_list": "2.7.1.183", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0019200 carbohydrate kinase activity;GO:0016773 phosphotransferase activity, alcohol group as acceptor", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007611 learning or memory;GO:0050905 neuromuscular process;GO:0006493 protein O-linked glycosylation;GO:0019233 sensory perception of pain;GO:0007420 brain development", "synthesized_glycan_count": 17, "hit_score": 0.7, "record_id": "Q3TUA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V0X1-1", "uniprot_id": "SMIM9_MOUSE", "mass": 15398.0, "length": 137, "protein_name": "Small integral membrane protein 9", "gene_name": "Smim9", "organism": "Mouse", "refseq_name": "small integral membrane protein 9 precursor", "refseq_ac": "NP_001028958", "gene_names_uniprotkb": "Smim9", "gene_names_refseq": "4930428E23Rik; Smim9", "protein_names_uniprotkb": "Small integral membrane protein 9", "protein_names_refseq": "small integral membrane protein 9 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:434800)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3V0X1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DTW2-1", "uniprot_id": "SMBT2_MOUSE", "mass": 105981.0, "length": 938, "protein_name": "Scm-like with four MBT domains protein 2", "gene_name": "Sfmbt2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sfmbt2; Kiaa1617", "gene_names_refseq": "", "protein_names_uniprotkb": "Scm-like with four MBT domains protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "12466296;18024232;31219806", "class_list": "", "function": "Transcriptional repressor of HOXB13 gene., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VG7", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5DTW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJH6-1", "uniprot_id": "SMG7_MOUSE", "mass": 126841.0, "length": 1138, "protein_name": "Nonsense-mediated mRNA decay factor SMG7", "gene_name": "Smg7", "organism": "Mouse", "refseq_name": "nonsense-mediated mRNA decay factor SMG7 isoform 3", "refseq_ac": "NP_001005507", "gene_names_uniprotkb": "Smg7; Est1c; Kiaa0250", "gene_names_refseq": "9430023P16Rik; Smg7; mKIAA0250", "protein_names_uniprotkb": "Nonsense-mediated mRNA decay factor SMG7; SMG-7 homolog", "protein_names_refseq": "EST1-like protein C; Smg-7 homolog, nonsense mediated mRNA decay factor; nonsense-mediated mRNA decay factor SMG7 isoform 3; nonsense-mediated mRNA decay factor SMG7; protein SMG7", "tax_id": 10090, "disease": "", "pathway": " (mmu:226517); (R-MMU-975957)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;10.3389/fragi.2021.757801;22645316;25428506;30084848;30779550;31599954;32782141;32848054;34203471;34428180;34678516;35822049;36852467;37349371;40885482", "class_list": "", "function": "Characterization of a rhabdomyosarcoma reveals a critical role for SMG7 in cancer cell viability and tumor growth. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q63ZW5;Q6ZQF3", "ec_number_list": "", "go_molecular_function": "GO:0042162 telomeric DNA binding;GO:0051721 protein phosphatase 2A binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q5RJH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TNE3-1", "uniprot_id": "SPAG7_MOUSE", "mass": 25921.0, "length": 227, "protein_name": "Sperm-associated antigen 7", "gene_name": "Spag7", "organism": "Mouse", "refseq_name": "sperm-associated antigen 7 isoform 2", "refseq_ac": "NP_001161141", "gene_names_uniprotkb": "Spag7", "gene_names_refseq": "5730443G10; ACRP; FSA-1; Fsa1l; Spag7", "protein_names_uniprotkb": "Sperm-associated antigen 7", "protein_names_refseq": "sperm-associated antigen 7 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:216873)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19144319;21183079;21750661;22517741;25428506;25605945;28135057;28528544;30084848;32848054;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TM27;Q80XJ8;Q8BK16", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q7TNE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61711-1", "uniprot_id": "SIAL_MOUSE", "mass": 35734.0, "length": 324, "protein_name": "Integrin-binding sialoprotein", "gene_name": "Ibsp", "organism": "Mouse", "refseq_name": "integrin-binding sialoprotein precursor", "refseq_ac": "NP_032344", "gene_names_uniprotkb": "Ibsp", "gene_names_refseq": "BSP II; BSPII; BSP; Bsp2; Ibsp", "protein_names_uniprotkb": "Integrin-binding sialoprotein; BSP II; Bone sialoprotein 2; Bone sialoprotein II; Cell-binding sialoprotein", "protein_names_refseq": "bone sialoprotein 2; bone sialoprotein II; cell-binding sialoprotein; integrin-binding sialoprotein precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:15891); (R-MMU-216083)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "20485683;8180469", "class_list": "", "function": "Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes adhesion and migration of various cells via the alpha-V/beta-3 integrin receptor (ITGAV:ITGB3)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q61363;Q80VR6", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0036094 small molecule binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031982 vesicle", "go_biological_process": "GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0045785 positive regulation of cell adhesion;GO:0071363 cellular response to growth factor stimulus;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q61711-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62249-1", "uniprot_id": "SOX19_MOUSE", "mass": 6862.0, "length": 55, "protein_name": "Protein SOX-19", "gene_name": "Sox19", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sox19", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein SOX-19", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q62249-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P069-1", "uniprot_id": "SORCN_MOUSE", "mass": 21627.0, "length": 198, "protein_name": "Sorcin", "gene_name": "Sri", "organism": "Mouse", "refseq_name": "sorcin isoform 1", "refseq_ac": "NP_001074443", "gene_names_uniprotkb": "Sri", "gene_names_refseq": "2210417O06Rik; 2900070H08Rik; Sor; Sri", "protein_names_uniprotkb": "Sorcin", "protein_names_refseq": "sorcin isoform 1", "tax_id": 10090, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:109552); (R-MMU-2672351); (R-MMU-418359); (R-MMU-425561); (R-MMU-5578775); (R-MMU-936837)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "12824171;24427308;29174767;29273681;31309533;33675811", "class_list": "", "function": "Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels., [UniProtKB, PubMed]; Knockdown of sorcin increases HEI-OC1 cell damage induced by cisplatin in vitro., [RefSeq, PubMed]; Presence of Pb(2+) ions within the hepatocytes reduces transcript and protein levels of sorcin, a cytosolic adaptor partner of ChREBP. Adenovirus-mediated overexpression of sorcin in Pb(2+) exposed hepatocytes and an in vivo mouse model ameliorates liver steatosis and hepatotoxicity. These results present evidence that sorcin is an essential regulator of Pb2+-induced dyslipidemia in the liver., [RefSeq, PubMed]; Sorcin deficiency may trigger cardiac ventricular arrhythmias due to Ca(2+) disturbances, [RefSeq, PubMed]; Sorcin is a potent inhibitor of both spontaneous and ICa-triggered RyR activity and is kinetically capable of playing a role in terminating the positive feedback loop of Ca2+-induced Ca2+ release, [RefSeq, PubMed]; Sorcin is involved in the regulation of Ca(+2)-mediated angiogenesis via VEGF/PI3K/Akt pathway in endometrial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKC5;Q9CR38;Q9D7V8", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0006816 calcium ion transport;GO:0051924 regulation of calcium ion transport;GO:0055118 negative regulation of cardiac muscle contraction;GO:0010459 negative regulation of heart rate;GO:0051281 positive regulation of release of sequestered calcium ion into cytosol", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6P069-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P4P1-1", "uniprot_id": "SPA3A_MOUSE", "mass": 47772.0, "length": 422, "protein_name": "Serine protease inhibitor A3A", "gene_name": "Serpina3a", "organism": "Mouse", "refseq_name": "serine protease inhibitor A3A isoform 2", "refseq_ac": "NP_083016", "gene_names_uniprotkb": "Serpina3a", "gene_names_refseq": "Serpina3a", "protein_names_uniprotkb": "Serine protease inhibitor A3A; Serpin A3A", "protein_names_refseq": "serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3A; serine protease inhibitor A3A isoform 2; serine protease inhibitor A3A; serpin A3A", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); cystic fibrosis (Disease Ontology:DOID:1485); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); vasculitis (Disease Ontology:DOID:865)", "pathway": " (mmu:74069)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12659817;15638460;21750661;30084848", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9D490", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0034097 response to cytokine", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P4P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TMX5-1", "uniprot_id": "SHQ1_MOUSE", "mass": 63458.0, "length": 569, "protein_name": "Protein SHQ1 homolog", "gene_name": "Shq1", "organism": "Mouse", "refseq_name": "protein SHQ1 homolog", "refseq_ac": "NP_853621", "gene_names_uniprotkb": "Shq1", "gene_names_refseq": "2810403P18Rik; Grim-1; Shq1", "protein_names_uniprotkb": "Protein SHQ1 homolog", "protein_names_refseq": "protein SHQ1 homolog", "tax_id": 10090, "disease": "dystonia 35, childhood-onset (Disease Ontology:DOID:0060955)", "pathway": " (mmu:72171); (R-MMU-171319)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0060765 regulation of androgen receptor signaling pathway;GO:0022618 protein-RNA complex assembly;GO:0000493 box H/ACA snoRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TMX5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80X76-1", "uniprot_id": "SPA3F_MOUSE", "mass": 50003.0, "length": 445, "protein_name": "Serine protease inhibitor A3F", "gene_name": "Serpina3f", "organism": "Mouse", "refseq_name": "serine protease inhibitor A3F", "refseq_ac": "NP_001028507", "gene_names_uniprotkb": "Serpina3f", "gene_names_refseq": "2A1; Serpina3f", "protein_names_uniprotkb": "Serine protease inhibitor A3F; Serpin A3F", "protein_names_refseq": "alpha-1 antiproteinasin; antitrypsin; serine protease inhibitor A3F; serpin A3F", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); cystic fibrosis (Disease Ontology:DOID:1485); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); vasculitis (Disease Ontology:DOID:865)", "pathway": " (mmu:238393)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;12659817;15638460;16944957", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B2RT49", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0009617 response to bacterium;GO:0034097 response to cytokine;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80X76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810K3-1", "uniprot_id": "SGPP2_MOUSE", "mass": 40248.0, "length": 354, "protein_name": "Sphingosine-1-phosphate phosphatase 2", "gene_name": "Sgpp2", "organism": "Mouse", "refseq_name": "sphingosine-1-phosphate phosphatase 2", "refseq_ac": "NP_001004173", "gene_names_uniprotkb": "Sgpp2", "gene_names_refseq": "SPPase2; Sgpp2; Spp2", "protein_names_uniprotkb": "Sphingosine-1-phosphate phosphatase 2; 3.1.3.-; SPPase2; Sphingosine-1-phosphatase 2; Spp2", "protein_names_refseq": "sphingosine-1-phosphatase 2; sphingosine-1-phosphate phosphatase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:433323); (R-MMU-9845614)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19073640;27059959;30084848", "class_list": "glycogene", "function": "Data indicate that beta-cells from untreated sphingosine-1-phosphate phosphotase 2 knockout Sgpp2(-/-) mice showed significantly increased expression of proteins characteristic of the endoplasmic reticulum stress response, indicating a basal islet defect., [RefSeq, PubMed]; Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (Probable). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (By similarity). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (PubMed:27059959)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RWL5", "ec_number_list": "3.1.3.-;3.1.3.4;3.1.3.106;3.6.1.75", "go_molecular_function": "GO:0070780 dihydrosphingosine-1-phosphate phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0061469 regulation of type B pancreatic cell proliferation;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q810K3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q811W0-1", "uniprot_id": "SOX21_MOUSE", "mass": 28610.0, "length": 276, "protein_name": "Transcription factor SOX-21", "gene_name": "Sox21", "organism": "Mouse", "refseq_name": "transcription factor SOX-21", "refseq_ac": "NP_808421", "gene_names_uniprotkb": "Sox21", "gene_names_refseq": "Sox21; Sox25", "protein_names_uniprotkb": "Transcription factor SOX-21", "protein_names_refseq": "DNA-binding protein SOX21; HMG-box protein SOX21; SRY-box containing gene 21; transcription factor SOX-21", "tax_id": 10090, "disease": "intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (mmu:223227)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12446692;15039105;34812512", "class_list": "", "function": "May play a role as an activator of transcription of OPRM1 (PubMed:12446692). Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells (PubMed:12446692). May play a role in ameloblast differentiation (PubMed:34812512)., [UniProtKB, PubMed, PubMed]; Overexpression of Sox21 results in a substantial repression of NGF-induced neurite outgrowth in PC12 cells. Y-box binding protein 1 not only binds to Sox21 but also partially restores NGF-induced neurite outgrowth of PC12 cells inhibited by Sox21., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJU0;Q8VH35", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q811W0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGT7-1", "uniprot_id": "SPF30_MOUSE", "mass": 26753.0, "length": 238, "protein_name": "Survival of motor neuron-related-splicing factor 30", "gene_name": "Smndc1", "organism": "Mouse", "refseq_name": "survival of motor neuron-related-splicing factor 30 isoform 1", "refseq_ac": "NP_766017", "gene_names_uniprotkb": "Smndc1; Smnr; Spf30", "gene_names_refseq": "Smndc1", "protein_names_uniprotkb": "Survival of motor neuron-related-splicing factor 30; 30 kDa splicing factor SMNrp; SMN-related protein; Survival motor neuron domain-containing protein 1", "protein_names_refseq": "30 kDa splicing factor SMNrp; SMN-related protein; survival motor neuron domain-containing protein 1; survival of motor neuron-related-splicing factor 30 isoform 1; survival of motor neuron-related-splicing factor 30", "tax_id": 10090, "disease": "", "pathway": " (mmu:76479); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26495903;28612854;30084848;31219806;34428180;36044849;39150991", "class_list": "", "function": "An autoregulatory poison exon in Smndc1 is conserved across kingdoms and influences organism growth. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in spliceosome assembly (By similarity)., [UniProtKB, UniProtKB]; SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression., [RefSeq, PubMed]; The results show that SMNDC1 mRNA 5'-UTR forms an intramolecular, parallel G quadruplex structure comprised of three G quartet planes, which is bound specifically by FMRP both in vitro and in mouse brain lysates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQL0", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006915 apoptotic process;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BGT7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIZ6-1", "uniprot_id": "SNIP1_MOUSE", "mass": 44415.0, "length": 383, "protein_name": "Smad nuclear-interacting protein 1", "gene_name": "Snip1", "organism": "Mouse", "refseq_name": "smad nuclear-interacting protein 1 isoform 1", "refseq_ac": "NP_780455", "gene_names_uniprotkb": "Snip1", "gene_names_refseq": "2410133M08Rik; Snip1", "protein_names_uniprotkb": "Smad nuclear-interacting protein 1", "protein_names_refseq": "Smad nuclear interacting protein 1 Snip1; smad nuclear-interacting protein 1 isoform 1; smad nuclear-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76793); (R-MMU-72163)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17242355;19144319;21183079;38309408", "class_list": "", "function": "LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding to SENP1 to promote intestinal fibrosis in Crohn's disease., [RefSeq, PubMed]; Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V106;Q8BIZ4", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0035196 miRNA processing;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BIZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BT42-1", "uniprot_id": "SMIM5_MOUSE", "mass": 8529.0, "length": 78, "protein_name": "Small integral membrane protein 5", "gene_name": "Smim5", "organism": "Mouse", "refseq_name": "small integral membrane protein 5", "refseq_ac": "NP_899082", "gene_names_uniprotkb": "Smim5", "gene_names_refseq": "2210020M01Rik; Smim5", "protein_names_uniprotkb": "Small integral membrane protein 5", "protein_names_refseq": "small integral membrane protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:66528)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BT42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BUE1-1", "uniprot_id": "SL9A4_MOUSE", "mass": 90937.0, "length": 797, "protein_name": "Sodium/hydrogen exchanger 4", "gene_name": "Slc9a4", "organism": "Mouse", "refseq_name": "sodium/hydrogen exchanger 4 precursor", "refseq_ac": "NP_796058", "gene_names_uniprotkb": "Slc9a4; Nhe4", "gene_names_refseq": "D730009J23Rik; NHE4; Slc9a4", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 4; NHE-4; Na(+)/H(+) exchanger 4; Solute carrier family 9 member 4", "protein_names_refseq": "NHE-4; Na(+)/H(+) exchanger 4; sodium/hydrogen exchanger 4 precursor; sodium/hydrogen exchanger 4; solute carrier family 9 member 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:110895); (R-MMU-425986)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10666043;11880326;12493726;15684419;20484819;22872234;32372285;9691122", "class_list": "", "function": "Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (PubMed:15684419, PubMed:20484819). As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (PubMed:20484819). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (PubMed:15684419). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (PubMed:32372285)., [UniProtKB, PubMed, PubMed, PubMed]; SLC9A4 in the organum vasculosum of the lamina terminalis is a [Na(+)] sensor for the control of water intake., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCU9;Q9WUJ6", "ec_number_list": "", "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0042589 zymogen granule membrane", "go_biological_process": "GO:0070634 transepithelial ammonium transport;GO:0001696 gastric acid secretion;GO:0051453 regulation of intracellular pH;GO:0071805 potassium ion transmembrane transport;GO:0002064 epithelial cell development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BUE1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C120-1", "uniprot_id": "SH3R3_MOUSE", "mass": 93130.0, "length": 878, "protein_name": "E3 ubiquitin-protein ligase SH3RF3", "gene_name": "Sh3rf3", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase SH3RF3", "refseq_ac": "NP_766376", "gene_names_uniprotkb": "Sh3rf3; Posh2; Sh3md4", "gene_names_refseq": "4831416G18Rik; Igfbp5-ip; Sh3md4; Sh3rf31; Sh3rf3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SH3RF3; 2.3.2.27; Plenty of SH3s 2; SH3 domain-containing RING finger protein 3; SH3 multiple domains protein 4", "protein_names_refseq": "E3 ubiquitin-protein ligase SH3RF3; SH3 domain-containing RING finger protein 3; SH3 multiple domains 4; SH3 multiple domains protein 4; insulin-like growth factor binding protein 5 interacting protein; plenty of SH3s 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:237353)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16269403;17823924;22517741;25428506;32848054;34678516;35820727;40885482", "class_list": "", "function": "Androgen suppressive therapy increases IGFBP5 in the bone marrow microenvironment and thereby may facilitate the progression of prostate cancer., [RefSeq, PubMed]; Has E3 ubiquitin-protein ligase activity., [UniProtKB, UniProtKB]; Insulin-like growth factor binding protein 5 interacting protein (IGFBP5-IP) may act as intracellular mediator of growth promoting actions of IGFBP5 and perhaps other osteoregulatory agents in bone cells., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0K8;Q3V0Q0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8C120-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C1Q6-1", "uniprot_id": "UQCC5_MOUSE", "mass": 9746.0, "length": 80, "protein_name": "Ubiquinol-cytochrome c reductase complex assembly factor 5", "gene_name": "Uqcc5", "organism": "Mouse", "refseq_name": "ubiquinol-cytochrome c reductase complex assembly factor 5 isoform 2", "refseq_ac": "NP_001295020", "gene_names_uniprotkb": "Uqcc5; Smim4", "gene_names_refseq": "2010107H07Rik; Gm41122; Smim4; Uqcc5", "protein_names_uniprotkb": "Ubiquinol-cytochrome c reductase complex assembly factor 5; Small integral membrane protein 4; Small nucleolar RNA host gene 8", "protein_names_refseq": "small integral membrane protein 4; small nucleolar RNA host gene 8; ubiquinol-cytochrome c reductase complex assembly factor 5 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66487)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34428180;35977508", "class_list": "", "function": "Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:35977508). Mediates early complex III biogenesis (PubMed:35977508). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (PubMed:35977508). Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ92;Q8C1P1", "ec_number_list": "", "go_molecular_function": "GO:0097177 mitochondrial ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0034551 mitochondrial respiratory chain complex III assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C1Q6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C5U4-1", "uniprot_id": "SPEM2_MOUSE", "mass": 56934.0, "length": 503, "protein_name": "Uncharacterized protein SPEM2", "gene_name": "Spem2", "organism": "Mouse", "refseq_name": "uncharacterized protein SPEM2", "refseq_ac": "NP_780577", "gene_names_uniprotkb": "Spem2", "gene_names_refseq": "4933402P03Rik; Spem2", "protein_names_uniprotkb": "Uncharacterized protein SPEM2", "protein_names_refseq": "uncharacterized protein C17orf74 homolog; uncharacterized protein SPEM2", "tax_id": 10090, "disease": "", "pathway": " (mmu:108803)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38421455", "class_list": "", "function": "Spem2, a novel testis-enriched gene, is required for spermiogenesis and fertilization in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C5U4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CA71-1", "uniprot_id": "SHSA4_MOUSE", "mass": 21483.0, "length": 197, "protein_name": "Protein shisa-4", "gene_name": "Shisa4", "organism": "Mouse", "refseq_name": "protein shisa-4 precursor", "refseq_ac": "NP_780468", "gene_names_uniprotkb": "Shisa4; Tmem58", "gene_names_refseq": "9330132O05Rik; Shisa4; Tmem58; mShisa4", "protein_names_uniprotkb": "Protein shisa-4; Transmembrane protein 58", "protein_names_refseq": "protein shisa-4 precursor; protein shisa-4; shisa homolog 4; transmembrane protein 58", "tax_id": 10090, "disease": "", "pathway": " (mmu:77552)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CA71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CEK3-1", "uniprot_id": "SPIKL_MOUSE", "mass": 10542.0, "length": 90, "protein_name": "Serine protease inhibitor kazal-like protein, minor form", "gene_name": "Spinkl", "organism": "Mouse", "refseq_name": "serine protease inhibitor kazal-like protein, minor form precursor", "refseq_ac": "NP_898946", "gene_names_uniprotkb": "Spinkl", "gene_names_refseq": "9530002K18Rik; Spinkl", "protein_names_uniprotkb": "Serine protease inhibitor kazal-like protein, minor form; SPINKL, minor form", "protein_names_refseq": "SPINKL, minor form; serine protease inhibitor kazal-like protein, minor form precursor; serine protease inhibitor kazal-like protein, minor form", "tax_id": 10090, "disease": "", "pathway": " (mmu:77424)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;18715980;23097296", "class_list": "", "function": "Does not function as an inhibitor of trypsin, chymotrypsin, subtilisin or elastase. Binds sperm and enhances sperm motility. May act as a decapacitation factor, suppresses BSA-stimulated sperm capacitation and blocks sperm-oocyte interactions in vitro., [UniProtKB, PubMed]; SPINKL's binding to ejaculated sperm in the uterus but not in the oviduct suggest that SPINKL serves as a sperm protector in the uterus by preventing premature capacitation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1902491 negative regulation of sperm capacitation;GO:1902093 positive regulation of flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CEK3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1S6-1", "uniprot_id": "SPIR2_MOUSE", "mass": 80210.0, "length": 718, "protein_name": "Protein spire homolog 2", "gene_name": "Spire2", "organism": "Mouse", "refseq_name": "protein spire homolog 2", "refseq_ac": "NP_758491", "gene_names_uniprotkb": "Spire2; spir-2", "gene_names_refseq": "Spir-2; Spir2; Spire2", "protein_names_uniprotkb": "Protein spire homolog 2; Spir-2", "protein_names_refseq": "protein spire homolog 2; spire homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:234857)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;15053972;20723621;21183079;21620703;21983562;23577770;27623148;30557038;31219806", "class_list": "", "function": "Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:21620703, PubMed:21983562). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:21983562). Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; After injection of double-strand RNA against Spire 1 and 2 (Spire1+2 double-strand RNA), actin mesh levels were significantly decreased compared with that of control (negative). Conserved zinc-binding cysteines in the FYVE domain of Spire2 are crucial for proper localization in the oocyte cortex and cytoplasmic vesicles. The interaction between FMN2 and Spire2 proteins does not affect localization of Spire2., [RefSeq, PubMed]; Spir-2 is found to be expressed as a single mRNA in the developing nervous system and intestine. In adult mouse it is expressed in epithelial cells of the digestive tract, in neuronal cells of the nervous system, and in testical spermatocytes., [RefSeq, PubMed]; Spire1 and Spire2 drive two critical steps of asymmetric oocyte division, [RefSeq, PubMed]; The authors determined crystal structures of MyoVa-globular tail domain bound either to the Spir-2 motif or to Rab11 and show that a Spir-2:MyoVa:Rab11 complex can form. Publication Status: Online-Only, [RefSeq, PubMed]; We describe a novel locus, called Streptococcus pneumoniae infection resistance 2 (Spir2) on Chr4, which influences time to morbidity and the development of bacteraemia post-infection. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0R2", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0030036 actin cytoskeleton organization;GO:0016192 vesicle-mediated transport;GO:0051639 actin filament network formation;GO:0046907 intracellular transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K1S6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R216-1", "uniprot_id": "SIR4_MOUSE", "mass": 37525.0, "length": 333, "protein_name": "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial", "gene_name": "Sirt4", "organism": "Mouse", "refseq_name": "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial", "refseq_ac": "NP_001161163", "gene_names_uniprotkb": "Sirt4; Sir2l4", "gene_names_refseq": "4930596O17Rik; Sirt4", "protein_names_uniprotkb": "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; 2.3.1.-; 2.3.1.286; 2.4.2.-; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein biotinylase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; Regulatory protein SIR2 homolog 4; SIR2-like protein 4", "protein_names_refseq": "NAD-dependent protein biotinylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (mmu:75387); (R-MMU-204174); (R-MMU-2151201)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "16959562;16959573;19220062;20685656;23438705;23562301;23663782;23746352;24043310;25525879;31219806;38385071;38507411;38586875;39495216", "class_list": "", "function": "Acts as a NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase (PubMed:19220062). Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation (PubMed:23663782). Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (PubMed:23746352). Does not seem to deacetylate PC (PubMed:23438705). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels (PubMed:20685656, PubMed:24043310). Down-regulates insulin secretion (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed]; Controls insulin secretion in pancreatic beta cells; also transfers an ADP-ribosyl group from NAD to histones, [RefSeq, PubMed]; Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2. Publication Status: Online-Only, [RefSeq, PubMed]; SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis., [RefSeq, PubMed]; SIRT4 promotes neuronal apoptosis in models of Alzheimer's disease via the STAT2-SIRT4-mTOR pathway., [RefSeq, PubMed]; Sirtuin 4 (Sirt4) downregulation contributes to chondrocyte senescence and osteoarthritis via mediating mitochondrial dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3Z1D9", "ec_number_list": "1.4.1.3;2.4.2.-;2.3.1.-;2.3.1.286;2.3.1.12", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070403 NAD+ binding;GO:0004407 histone deacetylase activity;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0046322 negative regulation of fatty acid oxidation;GO:0046889 positive regulation of lipid biosynthetic process;GO:0071456 cellular response to hypoxia;GO:0006974 DNA damage response;GO:0046676 negative regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8R216-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VI51-1", "uniprot_id": "SORC3_MOUSE", "mass": 135985.0, "length": 1219, "protein_name": "VPS10 domain-containing receptor SorCS3", "gene_name": "Sorcs3", "organism": "Mouse", "refseq_name": "VPS10 domain-containing receptor SorCS3 precursor", "refseq_ac": "NP_079972", "gene_names_uniprotkb": "Sorcs3", "gene_names_refseq": "6330404A12Rik; Sorcs3", "protein_names_uniprotkb": "VPS10 domain-containing receptor SorCS3", "protein_names_refseq": "VPS10 domain-containing receptor SorCS3 precursor; VPS10 domain-containing receptor SorCS3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66673)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;15009648;24069373;24715575;27935149;29440124;30899004;31095505;33300544", "class_list": "", "function": "Our findings identified a novel role for VPS10P domain receptors SORCS1 and SORCS3 in hypothalamic control of metabolism through regulation of orexigenic peptide production., [RefSeq, PubMed]; Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localization of AMPA-type glutamate receptors in the postsynaptic density., [UniProtKB, PubMed, PubMed]; SorCS1 and SorLA expression were markedly reduced in the frontal cerebral cortex and to a minor extent in the hippocampus, whereas SorCS3 expression was solely reduced in the frontal cerebral cortex, [RefSeq, PubMed]; SorCS3 and the homologous sorCS1 and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 did not require protein synthesis, [RefSeq, PubMed]; SorCS3 serves as a key regulator of synaptic transmission and plasticity. Results show that glutamate receptor functions are controlled by SorCS3 to secure correct functioning of excitatory synapses. The receptor plays a more central role in CA1 compared to the dentate gyrus, correlating well with the expression pattern. Reduced function of SorCS3 results in impaired synaptic mechanisms in the hippocampus., [RefSeq, PubMed]; Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. Publication Status: Online-Only, [RefSeq, PubMed]; Study demonstrates that SorCS3 expression is restricted to the developing and adult nervous system, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTR4", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:0007612 learning;GO:0007613 memory;GO:0015031 protein transport;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8VI51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91V61-1", "uniprot_id": "SFXN3_MOUSE", "mass": 35406.0, "length": 321, "protein_name": "Sideroflexin-3", "gene_name": "Sfxn3", "organism": "Mouse", "refseq_name": "sideroflexin-3 isoform 2", "refseq_ac": "NP_001171483", "gene_names_uniprotkb": "Sfxn3", "gene_names_refseq": "Sfxn3", "protein_names_uniprotkb": "Sideroflexin-3", "protein_names_refseq": "sideroflexin-3 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:94280)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11274051;15864810;19372376;21750661;24788674;28049716;29187734;32457148;33300544;34428180;35092170", "class_list": "", "function": "Citrate transporter protein-like protein/Sfxn3 and some other family members might be important in the differentiation of pancreatic beta-cells, [RefSeq, PubMed]; Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice., [RefSeq, PubMed]; Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~80%., [RefSeq, PubMed]; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sideroflexin 3 (SFXN3) was found to be a mitochondrial protein localized to the inner mitochondrial membrane., [RefSeq, PubMed]; The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q544M7;Q8C1Z2", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015194 L-serine transmembrane transporter activity;GO:0015075 monoatomic ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:1990542 mitochondrial transmembrane transport;GO:0140300 serine import into mitochondrion;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q91V61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JR1-1", "uniprot_id": "SFXN1_MOUSE", "mass": 35649.0, "length": 322, "protein_name": "Sideroflexin-1", "gene_name": "Sfxn1", "organism": "Mouse", "refseq_name": "sideroflexin-1 isoform 1", "refseq_ac": "NP_081600", "gene_names_uniprotkb": "Sfxn1", "gene_names_refseq": "2810002O05Rik; A930015P12Rik; Sfxn1", "protein_names_uniprotkb": "Sideroflexin-1", "protein_names_refseq": "flexed tail; sideroflexin-1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:14057)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11274051;29187734;33300544;34428180;37453647", "class_list": "", "function": "Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UB44;Q9CZG4", "ec_number_list": "", "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015194 L-serine transmembrane transporter activity;GO:0015075 monoatomic ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015825 L-serine transport;GO:0030218 erythrocyte differentiation;GO:0006730 one-carbon metabolic process;GO:0006826 iron ion transport;GO:0015808 L-alanine transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99JR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JR8-1", "uniprot_id": "SMRD2_MOUSE", "mass": 59085.0, "length": 531, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2", "gene_name": "Smarcd2", "organism": "Mouse", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 isoform 1", "refseq_ac": "NP_001123659", "gene_names_uniprotkb": "Smarcd2; Baf60b", "gene_names_refseq": "Baf60b; Smarcd2", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2; 60 kDa BRG-1/Brm-associated factor subunit B; BAF60B; BRG1-associated factor 60B", "protein_names_refseq": "60 kDa BRG-1/Brm-associated factor subunit B; BRG1-associated factor 60B; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 isoform 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); Coffin-Siris syndrome (Disease Ontology:DOID:1925)", "pathway": " (mmu:83796); (R-MMU-3214858); (R-MMU-8939243); (R-MMU-9933939); (R-MMU-9933946); (R-MMU-9933947); (R-MMU-9934037)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "21183079;21750661;25428506;30084848;30779550;31219806;34428180;37507081;39627609", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1ARI7;B1ARJ6", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0016363 nuclear matrix;GO:0000776 kinetochore", "go_biological_process": "GO:2000819 regulation of nucleotide-excision repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045597 positive regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q99JR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KC7-1", "uniprot_id": "SMAGP_MOUSE", "mass": 10696.0, "length": 97, "protein_name": "Small cell adhesion glycoprotein", "gene_name": "Smagp", "organism": "Mouse", "refseq_name": "small cell adhesion glycoprotein isoform 1", "refseq_ac": "NP_001029044", "gene_names_uniprotkb": "Smagp", "gene_names_refseq": "Smagp", "protein_names_uniprotkb": "Small cell adhesion glycoprotein; Small transmembrane and glycosylated protein", "protein_names_refseq": "small cell adhesion glycoprotein isoform 1; small cell transmembrane and glycosylated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:207818)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation (By similarity)., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99KC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99P68-1", "uniprot_id": "SOST_MOUSE", "mass": 23501.0, "length": 211, "protein_name": "Sclerostin", "gene_name": "Sost", "organism": "Mouse", "refseq_name": "sclerostin precursor", "refseq_ac": "NP_077769", "gene_names_uniprotkb": "Sost", "gene_names_refseq": "5430411E23Rik; Sost", "protein_names_uniprotkb": "Sclerostin", "protein_names_refseq": "sclerostin precursor", "tax_id": 10090, "disease": "sclerosteosis (Disease Ontology:DOID:0060251); sclerosteosis 1 (Disease Ontology:DOID:0060756); SOST-related sclerosing bone dysplasia (Disease Ontology:DOID:0080036); autosomal dominant craniodiaphyseal dysplasia (Disease Ontology:DOID:0080807)", "pathway": " (mmu:74499); (R-MMU-3772470)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11179006;12702725;15199066;15778503;19166819;19419300;39074536", "class_list": "", "function": "Effects of sclerostin on the activity of BMP2, BMP4, BMP6, and BMP7 and role in bone remodeling, [RefSeq, PubMed]; Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation., [UniProtKB, PubMed]; Noggin and sclerostin form a mutually inhibitory complex that fine-tunes of BMP activity in bone homeostasis, [RefSeq, PubMed]; PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RQA5;Q9D3L7", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0030246 carbohydrate binding;GO:0036122 BMP binding;GO:0140297 DNA-binding transcription factor binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0009612 response to mechanical stimulus;GO:0045893 positive regulation of DNA-templated transcription;GO:0030514 negative regulation of BMP signaling pathway;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99P68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQQ0-1", "uniprot_id": "SMIM8_MOUSE", "mass": 11064.0, "length": 97, "protein_name": "Small integral membrane protein 8", "gene_name": "Smim8", "organism": "Mouse", "refseq_name": "small integral membrane protein 8", "refseq_ac": "NP_001317684", "gene_names_uniprotkb": "Smim8", "gene_names_refseq": "1810030N24Rik; 2810406B13Rik; Smim8", "protein_names_uniprotkb": "Small integral membrane protein 8", "protein_names_refseq": "UPF0708 protein C6orf162 homolog; small integral membrane protein 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:66291)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CY70", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CQQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXH7-1", "uniprot_id": "SGO1_MOUSE", "mass": 58966.0, "length": 517, "protein_name": "Shugoshin 1", "gene_name": "Sgo1", "organism": "Mouse", "refseq_name": "shugoshin 1", "refseq_ac": "NP_082508", "gene_names_uniprotkb": "Sgo1; Sgol1", "gene_names_refseq": "3300001M08Rik; Sgo1; Sgol1", "protein_names_uniprotkb": "Shugoshin 1; Shugoshin-like 1", "protein_names_refseq": "shugoshin 1A protein; shugoshin 1; shugoshin-like 1", "tax_id": 10090, "disease": "chronic atrial and intestinal dysrhythmia (Disease Ontology:DOID:0060339)", "pathway": " (mmu:72415); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-69273); (R-MMU-9648025)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "15737064;18084284;18331714;18949044;31019073;32857910;34428180", "class_list": "", "function": "GSK3-ARC/Arg3.1 and GSK3-Wnt signaling axes trigger amyloid-beta accumulation and neuroinflammation in middle-aged Shugoshin 1 mice., [RefSeq, PubMed]; Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Involved in centromeric enrichment of AUKRB in prometaphase., [UniProtKB, PubMed, UniProtKB, PubMed]; Prevention of premature separation of sister chromatids in meiosis I requires the retention of centromeric Sgo1, while normal separation of sister chromatids in meiosis II requires loss of centromeric Sgo1., [RefSeq, PubMed]; The results show that shugoshin protects the centromeric synaptonemal complex in meiotic prophase and, in anaphase, promotes the proper segregation of partner chromosomes that are not linked by a crossover., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4K4;Q588H1;Q8BKW2", "ec_number_list": "", "go_molecular_function": "GO:0019900 kinase binding", "go_cellular_component": "GO:0030892 mitotic cohesin complex;GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0071962 mitotic sister chromatid cohesion, centromeric", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CXH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D489-1", "uniprot_id": "SOLH2_MOUSE", "mass": 51325.0, "length": 467, "protein_name": "Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2", "gene_name": "Sohlh2", "organism": "Mouse", "refseq_name": "spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2", "refseq_ac": "NP_083213", "gene_names_uniprotkb": "Sohlh2; Tohlh2", "gene_names_refseq": "4933406N12Rik; Sohlh2; Sosf2", "protein_names_uniprotkb": "Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2", "protein_names_refseq": "spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:74434)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16564520;16765102;18339773;18753606;22056784;28504655;37875506", "class_list": "", "function": "Knockout of this protein causes degegneration of spermatogonia in mice., [RefSeq, PubMed]; Sohlh2 is a critical factor for maintenance and differentiation of the oocyte during early oogenesis, [RefSeq, PubMed]; Sohlh2 promotes pulmonary fibrosis via repression of p62/Keap1/Nrf2 mediated anti-oxidative signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The expression pattern of SOHLH2 suggests that it may be a critical regulator of early germ cell development., [RefSeq, PubMed]; Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation (PubMed:22056784). Coordinates oocyte differentiation without affecting meiosis I (PubMed:28504655)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4JI40", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009994 oocyte differentiation;GO:0001545 primary ovarian follicle growth;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D489-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JIS3-1", "uniprot_id": "SMCO4_MOUSE", "mass": 6694.0, "length": 59, "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 4", "gene_name": "Smco4", "organism": "Mouse", "refseq_name": "single-pass membrane and coiled-coil domain-containing protein 4", "refseq_ac": "NP_573477", "gene_names_uniprotkb": "Smco4; Fn5", "gene_names_refseq": "Fn5; Smco4", "protein_names_uniprotkb": "Single-pass membrane and coiled-coil domain-containing protein 4; Protein FN5", "protein_names_refseq": "UPF0443 protein C11orf75 homolog; single-pass membrane and coiled-coil domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:170748)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10863097;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VD32", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JIS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QY31-1", "uniprot_id": "SNAI3_MOUSE", "mass": 31636.0, "length": 287, "protein_name": "Zinc finger protein SNAI3", "gene_name": "Snai3", "organism": "Mouse", "refseq_name": "zinc finger protein SNAI3", "refseq_ac": "NP_038942", "gene_names_uniprotkb": "Snai3; Smuc; Zfp293", "gene_names_refseq": "Smuc; Snai3; Zfp293", "protein_names_uniprotkb": "Zinc finger protein SNAI3; Protein snail homolog 3; Snail-related gene from muscle cells; Zinc finger protein 293", "protein_names_refseq": "protein snail homolog 3; snail-related gene from muscle cells; snail-related protein 2; zinc finger protein 293; zinc finger protein SNAI3", "tax_id": 10090, "disease": "central nervous system cancer (Disease Ontology:DOID:3620)", "pathway": " (mmu:30927)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10606664;14655014;15870897;16568079;26753613;26831822;29445069", "class_list": "", "function": "Data suggest that expression of SNAI3 in ovary is reduced during ovulation, after which it increases gradually during luteinization. During early embryo cleavage, SNAI3 is localized to nucleus, except nucleolus at germinal vesicle and one-cell stages., [RefSeq, PubMed]; Expression of Snai3 was studied during mouse development., [RefSeq, PubMed]; Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3'., [UniProtKB, PubMed]; Snail genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication, [RefSeq, PubMed]; Snail is present in activated mesenchymal cells indicating its relevance in the communication between tumor and stroma and suggest that it can promote the conversion of carcinoma cells to stromal cells., [RefSeq, PubMed]; The data presented here demonstrate that Snai2 and Snai3 transcriptionally regulate the cellular fitness and functionality of not only CD4(+) regulatory T cells but effector CD8(alpha+) and CD4(+) conventional T cells as well., [RefSeq, PubMed]; Using global gene expression analysis of partially reprogrammed cells, we identified SNAI3 as a novel invasion-related marker in human melanoma. SNAI3 expression correlates with tumor thickness in primary melanomas and thus, may be of prognostic value, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3U2;Q496S5;Q8C244", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QY31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYJ1-1", "uniprot_id": "SIA7E_MOUSE", "mass": 38430.0, "length": 336, "protein_name": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5", "gene_name": "St6galnac5", "organism": "Mouse", "refseq_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5", "refseq_ac": "NP_036158", "gene_names_uniprotkb": "St6galnac5; Siat7e", "gene_names_refseq": "Siat7e; St6galnac5", "protein_names_uniprotkb": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; 2.4.99.-; GD1 alpha synthase; GalNAc alpha-2,6-sialyltransferase V; SIAT7-E; ST6GalNAc V; ST6GalNAcV; Sialyltransferase 7E", "protein_names_refseq": "GD1 alpha synthase; SIAT7-E; ST6GalNAc V; ST6GalNAcV; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; galNAc alpha-2,6-sialyltransferase V; sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) E; sialyltransferase 7E", "tax_id": 10090, "disease": "", "pathway": " (mmu:26938); (R-MMU-4085001); (R-MMU-9840309)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10521438;10601645;9157980", "class_list": "glycogene;glycosyltransferase", "function": "Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:10521438, PubMed:10601645). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (PubMed:9157980). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0K6", "ec_number_list": "2.4.3.3;2.4.99.-;2.4.3.7", "go_molecular_function": "GO:0008373 sialyltransferase activity;GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0009101 glycoprotein biosynthetic process;GO:0009311 oligosaccharide metabolic process;GO:0009312 oligosaccharide biosynthetic process;GO:0001574 ganglioside biosynthetic process", "synthesized_glycan_count": 550, "hit_score": 0.7, "record_id": "Q9QYJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZ28-1", "uniprot_id": "SIX6_MOUSE", "mass": 27741.0, "length": 246, "protein_name": "Homeobox protein SIX6", "gene_name": "Six6", "organism": "Mouse", "refseq_name": "homeobox protein SIX6", "refseq_ac": "NP_035514", "gene_names_uniprotkb": "Six6; Optx2; Six9", "gene_names_refseq": "Optx2; Six6; Six9", "protein_names_uniprotkb": "Homeobox protein SIX6; Optic homeobox 2; Sine oculis homeobox homolog 6; Six9 protein", "protein_names_refseq": "homeobox protein SIX6; optic homeobox 2; sine oculis homeobox homolog 6; sine oculis-related homeobox 6 homolog", "tax_id": 10090, "disease": "optic disc anomalies with retinal and/or macular dystrophy (Disease Ontology:DOID:0080635)", "pathway": " (mmu:20476)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10381575;10473118;12050133;9724757", "class_list": "", "function": "May be involved in eye development., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 12 and is thought to be involved in eye development. The encoded transcription factor regulates early progenitor cell proliferation during mammalian retinogenesis and pituitary development. Mice lacking this gene exhibit abnormal development of the suprachiasmatic nucleus and circadian rhythms. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88423", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QZ28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QZ39-1", "uniprot_id": "SIA7A_MOUSE", "mass": 60734.0, "length": 526, "protein_name": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1", "gene_name": "St6galnac1", "organism": "Mouse", "refseq_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1", "refseq_ac": "NP_035501", "gene_names_uniprotkb": "St6galnac1; Siat7a", "gene_names_refseq": "Siat7a; St6galnac1", "protein_names_uniprotkb": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; 2.4.3.3; GalNAc alpha-2,6-sialyltransferase I; SIAT7-A; ST6GalNAc I; ST6GalNAcI; Sialyltransferase 7A", "protein_names_refseq": "SIAT7-A; ST6GalNAc I; ST6GalNAcI; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) A; sialyltransferase 7A", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)", "pathway": " (mmu:20445); (R-MMU-4085001)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10788794;15383613;16207894;22228572;27235117;33300544;35303419", "class_list": "glycogene;glycosyltransferase", "function": "It was confirmed that MUC1 carries sialyl Tn also in human advanced gastric cancer tissues, [RefSeq, PubMed]; Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis (PubMed:35303419). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins (PubMed:10788794). Catalyzes the formation of the sialyl-Tn (S-Tn) antigen, an antigen found in intestinal goblet cells (PubMed:35303419, PubMed:16207894). Protein sialylation in globlet cells is essential for mucus integrity and is required to protect the intestinal mucus against excessive bacterial proteolytic degradation (PubMed:35303419)., [UniProtKB, PubMed, PubMed]; Results suggest a role of ST6GalNAc I in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT/NF-kappa B signaling, and ST6GalNAc I might be a marker for the prognosis and therapy of hepatocarcinoma. Erratum:[Tumour Biol. 2021;43(1):75-76. doi: 10.3233/TUB-219003. PMID: 33935134], [RefSeq, PubMed]; ST6GalNAc I has a role in O-glycosylation of the integrin beta1 chain and integrin beta 1-mediated signalling, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 83, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AA23;Q9JJP5", "ec_number_list": "2.4.3.3;2.4.99.-;2.4.3.7", "go_molecular_function": "GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0009312 oligosaccharide biosynthetic process;GO:0001574 ganglioside biosynthetic process;GO:0048874 host-mediated modulation of intestinal microbiota composition;GO:0051851 host-mediated perturbation of symbiont process", "synthesized_glycan_count": 550, "hit_score": 1.0, "record_id": "Q9QZ39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R097-1", "uniprot_id": "SPIT1_MOUSE", "mass": 56591.0, "length": 507, "protein_name": "Kunitz-type protease inhibitor 1", "gene_name": "Spint1", "organism": "Mouse", "refseq_name": "kunitz-type protease inhibitor 1 precursor", "refseq_ac": "NP_058603", "gene_names_uniprotkb": "Spint1; Hai1", "gene_names_refseq": "HAI-1; Spint1", "protein_names_uniprotkb": "Kunitz-type protease inhibitor 1; HAI-1; Hepatocyte growth factor activator inhibitor type 1", "protein_names_refseq": "Kunitz-type protease inhibitor 1; hepatocyte growth factor activator inhibitor type 1; kunitz-type protease inhibitor 1 precursor", "tax_id": 10090, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); Alzheimer's disease (Disease Ontology:DOID:10652); biliary atresia (Disease Ontology:DOID:13608); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); liver cirrhosis (Disease Ontology:DOID:5082); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (mmu:20732); (R-MMU-6806942); (R-MMU-8852405)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11406276;15964823;18250455;19349973;27802388;30084848;31997435", "class_list": "", "function": "Ese results suggest that serine proteases promote intestinal carcinogenesis through activation of PAR-2, and that HAI-1 plays a critical tumor suppressor role as an inhibitor of matriptase, kallikreins, and other PAR-2 activating proteases., [RefSeq, PubMed]; HAI-1 is required for branching morphogenesis in the chorioallantoic placenta., [RefSeq, PubMed]; Inhibitor of HGFAC (By similarity). Inhibits serine protease activity of ST14/matriptase in vitro (By similarity). Inhibits serine protease activity of TMPRSS13, via the BPTI/Kunitz inhibitor 1 domain (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q99J04", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060429 epithelium development;GO:0045687 positive regulation of glial cell differentiation;GO:0030198 extracellular matrix organization;GO:0008544 epidermis development;GO:0001843 neural tube closure", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9R097-1", "record_type": "protein" }, { "uniprot_canonical_ac": "V9GXG1-1", "uniprot_id": "SLN14_MOUSE", "mass": 101690.0, "length": 899, "protein_name": "Protein SLFN14", "gene_name": "Slfn14", "organism": "Mouse", "refseq_name": "protein SLFN14", "refseq_ac": "NP_001159500", "gene_names_uniprotkb": "Slfn14", "gene_names_refseq": "Gm20; Slfn14-ps; Slfn14", "protein_names_uniprotkb": "Protein SLFN14; Schlafen family member 14", "protein_names_refseq": "Schlafen family member 14, CAST_EiJ strain specific; Schlafen family member 14, WSB_EiJ strain specific; protein SLFN14; schlafen family member 14, pseudogene", "tax_id": 10090, "disease": "platelet-type bleeding disorder 20 (Disease Ontology:DOID:0111055)", "pathway": " (mmu:237890)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19619625;25996083;28734654;33496736", "class_list": "", "function": "Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner. Involved in correct maturation of megakaryocytes and especially important for proplatelet extension (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Heterozygous mutation SLFN14 K208N in mice mediates species-specific differences in platelet and erythroid lineage commitment., [RefSeq, PubMed]; SLFN14 is a novel antiviral factor for both DNA and RNA viruses, [RefSeq, PubMed]; Shows no ribosome-associated and endoribonuclease activities., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0043022 ribosome binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006402 mRNA catabolic process;GO:0071286 cellular response to magnesium ion;GO:0071287 cellular response to manganese ion;GO:0016075 rRNA catabolic process;GO:0036345 platelet maturation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "V9GXG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70559-1", "uniprot_id": "SPR2H_MOUSE", "mass": 11720.0, "length": 108, "protein_name": "Small proline-rich protein 2H", "gene_name": "Sprr2h", "organism": "Mouse", "refseq_name": "small proline-rich protein 2H", "refseq_ac": "NP_035604", "gene_names_uniprotkb": "Sprr2h", "gene_names_refseq": "Sprr2h", "protein_names_uniprotkb": "Small proline-rich protein 2H", "protein_names_refseq": "small proline-rich protein 2H", "tax_id": 10090, "disease": "", "pathway": " (mmu:20762)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12584609;15232223;21750661;9888996", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70559-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A7DTG3-1", "uniprot_id": "SRTD4_MOUSE", "mass": 41096.0, "length": 377, "protein_name": "SERTA domain-containing protein 4", "gene_name": "Sertad4", "organism": "Mouse", "refseq_name": "SERTA domain-containing protein 4", "refseq_ac": "NP_001171265", "gene_names_uniprotkb": "Sertad4", "gene_names_refseq": "4833404A09; C130018M11Rik; Sertad4", "protein_names_uniprotkb": "SERTA domain-containing protein 4", "protein_names_refseq": "SERTA domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:214791)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16546331;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PAK2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A7DTG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3Z752-1", "uniprot_id": "SPXN_MOUSE", "mass": 13004.0, "length": 116, "protein_name": "Spexin", "gene_name": "Spx", "organism": "Mouse", "refseq_name": "spexin isoform 2 precursor", "refseq_ac": "NP_001355944", "gene_names_uniprotkb": "Spx", "gene_names_refseq": "B230216G23Rik; Npq; Spx", "protein_names_uniprotkb": "Spexin; NPQ; Neuropeptide Q; Spexin hormone", "protein_names_refseq": "neuropeptide Q; spexin isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:319552)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;22038051;24550067;32093887;34025589;38726666", "class_list": "", "function": "Acts as a ligand for galanin receptors GALR2 and GALR3. Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles (By similarity). Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (PubMed:24550067)., [UniProtKB, PubMed]; Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity)., [UniProtKB]; Mouse Spexin: (III) Differential Regulation by Glucose and Insulin in Glandular Stomach and Functional Implication in Feeding Control. Publication Status: Online-Only, [RefSeq, PubMed]; Newly identified peptides derived from the NPQ/spexin precursor contribute to CNS-mediated control of arterial blood pressure and salt and water balance and modulate nociceptive responses, [RefSeq, PubMed]; Plays a role as a central modulator of cardiovascular and renal function and nociception. Also plays a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity)., [UniProtKB]; Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2., [RefSeq, PubMed]; Spexin as an anxiety regulator in mouse hippocampus: Mechanisms for transcriptional regulation of spexin gene expression by corticotropin releasing factor., [RefSeq, PubMed]; Spexin is a novel hormone involved in weight regulation, with potential for obesity therapy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031765 type 2 galanin receptor binding;GO:0031766 type 3 galanin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030133 transport vesicle;GO:0031045 dense core granule", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0003084 positive regulation of systemic arterial blood pressure;GO:0035814 negative regulation of renal sodium excretion;GO:0051930 regulation of sensory perception of pain;GO:0044539 long-chain fatty acid import into cell", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D3Z752-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4U0-1", "uniprot_id": "STAB2_MOUSE", "mass": 277532.0, "length": 2559, "protein_name": "Stabilin-2", "gene_name": "Stab2", "organism": "Mouse", "refseq_name": "stabilin-2 precursor", "refseq_ac": "NP_619614", "gene_names_uniprotkb": "Stab2; Feel2; Hare", "gene_names_refseq": "FEEL-2; FELL; MFEEL-2; STAB-2; Stab2", "protein_names_uniprotkb": "Stabilin-2; FEEL-2; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2", "protein_names_refseq": "fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2; scavenger receptor FEEL-2; stabilin-2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:192188); (R-MMU-2142845); (R-MMU-2160916); (R-MMU-3000497)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "11829752;12473645;14598175;15572036;15907457;17242355;18230608;21183079;21750661;25428506;26740625;29187734;30084848;30779550;31616917;34428180;37357460;38946049;40885482;40997131", "class_list": "", "function": "Analysis of mouse fasciclin-containing genes (betaigH3, periostin, stabilin-1, and stabilin-2) expression patterns during valvuloseptal morphogenesis, [RefSeq, PubMed]; Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice., [RefSeq, PubMed]; FEEL-1 and this protein are endocytic receptors for advanced glycation end products., [RefSeq, PubMed]; MStab-2 might be involved in the clearance of hyaluronan from the lymph or the blood circulation via the network of endothelial sinuses, [RefSeq, PubMed]; Phenotypical and biochemical characterization of murine psoriasiform and fibrotic skin disease models in Stabilin-deficient mice., [RefSeq, PubMed]; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Also acts, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed short form also functions as an endocytosis receptor for heparin internalization as well as HA and CS., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 29, "predicted_n_glycosites": 29, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 10, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 32, "binding_glycan_count": 0, "secondary_ac_list": "Q8BM87", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005509 calcium ion binding;GO:0005041 low-density lipoprotein particle receptor activity;GO:0030169 low-density lipoprotein particle binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007155 cell adhesion;GO:0050830 defense response to Gram-positive bacterium;GO:0006898 receptor-mediated endocytosis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8R4U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9QAF0-1", "uniprot_id": "SPT31_MOUSE", "mass": 115834.0, "length": 1014, "protein_name": "Spermatogenesis-associated protein 31", "gene_name": "Spata31", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 31", "refseq_ac": "NP_084323", "gene_names_uniprotkb": "Spata31; Aep1; Vad1.3", "gene_names_refseq": "4930458L03Rik; Aep1; Fam75a; Spata31a; Spata31; Vad1.3", "protein_names_uniprotkb": "Spermatogenesis-associated protein 31; Acrosome-expressed protein 1", "protein_names_refseq": "acrosome expressed protein 1; acrosome-specific protein VAD1.3; family with sequence similarity 75, member A; spermatogenesis-associated protein 31", "tax_id": 10090, "disease": "", "pathway": " (mmu:78124)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16924657;20850414;21750661;25930072;35820727", "class_list": "", "function": "May play a role in spermatogenesis., [UniProtKB]; Targeted disruption of the spermatid-specific gene Spata31 causes male infertility., [RefSeq, PubMed]; VAD1.3 interacts with beta-actin and syntaxin 1 in vitro., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5MAT5", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane;GO:0043160 acrosomal lumen", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E9QAF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A6C4-1", "uniprot_id": "SPP2C_MOUSE", "mass": 76266.0, "length": 690, "protein_name": "Signal peptide peptidase-like 2C", "gene_name": "Sppl2c", "organism": "Mouse", "refseq_name": "signal peptide peptidase-like 2C isoform b precursor", "refseq_ac": "NP_001076004", "gene_names_uniprotkb": "Sppl2c; Imp5", "gene_names_refseq": "4933407P14Rik; IMP5; Sppl2c", "protein_names_uniprotkb": "Signal peptide peptidase-like 2C; 3.4.23.-; IMP-5; Intramembrane protease 5; SPP-like 2C; SPPL2c", "protein_names_refseq": "IMP-5; ortholog of human intramembrane protease 5 IMP5; protein SPP-like 2C; protein SPPL2c; signal peptide peptidase-like 2C isoform b precursor; signal peptide peptidase-like 2C", "tax_id": 10090, "disease": "", "pathway": " (mmu:237958)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "30733280;30733281;31219806;35960805", "class_list": "", "function": "In round spermatids, acts as a scaffold protein supporting FREY1 in IZUMO1 recruitment at the endoplasmic reticulum membrane and coordination of IZUMO1 complex assembly. Stabilizes FREY1 at the endoplasmic reticulum membrane through interaction. May recruit IZUMO1 interaction partners., [UniProtKB, PubMed]; No difference in cleavage specificity compared to isoform 1., [UniProtKB, PubMed]; Sperm-specific intramembrane-cleaving aspartic protease (I-CLiP) that cleaves distinct tail-anchored proteins and SNARE proteins (PubMed:30733280, PubMed:30733281, PubMed:35960805). In elongated spermatids, modulates intracellular Ca(2+) homeostasis by controlling PLN abundance through proteolytic cleavage (PubMed:30733280). During spermatogenesis, processes SNARE proteins and impacts vesicular trafficking which supports compartmental reorganization in maturating spermatids and may play a role in formation of the acrosome (PubMed:30733281)., [UniProtKB, PubMed, PubMed, PubMed]; The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA2)-regulating protein phospholamban (PLN) is identified as a physiological SPPL2c substrate., [RefSeq, PubMed]; These data suggest involvement of SPPL2c in acrosome formation during spermatogenesis. Erratum:[EMBO Rep. 2019 May;20(5):e48133. doi: 10.15252/embr.201948133. PMID: 31061204], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q497R4;Q8BHP0", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042803 protein homodimerization activity;GO:0004190 aspartic-type endopeptidase activity;GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030660 Golgi-associated vesicle membrane;GO:0098553 lumenal side of endoplasmic reticulum membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0006874 intracellular calcium ion homeostasis;GO:0050821 protein stabilization;GO:0031293 membrane protein intracellular domain proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2A6C4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D975-1", "uniprot_id": "SRXN1_MOUSE", "mass": 14149.0, "length": 136, "protein_name": "Sulfiredoxin-1", "gene_name": "Srxn1", "organism": "Mouse", "refseq_name": "sulfiredoxin-1", "refseq_ac": "NP_083964", "gene_names_uniprotkb": "Srxn1; Npn3; Srx", "gene_names_refseq": "1700127B04Rik; Npn3; Srx1; Srxn1; Srx; TX01", "protein_names_uniprotkb": "Sulfiredoxin-1; 1.8.98.2; Neoplastic progression protein 3", "protein_names_refseq": "neoplastic progression 3; neoplastic progression protein 3; sulfiredoxin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76650); (R-MMU-9818027)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15448164;21750661;31284950;31504396;38354630;39191723", "class_list": "", "function": "Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase., [UniProtKB, PubMed, UniProtKB, UniProtKB]; DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis., [RefSeq, PubMed]; Essential for normal responses to GnRH stimulation and plays an important role in reactive oxygen species management, [RefSeq, PubMed]; TRPA1 aggravates osteoclastogenesis and osteoporosis through activating endoplasmic reticulum stress mediated by SRXN1. Publication Status: Online-Only, [RefSeq, PubMed]; These results demonstrated that Srxn1 protects podocytes from high glucose-induced injury by promoting the activation of Nrf2/ARE signaling associated with inactivating GSK-3beta, indicating a potential role of Srxn1 in diabetic nephropathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWN6;Q91VN5", "ec_number_list": "1.11.1.24;1.8.98.2", "go_molecular_function": "GO:0016667 oxidoreductase activity, acting on a sulfur group of donors;GO:0005524 ATP binding;GO:0032542 sulfiredoxin activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D975-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AVA0-1", "uniprot_id": "SVEP1_MOUSE", "mass": 387457.0, "length": 3567, "protein_name": "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1", "gene_name": "Svep1", "organism": "Mouse", "refseq_name": "sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor", "refseq_ac": "NP_073725", "gene_names_uniprotkb": "Svep1", "gene_names_refseq": "1110021D17Rik; 4833413O10Rik; D430029O09Rik; Polydom; Svep1", "protein_names_uniprotkb": "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; Polydom", "protein_names_refseq": "polydomain protein (Polydom); sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor; sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:64817)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11062057;16206243;21963386;22654117;25428506;27892606;28179430;28179432;30084848;34428180;35802072;36792666;37338522;40885482", "class_list": "", "function": "Our results show that the putative promoter of SVEP1 is hypermethylated in DA3- compared with MBA-15 cells, thus regulating SVEP1 expression levels, [RefSeq, PubMed]; Polydom is a hitherto unknown ligand for integrin alpha9beta1 that functions as a physiological ligand in vivo., [RefSeq, PubMed]; Polydom/SVEP1 binds to Tie1 and promotes migration of lymphatic endothelial cells., [RefSeq, PubMed]; Required for morphological development, cell alignment and migration of lymphatic endothelial cells during embryonic development, potentially via modulation of ANGPT2-TIE1 signaling and subsequent activation of FOXC2 transcription (PubMed:28179430). Required for embryonic lymphatic vascular development, via mediating the correct formation of the first lymphovenous contact site and tight association of the lymphatic endothelium with the venous endothelium (PubMed:28179432). Represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells, via its interaction with integrins, thereby inhibiting vasocontraction (PubMed:35802072). Promotes platelet activation, via its interaction with PEAR1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). Plays a role in epidermal development and keratinocyte differentiation, independent of cell-cell adhesion (PubMed:27892606). May play a role in initial cell attachment of stromal osteogenic cells (PubMed:16206243). May promote myoblast cell adhesion when in the presence of integrin ITGA9:ITGB1 (PubMed:22654117)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SVEP1 is an endogenous ligand for the orphan receptor PEAR1. Erratum:[Nat Commun. 2023 Mar 17;14(1):1511. doi: 10.1038/s41467-023-37005-x. PMID: 36932061] Publication Status: Online-Only, [RefSeq, PubMed]; The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins alpha9beta1 and alpha4beta1., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q8C720;Q8CBT2;Q922H0;Q9CUT3;Q9ES77", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005178 integrin binding;GO:0005509 calcium ion binding;GO:0098640 integrin binding involved in cell-matrix adhesion", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0036303 lymph vessel morphogenesis;GO:0016477 cell migration;GO:0008544 epidermis development;GO:0045906 negative regulation of vasoconstriction;GO:0048014 Tie signaling pathway", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "A2AVA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2RRY8-1", "uniprot_id": "SPAS1_MOUSE", "mass": 30169.0, "length": 269, "protein_name": "Spermatogenesis-associated serine-rich protein 1", "gene_name": "Spats1", "organism": "Mouse", "refseq_name": "spermatogenesis-associated serine-rich protein 1 isoform 1", "refseq_ac": "NP_081925", "gene_names_uniprotkb": "Spats1; Ddip", "gene_names_refseq": "1700011H05Rik; 4933400B06Rik; Ddip; Spats1; Srsp1", "protein_names_uniprotkb": "Spermatogenesis-associated serine-rich protein 1; Dvl2-DEP domain-interacting protein", "protein_names_refseq": "dvl2-DEP domain-interacting protein; spermatogenesis-associated serine-rich protein 1 isoform 1; spermatogenesis-associated serine-rich protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71020)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;40885482", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6VNB9;Q9CUD9;Q9DAG2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2RRY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C8K3-1", "uniprot_id": "SRS12_MOUSE", "mass": 29664.0, "length": 266, "protein_name": "Serine/arginine-rich splicing factor 12", "gene_name": "Srsf12", "organism": "Mouse", "refseq_name": "serine/arginine-rich splicing factor 12 isoform 2", "refseq_ac": "NP_808442", "gene_names_uniprotkb": "Srsf12; Sfrs13b; Srrp; Srsf13b", "gene_names_refseq": "B830039L16; Sfrs13b; Srrp; Srsf12; Srsf13b", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 12; Splicing factor, arginine/serine-rich 13B", "protein_names_refseq": "serine-arginine repressor protein; serine/arginine-rich splicing factor 12 isoform 2; serine/arginine-rich splicing factor 12; serine/arginine-rich splicing factor 13B; splicing factor, arginine/serine-rich 13B", "tax_id": 10090, "disease": "", "pathway": " (mmu:272009)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C8K3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPQ7-1", "uniprot_id": "STAR5_MOUSE", "mass": 23922.0, "length": 213, "protein_name": "StAR-related lipid transfer protein 5", "gene_name": "Stard5", "organism": "Mouse", "refseq_name": "stAR-related lipid transfer protein 5", "refseq_ac": "NP_075866", "gene_names_uniprotkb": "Stard5", "gene_names_refseq": "2310058G22Rik; D7Ertd152e; Stard5", "protein_names_uniprotkb": "StAR-related lipid transfer protein 5; START domain-containing protein 5; StARD5", "protein_names_refseq": "18B7-T7(GS); START domain-containing protein 5; StAR-related lipid transfer (START) domain containing 5; StAR-related protein 1-4E; StAR-related protein p3-15E/p3-16E; stAR-related lipid transfer protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:170460); (R-MMU-159418)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11247670;12011452;15760897;21750661;31015253;38591148", "class_list": "", "function": "May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols., [UniProtKB, UniProtKB, UniProtKB]; StarD4 is regulated by sterols via SREBP-2, and StarD5 is activated by ER stress cholesterol metabolism; they serve different functions, [RefSeq, PubMed]; StarD5 levels of expression correlate with onset and progression of steatosis and liver fibrosis., [RefSeq, PubMed]; The studies show that StarD5 is a stress-responsive protein that regulates PM cholesterol and intracellular cholesterol homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQY0;Q9EPQ6", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0032052 bile acid binding;GO:0120020 cholesterol transfer activity;GO:0008289 lipid binding", "go_cellular_component": "", "go_biological_process": "GO:0070508 cholesterol import;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EPQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YD6-1", "uniprot_id": "SRGEF_MOUSE", "mass": 49226.0, "length": 464, "protein_name": "Secretion-regulating guanine nucleotide exchange factor", "gene_name": "Sergef", "organism": "Mouse", "refseq_name": "secretion-regulating guanine nucleotide exchange factor", "refseq_ac": "NP_038817", "gene_names_uniprotkb": "Sergef; Delgef; Gnefr", "gene_names_refseq": "DelGEF; Gef; Gnefr; Gnef; Sergef", "protein_names_uniprotkb": "Secretion-regulating guanine nucleotide exchange factor; Deafness locus-associated putative guanine nucleotide exchange factor; DelGEF; Guanine nucleotide exchange factor-related protein", "protein_names_refseq": "deafness locus-associated putative guanine nucleotide exchange factor; guanine nucleotide exchange factor (RCC1 related); guanine nucleotide exchange factor-related protein; secretion-regulating guanine nucleotide exchange factor", "tax_id": 10090, "disease": "atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (mmu:27414)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10571079;21750661;27163697", "class_list": "", "function": "Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process., [UniProtKB, UniProtKB, UniProtKB]; Rac1 activation is caused by membrane translocation of a guanine nucleotide exchange factor FLJ00068 in Akt2-mediated insulin signaling in mouse skeletal muscle. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VDT0;Q3UGM8;Q3UKY0;Q9QXB7", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050709 negative regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80YD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56873-1", "uniprot_id": "ZNRD2_MOUSE", "mass": 21336.0, "length": 199, "protein_name": "Protein ZNRD2", "gene_name": "Znrd2", "organism": "Mouse", "refseq_name": "protein ZNRD2", "refseq_ac": "NP_065237", "gene_names_uniprotkb": "Znrd2; C184l; Sssca1", "gene_names_refseq": "1500016H19Rik; C184L; Sssca1; Znrd2", "protein_names_uniprotkb": "Protein ZNRD2; Autoantigen p27 homolog; Protein C184L; Protein zinc ribbon domain type 2; Sjoegren syndrome/scleroderma autoantigen 1 homolog; Zinc ribbon domain-containing protein 2", "protein_names_refseq": "Sjogren syndrome/scleroderma autoantigen 1; Sjogren's syndrome/scleroderma autoantigen 1 homolog; autoantigen p27 homolog; protein ZNRD2; protein zinc ribbon domain type 2; sjoegren syndrome/scleroderma autoantigen 1 homolog; zinc ribbon domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56390)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10512749;21750661;28135057", "class_list": "", "function": "Might play a role in mitosis. Could be a centromere-associated protein. Antigenic molecule. May induce anti-centromere antibodies., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P56873-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQQ0-1", "uniprot_id": "SUV92_MOUSE", "mass": 54098.0, "length": 477, "protein_name": "Histone-lysine N-methyltransferase SUV39H2", "gene_name": "Suv39h2", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase SUV39H2", "refseq_ac": "NP_073561", "gene_names_uniprotkb": "Suv39h2", "gene_names_refseq": "4930507K23Rik; D030054H19Rik; D2Ertd544e; KMT1B; Suv39h2", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SUV39H2; 2.1.1.-; H3-K9-HMTase 2; Histone H3-K9 methyltransferase 2; Su(var)3-9 homolog 2; Suppressor of variegation 3-9 homolog 2", "protein_names_refseq": "H3-K9-HMTase 2; Suv39h histone methyltransferase; histone H3-K9 methyltransferase 2; histone-lysine N-methyltransferase SUV39H2; su(var)3-9 homolog 2; suppressor of variegation 3-9 homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:64707); (R-MMU-3214841)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11094092;11701123;12398767;14690609;14690610;14702045;21183079;21750661;22939622;24413057;30111536;32305044;34262135;38719473;38961301", "class_list": "", "function": "A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin beta-cluster genes in the developing brain., [RefSeq, PubMed]; ESET histone methyltransferase can form a large, multi-protein complex(es) with mSin3A/B co-repressors and HDAC1/2 that participates in multiple pathways of transcriptional repression., [RefSeq, PubMed]; Extreme disruption of heterochromatin is required for accelerated hematopoietic aging., [RefSeq, PubMed]; Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate (PubMed:11094092, PubMed:11701123, PubMed:14690609, PubMed:14690610, PubMed:14702045, PubMed:22939622). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones (By similarity). Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions (PubMed:14702045). H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats (By similarity). SUV39H2 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length (By similarity). May participate in regulation of higher-order chromatin organization during spermatogenesis (PubMed:11094092). Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (PubMed:24413057)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Suv39h-catalyzed H3K9me3 is critical for euchromatic genome organization and the maintenance of gene transcription. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNK2;Q9CUK3;Q9JLP7", "ec_number_list": "2.1.1.-;2.1.1.366;2.1.1.367;2.1.1.364", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0008276 protein methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0000792 heterochromatin;GO:0005721 pericentric heterochromatin;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0031508 pericentric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9EQQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBG7-1", "uniprot_id": "SRPRA_MOUSE", "mass": 69623.0, "length": 636, "protein_name": "Signal recognition particle receptor subunit alpha", "gene_name": "Srpra", "organism": "Mouse", "refseq_name": "signal recognition particle receptor subunit alpha", "refseq_ac": "NP_080406", "gene_names_uniprotkb": "Srpra; Srpr", "gene_names_refseq": "1300011P19Rik; D11Mgi27; Srpra; Srpr", "protein_names_uniprotkb": "Signal recognition particle receptor subunit alpha; DP-alpha; Docking protein alpha; SR-alpha", "protein_names_refseq": "DP-alpha; SR-alpha; docking protein alpha; signal recognition particle receptor ('docking protein'); signal recognition particle receptor subunit alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:67398)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;17242355;18250455;18630941;19144319;21183079;21750661;33725478;34428180;35820727;36210013;37828378", "class_list": "", "function": "Component of the SRP (signal recognition particle) receptor (By similarity). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (By similarity). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VC45;Q921H1", "ec_number_list": "", "go_molecular_function": "GO:0005047 signal recognition particle binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005785 signal recognition particle receptor complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045047 protein targeting to ER;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition;GO:0006614 SRP-dependent cotranslational protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9DBG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CWR7-1", "uniprot_id": "STEA1_MOUSE", "mass": 39292.0, "length": 339, "protein_name": "STEAP1 protein", "gene_name": "Steap1", "organism": "Mouse", "refseq_name": "STEAP1 protein", "refseq_ac": "NP_081675", "gene_names_uniprotkb": "Steap1; Steap", "gene_names_refseq": "2410007B19Rik; Prss24; Steap1; Steap", "protein_names_uniprotkb": "STEAP1 protein; Six-transmembrane epithelial antigen of prostate 1", "protein_names_refseq": "STEAP1 protein; metalloreductase STEAP1; six-transmembrane epithelial antigen of prostate 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70358)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "16024648;16609065;19131326;19196137;19267351;21750661;25428506;29900060;30841425;31219806;37209327;37828378", "class_list": "", "function": "Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH., [UniProtKB, PubMed]; HSP65 and STEAP1 186-193 can significantly inhibit the growth of mouse RM-1 prostate cancer., [RefSeq, PubMed]; Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells., [RefSeq, PubMed]; STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8X4", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CWR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "G3X912-1", "uniprot_id": "SPRTN_MOUSE", "mass": 55317.0, "length": 497, "protein_name": "DNA-dependent metalloprotease SPRTN", "gene_name": "Sprtn", "organism": "Mouse", "refseq_name": "DNA-dependent metalloprotease SPRTN isoform 1", "refseq_ac": "NP_001104611", "gene_names_uniprotkb": "Sprtn; Gm505", "gene_names_refseq": "Gm505; Sprtn", "protein_names_uniprotkb": "DNA-dependent metalloprotease SPRTN; 3.4.24.-; Protein with SprT-like domain at the N terminus; Spartan", "protein_names_refseq": "DNA-dependent metalloprotease SPRTN isoform 1; DNA-dependent metalloprotease SPRTN; protein with SprT-like domain at the N terminus; spartan; sprT-like domain-containing protein Spartan", "tax_id": 10090, "disease": "Ruijs-Aalfs syndrome (Disease Ontology:DOID:0111264)", "pathway": " (mmu:244666); (R-MMU-110320)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "25428506;25501849;27871365;28199696;30084848;30779550;34428180", "class_list": "", "function": "DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:27871365, PubMed:28199696). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:27871365, PubMed:28199696). Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis (By similarity). Catalyzes proteolytic cleavage of the HMCES DNA-protein cross-link following unfolding by the BRIP1/FANCJ helicase (By similarity). Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4 (By similarity). Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs. SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity). Involved in recruitment of VCP/p97 to sites of DNA damage. Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation. Does not activate CHEK1 in response to DNA damage. May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; It has been shown that the livers of Sprtn deficient mice accumulate DNA-protein crosslinks containing Topoisomerase 1 covalently linked to DNA., [RefSeq, PubMed]; The data demonstrate that Spartan plays a key role in maintaining structural and numerical chromosome integrity and suggest a link between Spartan insufficiency and progeria. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RY42", "ec_number_list": "3.4.24.-;3.6.4.6;2.7.7.7", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0003690 double-stranded DNA binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin", "go_biological_process": "GO:0006508 proteolysis;GO:0006974 DNA damage response;GO:0009411 response to UV;GO:0031398 positive regulation of protein ubiquitination;GO:0016540 protein autoprocessing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "G3X912-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13675-1", "uniprot_id": "SSTY1_MOUSE", "mass": 26796.0, "length": 232, "protein_name": "Y-linked testis-specific protein 1", "gene_name": "Ssty1", "organism": "Mouse", "refseq_name": "Y-linked testis-specific protein 1", "refseq_ac": "NP_033246", "gene_names_uniprotkb": "Ssty1; Gm21454; Smy", "gene_names_refseq": "Smy; Ssty1; Ssty", "protein_names_uniprotkb": "Y-linked testis-specific protein 1", "protein_names_refseq": "Y-linked testis-specific protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042337); (mmu:20611)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14667817;21750661;24456183;3562242;35820727", "class_list": "", "function": "SSTY proteins interact with SLY protein and its X-linked homolog SLX/SLXL1, and may be required for localization of SLX/SLY proteins in the spermatid nucleus and sex chromatin., [RefSeq, PubMed]; Ssty1 is expressed in spermatids and the protein is absent from spermatids of mice that lack Yq., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P13675-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35326-1", "uniprot_id": "SRSF5_MOUSE", "mass": 30891.0, "length": 269, "protein_name": "Serine/arginine-rich splicing factor 5", "gene_name": "Srsf5", "organism": "Mouse", "refseq_name": "serine/arginine-rich splicing factor 5 isoform 1", "refseq_ac": "NP_001073162", "gene_names_uniprotkb": "Srsf5; Hrs; Sfrs5", "gene_names_refseq": "Sfrs5; Srsf5", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 5; Delayed-early protein HRS; Pre-mRNA-splicing factor SRP40; Splicing factor, arginine/serine-rich 5", "protein_names_refseq": "delayed-early protein HRS; pre-mRNA-splicing factor SRP40; serine/arginine-rich splicing factor 5 isoform 1; serine/arginine-rich splicing factor 5; splicing factor, arginine/serine-rich 5 (SRp40, HRS)", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); colon adenocarcinoma (Disease Ontology:DOID:234); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (mmu:20384); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10823932;15684423;18758164;21750661;22872234;23806337;31219806;32152506;34203471;34428180;34887587;36064747;36210013;36257906;37453647;9434190", "class_list": "", "function": "CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of SRp40., [RefSeq, PubMed]; May be required for progression through G1 and entry into S phase of cell growth. May play a regulatory role in pre-mRNA splicing. Autoregulates its own expression. Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (By similarity)., [UniProtKB]; SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus., [RefSeq, PubMed]; The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Nov 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q640L9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0043422 protein kinase B binding;GO:0050733 RS domain binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005634 nucleus", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0009611 response to wounding;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O35326-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35704-1", "uniprot_id": "SPTC1_MOUSE", "mass": 52535.0, "length": 473, "protein_name": "Serine palmitoyltransferase 1", "gene_name": "Sptlc1", "organism": "Mouse", "refseq_name": "serine palmitoyltransferase 1 isoform 1", "refseq_ac": "NP_033295", "gene_names_uniprotkb": "Sptlc1; Lcb1", "gene_names_refseq": "E030036H05; Lcb1; SPT1; Sptlc1", "protein_names_uniprotkb": "Serine palmitoyltransferase 1; 2.3.1.50; LCB 1; Long chain base biosynthesis protein 1; SPT 1; SPT1; Serine-palmitoyl-CoA transferase 1", "protein_names_refseq": "long chain base biosynthesis protein 1; serine palmitoyltransferase 1 isoform 1; serine palmitoyltransferase 1; serine-palmitoyl-CoA transferase 1", "tax_id": 10090, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); hereditary sensory and autonomic neuropathy type 1A (Disease Ontology:DOID:0070152); hereditary sensory and autonomic neuropathy type 1 (Disease Ontology:DOID:0070162); juvenile amyotrophic lateral sclerosis type 27 (Disease Ontology:DOID:0081381)", "pathway": " (mmu:268656); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "1317856;21994399;25428506;26301690;27818258;28100772;34428180;9363775;9405408", "class_list": "glycogene", "function": "Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PubMed:28100772). The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Required for adipocyte cell viability and metabolic homeostasis (PubMed:28100772)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 29, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54813;Q8BH11", "ec_number_list": "2.3.1.50", "go_molecular_function": "GO:0004758 serine C-palmitoyltransferase activity;GO:0030170 pyridoxal phosphate binding", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0046511 sphinganine biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0006665 sphingolipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35704-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55098-1", "uniprot_id": "STK10_MOUSE", "mass": 111906.0, "length": 966, "protein_name": "Serine/threonine-protein kinase 10", "gene_name": "Stk10", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase 10 isoform 1", "refseq_ac": "NP_033314", "gene_names_uniprotkb": "Stk10; Lok", "gene_names_refseq": "Gek1; Lok; Stk10; mKIAA4026", "protein_names_uniprotkb": "Serine/threonine-protein kinase 10; 2.7.11.1; Lymphocyte-oriented kinase", "protein_names_refseq": "germ cell kinase 1; lymphocyte-oriented kinase; serine/threonine-protein kinase 10 isoform 1; serine/threonine-protein kinase 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:20868); (R-MMU-6798695); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10692593;12639966;19131326;19144319;19255442;21183079;21952136;27919044;31219806;34418053;34428180;36210013;9278426", "class_list": "", "function": "Kinases, including Slk, Lok and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo., [UniProtKB, PubMed]; Stk10 is a novel polo-like kinase kinase that cooperates with hSlk to regulate Plk1 function in human cells, [RefSeq, PubMed]; These studies identify a new ERM kinase of importance in lymphocytes and confirm the role of ezrin-radixin-moesin phosphorylation in regulating cell shape and motility., [RefSeq, PubMed]; This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Mice deficient for this gene product are viable, but exhibit altered integrin-mediated lymphocyte adhesion characteristics. The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1ATW8", "ec_number_list": "2.7.11.1;2.3.2.27;7.6.2.1;2.7.11.25;3.1.3.48;2.7.11.24;1.14.19.17;5.2.1.-;2.7.12.2;6.2.1.3;6.2.1.-;6.2.1.7;6.2.1.24;6.2.1.15;2.7.12.1;2.7.11.22;3.4.24.81;2.7.10.2;2.7.11.-;2.7.11.4;1.14.14.18;2.7.11.10;2.7.11.11;3.4.21.73;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;3.1.2.-;7.6.2.-;3.6.5.2;1.1.1.-;3.6.4.-;2.7.11.39;2.3.1.-;3.4.24.-;2.3.1.78;2.7.11.31;3.6.5.-;1.6.3.-;3.2.2.6;2.3.1.48;1.2.1.5;1.2.1.28;1.2.1.7;1.2.1.48;4.1.1.32;2.7.11.38;2.3.1.51;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150;3.1.4.4;2.3.1.20;2.3.1.76", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0046777 protein autophosphorylation;GO:0071593 lymphocyte aggregation;GO:2000401 regulation of lymphocyte migration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O55098-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70555-1", "uniprot_id": "SPR2D_MOUSE", "mass": 9243.0, "length": 85, "protein_name": "Small proline-rich protein 2D", "gene_name": "Sprr2d", "organism": "Mouse", "refseq_name": "small proline-rich protein 2D", "refseq_ac": "NP_035600", "gene_names_uniprotkb": "Sprr2d", "gene_names_refseq": "Sprr2d", "protein_names_uniprotkb": "Small proline-rich protein 2D", "protein_names_refseq": "small proline-rich protein 2D", "tax_id": 10090, "disease": "", "pathway": " (mmu:20758)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12584609;15232223;31884525;9888996", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)., [UniProtKB]; Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030141 secretory granule;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation;GO:0032355 response to estradiol;GO:0008585 female gonad development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70555-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70557-1", "uniprot_id": "SPR2F_MOUSE", "mass": 8271.0, "length": 76, "protein_name": "Small proline-rich protein 2F", "gene_name": "Sprr2f", "organism": "Mouse", "refseq_name": "small proline-rich protein 2F", "refseq_ac": "NP_035602", "gene_names_uniprotkb": "Sprr2f", "gene_names_refseq": "Sprr2f", "protein_names_uniprotkb": "Small proline-rich protein 2F", "protein_names_refseq": "small proline-rich protein 2F", "tax_id": 10090, "disease": "", "pathway": " (mmu:20760)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12584609;15232223;33017192;9888996", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)., [UniProtKB]; Sprr2f protects against renal injury by decreasing the level of reactive oxygen species in female mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation;GO:0032355 response to estradiol", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70557-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70560-1", "uniprot_id": "SPR2I_MOUSE", "mass": 8356.0, "length": 76, "protein_name": "Small proline-rich protein 2I", "gene_name": "Sprr2i", "organism": "Mouse", "refseq_name": "small proline-rich protein 2I", "refseq_ac": "NP_035605", "gene_names_uniprotkb": "Sprr2i", "gene_names_refseq": "Sprr2i", "protein_names_uniprotkb": "Small proline-rich protein 2I", "protein_names_refseq": "small proline-rich protein 2I", "tax_id": 10090, "disease": "", "pathway": " (mmu:20763)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12584609;15232223;9888996", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0030141 secretory granule;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70560-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O70561-1", "uniprot_id": "SPR2J_MOUSE", "mass": 11809.0, "length": 109, "protein_name": "Putative small proline-rich protein 2J", "gene_name": "Sprr2j", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sprr2j; Sprr2j-ps", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative small proline-rich protein 2J", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "12584609;15232223;9888996", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0031424 keratinization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70561-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88452-1", "uniprot_id": "STC2_MOUSE", "mass": 32602.0, "length": 296, "protein_name": "Stanniocalcin-2", "gene_name": "Stc2", "organism": "Mouse", "refseq_name": "stanniocalcin-2 precursor", "refseq_ac": "NP_035621", "gene_names_uniprotkb": "Stc2", "gene_names_refseq": "Stc-2; Stc2l; Stc2; mustc2", "protein_names_uniprotkb": "Stanniocalcin-2; STC-2", "protein_names_refseq": "stanniocalcin-2 precursor", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:20856); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10450831;15485913;33011858;34111662;37562971;37568262;9723890", "class_list": "", "function": "Has an anti-hypocalcemic action on calcium and phosphate homeostasis., [UniProtKB]; In Vivo Gene Delivery of STC2 Promotes Axon Regeneration in Sciatic Nerves., [RefSeq, PubMed]; Induced STC2 expression is an essential feature of survival component of the unfolded-protein response, [RefSeq, PubMed]; Role of ERK1/2 Signaling in Cinnabarinic Acid-Driven Stanniocalcin 2-Mediated Protection against Alcohol-Induced Apoptosis., [RefSeq, PubMed]; Stanniocalcin-2 inhibits skeletal muscle growth and is upregulated in functional overload-induced hypertrophy., [RefSeq, PubMed]; Transcriptome-wide profiling discover: PM2.5 aggravates airway dysfunction through epithelial barrier damage regulated by Stanniocalcin 2 in an OVA-induced model., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0005179 hormone activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0010629 negative regulation of gene expression;GO:0006874 intracellular calcium ion homeostasis;GO:0071456 cellular response to hypoxia;GO:0040015 negative regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88452-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DP99-1", "uniprot_id": "STMP1_MOUSE", "mass": 5327.0, "length": 47, "protein_name": "Short transmembrane mitochondrial protein 1", "gene_name": "Stmp1", "organism": "Mouse", "refseq_name": "short transmembrane mitochondrial protein 1", "refseq_ac": "NP_001371164", "gene_names_uniprotkb": "Stmp1; 1810058I24Rik; Mtlbn", "gene_names_refseq": "1810058I24Rik; Mm47; Stmp1", "protein_names_uniprotkb": "Short transmembrane mitochondrial protein 1; Mitochondrial micropeptide-47; Mm47; Protein mitolamban", "protein_names_refseq": "mitochondrial micropeptide-47; protein mitolamban; short transmembrane mitochondrial protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67705)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;31836654;34428180;35101990;36368158", "class_list": "", "function": "Microprotein involved in mitochondrial respiratory chain complex III (ubiquinol-cytochrome c oxidoreductase) and complex IV (mitochondrial cytochrome c oxidase complex) assembly (PubMed:35101990). Required for the formation of mitochondrial supercomplexes (SCs) (PubMed:35101990). Also required for the activation of the NLRP3 inflammasome (PubMed:31836654)., [UniProtKB, PubMed, PubMed]; The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice., [RefSeq, PubMed]; The mitochondrial micropeptide Stmp1 promotes retinal cell differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A5F8MPG2;Q3TAI1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0098803 respiratory chain complex", "go_biological_process": "GO:0045087 innate immune response;GO:0032731 positive regulation of interleukin-1 beta production;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0DP99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42228-1", "uniprot_id": "STAT4_MOUSE", "mass": 85941.0, "length": 749, "protein_name": "Signal transducer and activator of transcription 4", "gene_name": "Stat4", "organism": "Mouse", "refseq_name": "signal transducer and activator of transcription 4", "refseq_ac": "NP_001295195", "gene_names_uniprotkb": "Stat4", "gene_names_refseq": "Stat4", "protein_names_uniprotkb": "Signal transducer and activator of transcription 4", "protein_names_refseq": "signal transducer and activator of transcription 4", "tax_id": 10090, "disease": "polymyositis (Disease Ontology:DOID:0080745); disabling pansclerotic morphea (Disease Ontology:DOID:0081373); dermatomyositis (Disease Ontology:DOID:10223); primary biliary cholangitis (Disease Ontology:DOID:12236); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); Sjogren's syndrome (Disease Ontology:DOID:12894); Behcet's disease (Disease Ontology:DOID:13241); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); viral hepatitis (Disease Ontology:DOID:1884); rectum adenocarcinoma (Disease Ontology:DOID:1996); autoimmune hepatitis (Disease Ontology:DOID:2048); IgA glomerulonephritis (Disease Ontology:DOID:2986); systemic scleroderma (Disease Ontology:DOID:418); hepatocellular carcinoma (Disease Ontology:DOID:684); Sezary's disease (Disease Ontology:DOID:8541); cholesteatoma (Disease Ontology:DOID:869); genital herpes (Disease Ontology:DOID:8704); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:20849); (R-MMU-8854691); (R-MMU-8984722); (R-MMU-9020591); (R-MMU-9020933); (R-MMU-9020958)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10961885;14734615;18234692;19224205;20173027;30084848;30779550;31599954;34138758;34428180;35820727;36210013;7545930;8007943;8700209;9461439", "class_list": "", "function": "The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Homozygous knockout mice for this gene exhibit reduced inflammation and cytokine production in response to immune challenge. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]; Transcriptional regulator mainly expressed in hematopoietic cells that plays a critical role in cellular growth, differentiation and immune response. Plays a key role in the differentiation of T-helper 1 cells and the production of interferon-gamma (PubMed:8700209). Also participates in multiple neutrophil functions including chemotaxis and production of the neutrophil extracellular traps (PubMed:34138758). After IL12 binding to its receptor IL12RB2, STAT4 interacts with the intracellular domain of IL12RB2 and becomes tyrosine phosphorylated. Phosphorylated STAT4 then homodimerizes and migrates to the nucleus where it can recognize STAT target sequences present in IL12 responsive genes. Although IL12 appears to be the predominant activating signal, STAT4 can also be phosphorylated and activated in response to IFN-gamma stimulation via JAK1 and TYK2 and in response to different interleukins including IL23, IL2 and IL35 (By similarity). Transcription activation of IFN-gamma gene is mediated by interaction with JUN that forms a complex that efficiently interacts with the AP-1-related sequence of the IFN-gamma promoter (PubMed:14734615). In response to IFN-alpha/beta signaling, acts as a transcriptional repressor and suppresses IL5 and IL13 mRNA expression during response to T-cell receptor (TCR) activation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0006952 defense response", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P42228-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49891-1", "uniprot_id": "ST1E1_MOUSE", "mass": 35590.0, "length": 295, "protein_name": "Sulfotransferase 1E1", "gene_name": "Sult1e1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sult1e1; Est; Ste", "gene_names_refseq": "", "protein_names_uniprotkb": "Sulfotransferase 1E1; 2.8.2.4; Estrogen sulfotransferase, testis isoform; ST1E1; Sulfotransferase, estrogen-preferring", "protein_names_refseq": "", "tax_id": 10090, "disease": "endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (R-MMU-156584); (R-MMU-9753281)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "7750469;9360604;9765259", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (By similarity) (PubMed:9765259). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone, pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-;2.8.2.14;2.8.2.2;2.8.2.n2;2.8.2.4;2.8.2.1", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0004304 estrone sulfotransferase activity;GO:0047894 flavonol 3-sulfotransferase activity;GO:0050294 steroid sulfotransferase activity;GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0051923 sulfation;GO:0006711 estrogen catabolic process;GO:0045600 positive regulation of fat cell differentiation;GO:0006068 ethanol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P49891-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UZZ6-1", "uniprot_id": "ST1D1_MOUSE", "mass": 35083.0, "length": 295, "protein_name": "Sulfotransferase 1 family member D1", "gene_name": "Sult1d1", "organism": "Mouse", "refseq_name": "sulfotransferase 1 family member D1", "refseq_ac": "NP_058051", "gene_names_uniprotkb": "Sult1d1; St1d1", "gene_names_refseq": "5033411P13Rik; ST1d1; SULT-N; Sult1d1; Sultn", "protein_names_uniprotkb": "Sulfotransferase 1 family member D1; 2.8.2.-; Amine N-sulfotransferase; Dopamine sulfotransferase Sult1d1; ST1D1; SULT-N; Tyrosine-ester sulfotransferase", "protein_names_refseq": "N-sulfotransferase; amine N-sulfotransferase; dopamine sulfotransferase Sult1d1; sulfotransferase 1 family member D1; tyrosine-ester sulfotransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:53315)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15087475;18977225;19073143;19344693;19966186;29908303;30084848;34428180;37507081;9647753;9920733", "class_list": "", "function": "Data obtained indicated that mSULT1D1 comprises of a single alpha/beta domain with a five-stranded parallel beta-sheet., [RefSeq, PubMed]; Sulfotransferase with broad substrate specificity that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, such as dopamine, prostaglandins, leukotriene E4, drugs and xenobiotic compounds. Has sulfotransferase activity towards p-nitrophenol, 2-naphthylamine and minoxidil (in vitro). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Sult1d1 knockout did not influence furfuryl alcohol bioactivation or the formation of hemoglobin adducts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35401;Q6NZD1;Q9R2C2", "ec_number_list": "", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051923 sulfation;GO:0006629 lipid metabolic process;GO:0006584 catecholamine metabolic process;GO:0000103 sulfate assimilation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q3UZZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q60969-1", "uniprot_id": "STYX_MOUSE", "mass": 25430.0, "length": 223, "protein_name": "Serine/threonine/tyrosine-interacting protein", "gene_name": "Styx", "organism": "Mouse", "refseq_name": "serine/threonine/tyrosine-interacting protein", "refseq_ac": "NP_062611", "gene_names_uniprotkb": "Styx", "gene_names_refseq": "0610039A20Rik; Styx; hStyxb", "protein_names_uniprotkb": "Serine/threonine/tyrosine-interacting protein; Inactive tyrosine-protein phosphatase Styx; Phosphoserine/threonine/tyrosine interaction protein", "protein_names_refseq": "inactive tyrosine-protein phosphatase Styx; phosphoserine/threonine/tyrosine interaction protein; protein tyrosine phosphatase-like protein; protein tyrosine phosphatase-like unspliced c-terminal product and spliced c-terminal end STYX; serine/threonine/tyrosine-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:56291)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11842224;21750661;22645316;35338113;7592916", "class_list": "", "function": "Catalytically inactive phosphatase (PubMed:7592916). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (By similarity). Plays a role in spermatogenesis (PubMed:11842224)., [UniProtKB, PubMed, UniProtKB, PubMed]; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates. Plays a role in spermatogenesis., [UniProtKB, UniProtKB]; Pseudophosphatase STYX is induced by Helicobacter pylori and promotes gastric cancer progression by inhibiting FBXO31 function. Publication Status: Online-Only, [RefSeq, PubMed]; We demonstrate that the phosphoserine, -threonine or -tyrosine, interaction protein, Styx, complexes with a testicular RNA-binding protein and is essential for normal spermiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMA3;Q60970;Q9DCF8", "ec_number_list": "", "go_molecular_function": "GO:1990444 F-box domain binding;GO:0001691 pseudophosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007283 spermatogenesis;GO:0070372 regulation of ERK1 and ERK2 cascade;GO:0062026 negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q60969-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62186-1", "uniprot_id": "SSRD_MOUSE", "mass": 18937.0, "length": 172, "protein_name": "Translocon-associated protein subunit delta", "gene_name": "Ssr4", "organism": "Mouse", "refseq_name": "translocon-associated protein subunit delta isoform 2 precursor", "refseq_ac": "NP_033305", "gene_names_uniprotkb": "Ssr4", "gene_names_refseq": "SSR-delta; Ssr4; TRAP-delta; Trap", "protein_names_uniprotkb": "Translocon-associated protein subunit delta; SSR-delta; Signal sequence receptor subunit delta; TRAP-delta", "protein_names_refseq": "signal sequence receptor subunit delta; translocon-associated protein subunit delta isoform 2 precursor; translocon-associated protein subunit delta", "tax_id": 10090, "disease": "congenital disorder of glycosylation Iy (Disease Ontology:DOID:0080574)", "pathway": " (mmu:20832)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "34428180;35820727;37453647;37828378;7492314", "class_list": "", "function": "TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0012505 endomembrane system;GO:0005784 Sec61 translocon complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62186-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62266-1", "uniprot_id": "SPR1A_MOUSE", "mass": 15765.0, "length": 144, "protein_name": "Cornifin-A", "gene_name": "Sprr1a", "organism": "Mouse", "refseq_name": "cornifin-A", "refseq_ac": "NP_033290", "gene_names_uniprotkb": "Sprr1a", "gene_names_refseq": "SPR1a; Sprr1a; mSPRR1A", "protein_names_uniprotkb": "Cornifin-A; SPR1 A; SPR1A; Small proline-rich protein 1A", "protein_names_refseq": "SPR1 A; cornifin-A", "tax_id": 10090, "disease": "", "pathway": " (mmu:20753)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "37453647;37468478;39627609;8601731;9931436", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. May participate widely in the construction of cell envelopes in cornifying epithelia characterized by either increased thickness or a requirement for extreme flexibility., [UniProtKB]; SPRR1A is a key downstream effector of MiR-150 during both maladaptive cardiac remodeling in mice and human cardiac fibroblast activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMN4", "ec_number_list": "", "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0071944 cell periphery;GO:0001533 cornified envelope", "go_biological_process": "GO:0030216 keratinocyte differentiation;GO:0018149 peptide cross-linking;GO:0070268 cornification", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62266-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62267-1", "uniprot_id": "SPR1B_MOUSE", "mass": 16636.0, "length": 153, "protein_name": "Cornifin-B", "gene_name": "Sprr1b", "organism": "Mouse", "refseq_name": "cornifin-B", "refseq_ac": "NP_033291", "gene_names_uniprotkb": "Sprr1b", "gene_names_refseq": "Sprr1b", "protein_names_uniprotkb": "Cornifin-B; SPR1 B; SPR1B; Small proline-rich protein 1B", "protein_names_refseq": "SPR1 B; SPR1B; cornifin-B", "tax_id": 10090, "disease": "", "pathway": " (mmu:20754)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12832281;8601731;9931436", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane., [UniProtKB]; SPRR1B expression pattern in nonsquamous tumors; findings indicate SPRR1B likely coupled to signals responsible for withdrawal from the proliferative state; overexpression for prolonged periods may disrupt normal progression of mitosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VEC0", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization;GO:0030216 keratinocyte differentiation;GO:0008360 regulation of cell shape;GO:0018149 peptide cross-linking", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62267-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62270-1", "uniprot_id": "SRMS_MOUSE", "mass": 55758.0, "length": 496, "protein_name": "Tyrosine-protein kinase Srms", "gene_name": "Srms", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Srms; Srm", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase Srms; 2.7.10.2; PTK70", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-8849472)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "34428180;7935409;9226137", "class_list": "", "function": "Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent. Phosphorylates OTUB1, promoting deubiquitination of RPTOR., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62360;Q923M5", "ec_number_list": "2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.40;2.7.11.23", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0016579 protein deubiquitination;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62270-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q68FG3-1", "uniprot_id": "SPT2_MOUSE", "mass": 74818.0, "length": 682, "protein_name": "Protein SPT2 homolog", "gene_name": "Spty2d1", "organism": "Mouse", "refseq_name": "protein SPT2 homolog", "refseq_ac": "NP_780527", "gene_names_uniprotkb": "Spty2d1", "gene_names_refseq": "5830435K17Rik; P16H6; Spty2d1", "protein_names_uniprotkb": "Protein SPT2 homolog; SPT2 domain-containing protein 1", "protein_names_refseq": "SPT2 domain-containing protein 1; SPT2, Suppressor of Ty, domain containing 1; protein SPT2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:101685)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIR1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042393 histone binding;GO:0001042 RNA polymerase I core binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0006355 regulation of DNA-templated transcription;GO:0006334 nucleosome assembly;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q68FG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q69ZS6-1", "uniprot_id": "SV2C_MOUSE", "mass": 82291.0, "length": 727, "protein_name": "Synaptic vesicle glycoprotein 2C", "gene_name": "Sv2c", "organism": "Mouse", "refseq_name": "synaptic vesicle glycoprotein 2C", "refseq_ac": "NP_083486", "gene_names_uniprotkb": "Sv2c; Kiaa1054", "gene_names_refseq": "4930527L09Rik; Sv2c", "protein_names_uniprotkb": "Synaptic vesicle glycoprotein 2C; Synaptic vesicle protein 2C", "protein_names_refseq": "synaptic vesicle glycoprotein 2C; synaptic vesicle protein 2C", "tax_id": 10090, "disease": "", "pathway": " (mmu:75209)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11483953;12687700;16543415;16545378;18815274;20485683;21483489;21632541;29713895;30899004;33300544;38532289", "class_list": "", "function": "(Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD) (PubMed:21483489)., [UniProtKB, PubMed]; (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin binds Sv2c via extracellular loop 4 (PubMed:16543415)., [UniProtKB, PubMed, PubMed]; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles., [UniProtKB, UniProtKB]; Study showed that SV2C is highly expressed in the basal ganglia and hippocampus of mice and that there is a specific and progressive decrease in SV2C mRNA and protein expression in both Huntington's disease (HD) mice and a cell model. These findings suggest that the synaptic dysfunction in HD results from the mutant Htt-mediated inhibition of SV2C transcriptional expression., [RefSeq, PubMed]; Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle;GO:0098691 dopaminergic synapse", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0090394 negative regulation of excitatory postsynaptic potential;GO:0006836 neurotransmitter transport;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q69ZS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TMF5-1", "uniprot_id": "SPA12_MOUSE", "mass": 47634.0, "length": 413, "protein_name": "Serpin A12", "gene_name": "Serpina12", "organism": "Mouse", "refseq_name": "serpin A12 precursor", "refseq_ac": "NP_080811", "gene_names_uniprotkb": "Serpina12", "gene_names_refseq": "4632419J12Rik; Serpina12", "protein_names_uniprotkb": "Serpin A12; Vaspin; Visceral adipose tissue-derived serine protease inhibitor; Visceral adipose-specific serpin", "protein_names_refseq": "serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12; serpin A12 precursor; serpin A12; vaspin; visceral adipose tissue-derived serine protease inhibitor; visceral adipose-specific SERPIN", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:68054)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16030142;18800627;22837305;23370777;31505214;32964986;33742129;34428180;36630996;37921063", "class_list": "", "function": "A Vaspin-HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]; Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues., [UniProtKB, PubMed, PubMed]; Data suggest that vaspin is ligand for cell-surface GRP78 (glucose-regulated protein 78kD)/MTJ-1 (DnaJ-like protein 1) complex; subsequent signal transduction benefits endoplasmic reticulum stress-induced metabolic dysfunctions as seen in obesity., [RefSeq, PubMed]; LRP1 is the cell-surface endocytosis receptor for vaspin in adipocytes., [RefSeq, PubMed]; May be the compensatory molecule in the pathogenesis of metabolic syndrome. (review) Review article, [RefSeq, PubMed]; SERPINA12 promotes the tumorigenic capacity of HCC stem cells through hyperactivation of AKT/beta-catenin signaling., [RefSeq, PubMed]; These results suggest that C/EBPalpha positively regulates hepatic vaspin expression through two functional CEBPREs. Thus, vaspin is a novel C/EBPalpha target gene in the liver., [RefSeq, PubMed]; VASPIN reduces inflammation and endoplasmic reticulum stress of renal tubular epithelial cells by inhibiting HMGB1 and relieves renal ischemia-reperfusion injury., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQ32", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0090181 regulation of cholesterol metabolic process;GO:0045721 negative regulation of gluconeogenesis;GO:0046628 positive regulation of insulin receptor signaling pathway;GO:0051055 negative regulation of lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7TMF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGW6-1", "uniprot_id": "ST32A_MOUSE", "mass": 46509.0, "length": 398, "protein_name": "Serine/threonine-protein kinase 32A", "gene_name": "Stk32a", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase 32A", "refseq_ac": "NP_848864", "gene_names_uniprotkb": "Stk32a", "gene_names_refseq": "A930015B13Rik; Stk32a; YANK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase 32A; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase 32A", "tax_id": 10090, "disease": "", "pathway": " (mmu:269019)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17660561;21750661;37144879", "class_list": "", "function": "Probable serine/threonine kinase with currently unidentified substrates. In the inner ear, functions as a planar cell polarity (PCP) factor acting antagonistically to EMX2. It regulates the orientation of stereociliary bundles in hair cells by interacting with the PCP signaling pathway in opposition to EMX2 (PubMed:37144879). Additionally, it may play a role in controlling the apical localization of the GPR156 receptor in inner ear hair cells (PubMed:37144879)., [UniProtKB, PubMed]; The dark kinase STK32A regulates hair cell planar polarity opposite of EMX2 in the developing mouse inner ear. Publication Status: Online-Only, [RefSeq, PubMed]; Transcripts highly enriched in ovary; gene identified as candidate female fertility factor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPQ4", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BGW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHW6-1", "uniprot_id": "SPT21_MOUSE", "mass": 75541.0, "length": 681, "protein_name": "Spermatogenesis-associated protein 21", "gene_name": "Spata21", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 21", "refseq_ac": "NP_808535", "gene_names_uniprotkb": "Spata21", "gene_names_refseq": "4933414G08; Spata21", "protein_names_uniprotkb": "Spermatogenesis-associated protein 21", "protein_names_refseq": "spermatogenesis-associated protein 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:329972)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "Involved in the differentiation of haploid spermatids., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BHW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BV57-1", "uniprot_id": "SRCRL_MOUSE", "mass": 144637.0, "length": 1371, "protein_name": "Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D", "gene_name": "Ssc5d", "organism": "Mouse", "refseq_name": "soluble scavenger receptor cysteine-rich domain-containing protein SSC5D precursor", "refseq_ac": "NP_766596", "gene_names_uniprotkb": "Ssc5d; S5D-SRCRB", "gene_names_refseq": "A430110N23Rik; S5D-SRCRB; Ssc5d", "protein_names_uniprotkb": "Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D; Scavenger receptor cysteine-rich domain-containing protein LOC284297 homolog", "protein_names_refseq": "group B scavenger receptor cysteine-rich domain-containing; scavenger receptor cysteine rich domain containing (5 domains); scavenger receptor cysteine-rich domain-containing protein LOC284297 homolog; soluble scavenger receptor cysteine-rich domain-containing protein SSC5D precursor; soluble scavenger receptor cysteine-rich domain-containing protein SSC5D", "tax_id": 10090, "disease": "", "pathway": " (mmu:269855)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21217009;24641504;31219806", "class_list": "", "function": "Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces., [UniProtKB, PubMed]; Group B scavenger receptor protein S5D-SRCRB might play a role in innate defense and homeostasis of certain specialized epithelial surfaces., [RefSeq, PubMed]; The results indicate that S5D-SRCRB is an integral component of the urogenital tract involved in innate immune functions., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B2RUB0;C6ZFQ2;Q3TMW2", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0043236 laminin binding;GO:0050840 extracellular matrix binding;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0042494 detection of bacterial lipoprotein;GO:0006952 defense response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BV57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C3L1-1", "uniprot_id": "SSUH2_MOUSE", "mass": 38544.0, "length": 340, "protein_name": "Protein SSUH2 homolog", "gene_name": "Ssu2; Ssuh2", "organism": "Mouse", "refseq_name": "protein SSUH2 homolog isoform 1", "refseq_ac": "NP_780734", "gene_names_uniprotkb": "Ssu2; Ssuh2; Ssu2", "gene_names_refseq": "D630042P16Rik; Fls485; Ssu2; Ssuh2", "protein_names_uniprotkb": "Protein SSUH2 homolog; Protein ssu-2 homolog", "protein_names_refseq": "protein SSUH2 homolog isoform 1; protein SSUH2 homolog; protein ssu-2 homolog", "tax_id": 10090, "disease": "dentin dysplasia (Disease Ontology:DOID:701)", "pathway": " (mmu:243612)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;27680507", "class_list": "", "function": "Plays a role in odontogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q14AZ1", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042476 odontogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C3L1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CD78-1", "uniprot_id": "SRTM1_MOUSE", "mass": 11392.0, "length": 107, "protein_name": "Serine-rich and transmembrane domain-containing protein 1", "gene_name": "Sertm1", "organism": "Mouse", "refseq_name": "serine-rich and transmembrane domain-containing protein 1", "refseq_ac": "NP_808522", "gene_names_uniprotkb": "Sertm1", "gene_names_refseq": "6030405A18Rik; Sertm1", "protein_names_uniprotkb": "Serine-rich and transmembrane domain-containing protein 1", "protein_names_refseq": "serine-rich and transmembrane domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:329641)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CD78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K4T3-1", "uniprot_id": "STRAB_MOUSE", "mass": 46832.0, "length": 418, "protein_name": "STE20-related kinase adapter protein beta", "gene_name": "Stradb", "organism": "Mouse", "refseq_name": "STE20-related kinase adapter protein beta", "refseq_ac": "NP_766244", "gene_names_uniprotkb": "Stradb; Als2cr2; Papk; Syradb", "gene_names_refseq": "Als2cr2; B830008M19; D1Ucla2; ILPIPA; ILPIP; PRO1038; Papk; Stradb; Syradb", "protein_names_uniprotkb": "STE20-related kinase adapter protein beta; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog; ILP-interacting protein homolog; Polyploidy-associated protein kinase; Pseudokinase ALS2CR2; STRAD beta", "protein_names_refseq": "ILP-interacting protein homolog; STE20-related kinase adapter protein beta; STRAD beta; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog; polyploidy associated protein kinase; pseudokinase ALS2CR2", "tax_id": 10090, "disease": "", "pathway": " (mmu:227154); (R-MMU-380972)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12574163;21750661;21903876;30084848;31219806;34428180", "class_list": "", "function": "Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Quantitative PCR revealed significantly reduced LKB1, MO25alpha, and STRADbeta mRNA in LKB1(-/-) muscle. These findings demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK in skeletal muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P922;Q8BU86;Q8BXK0;Q8K4T2", "ec_number_list": "", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007254 JNK cascade;GO:0000902 cell morphogenesis;GO:0007010 cytoskeleton organization;GO:0032147 activation of protein kinase activity;GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K4T3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R054-1", "uniprot_id": "SRPX2_MOUSE", "mass": 53140.0, "length": 468, "protein_name": "Sushi repeat-containing protein SRPX2", "gene_name": "Srpx2", "organism": "Mouse", "refseq_name": "sushi repeat-containing protein SRPX2 precursor", "refseq_ac": "NP_001077364", "gene_names_uniprotkb": "Srpx2", "gene_names_refseq": "1110039C07Rik; SRPUL; SRP; Srpx2", "protein_names_uniprotkb": "Sushi repeat-containing protein SRPX2", "protein_names_refseq": "sushi repeat-containing protein SRPX2 precursor; sushi repeat-containing protein SRPX2; sushi-repeat containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:68792)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19667118;24179158;31362033;32661396;34762332", "class_list": "", "function": "Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations., [UniProtKB, PubMed, PubMed]; C1q and SRPX2 regulate microglia mediated synapse elimination during early development in the visual thalamus but not the visual cortex., [RefSeq, PubMed]; The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development., [RefSeq, PubMed]; Unsupervised hierarchical clustering using SRPX2 expression did not identify genotype or injury-specific clusters. Data demonstrate that SRPX2 expression in the hypothalamus is resistant to genetic deficiencies in the urokinase-system or to the hypothalamus-affecting TBI., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AVI6;Q3UVU0;Q8K1F8;Q8K4W6", "ec_number_list": "", "go_molecular_function": "GO:0036458 hepatocyte growth factor binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001525 angiogenesis;GO:0098609 cell-cell adhesion;GO:0051965 positive regulation of synapse assembly;GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis;GO:0051963 regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R054-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0L1-1", "uniprot_id": "STAP2_MOUSE", "mass": 45802.0, "length": 411, "protein_name": "Signal-transducing adaptor protein 2", "gene_name": "Stap2", "organism": "Mouse", "refseq_name": "signal-transducing adaptor protein 2 isoform 1", "refseq_ac": "NP_666046", "gene_names_uniprotkb": "Stap2", "gene_names_refseq": "STAP-2; Stap2", "protein_names_uniprotkb": "Signal-transducing adaptor protein 2; STAP-2", "protein_names_refseq": "signal-transducing adaptor protein 2 isoform 1; signal-transducing adaptor protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:106766); (R-MMU-8849474)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12540842;15611091;17368569;17512498;17675501;22231445;30084848;33388414;34358967;34428180;35725273;37669828;38461189", "class_list": "", "function": "Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic mice., [RefSeq, PubMed]; STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals., [RefSeq, PubMed]; STAP-2 associates with FAK and enhances its degradation, proteasome inhibitors block FAK degradation, and STAP-2 recruits an endogenous E3 ubiquitin ligase, Cbl, to FAK., [RefSeq, PubMed]; STAP-2 directly binds to c-Fms and interferes with the PI3K signaling, which leads to macrophage motility, in Raw 264.7 cells, [RefSeq, PubMed]; STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN., [RefSeq, PubMed]; STAP-2/BKS is a modulator of STAT5-mediated signaling, [RefSeq, PubMed]; Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation., [RefSeq, PubMed]; Substrate of protein kinase PTK6 (By similarity). May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWS2", "ec_number_list": "", "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8R0L1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4Y4-1", "uniprot_id": "STAB1_MOUSE", "mass": 276257.0, "length": 2571, "protein_name": "Stabilin-1", "gene_name": "Stab1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Stab1; Feel1", "gene_names_refseq": "", "protein_names_uniprotkb": "Stabilin-1; FEEL-1; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:192187); (R-MMU-3000497)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11829752;21750661;34105348;34428180;40885482", "class_list": "", "function": "Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 20, "predicted_n_glycosites": 19, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 12, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 12, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 12, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 12, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 0, "glyco_site_count": 34, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0K6;Q8VC09", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005509 calcium ion binding;GO:0005041 low-density lipoprotein particle receptor activity;GO:0030169 low-density lipoprotein particle binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0007267 cell-cell signaling;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q8R4Y4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCC9-1", "uniprot_id": "SPON1_MOUSE", "mass": 90821.0, "length": 807, "protein_name": "Spondin-1", "gene_name": "Spon1", "organism": "Mouse", "refseq_name": "spondin-1 precursor", "refseq_ac": "NP_663559", "gene_names_uniprotkb": "Spon1", "gene_names_refseq": "D330035F22Rik; FSP; Spon1", "protein_names_uniprotkb": "Spondin-1; F-spondin", "protein_names_refseq": "F-spondin; spondin-1 precursor; spondin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:233744); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "30899004;34428180", "class_list": "", "function": "Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2Q8", "ec_number_list": "", "go_molecular_function": "GO:0050693 LBD domain binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:1902430 negative regulation of amyloid-beta formation;GO:0010954 positive regulation of protein processing;GO:1902993 positive regulation of amyloid precursor protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VCC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924S8-1", "uniprot_id": "SPRE1_MOUSE", "mass": 50664.0, "length": 444, "protein_name": "Sprouty-related, EVH1 domain-containing protein 1", "gene_name": "Spred1", "organism": "Mouse", "refseq_name": "sprouty-related, EVH1 domain-containing protein 1 isoform 2", "refseq_ac": "NP_001264185", "gene_names_uniprotkb": "Spred1", "gene_names_refseq": "5730461F13Rik; Spred1", "protein_names_uniprotkb": "Sprouty-related, EVH1 domain-containing protein 1; Spred-1", "protein_names_refseq": "sprouty-related protein 1 with EVH-1 domain; sprouty-related, EVH1 domain-containing protein 1 isoform 2; sprouty-related, EVH1 domain-containing protein 1", "tax_id": 10090, "disease": "Legius syndrome (Disease Ontology:DOID:0070484)", "pathway": " (mmu:114715); (R-MMU-5658442); (R-MMU-5658623)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "11493923;12646235;15184877;15465815;15580519;17974561;19144319;21183079;22645316;24705354;25428506;25576668;29501879;32848054;34564700;40885482", "class_list": "", "function": "Role in hematopoiesis, [RefSeq, PubMed]; Spred-1 and Spred-2 were found to be expressed predominantly in brain, [RefSeq, PubMed]; Spred1 deficit promotes treatment resistance and transformation of chronic phase CML., [RefSeq, PubMed]; These data suggest that Spreds are key regulators of RhoA-mediated cell motility and signal transduction. Furthermore, our study suggests that the induction of Spreds could be a novel strategy for preventing cancer cell metastasis., [RefSeq, PubMed]; This gene encodes a membrane-associated protein that is phosphorylated by tyrosine kinases in response to growth factors. The encoded protein acts as a negative regulator of the mitogen-activated protein (MAP) kinase signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]., [RefSeq]; Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (PubMed:11493923). Negatively regulates hematopoiesis of bone marrow (PubMed:15465815). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (PubMed:25576668)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2W6;Q6PET8", "ec_number_list": "", "go_molecular_function": "GO:0005173 stem cell factor receptor binding;GO:0019901 protein kinase binding;GO:0019902 phosphatase binding;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:1902532 negative regulation of intracellular signal transduction;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0016525 negative regulation of angiogenesis;GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q924S8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q925E8-1", "uniprot_id": "SPTSB_MOUSE", "mass": 9108.0, "length": 76, "protein_name": "Serine palmitoyltransferase small subunit B", "gene_name": "Sptssb", "organism": "Mouse", "refseq_name": "serine palmitoyltransferase small subunit B isoform a", "refseq_ac": "NP_001157682", "gene_names_uniprotkb": "Sptssb; Admp; Sssptb", "gene_names_refseq": "1110032A04Rik; ADMP; Sptssb; Sssptb", "protein_names_uniprotkb": "Serine palmitoyltransferase small subunit B; Protein ADMP; Small subunit of serine palmitoyltransferase B; ssSPTb", "protein_names_refseq": "androgen down regulated in mouse prostate; serine palmitoyltransferase small subunit B isoform a; small subunit of serine palmitoyltransferase B", "tax_id": 10090, "disease": "", "pathway": " (mmu:66183); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15777716;26438849", "class_list": "", "function": "ADMP (androgen down regulated gene expressed in mouse prostate) expression appears to be androgen-dependent in the kidney and brain of normal intact mouse suggesting tissue specific regulation by androgens., [RefSeq, PubMed]; Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004758 serine C-palmitoyltransferase activity", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0046512 sphingosine biosynthetic process;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q925E8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99KH8-1", "uniprot_id": "STK24_MOUSE", "mass": 47954.0, "length": 431, "protein_name": "Serine/threonine-protein kinase 24", "gene_name": "Stk24", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase 24", "refseq_ac": "NP_663440", "gene_names_uniprotkb": "Stk24; Mst3; Stk3", "gene_names_refseq": "1810013H02Rik; MST-3; Mst3; STE20; Stk24", "protein_names_uniprotkb": "Serine/threonine-protein kinase 24; 2.7.11.1; MST-3; MST3/C; MST3/N; Mammalian STE20-like protein kinase 3 C-terminal; Mammalian STE20-like protein kinase 3 N-terminal; Mammalian STE20-like protein kinase 3; STE20-like kinase MST3", "protein_names_refseq": "STE20-like kinase MST3; mammalian STE20-like protein kinase 3; mammalian sterile twenty 3 kinase; serine/threonine kinase 24 (STE20 homolog, yeast); serine/threonine-protein kinase 24", "tax_id": 10090, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669)", "pathway": " (mmu:223255); (R-MMU-111465); (R-MMU-75153)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19131326;20173027;24872548;25428506;30084848;34428180;36840407;37155619;38229183", "class_list": "", "function": "Epithelial polarization in the 3D matrix requires MST3 signaling to regulate ZO-1 position. Publication Status: Online-Only, [RefSeq, PubMed]; Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis., [RefSeq, PubMed]; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Also regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB]; Sterile 20-like kinase 3 promotes tick-borne encephalitis virus assembly by interacting with NS2A and prM and enhancing the NS2A-NS4A association., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;3.4.22.56;2.3.1.-;3.4.22.60;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0048679 regulation of axon regeneration;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99KH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99MY0-1", "uniprot_id": "SPZ1_MOUSE", "mass": 43091.0, "length": 378, "protein_name": "Spermatogenic leucine zipper protein 1", "gene_name": "Spz1", "organism": "Mouse", "refseq_name": "spermatogenic leucine zipper protein 1", "refseq_ac": "NP_084513", "gene_names_uniprotkb": "Spz1", "gene_names_refseq": "1700027M20Rik; Spz1", "protein_names_uniprotkb": "Spermatogenic leucine zipper protein 1; BHLH-Zip transcription factor SPZ1; Spermatogenic Zip 1", "protein_names_refseq": "bhlh-zip transcription factor SPZ1; spermatogenic Zip 1; spermatogenic leucine zipper protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:79401)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11165476;14980513;15226296;15899793;25428506", "class_list": "", "function": "Spz1 has a regulatory role during spermatogenesis., [RefSeq, PubMed]; The interaction between Spz1 and PP1cgamma2 may be required for proper regulation of spermatogenesis and fertility in males, [RefSeq, PubMed]; Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine-rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V487;Q80X69", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99MY0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CVW4-1", "uniprot_id": "SPT45_MOUSE", "mass": 11413.0, "length": 97, "protein_name": "Spermatogenesis-associated protein 45", "gene_name": "Spata45", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 45", "refseq_ac": "NP_083612", "gene_names_uniprotkb": "Spata45", "gene_names_refseq": "1700022P22Rik; Spata45", "protein_names_uniprotkb": "Spermatogenesis-associated protein 45", "protein_names_refseq": "UPF0732 protein C1orf227 homolog; spermatogenesis-associated protein 45", "tax_id": 10090, "disease": "", "pathway": " (mmu:75558)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CVW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2H6-1", "uniprot_id": "SP2_MOUSE", "mass": 64908.0, "length": 612, "protein_name": "Transcription factor Sp2", "gene_name": "Sp2", "organism": "Mouse", "refseq_name": "transcription factor Sp2 isoform 2", "refseq_ac": "NP_001074433", "gene_names_uniprotkb": "Sp2; Kiaa0048", "gene_names_refseq": "4930480I16Rik; Sp2; mKIAA0048", "protein_names_uniprotkb": "Transcription factor Sp2", "protein_names_refseq": "transcription factor Sp2 isoform 2; transcription factor Sp2", "tax_id": 10090, "disease": "", "pathway": " (mmu:78912)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "20173027;21606357;27191968;29187734;30337366;32001437;32782141;36852467;40885482;40997131", "class_list": "", "function": "A mechanism by which the DNA binding-independent activity of Sp2 potentiates genomic loading of Pbx1:Prep1 and Nf-y to composite motifs present in many promoters of highly expressed genes, [RefSeq, PubMed]; Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites., [UniProtKB]; SP2 as important factor responsible for higher Cd14 expression and reduced IBD susceptibility mediated by the C3Bir allele. Publication Status: Online-Only, [RefSeq, PubMed]; There is a stage-specific requirement for Sp2 in neural stem and progenitor cells in the mouse cortex Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. The protein can act as a transcriptional activator or repressor, depending on the promoter and cell type. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6A0E1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0072359 circulatory system development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9D2H6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPT5-1", "uniprot_id": "SO2A1_MOUSE", "mass": 70147.0, "length": 643, "protein_name": "Solute carrier organic anion transporter family member 2A1", "gene_name": "Slco2a1", "organism": "Mouse", "refseq_name": "solute carrier organic anion transporter family member 2A1", "refseq_ac": "NP_201571", "gene_names_uniprotkb": "Slco2a1; Oatp2a1; Slc21a2", "gene_names_refseq": "2310021C19Rik; OATP2A1; PHOAR2; Pgt; Slc21a2; Slco2a1", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 2A1; OATP2A1; PGT; PHOAR2; Prostaglandin transporter; SLC21A2; SLCO2A1; Solute carrier family 21 member 2", "protein_names_refseq": "solute carrier family 21 (prostaglandin transporter), member 2; solute carrier organic anion transporter family member 2A1", "tax_id": 10090, "disease": "primary hypertrophic osteoarthropathy (Disease Ontology:DOID:14283)", "pathway": " (mmu:24059); (R-MMU-879518)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10484490;17498705;18579702;20083684;26474801;26692285;27169804;29046334;31599954;32442363;34203471;34428180;35299026;38372137", "class_list": "", "function": "Mediates the transport of prostaglandins (PGs, mainly PGE2, PGE1, PGE3, PGF2alpha, PGD2, PGH2) and thromboxanes (thromboxane B2) across the cell membrane (Probable) (PubMed:10484490). PGs and thromboxanes play fundamental roles in diverse functions such as intraocular pressure, gastric acid secretion, renal salt and water transport, vascular tone, and fever (By similarity). Plays a role in the clearance of PGs from the circulation through cellular uptake, which allows cytoplasmic oxidation and PG signal termination (Probable) (PubMed:10484490). PG uptake is dependent upon membrane potential and involves exchange of a monovalent anionic substrate (PGs exist physiologically as an anionic monovalent form) with a stoichiometry of 1:1 for divalent anions or of 1:2 for monovalent anions (By similarity). Uses lactate, generated by glycolysis, as a counter-substrate to mediate PG influx and efflux. Under nonglycolytic conditions, metabolites other than lactate might serve as counter-substrates. Although the mechanism is not clear, this transporter can function in bidirectional mode (By similarity). When apically expressed in epithelial cells, it facilitates transcellular transport (also called vectorial release), extracting PG from the apical medium and facilitating transport across the cell toward the basolateral side, whereupon the PG exits the cell by simple diffusion (PubMed:18579702). In the renal collecting duct, regulates renal Na+ balance by removing PGE2 from apical medium (PGE2 EP4 receptor is likely localized to the luminal/apical membrane and stimulates Na+ resorption) and transporting it toward the basolateral membrane (where PGE2 EP1 and EP3 receptors inhibit Na+ resorption) (PubMed:18579702). Plays a role in endometrium during decidualization, increasing uptake of PGs by decidual cells (By similarity). Involved in critical events for ovulation (PubMed:27169804). Regulates extracellular PGE2 concentration for follicular development in the ovaries (PubMed:27169804). When expressed intracellularly, such as in macrophages, contributes to vesicular uptake of newly synthesized intracellular PGs, thereby facilitating exocytotic secretion of PGs without being metabolized (PubMed:26474801). Essential core component of the major type of large-conductance anion channel, Maxi-Cl, which plays essential roles in inorganic anion transport, cell volume regulation and release of ATP and glutamate not only in physiological processes but also in pathological processes (PubMed:29046334, PubMed:32442363). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10., [RefSeq, PubMed]; Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1., [RefSeq, PubMed]; Prostaglandin (PG) transporter is expressed in active blastocysts and in glandular epithelium of the uterus during early pregnancy and may participate in PG signaling in mouse uterus during implantation and decidualization., [RefSeq, PubMed]; Prostaglandin transporter plays a critical role in closure of the ductus arteriosus after birth by ensuring a reduction in local and/or circulating PGE(2) concentrations., [RefSeq, PubMed]; Renal collecting duct prostaglandin transporter transcription varied with dietary salt intake., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015132 prostaglandin transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005764 lysosome;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0043252 sodium-independent organic anion transport;GO:0015732 prostaglandin transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9EPT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESX2-1", "uniprot_id": "SP6_MOUSE", "mass": 40016.0, "length": 376, "protein_name": "Transcription factor Sp6", "gene_name": "Sp6", "organism": "Mouse", "refseq_name": "transcription factor Sp6", "refseq_ac": "NP_112460", "gene_names_uniprotkb": "Sp6; Epfn; Klf14", "gene_names_refseq": "1110025J03Rik; Epfn; Klf14; Sp6", "protein_names_uniprotkb": "Transcription factor Sp6; Epiprofin; Krueppel-like factor 14", "protein_names_refseq": "Kruppel-like factor 14; Sp6 transcription factor; epiprofin; krueppel-like factor 14; specificity protein 6; transcription factor Sp6", "tax_id": 10090, "disease": "amelogenesis imperfecta type 1K (Disease Ontology:DOID:0060945); amelogenesis imperfecta (Disease Ontology:DOID:2187)", "pathway": " (mmu:83395)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11087666;14551215;30426815;33469169;34662808;35820727;40885482", "class_list": "", "function": "Epiprofin is a highly cell- and tissue-specific nuclear protein expressed primarily by proliferating epithelial cells of teeth, hair follicles, and limbs that may function in the development of these tissues by regulating cell growth, [RefSeq, PubMed]; Pannexin 3 regulates skin development via Epiprofin. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes cell proliferation (PubMed:14551215). Plays a role in tooth germ growth (PubMed:30426815). Plays a role in the control of enamel mineralization. Binds the AMBN promoter (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Sp6/Epiprofin is a master regulator in the developing tooth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6VM22", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0006366 transcription by RNA polymerase II;GO:0042476 odontogenesis;GO:0001837 epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9ESX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJG5-1", "uniprot_id": "SRTD2_MOUSE", "mass": 33312.0, "length": 309, "protein_name": "SERTA domain-containing protein 2", "gene_name": "Sertad2", "organism": "Mouse", "refseq_name": "SERTA domain-containing protein 2 isoform 1", "refseq_ac": "NP_001033714", "gene_names_uniprotkb": "Sertad2; Kiaa0127; MNCb-1504", "gene_names_refseq": "Kiaa0127; MNCb-1504; SEI-2; Sei2; Sertad2; TRIP-Br2; mKIAA0127", "protein_names_uniprotkb": "SERTA domain-containing protein 2; TRIP-Br2; Transcriptional regulator interacting with the PHD-bromodomain 2", "protein_names_refseq": "PHD zinc finger- and bromodomain-interacting protein 2; SERTA domain-containing protein 2 isoform 1; SERTA domain-containing protein 2; transcriptional regulator interacting with the PHD-bromodomain 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:58172)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11331592;23291629;27109496;28067333;29654510;34428180", "class_list": "", "function": "Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism., [UniProtKB, PubMed]; Data suggest that expression of microRNA-128-3p is down-regulated during adipogenesis; an abundance of microRNA-128-3p appears to down-regulate adipogenesis and up-regulate lipolysis in adipocytes by targeting expression of Pparg (peroxisome proliferator-activated receptor gamma) and Sertad2 (SERTA domain-containing protein-2)., [RefSeq, PubMed]; Study demonstrates a role for TRIP-Br2 in endoplasmic reticulum stress-induced brown adipose tissue (BAT) dysfunction, and inhibiting TRIP-Br2 could be a potential approach for counteracting obesity-induced BAT dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor GATA3 is responsible for the ER stress-induced TRIP-Br2 expression in visceral fat. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C609;Q91WL3;Q925E5", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1Z2-1", "uniprot_id": "STRAP_MOUSE", "mass": 38442.0, "length": 350, "protein_name": "Serine-threonine kinase receptor-associated protein", "gene_name": "Strap", "organism": "Mouse", "refseq_name": "serine-threonine kinase receptor-associated protein", "refseq_ac": "NP_035629", "gene_names_uniprotkb": "Strap; Unrip", "gene_names_refseq": "Strap; Unrip", "protein_names_uniprotkb": "Serine-threonine kinase receptor-associated protein; UNR-interacting protein", "protein_names_refseq": "UNR-interacting protein; serine-threonine kinase receptor-associated protein", "tax_id": 10090, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); adenocarcinoma (Disease Ontology:DOID:299); squamous cell neoplasm (Disease Ontology:DOID:3168); lung carcinoma (Disease Ontology:DOID:3905); large cell carcinoma (Disease Ontology:DOID:4552)", "pathway": " (mmu:20901); (R-MMU-2173788)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "17947660;25485581;25605945;30420355;31219806;33230114;34520730;35820727;37453647;39927985;9856985", "class_list": "", "function": "LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation., [RefSeq, PubMed]; STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Serine-threonine Kinase Receptor-Associated Protein is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a Feed-Forward Mechanism., [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BP89;Q8C6F6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005102 signaling receptor binding;GO:1990447 U2 snRNP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032797 SMN complex;GO:0034719 SMN-Sm protein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0030277 maintenance of gastrointestinal epithelium;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9Z1Z2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BG48-1", "uniprot_id": "ST17B_MOUSE", "mass": 41983.0, "length": 372, "protein_name": "Serine/threonine-protein kinase 17B", "gene_name": "Stk17b", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase 17B", "refseq_ac": "NP_598571", "gene_names_uniprotkb": "Stk17b; Drak2", "gene_names_refseq": "3110009A03Rik; Drak2; Stk17b", "protein_names_uniprotkb": "Serine/threonine-protein kinase 17B; 2.7.11.1; DAP kinase-related apoptosis-inducing protein kinase 2", "protein_names_refseq": "DAP kinase-related apoptosis-inducing protein kinase 2; serine/threonine-protein kinase 17B", "tax_id": 10090, "disease": "", "pathway": " (mmu:98267)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;15589167;16172133;16517594;17182616;20173027;21750661;25428506;25951457;31219806;34428180;34536317;34614409;36210013;36773294", "class_list": "", "function": "Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity)., [UniProtKB]; DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing., [RefSeq, PubMed]; DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell development., [RefSeq, PubMed]; DRAK2 kinase activity is regulated in a calcium-dependent manner and that Ser(12) phosphorylation is necessary for optimal suppression of T cell activation by this kinase, [RefSeq, PubMed]; DRAK2 transduces non-apoptotic signals during thymocyte differentiation., [RefSeq, PubMed]; Data provide insight into the role of Drak2 in autoimmune diseases by showing that Drak2 may not suppress TGF-beta signaling in T cells, and therefore may contribute to autoimmune disease via other molecular pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Drak2 expresses in the T cell compartment but is not T cell-specific; it plays critical roles in T cell apoptosis and memory T cell development, [RefSeq, PubMed]; Serine/threonine kinase 17b (STK17B) signalling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias., [RefSeq, PubMed]; T cells from Drak2(-/-) mice exhibited enhanced sensitivity to T cell receptor-mediated stimulation with a reduced requirement for costimulation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNG7;Q8BLV9;Q923E7", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0090543 Flemming body", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8BG48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07759-1", "uniprot_id": "SPA3K_MOUSE", "mass": 46880.0, "length": 418, "protein_name": "Serine protease inhibitor A3K", "gene_name": "Serpina3k", "organism": "Mouse", "refseq_name": "serine protease inhibitor A3K precursor", "refseq_ac": "NP_035588", "gene_names_uniprotkb": "Serpina3k; Mcm2; Spi2", "gene_names_refseq": "1300001I07Rik; D12Rp54; MMCM2; MMSpi2; RP54; Serpina3k; Spi-2; Spi2; contrapsin", "protein_names_uniprotkb": "Serine protease inhibitor A3K; Contrapsin; SPI-2; Serpin A3K", "protein_names_refseq": "serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3K; serine (or cysteine) proteinase inhibitor, clade A, member 3K; serine protease inhibitor 2; serine protease inhibitor A3K precursor; serine protease inhibitor A3K; serpin A3K", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); cystic fibrosis (Disease Ontology:DOID:1485); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); vasculitis (Disease Ontology:DOID:865)", "pathway": " (mmu:20714)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;11916263;12659817;15638460;16944957;17330941;2049065;20571061;21750661;21913724;2277027;30899004;31044023;32152506;34428180;36288343;37175519;37453647;37507081;39627609;39927985;6214866;6224776;6547997", "class_list": "", "function": "Contrapsin inhibits trypsin-like proteases., [UniProtKB, PubMed, PubMed]; SerpinA3K Deficiency Reduces Oxidative Stress in Acute Kidney Injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q62257;Q8VCH3;Q91W80;Q91X80", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0034097 response to cytokine;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P07759-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51557-1", "uniprot_id": "STAR_MOUSE", "mass": 31626.0, "length": 284, "protein_name": "Steroidogenic acute regulatory protein, mitochondrial", "gene_name": "Star", "organism": "Mouse", "refseq_name": "steroidogenic acute regulatory protein, mitochondrial precursor", "refseq_ac": "NP_035615", "gene_names_uniprotkb": "Star", "gene_names_refseq": "D8Ertd419e; Star; stARD1", "protein_names_uniprotkb": "Steroidogenic acute regulatory protein, mitochondrial; Luteinizing hormone-induced protein; START domain-containing protein 1; StARD1; StAR", "protein_names_refseq": "START domain-containing protein 1; luteinizing hormone-induced protein; steroidogenic acute regulatory protein, mitochondrial precursor; steroidogenic acute regulatory protein, mitochondrial", "tax_id": 10090, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); polycystic ovary syndrome (Disease Ontology:DOID:11612); hypothyroidism (Disease Ontology:DOID:1459); hypogonadism (Disease Ontology:DOID:1924); nephrosis (Disease Ontology:DOID:2527); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:20845); (R-MMU-196108); (R-MMU-9837999)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12486153;1797581;18197253;19007846;21750661;22427666;24850413;30084848;7588255;7961770", "class_list": "", "function": "Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Transporter that binds to and transport cholesterol through the intermembrane space of the mitochondrion., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543A5;Q924Y5;Q9D2G1", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix;GO:0043025 neuronal cell body;GO:0030061 mitochondrial crista", "go_biological_process": "GO:0070859 positive regulation of bile acid biosynthetic process;GO:0035457 cellular response to interferon-alpha;GO:0071378 cellular response to growth hormone stimulus;GO:0006629 lipid metabolic process;GO:0006699 bile acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P51557-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62252-1", "uniprot_id": "SP17_MOUSE", "mass": 17296.0, "length": 149, "protein_name": "Sperm surface protein Sp17", "gene_name": "Spa17", "organism": "Mouse", "refseq_name": "sperm surface protein Sp17", "refseq_ac": "NP_001311474", "gene_names_uniprotkb": "Spa17; Sp17", "gene_names_refseq": "Sp17; Spa17", "protein_names_uniprotkb": "Sperm surface protein Sp17; Sperm autoantigenic protein 17", "protein_names_refseq": "band 34; sperm protein 17; sperm surface protein Sp17", "tax_id": 10090, "disease": "Merkel cell carcinoma (Disease Ontology:DOID:3965)", "pathway": " (mmu:20686)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17971504;18492746;21750661;7578682", "class_list": "", "function": "MRBMY protein can bind to the testis and sperm-specific spa17 mRNA., [RefSeq, PubMed]; Spa17 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium;GO:0031514 motile cilium;GO:0009897 external side of plasma membrane;GO:0035686 sperm fibrous sheath", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62252-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R207-1", "uniprot_id": "SPTSA_MOUSE", "mass": 8452.0, "length": 71, "protein_name": "Serine palmitoyltransferase small subunit A", "gene_name": "Sptssa", "organism": "Mouse", "refseq_name": "serine palmitoyltransferase small subunit A", "refseq_ac": "NP_598815", "gene_names_uniprotkb": "Sptssa; Ssspta", "gene_names_refseq": "1110002B05Rik; Sptssa; Ssspta", "protein_names_uniprotkb": "Serine palmitoyltransferase small subunit A; Small subunit of serine palmitoyltransferase A; ssSPTa", "protein_names_refseq": "serine palmitoyltransferase small subunit A; small subunit of serine palmitoyltransferase A", "tax_id": 10090, "disease": "hereditary spastic paraplegia 90A (Disease Ontology:DOID:0070459); hereditary spastic paraplegia 90B (Disease Ontology:DOID:0070460)", "pathway": " (mmu:104725); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;25428506;30084848;33662400;34428180", "class_list": "", "function": "Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSA stimulates the catalytic activity and plays a role in substrate specificity, which depends upon the overall complex composition. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Independently of its action as a SPT component, may be involved in MBOAT7 localization to mitochondria-associated membranes, a membrane bridge between the endoplasmic reticulum and mitochondria, may hence affect MBOAT7-catalyzed incorporation of arachidonic acid into phosphatidylinositol., [UniProtKB, UniProtKB]; SSSPTA is essential for serine palmitoyltransferase function during development and hematopoiesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHT2", "ec_number_list": "", "go_molecular_function": "GO:0004758 serine C-palmitoyltransferase activity", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0046512 sphingosine biosynthetic process;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47758-1", "uniprot_id": "SRPRB_MOUSE", "mass": 29579.0, "length": 269, "protein_name": "Signal recognition particle receptor subunit beta", "gene_name": "Srprb", "organism": "Mouse", "refseq_name": "signal recognition particle receptor subunit beta", "refseq_ac": "NP_033301", "gene_names_uniprotkb": "Srprb", "gene_names_refseq": "Srprb", "protein_names_uniprotkb": "Signal recognition particle receptor subunit beta; SR-beta", "protein_names_refseq": "SR-beta; signal recognition particle receptor subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:20818)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "16439358;16675701;21750661;22645316;22872234;25428506;25605945;30084848;31219806;31599954;34428180;35820727;7844142", "class_list": "", "function": "Component of the SRP (signal recognition particle) receptor (PubMed:7844142). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:7844142). May mediate the membrane association of SR (PubMed:7844142)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544X9;Q9D872", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005785 signal recognition particle receptor complex;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005881 cytoplasmic microtubule;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045047 protein targeting to ER;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P47758-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGQ7-1", "uniprot_id": "SYAC_MOUSE", "mass": 106909.0, "length": 968, "protein_name": "Alanine--tRNA ligase, cytoplasmic", "gene_name": "Aars1", "organism": "Mouse", "refseq_name": "alanine--tRNA ligase, cytoplasmic", "refseq_ac": "NP_666329", "gene_names_uniprotkb": "Aars1; Aars", "gene_names_refseq": "Aars1; Aars; sti", "protein_names_uniprotkb": "Alanine--tRNA ligase, cytoplasmic; 6.-.-.-; 6.1.1.7; AlaRS; Alanyl-tRNA synthetase; Protein lactyltransferase AARS1; Protein sticky; Sti", "protein_names_refseq": "alaRS; alanine--tRNA ligase, cytoplasmic; alanyl-tRNA synthetase, cytoplasmic; protein lactyltransferase AARS1; protein sticky", "tax_id": 10090, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); nonphotosensitive trichothiodystrophy 8 (Disease Ontology:DOID:0061023); developmental and epileptic encephalopathy 29 (Disease Ontology:DOID:0080451); Charcot-Marie-Tooth disease axonal type 2N (Disease Ontology:DOID:0110177); dermatomyositis (Disease Ontology:DOID:10223); leukodystrophy (Disease Ontology:DOID:10579); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); microcephaly (Disease Ontology:DOID:10907); axonal neuropathy (Disease Ontology:DOID:7319)", "pathway": " (mmu:234734)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;16139798;16906134;20010690;21750661;22645316;24788674;25153642;25422440;25428506;27622773;29769718;30084848;30779550;31219806;32611769;33300544;34203471;34428180;35067747;37507081;39627609", "class_list": "", "function": "Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:16906134, PubMed:20010690, PubMed:25422440, PubMed:27622773). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:16906134, PubMed:20010690, PubMed:25422440, PubMed:29769718). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1. Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins. Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53. Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, PubMed, PubMed]; Defects in aminoacyl-tRNA synthetase cause partial B and T cell immunodeficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue., [RefSeq, PubMed]; The mouse sticky mutation, which causes cerebellar Purkinje cell loss and ataxia, is a missense mutation in the editing domain of the alanyl-tRNA synthetase gene that compromises the proofreading activity of this enzyme during aminoacylation of tRNAs, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXR0", "ec_number_list": "6.1.1.7;6.-.-.-", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016597 amino acid binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050885 neuromuscular process controlling balance;GO:0050905 neuromuscular process;GO:0035329 hippo signaling;GO:0006400 tRNA modification;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8BGQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BMA6-1", "uniprot_id": "SRP68_MOUSE", "mass": 70574.0, "length": 625, "protein_name": "Signal recognition particle subunit SRP68", "gene_name": "Srp68", "organism": "Mouse", "refseq_name": "signal recognition particle subunit SRP68", "refseq_ac": "NP_666144", "gene_names_uniprotkb": "Srp68", "gene_names_refseq": "2610024I03Rik; Srp68", "protein_names_uniprotkb": "Signal recognition particle subunit SRP68; SRP68; Signal recognition particle 68 kDa protein", "protein_names_refseq": "likely ortholog of H. sapiens signal recognition particle 68kDa (SRP68); signal recognition particle 68 kDa protein; signal recognition particle 68kDa; signal recognition particle subunit SRP68", "tax_id": 10090, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590)", "pathway": " (mmu:217337); (R-MMU-1799339)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;31219806;34428180;37453647;37828378", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AAN1;Q6NS76", "ec_number_list": "", "go_molecular_function": "GO:0005047 signal recognition particle binding;GO:0030942 endoplasmic reticulum signal peptide binding;GO:0019904 protein domain specific binding;GO:0043022 ribosome binding;GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005925 focal adhesion", "go_biological_process": "GO:0009410 response to xenobiotic stimulus;GO:0006614 SRP-dependent cotranslational protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BMA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97355-1", "uniprot_id": "SPSY_MOUSE", "mass": 41313.0, "length": 366, "protein_name": "Spermine synthase", "gene_name": "Sms", "organism": "Mouse", "refseq_name": "spermine synthase isoform 1", "refseq_ac": "NP_033240", "gene_names_uniprotkb": "Sms", "gene_names_refseq": "Gy; SPMSY; Sms; SpmST; gyro", "protein_names_uniprotkb": "Spermine synthase; 2.5.1.22; SPMSY; Spermidine aminopropyltransferase", "protein_names_refseq": "spermidine aminopropyltransferase; spermine synthase isoform 1", "tax_id": 10090, "disease": "syndromic X-linked intellectual disability Snyder type (Disease Ontology:DOID:0060802); anxiety disorder (Disease Ontology:DOID:2030)", "pathway": " (mmu:20603); (R-MMU-351202)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;11160858;15459188;21750661;30059200;39927985;9063736;9467015", "class_list": "", "function": "Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM) (PubMed:9467015). Required for normal viability, growth and fertility (PubMed:15459188)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AC82;Q3TL65;Q3TUP0;Q3UDT8;Q8C7P4;Q9CT09;Q9R282", "ec_number_list": "2.5.1.22", "go_molecular_function": "GO:0016768 spermine synthase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006597 spermine biosynthetic process;GO:0008215 spermine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P97355-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16254-1", "uniprot_id": "SRP14_MOUSE", "mass": 12510.0, "length": 110, "protein_name": "Signal recognition particle 14 kDa protein", "gene_name": "Srp14", "organism": "Mouse", "refseq_name": "signal recognition particle 14 kDa protein", "refseq_ac": "NP_033299", "gene_names_uniprotkb": "Srp14", "gene_names_refseq": "14kDa; Srp14", "protein_names_uniprotkb": "Signal recognition particle 14 kDa protein; SRP14", "protein_names_refseq": "(homologous Alu RNA binding protein); homologous Alu RNA-binding protein; signal recognition particle 14 kDa protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20813); (R-MMU-1799339); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "17242355;21183079;21750661;2557625;26740625;31219806;33725478;34428180;37453647;9233785", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIK2", "ec_number_list": "", "go_molecular_function": "GO:0030942 endoplasmic reticulum signal peptide binding;GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0045047 protein targeting to ER", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P16254-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2RSX4-1", "uniprot_id": "STPG3_MOUSE", "mass": 34690.0, "length": 306, "protein_name": "Protein STPG3", "gene_name": "Stpg3", "organism": "Mouse", "refseq_name": "protein STPG3", "refseq_ac": "NP_083237", "gene_names_uniprotkb": "Stpg3", "gene_names_refseq": "4933433C11Rik; Stpg3", "protein_names_uniprotkb": "Protein STPG3; Sperm-tail PG-rich repeat-containing protein 3", "protein_names_refseq": "protein STPG3; sperm-tail PG-rich repeat-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:74472)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "33300544", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2RSX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3T5-1", "uniprot_id": "STXB6_MOUSE", "mass": 23671.0, "length": 210, "protein_name": "Syntaxin-binding protein 6", "gene_name": "Stxbp6", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Stxbp6", "gene_names_refseq": "", "protein_names_uniprotkb": "Syntaxin-binding protein 6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0035542 regulation of SNARE complex assembly;GO:0035493 SNARE complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R3T5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49962-1", "uniprot_id": "SRP09_MOUSE", "mass": 10194.0, "length": 86, "protein_name": "Signal recognition particle 9 kDa protein", "gene_name": "Srp9", "organism": "Mouse", "refseq_name": "signal recognition particle 9 kDa protein", "refseq_ac": "NP_036188", "gene_names_uniprotkb": "Srp9", "gene_names_refseq": "9kDa; Srp9", "protein_names_uniprotkb": "Signal recognition particle 9 kDa protein; SRP9", "protein_names_refseq": "signal recognition particle 9 kDa protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:27058); (R-MMU-1799339)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21750661;30084848;31219806;34428180;36210013;7518078;9233785", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D085", "ec_number_list": "", "go_molecular_function": "GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005829 cytosol", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0045900 negative regulation of translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P49962-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CDJ8-1", "uniprot_id": "STON1_MOUSE", "mass": 81793.0, "length": 730, "protein_name": "Stonin-1", "gene_name": "Ston1", "organism": "Mouse", "refseq_name": "stonin-1", "refseq_ac": "NP_084134", "gene_names_uniprotkb": "Ston1; Salf; Sblf; Stn1", "gene_names_refseq": "4921524J06Rik; Salf; Sblf; Ston1", "protein_names_uniprotkb": "Stonin-1; Stoned B-like factor", "protein_names_refseq": "stoned B-like factor; stoned B/TFIIA-alpha/beta-like factor; stonin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:77057); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;26437238;28135057;30084848;30779550;34428180;35820727", "class_list": "", "function": "Data establish Stonin1 as a specific adaptor for the endocytosis of NG2 and as an important factor for focal adhesion dynamics and cell migration. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in the endocytic machinery., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDL8;Q9D5T3", "ec_number_list": "", "go_molecular_function": "GO:0035615 clathrin adaptor activity;GO:0140312 cargo adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005905 clathrin-coated pit;GO:0031252 cell leading edge;GO:0030122 AP-2 adaptor complex;GO:0042995 cell projection", "go_biological_process": "GO:0006897 endocytosis;GO:0030100 regulation of endocytosis;GO:0048041 focal adhesion assembly;GO:0006929 substrate-dependent cell migration;GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CDJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZV5-1", "uniprot_id": "ST65G_MOUSE", "mass": 45971.0, "length": 412, "protein_name": "STAGA complex 65 subunit gamma", "gene_name": "Supt7l", "organism": "Mouse", "refseq_name": "STAGA complex 65 subunit gamma", "refseq_ac": "NP_082426", "gene_names_uniprotkb": "Supt7l", "gene_names_refseq": "2610524B01Rik; 6030455L14Rik; Supt7l", "protein_names_uniprotkb": "STAGA complex 65 subunit gamma; SPTF-associated factor 65 gamma; STAF65gamma; Suppressor of Ty 7-like", "protein_names_refseq": "SPTF-associated factor 65 gamma; STAF65gamma; STAGA complex 65 subunit gamma; suppressor of Ty 7-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:72195)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21183079;21750661;25428506;31219806;34428180;36210013", "class_list": "", "function": "As a component of the STAGA transcription coactivator-HAT complex, is involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000124 SAGA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0043484 regulation of RNA splicing;GO:0051457 maintenance of protein location in nucleus;GO:0006282 regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CZV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5I2A0-1", "uniprot_id": "SPA3G_MOUSE", "mass": 49021.0, "length": 440, "protein_name": "Serine protease inhibitor A3G", "gene_name": "Serpina3g", "organism": "Mouse", "refseq_name": "serine protease inhibitor A3G isoform 1", "refseq_ac": "NP_033277", "gene_names_uniprotkb": "Serpina3g; Spi2A", "gene_names_refseq": "2A2; Serpina3g; Spi2-1; Spi2/eb.1; Spi2A; spi2", "protein_names_uniprotkb": "Serine protease inhibitor A3G; Serine protease inhibitor 2A; Serpin 2A; Serpin A3G", "protein_names_refseq": "alpha-1 antiproteinase; serine (or cysteine) proteinase inhibitor, clade A, member 3G; serine protease inhibitor 2-1; serine protease inhibitor 2A; serine protease inhibitor A3G isoform 1; serine protease inhibitor A3G; serpin 2A; serpin A3G", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); cystic fibrosis (Disease Ontology:DOID:1485); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); vasculitis (Disease Ontology:DOID:865)", "pathway": " (mmu:20715)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;11438738;12470299;12659817;14517268;15225607;15311278;15638460;21750661;24964278;24973688;26495903;29106998;34428180;8978283", "class_list": "", "function": "Authors define roles for an HP-regulated Serpina3g/Spi2A intracellular serpin during granulomyelocytic, B-cell, and hematopoietic stem cell (HSC) formation., [RefSeq, PubMed]; Serine and cysteine protease inhibitor. Can inhibit lysosomal papain-like proteases including the cathepsins B, G, H, K, L and V. Ineffective against elastase, granzyme A, granzyme B, or caspases 3, 8 or 9. Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis. This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells., [UniProtKB, PubMed, PubMed, PubMed]; SerpinA3g plays a role in the TNF-alpha modulation of adipose tissue development and metabolism., [RefSeq, PubMed]; This study shows that Spi2a contributes to survival of allergenic TH2 cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PG99", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0002250 adaptive immune response;GO:0034097 response to cytokine;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q5I2A0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62147-1", "uniprot_id": "SSPN_MOUSE", "mass": 23859.0, "length": 216, "protein_name": "Sarcospan", "gene_name": "Sspn", "organism": "Mouse", "refseq_name": "sarcospan isoform 1", "refseq_ac": "NP_034786", "gene_names_uniprotkb": "Sspn; Krag", "gene_names_refseq": "Gm32675; Krag; Sspn", "protein_names_uniprotkb": "Sarcospan; K-ras oncogene-associated protein; Kirsten-Ras-associated protein", "protein_names_refseq": "K-ras oncogene-associated protein; Kras oncogene-associated; kirsten-Ras-associated protein; sarcospan isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16651); (R-MMU-9913351)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;27798107;28587652;33432327;37511627;8020969", "class_list": "", "function": "An alternatively spliced isoform of sarcospan localizes to the sarcoplasmic reticulum in skeletal muscle. It is absent in Sgcd-/- skeletal muscle, a murine model for limb girdle muscular dystrophy 2F. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC (By similarity)., [UniProtKB]; Loss of sarcospan exacerbates pathology in mdx mice, but does not affect utrophin amelioration of disease., [RefSeq, PubMed]; Sarcospan Deficiency Increases Oxidative Stress and Arrhythmias in Hearts after Acute Ischemia-Reperfusion Injury. Publication Status: Online-Only, [RefSeq, PubMed]; These results demonstrate that SSPN overexpression is well tolerated in mdx mice and improves sarcolemma defects that underlie skeletal muscle and pulmonary dysfunction in Duchenne muscular dystrophy, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60594", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0030133 transport vesicle;GO:0042383 sarcolemma", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62147-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30933-1", "uniprot_id": "SVS5_MOUSE", "mass": 13019.0, "length": 122, "protein_name": "Seminal vesicle secretory protein 5", "gene_name": "Svs5", "organism": "Mouse", "refseq_name": "seminal vesicle secretory protein 5 precursor", "refseq_ac": "NP_033327", "gene_names_uniprotkb": "Svs5; Svp5", "gene_names_refseq": "Semg1; Svp-1; Svp1; Svp5; Svs5", "protein_names_uniprotkb": "Seminal vesicle secretory protein 5; SVS V; SVS protein F; Seminal vesicle secretory protein V", "protein_names_refseq": "SVS V; SVS protein F; semenogelin I; seminal vesicle protein 1; seminal vesicle protein F; seminal vesicle secretion 5; seminal vesicle secretory protein 5 precursor; seminal vesicle secretory protein V", "tax_id": 10090, "disease": "", "pathway": " (mmu:20944)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P30933-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VIM6-1", "uniprot_id": "STRC_MOUSE", "mass": 196347.0, "length": 1809, "protein_name": "Stereocilin", "gene_name": "Strc", "organism": "Mouse", "refseq_name": "stereocilin precursor", "refseq_ac": "NP_536707", "gene_names_uniprotkb": "Strc", "gene_names_refseq": "DFNB16; Strc", "protein_names_uniprotkb": "Stereocilin", "protein_names_refseq": "stereocilin precursor", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 16 (Disease Ontology:DOID:0110471); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (mmu:140476)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11687802;18849963;21165971;21750661;30084848;31776257", "class_list": "", "function": "Essential to the formation of horizontal top connectors between outer hair cell stereocilia., [UniProtKB, PubMed]; Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane., [RefSeq, PubMed]; Stereocilin was detected in association with horizontal top connectors, lateral links that join adjacent stereocilia within the outer hair cell's hair bundle, [RefSeq, PubMed]", "predicted_glycosites": 19, "predicted_n_glycosites": 15, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "A2ARP7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0009986 cell surface;GO:0060091 kinocilium;GO:0032426 stereocilium tip", "go_biological_process": "GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0007160 cell-matrix adhesion;GO:0007605 sensory perception of sound;GO:0008104 intracellular protein localization;GO:0060088 auditory receptor cell stereocilium organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VIM6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O08858-1", "uniprot_id": "SSR5_MOUSE", "mass": 40008.0, "length": 362, "protein_name": "Somatostatin receptor type 5", "gene_name": "Sstr5", "organism": "Mouse", "refseq_name": "somatostatin receptor type 5", "refseq_ac": "NP_001177937", "gene_names_uniprotkb": "Sstr5; Smstr5", "gene_names_refseq": "Smstr5; Sstr5; sst5", "protein_names_uniprotkb": "Somatostatin receptor type 5; SS-5-R; SS5-R; SS5R", "protein_names_refseq": "SS-5-R; SS5-R; SS5R; somatostatin receptor type 5", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); bipolar disorder (Disease Ontology:DOID:3312)", "pathway": " (mmu:20609); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;21820437;33428965;33434183;34224803;35680973;9300821", "class_list": "", "function": "Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; Filamin A is required for somatostatin receptor type 5 expression and pasireotide-mediated signaling in pituitary corticotroph tumor cells., [RefSeq, PubMed]; Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization., [UniProtKB]; Somatostatin receptor 5 is critical for protecting intestinal barrier function in vivo and in vitro., [RefSeq, PubMed]; TRPV1(+) sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A6H6N8;O08998;Q3UZM7", "ec_number_list": "", "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion;GO:0071385 cellular response to glucocorticoid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O08858-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09116-1", "uniprot_id": "SPRR3_MOUSE", "mass": 25241.0, "length": 238, "protein_name": "Small proline-rich protein 3", "gene_name": "Sprr3", "organism": "Mouse", "refseq_name": "small proline-rich protein 3", "refseq_ac": "NP_001191356", "gene_names_uniprotkb": "Sprr3", "gene_names_refseq": "SPR3; Sprr3", "protein_names_uniprotkb": "Small proline-rich protein 3; Cornifin beta", "protein_names_refseq": "cornifin beta; small proline-rich protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:20766); (R-MMU-6809371)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25278290;9724607", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes., [UniProtKB]; SPRR3 protects an atheroma lesion from vascular smooth muscle cell (VSMC) loss by promoting survival signaling in plaque VSMCs, thereby significantly decreasing atherosclerosis progression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q059J8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0031424 keratinization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O09116-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55183-1", "uniprot_id": "STC1_MOUSE", "mass": 27480.0, "length": 247, "protein_name": "Stanniocalcin-1", "gene_name": "Stc1", "organism": "Mouse", "refseq_name": "stanniocalcin-1 precursor", "refseq_ac": "NP_033311", "gene_names_uniprotkb": "Stc1; Stc", "gene_names_refseq": "Stc1; Stc", "protein_names_uniprotkb": "Stanniocalcin-1; STC-1", "protein_names_refseq": "STC-1; stanniocalcin-1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:20855)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22872234;34268656;35042959;35122667;9027337", "class_list": "", "function": "STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts., [RefSeq, PubMed]; Stanniocalcin 1 is a serum biomarker and potential therapeutic target for HBV-associated liver fibrosis., [RefSeq, PubMed]; Stanniocalcin-1 Protected Astrocytes from Hypoxic Damage Through the AMPK Pathway., [RefSeq, PubMed]; Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0006874 intracellular calcium ion homeostasis;GO:0030336 negative regulation of cell migration;GO:0071456 cellular response to hypoxia;GO:0051926 negative regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O55183-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18419-1", "uniprot_id": "SVS4_MOUSE", "mass": 12515.0, "length": 113, "protein_name": "Seminal vesicle secretory protein 4", "gene_name": "Svs4", "organism": "Mouse", "refseq_name": "seminal vesicle secretory protein 4 precursor", "refseq_ac": "NP_033326", "gene_names_uniprotkb": "Svs4; Svp2", "gene_names_refseq": "SVS-IV; Svp-2; Svp-4; Svp2; Svp4; Svs4", "protein_names_uniprotkb": "Seminal vesicle secretory protein 4; SVS IV; Seminal vesicle protein 2; Seminal vesicle secretory protein IV", "protein_names_refseq": "SVS IV; seminal vesicle protein 2; seminal vesicle protein 4; seminal vesicle secretory protein 4 precursor; seminal vesicle secretory protein IV", "tax_id": 10090, "disease": "", "pathway": " (mmu:20941)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2484712;31044023", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A4C3;Q14BU4;Q9D257", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P18419-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29621-1", "uniprot_id": "SPA3C_MOUSE", "mass": 46766.0, "length": 417, "protein_name": "Serine protease inhibitor A3C", "gene_name": "Serpina3c", "organism": "Mouse", "refseq_name": "serine protease inhibitor A3C precursor", "refseq_ac": "NP_032484", "gene_names_uniprotkb": "Serpina3c; Klkbp", "gene_names_refseq": "1A1; Kalbp; Klkbp; Serpina3c; spi2", "protein_names_uniprotkb": "Serine protease inhibitor A3C; KBP; Kallikrein-binding protein; Serpin A3C", "protein_names_refseq": "KBP; kallikrein-binding protein; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3C; serine (or cysteine) proteinase inhibitor, clade A, member 3C; serine protease inhibitor A3C precursor; serine protease inhibitor A3C; serpin A3C", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); cystic fibrosis (Disease Ontology:DOID:1485); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); vasculitis (Disease Ontology:DOID:865)", "pathway": " (mmu:16625)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12659817;15638460;1756173;23386199;30084848;35263629;35429042;35436587", "class_list": "", "function": "SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway., [RefSeq, PubMed]; Serpina3c deficiency induced necroptosis promotes non-alcoholic fatty liver disease through beta-catenin/Foxo1/TLR4 signaling., [RefSeq, PubMed]; Serpina3c regulates adipose differentiation via the Wnt/beta-catenin-PPARgamma pathway., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0034097 response to cytokine;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P29621-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30875-1", "uniprot_id": "SSR2_MOUSE", "mass": 41222.0, "length": 369, "protein_name": "Somatostatin receptor type 2", "gene_name": "Sstr2", "organism": "Mouse", "refseq_name": "somatostatin receptor type 2 isoform A", "refseq_ac": "NP_001036071", "gene_names_uniprotkb": "Sstr2; Smstr2; Sst2", "gene_names_refseq": "SRIF-1; SS2R; SSTR-2; Smstr-2; Smstr2; Sstr2; sst2", "protein_names_uniprotkb": "Somatostatin receptor type 2; SRIF-1; SS-2-R; SS2-R; SS2R", "protein_names_refseq": "somatostatin receptor type 2 isoform A; somatostatin receptor type 2", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:20606); (R-MMU-375276); (R-MMU-418594)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11278805;1346068;1397330;16917505;25428506;7913111;8104154;9507021", "class_list": "", "function": "Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization., [UniProtKB, PubMed, PubMed]; The protein encoded by this gene is a receptor for somatostatin, which acts at many sites to inhibit the release of several hormones and other secretory proteins. The encoded protein is a member of the superfamily of receptors having seven transmembrane segments and is involved in many processes, including adenylyl cyclase inhibition, phosphotyrosine phosphatase stimulation, and inhibition of calcium entry and cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "P30934;Q91Y73", "ec_number_list": "", "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0030165 PDZ domain binding;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0030432 peristalsis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0071392 cellular response to estradiol stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P30875-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30935-1", "uniprot_id": "SSR3_MOUSE", "mass": 47216.0, "length": 428, "protein_name": "Somatostatin receptor type 3", "gene_name": "Sstr3", "organism": "Mouse", "refseq_name": "somatostatin receptor type 3", "refseq_ac": "NP_033244", "gene_names_uniprotkb": "Sstr3; Smstr3", "gene_names_refseq": "Smstr-3; Smstr3; Sstr3; sst3", "protein_names_uniprotkb": "Somatostatin receptor type 3; SS-3-R; SS3-R; SS3R; SSR-28", "protein_names_refseq": "SS-3-R; SS3-R; SS3R; SSR-28; somatostatin receptor type 3", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:20607); (R-MMU-375276); (R-MMU-418594); (R-MMU-5620922)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1328199;21750661;33185668;33372037;37660302", "class_list": "", "function": "Beta cell primary cilia mediate somatostatin responsiveness via SSTR3., [RefSeq, PubMed]; HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase., [UniProtKB, PubMed]; Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0VB04;Q3UVV5", "ec_number_list": "", "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0043005 neuron projection;GO:0097730 non-motile cilium;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P30935-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50236-1", "uniprot_id": "ST2A2_MOUSE", "mass": 33329.0, "length": 285, "protein_name": "Sulfotransferase 2A2", "gene_name": "Sult2a2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Sult2a2; Sta2; Sth2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sulfotransferase 2A2; 2.8.2.2; Hydroxysteroid sulfotransferase; ST2A2; ST", "protein_names_refseq": "", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (R-MMU-156584); (R-MMU-9753281)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8033251", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a potential wide variety of acceptor molecules bearing a hydroxyl group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05A88", "ec_number_list": "2.8.2.-;2.8.2.14;2.8.2.2;2.8.2.n2;2.8.2.4;2.8.2.1", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0004027 alcohol sulfotransferase activity;GO:0047704 bile-salt sulfotransferase activity;GO:0050294 steroid sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0008203 cholesterol metabolic process;GO:0006068 ethanol catabolic process;GO:0006805 xenobiotic metabolic process;GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P50236-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52843-1", "uniprot_id": "ST2A1_MOUSE", "mass": 33213.0, "length": 285, "protein_name": "Sulfotransferase 2A1", "gene_name": "Sult2a1", "organism": "Mouse", "refseq_name": "sulfotransferase 2A1", "refseq_ac": "NP_001104766", "gene_names_uniprotkb": "Sult2a1; Sta1", "gene_names_refseq": "ST2A1; Std; Sth1; Sult2a1; mSTa1", "protein_names_uniprotkb": "Sulfotransferase 2A1; 2.8.2.14; 2.8.2.2; Bile salt sulfotransferase 1; Hydroxysteroid sulfotransferase; ST2A1; ST", "protein_names_refseq": "ST; bile salt sulfotransferase 1; hydroxysteroid sulfotransferase; sulfotransferase 2A1; sulfotransferase, DHEA preferring; sulfotransferase, hydroxysteroid preferring 1", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:20859)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12639899;23674610;37453647;8483851", "class_list": "", "function": "During embryonic development, SULT2B1a produces pregnenolone sulfate, an essential neurosteroid during development of the central nervous system., [RefSeq, PubMed]; Hyposulfatemia leads to hepatic phosphoadenosine-5'-phosphosulfate depletion, which causes loss of SULT2A1 activity and results in accumulation of nonsulfated bile acids and activated farnesoid X receptor activation., [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:12639899). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism (By similarity). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-;2.8.2.14;2.8.2.2;2.8.2.4", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0004027 alcohol sulfotransferase activity;GO:0047704 bile-salt sulfotransferase activity;GO:0050294 steroid sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0008203 cholesterol metabolic process;GO:0006068 ethanol catabolic process;GO:0006805 xenobiotic metabolic process;GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P52843-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63046-1", "uniprot_id": "ST4A1_MOUSE", "mass": 33054.0, "length": 284, "protein_name": "Sulfotransferase 4A1", "gene_name": "Sult4a1", "organism": "Mouse", "refseq_name": "sulfotransferase 4A1 isoform 1", "refseq_ac": "NP_038901", "gene_names_uniprotkb": "Sult4a1; Sultx3", "gene_names_refseq": "2400007A17Rik; BR-STL-1; BR-STL; NST; ST4A1; Sult4a1; Sultx3; mBR-STL", "protein_names_uniprotkb": "Sulfotransferase 4A1; 2.8.2.-; Brain sulfotransferase-like protein; NST; Nervous system sulfotransferase; ST4A1; mBR-STL", "protein_names_refseq": "brain sulfotransferase-like protein; nervous system sulfotransferase; sulfotransferase 4A1 isoform 1; sulfotransferase 4A1; sulfotransferase-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:29859); (R-MMU-156584)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12039030;25428506;30606728;31266751;32801157", "class_list": "", "function": "Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS., [UniProtKB, PubMed]; SULT4A1 Modulates Synaptic Development and Function by Promoting the Formation of PSD-95/NMDAR Complex., [RefSeq, PubMed]; Study in SULT4A1 knockout mice demonstrates that depletion of SULT4A1 induces oxidative stress in neurons and expression of SULT4A1 in human SH-SY5Y cells protects against oxidative-stress-induced mitochondrial dysfunction and cell death. Results suggest that SULT4A1 may have a crucial protective function against mitochondrial dysfunction and oxidative stress., [RefSeq, PubMed]; Study using SH-SY5Y cells, human induced pluripotent stem cells, and mouse embryonic tissue revealed time-dependent changes in SULT4A1 protein and MBNL/CELF protein during differentiation supported their role in correctly splicing the SULT4A1 mRNA. Furthermore, ectopic expression of each factor produced efficient splicing in the minigene assay as well as correct splicing of the endogenous SULT4A1 mRNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88872;Q3TXY5;Q91XS5;Q9CWY7;Q9DC97", "ec_number_list": "2.8.2.-;2.8.2.n2;2.8.2.4;2.8.2.2;2.8.2.1", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0140059 dendrite arborization;GO:0008202 steroid metabolic process;GO:0006790 sulfur compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P63046-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14CH7-1", "uniprot_id": "SYAM_MOUSE", "mass": 106783.0, "length": 980, "protein_name": "Alanine--tRNA ligase, mitochondrial", "gene_name": "Aars2", "organism": "Mouse", "refseq_name": "alanine--tRNA ligase, mitochondrial isoform 1 precursor", "refseq_ac": "NP_941010", "gene_names_uniprotkb": "Aars2; Aarsl; Gm89; Kiaa1270", "gene_names_refseq": "Aars2; Aarsl; AlaRS; Gm89", "protein_names_uniprotkb": "Alanine--tRNA ligase, mitochondrial; 6.-.-.-; 6.1.1.7; AlaRS; Alanyl-tRNA synthetase; Protein lactyltransferase AARS2", "protein_names_refseq": "alanine--tRNA ligase, mitochondrial isoform 1 precursor; alanine--tRNA ligase, mitochondrial; alanyl-tRNA synthetase, mitochondrial; protein lactyltransferase AARS2", "tax_id": 10090, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); progressive leukoencephalopathy with ovarian failure (Disease Ontology:DOID:0070396); combined oxidative phosphorylation deficiency 8 (Disease Ontology:DOID:0111479); dermatomyositis (Disease Ontology:DOID:10223); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); microcephaly (Disease Ontology:DOID:10907); axonal neuropathy (Disease Ontology:DOID:7319)", "pathway": " (mmu:224805)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29228266;39322678", "class_list": "", "function": "Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS (PubMed:39322678). Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:39322678)., [UniProtKB, HAMAP, PubMed]; Editing-deficient mitochondrial alanyl-tRNA synthetase (mtAlaRS) mice, bearing either a mild or a severe mtAlaRS editing mutation, and indicate that editing of mischarged tRNAs by alanyl-tRNA synthetase is an essential protein quality control mechanism in mammalian mitochondria., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q68FH3;Q69ZM9", "ec_number_list": "6.1.1.7;6.-.-.-", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0004813 alanine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0070143 mitochondrial alanyl-tRNA aminoacylation;GO:0160049 negative regulation of cGAS/STING signaling pathway;GO:0140896 cGAS/STING signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q14CH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UN54-1", "uniprot_id": "PAT14_MOUSE", "mass": 11155.0, "length": 99, "protein_name": "Prostate and testis expressed protein 14", "gene_name": "Pate14", "organism": "Mouse", "refseq_name": "prostate and testis expressed protein 14 precursor", "refseq_ac": "NP_001028497", "gene_names_uniprotkb": "Pate14; A630095E13Rik; Sslp1", "gene_names_refseq": "A630095E13Rik; Gm191; Pate14; Sslp-1; Sslp1", "protein_names_uniprotkb": "Prostate and testis expressed protein 14; SSLP-1; Secreted seminal-vesicle Ly-6 protein 1", "protein_names_refseq": "prostate and testis expressed protein 14 precursor; prostate and testis expressed protein 14; secreted seminal-vesicle Ly-6 protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:235973)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16940290;21750661;21942998;27098205", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9630, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3UN54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5IBH6-1", "uniprot_id": "SPE4A_MOUSE", "mass": 30977.0, "length": 268, "protein_name": "Speedy protein E4A", "gene_name": "Spdye4a", "organism": "Mouse", "refseq_name": "speedy protein E4A isoform 1", "refseq_ac": "NP_083324", "gene_names_uniprotkb": "Spdye4a; Spdyb", "gene_names_refseq": "4930445A17Rik; 4930451F05Rik; RINGO E4A; Spdy2; Spdyb; Spdye4a; Spdye4; Spy/Ringo B", "protein_names_uniprotkb": "Speedy protein E4A; RINGO E4A; Rapid inducer of G2/M progression in oocytes E4A; mSpy/Ringo E4A", "protein_names_refseq": "mSpy/Ringo B; mSpy/Ringo E4A; rapid inducer of G2/M progression in oocytes B; rapid inducer of G2/M progression in oocytes E4A; speedy homolog 2; speedy homolog E4; speedy protein B; speedy protein E4A isoform 1; speedy protein E4A", "tax_id": 10090, "disease": "", "pathway": " (mmu:74673)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15611625;21750661;36272447", "class_list": "", "function": "Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene., [RefSeq, PubMed]; Promotes progression through the cell cycle via binding and activation of CDK1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5IBH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SV06-1", "uniprot_id": "SPT22_MOUSE", "mass": 40163.0, "length": 358, "protein_name": "Spermatogenesis-associated protein 22", "gene_name": "Spata22", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 22", "refseq_ac": "NP_001038996", "gene_names_uniprotkb": "Spata22; Gm882; Repro42", "gene_names_refseq": "Gm882; Spata22", "protein_names_uniprotkb": "Spermatogenesis-associated protein 22", "protein_names_refseq": "spermatogenesis-associated protein 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:380709)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22011390;24240703;30272023;30746471;32345962", "class_list": "", "function": "Meiosis-specific protein required for homologous recombination in meiosis I., [UniProtKB, PubMed]; Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005694 chromosome", "go_biological_process": "GO:0009566 fertilization;GO:0051445 regulation of meiotic cell cycle;GO:0007129 homologous chromosome pairing at meiosis;GO:0000711 meiotic DNA repair synthesis;GO:0061458 reproductive system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5SV06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62280-1", "uniprot_id": "SSXT_MOUSE", "mass": 45864.0, "length": 418, "protein_name": "Protein SSXT", "gene_name": "Ss18", "organism": "Mouse", "refseq_name": "protein SSXT isoform 1", "refseq_ac": "NP_033306", "gene_names_uniprotkb": "Ss18; Ssxt; Syt", "gene_names_refseq": "D130059H17; Ss18; Ssxt; Syt", "protein_names_uniprotkb": "Protein SSXT; Protein SYT; Synovial sarcoma-associated Ss18-alpha", "protein_names_refseq": "SS18, nBAF chromatin remodeling complex subunit; protein SSXT isoform 1; protein SSXT; synovial sarcoma associated SS18-beta; synovial sarcoma associated SS18-delta; synovial sarcoma associated SS18-gamma; synovial sarcoma translocation, Chromosome 18; synovial sarcoma, translocated to X chromosome; synovial sarcoma-associated Ss18-alpha", "tax_id": 10090, "disease": "synovial sarcoma (Disease Ontology:DOID:5485)", "pathway": " (mmu:268996); (R-MMU-9933937); (R-MMU-9933946); (R-MMU-9933947); (R-MMU-9934037)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "11435705;21750661;25428506;29374058;30084848;34215745;34428180;40997131;8760306", "class_list": "", "function": "Appears to function synergistically with RBM14 as a transcriptional coactivator. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner., [UniProtKB, UniProtKB]; SS18 regulates pluripotent-somatic transition through phase separation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TM96", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62280-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64674-1", "uniprot_id": "SPEE_MOUSE", "mass": 33995.0, "length": 302, "protein_name": "Spermidine synthase", "gene_name": "Srm", "organism": "Mouse", "refseq_name": "spermidine synthase", "refseq_ac": "NP_033298", "gene_names_uniprotkb": "Srm", "gene_names_refseq": "SpdST; SpdSy; Srm", "protein_names_uniprotkb": "Spermidine synthase; 2.5.1.16; Putrescine aminopropyltransferase; SPDSY", "protein_names_refseq": "putrescine aminopropyltransferase; spermidine synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:20810); (R-MMU-351202)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21809077;31219806;33811915;34203471;34428180;7803821", "class_list": "", "function": "Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine (By similarity)., [UniProtKB]; ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration., [RefSeq, PubMed]; Results indicate that SpdS levels are not rate limiting in vivo for polyamine biosynthesis and are unlikely to exert significant regulatory effects on cellular polyamine content and function, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.16", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0004766 spermidine synthase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006597 spermine biosynthetic process;GO:0008295 spermidine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64674-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64704-1", "uniprot_id": "STX3_MOUSE", "mass": 33243.0, "length": 289, "protein_name": "Syntaxin-3", "gene_name": "Stx3", "organism": "Mouse", "refseq_name": "syntaxin-3 isoform B", "refseq_ac": "NP_001020478", "gene_names_uniprotkb": "Stx3; Stx3a", "gene_names_refseq": "Stx3; Syn-3", "protein_names_uniprotkb": "Syntaxin-3", "protein_names_refseq": "syntaxin-3 isoform B", "tax_id": 10090, "disease": "congenital diarrhea (Disease Ontology:DOID:0060774)", "pathway": " (mmu:20908); (R-MMU-449836)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;26406599;28369466;32778589;33192329;33974130;37114883;7598732", "class_list": "", "function": "Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles (By similarity). Essential for survival of retinal photoreceetors (PubMed:33974130)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Syntaxin 3 SPI-2 dependent crosstalk facilitates the division of Salmonella containing vacuole., [RefSeq, PubMed]; Syntaxin 3 is essential for photoreceptor outer segment protein trafficking and survival., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBP0;Q8R1B7", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding;GO:0050544 arachidonate binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0008284 positive regulation of cell population proliferation;GO:0031175 neuron projection development;GO:0045785 positive regulation of cell adhesion;GO:2000010 positive regulation of protein localization to cell surface", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q64704-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P926-1", "uniprot_id": "SPA24_MOUSE", "mass": 23769.0, "length": 205, "protein_name": "Spermatogenesis-associated protein 24", "gene_name": "Spata24", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 24 isoform 1", "refseq_ac": "NP_082009", "gene_names_uniprotkb": "Spata24; Tipt2; Tipt", "gene_names_refseq": "2700012K08Rik; 4930583E11Rik; 5133400G04Rik; Spata24; TIPT2; TIPT", "protein_names_uniprotkb": "Spermatogenesis-associated protein 24; TATA-binding protein-like factor-interacting protein; TLF-interacting protein; TRF2-interacting protein in testis; Testis protein T6441 homolog", "protein_names_refseq": "TATA-binding protein-like factor-interacting protein; TLF-interacting protein; TRF2-interacting protein in testis; spermatogenesis-associated protein 24 isoform 1; spermatogenesis-associated protein 24; testis protein T6441 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71242)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18418073;19515240;21750661;34428180", "class_list": "", "function": "Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis., [UniProtKB, PubMed, PubMed]; TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1., [RefSeq, PubMed]; TIPT2 synergizes with geminin and TBP in the activation of TATA box-containing promoters. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5MMR1;Q9D4P6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P926-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76N33-1", "uniprot_id": "STALP_MOUSE", "mass": 49640.0, "length": 436, "protein_name": "AMSH-like protease", "gene_name": "Stambpl1", "organism": "Mouse", "refseq_name": "AMSH-like protease isoform 1", "refseq_ac": "NP_083958", "gene_names_uniprotkb": "Stambpl1; Amshlp", "gene_names_refseq": "1700095N21Rik; 8230401J17Rik; ALMalpha; AMSH-FP; Stambpl1", "protein_names_uniprotkb": "AMSH-like protease; 3.4.19.-; AMSH family protein; AMSH-FP; AMSH-LP; STAM-binding protein-like 1", "protein_names_refseq": "AMSH-LP; AMSH-family protein; AMSH-like protease isoform 1; AMSH-like protease", "tax_id": 10090, "disease": "", "pathway": " (mmu:76630); (R-MMU-5689901)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12943674;21183079;21750661", "class_list": "", "function": "AMSH-FP is specifically expressed in haploid stages of testicular germ cells and has a functional role in spermiogenesis [AMSH-FP], [RefSeq, PubMed]; Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex. Does not cleave 'Lys-48'-linked polyubiquitin chains., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q76LY0;Q8VEK5", "ec_number_list": "3.4.19.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0061578 K63-linked deubiquitinase activity;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006508 proteolysis;GO:0070536 protein K63-linked deubiquitination;GO:0031669 cellular response to nutrient levels;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q76N33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQ48-2", "uniprot_id": "SRCA_MOUSE", "mass": 54287.0, "length": 472, "protein_name": "Sarcalumenin", "gene_name": "Srl", "organism": "Mouse", "refseq_name": "sarcalumenin isoform 2 precursor", "refseq_ac": "NP_001334091", "gene_names_uniprotkb": "Srl; Sar", "gene_names_refseq": "9830004M20Rik; Srl; sar", "protein_names_uniprotkb": "Sarcalumenin", "protein_names_refseq": "sarcalumenin isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:106393)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;15569689;15998745;17242355;18006473;19502553;22119571;23613228;36288343;37507081;39927985", "class_list": "", "function": "Results indicated that sine oculis homeobox 1 (Six1) overexpression could significantly promote the expression of fast-type muscle genes Atp2a1, Srl, and Mylpf., [RefSeq, PubMed]; SAR plays a critical role in maintaining cardiac function under physiological stresses, such as endurance exercise, by regulating Ca(2+) transport activity into the sarcoplasmic reticulum, [RefSeq, PubMed]; SAR plays important roles in improving the Ca2+ handling functions of the SR in striated muscle., [RefSeq, PubMed]; Sarcalumenin knockout mice have enhanced resistance to fatigue and altered calcium handling properties, [RefSeq, PubMed]; Sarcalumenin-SERCA2a interaction plays an essential role in preserving cardiac function under biomechanical stresses such as pressure overload., [RefSeq, PubMed]; The important role of SAR in maintaining Ca(2+) transport activity of SERCA2a and cardiac function in the senescent population, is reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6H5Y7;Q8BS43", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding", "go_cellular_component": "GO:0033017 sarcoplasmic reticulum membrane;GO:0033018 sarcoplasmic reticulum lumen", "go_biological_process": "GO:0014873 response to muscle activity involved in regulation of muscle adaptation;GO:0002115 store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q7TQ48-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VR3-1", "uniprot_id": "ST1C1_MOUSE", "mass": 35797.0, "length": 304, "protein_name": "Sulfotransferase 1C1", "gene_name": "Sult1c1", "organism": "Mouse", "refseq_name": "sulfotransferase 1C1", "refseq_ac": "NP_061221", "gene_names_uniprotkb": "Sult1c1; Sult1a2", "gene_names_refseq": "(PST)G; P-SULT; ST1C1; Stp2; Sult1a2; Sult1c1; mOLFST", "protein_names_uniprotkb": "Sulfotransferase 1C1; 2.8.2.-; Phenol sulfotransferase; ST1C1", "protein_names_refseq": "phenol sulfotransferase; sulfotransferase 1C1; sulfotransferase family 1A, phenol-preferring, member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20888)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8641270;9560327", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). Also shows activity towards cinnamyl alcohol at pH 6.4 but not at pH 5.5, and towards a number of phenolic odorants including eugenol, guaiacol and 2-naphthol., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70262", "ec_number_list": "", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0004027 alcohol sulfotransferase activity;GO:0047704 bile-salt sulfotransferase activity;GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0006805 xenobiotic metabolic process;GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0006790 sulfur compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80VR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BGX7-1", "uniprot_id": "SPIDR_MOUSE", "mass": 103297.0, "length": 933, "protein_name": "DNA repair-scaffolding protein", "gene_name": "Spidr", "organism": "Mouse", "refseq_name": "DNA repair-scaffolding protein isoform 1", "refseq_ac": "NP_666180", "gene_names_uniprotkb": "Spidr; Kiaa0146", "gene_names_refseq": "2310008H04Rik; Kiaa0146; Spidr", "protein_names_uniprotkb": "DNA repair-scaffolding protein; Scaffolding protein involved in DNA repair", "protein_names_refseq": "DNA repair-scaffolding protein isoform 1; DNA repair-scaffolding protein; scaffolding protein involved i DNA repair", "tax_id": 10090, "disease": "ovarian dysgenesis 9 (Disease Ontology:DOID:0061013)", "pathway": " (mmu:224008); (R-MMU-5693568)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "31219806;34253720;35820727;36938872", "class_list": "", "function": "Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in early stages DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:34253720). As part of the Shu complex, promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA (PubMed:34253720). The Shu complex is essential during meiosis by stabilizing DMC1 filaments (PubMed:34253720, PubMed:36938872). In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR) (PubMed:34253720). IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid (PubMed:34253720)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCD0;Q5U457;Q6A0B6;Q6IS60;Q811E1;Q8BWD6;Q8R305", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0070202 regulation of establishment of protein localization to chromosome;GO:0006974 DNA damage response;GO:0031334 positive regulation of protein-containing complex assembly;GO:0000724 double-strand break repair via homologous recombination;GO:0071479 cellular response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BGX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH69-1", "uniprot_id": "SPS1_MOUSE", "mass": 42907.0, "length": 392, "protein_name": "Selenide, water dikinase 1", "gene_name": "Sephs1", "organism": "Mouse", "refseq_name": "selenide, water dikinase 1 isoform a", "refseq_ac": "NP_780609", "gene_names_uniprotkb": "Sephs1; Sps1", "gene_names_refseq": "1110046B24Rik; SELD; SPS1; SPS; Sephs1", "protein_names_uniprotkb": "Selenide, water dikinase 1; 2.7.9.3; Selenium donor protein 1; Selenophosphate synthase 1", "protein_names_refseq": "selenide, water dikinase 1 isoform a; selenide, water dikinase 1; selenium donor protein 1; selenophosphate synthase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:109079)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16262699;17194211;17346238;27208177;34428180;34769076;34769078;34974300;35140209;36202216", "class_list": "", "function": "Constitutive Oxidative Stress by SEPHS1 Deficiency Induces Endothelial Cell Dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]; Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression (By similarity). The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif (By similarity). Within the complex, SEPHS1, recognizes and binds the backbone of zinc fingers of transcription factors in a sequence-independent manner via its arginine clamp, enhancing their DNA-binding stability (By similarity). Plays an essential role in redox homeostasis (PubMed:27208177, PubMed:34769076, PubMed:34769078, PubMed:35140209). May also be involved in selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP (By similarity). Its role in selenocysteine biosynthesis is however unclear and several studies suggest that it does not act as a selenophosphate synthase in vivo or plays an non-essential role (PubMed:17194211, PubMed:17346238). Required for cardiac differentiation (PubMed:34974300)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Data found that several malignant characteristics of SPS1-deficient F9 cells were reversed, suggesting that SPS1 played a role in supporting and/or sustaining cancer. Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals., [RefSeq, PubMed]; Identification of Signaling Pathways for Early Embryonic Lethality and Developmental Retardation in Sephs1(-/-) Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (mSPS1) and hDLP1 (mDLP1), [RefSeq, PubMed]; SEPHS1 is dispensable for pluripotency maintenance but indispensable for cardiac differentiation in mouse embryonic stem cells., [RefSeq, PubMed]; SEPHS1: Its evolution, function and roles in development and diseases., [RefSeq, PubMed]; Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.9.3", "go_molecular_function": "GO:0004756 selenide, water dikinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005694 chromosome", "go_biological_process": "GO:0016260 selenocysteine biosynthetic process;GO:0006351 DNA-templated transcription;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BH69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKA3-1", "uniprot_id": "SRRM4_MOUSE", "mass": 67860.0, "length": 608, "protein_name": "Serine/arginine repetitive matrix protein 4", "gene_name": "Srrm4", "organism": "Mouse", "refseq_name": "serine/arginine repetitive matrix protein 4 isoform a", "refseq_ac": "NP_081162", "gene_names_uniprotkb": "Srrm4", "gene_names_refseq": "1500001A10Rik; B230202K19Rik; Srrm4; bv; mKIAA1853; nSR100", "protein_names_uniprotkb": "Serine/arginine repetitive matrix protein 4; Neural-specific SR-related protein of 100 kDa; Neural-specific serine/arginine repetitive splicing factor of 100 kDa; nSR100", "protein_names_refseq": "neural-specific SR-related protein of 100 kDa; neural-specific serine/arginine repetitive splicing factor of 100 kDa; serine/arginine repetitive matrix protein 4 isoform a; serine/arginine repetitive matrix protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:68955)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19737518;21750661;21884984;25838543;27984743;33087486", "class_list": "", "function": "Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse. Publication Status: Online-Only, [RefSeq, PubMed]; Neuronal activity-dependent microexons are nSR100 targets and are misregulated in autism., [RefSeq, PubMed]; Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (PubMed:19737518). Promotes alternative splicing of REST transcripts to produce REST isoform 2 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells (PubMed:21884984). Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (PubMed:25838543)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1S5;Q9CW37", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0008380 RNA splicing;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BKA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C5V0-1", "uniprot_id": "SPT32_MOUSE", "mass": 37222.0, "length": 334, "protein_name": "Spermatogenesis-associated protein 32", "gene_name": "Spata32", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 32", "refseq_ac": "NP_808469", "gene_names_uniprotkb": "Spata32; Aep2; Vad1.2", "gene_names_refseq": "4933400C05Rik; Spata32; VAD1.2", "protein_names_uniprotkb": "Spermatogenesis-associated protein 32; Acrosome expressed protein 2", "protein_names_refseq": "acrosome expressed protein 2; spermatogenesis-associated protein 32", "tax_id": 10090, "disease": "", "pathway": " (mmu:328019)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12878178;18621766", "class_list": "", "function": "Identification and expression analysis of the rat VAD1.2 ortholog., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C5V0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C636-1", "uniprot_id": "SPT16_MOUSE", "mass": 65006.0, "length": 571, "protein_name": "Spermatogenesis-associated protein 16", "gene_name": "Spata16", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 16 isoform 1", "refseq_ac": "NP_081859", "gene_names_uniprotkb": "Spata16", "gene_names_refseq": "4921511F01Rik; 4930503K02Rik; Nyd-sp12; Spata16", "protein_names_uniprotkb": "Spermatogenesis-associated protein 16", "protein_names_refseq": "spermatogenesis-associated protein 16 isoform 1; spermatogenesis-associated protein 16; spermatogenesis-related protein", "tax_id": 10090, "disease": "spermatogenic failure 6 (Disease Ontology:DOID:0070167); male infertility (Disease Ontology:DOID:12336)", "pathway": " (mmu:70862)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12529416;16372119;29065458", "class_list": "", "function": "Essential for spermiogenesis and male fertility (PubMed:29065458). Involved in the formation of acrosome during spermatogenesis (PubMed:16372119)., [UniProtKB, PubMed, PubMed]; The point mutation in Spata16 was not essential for male fertility; however, deletion of the fourth exon of Spata16 resulted in infertile male mice due to spermiogenic arrest but not globozoospermia. This study demonstrates that Spata16 is indispensable for male fertility in mice, as well as in humans. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D5W9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C636-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C8J0-1", "uniprot_id": "STPG2_MOUSE", "mass": 62698.0, "length": 561, "protein_name": "Sperm-tail PG-rich repeat-containing protein 2", "gene_name": "Stpg2", "organism": "Mouse", "refseq_name": "sperm-tail PG-rich repeat-containing protein 2", "refseq_ac": "NP_941061", "gene_names_uniprotkb": "Stpg2", "gene_names_refseq": "B930007M17Rik; Gm1017; Stpg2", "protein_names_uniprotkb": "Sperm-tail PG-rich repeat-containing protein 2", "protein_names_refseq": "sperm-tail PG-rich repeat-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:381476)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18250455", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQW3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C8J0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CH02-1", "uniprot_id": "SUGP1_MOUSE", "mass": 72649.0, "length": 643, "protein_name": "SURP and G-patch domain-containing protein 1", "gene_name": "Sugp1", "organism": "Mouse", "refseq_name": "SURP and G-patch domain-containing protein 1", "refseq_ac": "NP_081757", "gene_names_uniprotkb": "Sugp1; Sf4", "gene_names_refseq": "5730496N02Rik; Sf4; Sugp1", "protein_names_uniprotkb": "SURP and G-patch domain-containing protein 1; Splicing factor 4", "protein_names_refseq": "SURP and G-patch domain-containing protein 1; splicing factor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:70616); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12594045;17242355;19144319;21183079;27206982;36852467", "class_list": "", "function": "Our results strongly support a role for SUGP1 as a novel regulator of cholesterol metabolism and suggest that it contributes to the relationship between rs10401969 and plasma cholesterol, [RefSeq, PubMed]; Plays a role in pre-mRNA splicing., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q0VAT9;Q3U0W3;Q8R094", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CH02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K1L2-1", "uniprot_id": "SPIN4_MOUSE", "mass": 28508.0, "length": 249, "protein_name": "Spindlin-4", "gene_name": "Spin4", "organism": "Mouse", "refseq_name": "spindlin-4", "refseq_ac": "NP_848868", "gene_names_uniprotkb": "Spin4", "gene_names_refseq": "9630042H07Rik; Spin4", "protein_names_uniprotkb": "Spindlin-4", "protein_names_refseq": "novel Spin/Ssty repeat containing protein; spindlin-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:270624)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34428180;36927955", "class_list": "", "function": "Binds to acetylated and methylated histones, including H3K4me3 and H4K20me3, probably acting as a histone reader that recognizes chromatin marks to mediate downstream cellular effects (By similarity). Promotes canonical WNT signaling, and is involved in the down-regulation of cell proliferation (PubMed:36927955)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXD0", "ec_number_list": "", "go_molecular_function": "GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0006355 regulation of DNA-templated transcription;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K1L2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2M3-1", "uniprot_id": "SRR1L_MOUSE", "mass": 27502.0, "length": 249, "protein_name": "SRR1-like protein", "gene_name": "Srrd", "organism": "Mouse", "refseq_name": "SRR1-like protein isoform 2", "refseq_ac": "NP_081599", "gene_names_uniprotkb": "Srrd", "gene_names_refseq": "2810002G02Rik; Srr1; Srrd", "protein_names_uniprotkb": "SRR1-like protein; SRR1 domain-containing protein", "protein_names_refseq": "SRR1 domain-containing protein; SRR1-like protein isoform 2; SRR1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:70118)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;28802827", "class_list": "", "function": "Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes., [UniProtKB, PubMed]; The expression of SRRD was dependent on heme biosynthesis, and increased the production of heme. SRRD was expressed under circadian rhythms, and influenced the expression of clock genes including PER2, BMAL1, and CLOCK., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08AU8;Q9CSK3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042752 regulation of circadian rhythm;GO:0048511 rhythmic process;GO:0006783 heme biosynthetic process;GO:0070453 regulation of heme biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K2M3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91VM4-1", "uniprot_id": "SPNS2_MOUSE", "mass": 58196.0, "length": 549, "protein_name": "Sphingosine-1-phosphate transporter SPNS2", "gene_name": "Spns2", "organism": "Mouse", "refseq_name": "sphingosine-1-phosphate transporter SPNS2 isoform 1", "refseq_ac": "NP_694700", "gene_names_uniprotkb": "Spns2", "gene_names_refseq": "Spns2", "protein_names_uniprotkb": "Sphingosine-1-phosphate transporter SPNS2; Protein spinster homolog 2; Spinster homolog 2; Spns2", "protein_names_refseq": "protein spinster homolog 2; sphingosine-1-phosphate transporter SPNS2 isoform 1; sphingosine-1-phosphate transporter SPNS2; spinster-like protein; spinster2", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 115 (Disease Ontology:DOID:0111643); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); sphingolipidosis (Disease Ontology:DOID:1927)", "pathway": " (mmu:216892); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "19074308;21084291;21750661;22406534;22664872;22723910;23103166;23180825;25356849;25605945;30084848;30779550;30973865;33785361;34260944;34428180;35988880;36198832", "class_list": "", "function": "Anomaly of cornea and ocular adnexa in spinster homolog 2 (Spns2) knockout mice., [RefSeq, PubMed]; Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate in the lymph, thereby playing a role in lymphocyte trafficking (PubMed:22406534, PubMed:22664872, PubMed:23103166, PubMed:23180825, PubMed:34260944). S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system (PubMed:22406534, PubMed:22664872, PubMed:23103166, PubMed:23180825, PubMed:34260944). Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking (PubMed:22406534, PubMed:22664872, PubMed:23180825, PubMed:34260944). Required for the egress of T-cells from lymph nodes during an immune response by mediating S1P secretion, which generates a gradient that enables activated T-cells to access lymph (PubMed:22406534, PubMed:34260944). Also required for the egress of immature B-cells from the bone marrow (PubMed:22406534). In contrast, it does not mediate S1P release from red blood cells (PubMed:22406534, PubMed:23103166). Involved in auditory function: S1P release in the inner ear is required for maintenance of the endocochlear potential in the cochlea (PubMed:25356849). In addition to export, also able to mediate S1P import (PubMed:33785361)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions. Publication Status: Online-Only, [RefSeq, PubMed]; SPNS2 is the first physiological S1P transporter in mammals and is a key determinant of lymphocyte egress from the thymus., [RefSeq, PubMed]; Spns2 functions in endothelial cells to establish the S1P gradient required for T and B cells to egress from their respective primary lymphoid organs., [RefSeq, PubMed]; The changes in lymphocyte subpopulations in mutant Spns2 mice closely mimick the phenotypes of partial sphingosine-1-phosphate (S1P) deficiency, impaired S1P-dependent lymphocyte trafficking, and depletion of circulating lymphocytes., [RefSeq, PubMed]; The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9A1T4;Q5F242;Q8R119", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0046624 sphingolipid transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0006869 lipid transport;GO:0006665 sphingolipid metabolic process;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q91VM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q922B2-1", "uniprot_id": "SYDC_MOUSE", "mass": 57147.0, "length": 501, "protein_name": "Aspartate--tRNA ligase, cytoplasmic", "gene_name": "Dars1", "organism": "Mouse", "refseq_name": "aspartate--tRNA ligase, cytoplasmic isoform 1", "refseq_ac": "NP_803228", "gene_names_uniprotkb": "Dars1; Dars", "gene_names_refseq": "5730439G15Rik; Dars1; Dars", "protein_names_uniprotkb": "Aspartate--tRNA ligase, cytoplasmic; 6.1.1.12; AspRS; Aspartyl-tRNA synthetase", "protein_names_refseq": "aspRS; aspartate--tRNA ligase, cytoplasmic isoform 1; aspartate--tRNA ligase, cytoplasmic; aspartyl-tRNA synthetase, cytoplasmic", "tax_id": 10090, "disease": "", "pathway": " (mmu:226414); (R-MMU-9856649)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12060739;25605945;27816769;29187734;31219806;33300544;34203471;34428180;36210013;37453647;37507081;39627609;40997131", "class_list": "", "function": "Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA., [UniProtKB, UniProtKB]; Study provides an in-depth characterization of the DARS tissue distribution in mice revealing surprising heterogeneity across brain regions and neural cell types, addresses the paucity of knowledge around Dars gene expression, cell and systems physiology and associated pathophysiology related to the leukodystrophy Hypomyelination with Brain stem and Spinal cord involvement and Leg spasticity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U987", "ec_number_list": "2.7.10.1;2.7.11.24;6.1.1.10;6.1.1.12;6.1.1.4;6.1.1.18;6.1.1.5;2.7.7.-;6.1.1.6;6.1.1.19", "go_molecular_function": "GO:0004815 aspartate-tRNA ligase activity;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex", "go_biological_process": "GO:0006422 aspartyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q922B2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q923B6-1", "uniprot_id": "STEA4_MOUSE", "mass": 52994.0, "length": 470, "protein_name": "Metalloreductase STEAP4", "gene_name": "Steap4", "organism": "Mouse", "refseq_name": "metalloreductase STEAP4", "refseq_ac": "NP_473439", "gene_names_uniprotkb": "Steap4; Tiarp", "gene_names_refseq": "1110021O17Rik; Steap4; Tiarp; Tnfaip9", "protein_names_uniprotkb": "Metalloreductase STEAP4; 1.16.1.-; Dudulin-4; Six-transmembrane epithelial antigen of prostate 4; Tumor necrosis factor-alpha-induced adipose-related protein", "protein_names_refseq": "Tnfa-induced adipose-related protein; dudulin 4; metalloreductase STEAP4; six-transmembrane epithelial antigen of prostate 4; tumor necrosis factor, alpha-induced protein 9; tumor necrosis factor-alpha-induced adipose-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:117167); (R-MMU-917977)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;11443137;14988015;16609065;17482547;19289123;19660107;30084848;30779550;33879167;34428180;35227772", "class_list": "", "function": "Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:16609065). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (PubMed:16609065). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (PubMed:17482547). Associated with obesity and insulin-resistance (By similarity). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; SSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes., [RefSeq, PubMed]; STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis. Publication Status: Online-Only, [RefSeq, PubMed]; Tiarp is stimulated by tumor necrosis factor-alpha in adipocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91W31;Q91ZE8", "ec_number_list": "1.16.1.-", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0020037 heme binding;GO:0008823 cupric reductase (NADH) activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0045444 fat cell differentiation;GO:0070207 protein homotrimerization;GO:0015677 copper ion import;GO:0098706 iron ion import across cell outer membrane;GO:0033212 iron import into cell", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q923B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CQ26-1", "uniprot_id": "STABP_MOUSE", "mass": 48514.0, "length": 424, "protein_name": "STAM-binding protein", "gene_name": "Stambp", "organism": "Mouse", "refseq_name": "STAM-binding protein", "refseq_ac": "NP_077201", "gene_names_uniprotkb": "Stambp; Amsh", "gene_names_refseq": "5330424L14Rik; 5730422L11Rik; Amsh; Stambp; mKIAA4198", "protein_names_uniprotkb": "STAM-binding protein; 3.4.19.-; Associated molecule with the SH3 domain of STAM", "protein_names_refseq": "STAM-binding protein; associated molecule with the SH3 domain of STAM", "tax_id": 10090, "disease": "", "pathway": " (mmu:70527); (R-MMU-5689901)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11713295;21531206;34428180", "class_list": "", "function": "These data suggest that AMSH plays an important role in degrading ubiquitinated proteins and glutamate receptors in vivo, [RefSeq, PubMed]; Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTI9", "ec_number_list": "3.4.19.-", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0061578 K63-linked deubiquitinase activity;GO:0101005 deubiquitinase activity;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0070536 protein K63-linked deubiquitination;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQ26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CY97-1", "uniprot_id": "SSU72_MOUSE", "mass": 22517.0, "length": 194, "protein_name": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "gene_name": "Ssu72", "organism": "Mouse", "refseq_name": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "refseq_ac": "NP_081175", "gene_names_uniprotkb": "Ssu72", "gene_names_refseq": "1190002E22Rik; 1500011L16Rik; 2610101M12Rik; Ssu72", "protein_names_uniprotkb": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72; 3.1.3.16; CTD phosphatase SSU72", "protein_names_refseq": "CTD phosphatase SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "tax_id": 10090, "disease": "liver disease (Disease Ontology:DOID:409)", "pathway": " (mmu:68991); (R-MMU-6807505)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15659578;19188448;32910932;33850312;34428180;34452999;36841836", "class_list": "", "function": "Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK., [UniProtKB, PubMed]; Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells., [RefSeq, PubMed]; Ssu72 phosphatase directly binds to ZAP-70, thereby providing fine-tuning of TCR signaling and preventing spontaneous inflammation., [RefSeq, PubMed]; Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Publication Status: Online-Only, [RefSeq, PubMed]; Ssu72 regulates alveolar macrophage development and allergic airway inflammation by fine-tuning of GM-CSF receptor signaling., [RefSeq, PubMed]; The amino terminus of Pta1 has an inhibitory effect and that this effect can be neutralized through the interaction with Ssu72., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UF99;Q91YL1;Q9DB51", "ec_number_list": "3.1.3.67;3.1.3.-;3.1.3.16;3.1.3.48;3.1.13.-;2.7.7.48;2.7.7.6;3.1.3.74;3.1.3.53;2.3.1.48;2.7.11.22;2.7.11.23;2.7.11.24;3.1.3.27;3.1.3.52;3.1.3.86;3.1.3.36;3.1.27.-", "go_molecular_function": "GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006369 termination of RNA polymerase II transcription;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CY97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D232-1", "uniprot_id": "SPNS3_MOUSE", "mass": 55456.0, "length": 514, "protein_name": "Protein spinster homolog 3", "gene_name": "Spns3", "organism": "Mouse", "refseq_name": "protein spinster homolog 3", "refseq_ac": "NP_084208", "gene_names_uniprotkb": "Spns3", "gene_names_refseq": "9830002I17Rik; Spns3", "protein_names_uniprotkb": "Protein spinster homolog 3", "protein_names_refseq": "protein spinster homolog 3; spinster homolog 3", "tax_id": 10090, "disease": "neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); sphingolipidosis (Disease Ontology:DOID:1927)", "pathway": " (mmu:77577)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sphingolipid transporter., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RX04;Q3U0X5;Q8BYA9", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D232-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5V6-1", "uniprot_id": "SYAP1_MOUSE", "mass": 41350.0, "length": 365, "protein_name": "Synapse-associated protein 1", "gene_name": "Syap1", "organism": "Mouse", "refseq_name": "synapse-associated protein 1", "refseq_ac": "NP_080208", "gene_names_uniprotkb": "Syap1", "gene_names_refseq": "2010110O17Rik; BSTA; Syap1", "protein_names_uniprotkb": "Synapse-associated protein 1; BSD domain-containing signal transducer and Akt interactor protein; BSTA", "protein_names_refseq": "BSD domain-containing signal transducer and Akt interactor protein; synapse-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67043)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;18322192;21183079;23300339;26495903;27344443;34428180;37669921", "class_list": "", "function": "Dlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation. Publication Status: Online-Only, [RefSeq, PubMed]; Findings demonstrate a widespread expression of Syap1 in the mouse central nervous system with regionally specific distribution patterns as illustrated in particular for olfactory bulb, hippocampus, and cerebellum; importantly, Syap1 knockout does not affect motoneuron survival or axon growth, [RefSeq, PubMed]; Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UI67;Q9D870", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0030154 cell differentiation;GO:0032869 cellular response to insulin stimulus;GO:0045600 positive regulation of fat cell differentiation;GO:0071902 positive regulation of protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D5V6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DA57-1", "uniprot_id": "SPT25_MOUSE", "mass": 23548.0, "length": 226, "protein_name": "Spermatogenesis-associated protein 25", "gene_name": "Spata25", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 25", "refseq_ac": "NP_083646", "gene_names_uniprotkb": "Spata25; Tsg23", "gene_names_refseq": "1700020C07Rik; Spata25; Tsg23", "protein_names_uniprotkb": "Spermatogenesis-associated protein 25; Testis-specific gene 23 protein", "protein_names_refseq": "spermatogenesis-associated protein 25; testis-specific gene 23 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:75642)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19240080", "class_list": "", "function": "May play a role in spermatogenesis., [UniProtKB]; Study identified a novel gene, TSG23/Tsg23, which is developmentally & highly expressed in testis; data suggest that TSG23/Tsg23 is involved in human and mouse spermatogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A5J4;Q14B41", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DA57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DBN1-1", "uniprot_id": "STR6L_MOUSE", "mass": 71003.0, "length": 621, "protein_name": "Stimulated by retinoic acid gene 6 protein-like", "gene_name": "Stra6l", "organism": "Mouse", "refseq_name": "stimulated by retinoic acid gene 6 protein-like isoform 2", "refseq_ac": "NP_001292350", "gene_names_uniprotkb": "Stra6l; Rbpr2", "gene_names_refseq": "1300002K09Rik; Rbpr2; Stra6l", "protein_names_uniprotkb": "Stimulated by retinoic acid gene 6 protein-like; RBP4 receptor 2; Retinol-binding protein 4 receptor 2; STRA6-like protein", "protein_names_refseq": "RBP4 receptor 2; STRA6-like protein; retinol-binding protein 4 receptor 2; stimulated by retinoic acid gene 6 protein-like isoform 2; stimulated by retinoic acid gene 6 protein-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:74152)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;23105095;33065162;34428180;35745101", "class_list": "", "function": "Acts as a high-affinity cell-surface receptor for retinol-binding protein RBP4 and mediates RBP4-dependent retinol uptake in the liver., [UniProtKB, PubMed]; Mice Lacking the Systemic Vitamin A Receptor RBPR2 Show Decreased Ocular Retinoids and Loss of Visual Function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AWX8;Q14DP6;Q14DS9;Q8C7I6", "ec_number_list": "", "go_molecular_function": "GO:0034632 retinol transmembrane transporter activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0034633 retinol transport;GO:0071939 vitamin A import into cell", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DBN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJ94-1", "uniprot_id": "SSNA1_MOUSE", "mass": 13557.0, "length": 119, "protein_name": "Microtubule nucleation factor SSNA1", "gene_name": "Ssna1", "organism": "Mouse", "refseq_name": "microtubule nucleation factor SSNA1", "refseq_ac": "NP_075953", "gene_names_uniprotkb": "Ssna1; MNCb-2711", "gene_names_refseq": "1110003H09Rik; 1190004J23Rik; N14; NA14; Ssna1", "protein_names_uniprotkb": "Microtubule nucleation factor SSNA1; Sjoegren syndrome nuclear autoantigen 1 homolog", "protein_names_refseq": "Sjogren's syndrome nuclear autoantigen 1; microtubule nucleation factor SSNA1; sjoegren syndrome nuclear autoantigen 1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68475); (R-MMU-2565942); (R-MMU-380259); (R-MMU-380270); (R-MMU-380284); (R-MMU-380320); (R-MMU-5620912); (R-MMU-8854518)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "18459117;22872234;25428506;30084848;30250060;30779550;34428180", "class_list": "", "function": "Data show that the simple scaffolding mechanism of SS nuclear autoantigen 1 (SSNA1) can lead to vast morphological changes in neurons., [RefSeq, PubMed]; Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST (By similarity). Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules (By similarity). Plays a role in axon outgrowth and branching (PubMed:30250060). Required for cell division (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; The functional plasma membrane transport of TPRA40 that regulates cell division of mouse embryos is mediated by NA14, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007409 axonogenesis;GO:0051301 cell division;GO:0007020 microtubule nucleation;GO:0000226 microtubule cytoskeleton organization;GO:0043113 receptor clustering", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JJ94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKK1-1", "uniprot_id": "STX6_MOUSE", "mass": 28997.0, "length": 255, "protein_name": "Syntaxin-6", "gene_name": "Stx6", "organism": "Mouse", "refseq_name": "syntaxin-6", "refseq_ac": "NP_067408", "gene_names_uniprotkb": "Stx6", "gene_names_refseq": "2310039E05Rik; 2410005I16Rik; Stx6", "protein_names_uniprotkb": "Syntaxin-6", "protein_names_refseq": "syntaxin-6", "tax_id": 10090, "disease": "", "pathway": " (mmu:58244); (R-MMU-6811438); (R-MMU-6811440)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15640147;17322886;21750661;26495903;32152506;37996040;9705316", "class_list": "", "function": "Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6., [RefSeq, PubMed]; SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway., [UniProtKB, UniProtKB]; Syntaxin 6 and Vti1b form a SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D3A1;Q9D729", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0032880 regulation of protein localization;GO:0007032 endosome organization;GO:0016192 vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JKK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QWG7-1", "uniprot_id": "ST1B1_MOUSE", "mass": 34901.0, "length": 299, "protein_name": "Sulfotransferase 1B1", "gene_name": "Sult1b1", "organism": "Mouse", "refseq_name": "sulfotransferase 1B1", "refseq_ac": "NP_063931", "gene_names_uniprotkb": "Sult1b1", "gene_names_refseq": "ST1B1; St2b2; Sult1b1", "protein_names_uniprotkb": "Sulfotransferase 1B1; 2.8.2.1; DOPA/tyrosine sulfotransferase; ST1B1; Sulfotransferase family cytosolic 1B member 1", "protein_names_refseq": "dopa/tyrosine sulfotransferase; sulfotransferase 1B1; sulfotransferase family cytosolic 1B member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56362); (R-MMU-156584)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "18815351;20720434;30084848;9644246", "class_list": "", "function": "MSult1b1 is suggested as a major enzyme responsible for XA sulfation in jejunum, [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:9644246). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (By similarity)., [UniProtKB, PubMed, UniProtKB]; Sult1b1 may be involved in the sulfonylation of podocyte protein podocalyxin, whereas ankrd25 may contribute to controlling actin dynamics in podocyte foot processes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C301;Q9Z2T0", "ec_number_list": "2.8.2.-;2.8.2.n2;2.8.2.4;2.8.2.2;2.8.2.1", "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0030855 epithelial cell differentiation;GO:0006068 ethanol catabolic process;GO:0006805 xenobiotic metabolic process;GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QWG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QXV8-1", "uniprot_id": "SPY2_MOUSE", "mass": 34623.0, "length": 315, "protein_name": "Protein sprouty homolog 2", "gene_name": "Spry2", "organism": "Mouse", "refseq_name": "protein sprouty homolog 2", "refseq_ac": "NP_036027", "gene_names_uniprotkb": "Spry2", "gene_names_refseq": "Spry2; sprouty2", "protein_names_uniprotkb": "Protein sprouty homolog 2; Spry-2", "protein_names_refseq": "protein sprouty homolog 2; sprouty homolog 2; spry-2", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); intestinal pseudo-obstruction (Disease Ontology:DOID:0080072); IgA glomerulonephritis (Disease Ontology:DOID:2986); achalasia (Disease Ontology:DOID:9164)", "pathway": " (mmu:24064); (R-MMU-1295596); (R-MMU-182971)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10074434;10498682;16877379;17974561;18678649;22645316;25576668;29501879;31219806;32848054;39174793", "class_list": "", "function": "Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (PubMed:10074434, PubMed:10498682, PubMed:29501879). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (PubMed:25576668). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUQ9", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0019901 protein kinase binding;GO:0004860 protein kinase inhibitor activity;GO:0043539 protein serine/threonine kinase activator activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0015629 actin cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration;GO:0033138 positive regulation of peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9QXV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0M3-1", "uniprot_id": "SRPX_MOUSE", "mass": 51574.0, "length": 464, "protein_name": "Sushi-repeat-containing protein SRPX", "gene_name": "Srpx", "organism": "Mouse", "refseq_name": "sushi-repeat-containing protein SRPX isoform 1 precursor", "refseq_ac": "NP_058607", "gene_names_uniprotkb": "Srpx", "gene_names_refseq": "DRS-1; DRS-2; Srpx; drs-1; drs-2; drs", "protein_names_uniprotkb": "Sushi-repeat-containing protein SRPX; DRS protein", "protein_names_refseq": "sushi-repeat-containing protein SRPX isoform 1 precursor; sushi-repeat-containing protein SRPX; sushi-repeat-containing protein, X-chromosome", "tax_id": 10090, "disease": "", "pathway": " (mmu:51795)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12049817;17088259;19368996;21750661;21983129;25620379;28478503", "class_list": "", "function": "Drs is involved in the maturation process of autophagy from autophagosomes to autolysosomes, [RefSeq, PubMed]; Drs regulates glucose metabolism via LDH-B. Downregulating drs may contribute to the Warburg effect, which is closely associated with malignant progression of cancer cells., [RefSeq, PubMed]; Drs suppresses viral replication via mTOR-dependent pathway., [RefSeq, PubMed]; Isolation of a novel variant of the tumor suppressor gene (mDRS-2), [RefSeq, PubMed]; SRPX1 co-accumulated with Abeta deposits in cerebral blood vessels of all autopsied cases with severe cerebral amyloid angiopathy (CAA); no SRPX1 co-accumulated with Abeta deposits in senile plaques. Furthermore, we demonstrated that both Abeta40 and Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in primary cultures of cerebrovascular smooth muscle cells. SRPX1 enhanced caspase activity induced by Abeta40., [RefSeq, PubMed]; Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2BE46;A2BE47;Q9R0M2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005776 autophagosome", "go_biological_process": "GO:0060244 negative regulation of cell proliferation involved in contact inhibition;GO:0006914 autophagy;GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0034976 response to endoplasmic reticulum stress;GO:0001845 phagolysosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9R0M3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0U0-1", "uniprot_id": "SRS10_MOUSE", "mass": 31301.0, "length": 262, "protein_name": "Serine/arginine-rich splicing factor 10", "gene_name": "Srsf10", "organism": "Mouse", "refseq_name": "serine/arginine-rich splicing factor 10 isoform 2", "refseq_ac": "NP_001073856", "gene_names_uniprotkb": "Srsf10; Fusip1; Nssr; Sfrs13a; Srsf13a", "gene_names_refseq": "FUSIP2; Fusip1; NSSR1; NSSR2; Nssr; SRrp40; Sfrs13a; Srsf10; Srsf13a; TASR1; TASR2; TASR", "protein_names_uniprotkb": "Serine/arginine-rich splicing factor 10; FUS-interacting serine-arginine-rich protein 1; Neural-salient serine/arginine-rich protein; Neural-specific SR protein; Splicing factor, arginine/serine-rich 13A; TASR; TLS-associated SR protein; TLS-associated protein with SR repeats; TLS-associated protein with Ser-Arg repeats; TLS-associated serine-arginine protein", "protein_names_refseq": "FUS-interacting serine-arginine-rich protein 1; Fus-associated protein with serine-arginine repeats; TLS-associated SR protein; TLS-associated protein with SR repeats; TLS-associated protein with Ser-Arg repeats; TLS-associated serine-arginine protein; neural-salient serine/arginine-rich protein; neural-specific SR protein; serine/arginine-rich splicing factor 10 isoform 2; serine/arginine-rich splicing factor 10; serine/arginine-rich splicing factor 13A", "tax_id": 10090, "disease": "macular degeneration (Disease Ontology:DOID:4448)", "pathway": " (mmu:14105); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10583508;10779324;17242355;21183079;22645316;32338600;35293570;36355419;38960088;9774382", "class_list": "", "function": "Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease., [RefSeq, PubMed]; SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing. Publication Status: Online-Only, [RefSeq, PubMed]; SRSF10 regulates migration of neural progenitor cells and granule cells and affects the formation of dentate gyrus during the development of mouse hippocampus., [RefSeq, PubMed]; Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (By similarity). May be involved in regulation of alternative splicing in neurons (PubMed:10583508)., [UniProtKB, PubMed, UniProtKB]; Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AV44;B1AV45;O70307;O88468;Q3TGW7;Q8CFZ1;Q9R0T9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0006355 regulation of DNA-templated transcription;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0000398 mRNA splicing, via spliceosome;GO:0016482 cytosolic transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9R0U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q717B2-1", "uniprot_id": "TDPZ2_MOUSE", "mass": 41537.0, "length": 364, "protein_name": "TD and POZ domain-containing protein 2", "gene_name": "Tdpoz2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tdpoz2; Gm5773", "gene_names_refseq": "", "protein_names_uniprotkb": "TD and POZ domain-containing protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:399673)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14693377;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RUE5;E9QNP4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis;GO:0000209 protein polyubiquitination;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q717B2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48030-1", "uniprot_id": "TGFA_MOUSE", "mass": 17018.0, "length": 159, "protein_name": "Protransforming growth factor alpha", "gene_name": "Tgfa", "organism": "Mouse", "refseq_name": "protransforming growth factor alpha isoform 1 preproprotein", "refseq_ac": "NP_112476", "gene_names_uniprotkb": "Tgfa", "gene_names_refseq": "Tgfa; wa-1; wa1", "protein_names_uniprotkb": "Protransforming growth factor alpha; EGF-like TGF; ETGF; TGF type 1", "protein_names_refseq": "protransforming growth factor alpha isoform 1 preproprotein; protransforming growth factor alpha", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); pancreatic cancer (Disease Ontology:DOID:1793); gastroenteritis (Disease Ontology:DOID:2326); acute kidney failure (Disease Ontology:DOID:3021); insulinoma (Disease Ontology:DOID:3892); gallbladder carcinoma (Disease Ontology:DOID:4948); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:21802); (R-MMU-1257604); (R-MMU-177929); (R-MMU-179812); (R-MMU-180292); (R-MMU-180336); (R-MMU-182971); (R-MMU-204005); (R-MMU-212718); (R-MMU-5673001); (R-MMU-5694530); (R-MMU-6811558); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-9009391)", "pathway_count": 15, "publication_count": 4, "publication_id_list": "1420315;15652357;21750661;8877107", "class_list": "", "function": "TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar., [UniProtKB]; This gene encodes a member of the epidermal growth factor (EGF) family of proteins that regulate cellular proliferation. The encoded protein undergoes proteolytic processing to generate a soluble glycoprotein that is secreted by the cell. The secreted protein binds to the EGF receptors to initiate signaling events resulting in cellular proliferation, mucous production or inhibition of gastric acid secretion. The transgenic expression of the encoded protein in mice induces the development of cancers in various tissues such as liver, pancreas, skin and mammary glands. Mice lacking the encoded protein exhibit a wavy coat and curly whiskers phenotype as well as abnormalities in the eye. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0072574 hepatocyte proliferation;GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P48030-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D8P7-1", "uniprot_id": "TF3C6_MOUSE", "mass": 25548.0, "length": 227, "protein_name": "General transcription factor 3C polypeptide 6", "gene_name": "Gtf3c6", "organism": "Mouse", "refseq_name": "general transcription factor 3C polypeptide 6 isoform 2", "refseq_ac": "NP_080389", "gene_names_uniprotkb": "Gtf3c6", "gene_names_refseq": "2410016F19Rik; Gtf3c6", "protein_names_uniprotkb": "General transcription factor 3C polypeptide 6; TFIIIC 35 kDa subunit; TFIIIC35; Transcription factor IIIC 35 kDa subunit; Transcription factor IIIC subunit 6", "protein_names_refseq": "TFIIIC 35 kDa subunit; TFIIIC35; general transcription factor 3C polypeptide 6 isoform 2; general transcription factor 3C polypeptide 6; transcription factor IIIC 35 kDa subunit; transcription factor IIIC subunit 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:67371); (R-MMU-76061); (R-MMU-76066)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "20173027;21750661;25428506;30084848;30779550;31599954", "class_list": "", "function": "Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2T6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0000127 transcription factor TFIIIC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006383 transcription by RNA polymerase III;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D8P7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A8T7-1", "uniprot_id": "TEX38_MOUSE", "mass": 22716.0, "length": 201, "protein_name": "Testis-expressed protein 38", "gene_name": "Tex38", "organism": "Mouse", "refseq_name": "testis-expressed protein 38", "refseq_ac": "NP_083472", "gene_names_uniprotkb": "Tex38", "gene_names_refseq": "4930544O15Rik; Tex38; Theg4", "protein_names_uniprotkb": "Testis-expressed protein 38; ATPAF1 antisense RNA 1; ATPAF1 antisense gene protein 1", "protein_names_refseq": "ATPAF1 antisense RNA 1; ATPAF1 antisense gene protein 1; testis highly expressed protein 4; testis-expressed protein 38; testis-expressed sequence 38 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:75173)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "40030029", "class_list": "", "function": "Plays an essential role in male fertility. TEX38 and ZDHHC19 form a complex in developing sperm. This complex regulates S-palmitoylation of the proteins that are essential for generating functional sperm with the correct morphology., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D4X3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A8T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3US16-1", "uniprot_id": "TEANC_MOUSE", "mass": 40635.0, "length": 359, "protein_name": "Transcription elongation factor A N-terminal and central domain-containing protein", "gene_name": "Tceanc", "organism": "Mouse", "refseq_name": "transcription elongation factor A N-terminal and central domain-containing protein", "refseq_ac": "NP_001007578", "gene_names_uniprotkb": "Tceanc", "gene_names_refseq": "A630018P17Rik; Gm390; Tceanc", "protein_names_uniprotkb": "Transcription elongation factor A N-terminal and central domain-containing protein; TFIIS central domain-containing protein 1", "protein_names_refseq": "TFIIS central domain-containing protein 1; TFS2-M domain-containing protein 1; novel transcription factor S-II (TFIIS), central domain containing protein; transcription elongation factor A N-terminal and central domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:245695)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NXL9;Q8BY92", "ec_number_list": "", "go_molecular_function": "GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3US16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A8C756-1", "uniprot_id": "THADA_MOUSE", "mass": 217289.0, "length": 1938, "protein_name": "tRNA (32-2'-O)-methyltransferase regulator THADA", "gene_name": "Thada", "organism": "Mouse", "refseq_name": "tRNA (32-2'-O)-methyltransferase regulator THADA", "refseq_ac": "NP_898842", "gene_names_uniprotkb": "Thada; Kiaa1767", "gene_names_refseq": "6530405K19; A930021O22; GITA; Thada", "protein_names_uniprotkb": "tRNA (32-2'-O)-methyltransferase regulator THADA; Thyroid adenoma-associated protein homolog", "protein_names_refseq": "tRNA (32-2'-O)-methyltransferase regulator THADA; thyroid adenoma-associated protein homolog", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:240174)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17889454;21183079;22872234;25428506;30084848;34428180;35480478;36823211;37828378", "class_list": "", "function": "A domain of Thada conserved in vertebrates becomes destroyed by chromosomal rerrangements observed in thyroid adenomas., [RefSeq, PubMed]; THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic beta-cell function and preserving beta-cell mass. Publication Status: Online-Only, [RefSeq, PubMed]; Thada Is Dispensable for Female Fertility in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDR4;Q3U2L1;Q69ZA8;Q7TPV7;Q8C8S7", "ec_number_list": "", "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0002128 tRNA nucleoside ribose methylation;GO:0055088 lipid homeostasis;GO:0030488 tRNA methylation;GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A8C756-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DA15-1", "uniprot_id": "SMA2L_MOUSE", "mass": 51801.0, "length": 459, "protein_name": "Sperm microtubule associated protein 2-like", "gene_name": "Spmap2l", "organism": "Mouse", "refseq_name": "sperm microtubule associated protein 2-like isoform 1", "refseq_ac": "NP_082246", "gene_names_uniprotkb": "Spmap2l; 1700023E05Rik; Thegl", "gene_names_refseq": "1700023E05Rik; Spmap2l; Thegl", "protein_names_uniprotkb": "Sperm microtubule associated protein 2-like; Testicular haploid expressed gene protein-like; Theg spermatid-like protein", "protein_names_refseq": "sperm microtubule associated protein 2-like isoform 1; theg spermatid protein like; theg spermatid-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71868)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;27357688", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DA15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4I4-1", "uniprot_id": "TF2AY_MOUSE", "mass": 51525.0, "length": 468, "protein_name": "TFIIA-alpha and beta-like factor", "gene_name": "Gtf2a1l", "organism": "Mouse", "refseq_name": "TFIIA-alpha and beta-like factor", "refseq_ac": "NP_076119", "gene_names_uniprotkb": "Gtf2a1l; Alf; Gtf2a1lf", "gene_names_refseq": "1700011N16Rik; Alf; Gtf2a1lf; Gtf2a1l", "protein_names_uniprotkb": "TFIIA-alpha and beta-like factor; General transcription factor II A, 1-like factor", "protein_names_refseq": "TFIIA-alpha and beta-like factor; TfIIa-alpha/beta-like factor; general transcription factor II A, 1-like factor; general transcription factor IIA, 1-like factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:71828)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11159353;11889132;12107178;15151936;15927180;21750661;24176642;33353944", "class_list": "", "function": "A role for ALF in the assembly and stabilization of initiation complexes in germ cells is likely to be similar or identical to the role of TFIIA in somatic cells., [RefSeq, PubMed]; Endogenous ALF is proteolytically cleaved to give alpha- and beta-subunits and its cleavage site was mapped., [RefSeq, PubMed]; May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription., [UniProtKB]; TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage. Publication Status: Online-Only, [RefSeq, PubMed]; Taspase1 cleaves a ubiquitously expressed GTF (TFIIA) to enable tissue-specific (testis) transcription, meeting the demand for sophisticated regulation of distinct subsets of genes in higher organisms., [RefSeq, PubMed]; Unique core promoter that is active in both male and female reproductive tissue suggesting ALF may have a regulatory role in male and female gametogenic gene expression programs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99PM2;Q9DAF4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005672 transcription factor TFIIA complex", "go_biological_process": "GO:0050890 cognition;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R4I4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6YCH1-1", "uniprot_id": "TDPZ5_MOUSE", "mass": 38827.0, "length": 340, "protein_name": "TD and POZ domain-containing protein 5", "gene_name": "Tdpoz5", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tdpoz5; Tdpoz7", "gene_names_refseq": "", "protein_names_uniprotkb": "TD and POZ domain-containing protein 5", "protein_names_refseq": "", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:100042761); (mmu:399676)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14693377;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis;GO:0000209 protein polyubiquitination;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6YCH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9J2-1", "uniprot_id": "CMIP4_MOUSE", "mass": 30228.0, "length": 266, "protein_name": "Ciliary microtubule inner protein 4", "gene_name": "Cimip4", "organism": "Mouse", "refseq_name": "ciliary microtubule inner protein 4 isoform 1", "refseq_ac": "NP_001157084", "gene_names_uniprotkb": "Cimip4; 1700061J05Rik; Ean57; Tex33", "gene_names_refseq": "1700061J05Rik; Cimip4; Ean57; Tex33", "protein_names_uniprotkb": "Ciliary microtubule inner protein 4; Testis-expressed protein 33", "protein_names_refseq": "ciliary microtubule inner protein 4 isoform 1; protein EAN57; testis expressed 33; testis-expressed protein 33; testis-expressed sequence 33 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:73376)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17971504;21750661;28742876;32821546;33760102", "class_list": "", "function": "1700061J05Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Seems to be associated with spermiogenesis but is not essential for sperm development and male fertility., [UniProtKB, PubMed, PubMed]; Testis-expressed protein 33 is not essential for spermiogenesis and fertility in mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D9J2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36423-1", "uniprot_id": "THAS_MOUSE", "mass": 60391.0, "length": 533, "protein_name": "Thromboxane-A synthase", "gene_name": "Tbxas1", "organism": "Mouse", "refseq_name": "thromboxane-A synthase isoform 1", "refseq_ac": "NP_035669", "gene_names_uniprotkb": "Tbxas1; Cyp5a1; Cyp5", "gene_names_refseq": "CYP5A1; CYP5; THAS; TS; TXAS; TXS; Tbxas1", "protein_names_uniprotkb": "Thromboxane-A synthase; 4.2.1.152; 5.3.99.5; Cytochrome P450 5A1; Hydroperoxy icosatetraenoate dehydratase; TS; TXA synthase; TXS", "protein_names_refseq": "TXA synthase; cytochrome P450 5A1; hydroperoxy icosatetraenoate dehydratase; thromboxane synthase; thromboxane-A synthase isoform 1; thromboxane-A synthase", "tax_id": 10090, "disease": "thrombosis (Disease Ontology:DOID:0060903); alcohol-associated liver disease (Disease Ontology:DOID:0070658); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Ghosal hematodiaphyseal syndrome (Disease Ontology:DOID:0112251); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); hydronephrosis (Disease Ontology:DOID:11111); arteriosclerosis (Disease Ontology:DOID:2349); glomerulonephritis (Disease Ontology:DOID:2921); brain infarction (Disease Ontology:DOID:3454); cerebral infarction (Disease Ontology:DOID:3526); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (mmu:21391); (R-MMU-211979); (R-MMU-2162123)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "15010374;20173027;21750661;26974824;30084848;30300909;30779550;31219806;34428180;7688225;9367676", "class_list": "", "function": "Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE., [UniProtKB, UniProtKB]; The administration of salted drinking water (2.7% NaCl) to wild-type mice resulted in elevated placental TXA2 synthase (TXAS) and plasma thromboxane A2, but not prostacyclin, levels, which was also found in clinical preeclampsia placenta samples. Publication Status: Online-Only, [RefSeq, PubMed]; This study shows that genetic depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor signaling prevents microvascular dysfunction in ischemia reperfusion injury, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97505", "ec_number_list": "5.3.99.4;4.2.1.152;1.14.14.1;5.3.99.5;1.14.99.1;5.3.99.3;1.14.14.-;5.4.4.7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0004796 thromboxane-A synthase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006690 icosanoid metabolic process;GO:0030644 intracellular chloride ion homeostasis;GO:0045471 response to ethanol;GO:0045907 positive regulation of vasoconstriction;GO:0070542 response to fatty acid", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36423-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80W22-1", "uniprot_id": "THNS2_MOUSE", "mass": 54188.0, "length": 483, "protein_name": "Threonine synthase-like 2", "gene_name": "Thnsl2", "organism": "Mouse", "refseq_name": "threonine synthase-like 2", "refseq_ac": "NP_001029101", "gene_names_uniprotkb": "Thnsl2", "gene_names_refseq": "TSH2; Thnsl2", "protein_names_uniprotkb": "Threonine synthase-like 2; 4.2.3.-; TSH2; mTSH2", "protein_names_refseq": "threonine synthase-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:232078)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17034760;21750661;25428506;30084848;34428180", "class_list": "glycogene", "function": "Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate. Also degrades O-phospho-homoserine (PHS), but this is not its physiological substrate., [UniProtKB, PubMed]; In vitro, the protein encoded by BC051244 acts as a phospho-lyase on large, phosphorylated amino acids. For example, it degrades O-phospho-threonine to ketobutyrate, phosphate, and ammonia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 34, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R135", "ec_number_list": "", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0016829 lyase activity;GO:0016791 phosphatase activity;GO:0070905 serine binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80W22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DMR5-1", "uniprot_id": "TDPZ1_MOUSE", "mass": 41584.0, "length": 365, "protein_name": "TD and POZ domain-containing protein 1", "gene_name": "Tdpoz1", "organism": "Mouse", "refseq_name": "TD and POZ domain-containing protein 1", "refseq_ac": "NP_683751", "gene_names_uniprotkb": "Tdpoz1; 2cpoz56; Mapp2; Spopl1", "gene_names_refseq": "2cpoz56; Mapp2; Spopl1; Tdpoz1", "protein_names_uniprotkb": "TD and POZ domain-containing protein 1; MAPP family protein 2", "protein_names_refseq": "MAPP family protein 2; MATH- and POZ-encompassing protein 2; POZ 56 protein; TD and POZ domain-containing protein 1", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:207213)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11424210;14693377", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q717B3;Q71G58;Q8BZV7;Q8VI39", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0DMR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DMR6-1", "uniprot_id": "TDP1L_MOUSE", "mass": 41674.0, "length": 365, "protein_name": "TD and POZ domain-containing protein 1-like", "gene_name": "Gm9125", "organism": "Mouse", "refseq_name": "TD and POZ domain-containing protein 1-like", "refseq_ac": "NP_001157202", "gene_names_uniprotkb": "Gm9125", "gene_names_refseq": "EG668359; Gm9125; Tdpoz9", "protein_names_uniprotkb": "TD and POZ domain-containing protein 1-like", "protein_names_refseq": "TD and POZ domain-containing protein 1-like", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:668359)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q717B3;Q71G58;Q8BZV7;Q8VI39", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0DMR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17125-1", "uniprot_id": "TGFB3_MOUSE", "mass": 46885.0, "length": 410, "protein_name": "Transforming growth factor beta-3 proprotein", "gene_name": "Tgfb3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tgfb3", "gene_names_refseq": "", "protein_names_uniprotkb": "Transforming growth factor beta-3 proprotein", "protein_names_refseq": "", "tax_id": 10090, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); Loeys-Dietz syndrome 5 (Disease Ontology:DOID:0070236); arrhythmogenic right ventricular dysplasia 1 (Disease Ontology:DOID:0110070); colon cancer (Disease Ontology:DOID:219); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); colorectal cancer (Disease Ontology:DOID:9256); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (R-MMU-114608); (R-MMU-2129379); (R-MMU-2173789)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10433915;19745830;2069871;2206556;2628730;28912269;34428180;7493021;7493022", "class_list": "", "function": "Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (PubMed:28912269). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively., [UniProtKB, UniProtKB, UniProtKB]; Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (PubMed:10433915, PubMed:28912269, PubMed:7493021, PubMed:7493022). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (PubMed:28912269). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034714 type III transforming growth factor beta receptor binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity;GO:0050431 transforming growth factor beta binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030141 secretory granule;GO:0031012 extracellular matrix;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050678 regulation of epithelial cell proliferation;GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P17125-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03404-1", "uniprot_id": "TFF2_MOUSE", "mass": 14172.0, "length": 129, "protein_name": "Trefoil factor 2", "gene_name": "Tff2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tff2; Sml1; Sp", "gene_names_refseq": "", "protein_names_uniprotkb": "Trefoil factor 2; SP; Spasmolytic polypeptide", "protein_names_refseq": "", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); myopia (Disease Ontology:DOID:11830)", "pathway": " (mmu:21785)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;2303034", "class_list": "", "function": "Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08913", "ec_number_list": "", "go_molecular_function": "GO:0031723 CXCR4 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0060455 negative regulation of gastric acid secretion;GO:0008284 positive regulation of cell population proliferation;GO:0019722 calcium-mediated signaling;GO:0070098 chemokine-mediated signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q03404-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q149S1-1", "uniprot_id": "TEKT4_MOUSE", "mass": 52045.0, "length": 447, "protein_name": "Tektin-4", "gene_name": "Tekt4", "organism": "Mouse", "refseq_name": "tektin-4 isoform 1", "refseq_ac": "NP_082227", "gene_names_uniprotkb": "Tekt4", "gene_names_refseq": "1700010L19Rik; Tekt4", "protein_names_uniprotkb": "Tektin-4; Testicular microtubules-related protein 4", "protein_names_refseq": "tektin-4 isoform 1; testicular microtubules-related protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:71840)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16596631;17244819;21750661;36206347;37295417;37865089;37989994", "class_list": "", "function": "Data suggest that Tektin 4 is not associated with axonemal tubulins but instead associated with Outer Dense Fibers in rodent spermatozoa., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; TEKT4 is necessary for the proper coordinated beating of the sperm flagellum and male reproductive physiology, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0R4J051;Q3ZTL6;Q9DAH3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0015630 microtubule cytoskeleton;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece;GO:0005879 axonemal microtubule", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0060378 regulation of brood size;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q149S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14AT2-1", "uniprot_id": "TEX11_MOUSE", "mass": 109624.0, "length": 947, "protein_name": "Testis-expressed protein 11", "gene_name": "Tex11", "organism": "Mouse", "refseq_name": "testis-expressed protein 11 isoform 2", "refseq_ac": "NP_001161469", "gene_names_uniprotkb": "Tex11; Zip4", "gene_names_refseq": "4930565P14Rik; Tex11; ZIP4H", "protein_names_uniprotkb": "Testis-expressed protein 11; Protein ZIP4 homolog; ZIP4H", "protein_names_refseq": "protein ZIP4 homolog; testis-expressed protein 11 isoform 2; testis-expressed protein 11; testis-expressed sequence 11 protein", "tax_id": 10090, "disease": "X-linked spermatogenic failure 2 (Disease Ontology:DOID:0070185)", "pathway": " (mmu:83558)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11279525;18316482;18369460;22383461;30272023;30746471;37612290;39231187", "class_list": "", "function": "A partial deletion within the meiosis-specific sporulation domain SPO22 of Tex11 is not associated with infertility in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers., [UniProtKB, PubMed, PubMed]; TEX11 promotes initiation and/or maintenance of synapsis and formation of crossovers, and may provide a physical link between these two meiotic processes. GeneRIF: Tex11 forms discrete foci on meiotic chromosomes. Tex11 is essential for meiosis and fertility in males. Tex11 promotes both chromosomal synapsis and crossover formation in mice and may link these two meiotic processes by interacting with Sycp2 in vivo., [RefSeq, PubMed]; Tex11 was first identified from mouse spermatogonia and was specifically expressed in mouse testis., [RefSeq, PubMed]; Zip4h (Tex11), a male germ cell specific X-linked gene was isolated. Zip4h(-/Y) mutant mice were fertile. Analysis of spermatocytes revealed a delay in meiotic double strand break repair and decreased crossover formation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUS0;Q99MW9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000801 central element;GO:0000794 condensed nuclear chromosome;GO:0005694 chromosome", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0007060 male meiosis chromosome segregation;GO:0009566 fertilization;GO:0043066 negative regulation of apoptotic process;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q14AT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DP50-1", "uniprot_id": "TEX24_MOUSE", "mass": 38993.0, "length": 351, "protein_name": "Protein Tex24", "gene_name": "Tex24", "organism": "Mouse", "refseq_name": "protein Tex24", "refseq_ac": "NP_001013627", "gene_names_uniprotkb": "Tex24; TESF-1", "gene_names_refseq": "1700108N07Rik; TESF-1; Tex24", "protein_names_uniprotkb": "Protein Tex24; Testis-expressed protein 24; Testis-specific factor 1", "protein_names_refseq": "protein Tex24; testis-expressed protein 24; testis-specific factor 1; testis-specific protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:541463)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16343427;31599954", "class_list": "", "function": "Nuclear factor which might have a role in spermatogenesis., [UniProtKB, PubMed]; Taken together, these results indicate that TESF-1 is a novel male germ cell-specific gene, and its protein product may function as a nuclear factor involved in the regulation of spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0008024 cyclin/CDK positive transcription elongation factor complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032786 positive regulation of DNA-templated transcription, elongation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5DP50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62313-1", "uniprot_id": "TGON1_MOUSE", "mass": 37848.0, "length": 353, "protein_name": "Trans-Golgi network integral membrane protein 1", "gene_name": "Tgoln1", "organism": "Mouse", "refseq_name": "trans-Golgi network integral membrane protein 1 precursor", "refseq_ac": "NP_033469", "gene_names_uniprotkb": "Tgoln1; Ttgn1", "gene_names_refseq": "D6Ertd384e; TGN38A; TGN38; Tgoln1; Ttgn1", "protein_names_uniprotkb": "Trans-Golgi network integral membrane protein 1; TGN38A", "protein_names_refseq": "trans-Golgi network integral membrane protein 1 precursor; trans-Golgi network integral membrane protein 1; trans-golgi network protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22134); (R-MMU-381426); (R-MMU-432722); (R-MMU-6811440); (R-MMU-8856825); (R-MMU-8856828); (R-MMU-8957275)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;19144319;19349973;25486359;30899004;33725478;34428180;35984892;7540170", "class_list": "", "function": "May be involved in regulating membrane traffic to and from trans-Golgi network., [UniProtKB]; TGN38 may regulate the metaphase I/anaphase I transition and asymmetric cell division in mouse oocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q62313-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6YCH2-1", "uniprot_id": "TDPZ4_MOUSE", "mass": 42196.0, "length": 370, "protein_name": "TD and POZ domain-containing protein 4", "gene_name": "Tdpoz4", "organism": "Mouse", "refseq_name": "TD and POZ domain-containing protein 4", "refseq_ac": "NP_997155", "gene_names_uniprotkb": "Tdpoz4", "gene_names_refseq": "Tdpoz4", "protein_names_uniprotkb": "TD and POZ domain-containing protein 4", "protein_names_refseq": "TD and POZ domain-containing protein 4", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:399675)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14693377", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QJY8;Q14BT0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6YCH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q717B4-1", "uniprot_id": "TDPZ3_MOUSE", "mass": 41521.0, "length": 365, "protein_name": "TD and POZ domain-containing protein 3", "gene_name": "Tdpoz3", "organism": "Mouse", "refseq_name": "TD and POZ domain-containing protein 3", "refseq_ac": "NP_997154", "gene_names_uniprotkb": "Tdpoz3", "gene_names_refseq": "Tdpoz3", "protein_names_uniprotkb": "TD and POZ domain-containing protein 3", "protein_names_refseq": "TD and POZ domain containing gene 3; TD and POZ domain-containing protein 3", "tax_id": 10090, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:399674)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14693377", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QKH5", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q717B4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZ33-1", "uniprot_id": "TENS4_MOUSE", "mass": 74622.0, "length": 696, "protein_name": "Tensin-4", "gene_name": "Tns4", "organism": "Mouse", "refseq_name": "tensin-4 precursor", "refseq_ac": "NP_766152", "gene_names_uniprotkb": "Tns4", "gene_names_refseq": "9930017A07Rik; Cten; Tns4", "protein_names_uniprotkb": "Tensin-4", "protein_names_refseq": "tensin-4 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:217169); (R-MMU-8875513)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "25428506;32567731;33768568;34428180", "class_list": "", "function": "A Mouse Model of Cholangiocarcinoma Uncovers a Role for Tensin-4 in Tumor Progression., [RefSeq, PubMed]; Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration. Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF. Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration., [UniProtKB, UniProtKB]; Tensin4 (TNS4) is upregulated by Wnt signalling in adenomas in multiple intestinal neoplasia (Min) mice., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2A552;Q3TCM8;Q7TNR5", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005925 focal adhesion", "go_biological_process": "GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BZ33-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K2X8-1", "uniprot_id": "TF2H5_MOUSE", "mass": 8037.0, "length": 71, "protein_name": "General transcription factor IIH subunit 5", "gene_name": "Gtf2h5", "organism": "Mouse", "refseq_name": "general transcription factor IIH subunit 5", "refseq_ac": "NP_852057", "gene_names_uniprotkb": "Gtf2h5; D17Wsu155e", "gene_names_refseq": "2700017P07Rik; 2810432H05Rik; D17Wsu155e; Gtf2h5", "protein_names_uniprotkb": "General transcription factor IIH subunit 5; General transcription factor IIH polypeptide 5; TFB5 ortholog; TFIIH basal transcription factor complex TTD-A subunit; TFIIH subunit p8", "protein_names_refseq": "TFB5 ortholog; TFIIH basal transcription factor complex TTD-A subunit; TFIIH subunit p8; general transcription factor IIH subunit 5", "tax_id": 10090, "disease": "trichothiodystrophy (Disease Ontology:DOID:0111866); photosensitive trichothiodystrophy 3 (Disease Ontology:DOID:0111871)", "pathway": " (mmu:66467); (R-MMU-112382); (R-MMU-113418); (R-MMU-5696395); (R-MMU-5696400); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-72086); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075)", "pathway_count": 20, "publication_count": 11, "publication_id_list": "17525332;19224205;20173027;25428506;25605945;27802388;28888655;30779550;31599954;34428180;35820727", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BT75", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005675 transcription factor TFIIH holo complex;GO:0005669 transcription factor TFIID complex;GO:0000439 transcription factor TFIIH core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006294 nucleotide-excision repair, preincision complex assembly;GO:0006362 transcription elongation by RNA polymerase I;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K2X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2M2-1", "uniprot_id": "TDIF2_MOUSE", "mass": 84277.0, "length": 758, "protein_name": "Deoxynucleotidyltransferase terminal-interacting protein 2", "gene_name": "Dnttip2", "organism": "Mouse", "refseq_name": "deoxynucleotidyltransferase terminal-interacting protein 2", "refseq_ac": "NP_722501", "gene_names_uniprotkb": "Dnttip2", "gene_names_refseq": "4930588M11Rik; Dnttip2; HSU15552", "protein_names_uniprotkb": "Deoxynucleotidyltransferase terminal-interacting protein 2", "protein_names_refseq": "acidic 82 kDa protein mRNA; deoxynucleotidyltransferase terminal-interacting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:99480)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19144319;21183079;25153642;28135057;28528544;30084848;31219806;34428180;34887587;36852467", "class_list": "", "function": "Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQW8;Q3UX19", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006396 RNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8R2M2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R2T8-1", "uniprot_id": "TF3C5_MOUSE", "mass": 60502.0, "length": 520, "protein_name": "General transcription factor 3C polypeptide 5", "gene_name": "Gtf3c5", "organism": "Mouse", "refseq_name": "general transcription factor 3C polypeptide 5 isoform a", "refseq_ac": "NP_001277413", "gene_names_uniprotkb": "Gtf3c5", "gene_names_refseq": "2700084A09Rik; Gtf3c5; TFIIIC63; TFiiiC2-63", "protein_names_uniprotkb": "General transcription factor 3C polypeptide 5; TF3C-epsilon; TFIIIC 63 kDa subunit; TFIIIC63; Transcription factor IIIC 63 kDa subunit; Transcription factor IIIC subunit epsilon", "protein_names_refseq": "TF3C-epsilon; TFIIIC 63 kDa subunit; TFIIICepsilon; general transcription factor 3C polypeptide 5 isoform a; general transcription factor 3C polypeptide 5; general transcription factor III polypeptide 5; transcription factor IIIC 63 kDa subunit; transcription factor IIIC subunit epsilon", "tax_id": 10090, "disease": "", "pathway": " (mmu:70239); (R-MMU-76061); (R-MMU-76066)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21750661;25428506;30084848;30779550;31219806;34428180", "class_list": "", "function": "Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLE3;Q8R0D0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000995 RNA polymerase III general transcription initiation factor activity", "go_cellular_component": "GO:0000127 transcription factor TFIIIC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0042791 5S class rRNA transcription by RNA polymerase III;GO:0035914 skeletal muscle cell differentiation;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R2T8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCH0-1", "uniprot_id": "THIKB_MOUSE", "mass": 43995.0, "length": 424, "protein_name": "3-ketoacyl-CoA thiolase B, peroxisomal", "gene_name": "Acaa1b", "organism": "Mouse", "refseq_name": "3-ketoacyl-CoA thiolase B, peroxisomal isoform 1 precursor", "refseq_ac": "NP_666342", "gene_names_uniprotkb": "Acaa1b; Acaa1", "gene_names_refseq": "Acaa1b", "protein_names_uniprotkb": "3-ketoacyl-CoA thiolase B, peroxisomal; 2.3.1.155; 2.3.1.16; 2.3.1.9; Acetyl-CoA acyltransferase B; Beta-ketothiolase B; Peroxisomal 3-oxoacyl-CoA thiolase B", "protein_names_refseq": "3-ketoacyl-CoA thiolase B, peroxisomal isoform 1 precursor; 3-ketoacyl-CoA thiolase B, peroxisomal; acetyl-CoA acyltransferase B; beta-ketothiolase B; peroxisomal 3-oxoacyl-CoA thiolase B", "tax_id": 10090, "disease": "", "pathway": " (mmu:235674); (R-MMU-2046106); (R-MMU-390247); (R-MMU-6798695); (R-MMU-9033241)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15043762;15589695;21352884;23576753;34428180;37453647", "class_list": "", "function": "Acetyl-Coenzyme A acyltransferase 1B is involved in the regulation of genes encoding cholesterol biosynthesis enzymes in the liver, [RefSeq, PubMed]; Molecular cloning, gene structure and tissue distribution of 3-ketoacyl-CoA thiolase B. Publication Status: Online-Only, [RefSeq, PubMed]; Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) (Probable). Plays an important role in fatty acid peroxisomal beta-oxidation (Probable). Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs (By similarity)., [UniProtKB, UniProtKB, PubMed]; The region of the peroxisomal 3-ketoacyl-CoA thiolase B gene encoding the catalytic site was disrupted by homologous recombination in order to analyze the phenotype of these thiolase B-deficient mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;1.14.11.18;3.2.1.18;3.4.24.34;3.4.21.-;3.2.1.17;3.4.23.5;3.1.3.48;2.3.1.176;2.3.1.16;2.3.1.155;2.3.2.36;3.6.5.2;3.4.21.37;3.5.3.1;3.2.1.166;1.8.3.2;3.1.2.-;3.1.2.2;3.1.2.1;2.3.1.9;2.5.1.26;1.4.3.22;1.4.3.-;2.7.1.35;3.6.1.6;2.7.10.2;2.3.2.5;3.1.21.-;3.2.1.14;3.5.1.3;3.4.18.1;3.4.19.9", "go_molecular_function": "GO:0003988 acetyl-CoA C-acyltransferase activity;GO:0003985 acetyl-CoA C-acetyltransferase activity;GO:0008775 acetate CoA-transferase activity;GO:0050633 acetyl-CoA C-myristoyltransferase activity;GO:0120524 long-chain fatty acyl-CoA oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0010124 phenylacetate catabolic process;GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0036109 alpha-linolenic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8VCH0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAJ2-1", "uniprot_id": "TEKT1_MOUSE", "mass": 48641.0, "length": 418, "protein_name": "Tektin-1", "gene_name": "Tekt1", "organism": "Mouse", "refseq_name": "tektin-1", "refseq_ac": "NP_001268935", "gene_names_uniprotkb": "Tekt1", "gene_names_refseq": "MT14; Tekt1", "protein_names_uniprotkb": "Tektin-1", "protein_names_refseq": "tektin-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:21689)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17971504;36206347;37295417;37865089;37989994", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme (PubMed:37295417, PubMed:37865089, PubMed:37989994). Forms filamentous polymers in the walls of ciliary and flagellar microtubules (PubMed:37295417)., [UniProtKB, PubMed, PubMed, PubMed]; Tekt1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0036126 sperm flagellum;GO:0005879 axonemal microtubule;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DAJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJD0-1", "uniprot_id": "THA11_MOUSE", "mass": 33276.0, "length": 305, "protein_name": "THAP domain-containing protein 11", "gene_name": "Thap11", "organism": "Mouse", "refseq_name": "THAP domain-containing protein 11", "refseq_ac": "NP_067488", "gene_names_uniprotkb": "Thap11; MNCb-2032", "gene_names_refseq": "2810036E22Rik; CTG-B43a; CTG-B45d; Ronin; Thap11", "protein_names_uniprotkb": "THAP domain-containing protein 11; Ronin", "protein_names_refseq": "THAP domain-containing protein 11", "tax_id": 10090, "disease": "methylmalonic aciduria and homocystinuria type cblC (Disease Ontology:DOID:0050715)", "pathway": " (mmu:59016)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18585351;20581084;26876175;28715716;29117561;34165550;34515391;35013307", "class_list": "", "function": "Findings identify Ronin as an essential factor underlying embryogenesis and ES cell pluripotency; its association with HCF-1 suggests an epigenetic mechanism of gene repression in pluripotent cells. Erratum:[Cell. 2008 Aug 22;134(4):692], [RefSeq, PubMed]; Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Ronin binds to and regulates the genes encoding several DNA repair factors, including Gtf2h4 and Rad18, providing a potential mechanism for this phenotype., [RefSeq, PubMed]; Ronin overexpression induces cerebellar degeneration in a mouse model of ataxia., [RefSeq, PubMed]; Ronin/Hcf-1 controls a genetic program that contributes to the unimpeded growth of embryonic stem cells., [RefSeq, PubMed]; The activity of Ronin coincided with the recruitment of its cofactor, Hcf-1, and the elevation of H3K4me3 levels at specific target genes, suggesting the involvement of an epigenetic mechanism., [RefSeq, PubMed]; Transcription factor, which has both transcriptional activation and repression activities (PubMed:18585351, PubMed:26876175, PubMed:34515391). Also modulates chromatin accessibility (By similarity). In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (By similarity). May regulate the expression of genes that encode both cytoplasmic and mitochondrial ribosomal proteins (PubMed:34515391). Required for normal mitochondrial development and function. Regulates mitochondrial gene expression, including that of components of the electron transport chain (PubMed:26876175, PubMed:34515391). Involved in the maintainance of pluripotency in early embryonic cells, possibly through its action on mitochondrial maturation which is required to meet high energy demands of these cells (PubMed:18585351, PubMed:34515391). Required for early development of retina, preventing premature exit of retinal progenitor cells from the cell cycle. This effect may also be mediated by its action on mitochondria (PubMed:26876175). Through the regulation of MMACHC gene expression, controls cobalamin metabolism (By similarity). Required for normal brain development and neural precursor differentiation (By similarity). Involved in cell growth (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (PubMed:18585351). Required for normal brain development and neural precursor differentiation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCZ5;Q99KZ0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JJD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9QYM9-1", "uniprot_id": "TEFF2_MOUSE", "mass": 41415.0, "length": 374, "protein_name": "Tomoregulin-2", "gene_name": "Tmeff2", "organism": "Mouse", "refseq_name": "tomoregulin-2 precursor", "refseq_ac": "NP_062764", "gene_names_uniprotkb": "Tmeff2; MNCb-1026", "gene_names_refseq": "4832418D20Rik; 7630402F16Rik; TR-2; Tmeff2", "protein_names_uniprotkb": "Tomoregulin-2; TR-2; Transmembrane protein with EGF-like and two follistatin-like domains", "protein_names_refseq": "tomoregulin-2 precursor; tomoregulin-2", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054)", "pathway": " (mmu:56363)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10600548;10903839;21750661;24632071;26402097;28336932", "class_list": "", "function": "Loss of TMEFF2 is associated with cell migration and invasion leading to prostate cancer., [RefSeq, PubMed]; May be a survival factor for hippocampal and mesencephalic neurons. The shedded form may up-regulate cell proliferation (By similarity)., [UniProtKB, UniProtKB]; Results suggest that TMEFF2 is a brain-enriched endogenous modulator of Abeta neurotoxicity and an enhancer of alpha-secretase processing of AbetaPP, [RefSeq, PubMed]; Together, these data suggested that Tmeff2 is specifically upregulated in oligodendrocytes, but dispensable for oligodendrocyte differentiation and maturation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UY20;Q8CDH1;Q9JJE3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0030336 negative regulation of cell migration;GO:0045720 negative regulation of integrin biosynthetic process;GO:0051497 negative regulation of stress fiber assembly;GO:0044319 wound healing, spreading of cells", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QYM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1J1-1", "uniprot_id": "TF7L1_MOUSE", "mass": 62298.0, "length": 584, "protein_name": "Transcription factor 7-like 1", "gene_name": "Tcf7l1", "organism": "Mouse", "refseq_name": "transcription factor 7-like 1 isoform 2", "refseq_ac": "NP_033358", "gene_names_uniprotkb": "Tcf7l1; Tcf3", "gene_names_refseq": "Tcf-3; Tcf3; Tcf7l1; bHLHb21", "protein_names_uniprotkb": "Transcription factor 7-like 1; HMG box transcription factor 3; TCF-3; mTCF-3", "protein_names_refseq": "HMG box transcription factor 3; T-cell factor 3; transcription factor 7-like 1 isoform 2; transcription factor 7-like 2 (T-cell specific, HMG box)", "tax_id": 10090, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:21415); (R-MMU-201722); (R-MMU-3769402); (R-MMU-4641265); (R-MMU-8951430); (R-MMU-9825892)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "10498690;11445543;21750661;24129315;25428506;30779550;34428180;37296573;38639717;9488439", "class_list": "", "function": "Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis., [UniProtKB, PubMed]; TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small Intestine. Publication Status: Online-Only, [RefSeq, PubMed]; Tbl1 promotes Wnt-beta-catenin signaling-induced degradation of the Tcf7l1 protein in mouse embryonic stem cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70450;O70573", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z1J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DID7-1", "uniprot_id": "WLS_MOUSE", "mass": 62188.0, "length": 541, "protein_name": "Protein wntless homolog", "gene_name": "Wls", "organism": "Mouse", "refseq_name": "protein wntless homolog isoform 1", "refseq_ac": "NP_080858", "gene_names_uniprotkb": "Wls; Gpr177", "gene_names_refseq": "5031439A09Rik; EVI; Gpr177; Wls", "protein_names_uniprotkb": "Protein wntless homolog; EVI; Integral membrane protein GPR177; Protein evenness interrupted homolog", "protein_names_refseq": "G protein-coupled receptor 177; integral membrane protein GPR177; protein evenness interrupted homolog; protein wntless homolog isoform 1; wntless homolog", "tax_id": 10090, "disease": "Zaki syndrome (Disease Ontology:DOID:0070473)", "pathway": " (mmu:68151); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "19841259;20214800;20652957;21750661;31219806;34428180;34587386", "class_list": "", "function": "A reciprocal regulation of Wnt and Gpr177 is essential for the patterning of the anterior-posterior axis during mammalian development., [RefSeq, PubMed]; Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Also plays an important role in establishment of the anterior-posterior body axis formation during development., [UniProtKB, PubMed]; These findings suggest a previously unrecognized role for GPR177 in regulating cellular response to opioid agonist drugs, and could create new avenues of investigation regarding the pharmacotherapy of drug dependence. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CE42;Q9D2B7", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0017147 Wnt-protein binding;GO:0031852 mu-type opioid receptor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0030902 hindbrain development;GO:0016055 Wnt signaling pathway;GO:0050775 positive regulation of dendrite morphogenesis;GO:0001707 mesoderm formation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6DID7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3J5-1", "uniprot_id": "ZN131_MOUSE", "mass": 71022.0, "length": 619, "protein_name": "Zinc finger protein 131", "gene_name": "Zfp131; Znf131", "organism": "Mouse", "refseq_name": "zinc finger protein 131 isoform 1", "refseq_ac": "NP_001289476", "gene_names_uniprotkb": "Zfp131; Znf131; Zfp131", "gene_names_refseq": "2610109I01Rik; Zbtb35; Zfp131; Znf131", "protein_names_uniprotkb": "Zinc finger protein 131", "protein_names_refseq": "putative transcription factor ZNF131; zinc finger protein 131 isoform 1; zinc finger protein 131", "tax_id": 10090, "disease": "", "pathway": " (mmu:72465); (R-MMU-3899300)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12163020;17306895;20303951;21183079;21750661;26136427;28882591;29750959;35294876;38341068", "class_list": "", "function": "May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling (By similarity). Plays a role during development and organogenesis as well as in the function of the adult central nervous system., [UniProtKB, PubMed]; Results suggest that Znf131/ZNF131 plays a role during development and organogenesis as well as in the function of the adult central nervous system., [RefSeq, PubMed]; The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes., [RefSeq, PubMed]; The mechanism of Znf131 nuclear localization, is reported., [RefSeq, PubMed]; This gene encodes a member of the BTB/POZ family of transcription factors. This protein has been found to act as a transcriptional activator and may regulate estrogen receptor signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]., [RefSeq]; We also demonstrate that Kaiso inhibits Znf131 expression, raising the possibility that Kaiso and Znf131 act to fine-tune target gene expression. Together, our findings implicate Znf131 as a co-regulator of Kaiso-mediated biological processes., [RefSeq, PubMed]; YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1., [RefSeq, PubMed]; ZNF131 suppresses expression of Cdk inhibitor, p21(cip1), and that of pro-apoptotic factors, Bax and Puma, targets of p53, to facilitate cell cycle progression and suppress unnecessary apoptosis, respectively, of pro-B cells., [RefSeq, PubMed]; Znf131 is a transcriptional activator, a less common function of POZ-ZF proteins, that is negatively regulated by its heterodimerization partner Kaiso., [RefSeq, PubMed]; Znf131 is critical for T cell development during double-negative to double-positive stage, with which significant cell expansion triggered by the pre-TCR signal is coupled., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYZ4;Q80UU7;Q8C8D0;Q9D042", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0045111 intermediate filament cytoskeleton;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K3J5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56280-1", "uniprot_id": "TCL1A_MOUSE", "mass": 14112.0, "length": 116, "protein_name": "T-cell leukemia/lymphoma protein 1A", "gene_name": "Tcl1a; Tcl1", "organism": "Mouse", "refseq_name": "T-cell leukemia/lymphoma protein 1A isoform 1", "refseq_ac": "NP_033363", "gene_names_uniprotkb": "Tcl1a; Tcl1; Tcl1", "gene_names_refseq": "Tcl1a; Tcl1", "protein_names_uniprotkb": "T-cell leukemia/lymphoma protein 1A; Oncogene TCL-1; Oncogene TCL1; Protein p14 TCL1", "protein_names_refseq": "T-cell leukemia/lymphoma protein 1A isoform 1; T-cell leukemia/lymphoma protein 1A; TCL-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1", "tax_id": 10090, "disease": "T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (mmu:21432)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10716693;11679718;12011454;21750661;34206229;36179280;37023372;37046083;39198400;9285687", "class_list": "", "function": "Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis., [RefSeq, PubMed]; B-cell intrinsic RANK signaling cooperates with TCL1 to induce lineage-dependent B-cell transformation. Publication Status: Online-Only, [RefSeq, PubMed]; Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (By similarity)., [UniProtKB]; Evidence for Non-Cancer-Specific T Cell Exhaustion in the Tcl1 Mouse Model for Chronic Lymphocytic Leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia., [RefSeq, PubMed]; TCL1 and/or other genes in the TCL1 pathway are responsible for the initiation of human chronic lymphocytic leukemia., [RefSeq, PubMed]; The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0032148 activation of protein kinase B activity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P56280-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A286YCV9-1", "uniprot_id": "A0A286YCV9_MOUSE", "mass": 204942.0, "length": 1847, "protein_name": "Kinesin family member 13B", "gene_name": "Kif13b", "organism": "Mouse", "refseq_name": "kinesin-like protein KIF13B isoform X1", "refseq_ac": "XP_006518682", "gene_names_uniprotkb": "Kif13b", "gene_names_refseq": "5330429L19Rik; 6030414C01; C130021D12Rik; GAKIN; Kif13b", "protein_names_uniprotkb": "Kinesin family member 13B", "protein_names_refseq": "kinesin-like protein KIF13B isoform X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:16554); (R-MMU-6811434); (R-MMU-983189)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;17242355;19144319;21750661;27642159;28528544", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity;GO:0019901 protein kinase binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0030424 axon;GO:0005871 kinesin complex", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0050770 regulation of axonogenesis;GO:0045184 establishment of protein localization;GO:0047496 vesicle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A286YCV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C6G8-1", "uniprot_id": "WDR26_MOUSE", "mass": 70543.0, "length": 641, "protein_name": "WD repeat-containing protein 26", "gene_name": "Wdr26", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 26 isoform 1", "refseq_ac": "NP_663489", "gene_names_uniprotkb": "Wdr26", "gene_names_refseq": "1600024A01Rik; Gid7; Wdr26", "protein_names_uniprotkb": "WD repeat-containing protein 26", "protein_names_refseq": "WD repeat-containing protein 26 isoform 1; WD repeat-containing protein 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:226757); (R-MMU-9861718)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21183079;21750661;22065575;26740625;34428180;34678516;34876184", "class_list": "", "function": "G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (By similarity). Also protects cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; WDR26 and MTF2 are therapeutic targets in multiple myeloma. Publication Status: Online-Only, [RefSeq, PubMed]; WDR26 is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9PX83;Q3TK81;Q8C4F3;Q8VDZ6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C6G8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C7L0-1", "uniprot_id": "WIPF3_MOUSE", "mass": 49453.0, "length": 485, "protein_name": "WAS/WASL-interacting protein family member 3", "gene_name": "Wipf3", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Wipf3; Cr16", "gene_names_refseq": "", "protein_names_uniprotkb": "WAS/WASL-interacting protein family member 3; Corticosteroids and regional expression protein 16 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:330319); (R-MMU-2029482); (R-MMU-5663213)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;17573773;21183079;21750661;24129315", "class_list": "", "function": "May be a regulator of cytoskeletal organization (Potential). May have a role in spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0045202 synapse;GO:0055037 recycling endosome;GO:0071203 WASH complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0042147 retrograde transport, endosome to Golgi;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P0C7L0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V0C1-1", "uniprot_id": "ZMAT1_MOUSE", "mass": 84176.0, "length": 714, "protein_name": "Zinc finger matrin-type protein 1", "gene_name": "Zmat1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zmat1; Kiaa1789", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger matrin-type protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:215693)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;28011936;28135057", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AFB3;Q5DTV1;Q8BI78", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3V0C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88286-1", "uniprot_id": "WIZ_MOUSE", "mass": 184291.0, "length": 1684, "protein_name": "Protein Wiz", "gene_name": "Wiz", "organism": "Mouse", "refseq_name": "protein Wiz isoform 2", "refseq_ac": "NP_035847", "gene_names_uniprotkb": "Wiz", "gene_names_refseq": "Wiz", "protein_names_uniprotkb": "Protein Wiz; Widely-interspaced zinc finger-containing protein", "protein_names_refseq": "protein Wiz isoform 2; protein Wiz; widely-interspaced zinc finger-containing protein", "tax_id": 10090, "disease": "atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (mmu:22404)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12226707;16702210;17242355;21183079;21750661;21913724;22872234;25428506;27410475;33649389;34887587;9795207", "class_list": "", "function": "Chromatin immunoprecipitation-DNA sequence analysis was performed in adult cerebellum and Wiz peaks were found at promoters and transcription factor CTCF binding sites. Publication Status: Online-Only, [RefSeq, PubMed]; May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Wiz plays a major role in G9a/GLP heterodimer formation in cultured stem cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O88287;Q1XG03;Q3UZX7;Q7TSJ4;Q9CT89", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990226 histone methyltransferase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030496 midbody", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0050821 protein stabilization;GO:0010571 positive regulation of nuclear cell cycle DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O88286-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00417-1", "uniprot_id": "TCF7_MOUSE", "mass": 45465.0, "length": 419, "protein_name": "Transcription factor 7", "gene_name": "Tcf7", "organism": "Mouse", "refseq_name": "transcription factor 7 isoform 2", "refseq_ac": "NP_033357", "gene_names_uniprotkb": "Tcf7; Tcf-1; Tcf1", "gene_names_refseq": "TCF-1; Tcf1; Tcf7", "protein_names_uniprotkb": "Transcription factor 7; T-cell factor 1; T-cell-specific transcription factor 1; TCF-7", "protein_names_refseq": "T-cell-specific transcription factor 1; transcription factor 7 isoform 2", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:21414); (R-MMU-201722); (R-MMU-3769402); (R-MMU-4641265); (R-MMU-8951430); (R-MMU-9825892)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10489374;11477404;17218525;1827138;21750661;23562159;27713059;30084848;30413363;35820727;8622675", "class_list": "", "function": "This gene encodes a transcription factor which is a member of the T-cell specific transcription factor family. The encoded protein is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]., [RefSeq]; Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (PubMed:17218525). Inhibits the developmental program of IL17A effector gamma-delta T-cell subsets via regulating the transcription of T-cell lineage effector proteins (PubMed:23562159, PubMed:30413363). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (PubMed:23562159). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1 (By similarity). May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0000791 euchromatin", "go_biological_process": "GO:0048619 embryonic hindgut morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q00417-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CCG1-1", "uniprot_id": "ZC21C_MOUSE", "mass": 59642.0, "length": 527, "protein_name": "Zinc finger C2HC domain-containing protein 1C", "gene_name": "Zc2hc1c", "organism": "Mouse", "refseq_name": "zinc finger C2HC domain-containing protein 1C", "refseq_ac": "NP_766002", "gene_names_uniprotkb": "Zc2hc1c; Fam164c", "gene_names_refseq": "2810002I04Rik; Fam164c; Zc2hc1c", "protein_names_uniprotkb": "Zinc finger C2HC domain-containing protein 1C", "protein_names_refseq": "family with sequence similarity 164, member C; protein FAM164C; zinc finger C2HC domain-containing protein 1C", "tax_id": 10090, "disease": "", "pathway": " (mmu:72350)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCM8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CCG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1W2P7J1-1", "uniprot_id": "A0A1W2P7J1_MOUSE", "mass": 27944.0, "length": 249, "protein_name": "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial", "gene_name": "Coq10a", "organism": "Mouse", "refseq_name": "coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform 2", "refseq_ac": "NP_001361629", "gene_names_uniprotkb": "Coq10a", "gene_names_refseq": "Coq10a; Gm1", "protein_names_uniprotkb": "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial", "protein_names_refseq": "coenzyme Q-binding protein COQ10 homolog A, mitochondrial isoform 2; coenzyme Q10 homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:210582); (R-MMU-611105); (R-MMU-9864848)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21750661;25552930", "class_list": "", "function": "Coenzyme Q10 protects astrocytes from ROS-induced damage through inhibition of mitochondria-mediated cell death pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1W2P7J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R331-1", "uniprot_id": "ZNHI1_MOUSE", "mass": 17504.0, "length": 154, "protein_name": "Zinc finger HIT domain-containing protein 1", "gene_name": "Znhit1", "organism": "Mouse", "refseq_name": "zinc finger HIT domain-containing protein 1 isoform 2", "refseq_ac": "NP_001297676", "gene_names_uniprotkb": "Znhit1", "gene_names_refseq": "2700001K05Rik; ZNFN4A1; Znhit1", "protein_names_uniprotkb": "Zinc finger HIT domain-containing protein 1; p18 Hamlet", "protein_names_refseq": "p18 Hamlet; zinc finger HIT domain-containing protein 1 isoform 2; zinc finger HIT domain-containing protein 1; zinc finger protein, subfamily 4A (HIT domain containing), member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70103)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19501046;20473270;21750661;29138493;30842416;32694618;33913477;35167494;35413238;35472217;36115458", "class_list": "", "function": "Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching., [RefSeq, PubMed]; Plays a role in chromatin remodeling by promoting the incorporation of histone variant H2AZ1/H2A.Z into the genome to regulate gene expression (PubMed:29138493, PubMed:30842416, PubMed:32694618, PubMed:33913477, PubMed:35167494, PubMed:35413238). Promotes SRCAP complex-mediated deposition of histone variant H2AZ1 to lymphoid fate regulator genes, enhancing lymphoid lineage commitment (PubMed:29138493). Recruited to the promoter of the transcriptional activator MYOG at the early stages of muscle differentiation where it mediates binding of histone variant H2AZ1 to chromatin and induces muscle-specific gene expression (By similarity). Maintains hematopoietic stem cell (HSC) quiescence by determining the chromatin accessibility at distal enhancers of HSC quiescence genes such as PTEN, FSTL1 and KLF4, enhancing deposition of H2AZ1 to promote their sustained transcription and restricting PI3K-AKT signaling inhibition (PubMed:32694618). Plays a role in intestinal stem cell maintenance by promoting H2AZ1 deposition at the transcription start sites of genes involved in intestinal stem cell fate determination including LGR5, TGFB1 and TGFBR2, thereby contributing to gene transcription (PubMed:30842416). Promotes phosphorylation of the H2AZ1 chaperone VPS72/YL1 which enhances the interaction between HZAZ1 and VPS72 (PubMed:30842416). Regulates the entry of male germ cells into meiosis by controlling histone H2AZ1 deposition which facilitates the expression of meiotic genes such as MEIOSIN, leading to the initiation of meiosis (PubMed:35413238). Required for postnatal heart function through its role in maintenance of cardiac Ca(2+) homeostasis by modulating the expression of Ca(2+)-regulating proteins CASQ1 and ATP2A2/SERCA2A via deposition of histone H2AZ1 at their promoters (PubMed:35167494). During embryonic heart development, required for mitochondrial maturation and oxidative metabolism by functioning through H2AZ1 deposition to activate transcription of metabolic genes and is also required to maintain the stability of the respiratory complex (PubMed:33913477). In neural cells, increases deposition of the H2AZ1 histone variant and promotes neurite growth (By similarity). Plays a role in TP53/p53-mediated apoptosis induction by stimulating the transcriptional activation of several proapoptotic p53 target genes such as PMAIP1/NOXA and BBC3/PUMA (By similarity). Mediates cell cycle arrest induced in response to gamma-irradiation by enhancing recruitment of TP53/p53 to the promoter of the cell cycle inhibitor CDKN1A, leading to its transcriptional activation (By similarity). Recruited to the promoter of cyclin-dependent kinase CDK6 and inhibits its transcription, possibly by decreasing the acetylation level of histone H4, leading to cell cycle arrest at the G1 phase (PubMed:19501046). Plays a role in lens fiber cell differentiation by regulating the expression of cell cycle regulator CDKN1A/p21Cip1 (PubMed:35472217). Binds to transcriptional repressor NR1D2 and relieves it of its inhibitory effect on the transcription of apolipoprotein APOC3 without affecting its DNA-binding activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; These findings identified Znhit1 as a CDK6 regulator that plays an important role in cell proliferation., [RefSeq, PubMed]; These results identify SRCAP/H2A.Z-mediated chromatin remodelling as a key early event in muscle differentiation-specific gene expression., [RefSeq, PubMed]; Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation., [RefSeq, PubMed]; Znhit1 promotes the interaction between H2A.Z and YL1 (H2A.Z chaperone) by controlling YL1 phosphorylation. These results demonstrate that Znhit1/H2A.Z is essential for Lgr5+ stem cell maintenance and intestinal homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZS6", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0042393 histone binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000812 Swr1 complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0070317 negative regulation of G0 to G1 transition", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R331-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EQB9-1", "uniprot_id": "ZN287_MOUSE", "mass": 86635.0, "length": 759, "protein_name": "Zinc finger protein 287", "gene_name": "Zfp287; Znf287", "organism": "Mouse", "refseq_name": "zinc finger protein 287 isoform 1", "refseq_ac": "NP_573471", "gene_names_uniprotkb": "Zfp287; Znf287; Skat2; Zfp287", "gene_names_refseq": "B230333C16Rik; SKAT-2; Skat2; Zfp287; Znf287; mszf16; mszf74; zfp-287", "protein_names_uniprotkb": "Zinc finger protein 287; Zfp-287; Zinc finger protein SKAT-2", "protein_names_refseq": "zinc finger protein 287 isoform 1; zinc finger protein SKAT-2; zinc finger protein SKAT2", "tax_id": 10090, "disease": "", "pathway": " (mmu:170740)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11093124;21750661;25428506;30084848;34203471;34428180", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDU3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0051239 regulation of multicellular organismal process;GO:0009893 positive regulation of metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EQB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BI67-1", "uniprot_id": "ZN473_MOUSE", "mass": 101741.0, "length": 892, "protein_name": "Zinc finger protein 473 homolog", "gene_name": "Zfp473; Znf473", "organism": "Mouse", "refseq_name": "zinc finger protein 473 homolog isoform 1", "refseq_ac": "NP_001276765", "gene_names_uniprotkb": "Zfp473; Znf473; Zfp100; Zfp473", "gene_names_refseq": "D030014N22Rik; Zfp473; Znf473; zfp-100", "protein_names_uniprotkb": "Zinc finger protein 473 homolog; Zfp-100; Zinc finger protein 100", "protein_names_refseq": "zinc finger protein 100; zinc finger protein 473 homolog isoform 1; zinc finger protein 473 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:243963); (R-MMU-111367); (R-MMU-212436); (R-MMU-73856); (R-MMU-77588)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BI98;Q8BIB7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0015030 Cajal body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage;GO:0022603 regulation of anatomical structure morphogenesis;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BI67-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C827-1", "uniprot_id": "ZFP62_MOUSE", "mass": 104812.0, "length": 914, "protein_name": "Zinc finger protein 62", "gene_name": "Zfp62", "organism": "Mouse", "refseq_name": "zinc finger protein 62 isoform 2", "refseq_ac": "NP_001020017", "gene_names_uniprotkb": "Zfp62", "gene_names_refseq": "Zfp62", "protein_names_uniprotkb": "Zinc finger protein 62; ZT3; Zfp-62", "protein_names_refseq": "ZT3; zinc finger protein 62 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22720)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21183079;21750661;21952136;25428506;25605945;30084848;30779550;31219806;34428180;8808410", "class_list": "", "function": "May play a role in differentiating skeletal muscle., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3H0;Q62510;Q8BT00;Q8C2S6;Q8R5D1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C827-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3T9E4-1", "uniprot_id": "TGTP2_MOUSE", "mass": 47121.0, "length": 415, "protein_name": "T-cell-specific guanine nucleotide triphosphate-binding protein 2", "gene_name": "Tgtp1; Tgtp2", "organism": "Mouse", "refseq_name": "T-cell-specific guanine nucleotide triphosphate-binding protein 2", "refseq_ac": "NP_001138636", "gene_names_uniprotkb": "Tgtp1; Tgtp2; Ifggb6; Irgb6; Mg21; Tgtp", "gene_names_refseq": "100039796; TGTP; Tgtp2", "protein_names_uniprotkb": "T-cell-specific guanine nucleotide triphosphate-binding protein 2; 3.6.5.-; Interferon-gamma-inducible GTPase Ifggb6 protein; T-cell-specific guanine nucleotide triphosphate-binding protein", "protein_names_refseq": "Irgb6 homologue; T-cell-specific guanine nucleotide triphosphate-binding protein 2; interferon-gamma-inducible GTPase Ifggb6 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039796); (mmu:21822)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "16277747;19265156;19285957;20109161;21147463;21750661;22761577;22802726;22892676;24324375;24563254;24832449;34428180;7836757;7884320;9725230", "class_list": "", "function": "Involved in innate cell-autonomous resistance to intracellular pathogens, such as Toxoplasma gondii (PubMed:19265156, PubMed:20109161, PubMed:24563254, PubMed:21147463). During avirulent type II T.gondii infection, recruited to the parasitophorous vacuole (PV) membrane, leading to PV vesiculation and rupture, and subsequent digestion of the parasite within the cytosol (PubMed:19265156, PubMed:24563254, PubMed:24324375, PubMed:22802726, PubMed:21147463). Not recruited to virulent type I T.gondii PV membrane (PubMed:19265156). May confer an antiviral state for vesicular stomatitis virus (PubMed:9725230)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.-;3.6.5.2;3.6.5.3;3.6.1.5;3.6.5.4;3.6.5.5;3.6.1.-;3.6.1.15;2.7.11.1;3.6.-.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0020005 symbiont-containing vacuole membrane;GO:0016020 membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0045087 innate immune response;GO:0009615 response to virus;GO:0035458 cellular response to interferon-beta;GO:0042832 defense response to protozoan", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q3T9E4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CBE3-1", "uniprot_id": "WDR37_MOUSE", "mass": 55046.0, "length": 496, "protein_name": "WD repeat-containing protein 37", "gene_name": "Wdr37", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 37 isoform a", "refseq_ac": "NP_001034477", "gene_names_uniprotkb": "Wdr37; Kiaa0982", "gene_names_refseq": "Wdr37", "protein_names_uniprotkb": "WD repeat-containing protein 37", "protein_names_refseq": "WD repeat-containing protein 37 isoform a; WD repeat-containing protein 37", "tax_id": 10090, "disease": "neurooculocardiogenitourinary syndrome (Disease Ontology:DOID:0111675)", "pathway": " (mmu:207615)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;22645316;31219806;33300544;33630350;34428180;36210013", "class_list": "", "function": "Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases., [RefSeq, PubMed]; Required for normal ER Ca2+ handling in lymphocytes. Together with PACS1, it plays an essential role in stabilizing peripheral lymphocyte populations., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y96;Q8CCL2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0022038 corpus callosum development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CBE3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q6C8-1", "uniprot_id": "XKR6_MOUSE", "mass": 70928.0, "length": 638, "protein_name": "XK-related protein 6", "gene_name": "Xkr6", "organism": "Mouse", "refseq_name": "XK-related protein 6", "refseq_ac": "NP_775569", "gene_names_uniprotkb": "Xkr6", "gene_names_refseq": "2700008G24Rik; Xkr6; Xrg6", "protein_names_uniprotkb": "XK-related protein 6", "protein_names_refseq": "X Kell blood group precursor related family member 6 homolog; XK-related protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:219149)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25231987;25428506", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3X9Y8;Q5GH65;Q8R1I8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0043652 engulfment of apoptotic cell;GO:0070782 phosphatidylserine exposure on apoptotic cell surface;GO:1902742 apoptotic process involved in development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q6C8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D270-1", "uniprot_id": "ZDH21_MOUSE", "mass": 31331.0, "length": 265, "protein_name": "Palmitoyltransferase ZDHHC21", "gene_name": "Zdhhc21", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC21", "refseq_ac": "NP_080923", "gene_names_uniprotkb": "Zdhhc21; Gramp3", "gene_names_refseq": "9130404H11Rik; D130004H04Rik; DHHC21; Zdhhc21; dep", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC21; 2.3.1.225; DHHC domain-containing cysteine-rich protein 21; DHHC21; GABA-A receptor-associated membrane protein 3; Zinc finger DHHC domain-containing protein 21", "protein_names_refseq": "DHHC domain-containing cysteine-rich protein 21; DHHC-21; GABA-A receptor-associated membrane protein 3; palmitoyltransferase ZDHHC21; probable palmitoyltransferase ZDHHC21; zinc finger DHHC domain-containing protein 21", "tax_id": 10090, "disease": "", "pathway": " (mmu:68268); (R-MMU-203615); (R-MMU-9009391)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15229235;19956733;21750661;26715683;27653213;28838985;32789573;34045489;34080635;34428180", "class_list": "", "function": "Ca2+-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells., [RefSeq, PubMed]; DHHC21 deficiency attenuates renal dysfunction during septic injury. Publication Status: Online-Only, [RefSeq, PubMed]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:19956733, PubMed:26715683, PubMed:27653213). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity). Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation (PubMed:19956733). Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium (PubMed:27653213). Also has a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction (PubMed:26715683). May also palmitoylate eNOS and LCK (PubMed:19956733)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Regulation of T cell receptor signaling by protein acyltransferase DHHC21., [RefSeq, PubMed]; Results suggest an important role of ZDHHC21 in mediating gut hyperpermeability resulting from thermal injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6EMK1;Q80XQ3", "ec_number_list": "2.3.1.225;6.3.1.2;2.3.1.-;1.14.13.39", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0048733 sebaceous gland development;GO:1903140 regulation of establishment of endothelial barrier;GO:0003056 regulation of vascular associated smooth muscle contraction;GO:0006612 protein targeting to membrane;GO:0071875 adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D270-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q7P1-1", "uniprot_id": "E9Q7P1_MOUSE", "mass": 159943.0, "length": 1613, "protein_name": "Collagen, type XXII, alpha 1", "gene_name": "Col22a1", "organism": "Mouse", "refseq_name": "collagen alpha-1(XXII) chain precursor", "refseq_ac": "NP_081450", "gene_names_uniprotkb": "Col22a1", "gene_names_refseq": "2310067L16Rik; Col22a1", "protein_names_uniprotkb": "Collagen, type XXII, alpha 1", "protein_names_refseq": "collagen alpha-1(XXII) chain precursor", "tax_id": 10090, "disease": "intracranial aneurysm (Disease Ontology:DOID:10941)", "pathway": " (mmu:69700); (R-MMU-1650814); (R-MMU-8948216)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:1990321 collagen type XXII trimer", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9Q7P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPK7-1", "uniprot_id": "XPO7_MOUSE", "mass": 123810.0, "length": 1087, "protein_name": "Exportin-7", "gene_name": "Xpo7", "organism": "Mouse", "refseq_name": "exportin-7 isoform 2", "refseq_ac": "NP_075532", "gene_names_uniprotkb": "Xpo7; Kiaa0745; Ranbp16", "gene_names_refseq": "4930506C02Rik; Ranbp16; Xpo7; exp7", "protein_names_uniprotkb": "Exportin-7; Exp7; Ran-binding protein 16", "protein_names_refseq": "RAN binding protein 16; exportin-7 isoform 2; ran-binding protein 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:65246)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11071879;21750661;25428506;30084848;30779550;33300544;33383157;34428180;35973480;37000263;38780091;39627609", "class_list": "", "function": "An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis., [RefSeq, PubMed]; Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3., [RefSeq, PubMed]; Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity)., [UniProtKB]; The GWAS SNP rs80207740 modulates erythrocyte traits via allele-specific binding of IKZF1 and targeting XPO7 gene., [RefSeq, PubMed]; Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP94;Q80TS9;Q8BSK5;Q8C9M7;Q8CB42;Q8CBL8;Q8CEF5", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005737 cytoplasm", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0006611 protein export from nucleus;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9EPK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10754-1", "uniprot_id": "RHIT_MOUSE", "mass": 56054.0, "length": 512, "protein_name": "Transcriptional repressor Rhit", "gene_name": "Zfp13", "organism": "Mouse", "refseq_name": "transcriptional repressor Rhit isoform 1", "refseq_ac": "NP_035877", "gene_names_uniprotkb": "Zfp13; Krox-8; Rhit; Zfp-13", "gene_names_refseq": "Krox-8; Zfp-13; Zfp13", "protein_names_uniprotkb": "Transcriptional repressor Rhit; Repressor of heat-inducible transcription; Zinc finger protein 13; Zinc finger protein Krox-8", "protein_names_refseq": "transcriptional repressor Rhit isoform 1; transcriptional repressor Rhit; zinc finger protein Krox-8", "tax_id": 10090, "disease": "", "pathway": " (mmu:22654); (R-MMU-212436)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20231359;21750661;2452975", "class_list": "", "function": "Data suggest that Rhit acts as a repressor in the heat-induced and age-dependent transcriptional regulation of the (S) isoform of Mpv17-like protein., [RefSeq, PubMed]; Transcriptional repressor that binds to the promoter region of Mpv17l isoform M-LP short and regulates its age-dependent and heat-induced expression (PubMed:20231359). By regulating Mpv17l expression, contributes to the regulation of genes involved in H(2)O(2) metabolism and the mitochondrial apoptotic cascade (By similarity) (PubMed:20231359)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D7F2B3;Q80WS0;Q8CDD0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0010729 positive regulation of hydrogen peroxide biosynthetic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P10754-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14AK4-1", "uniprot_id": "ZDH11_MOUSE", "mass": 39660.0, "length": 347, "protein_name": "Palmitoyltransferase ZDHHC11", "gene_name": "Zdhhc11", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC11", "refseq_ac": "NP_081980", "gene_names_uniprotkb": "Zdhhc11", "gene_names_refseq": "4933421L13Rik; DHHC-11; Zdhhc11; Zdhhc20", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC11; 2.3.1.225; DHHC-11; DHHC-containing protein 10; DHHC10(z11); Zinc finger DHHC domain-containing protein 11", "protein_names_refseq": "DHHC-containing protein 10; DHHC10(z11); palmitoyltransferase ZDHHC11; probable palmitoyltransferase ZDHHC11; zinc finger DHHC domain-containing protein 11; zinc finger, DHHC domain containing 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:71164)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23687301;29429998;35384384", "class_list": "", "function": "Also has a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response (PubMed:29429998). Functions as an adapter that recruits IRF3 to STING1 to promote the activation of that key transcriptional regulator of type I interferon (IFN)-dependent immune response (PubMed:29429998)., [UniProtKB, PubMed]; Endoplasmic reticulum-localized palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (PubMed:23687301). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (PubMed:23687301). May play a role in cell proliferation (By similarity)., [UniProtKB, UniProtKB, PubMed]; In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes., [RefSeq, PubMed]; Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5Y5T4", "ec_number_list": "2.3.1.225;6.3.1.2;2.3.1.-", "go_molecular_function": "GO:0035591 signaling adaptor activity;GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0010008 endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0002230 positive regulation of defense response to virus by host;GO:0018230 peptidyl-L-cysteine S-palmitoylation;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q14AK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1AQ89-1", "uniprot_id": "B1AQ89_MOUSE", "mass": 18414.0, "length": 175, "protein_name": "Keratin associated protein 4-24", "gene_name": "Krtap4-24", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Krtap4-24; Gm11555", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin associated protein 4-24", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-6805567)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "GO:0042633 hair cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1AQ89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K3G5-1", "uniprot_id": "VRK3_MOUSE", "mass": 50830.0, "length": 453, "protein_name": "Serine/threonine-protein kinase VRK3", "gene_name": "Vrk3", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase VRK3 isoform 1", "refseq_ac": "NP_598706", "gene_names_uniprotkb": "Vrk3", "gene_names_refseq": "Vrk3", "protein_names_uniprotkb": "Serine/threonine-protein kinase VRK3; 2.7.11.22; Vaccinia-related kinase 3", "protein_names_refseq": "inactive serine/threonine-protein kinase VRK3; serine/threonine-protein kinase VRK3 isoform 1; serine/threonine-protein kinase VRK3; serine/threonine-protein pseudokinase VRK3", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:101568); (R-MMU-202670)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11986327;12782311;14645249;16845380;17242355;21183079;21750661;25428506;27346674;28412365;31219806;34428180;39927985", "class_list": "", "function": "Finally, downregulation of hvrk3 using siRNA reduced the amplitude and lengthened the period of the cellular bioluminescence rhythm. Taken together, these data suggest that VRK3 plays a role in setting the amplitude and period length of circadian rhythms in mammalian cells., [RefSeq, PubMed]; Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis. Under normal physiological conditions, negatively regulates ERK activity along with VHR phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death. For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR phosphatase., [UniProtKB, UniProtKB, PubMed, PubMed]; Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation Publication Status: Online-Only, [RefSeq, PubMed]; VRK genes play a role during embryonic development of hematopoiesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921W6", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;3.1.3.16;3.1.3.48;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019903 protein phosphatase binding;GO:0072542 protein phosphatase activator activity;GO:0004693 cyclin-dependent protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0006974 DNA damage response;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K3G5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6H5-1", "uniprot_id": "ZDHC4_MOUSE", "mass": 39528.0, "length": 343, "protein_name": "Palmitoyltransferase ZDHHC4", "gene_name": "Zdhhc4", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC4 isoform 1", "refseq_ac": "NP_082655", "gene_names_uniprotkb": "Zdhhc4", "gene_names_refseq": "1810021D01Rik; 2900029I10Rik; DHHC-4; Zdhhc4", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC4; 2.3.1.225; DHHC-4; Zinc finger DHHC domain-containing protein 4", "protein_names_refseq": "palmitoyltransferase ZDHHC4 isoform 1; probable palmitoyltransferase ZDHHC4; zinc finger DHHC domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:72881)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates including the D(2) dopamine receptor DRD2, GSK3B or MAVS. Mediates GSK3B palmitoylation to prevent its AKT1-mediated phosphorylation leading to activation of the STAT3 signaling pathway. Also catalyzes MAVS palmitoylation which promotes its stabilization and activation by inhibiting 'Lys-48'- but facilitating 'Lys-63'-linked ubiquitination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R5E0", "ec_number_list": "2.3.1.225;6.3.1.2;2.3.1.-", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0072659 protein localization to plasma membrane;GO:0006612 protein targeting to membrane;GO:0030336 negative regulation of cell migration;GO:0045089 positive regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D6H5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O55047-1", "uniprot_id": "TLK2_MOUSE", "mass": 82261.0, "length": 718, "protein_name": "Serine/threonine-protein kinase tousled-like 2", "gene_name": "Tlk2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase tousled-like 2 isoform B", "refseq_ac": "NP_001281260", "gene_names_uniprotkb": "Tlk2; Tlk", "gene_names_refseq": "4933403M19Rik; PKU-alpha; PKUalpha; Tlk2; Tlk", "protein_names_uniprotkb": "Serine/threonine-protein kinase tousled-like 2; 2.7.11.1; PKU-alpha; Tousled-like kinase 2", "protein_names_refseq": "protein kinase U-alpha; serine/threonine-protein kinase tousled-like 2 isoform B; serine/threonine-protein kinase tousled-like 2", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 57 (Disease Ontology:DOID:0061031)", "pathway": " (mmu:24086)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10092119;10455159;10523312;21750661;28708136;34428180", "class_list": "", "function": "Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (By similarity). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (By similarity). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (By similarity). Negative regulator of amino acid starvation-induced autophagy (By similarity)., [UniProtKB, UniProtKB]; TLK1 and TLK2 have largely redundant roles in genome maintenance., [RefSeq, PubMed]; Testis-specific isoforms may play a role in spermatogenesis. Highly expressed in embryos throughout development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ASU7;B1ASU8;Q9D5Y5", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005882 intermediate filament;GO:0005730 nucleolus", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007059 chromosome segregation;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O55047-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D2J4-1", "uniprot_id": "VSIG1_MOUSE", "mass": 44015.0, "length": 407, "protein_name": "V-set and immunoglobulin domain-containing protein 1", "gene_name": "Vsig1", "organism": "Mouse", "refseq_name": "V-set and immunoglobulin domain-containing protein 1 isoform 2", "refseq_ac": "NP_080379", "gene_names_uniprotkb": "Vsig1; Gpa34", "gene_names_refseq": "1700062D20Rik; 4930405J24Rik; Vsig1", "protein_names_uniprotkb": "V-set and immunoglobulin domain-containing protein 1; Cell surface A33 antigen; Glycoprotein A34", "protein_names_refseq": "V-set and immunoglobulin domain-containing protein 1 isoform 2; V-set and immunoglobulin domain-containing protein 1; cell surface A33 antigen; glycoprotein A34", "tax_id": 10090, "disease": "", "pathway": " (mmu:78789)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16405301;20957455;21183079;21750661;21991385;33176137;34428180", "class_list": "", "function": "Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and Restricted by VSIG1., [RefSeq, PubMed]; Mouse VSIG1 interacts with Sertoli cells by heterophilic adhesion via its first Ig-like domain, [RefSeq, PubMed]; VSIG1 is required for the establishment of glandular versus squamous epithelia in the stomach., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9J0;Q9DA22", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0030277 maintenance of gastrointestinal epithelium;GO:0003382 epithelial cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D2J4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTW4-1", "uniprot_id": "TFEC_MOUSE", "mass": 35144.0, "length": 317, "protein_name": "Transcription factor EC", "gene_name": "Tfec", "organism": "Mouse", "refseq_name": "transcription factor EC", "refseq_ac": "NP_112475", "gene_names_uniprotkb": "Tfec; Tcfec", "gene_names_refseq": "Tcfec; Tfec; bHLHe34", "protein_names_uniprotkb": "Transcription factor EC; TFE-C; mTFEC", "protein_names_refseq": "TFE-C; mTFEC; transcription factor EC", "tax_id": 10090, "disease": "lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (mmu:21426)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10036191;11818452;15459106;15908341;21750661;28238747;7958932;9973413", "class_list": "", "function": "Tfec transcribes IL-4 receptor alpha expression to promote M2 programming in macrophages Erratum:[J Allergy Clin Immunol. 2022 Aug;150(2):491. doi: 10.1016/j.jaci.2022.05.013. PMID: 35934683], [RefSeq, PubMed]; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence) (By similarity). Binds to element F in an E-box sequence-specific manner (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWR7", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WTW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPL0-1", "uniprot_id": "XYLT2_MOUSE", "mass": 96811.0, "length": 865, "protein_name": "Xylosyltransferase 2", "gene_name": "Xylt2", "organism": "Mouse", "refseq_name": "xylosyltransferase 2", "refseq_ac": "NP_665827", "gene_names_uniprotkb": "Xylt2", "gene_names_refseq": "E030002B02Rik; XT-II; XT2; Xylt2; xylT-II", "protein_names_uniprotkb": "Xylosyltransferase 2; 2.4.2.26; Peptide O-xylosyltransferase 2; Xylosyltransferase II", "protein_names_refseq": "peptide O-xylosyltransferase 2; xylosyltransferase 2", "tax_id": 10090, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); pseudoxanthoma elasticum (Disease Ontology:DOID:2738)", "pathway": " (mmu:217119); (R-MMU-1971475)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17189265;17517600;19389916;21750661;25428506;30084848;30778123;30779550;32965647;34428180", "class_list": "glycogene;glycosyltransferase", "function": "Alterations in proteoglycans (PGs)concentrations can occur due to loss of XylT2, and that reduced PGs can induce cyst development, [RefSeq, PubMed]; Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN (PubMed:17517600). Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; The data from Xylt2 knock-out mice and mice with liver neoplasia show that liver is a significant source of serum XylT2 activity., [RefSeq, PubMed]; Using a xylosyltransferase II (Xylt2) deficient mouse model, studied the role of extracellular matrix sulfated glycosaminoglycans in adipose tissue and metabolic homeostasis., [RefSeq, PubMed]; Xylosyltransferase 2 deficiency and organ homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 26, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5SUY1;Q8K060", "ec_number_list": "2.4.2.26", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0030158 protein xylosyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005576 extracellular region", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0030210 heparin proteoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9EPL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESJ0-1", "uniprot_id": "XPO4_MOUSE", "mass": 129979.0, "length": 1151, "protein_name": "Exportin-4", "gene_name": "Xpo4", "organism": "Mouse", "refseq_name": "exportin-4 isoform 1", "refseq_ac": "NP_065252", "gene_names_uniprotkb": "Xpo4; Kiaa1721", "gene_names_refseq": "B430309A01Rik; Xpo4; mKIAA1721", "protein_names_uniprotkb": "Exportin-4; Exp4", "protein_names_refseq": "exp4; exportin-4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:57258)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10944119;19349578;21183079;21750661;22872234;27306458;30084848;31219806;34418053;34428180;36182935;38722973;39627609", "class_list": "", "function": "Exp4 (exportin 4) is an interaction partner of Sox2 in mouse embryonic stem cells and neural progenitors., [RefSeq, PubMed]; Exportin 4 DNA promoter methylation in liver fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2) (By similarity). In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form (By similarity). Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins (By similarity). Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor (By similarity). XPO4 then return to the nuclear compartment and mediate another round of transport (By similarity). The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Catalyzes the nuclear export of hypusinated EIF5A; a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4 (PubMed:27306458). Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6 (By similarity). Also mediates the nuclear import of SOX transcription factors SRY and SOX2 (PubMed:19349578)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QLH3;Q6ZPJ4", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046827 positive regulation of protein export from nucleus;GO:0006096 glycolytic process;GO:0006611 protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9ESJ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14BV6-1", "uniprot_id": "YDJC_MOUSE", "mass": 33094.0, "length": 310, "protein_name": "Carbohydrate deacetylase", "gene_name": "Ydjc", "organism": "Mouse", "refseq_name": "carbohydrate deacetylase isoform 1", "refseq_ac": "NP_081216", "gene_names_uniprotkb": "Ydjc", "gene_names_refseq": "1810015A11Rik; 4930521M19Rik; Ydjc", "protein_names_uniprotkb": "Carbohydrate deacetylase; 3.5.1.-", "protein_names_refseq": "UPF0249 protein ydjC homolog; carbohydrate deacetylase isoform 1; carbohydrate deacetylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:69101)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806", "class_list": "", "function": "Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5Z5;Q9D8Z7", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0016787 hydrolase activity;GO:0019213 deacetylase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q14BV6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00519-1", "uniprot_id": "XDH_MOUSE", "mass": 146562.0, "length": 1335, "protein_name": "Xanthine dehydrogenase/oxidase", "gene_name": "Xdh", "organism": "Mouse", "refseq_name": "xanthine dehydrogenase/oxidase", "refseq_ac": "NP_035853", "gene_names_uniprotkb": "Xdh", "gene_names_refseq": "XO; Xdh; Xor; Xox-1; Xox1", "protein_names_uniprotkb": "Xanthine dehydrogenase/oxidase; XOR; Xanthine oxidoreductase", "protein_names_refseq": "xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); renal fibrosis (Disease Ontology:DOID:0050855); xanthinuria (Disease Ontology:DOID:0060236); xanthinuria type I (Disease Ontology:DOID:0070452); muscular disease (Disease Ontology:DOID:0080000); interstitial nephritis (Disease Ontology:DOID:1063); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); cardiovascular system disease (Disease Ontology:DOID:1287); cholestasis (Disease Ontology:DOID:13580); Lesch-Nyhan syndrome (Disease Ontology:DOID:1919); hyperuricemia (Disease Ontology:DOID:1920); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); acute kidney failure (Disease Ontology:DOID:3021); carotid artery disease (Disease Ontology:DOID:3407); pancreatitis (Disease Ontology:DOID:4989); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); peritonitis (Disease Ontology:DOID:8283); cataract (Disease Ontology:DOID:83); multiple myeloma (Disease Ontology:DOID:9538); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:22436); (R-MMU-74259); (R-MMU-8851680); (R-MMU-9748787)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "12502743;15878860;1590774;21540332;21750661;25153642;25428506;26495903;28135057;31219806;34428180;39927985;7835888;8541302", "class_list": "", "function": "Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species., [UniProtKB, UniProtKB]; Mouse Xdh is a moonlighting protein that has two distinct catalytic activities and acts a structural protein in milk fat droplets., [RefSeq, PubMed]; Rat Xdh is a moonlighting protein that has two distinct catalytic activities as a dehydrogenase and an oxidase., [RefSeq, PubMed]; This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein exists as two distinct enzymatic forms, either as xanthine dehydrogenase, or as xanthine oxidase, and functions in purine degradation. Additional studies also suggest a role in adipogenesis, and a function as a structural protein in milk fat droplets in the lactating mammary gland. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLM9", "ec_number_list": "1.17.1.4;1.17.3.2", "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006154 adenosine catabolic process;GO:0006157 deoxyadenosine catabolic process;GO:0006196 AMP catabolic process;GO:0007595 lactation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q00519-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K0D7-1", "uniprot_id": "GET1_MOUSE", "mass": 19867.0, "length": 174, "protein_name": "Guided entry of tail-anchored proteins factor 1", "gene_name": "Get1", "organism": "Mouse", "refseq_name": "guided entry of tail-anchored proteins factor 1", "refseq_ac": "NP_997184", "gene_names_uniprotkb": "Get1; Wrb", "gene_names_refseq": "5530402J05Rik; C030018G21Rik; Chd5; Get1; Wrb", "protein_names_uniprotkb": "Guided entry of tail-anchored proteins factor 1; Tail-anchored protein insertion receptor WRB; Tryptophan-rich basic protein", "protein_names_refseq": "guided entry of tail-anchored proteins factor 1; tail-anchored protein insertion receptor WRB; tryptophan rich basic protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71446)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;28000760", "class_list": "", "function": "Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG., [UniProtKB, UniProtKB]; Stx5 is an autophagy target that is inefficiently membrane-targeted by alternative pathways; mice without WRB have different biogenesis requirements for tail anchored proteins Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA55;Q9D1W0", "ec_number_list": "", "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0043529 GET complex", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0045048 protein insertion into ER membrane;GO:0001964 startle response;GO:0050808 synapse organization;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K0D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U1J1-1", "uniprot_id": "TFPT_MOUSE", "mass": 28954.0, "length": 259, "protein_name": "TCF3 fusion partner homolog", "gene_name": "Tfpt", "organism": "Mouse", "refseq_name": "TCF3 fusion partner homolog isoform 1", "refseq_ac": "NP_001277310", "gene_names_uniprotkb": "Tfpt; Amida", "gene_names_refseq": "2400004F01Rik; Amida; FB1; Tfpt", "protein_names_uniprotkb": "TCF3 fusion partner homolog; Protein FB1; Protein amida", "protein_names_refseq": "TCF3 fusion partner homolog isoform 1; TCF3 fusion partner homolog; protein amida", "tax_id": 10090, "disease": "", "pathway": " (mmu:69714); (R-MMU-5689603); (R-MMU-5696394)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17041757;21183079;21750661;36852467", "class_list": "", "function": "Although p53 is a main regulator of apoptosis in mammalian cells, the Tfpt induced apoptosis appears p53-independent., [RefSeq, PubMed]; Appears to promote apoptosis in a p53/TP53-independent manner., [UniProtKB]; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9EP77", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0019901 protein kinase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0031011 Ino80 complex", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3U1J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17141-1", "uniprot_id": "ZFP37_MOUSE", "mass": 67226.0, "length": 594, "protein_name": "Zinc finger protein 37", "gene_name": "Zfp37", "organism": "Mouse", "refseq_name": "zinc finger protein 37 isoform 1", "refseq_ac": "NP_001277279", "gene_names_uniprotkb": "Zfp37; Zfp-37", "gene_names_refseq": "Tzn; Zfp-37; Zfp37", "protein_names_uniprotkb": "Zinc finger protein 37; Male germ cell-specific zinc finger protein; Zfp-37", "protein_names_refseq": "male germ cell-specific zinc finger protein; zinc finger protein 37 homolog; zinc finger protein 37 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22696); (R-MMU-212436)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1614869;2114017;21750661;29187734;8660973", "class_list": "", "function": "May have a role in regulating spermiogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62514;Q80YX7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0007281 germ cell development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P17141-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAI4-1", "uniprot_id": "ZBT43_MOUSE", "mass": 52652.0, "length": 467, "protein_name": "Zinc finger and BTB domain-containing protein 43", "gene_name": "Zbtb43", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 43 isoform b", "refseq_ac": "NP_001020765", "gene_names_uniprotkb": "Zbtb43; Kiaa0414; Zfp297b; Znf297b", "gene_names_refseq": "1700010E06Rik; Zbtb43; Zfp297b; mKIAA0414", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 43; Zinc finger protein 297B", "protein_names_refseq": "ortholog of zinc finger protein 297B ZNF297B; zinc finger and BTB domain-containing protein 43 isoform b; zinc finger and BTB domain-containing protein 43; zinc finger protein 297B", "tax_id": 10090, "disease": "", "pathway": " (mmu:71834)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001025 RNA polymerase III general transcription initiation factor binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DAI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54819-1", "uniprot_id": "TFPI1_MOUSE", "mass": 34987.0, "length": 306, "protein_name": "Tissue factor pathway inhibitor", "gene_name": "Tfpi", "organism": "Mouse", "refseq_name": "tissue factor pathway inhibitor isoform a precursor", "refseq_ac": "NP_035706", "gene_names_uniprotkb": "Tfpi", "gene_names_refseq": "A630013F22Rik; EPI; LACI; Tfpi", "protein_names_uniprotkb": "Tissue factor pathway inhibitor; EPI; Extrinsic pathway inhibitor; LACI; Lipoprotein-associated coagulation inhibitor; TFPI", "protein_names_refseq": "extrinsic pathway inhibitor; lipoprotein-associated coagulation inhibitor; tissue factor pathway inhibitor isoform a precursor", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); atrial fibrillation (Disease Ontology:DOID:0060224); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); graft-versus-host disease (Disease Ontology:DOID:0081267); preterm premature rupture of the membranes (Disease Ontology:DOID:0111144); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); disseminated intravascular coagulation (Disease Ontology:DOID:11247); familial hyperlipidemia (Disease Ontology:DOID:1168); nephrotic syndrome (Disease Ontology:DOID:1184); factor VIII deficiency (Disease Ontology:DOID:12134); leukemia (Disease Ontology:DOID:1240); toxic shock syndrome (Disease Ontology:DOID:14115); disease of cellular proliferation (Disease Ontology:DOID:14566); factor V deficiency (Disease Ontology:DOID:2216); transient cerebral ischemia (Disease Ontology:DOID:224); protein S deficiency (Disease Ontology:DOID:2451); pulmonary fibrosis (Disease Ontology:DOID:3770); liver cirrhosis (Disease Ontology:DOID:5082); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); myocardial infarction (Disease Ontology:DOID:5844); systemic lupus erythematosus (Disease Ontology:DOID:9074); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (mmu:21788); (R-MMU-9769735); (R-MMU-9769739)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;36696221;37030150;9493581;9974373", "class_list": "", "function": "Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation., [RefSeq, PubMed]; Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Platelet tissue factor pathway inhibitor-alpha dampens cardiac thrombosis and associated fibrosis in mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 24, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z2U8", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005901 caveola;GO:0005576 extracellular region", "go_biological_process": "GO:0007596 blood coagulation;GO:0030195 negative regulation of blood coagulation;GO:0071383 cellular response to steroid hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O54819-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U3V8-1", "uniprot_id": "XRRA1_MOUSE", "mass": 88884.0, "length": 786, "protein_name": "X-ray radiation resistance-associated protein 1", "gene_name": "Xrra1", "organism": "Mouse", "refseq_name": "X-ray radiation resistance-associated protein 1", "refseq_ac": "NP_001157730", "gene_names_uniprotkb": "Xrra1", "gene_names_refseq": "Xrra1", "protein_names_uniprotkb": "X-ray radiation resistance-associated protein 1", "protein_names_refseq": "X-ray radiation resistance-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:446101)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12908878;21750661", "class_list": "", "function": "May be involved in the response of cells to X-ray radiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RX67;Q7M740", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0010165 response to X-ray", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3U3V8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0I6-1", "uniprot_id": "WSDU1_MOUSE", "mass": 51691.0, "length": 474, "protein_name": "WD repeat, SAM and U-box domain-containing protein 1", "gene_name": "Wdsub1", "organism": "Mouse", "refseq_name": "WD repeat, SAM and U-box domain-containing protein 1 isoform 2", "refseq_ac": "NP_001153108", "gene_names_uniprotkb": "Wdsub1", "gene_names_refseq": "1700048E19Rik; 2610014F08Rik; Wdsub1", "protein_names_uniprotkb": "WD repeat, SAM and U-box domain-containing protein 1", "protein_names_refseq": "WD repeat, SAM and U-box domain-containing protein 1 isoform 2; WD repeat, SAM and U-box domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72137)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;37066759", "class_list": "", "function": "Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80X63", "ec_number_list": "", "go_molecular_function": "GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D0I6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R099-1", "uniprot_id": "TBL2_MOUSE", "mass": 49584.0, "length": 442, "protein_name": "Transducin beta-like protein 2", "gene_name": "Tbl2", "organism": "Mouse", "refseq_name": "transducin beta-like protein 2 isoform 1", "refseq_ac": "NP_038791", "gene_names_uniprotkb": "Tbl2", "gene_names_refseq": "Tbl2; WS-bTRP", "protein_names_uniprotkb": "Transducin beta-like protein 2", "protein_names_refseq": "transducin beta-like protein 2 isoform 1; transducin beta-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:27368)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10575226;21750661;37453647", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFY0", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051219 phosphoprotein binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0071456 cellular response to hypoxia;GO:0042149 cellular response to glucose starvation;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9R099-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHB4-1", "uniprot_id": "WDR31_MOUSE", "mass": 40530.0, "length": 367, "protein_name": "WD repeat-containing protein 31", "gene_name": "Wdr31", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 31 isoform 1", "refseq_ac": "NP_001277450", "gene_names_uniprotkb": "Wdr31", "gene_names_refseq": "5430402I10Rik; Wdr31; spWD", "protein_names_uniprotkb": "WD repeat-containing protein 31; Spermatid WD repeat-containing protein; spWD", "protein_names_refseq": "WD repeat-containing protein 31 isoform 1; WD repeat-containing protein 31; spermatid WD repeat-containing protein; spermatid WD-repeat protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:71354)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3URZ0;Q9D3N4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JHB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CIZ8-1", "uniprot_id": "VWF_MOUSE", "mass": 309269.0, "length": 2813, "protein_name": "von Willebrand factor", "gene_name": "Vwf", "organism": "Mouse", "refseq_name": "von Willebrand factor precursor", "refseq_ac": "NP_035838", "gene_names_uniprotkb": "Vwf", "gene_names_refseq": "6820430P06Rik; B130011O06Rik; C630030D09; F8VWF; VWD; Vwf", "protein_names_uniprotkb": "von Willebrand factor; vWF; von Willebrand antigen II", "protein_names_refseq": "Von Willebrand factor homolog; von Willebrand factor precursor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); atrial fibrillation (Disease Ontology:DOID:0060224); von Willebrand's disease 1 (Disease Ontology:DOID:0060573); von Willebrand's disease 2 (Disease Ontology:DOID:0060574); thrombosis (Disease Ontology:DOID:0060903); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); von Willebrand's disease 3 (Disease Ontology:DOID:0111054); osteonecrosis (Disease Ontology:DOID:10159); hypertension (Disease Ontology:DOID:10763); intracranial aneurysm (Disease Ontology:DOID:10941); alcoholic hepatitis (Disease Ontology:DOID:12351); von Willebrand's disease (Disease Ontology:DOID:12531); endomyocardial fibrosis (Disease Ontology:DOID:12932); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); Behcet's disease (Disease Ontology:DOID:13241); familial combined hyperlipidemia (Disease Ontology:DOID:13809); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574); aortic valve stenosis (Disease Ontology:DOID:1712); Bernard-Soulier syndrome (Disease Ontology:DOID:2217); essential thrombocythemia (Disease Ontology:DOID:2224); transient cerebral ischemia (Disease Ontology:DOID:224); bipolar disorder (Disease Ontology:DOID:3312); carotid artery disease (Disease Ontology:DOID:3407); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); renal cell carcinoma (Disease Ontology:DOID:4450); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); alcoholic pancreatitis (Disease Ontology:DOID:4988); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:22371); (R-MMU-114608); (R-MMU-216083); (R-MMU-354192); (R-MMU-354194); (R-MMU-372708); (R-MMU-430116); (R-MMU-5674135); (R-MMU-76009); (R-MMU-9769735); (R-MMU-9769739); (R-MMU-9769743)", "pathway_count": 12, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;10722222;10930441;12871266;14613933;15665869;20173027;21750661;22616016;22645316;23970904;25428506;26495903;26740625;29187734;30084848;33725478;34428180;8193357", "class_list": "", "function": "Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 17, "predicted_n_glycosites": 12, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 0, "mined_o_glycosites": 3, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 39, "glyco_site_count": 24, "binding_glycan_count": 0, "secondary_ac_list": "Q60863;Q6XUV6;Q8BIU9;Q8CGN0;Q9JK16", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001889 liver development;GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0007596 blood coagulation;GO:0001890 placenta development", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q8CIZ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07230-1", "uniprot_id": "ZSCA2_MOUSE", "mass": 68714.0, "length": 614, "protein_name": "Zinc finger and SCAN domain-containing protein 2", "gene_name": "Zscan2", "organism": "Mouse", "refseq_name": "zinc finger and SCAN domain-containing protein 2 isoform 1", "refseq_ac": "NP_033579", "gene_names_uniprotkb": "Zscan2; Zfp-29; Zfp29", "gene_names_refseq": "Zfp-29; Zfp29; Zscan2", "protein_names_uniprotkb": "Zinc finger and SCAN domain-containing protein 2; Zfp-29; Zinc finger protein 29", "protein_names_refseq": "zinc finger and SCAN domain-containing protein 2 isoform 1; zinc finger and SCAN domain-containing protein 2; zinc finger protein 29", "tax_id": 10090, "disease": "", "pathway": " (mmu:22691)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1937051;21750661;39172905", "class_list": "", "function": "Differential lung gene expression identified Zscan2 and Bag6 as novel tissue repair players in an experimental COPD model. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q07230-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66JT0-1", "uniprot_id": "WEE2_MOUSE", "mass": 62343.0, "length": 555, "protein_name": "Wee1-like protein kinase 2", "gene_name": "Wee2", "organism": "Mouse", "refseq_name": "wee1-like protein kinase 2", "refseq_ac": "NP_958758", "gene_names_uniprotkb": "Wee2; Wee1b", "gene_names_refseq": "Gm1065; Wee1B; Wee2", "protein_names_uniprotkb": "Wee1-like protein kinase 2; 2.7.10.2; Wee1-like protein kinase 1B; Wee1B kinase; mWee1B", "protein_names_refseq": "mWee1B; wee1-like protein kinase 1B; wee1-like protein kinase 2; wee1B kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:381759)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11029659;16169490;20083600;21454751;21750661;23616086", "class_list": "", "function": "Findings demonstrate that exit from metaphase requires not only a proteolytic degradation of cyclin B but also the inhibitory phosphorylation of Cdc2 by Wee1B, [RefSeq, PubMed]; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation., [UniProtKB, PubMed, PubMed, PubMed]; Wee1B is a key maturation-promoting-factor inhibitory kinase in mouse oocytes, functions downstream of PKA, and is required for maintaining meiotic arrest., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4U4S4;Q7TPV9", "ec_number_list": "2.7.12.2;2.7.10.1;2.7.12.1;2.7.1.32;2.7.1.82;2.7.10.2;2.7.11.1;2.7.11.13;2.7.10.4;2.7.1.40;2.7.11.23", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007143 female meiotic nuclear division;GO:0042327 positive regulation of phosphorylation;GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:1900194 negative regulation of oocyte maturation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q66JT0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JME9-1", "uniprot_id": "VTM2B_MOUSE", "mass": 30160.0, "length": 285, "protein_name": "V-set and transmembrane domain-containing protein 2B", "gene_name": "Vstm2b", "organism": "Mouse", "refseq_name": "V-set and transmembrane domain-containing protein 2B isoform 1 precursor", "refseq_ac": "NP_067362", "gene_names_uniprotkb": "Vstm2b", "gene_names_refseq": "2900093B09Rik; Vstm2b", "protein_names_uniprotkb": "V-set and transmembrane domain-containing protein 2B", "protein_names_refseq": "V-set and transmembrane domain-containing protein 2B isoform 1 precursor; V-set and transmembrane domain-containing protein 2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:58188)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10679242;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEK5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JME9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5RJ54-1", "uniprot_id": "ZSC26_MOUSE", "mass": 53526.0, "length": 466, "protein_name": "Zinc finger and SCAN domain-containing protein 26", "gene_name": "Zscan26", "organism": "Mouse", "refseq_name": "zinc finger and SCAN domain-containing protein 26 isoform b", "refseq_ac": "NP_001013808", "gene_names_uniprotkb": "Zscan26; Zfp187; Znf187", "gene_names_refseq": "Zfp187; Znf187; Zscan26", "protein_names_uniprotkb": "Zinc finger and SCAN domain-containing protein 26; Zinc finger protein 187", "protein_names_refseq": "zinc finger and SCAN domain-containing protein 26 isoform b; zinc finger and SCAN domain-containing protein 26; zinc finger protein 187", "tax_id": 10090, "disease": "", "pathway": " (mmu:432731)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NVD7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5RJ54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BHB4-1", "uniprot_id": "WDR3_MOUSE", "mass": 105775.0, "length": 942, "protein_name": "WD repeat-containing protein 3", "gene_name": "Wdr3", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 3 isoform 1", "refseq_ac": "NP_780761", "gene_names_uniprotkb": "Wdr3", "gene_names_refseq": "D030020G18Rik; Wdr3", "protein_names_uniprotkb": "WD repeat-containing protein 3", "protein_names_refseq": "WD repeat-containing protein 3 isoform 1; WD repeat-containing protein 3", "tax_id": 10090, "disease": "papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (mmu:269470); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21183079;21750661;31219806;34428180;34887587;36210013;36463953;36905106", "class_list": "", "function": "Characterization of a WD-repeat family protein WDR3 in the brain of WDR3 hetero knockout mice., [RefSeq, PubMed]; Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]; WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030515 snoRNA binding", "go_cellular_component": "GO:0034388 Pwp2p-containing subcomplex of 90S preribosome;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031965 nuclear membrane;GO:0032040 small-subunit processome", "go_biological_process": "GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BHB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R151-1", "uniprot_id": "ZNFX1_MOUSE", "mass": 218828.0, "length": 1909, "protein_name": "NFX1-type zinc finger-containing protein 1", "gene_name": "Znfx1", "organism": "Mouse", "refseq_name": "NFX1-type zinc finger-containing protein 1 isoform a", "refseq_ac": "NP_001028368", "gene_names_uniprotkb": "Znfx1", "gene_names_refseq": "Astx3; Znfx1", "protein_names_uniprotkb": "NFX1-type zinc finger-containing protein 1; 2.3.2.27; 3.6.4.-; ATP- dependent RNA translocase ZNFX1; E3 ubiquitin-protein and -ssRNA ligase ZNFX1", "protein_names_refseq": "NFX1-type zinc finger-containing protein 1 isoform a; NFX1-type zinc finger-containing protein 1", "tax_id": 10090, "disease": "immunodeficiency 91 (Disease Ontology:DOID:0061061)", "pathway": " (mmu:98999)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22872234;31219806;31685995;34203471;34428180;35820727;36892175;38016036", "class_list": "", "function": "Mitochondria-localized ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS., [RefSeq, PubMed]; RNA-activated non-canonical E3 ubiquitin ligase required for cell survival during interferon (IFN) responses (PubMed:31685995). Functions as an ATP-dependent 5'-> 3' RNA translocase that selectively recognizes long single-stranded RNA (ssRNA) molecules (>100 nt) from viral or host origin during immune activation. Upon ssRNA binding, oligomerizes to assemble a split E3 active site in trans, involving the Z-RING domain that binds and activates E2-ubiquitin conjugates, such as UBE2D2, and the RZ catalytic domain that mediates ubiquitin transfer. Catalyzes hydroxyl ubiquitination of the 2'-OH of ssRNA ribose and auto-ubiquitination, generating mainly 'Lys-48'- and 'Lys-6'-linked polyubiquitin chains. Forms ubiquitin-coated RNA condensates and stress granules, thereby regulating RNA metabolism, limiting excessive immune signaling, and preventing IFN-induced cell death. Also required for immunity against some bacteria, such as mycobacteria (By similarity)., [UniProtKB, PubMed, UniProtKB]; ZNFX1 antisense RNA1 promotes antiviral innate immune responses via modulating ZNFX1 function., [RefSeq, PubMed]; ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNA. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2A5R3;Q3U016;Q3UD71;Q3UEZ0", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0004386 helicase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0010494 cytoplasmic stress granule;GO:0031380 nuclear RNA-directed RNA polymerase complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0042742 defense response to bacterium;GO:0002218 activation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8R151-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TVW5-1", "uniprot_id": "TCHP_MOUSE", "mass": 60642.0, "length": 497, "protein_name": "Trichoplein keratin filament-binding protein", "gene_name": "Tchp", "organism": "Mouse", "refseq_name": "trichoplein keratin filament-binding protein", "refseq_ac": "NP_084268", "gene_names_uniprotkb": "Tchp", "gene_names_refseq": "A930031F18Rik; Tchp", "protein_names_uniprotkb": "Trichoplein keratin filament-binding protein; Mitochondrial protein with oncostatic activity; Mitostatin; Protein TCHP", "protein_names_refseq": "mitochondrial protein with oncostatic activity; mitostatin; trichoplein keratin filament-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:77832)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15731013;21750661;26880200", "class_list": "", "function": "Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly., [RefSeq, PubMed]; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZV6;Q8C459;Q9CTP0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0006915 apoptotic process;GO:0030308 negative regulation of cell growth;GO:0030030 cell projection organization;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TVW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R3L2-1", "uniprot_id": "TCF25_MOUSE", "mass": 76685.0, "length": 676, "protein_name": "Ribosome quality control complex subunit TCF25", "gene_name": "Tcf25", "organism": "Mouse", "refseq_name": "ribosome quality control complex subunit TCF25 isoform a", "refseq_ac": "NP_001032966", "gene_names_uniprotkb": "Tcf25; D8Ertd325e; Nulp1", "gene_names_refseq": "1100001J13Rik; 1810041K11Rik; D8Ertd325e; Nulp1; Tcf25; mKIAA1049", "protein_names_uniprotkb": "Ribosome quality control complex subunit TCF25; Nuclear localized protein 1; TCF-25; Transcription factor 25", "protein_names_refseq": "nuclear localized protein 1; ribosome quality control complex subunit TCF25 isoform a; ribosome quality control complex subunit TCF25", "tax_id": 10090, "disease": "", "pathway": " (mmu:66855); (R-MMU-9954709)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;12107429;16452087;18068114;18250455;20173027;21750661;25428506;25428507;25605945;30084848;30779550;31219806;31599954;32805187;34428180;35820727;37828378", "class_list": "", "function": "Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (By similarity). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (By similarity). May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (By similarity). May play a role in cell death control (PubMed:18068114)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The complex expression pattern and unique protein sequence, including an acidic amino terminal and putative transcription activation domain, suggests that Nulp1 may have a distinct role in embryonic development of many organs, including the adult brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3THR8;Q3UBI7;Q3UD64;Q3UG75;Q80ZX3;Q8BR80;Q8C200;Q8C2M3;Q8C6B4;Q9CUW0;Q9ER19", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990112 RQC complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006351 DNA-templated transcription;GO:0061945 regulation of protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8R3L2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80X41-1", "uniprot_id": "VRK1_MOUSE", "mass": 49741.0, "length": 440, "protein_name": "Serine/threonine-protein kinase VRK1", "gene_name": "Vrk1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase VRK1 isoform b", "refseq_ac": "NP_001025014", "gene_names_uniprotkb": "Vrk1", "gene_names_refseq": "51PK; Gm40568; Gm46378; Vrk1", "protein_names_uniprotkb": "Serine/threonine-protein kinase VRK1; 2.7.11.1; Serine/threonine-protein kinase 51PK; Vaccinia-related kinase 1", "protein_names_refseq": "serine/threonine-protein kinase 51PK; serine/threonine-protein kinase VRK1 isoform b; serine/threonine-protein kinase VRK1", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 1A (Disease Ontology:DOID:0060265); autosomal recessive distal hereditary motor neuronopathy 10 (Disease Ontology:DOID:0081429)", "pathway": " (mmu:22367); (R-MMU-2980766); (R-MMU-2995383)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "12782311;14645249;14747564;21346188;21750661;25609612;31219806;31527692;31629252;32365420;33076429;34428180;34504951;38536553;9521809", "class_list": "", "function": "Can perform the functions of B1 kinase required for vaccinia virus genome replication, most likely due to overlapping specificity for cellular and/or viral substrates, [RefSeq, PubMed]; Ginsenoside Rg3 upregulate VRK1 expression and P53BP1 foci formation in response to DNA damage., [RefSeq, PubMed]; Serine/threonine kinase involved in the regulation of key cellular processes including the cell cycle, nuclear condensation, transcription regulation, and DNA damage response (PubMed:14645249, PubMed:33076429, PubMed:9521809). Controls chromatin organization and remodeling by mediating phosphorylation of histone H3 on 'Thr-4' and histone H2AX (H2aXT4ph) (By similarity). It also phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity (PubMed:33076429). Is involved in the regulation of cell cycle progression of neural progenitors, and is required for proper cortical neuronal migration (PubMed:25609612). Is involved in neurite elongation and branching in motor neurons, and has an essential role in Cajal bodies assembly, acting through COIL phosphorylation and the control of coilin degradation (By similarity). Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation (By similarity). Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm (By similarity). Phosphorylates TP53BP1 and p53/TP53 on 'Thr-18', preventing the interaction between p53/TP53 and MDM2 (By similarity). Phosphorylates ATF2 which activates its transcriptional activity (By similarity). Phosphorylates JUN (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; VRK genes play a role during embryonic development of hematopoiesis, [RefSeq, PubMed]; VRK1 promotes DNA-induced type I interferon production. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88635;O88636;Q8C2P7;Q91YH9", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.24;2.7.12.2;2.7.12.1;2.7.11.22;2.7.10.2;2.7.11.-;2.7.11.4;2.7.11.10;2.7.11.11;2.7.11.26;2.7.11.19;2.7.11.17;2.7.2.3;2.7.11.12;2.7.11.23;3.1.11.-;2.7.4.6;2.7.13.3;2.7.4.18;3.1.24.-;2.7.11.13;2.7.1.153;2.7.1.137;2.7.1.40;2.7.11.21;2.7.11.39;2.3.1.-;2.7.11.31;3.6.5.-;2.3.1.48;4.1.1.32;2.7.11.38;3.6.1.-;3.6.-.-;3.1.26.-;2.7.11.34;2.7.1.154;2.7.11.8;2.7.1.150", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0031175 neuron projection development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q80X41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BKX7-1", "uniprot_id": "ZN410_MOUSE", "mass": 52208.0, "length": 478, "protein_name": "Zinc finger protein 410", "gene_name": "Zfp410; Znf410", "organism": "Mouse", "refseq_name": "zinc finger protein 410 isoform 2", "refseq_ac": "NP_001239511", "gene_names_uniprotkb": "Zfp410; Znf410; Apa1; D12Ertd748e; Zfp410", "gene_names_refseq": "Apa1; D12Ertd748e; Zfp410; Znf410", "protein_names_uniprotkb": "Zinc finger protein 410; Another partner for ARF 1", "protein_names_refseq": "another partner for ARF 1; zinc finger protein 410 isoform 2; zinc finger protein APA-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:52708)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12370286;21750661;33859416", "class_list": "", "function": "Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416). Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416). May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (By similarity). May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (By similarity). However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWB3;Q8BZZ7;Q8R5L2;Q8VDL2", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BKX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K083-1", "uniprot_id": "ZN536_MOUSE", "mass": 141576.0, "length": 1302, "protein_name": "Zinc finger protein 536", "gene_name": "Zfp536; Znf536", "organism": "Mouse", "refseq_name": "zinc finger protein 536 isoform a", "refseq_ac": "NP_759017", "gene_names_uniprotkb": "Zfp536; Znf536; Kiaa0390; Zfp536", "gene_names_refseq": "9630010P11Rik; Zfp536; Znf536; mKIAA0390", "protein_names_uniprotkb": "Zinc finger protein 536", "protein_names_refseq": "zinc finger protein 536 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:243937)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17065439;19398580;21750661;29187734", "class_list": "", "function": "Results identify a novel zinc finger protein, ZNF536, that negatively regulates neuron differentiation, [RefSeq, PubMed]; Transcriptional repressor that negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription (PubMed:19398580). Binds and interrupts RARA from binding to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580). Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3' (By similarity)., [UniProtKB, UniProtKB, PubMed]; ZFP536 promotes the late phase of oligodendrocyte differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80U15", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K083-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O88291-1", "uniprot_id": "ZN326_MOUSE", "mass": 65225.0, "length": 580, "protein_name": "DBIRD complex subunit ZNF326", "gene_name": "Zfp326; Znf326", "organism": "Mouse", "refseq_name": "DBIRD complex subunit ZNF326", "refseq_ac": "NP_061229", "gene_names_uniprotkb": "Zfp326; Znf326; Zan75; Zfp326; Zird", "gene_names_refseq": "5730470H14Rik; ZAN75; Zfp326; Znf326", "protein_names_uniprotkb": "DBIRD complex subunit ZNF326; Zinc finger protein 326; Zinc finger protein interacting with mRNPs; Zinc finger protein-associated with nuclear matrix of 75 kDa", "protein_names_refseq": "DBIRD complex subunit ZNF326; zinc finger protein interacting with mRNPs; zinc finger protein-associated with nuclear matrix of 75 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:54367)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;10798446;21183079;21750661;22645316;22666313;24129315;25428506;28135057;28528544;30084848;31219806;34428180;9809746", "class_list": "", "function": "Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (By similarity). May also play a role in neuronal differentiation. Able to bind DNA and activate expression in vitro., [UniProtKB, PubMed]; Involvement of the Zfp326 and ZNF326 genes in antidepressant treatment response, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05DP5;Q3TRI9;Q3UJI3;Q8BSJ5;Q8K1X9;Q9CYG9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016363 nuclear matrix;GO:0044609 DBIRD complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing;GO:0032784 regulation of DNA-templated transcription elongation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O88291-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66JZ4-1", "uniprot_id": "TCAIM_MOUSE", "mass": 57402.0, "length": 499, "protein_name": "T-cell activation inhibitor, mitochondrial", "gene_name": "TCAIM; Tcaim", "organism": "Mouse", "refseq_name": "T-cell activation inhibitor, mitochondrial isoform 1", "refseq_ac": "NP_001013423", "gene_names_uniprotkb": "TCAIM; Tcaim; D9Ertd402e; Toag1", "gene_names_refseq": "D9Ertd402e; Gm1129; TOAG-1; Tcaim", "protein_names_uniprotkb": "T-cell activation inhibitor, mitochondrial; TOAG-1; Tolerance associated gene-1 protein", "protein_names_refseq": "T-cell activation inhibitor, mitochondrial isoform 1; tolerance associated gene-1 protein; tolerance-associated gene 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:382117)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;17456197;19684086;21750661;25428506;25750433;34428180;37507081", "class_list": "", "function": "Downregulation of TOAG-1 and alpha-1,2-mannosidase expression occurred in graft infiltrating cells and expression of both genes was also downregulated after T-cell activation in vitro., [RefSeq, PubMed]; May regulate T-cell apoptosis., [UniProtKB]; TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q66JZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O54927-1", "uniprot_id": "WSB1_MOUSE", "mass": 47065.0, "length": 421, "protein_name": "WD repeat and SOCS box-containing protein 1", "gene_name": "Wsb1", "organism": "Mouse", "refseq_name": "WD repeat and SOCS box-containing protein 1 isoform 1", "refseq_ac": "NP_062627", "gene_names_uniprotkb": "Wsb1", "gene_names_refseq": "1110056B13Rik; 2700038M07Rik; Wsb1", "protein_names_uniprotkb": "WD repeat and SOCS box-containing protein 1; WSB-1", "protein_names_refseq": "WD repeat and SOCS box-containing protein 1 isoform 1; WD repeat and SOCS box-containing protein 1; WD-40-repeat-containing protein with a SOCS box 1; WSB-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:78889); (R-MMU-8951664); (R-MMU-983168)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15965468;21750661;27958289;31219806;34428180;38325552;9419338", "class_list": "", "function": "Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation (By similarity)., [UniProtKB]; WSB1 is one of the key players of early oncogenic events through ATM degradation and destruction of the tumorigenesis barrier., [RefSeq, PubMed]; WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0097413 Lewy body", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000209 protein polyubiquitination;GO:0044314 protein K27-linked ubiquitination;GO:0140454 protein aggregate center assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O54927-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z1A9-1", "uniprot_id": "TBCD8_MOUSE", "mass": 130057.0, "length": 1134, "protein_name": "TBC1 domain family member 8", "gene_name": "Tbc1d8", "organism": "Mouse", "refseq_name": "TBC1 domain family member 8 isoform 1", "refseq_ac": "NP_061245", "gene_names_uniprotkb": "Tbc1d8; Hblp1; Vrp", "gene_names_refseq": "AD3; HBLP1; Tbc1d8; VRP", "protein_names_uniprotkb": "TBC1 domain family member 8; BUB2-like protein 1; Vascular Rab-GAP/TBC-containing protein", "protein_names_refseq": "BUB2-like protein 1; GRAM domain; TBC1 domain family member 8 isoform 1; vascular Rab-GAP/TBC-containing protein", "tax_id": 10090, "disease": "nephrotic syndrome type 20 (Disease Ontology:DOID:0070357)", "pathway": " (mmu:54610)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "May act as a GTPase-activating protein for Rab family protein(s)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRZ8;Q3URH3;Q3UU99;Q6P1G8", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0003008 system process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z1A9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91YM4-1", "uniprot_id": "FAKD4_MOUSE", "mass": 71513.0, "length": 630, "protein_name": "FAST kinase domain-containing protein 4", "gene_name": "Tbrg4", "organism": "Mouse", "refseq_name": "FAST kinase domain-containing protein 4 isoform 1", "refseq_ac": "NP_001123929", "gene_names_uniprotkb": "Tbrg4; Kiaa0948", "gene_names_refseq": "2310042P22Rik; Cpr2; Tb-12; Tbrg4", "protein_names_uniprotkb": "FAST kinase domain-containing protein 4; Protein TBRG4; Transforming growth factor beta regulator 4", "protein_names_refseq": "FAST kinase domain-containing protein 4 isoform 1; FAST kinase domain-containing protein 4; cell cycle progression 2 protein; protein TBRG4; transforming growth factor beta regulator 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:21379)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18255060;20173027;20869947;21750661;34428180;37507081;9798653", "class_list": "", "function": "Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression., [UniProtKB, UniProtKB]; Tight regulation of WAP gene expression parallels variations in the chromatin structure and DNA methylation profile throughout the Ramp3-WAP-Tbrg4 locus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O89082;Q3TKZ4;Q6ZQ19;Q8C6D1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0000963 mitochondrial RNA processing;GO:0044528 regulation of mitochondrial mRNA stability;GO:0090615 mitochondrial mRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91YM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51865-1", "uniprot_id": "TDGF1_MOUSE", "mass": 18655.0, "length": 171, "protein_name": "Teratocarcinoma-derived growth factor", "gene_name": "Cripto", "organism": "Mouse", "refseq_name": "teratocarcinoma-derived growth factor precursor", "refseq_ac": "NP_035692", "gene_names_uniprotkb": "Cripto; Tdgf1", "gene_names_refseq": "CR1; Cripto; Tdgf1", "protein_names_uniprotkb": "Teratocarcinoma-derived growth factor; Cripto growth factor; Epidermal growth factor-like Cripto protein", "protein_names_refseq": "TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR); cripto growth factor; epidermal growth factor-like Cripto protein; teratocarcinoma-derived growth factor 1; teratocarcinoma-derived growth factor precursor", "tax_id": 10090, "disease": "neural tube defect (Disease Ontology:DOID:0080074); congenital heart disease (Disease Ontology:DOID:1682); colon cancer (Disease Ontology:DOID:219)", "pathway": " (mmu:21667)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10640699;17125258;21750661;37569627;38056454;7916676;8661720", "class_list": "", "function": "CRIPTO-based micro-heterogeneity of mouse muscle satellite cells enables adaptive response to regenerative microenvironment., [RefSeq, PubMed]; Cripto Is Targeted by miR-1a-3p in a Mouse Model of Heart Development. Publication Status: Online-Only, [RefSeq, PubMed]; GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by Tmem8a modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQ06", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:0017147 Wnt-protein binding;GO:0008083 growth factor activity;GO:0038100 nodal binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P51865-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P9Y7-1", "uniprot_id": "ZFP82_MOUSE", "mass": 62122.0, "length": 530, "protein_name": "Zinc finger protein 82", "gene_name": "Zfp82", "organism": "Mouse", "refseq_name": "zinc finger protein 82 isoform 2", "refseq_ac": "NP_001239448", "gene_names_uniprotkb": "Zfp82; Kiaa1948; Znf545", "gene_names_refseq": "A030010D05; Krab16; Mszf3; Zfp-82; Zfp82", "protein_names_uniprotkb": "Zinc finger protein 82; Zfp-82; Zinc finger protein 545", "protein_names_refseq": "zinc finger protein 545; zinc finger protein 82 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:330502)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34615997", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]; ZNF545 loss promotes ribosome biogenesis and protein translation to initiate colorectal tumorigenesis in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPG0;Q8BIP1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P9Y7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R4H9-1", "uniprot_id": "ZNT5_MOUSE", "mass": 83773.0, "length": 761, "protein_name": "Proton-coupled zinc antiporter SLC30A5", "gene_name": "Slc30a5", "organism": "Mouse", "refseq_name": "proton-coupled zinc antiporter SLC30A5", "refseq_ac": "NP_075023", "gene_names_uniprotkb": "Slc30a5; Znt5", "gene_names_refseq": "1810010K08Rik; Slc30a5; ZNT5; ZTL1; ZnT-5; Zntl1", "protein_names_uniprotkb": "Proton-coupled zinc antiporter SLC30A5; Solute carrier family 30 member 5; Zinc transporter 5; ZnT-5", "protein_names_refseq": "proton-coupled zinc antiporter SLC30A5; solute carrier family 30 member 5; zinc transporter 5; zinc transporter like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69048); (R-MMU-264876); (R-MMU-435368)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11904301;11937503;12095919;17101726;19451265;21750661;25428506;31219806;34428180", "class_list": "", "function": "Data suggest that Znt5 is selectively required for the mast cell-mediated delayed-type allergic response, and it is a novel player in mast cell activation., [RefSeq, PubMed]; Functions as a zinc transporter., [UniProtKB, UniProtKB]; Results indicate that Znt5 protein plays an important role in maturation of osteoblasts and in maintenance of the cells involved in the cardiac conduction system, partly owing to dysregulated expression of IEGs and HSPs, [RefSeq, PubMed]; Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis. Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQA0;Q8K315", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046872 metal ion binding;GO:0022883 zinc efflux transmembrane transporter activity;GO:0140826 zinc:proton antiporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006829 zinc ion transport;GO:0010043 response to zinc ion;GO:0006882 intracellular zinc ion homeostasis;GO:0071578 zinc ion import across plasma membrane;GO:0030070 insulin processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R4H9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62384-1", "uniprot_id": "ZPR1_MOUSE", "mass": 50715.0, "length": 459, "protein_name": "Zinc finger protein ZPR1", "gene_name": "Zpr1", "organism": "Mouse", "refseq_name": "zinc finger protein ZPR1", "refseq_ac": "NP_035882", "gene_names_uniprotkb": "Zpr1; Zfp259; Znf259", "gene_names_refseq": "Zfp259; Znf259; Zpr1", "protein_names_uniprotkb": "Zinc finger protein ZPR1; Zinc finger protein 259", "protein_names_refseq": "zinc finger protein 259; zinc finger protein ZPR1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22687)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "15767679;16465397;16648254;17704259;19966453;21750661;22422766;28811488;30084848;31828288;34428180;8650580;9763455;9852145", "class_list": "", "function": "Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. It is involved in the positive regulation of cell cycle progression (By similarity). Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; These findings provide insight into the molecular basis of respiratory failure associated with SMA pathogenesis and identify ZPR1 and HoxA5 as potential targets that lay a foundation for developing therapeutic strategies to treat respiratory distress in SMA. Publication Status: Online-Only, [RefSeq, PubMed]; ZPR1 contributes to the regulation of survival motor neurons complexes and that it is essential for cell survival, [RefSeq, PubMed]; ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy. Erratum:[Brain. 2020 Mar 1;143(3):e24. doi: 10.1093/brain/awaa007. PMID: 32333675], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030971 receptor tyrosine kinase binding;GO:0044183 protein folding chaperone;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0033120 positive regulation of RNA splicing;GO:0006397 mRNA processing;GO:0010628 positive regulation of gene expression;GO:0021510 spinal cord development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q62384-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z109-1", "uniprot_id": "VSIG2_MOUSE", "mass": 34514.0, "length": 328, "protein_name": "V-set and immunoglobulin domain-containing protein 2", "gene_name": "Vsig2", "organism": "Mouse", "refseq_name": "V-set and immunoglobulin domain-containing protein 2 precursor", "refseq_ac": "NP_065264", "gene_names_uniprotkb": "Vsig2; Ctm; Ctxl", "gene_names_refseq": "1190004B15Rik; 2210413P10Rik; CTX; Ctm; Vsig2", "protein_names_uniprotkb": "V-set and immunoglobulin domain-containing protein 2; CT-like protein; Cortical thymocyte-like protein", "protein_names_refseq": "CT-like protein; CTM; V-set and immunoglobulin domain-containing protein 2 precursor; V-set and immunoglobulin domain-containing protein 2; cortical thymocyte receptor (X. laevis CTX) like; cortical thymocyte-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:57276)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;9862345", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9CVA4;Q9D0T4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z109-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5NBU8-1", "uniprot_id": "XAF1_MOUSE", "mass": 31117.0, "length": 273, "protein_name": "XIAP-associated factor 1", "gene_name": "Xaf1", "organism": "Mouse", "refseq_name": "XIAP-associated factor 1 isoform 1", "refseq_ac": "NP_001032802", "gene_names_uniprotkb": "Xaf1; Birc4bp; Xiapaf1", "gene_names_refseq": "Fbox39; Xaf1", "protein_names_uniprotkb": "XIAP-associated factor 1; BIRC4-binding protein", "protein_names_refseq": "BIRC4-binding protein; F-box protein 39; XIAP-associated factor 1 isoform 1; novel TRAF-type zinc finger protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:327959)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18192275;18544999;21750661;27097110;35972291;36394357;37384528;37595039", "class_list": "", "function": "Identification of XAF1 as an endogenous AKT inhibitor., [RefSeq, PubMed]; Interferon gamma induces XAF1 and Noxa expression and potentiates apoptosis by STAT3 activation, [RefSeq, PubMed]; Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity)., [UniProtKB]; XAF1 Protects Host against Emerging RNA Viruses by Stabilizing IRF1-Dependent Antiviral Immunity., [RefSeq, PubMed]; XAF1 may be a candidate tumor suppressor in neuroblastoma, [RefSeq, PubMed]; XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1, Ang-1, Ang-2 and c-Myc may be mechanistically responsible for the observed antiangiogenesis effect., [RefSeq, PubMed]; XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7., [RefSeq, PubMed]; XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZD14;Q3USK3;Q5NBU6;Q5NBU7;Q5NBU9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006915 apoptotic process;GO:0031333 negative regulation of protein-containing complex assembly;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0032481 positive regulation of type I interferon production;GO:0035456 response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5NBU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZW4-1", "uniprot_id": "ZN120_MOUSE", "mass": 51252.0, "length": 436, "protein_name": "Zinc finger protein 120", "gene_name": "Zfp120", "organism": "Mouse", "refseq_name": "zinc finger protein 120 isoform 2 precursor", "refseq_ac": "NP_075755", "gene_names_uniprotkb": "Zfp120", "gene_names_refseq": "E030042N05Rik; F80; MZF31; Zfp120; Zfp844", "protein_names_uniprotkb": "Zinc finger protein 120; Zinc finger protein 31; mZF31", "protein_names_refseq": "zinc finger protein 120 isoform 2 precursor; zinc finger protein 31; zinc finger protein 844", "tax_id": 10090, "disease": "", "pathway": " (mmu:104348); (R-MMU-212436); (R-MMU-9843940)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10360839;21750661;25605945", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78JR8;Q9EQK4;Q9JIB8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BZW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5GH66-1", "uniprot_id": "XKR5_MOUSE", "mass": 74634.0, "length": 676, "protein_name": "XK-related protein 5", "gene_name": "Xkr5", "organism": "Mouse", "refseq_name": "XK-related protein 5 isoform a", "refseq_ac": "NP_001106821", "gene_names_uniprotkb": "Xkr5; Xrg5", "gene_names_refseq": "5430438H03Rik; XRG5; Xkr5", "protein_names_uniprotkb": "XK-related protein 5", "protein_names_refseq": "X Kell blood group precursor-related family, member 5; XK-related protein 5 isoform a; XK-related protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:319581)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25231987;30084848;34203471", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5GH66-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BFR6-1", "uniprot_id": "ZFAN1_MOUSE", "mass": 30203.0, "length": 268, "protein_name": "AN1-type zinc finger protein 1", "gene_name": "Zfand1", "organism": "Mouse", "refseq_name": "AN1-type zinc finger protein 1 isoform 2", "refseq_ac": "NP_001317942", "gene_names_uniprotkb": "Zfand1", "gene_names_refseq": "2310008M20Rik; Zfand1", "protein_names_uniprotkb": "AN1-type zinc finger protein 1; Zinc finger AN1-type-containing protein 1", "protein_names_refseq": "AN1-type zinc finger protein 1 isoform 2; AN1-type zinc finger protein 1; zinc finger AN1-type-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66361)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress. Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome. This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3Y6;Q9D7H5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0090316 positive regulation of intracellular protein transport;GO:0035617 stress granule disassembly;GO:1903843 cellular response to arsenite ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BFR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8K402-1", "uniprot_id": "TBX22_MOUSE", "mass": 58498.0, "length": 517, "protein_name": "T-box transcription factor TBX22", "gene_name": "Tbx22", "organism": "Mouse", "refseq_name": "T-box transcription factor TBX22 isoform 3", "refseq_ac": "NP_001277676", "gene_names_uniprotkb": "Tbx22", "gene_names_refseq": "D230020M15Rik; Tbx22", "protein_names_uniprotkb": "T-box transcription factor TBX22; T-box protein 22", "protein_names_refseq": "T-box protein 22; T-box transcription factor TBX22 isoform 3; T-box transcription factor TBX22", "tax_id": 10090, "disease": "X-linked cleft palate with or without ankyloglossia (Disease Ontology:DOID:0060613); Abruzzo-Erickson syndrome (Disease Ontology:DOID:0111826); cleft palate (Disease Ontology:DOID:674)", "pathway": " (mmu:245572)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12374769;12412015;12666195;18948418;21750661", "class_list": "", "function": "Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia (CPX) phenotype observed in CPX patients., [RefSeq, PubMed]; In mouse embryos, it is expressed in distinct areas of the head, namely the mesenchyme of the inferior nasal septum, the posterior palatal shelf before fusion, the attachment of the tongue, and mesenchymal cells surrounding the eye anlage., [RefSeq, PubMed]; Mn1 and Tbx22 function in a novel molecular pathway regulating mammalian palate development., [RefSeq, PubMed]; Primary role for Tbx22 in both palate and tongue development, [RefSeq, PubMed]; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0090571 RNA polymerase II transcription repressor complex", "go_biological_process": "GO:0001708 cell fate specification;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K402-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9QAN8-1", "uniprot_id": "E9QAN8_MOUSE", "mass": 184178.0, "length": 1632, "protein_name": "Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta", "gene_name": "Pik3c2b", "organism": "Mouse", "refseq_name": "phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta", "refseq_ac": "NP_001092746", "gene_names_uniprotkb": "Pik3c2b", "gene_names_refseq": "C330011J12Rik; Gm199; PI3K-C2beta; PI3KC2beta; Pik3c2b", "protein_names_uniprotkb": "Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta", "protein_names_refseq": "phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; phosphoinositide-3-kinase, class 2, beta polypeptide", "tax_id": 10090, "disease": "", "pathway": " (mmu:240752); (R-MMU-1660499)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16222711;21750661;33370494;36943412;37975768;38015911", "class_list": "", "function": "Inactivating the lipid kinase activity of PI3KC2beta is sufficient to rescue myotubular myopathy in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Our findings demonstrate for the first time that the PI3K-C2beta isoform associates with clathrin and thus provides a link between receptor mediated intracellular signalling and clathrin coated vesicle transport., [RefSeq, PubMed]; PI3K-C2beta limits mTORC1 signaling and angiogenic growth., [RefSeq, PubMed]; Uninephrectomy and class II PI3K-C2beta inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice., [RefSeq, PubMed]; [PI3KC2beta: A promising therapeutic target in myotubular myopathy]., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.1", "go_molecular_function": "GO:0001727 lipid kinase activity;GO:0005524 ATP binding;GO:0035091 phosphatidylinositol binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0016477 cell migration;GO:0016236 macroautophagy;GO:0048015 phosphatidylinositol-mediated signaling;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "E9QAN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UDP0-1", "uniprot_id": "WDR41_MOUSE", "mass": 51511.0, "length": 460, "protein_name": "WD repeat-containing protein 41", "gene_name": "Wdr41", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 41", "refseq_ac": "NP_766178", "gene_names_uniprotkb": "Wdr41", "gene_names_refseq": "B830029I03Rik; MSTP048; Wdr41", "protein_names_uniprotkb": "WD repeat-containing protein 41", "protein_names_refseq": "WD repeat-containing protein 41", "tax_id": 10090, "disease": "", "pathway": " (mmu:218460)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;27617292", "class_list": "", "function": "Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function (By similarity). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity., [UniProtKB, UniProtKB]; This gene encodes a protein of unknown function, but which contains a WD40 domain consisting of six WD40 repeats. The WD40 domain is one of the most abundant protein domains in eukaryotes, and is found in proteins with widely varying cellular functions. However, proteins with this domain often provide a rigid scaffold for protein-protein interactions. [provided by RefSeq, Aug 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4F1;Q8C8K5", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032045 guanyl-nucleotide exchange factor complex", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0006914 autophagy;GO:0050777 negative regulation of immune response;GO:0045920 negative regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UDP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D5R2-1", "uniprot_id": "WDR20_MOUSE", "mass": 62782.0, "length": 567, "protein_name": "WD repeat-containing protein 20", "gene_name": "Wdr20rt; Wdr20", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 20", "refseq_ac": "NP_081890", "gene_names_uniprotkb": "Wdr20rt; Wdr20; Wdr20b; Wdr20rt", "gene_names_refseq": "4921538B03Rik; 4930427E19Rik; Wdr20b; Wdr20rt; Wdr20", "protein_names_uniprotkb": "WD repeat-containing protein 20", "protein_names_refseq": "WD repeat domain 20b; WD repeat-containing protein 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:70948)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31599954;34428180", "class_list": "", "function": "Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme. Regulates shuttling of complexes containing USP12 between the plasma membrane, cytoplasm and nucleus., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80X67;Q9D5L0", "ec_number_list": "", "go_molecular_function": "GO:0035800 deubiquitinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1905368 peptidase complex", "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D5R2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35188-1", "uniprot_id": "X3CL1_MOUSE", "mass": 42099.0, "length": 395, "protein_name": "Fractalkine", "gene_name": "Cx3cl1", "organism": "Mouse", "refseq_name": "fractalkine precursor", "refseq_ac": "NP_033168", "gene_names_uniprotkb": "Cx3cl1; Cx3c; Fkn; Scyd1", "gene_names_refseq": "ABCD-3; CX3C; Cx3cl1; Cxc3; D8Bwg0439e; FK; Scyd1", "protein_names_uniprotkb": "Fractalkine; ABCD-3; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; FK; Neurotactin; Small-inducible cytokine D1", "protein_names_refseq": "C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; chemokine (C-X3-C motif) ligand 1; fractalkine precursor; fractalkine; neurotactin; small inducible cytokine subfamily D, 1; small-inducible cytokine D1", "tax_id": 10090, "disease": "polymyositis (Disease Ontology:DOID:0080745); Parkinsonism (Disease Ontology:DOID:0080855); dermatomyositis (Disease Ontology:DOID:10223); common cold (Disease Ontology:DOID:10459); portal hypertension (Disease Ontology:DOID:10762); uveitis (Disease Ontology:DOID:13141); cystitis (Disease Ontology:DOID:1679); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); glomerulonephritis (Disease Ontology:DOID:2921); ischemia (Disease Ontology:DOID:326); atopic dermatitis (Disease Ontology:DOID:3310); systemic scleroderma (Disease Ontology:DOID:418); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); borna disease (Disease Ontology:DOID:5154); pulmonary hypertension (Disease Ontology:DOID:6432); prion disease (Disease Ontology:DOID:649); rheumatoid arthritis (Disease Ontology:DOID:7148); myocarditis (Disease Ontology:DOID:820); lung disease (Disease Ontology:DOID:850); Cor pulmonale (Disease Ontology:DOID:8515); chronic fatigue syndrome (Disease Ontology:DOID:8544); hepatopulmonary syndrome (Disease Ontology:DOID:900); pulmonary embolism (Disease Ontology:DOID:9477); polyarteritis nodosa (Disease Ontology:DOID:9810)", "pathway": " (mmu:20312); (R-MMU-380108); (R-MMU-418594)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10187784;10382755;10508268;11287620;12569158;18971423;21750661;24788674;9177350;9479488;9845323", "class_list": "", "function": "Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1 (PubMed:10187784, PubMed:18971423). The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:10187784, PubMed:10382755, PubMed:18971423, PubMed:9177350). Regulates leukocyte adhesion and migration processes at the endothelium (PubMed:10382755, PubMed:9177350). Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner (By similarity). In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins (By similarity). In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The membrane-bound form promotes adhesion of those leukocytes to endothelial cells., [UniProtKB, UniProtKB]; The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 29, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35933;Q91V44", "ec_number_list": "", "go_molecular_function": "GO:0031737 CX3C chemokine receptor binding;GO:0005178 integrin binding;GO:0042056 chemoattractant activity;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:1904141 positive regulation of microglial cell migration;GO:1903979 negative regulation of microglial cell activation;GO:0032233 positive regulation of actin filament bundle assembly;GO:0032914 positive regulation of transforming growth factor beta1 production;GO:0051041 positive regulation of calcium-independent cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O35188-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CZY2-1", "uniprot_id": "TCAL8_MOUSE", "mass": 13472.0, "length": 117, "protein_name": "Transcription elongation factor A protein-like 8", "gene_name": "Tceal8", "organism": "Mouse", "refseq_name": "transcription elongation factor A protein-like 8", "refseq_ac": "NP_001162050", "gene_names_uniprotkb": "Tceal8", "gene_names_refseq": "3930402F23Rik; Tceal8", "protein_names_uniprotkb": "Transcription elongation factor A protein-like 8; TCEA-like protein 8; Transcription elongation factor S-II protein-like 8", "protein_names_refseq": "TCEA-like protein 8; transcription elongation factor A protein-like 8; transcription elongation factor S-II protein-like 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:66684)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31827131", "class_list": "", "function": "Defined factors to reactivate cell cycle activity in adult mouse cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJR7;Q9CYP9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CZY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16372-1", "uniprot_id": "ZFP58_MOUSE", "mass": 57232.0, "length": 489, "protein_name": "Zinc finger protein 58", "gene_name": "Zfp58", "organism": "Mouse", "refseq_name": "zinc finger protein 58", "refseq_ac": "NP_001007576", "gene_names_uniprotkb": "Zfp58; Mfg-1; Rslcan5; Zfp817", "gene_names_refseq": "A530094I17Rik; Mfg-1; Mfg1; Rslcan5; Zfp58; Zfp817", "protein_names_uniprotkb": "Zinc finger protein 58; Regulator of sex-limitation candidate 5; Zfp-58; Zinc finger protein Mfg-1", "protein_names_refseq": "KRAB zinc finger protein; regulator of sex-limitation candidate 5; zfp-58; zinc finger protein 58; zinc finger protein 817; zinc finger protein Mfg-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:238693); (R-MMU-212436)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "14563677;21750661;2512579", "class_list": "", "function": "May have a role during differentiation processes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS54;Q6P8L3;Q7M6X1;Q8BRV1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P16372-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0U1RPR8-1", "uniprot_id": "GUC2D_MOUSE", "mass": 122528.0, "length": 1117, "protein_name": "Guanylate cyclase D", "gene_name": "Gucy2d", "organism": "Mouse", "refseq_name": "guanylate cyclase D precursor", "refseq_ac": "NP_001124165", "gene_names_uniprotkb": "Gucy2d", "gene_names_refseq": "Gucy2d", "protein_names_uniprotkb": "Guanylate cyclase D; 4.6.1.2", "protein_names_refseq": "guanylate cyclase D precursor; guanylate cyclase D; guanylyl cyclase 2d; guanylyl cyclase D; olfactory guanylyl cyclase GC-D", "tax_id": 10090, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (mmu:14918)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14993224;17702944;17724338;20637621;21750661;25428506;27881908;32841674;35820727;9096404", "class_list": "", "function": "Functions as an olfactory receptor activated by urine odorants, uroguanylin and guanylin and as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2) (PubMed:17702944, PubMed:17724338, PubMed:20637621). Has guanylate cyclase activity upon binding of the ligand (By similarity). Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency (PubMed:17724338, PubMed:20637621). Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference (PubMed:20637621)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Mg(2+) binding to GCAPs is critical for setting the actual dynamic range of RetGC regulation by GCAPs at physiological levels of free Ca(2+), [RefSeq, PubMed]; Sensory neurons expressing the atypical olfactory receptor guanylyl cyclase D are required for the acquisition of odor preferences by mice in diverse social contexts., [RefSeq, PubMed]; The S248W mutation contributes to Leber congenital amaurosis 1 by hampering the expression, processing, and/or cellular transport of GUCY2D, rather than its enzymatic properties. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.6.1.2", "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0016941 natriuretic peptide receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0097730 non-motile cilium;GO:0060170 ciliary membrane;GO:0016020 membrane", "go_biological_process": "GO:0042048 olfactory behavior;GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0U1RPR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A958-1", "uniprot_id": "A2A958_MOUSE", "mass": 56719.0, "length": 498, "protein_name": "PRAME like 29", "gene_name": "Pramel29", "organism": "Mouse", "refseq_name": "novel oogenesin protein", "refseq_ac": "NP_001171013", "gene_names_uniprotkb": "Pramel29", "gene_names_refseq": "Pramel29", "protein_names_uniprotkb": "PRAME like 29", "protein_names_refseq": "novel oogenesin (Oog) protein; novel oogenesin protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:97187)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2A958-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCN9-1", "uniprot_id": "TBCC_MOUSE", "mass": 38125.0, "length": 341, "protein_name": "Tubulin-specific chaperone C", "gene_name": "Tbcc", "organism": "Mouse", "refseq_name": "tubulin-specific chaperone C", "refseq_ac": "NP_848472", "gene_names_uniprotkb": "Tbcc", "gene_names_refseq": "2810055C19Rik; Tbcc", "protein_names_uniprotkb": "Tubulin-specific chaperone C; CFC; Tubulin-folding cofactor C", "protein_names_refseq": "CFC; tubulin-folding cofactor C; tubulin-specific chaperone C", "tax_id": 10090, "disease": "", "pathway": " (mmu:72726)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Tubulin-folding protein; involved in the final step of the tubulin folding pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V242", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0015631 tubulin binding;GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:0006457 protein folding;GO:0007021 tubulin complex assembly;GO:0007023 post-chaperonin tubulin folding pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VCN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D6T1-1", "uniprot_id": "TBE_MOUSE", "mass": 52652.0, "length": 475, "protein_name": "Tubulin epsilon chain", "gene_name": "Tube1", "organism": "Mouse", "refseq_name": "tubulin epsilon chain", "refseq_ac": "NP_082282", "gene_names_uniprotkb": "Tube1", "gene_names_refseq": "2310061K05Rik; Tube1; Tube", "protein_names_uniprotkb": "Tubulin epsilon chain; Epsilon-tubulin", "protein_names_refseq": "epsilon-tubulin 1; tubulin epsilon chain", "tax_id": 10090, "disease": "", "pathway": " (mmu:71924)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;29459677", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007010 cytoskeleton organization;GO:0000226 microtubule cytoskeleton organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D6T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35437-1", "uniprot_id": "TCF21_MOUSE", "mass": 19681.0, "length": 179, "protein_name": "Transcription factor 21", "gene_name": "Tcf21", "organism": "Mouse", "refseq_name": "transcription factor 21", "refseq_ac": "NP_035675", "gene_names_uniprotkb": "Tcf21; Pod1", "gene_names_refseq": "Pod-1; Pod1; Tcf21; bHLHa23; capsulin; epc; epicardin", "protein_names_uniprotkb": "Transcription factor 21; Capsulin; Epicardin; Pod-1; Podocyte-expressed 1; TCF-21", "protein_names_refseq": "podocyte-expressed 1; transcription factor 21", "tax_id": 10090, "disease": "ventricular septal defect (Disease Ontology:DOID:1657); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (mmu:21412)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10572052;10944221;11287187;21750661;34428180;9545521;9545526;9733105", "class_list": "", "function": "Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May be involved in the organogenesis of the spleen and heart and in cardiac and coronary artery development. May function in the development and sex differentiation of gonad via transcriptional regulation of AD4BP/SF-1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U023", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0042826 histone deacetylase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0007530 sex determination;GO:0060435 bronchiole development;GO:0072162 metanephric mesenchymal cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35437-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56840-1", "uniprot_id": "TCLB1_MOUSE", "mass": 13432.0, "length": 116, "protein_name": "Protein TCL1B1", "gene_name": "Tcl1b1", "organism": "Mouse", "refseq_name": "protein TCL1B1 isoform 1", "refseq_ac": "NP_038801", "gene_names_uniprotkb": "Tcl1b1", "gene_names_refseq": "Tcl1b1", "protein_names_uniprotkb": "Protein TCL1B1", "protein_names_refseq": "protein TCL1B1 isoform 1; protein TCL1B1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27379)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10588720;21750661;31599954", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56840-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3KGA4-1", "uniprot_id": "TCAL7_MOUSE", "mass": 11697.0, "length": 98, "protein_name": "Transcription elongation factor A protein-like 7", "gene_name": "Tceal7", "organism": "Mouse", "refseq_name": "transcription elongation factor A protein-like 7", "refseq_ac": "NP_001120641", "gene_names_uniprotkb": "Tceal7", "gene_names_refseq": "1110018P05Rik; Tceal7", "protein_names_uniprotkb": "Transcription elongation factor A protein-like 7; TCEA-like protein 7; Transcription elongation factor S-II protein-like 7", "protein_names_refseq": "TCEA-like protein 7; transcription elongation factor A protein-like 7; transcription elongation factor S-II protein-like 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:100040972)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15870691;20307260;21750661;35216152;37047236", "class_list": "", "function": "Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines (By similarity)., [UniProtKB]; Tceal5 and Tceal7 Function in C2C12 Myogenic Differentiation via Exosomes in Fetal Bovine Serum. Publication Status: Online-Only, [RefSeq, PubMed]; Tceal7 Regulates Skeletal Muscle Development through Its Interaction with Cdk1. Publication Status: Online-Only, [RefSeq, PubMed]; The studies support the hypothesis that MRFs transactivate Tceal7 gene expression and promote muscle differentiation during muscle development and regeneration. Publication Status: Online-Only, [RefSeq, PubMed]; These data implicate human TCEAL7 as a cell death regulatory protein that is frequently inactivated in ovarian cancers, and suggest that it may function as a tumor suppressor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A3KGA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61390-1", "uniprot_id": "TCPW_MOUSE", "mass": 58185.0, "length": 531, "protein_name": "Probable T-complex protein 1 subunit zeta-2", "gene_name": "Cct6b", "organism": "Mouse", "refseq_name": "probable T-complex protein 1 subunit zeta-2 isoform 1", "refseq_ac": "NP_033969", "gene_names_uniprotkb": "Cct6b", "gene_names_refseq": "CCT-zeta-2; CCTzeta-2; Cct6b; Cctz-2; TCP-1-zeta-2", "protein_names_uniprotkb": "Probable T-complex protein 1 subunit zeta-2; 3.6.1.-; CCT-zeta-2; Cctz-2", "protein_names_refseq": "T-complex protein 1 subunit zeta-2; chaperonin containing Tcp1, subunit 6b (zeta); chaperonin subunit 6b (zeta); probable T-complex protein 1 subunit zeta-2 isoform 1; probable T-complex protein 1 subunit zeta-2", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (mmu:12467); (R-MMU-390471); (R-MMU-6814122)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10336634;21750661;31219806;34141486;40684658;9013858", "class_list": "", "function": "Could function as a component of a tissue-specific chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1U2", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.1.91;2.3.1.-;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005829 cytosol;GO:0005832 chaperonin-containing T-complex", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q61390-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P80316-1", "uniprot_id": "TCPE_MOUSE", "mass": 59624.0, "length": 541, "protein_name": "T-complex protein 1 subunit epsilon", "gene_name": "Cct5", "organism": "Mouse", "refseq_name": "T-complex protein 1 subunit epsilon isoform 2", "refseq_ac": "NP_001334964", "gene_names_uniprotkb": "Cct5; Ccte; Kiaa0098", "gene_names_refseq": "CCT-epsilon; Cct5; Ccte; TCP-1-epsilon; TCPE; mKIAA0098", "protein_names_uniprotkb": "T-complex protein 1 subunit epsilon; 3.6.1.-; CCT-epsilon; TCP-1-epsilon", "protein_names_refseq": "T-complex protein 1 subunit epsilon isoform 2; T-complex protein 1 subunit epsilon; chaperonin containing Tcp1, subunit 5 (epsilon)", "tax_id": 10090, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); autosomal recessive sensory neuropathy with spastic paraplegia (Disease Ontology:DOID:0061188); Bardet-Biedl syndrome 10 (Disease Ontology:DOID:0110132); sensory peripheral neuropathy (Disease Ontology:DOID:2491)", "pathway": " (mmu:12465); (R-MMU-390471); (R-MMU-5620922); (R-MMU-6814122)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "10336634;10747865;18299400;20484733;20485683;21750661;21880732;21952136;22645316;23872636;25428506;30084848;30779550;33300544;34260942;34428180;34887587;35820727;37453647;37507081;38153635;39627609;39927985;7953530", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia., [UniProtKB, UniProtKB]; The Chaperone Protein Cct5 is Essential for Hematopoietic Stem Cell Maintenance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TIE0;Q3U530;Q3UCU4;Q3UJK9;Q3UWA9;Q542K3;Q6ZQJ1", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.1.91;2.3.1.-;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule;GO:0043209 myelin sheath;GO:0044297 cell body;GO:0005832 chaperonin-containing T-complex", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0009615 response to virus;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P80316-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R1K7-1", "uniprot_id": "TBD_MOUSE", "mass": 51023.0, "length": 455, "protein_name": "Tubulin delta chain", "gene_name": "Tubd1", "organism": "Mouse", "refseq_name": "tubulin delta chain isoform 2", "refseq_ac": "NP_001185976", "gene_names_uniprotkb": "Tubd1", "gene_names_refseq": "4930550G19Rik; Tubd1; Tubd", "protein_names_uniprotkb": "Tubulin delta chain; Delta-tubulin", "protein_names_refseq": "delta-tubulin; tubulin delta chain isoform 2; tubulin delta chain", "tax_id": 10090, "disease": "", "pathway": " (mmu:56427)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10753753;21750661;29290584;29459677;30084848;31219806;34428180", "class_list": "", "function": "Acts as a positive regulator of hedgehog signaling and regulates ciliary function (PubMed:29290584)., [UniProtKB, PubMed]; Loss-of-function mutations in Tubd1 prevent cells from assembling primary cilia and consequently lead to the failure to respond to Hedgehog ligands. Erratum:[Dev Cell. 2018 Jan 22;44(2):271. doi: 10.1016/j.devcel.2018.01.002. PMID: 29401421], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0000278 mitotic cell cycle;GO:0007010 cytoskeleton organization;GO:0000226 microtubule cytoskeleton organization;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9R1K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CAY6-1", "uniprot_id": "THIC_MOUSE", "mass": 41298.0, "length": 397, "protein_name": "Acetyl-CoA acetyltransferase, cytosolic", "gene_name": "Acat2", "organism": "Mouse", "refseq_name": "acetyl-CoA acetyltransferase, cytosolic", "refseq_ac": "NP_033364", "gene_names_uniprotkb": "Acat2", "gene_names_refseq": "Acat2; Tcp-1x; Tcp1-rs1", "protein_names_uniprotkb": "Acetyl-CoA acetyltransferase, cytosolic; 2.3.1.9; Cytosolic acetoacetyl-CoA thiolase", "protein_names_refseq": "acetyl-CoA acetyltransferase, cytosolic; cytosolic acetoacetyl-CoA thiolase; t-complex protein 1, related sequence 1", "tax_id": 10090, "disease": "coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (mmu:110460); (R-MMU-9969896)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "2055458;21750661;30084848;31219806;34428180;36378328;37453647;37828378", "class_list": "", "function": "Hepatic Acat2 overexpression promotes systemic cholesterol metabolism and adipose lipid metabolism in mice., [RefSeq, PubMed]; Involved in the biosynthetic pathway of cholesterol., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TJY7;Q62292;Q96EB7;Q99K88;Q9CYV2", "ec_number_list": "3.1.2.2;3.1.2.-;3.1.2.22;2.3.1.176;2.3.1.16;2.3.1.155;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;3.1.1.4;3.1.1.5;3.5.2.6;2.3.1.9;3.1.2.14;2.3.1.65", "go_molecular_function": "GO:0003985 acetyl-CoA C-acetyltransferase activity;GO:0003986 acetyl-CoA hydrolase activity;GO:0003988 acetyl-CoA C-acyltransferase activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol;GO:0033490 cholesterol biosynthetic process via lathosterol", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CAY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01849-1", "uniprot_id": "TRAC_MOUSE", "mass": 15234.0, "length": 136, "protein_name": "T-cell receptor alpha chain constant", "gene_name": "Trac", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Trac", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell receptor alpha chain constant", "protein_names_refseq": "", "tax_id": 10090, "disease": "immunodeficiency 7 (Disease Ontology:DOID:0111977)", "pathway": " (R-MMU-198933); (R-MMU-202424); (R-MMU-202427); (R-MMU-202430); (R-MMU-202433); (R-MMU-389948)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "21750661;2946043;6208487;6548551;8163944", "class_list": "", "function": "Constant region of T cell receptor (TR) alpha chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A075B662", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042105 alpha-beta T cell receptor complex", "go_biological_process": "GO:0009617 response to bacterium;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P01849-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P03985-1", "uniprot_id": "TCC2_MOUSE", "mass": 19797.0, "length": 172, "protein_name": "T-cell receptor gamma chain C region C7.5", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell receptor gamma chain C region C7.5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3917858", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P03985-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55099-1", "uniprot_id": "TKNK_MOUSE", "mass": 12737.0, "length": 116, "protein_name": "Tachykinin-3", "gene_name": "Tac3", "organism": "Mouse", "refseq_name": "tachykinin-3 preproprotein", "refseq_ac": "NP_001186900", "gene_names_uniprotkb": "Tac3; Nknb; Tac2", "gene_names_refseq": "PPT-B; Tac2; Tac3", "protein_names_uniprotkb": "Tachykinin-3; Neurokinin B-like protein Zneurok1; Neuromedin-K; PPT-B; Preprotachykinin-B", "protein_names_refseq": "neurokinin 2; neurokinin A; neurokinin B-like protein Zneurok1; neurokinin alpha; neuromedin L; neuropeptide K; preprotachykinin-B; substance K; tachykinin-3 preproprotein; tachykinin-3", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 10 with or without anosmia (Disease Ontology:DOID:0090089); hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:21334); (R-MMU-380095); (R-MMU-416476)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12773411;16160861", "class_list": "", "function": "Incongruent pattern of neurokinin B expression in rat and mouse brains., [RefSeq, PubMed]; Is a ligand for TACR3, and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (By similarity). Binding to TACR3 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity). Is a critical central regulator of gonadal function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Preprotachykinin (PPT)-B genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function., [RefSeq, PubMed]; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles., [UniProtKB]; This gene encodes a member of the tachykinin family of signaling peptides that is widely expressed in the central nervous system and plays a role in diverse processes such as water homeostasis, pulmonary inflammation, cognition, fear memory consolidation and preeclampsia. The encoded protein is enzymatically processed to generate the mature neuropeptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXS9", "ec_number_list": "", "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0045777 positive regulation of blood pressure;GO:0007209 phospholipase C-activating tachykinin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P55099-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56842-1", "uniprot_id": "TCLB3_MOUSE", "mass": 14170.0, "length": 122, "protein_name": "Protein TCL1B3", "gene_name": "Tcl1b3", "organism": "Mouse", "refseq_name": "protein TCL1B3", "refseq_ac": "NP_038800", "gene_names_uniprotkb": "Tcl1b3", "gene_names_refseq": "Tcl1b3", "protein_names_uniprotkb": "Protein TCL1B3", "protein_names_refseq": "protein TCL1B3", "tax_id": 10090, "disease": "", "pathway": " (mmu:27378)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10588720", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P56842-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3B807-1", "uniprot_id": "TCRGL_MOUSE", "mass": 66376.0, "length": 590, "protein_name": "Transcription elongation regulator 1-like protein", "gene_name": "Tcerg1l", "organism": "Mouse", "refseq_name": "transcription elongation regulator 1-like protein", "refseq_ac": "NP_899112", "gene_names_uniprotkb": "Tcerg1l", "gene_names_refseq": "5730476P14Rik; Tcerg1l", "protein_names_uniprotkb": "Transcription elongation regulator 1-like protein", "protein_names_refseq": "transcription elongation regulator 1-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:70571)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31219806;33959758", "class_list": "", "function": "Roles of Stra8 and Tcerg1l in retinoic acid induced spermatogonial differentiation in mousedagger., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZP6;Q8BT57", "ec_number_list": "", "go_molecular_function": "GO:0070063 RNA polymerase binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3B807-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UX10-1", "uniprot_id": "TBAL3_MOUSE", "mass": 49988.0, "length": 446, "protein_name": "Tubulin alpha chain-like 3", "gene_name": "Tubal3", "organism": "Mouse", "refseq_name": "tubulin alpha chain-like 3 isoform 1", "refseq_ac": "NP_001029051", "gene_names_uniprotkb": "Tubal3", "gene_names_refseq": "Tubal3", "protein_names_uniprotkb": "Tubulin alpha chain-like 3; 3.6.5.-", "protein_names_refseq": "tubulin alpha chain-like 3 isoform 1; tubulin alpha chain-like 3", "tax_id": 10090, "disease": "lissencephaly (Disease Ontology:DOID:0050453); polymicrogyria (Disease Ontology:DOID:0080918); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234)", "pathway": " (mmu:238463); (R-MMU-190840); (R-MMU-2132295); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-3371497); (R-MMU-380320); (R-MMU-437239); (R-MMU-5620920); (R-MMU-5626467); (R-MMU-5663220); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811436); (R-MMU-68877); (R-MMU-8852276); (R-MMU-8955332); (R-MMU-9646399); (R-MMU-9648025); (R-MMU-9668328); (R-MMU-983189); (R-MMU-9833482)", "pathway_count": 22, "publication_count": 1, "publication_id_list": "30084848", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJS3", "ec_number_list": "3.6.5.-;6.3.2.-;6.-.-.-;3.6.5.2;3.6.5.3;2.7.11.1;2.4.1.41;3.6.1.5;2.7.11.11;3.6.4.10;2.7.11.22;2.7.11.23;3.6.5.4;5.6.1.6;3.6.4.-;5.2.1.8;5.6.1.3;3.6.5.5;3.4.22.49;3.1.3.16;3.6.1.-;2.7.10.2;2.7.11.21;3.6.1.15;3.4.21.-;3.6.4.12;3.6.-.-;2.3.1.108;3.1.2.-;3.5.1.-;3.5.1.124;2.3.1.-;2.7.11.26;2.3.2.-;3.1.11.-;5.6.1.1;5.3.99.3", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UX10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62381-1", "uniprot_id": "TLL1_MOUSE", "mass": 114533.0, "length": 1013, "protein_name": "Tolloid-like protein 1", "gene_name": "Tll1", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Tll1; Tll", "gene_names_refseq": "", "protein_names_uniprotkb": "Tolloid-like protein 1; 3.4.24.-; mTll", "protein_names_refseq": "", "tax_id": 10090, "disease": "atrial heart septal defect 6 (Disease Ontology:DOID:0110111); congenital heart disease (Disease Ontology:DOID:1682); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (R-MMU-1650814); (R-MMU-2214320); (R-MMU-2243919)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10331975;10479448;10896944;11313359;21750661;30016717;34418053;37828378;8661043", "class_list": "", "function": "Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development, especially heart development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTT9;Q8BNP5", "ec_number_list": "1.4.3.13;3.4.24.19;3.4.24.-;1.4.3.-", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0016485 protein processing;GO:0030154 cell differentiation;GO:0009953 dorsal/ventral pattern formation;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q62381-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q640P7-1", "uniprot_id": "TBCC1_MOUSE", "mass": 62848.0, "length": 552, "protein_name": "TBCC domain-containing protein 1", "gene_name": "Tbccd1", "organism": "Mouse", "refseq_name": "TBCC domain-containing protein 1", "refseq_ac": "NP_001074837", "gene_names_uniprotkb": "Tbccd1", "gene_names_refseq": "5730478M09Rik; Tbccd1", "protein_names_uniprotkb": "TBCC domain-containing protein 1", "protein_names_refseq": "TBCC domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70573)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20168327;21750661;31219806;34428180;36210013", "class_list": "", "function": "Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q68FM1;Q8CA17;Q9CYG4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031616 spindle pole centrosome", "go_biological_process": "GO:0051684 maintenance of Golgi location;GO:0030334 regulation of cell migration;GO:0008360 regulation of cell shape;GO:0051661 maintenance of centrosome location", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q640P7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6QNU9-1", "uniprot_id": "TLR12_MOUSE", "mass": 99945.0, "length": 906, "protein_name": "Toll-like receptor 12", "gene_name": "Tlr12", "organism": "Mouse", "refseq_name": "toll-like receptor 12 precursor", "refseq_ac": "NP_991392", "gene_names_uniprotkb": "Tlr12; Gm1365; Tlr11", "gene_names_refseq": "Gm1365; Tlr11; Tlr12", "protein_names_uniprotkb": "Toll-like receptor 12; Toll-like receptor 11", "protein_names_refseq": "toll-like receptor 11; toll-like receptor 12 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:384059)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;14993594;15001781;19077284;26740625;34428180", "class_list": "", "function": "Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in preventing infection of internal organs of the urogenital system., [UniProtKB, PubMed]; TLRs 11-13 are expressed in normal and parasite infected mouse brains. This suggests a role for them in central nervous system infections. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0002224 toll-like receptor signaling pathway;GO:0042832 defense response to protozoan", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6QNU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6R5N8-1", "uniprot_id": "TLR13_MOUSE", "mass": 114443.0, "length": 991, "protein_name": "Toll-like receptor 13", "gene_name": "Tlr13", "organism": "Mouse", "refseq_name": "toll-like receptor 13 precursor", "refseq_ac": "NP_991389", "gene_names_uniprotkb": "Tlr13", "gene_names_refseq": "Gm713; Tlr13", "protein_names_uniprotkb": "Toll-like receptor 13", "protein_names_refseq": "toll-like receptor 13 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:279572)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;14993594;17452530;19077284;19487701;21131352;22821982;22896636;26740625;30084848;31219806;34428180;35088922", "class_list": "", "function": "Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences., [UniProtKB, PubMed, PubMed, PubMed]; TLR13 contributes to skeletal muscle atrophy by increasing insulin resistance in chronic kidney disease., [RefSeq, PubMed]; TLRs 11-13 are expressed in normal and parasite infected mouse brains. This suggests a role for them in central nervous system infections. Publication Status: Online-Only, [RefSeq, PubMed]; The potential role of the novel Toll-like receptor tlr13 in the recognition of viral infection., [RefSeq, PubMed]; These findings reveal the mechanism of Tlr13 gene regulation, thereby providing insight into the function of Tlr13 in the immune response to pathogen., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 19, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 15, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 19, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 19, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9452, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "Q148Y7;Q3TDS2", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0019843 rRNA binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0009615 response to virus;GO:0002224 toll-like receptor signaling pathway;GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q6R5N8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZW2-1", "uniprot_id": "THEM6_MOUSE", "mass": 23803.0, "length": 207, "protein_name": "Protein THEM6", "gene_name": "Them6", "organism": "Mouse", "refseq_name": "protein THEM6 precursor", "refseq_ac": "NP_941009", "gene_names_uniprotkb": "Them6", "gene_names_refseq": "4930572J05Rik; Them6", "protein_names_uniprotkb": "Protein THEM6", "protein_names_refseq": "UPF0670 protein C8orf55 homolog; UPF0670 protein THEM6 homolog; mesenchymal stem cell protein DSCD75 homolog; protein THEM6 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:223626)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31219806;33300544", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80ZW2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BM85-1", "uniprot_id": "TBCK_MOUSE", "mass": 100640.0, "length": 893, "protein_name": "TBC domain-containing protein kinase-like protein", "gene_name": "Tbck", "organism": "Mouse", "refseq_name": "TBC domain-containing protein kinase-like protein", "refseq_ac": "NP_001156927", "gene_names_uniprotkb": "Tbck", "gene_names_refseq": "1700120J03Rik; 9430001M19; A630047E20Rik; C030007I09Rik; Tbckl; Tbck", "protein_names_uniprotkb": "TBC domain-containing protein kinase-like protein; FERRY endosomal RAB5A effector complex subunit 1", "protein_names_refseq": "FERRY endosomal RAB5A effector complex subunit 1; TBC domain-containing protein kinase-like protein", "tax_id": 10090, "disease": "infantile hypotonia with psychomotor retardation and characteristic facies-3 (Disease Ontology:DOID:0060935)", "pathway": " (mmu:271981)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19372376;37353954", "class_list": "", "function": "Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (By similarity). Also involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the control of actin-cytoskeleton organization (By similarity)., [UniProtKB, UniProtKB]; Heterozygous variants in TBCK cause a mild neurologic syndrome in humans and mice., [RefSeq, PubMed]; Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~49%., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q1W7;Q8BWD3;Q8BY53", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0030496 midbody;GO:0072686 mitotic spindle", "go_biological_process": "GO:0008283 cell population proliferation;GO:0030036 actin cytoskeleton organization;GO:0032006 regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BM85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q921K8-1", "uniprot_id": "TCAF2_MOUSE", "mass": 101598.0, "length": 919, "protein_name": "TRPM8 channel-associated factor 2", "gene_name": "Tcaf2", "organism": "Mouse", "refseq_name": "TRPM8 channel-associated factor 2", "refseq_ac": "NP_666286", "gene_names_uniprotkb": "Tcaf2; Fam115c; Fam139a", "gene_names_refseq": "Fam115c; Tcaf2", "protein_names_uniprotkb": "TRPM8 channel-associated factor 2; TRP channel-associated factor 2", "protein_names_refseq": "TRP channel-associated factor 2; TRPM8 channel-associated factor 2; family with sequence similarity 115, member C; protein FAM115C", "tax_id": 10090, "disease": "", "pathway": " (mmu:232748)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25559186;30084848;34428180", "class_list": "", "function": "Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner., [UniProtKB, UniProtKB]; Report novel TRP channel-associated factors that modulate TRPM8 activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6KAN8;Q922C4", "ec_number_list": "", "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0090314 positive regulation of protein targeting to membrane;GO:0002244 hematopoietic progenitor cell differentiation;GO:0010360 negative regulation of anion channel activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q921K8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99JT6-1", "uniprot_id": "TLCD1_MOUSE", "mass": 28787.0, "length": 247, "protein_name": "TLC domain-containing protein 1", "gene_name": "Tlcd1", "organism": "Mouse", "refseq_name": "TLC domain-containing protein 1 isoform c", "refseq_ac": "NP_001278165", "gene_names_uniprotkb": "Tlcd1", "gene_names_refseq": "Tlcd1", "protein_names_uniprotkb": "TLC domain-containing protein 1; Calfacilitin", "protein_names_refseq": "TLC domain-containing protein 1 isoform c; TLC domain-containing protein 1; calfacilitin", "tax_id": 10090, "disease": "", "pathway": " (mmu:68385)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;30084848", "class_list": "", "function": "Regulates the composition and fluidity of the plasma membrane (By similarity). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (By similarity). Does not appear to have any effect on LCPUFA synthesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V372;Q5SYM9;Q8CHT9;Q9DCK5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0055091 phospholipid homeostasis;GO:0071709 membrane assembly;GO:0097035 regulation of membrane lipid distribution", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99JT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99N14-1", "uniprot_id": "TKN4_MOUSE", "mass": 13937.0, "length": 128, "protein_name": "Tachykinin-4", "gene_name": "Tac4", "organism": "Mouse", "refseq_name": "tachykinin-4 preproprotein", "refseq_ac": "NP_444323", "gene_names_uniprotkb": "Tac4", "gene_names_refseq": "PPT-C; Tac4", "protein_names_uniprotkb": "Tachykinin-4; HK-I; HK1; Hemokinin-1; Hemokinin-I; PPT-C; Preprotachykinin-C", "protein_names_refseq": "hemokinin I (HK-1); preprotachykinin-C; tachykinin-4 preproprotein", "tax_id": 10090, "disease": "", "pathway": " (mmu:93670)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11062498;11725292;11786503;12044836;12383518;12716968;12773411;12791665;12842130;15153465;15342200;15647454;16102736;17628523;23626716;25541043;27621226;34428180", "class_list": "", "function": "HK-1 influences T-cell development, enhancing the proliferation of T-cell precursors and increased the number of thymocytes in fetal thymus organ cultures, [RefSeq, PubMed]; Hemokinin-1 plays a crucial pro-inflammatory role in the lung by increasing inflammatory cell activities, and might also be a specific regulator of lymphocyte functions., [RefSeq, PubMed]; Hemokinin-1, but not substance P increases inflammation and hyperalgesia in the late phase of adjuvant-induced arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Our results provide the first evidence for an anxiolytic and anti-depressant-like actions of HK-1 through a presently unknown target-mediated mechanism, [RefSeq, PubMed]; Preprotachykinin (PPT)-C genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function., [RefSeq, PubMed]; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior. Increases sperm motility. Induces potent analgesic effects and may play a role in pain modulation. Promotes survival of bone marrow B lineage cells and of cultured LPS-stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and proliferation. Lowers systemic arterial pressure following intravenous injection. Induces interferon-gamma production and may play a role in the inflammatory response. Shows potent affinity and specificity for the NK-1 receptor., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031835 substance P receptor binding;GO:0031837 substance K receptor binding;GO:0005102 signaling receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1904057 negative regulation of sensory perception of pain;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0050965 detection of temperature stimulus involved in sensory perception of pain;GO:0051930 regulation of sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q99N14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D3P1-1", "uniprot_id": "TCHL1_MOUSE", "mass": 70707.0, "length": 638, "protein_name": "Trichohyalin-like protein 1", "gene_name": "Tchhl1", "organism": "Mouse", "refseq_name": "trichohyalin-like protein 1", "refseq_ac": "NP_082038", "gene_names_uniprotkb": "Tchhl1", "gene_names_refseq": "5430400H23Rik; S100a17; Tchhl1; Thhl1", "protein_names_uniprotkb": "Trichohyalin-like protein 1", "protein_names_refseq": "S100 calcium binding protein A17; trichohyalin-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71325)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F8VQ46", "ec_number_list": "", "go_molecular_function": "GO:0046914 transition metal ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D3P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DD24-1", "uniprot_id": "TCAL9_MOUSE", "mass": 12664.0, "length": 104, "protein_name": "Transcription elongation factor A protein-like 9", "gene_name": "Tceal9", "organism": "Mouse", "refseq_name": "transcription elongation factor A protein-like 9", "refseq_ac": "NP_035842", "gene_names_uniprotkb": "Tceal9; Wbp5", "gene_names_refseq": "Tceal9; Wbp5", "protein_names_uniprotkb": "Transcription elongation factor A protein-like 9; Schlafen 8-interacting protein; TCEA-like protein 9; Transcription elongation factor S-II protein-like 9; WBP-5; WW domain-binding protein 5", "protein_names_refseq": "TCEA-like protein 9; WBP-5; WW domain binding protein 5; schlafen 8-interacting protein; transcription elongation factor A protein-like 9; transcription elongation factor S-II protein-like 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:22381)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34428180;9171351", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KG99;O08549", "ec_number_list": "", "go_molecular_function": "GO:0050699 WW domain binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DD24-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JMB1-1", "uniprot_id": "SPMA2_MOUSE", "mass": 42796.0, "length": 375, "protein_name": "Sperm microtubule associated protein 2", "gene_name": "Spmap2", "organism": "Mouse", "refseq_name": "sperm microtubule associated protein 2 isoform 1", "refseq_ac": "NP_035713", "gene_names_uniprotkb": "Spmap2; Theg", "gene_names_refseq": "Spmap2; Theg", "protein_names_uniprotkb": "Sperm microtubule associated protein 2; Testicular haploid expressed gene protein", "protein_names_refseq": "sperm microtubule associated protein 2 isoform 1; testicular haploid expressed gene product; testicular haploid expressed gene protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:21830)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10330110;10747865;11173852;12748127", "class_list": "", "function": "Deletion of either the C-terminal or N-terminal regions of the Theg protein did not affect spermatogenesis or fertility in the mouse., [RefSeq, PubMed]; May be involved (but not essential) in spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P8H9;Q9QZ27", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JMB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P70701-1", "uniprot_id": "WN10A_MOUSE", "mass": 46454.0, "length": 417, "protein_name": "Protein Wnt-10a", "gene_name": "Wnt10a", "organism": "Mouse", "refseq_name": "protein Wnt-10a precursor", "refseq_ac": "NP_033544", "gene_names_uniprotkb": "Wnt10a", "gene_names_refseq": "Wnt10a", "protein_names_uniprotkb": "Protein Wnt-10a", "protein_names_refseq": "protein Wnt-10a precursor; protein Wnt-10a; wingless related MMTV integration site 10a", "tax_id": 10090, "disease": "tooth agenesis (Disease Ontology:DOID:0050591); Schopf-Schulz-Passarge syndrome (Disease Ontology:DOID:0111647); ectodermal dysplasia (Disease Ontology:DOID:2121)", "pathway": " (mmu:22409); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;28589954;8875992", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in normal ectoderm development. Required for normal tooth development. Required for normal postnatal development and maintenance of tongue papillae and sweat ducts. Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae. Required for normal expression of KRT9 in foot plant epithelium. Required for normal hair follicle function., [UniProtKB, PubMed]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0048733 sebaceous gland development;GO:0007165 signal transduction;GO:0007267 cell-cell signaling;GO:0010628 positive regulation of gene expression;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70701-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTR6-1", "uniprot_id": "XCT_MOUSE", "mass": 55456.0, "length": 502, "protein_name": "Cystine/glutamate transporter", "gene_name": "Slc7a11", "organism": "Mouse", "refseq_name": "cystine/glutamate transporter", "refseq_ac": "NP_036120", "gene_names_uniprotkb": "Slc7a11; sut", "gene_names_refseq": "9930009M05Rik; Slc7a11; sut; xCT", "protein_names_uniprotkb": "Cystine/glutamate transporter; Amino acid transport system xc-; Solute carrier family 7 member 11; Subtle gray protein; xCT", "protein_names_refseq": "amino acid transport system xc-; cysteine/glutamate transporter; cystine/glutamate transporter; sodium independent anionic amino acid transport system; solute carrier family 7 member 11; subtle gray protein", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); opioid abuse (Disease Ontology:DOID:11206); platelet storage pool deficiency (Disease Ontology:DOID:2223); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (mmu:26570); (R-MMU-210991); (R-MMU-352230)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;10206947;11136724;12235164;16037214;16144837;17035536;17200146;18250455;19144319;21750661;21952136;25428506;25605945;30084848;30779550;31219806;31396687;31599954;33869196;34428180;35820727;39147314;39558086;40280132", "class_list": "", "function": "Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (Probable) (PubMed:10206947, PubMed:12235164, PubMed:16037214, PubMed:16144837, PubMed:17035536). Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for protection of cells from oxidative stress (PubMed:16037214, PubMed:16144837, PubMed:17035536, PubMed:31396687). The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine (PubMed:10206947). Acts as an inhibitor of ferroptosis by mediating the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis (By similarity). Also inhibits ferroptosis by acting as an atypical proton transporter that mediates a slow proton efflux from lysosomes via cystine and glutamate flux (PubMed:40280132). Glutamate and cystine contain side-chain groups that are protonatable in the physiological range of lysosomal pH and cytosolic pH, respectively, enabling a slow lysosomal proton leak through a substrate-as-proton mechanism (By similarity). Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis (By similarity). In vitro can also transport L-aspartate (By similarity). May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons (PubMed:17035536). Controls the production of pheomelanin pigment directly (PubMed:16037214)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; P62-autophagic pathway degrades SLC7A11 to regulate ferroptosis in doxorubicin-induced cardiotoxicity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015327 cystine:glutamate antiporter activity;GO:0015252 proton channel activity;GO:0022840 leak channel activity;GO:0140926 L-kynurenine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0045177 apical part of cell;GO:0097449 astrocyte projection", "go_biological_process": "GO:1904717 regulation of AMPA glutamate receptor clustering;GO:0051223 regulation of protein transport;GO:0008542 visual learning;GO:0030534 adult behavior;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q9WTR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CX47-1", "uniprot_id": "XRCC2_MOUSE", "mass": 31391.0, "length": 278, "protein_name": "DNA repair protein XRCC2", "gene_name": "Xrcc2", "organism": "Mouse", "refseq_name": "DNA repair protein XRCC2", "refseq_ac": "NP_065595", "gene_names_uniprotkb": "Xrcc2", "gene_names_refseq": "4921524O04Rik; 8030409M04Rik; RAD51; RecA; Xrcc2", "protein_names_uniprotkb": "DNA repair protein XRCC2; X-ray repair cross-complementing protein 2", "protein_names_refseq": "DNA repair protein XRCC2; X-ray repair complementing defective repair in Chinese hamster cells 2; X-ray repair cross-complementing protein 2; recA/RAD51 family protein", "tax_id": 10090, "disease": "primary ovarian insufficiency 17 (Disease Ontology:DOID:0080874); Fanconi anemia complementation group U (Disease Ontology:DOID:0111085); spermatogenic failure 50 (Disease Ontology:DOID:0112272); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (mmu:57434); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693616)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "14678973;21750661;26300006;30042186;9628903", "class_list": "", "function": "Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA (By similarity)., [UniProtKB]; Involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms, [RefSeq, PubMed]; Order-of-magnitude higher levels of chromosomal alterations are sustained in primary or immortal Xrcc2(-/-) embryonic fibroblasts., [RefSeq, PubMed]; The homozygotes (knock-in mice with Xrcc2-c.T41C/p.Leu14Pro mutation) survived and exhibited meiotic arrest, azoospermia, premature ovarian failure and infertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88730;Q9D5T1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0000400 four-way junction DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005657 replication fork;GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex", "go_biological_process": "GO:2000269 regulation of fibroblast apoptotic process;GO:0000278 mitotic cell cycle;GO:0001701 in utero embryonic development;GO:0006281 DNA repair;GO:0010332 response to gamma radiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CX47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DFV8-1", "uniprot_id": "VWDE_MOUSE", "mass": 103786.0, "length": 926, "protein_name": "von Willebrand factor D and EGF domain-containing protein", "gene_name": "Vwde", "organism": "Mouse", "refseq_name": "von Willebrand factor D and EGF domain-containing protein isoform 2 precursor", "refseq_ac": "NP_001013779", "gene_names_uniprotkb": "Vwde; Gm467", "gene_names_refseq": "Gm467; Vwde", "protein_names_uniprotkb": "von Willebrand factor D and EGF domain-containing protein", "protein_names_refseq": "von Willebrand factor D and EGF domain-containing protein isoform 2 precursor; von Willebrand factor D and EGF domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:232585)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34957547", "class_list": "", "function": "Von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EKY3", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6DFV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TQJ8-1", "uniprot_id": "WTIP_MOUSE", "mass": 42254.0, "length": 398, "protein_name": "Wilms tumor protein 1-interacting protein", "gene_name": "Wtip", "organism": "Mouse", "refseq_name": "Wilms tumor protein 1-interacting protein", "refseq_ac": "NP_997095", "gene_names_uniprotkb": "Wtip", "gene_names_refseq": "Wtip", "protein_names_uniprotkb": "Wilms tumor protein 1-interacting protein; WT1-interacting protein", "protein_names_refseq": "Wilms tumor protein 1-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:101543); (R-MMU-1234176)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14736876;15798086;17909014;18331720;19785987;20086015;21750661;21900451;26385183", "class_list": "", "function": "Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture. In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Implicate Asxl1 in the maintenance of podocyte structure via its association with Wtip and in the regulation of WT1 signaling during early kidney development, [RefSeq, PubMed]; WTIP monitors slit diaphragm protein assembly as part of a multiple protein complex, linking this specialized adhesion junction to the actin cytoskeleton, and shuttles into the nucleus after podocyte injury, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CG89", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005925 focal adhesion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0001666 response to hypoxia;GO:0006355 regulation of DNA-templated transcription;GO:0007010 cytoskeleton organization;GO:0022604 regulation of cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7TQJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A140LHF2-1", "uniprot_id": "VSXL2_MOUSE", "mass": 83270.0, "length": 776, "protein_name": "V-set and immunoglobulin domain-containing protein 10-like 2", "gene_name": "Vsig10l2", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Vsig10l2; Gm1113", "gene_names_refseq": "", "protein_names_uniprotkb": "V-set and immunoglobulin domain-containing protein 10-like 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A140LHF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O09053-1", "uniprot_id": "WRN_MOUSE", "mass": 157204.0, "length": 1401, "protein_name": "Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN", "gene_name": "Wrn", "organism": "Mouse", "refseq_name": "bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN", "refseq_ac": "NP_001116294", "gene_names_uniprotkb": "Wrn", "gene_names_refseq": "Wrn", "protein_names_uniprotkb": "Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN; DNA 3'-5' helicase WRN; Werner syndrome protein homolog", "protein_names_refseq": "Werner syndrome ATP-dependent helicase homolog; Werner syndrome homolog; Werner syndrome protein homolog; bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN; exonuclease WRN", "tax_id": 10090, "disease": "diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); coronary artery disease (Disease Ontology:DOID:3393); restrictive cardiomyopathy (Disease Ontology:DOID:397); Werner syndrome (Disease Ontology:DOID:5688); myocardial infarction (Disease Ontology:DOID:5844); senile cataract (Disease Ontology:DOID:9669)", "pathway": " (mmu:22427); (R-MMU-174414); (R-MMU-174437); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 12, "publication_count": 12, "publication_id_list": "10757812;11301316;17229737;21750661;29494634;31219806;34418053;34428180;34772932;36210013;9143515;9618508", "class_list": "", "function": "Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity (By similarity). Has 3'->5' exonuclease activity on forked dsDNA (PubMed:17229737). Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Unwinds some G-quadruplex DNA. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; These results suggest that a great number of endoplasmic reticulum (ER) gene products are regulated at the post-transcriptional level in the liver of Wrn mutant mice exhibiting an ER stress response. Publication Status: Online-Only, [RefSeq, PubMed]; WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09050;Q80YP9;Q9JKD4;Q9Z241;Q9Z242", "ec_number_list": "3.6.4.13;3.6.4.10;3.6.4.-;5.6.2.3;5.6.2.4;2.3.2.-;2.3.2.27;3.1.13.1;5.6.2.6;3.1.-.-;7.6.2.1;3.6.1.5;3.4.24.-;3.6.-.-;3.1.3.1;3.9.1.1;3.6.1.-;5.6.2.5;4.2.99.18;3.6.4.12;5.6.1.6;3.6.4.6;3.6.5.-;3.6.1.15;3.1.4.-;5.6.2.-;7.2.2.-;7.6.2.16;3.4.21.53;2.7.7.7;2.7.7.49;2.7.11.1;2.7.4.3", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:0006979 response to oxidative stress;GO:0006284 base-excision repair;GO:0000723 telomere maintenance;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O09053-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TNA1-1", "uniprot_id": "XYLB_MOUSE", "mass": 59544.0, "length": 551, "protein_name": "Xylulose kinase", "gene_name": "Xylb", "organism": "Mouse", "refseq_name": "xylulose kinase isoform 1", "refseq_ac": "NP_001028381", "gene_names_uniprotkb": "Xylb", "gene_names_refseq": "Xylb", "protein_names_uniprotkb": "Xylulose kinase; 2.7.1.17; Xylulokinase", "protein_names_refseq": "xylulose kinase isoform 1; xylulose kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:102448); (R-MMU-5661270)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RR66;Q8R156", "ec_number_list": "2.7.1.17", "go_molecular_function": "GO:0005524 ATP binding;GO:0004856 D-xylulokinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0005997 xylulose metabolic process;GO:0042732 D-xylose metabolic process;GO:0019640 D-glucuronate catabolic process to D-xylulose 5-phosphate", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TNA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CRT8-1", "uniprot_id": "XPOT_MOUSE", "mass": 109734.0, "length": 963, "protein_name": "Exportin-T", "gene_name": "Xpot", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Xpot", "gene_names_refseq": "", "protein_names_uniprotkb": "Exportin-T; Exportin(tRNA); tRNA exportin", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:73192)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;25605945;31219806;34203471;34428180;35820727;39627609", "class_list": "", "function": "Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52KI1", "ec_number_list": "", "go_molecular_function": "GO:0000049 tRNA binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016363 nuclear matrix", "go_biological_process": "GO:0071528 tRNA re-export from nucleus;GO:0006409 tRNA export from nucleus;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CRT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3SYK4-1", "uniprot_id": "VRTN_MOUSE", "mass": 83135.0, "length": 740, "protein_name": "Vertnin", "gene_name": "Vrtn", "organism": "Mouse", "refseq_name": "vertnin", "refseq_ac": "NP_001028948", "gene_names_uniprotkb": "Vrtn", "gene_names_refseq": "7420416P09Rik; Vrtn", "protein_names_uniprotkb": "Vertnin", "protein_names_refseq": "vertebrae development homolog (pig); vertnin", "tax_id": 10090, "disease": "", "pathway": " (mmu:432677)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;29904281;36852467", "class_list": "", "function": "Acts as a transcription factor that regulates development of thoracic vertebrae., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3SYK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C761-1", "uniprot_id": "DC2I1_MOUSE", "mass": 115382.0, "length": 999, "protein_name": "Cytoplasmic dynein 2 intermediate chain 1", "gene_name": "Dync2i1", "organism": "Mouse", "refseq_name": "cytoplasmic dynein 2 intermediate chain 1", "refseq_ac": "NP_666151", "gene_names_uniprotkb": "Dync2i1; Wdr60", "gene_names_refseq": "D430033N04Rik; Dync2i1; Dync2l1; Wdr60", "protein_names_uniprotkb": "Cytoplasmic dynein 2 intermediate chain 1; Dynein 2 intermediate chain 1; WD repeat-containing protein 60", "protein_names_refseq": "WD repeat domain 60; WD repeat-containing protein 60; cytoplasmic dynein 2 intermediate chain 1", "tax_id": 10090, "disease": "short-rib thoracic dysplasia 8 with or without polydactyly (Disease Ontology:DOID:0110094)", "pathway": " (mmu:217935); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella. Also requires to maintain a functional transition zone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNM4", "ec_number_list": "", "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0036064 ciliary basal body", "go_biological_process": "GO:0060271 cilium assembly;GO:0048704 embryonic skeletal system morphogenesis;GO:0035721 intraciliary retrograde transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C761-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q14AE4-1", "uniprot_id": "WFDC3_MOUSE", "mass": 13718.0, "length": 130, "protein_name": "WAP four-disulfide core domain protein 3", "gene_name": "Wfdc3", "organism": "Mouse", "refseq_name": "WAP four-disulfide core domain protein 3 precursor", "refseq_ac": "NP_082237", "gene_names_uniprotkb": "Wfdc3; Wap14", "gene_names_refseq": "1700015L13Rik; 1700127F16Rik; Wfdc3", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 3; Putative protease inhibitor WAP14", "protein_names_refseq": "WAP four-disulfide core domain protein 3 precursor; WAP four-disulfide core domain protein 3; putative protease inhibitor WAP14", "tax_id": 10090, "disease": "", "pathway": " (mmu:71856)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q14AE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DAU7-1", "uniprot_id": "WFDC2_MOUSE", "mass": 18032.0, "length": 174, "protein_name": "WAP four-disulfide core domain protein 2", "gene_name": "Wfdc2", "organism": "Mouse", "refseq_name": "WAP four-disulfide core domain protein 2 isoform 1 precursor", "refseq_ac": "NP_080599", "gene_names_uniprotkb": "Wfdc2; He4", "gene_names_refseq": "1600023A02Rik; HE4; WAP5; Wfdc2", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 2; WAP domain-containing protein HE4", "protein_names_refseq": "WAP domain-containing protein HE4; WAP four-disulfide core domain protein 2 isoform 1 precursor; WAP four-disulfide core domain protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67701)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;21807117;31562139;31780266;37031914;38827327", "class_list": "", "function": "Causal testing implicates Wfdc2 and Hdac3 as novel genes affecting high density lipoprotein levels, [RefSeq, PubMed]; HE4 overexpression in mice leads to leydig cell hyperplasia and spermatogensis impairment: Pathological implications for oligospermia., [RefSeq, PubMed]; Knockdown of HE4 suppresses tumor growth and invasiveness in lung adenocarcinoma through regulation of EGFR signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a critical role in lung development (PubMed:31562139, PubMed:31780266). Required for terminal differentiation of bronchiole club cells (PubMed:31562139). Required for development of airway barrier mechanisms, such as lamellar body formation in type II alveolar epithelial cells and cilia formation on ciliated epithelial cells following initiation of respiration at birth (PubMed:31562139). Required for type I alveolar epithelial cell and vascular endothelial development in the lungs, thereby mediating blood-air barrier exchange (PubMed:31780266)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0019828 aspartic-type endopeptidase inhibitor activity;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:1901248 positive regulation of lung ciliated cell differentiation;GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0060426 lung vasculature development;GO:0060486 club cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DAU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A5H7-1", "uniprot_id": "WFD11_MOUSE", "mass": 9601.0, "length": 82, "protein_name": "Protein WFDC11", "gene_name": "Wfdc11", "organism": "Mouse", "refseq_name": "protein WFDC11 precursor", "refseq_ac": "NP_001155278", "gene_names_uniprotkb": "Wfdc11", "gene_names_refseq": "Wfdc11", "protein_names_uniprotkb": "Protein WFDC11", "protein_names_refseq": "protein WFDC11 precursor; protein WFDC11", "tax_id": 10090, "disease": "", "pathway": " (mmu:629761)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2A5H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A6PWY4-1", "uniprot_id": "WDR76_MOUSE", "mass": 69007.0, "length": 622, "protein_name": "WD repeat-containing protein 76", "gene_name": "Wdr76", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 76 isoform a", "refseq_ac": "NP_001277915", "gene_names_uniprotkb": "Wdr76", "gene_names_refseq": "5830411K18Rik; 6030457D09; Wdr76", "protein_names_uniprotkb": "WD repeat-containing protein 76", "protein_names_refseq": "WD repeat-containing protein 76 isoform a; WD repeat-containing protein 76", "tax_id": 10090, "disease": "", "pathway": " (mmu:241627)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "18299400;21750661;23434322;25428506;30084848;30655611;30779550;31873167;34203471;34428180;35820727", "class_list": "", "function": "Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Study identifies WD40-repeat protein 76 (WDR76) as one of the HRAS binding proteins using proteomic analyses of hepatocellular carcinomas tissue form human patients and mouse diethylnitrosamine-induced liver carcinogenesis model and demonstrates that WDR76 functions as a tumor suppressor via RAS degradation. Publication Status: Online-Only, [RefSeq, PubMed]; WDR76 mediates obesity and hepatic steatosis via HRas destabilization. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ASQ8;A4FUV0;Q504Z3;Q9CTV4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000792 heterochromatin;GO:0090734 site of DNA damage", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A6PWY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q61806-1", "uniprot_id": "XL3C_MOUSE", "mass": 26179.0, "length": 226, "protein_name": "X-linked lymphocyte-regulated protein 3C", "gene_name": "Xlr3c", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Xlr3c; Xlr3b", "gene_names_refseq": "", "protein_names_uniprotkb": "X-linked lymphocyte-regulated protein 3C; XLR-related protein A12", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:22446)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18299400;19892989;21750661;21952136;7821804", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61244", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007286 spermatid development;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61806-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80W47-1", "uniprot_id": "WIPI2_MOUSE", "mass": 48477.0, "length": 445, "protein_name": "WD repeat domain phosphoinositide-interacting protein 2", "gene_name": "Wipi2", "organism": "Mouse", "refseq_name": "WD repeat domain phosphoinositide-interacting protein 2 isoform 1", "refseq_ac": "NP_848485", "gene_names_uniprotkb": "Wipi2", "gene_names_refseq": "1110018O08Rik; 2510001I10Rik; Wipi2", "protein_names_uniprotkb": "WD repeat domain phosphoinositide-interacting protein 2; WIPI-2", "protein_names_refseq": "WD repeat domain phosphoinositide-interacting protein 2 isoform 1; WD repeat domain phosphoinositide-interacting protein 2; WIPI-2", "tax_id": 10090, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:74781); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "17242355;18299400;20173027;21750661;21952136;23051912;23291478;24954904;25428506;25428507;28135057;28528544;29187734;30084848;30340022;31219806;31309927;31794336;32152506;33649389;34428180;37828378", "class_list": "", "function": "Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:23051912, PubMed:23291478, PubMed:24954904). Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (By similarity). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Importantly, ectopically expressing WIPI2B effectively restored autophagosome biogenesis in aged neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0030674 protein-macromolecule adaptor activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0034497 protein localization to phagophore assembly site;GO:0061739 protein lipidation involved in autophagosome assembly;GO:0098792 xenophagy;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q80W47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D3YX43-1", "uniprot_id": "VSI10_MOUSE", "mass": 60522.0, "length": 558, "protein_name": "V-set and immunoglobulin domain-containing protein 10", "gene_name": "Vsig10", "organism": "Mouse", "refseq_name": "V-set and immunoglobulin domain-containing protein 10 precursor", "refseq_ac": "NP_001028483", "gene_names_uniprotkb": "Vsig10", "gene_names_refseq": "Vsig10", "protein_names_uniprotkb": "V-set and immunoglobulin domain-containing protein 10", "protein_names_refseq": "V-set and immunoglobulin domain-containing protein 10 precursor; V-set and immunoglobulin domain-containing protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:231668)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806;37828378", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0043005 neuron projection", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "D3YX43-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJA4-1", "uniprot_id": "WDR12_MOUSE", "mass": 47347.0, "length": 423, "protein_name": "Ribosome biogenesis protein WDR12", "gene_name": "Wdr12", "organism": "Mouse", "refseq_name": "ribosome biogenesis protein WDR12", "refseq_ac": "NP_001185989", "gene_names_uniprotkb": "Wdr12; MNCb-5414", "gene_names_refseq": "4933402C23Rik; Wdr12; Ytm1p; Ytm1", "protein_names_uniprotkb": "Ribosome biogenesis protein WDR12; WD repeat-containing protein 12", "protein_names_refseq": "WD repeat-containing protein 12; nuclear protein Ytm1; ribosome biogenesis protein WDR12", "tax_id": 10090, "disease": "", "pathway": " (mmu:57750); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11827460;21750661;24788674;31219806;34428180;36210013;38795544", "class_list": "", "function": "Amino-terminal similarity to Notchless WD repeat protein. May function in the modulation of Notch signaling activity., [RefSeq, PubMed]; CircMIRIAF aggravates myocardial ischemia-reperfusion injury via targeting miR-544/WDR12 axis., [RefSeq, PubMed]; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CST3;Q9JKF5", "ec_number_list": "", "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0070545 PeBoW complex", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0051726 regulation of cell cycle;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JJA4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9R0D8-1", "uniprot_id": "WDR54_MOUSE", "mass": 35613.0, "length": 334, "protein_name": "WD repeat-containing protein 54", "gene_name": "Wdr54", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 54 isoform a", "refseq_ac": "NP_076279", "gene_names_uniprotkb": "Wdr54; D3Mm3e", "gene_names_refseq": "1700030E05Rik; Wdr54", "protein_names_uniprotkb": "WD repeat-containing protein 54", "protein_names_refseq": "WD repeat-containing protein 54 isoform a; WD repeat-containing protein 54", "tax_id": 10090, "disease": "", "pathway": " (mmu:75659)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;31219806;34428180;9806835", "class_list": "", "function": "Plays a role in the adhesion and fusion of the sperm-oocyte membrane through its interactions with IZUMO1 and IZUMO1R/JUNO. When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4A4", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031514 motile cilium;GO:0031982 vesicle", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0007338 single fertilization;GO:0002091 negative regulation of receptor internalization;GO:0043408 regulation of MAPK cascade;GO:0042058 regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R0D8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D4PHA7-1", "uniprot_id": "WSCD2_MOUSE", "mass": 64598.0, "length": 571, "protein_name": "Sialate:O-sulfotransferase 2", "gene_name": "Wscd2", "organism": "Mouse", "refseq_name": "sialate:O-sulfotransferase 2", "refseq_ac": "NP_796266", "gene_names_uniprotkb": "Wscd2; Kiaa0789", "gene_names_refseq": "4933413A10Rik; C530024P05Rik; Gm450; Wscd2", "protein_names_uniprotkb": "Sialate:O-sulfotransferase 2; WSC domain-containing protein 2", "protein_names_refseq": "WSC domain-containing protein 2; sialate:O-sulfotransferase 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:320916)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;35864127", "class_list": "", "function": "Sialate:O-sulfotransferase that catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. Displays selectivity toward glycoproteins such as TF/transferrin., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZZ2;Q8C7Q3", "ec_number_list": "", "go_molecular_function": "GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D4PHA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9PYY5-1", "uniprot_id": "DNAI4_MOUSE", "mass": 90173.0, "length": 807, "protein_name": "Dynein axonemal intermediate chain 4", "gene_name": "Dnai4", "organism": "Mouse", "refseq_name": "dynein axonemal intermediate chain 4 isoform 1", "refseq_ac": "NP_666366", "gene_names_uniprotkb": "Dnai4; Wdr78", "gene_names_refseq": "Dnai4; Wdr78", "protein_names_uniprotkb": "Dynein axonemal intermediate chain 4; WD repeat-containing protein 78", "protein_names_refseq": "WD repeat domain 78; WD repeat-containing protein 78; dynein axonemal intermediate chain 4 isoform 1; dynein intermediate chain 4, axonemal", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340)", "pathway": " (mmu:242584)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30060180;35820727", "class_list": "", "function": "Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility., [UniProtKB, PubMed]; Wdr78 associated with Dynein-f subunits such as Dnah2 (a HC) and Wdr63 (IC140 orthologue). It was expressed as a motile cilium-specific protein in mammalian cells. Depletion of Wdr78 or Dnah2 by RNAi paralyzed mouse ependymal cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0I9;Q8K042;Q8K111", "ec_number_list": "", "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0031514 motile cilium;GO:0005930 axoneme;GO:0005858 axonemal dynein complex;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation;GO:0003341 cilium movement;GO:0070286 axonemal dynein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9PYY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR39-1", "uniprot_id": "WIPI3_MOUSE", "mass": 38021.0, "length": 344, "protein_name": "WD repeat domain phosphoinositide-interacting protein 3", "gene_name": "Wdr45b", "organism": "Mouse", "refseq_name": "WD repeat domain phosphoinositide-interacting protein 3", "refseq_ac": "NP_080069", "gene_names_uniprotkb": "Wdr45b; Wdr45l; Wipi3", "gene_names_refseq": "0610008N23Rik; D16Bwg0193e; WIPI-3; Wdr45b; Wdr45l", "protein_names_uniprotkb": "WD repeat domain phosphoinositide-interacting protein 3; WD repeat-containing protein 45-like; WD repeat-containing protein 45B; WDR45-like protein; WIPI-3", "protein_names_refseq": "WD repeat domain phosphoinositide-interacting protein 3; WD repeat-containing protein 45-like; WD repeat-containing protein 45B; WDR45-like protein; Wdr45 like", "tax_id": 10090, "disease": "", "pathway": " (mmu:66840); (R-MMU-1632852)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;28528544;28561066;33082312", "class_list": "", "function": "Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2. In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway., [UniProtKB, UniProtKB]; Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U924", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0062078 TSC1-TSC2 complex binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005764 lysosome;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0034497 protein localization to phagophore assembly site;GO:0009267 cellular response to starvation;GO:0000422 autophagy of mitochondrion;GO:0044804 nucleophagy", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CR39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F6ULY1-1", "uniprot_id": "WFC6B_MOUSE", "mass": 17169.0, "length": 148, "protein_name": "WAP four-disulfide core domain protein 6B", "gene_name": "Wfdc6b", "organism": "Mouse", "refseq_name": "WAP four-disulfide core domain protein 6B precursor", "refseq_ac": "NP_001012743", "gene_names_uniprotkb": "Wfdc6b; Wfdc6", "gene_names_refseq": "WAP6b; Wfdc6b; Wfdc6", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 6B; Putative protease inhibitor WAP6B", "protein_names_refseq": "WAP four-disulfide core 6-like 1; WAP four-disulfide core domain protein 6B precursor; WAP four-disulfide core domain protein 6B; putative protease inhibitor WAP6B", "tax_id": 10090, "disease": "", "pathway": " (mmu:433502)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15950183", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RUM4;E9Q6A8;Q5DQU6", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1901318 negative regulation of flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F6ULY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q811B1-1", "uniprot_id": "XYLT1_MOUSE", "mass": 107298.0, "length": 953, "protein_name": "Xylosyltransferase 1", "gene_name": "Xylt1", "organism": "Mouse", "refseq_name": "xylosyltransferase 1", "refseq_ac": "NP_783576", "gene_names_uniprotkb": "Xylt1", "gene_names_refseq": "8030490L12; Xylt1", "protein_names_uniprotkb": "Xylosyltransferase 1; 2.4.2.26; Peptide O-xylosyltransferase 1; Xylosyltransferase I", "protein_names_refseq": "peptide O-xylosyltransferase 1; xylosyltransferase 1; xylosyltransferase I", "tax_id": 10090, "disease": "Desbuquois dysplasia (Disease Ontology:DOID:0060462); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); kidney disease (Disease Ontology:DOID:557); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:233781); (R-MMU-1971475)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11099377;15461586;17189265;17517600;21750661;24161523;25428506;29187734;30084848;32965647", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal maturation of chondrocytes during bone development, normal onset of ossification and normal embryonic and postnatal skeleton development, especially of the long bones., [UniProtKB, PubMed]; Xylosyltransferase 2 deficiency and organ homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 48, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9EPL1", "ec_number_list": "2.4.2.26", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030158 protein xylosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0000137 Golgi cis cisterna", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0034605 cellular response to heat;GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q811B1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC51-1", "uniprot_id": "TCAB1_MOUSE", "mass": 58151.0, "length": 532, "protein_name": "Telomerase Cajal body protein 1", "gene_name": "Wrap53", "organism": "Mouse", "refseq_name": "telomerase Cajal body protein 1", "refseq_ac": "NP_659073", "gene_names_uniprotkb": "Wrap53; Tcab1; Wdr79", "gene_names_refseq": "Wdr79; Wrap53", "protein_names_uniprotkb": "Telomerase Cajal body protein 1; WD repeat-containing protein 79; WD40 repeat-containing protein antisense to TP53 gene homolog", "protein_names_refseq": "WD repeat containing, antisense to TP53; WD repeat domain 79; WD repeat-containing protein 79; WD repeat-containing protein WRAP53; WD40 repeat-containing protein antisense to TP53 gene homolog; WD40 repeat-containing protein encoded by RNA antisense to p53; telomerase Cajal body protein 1", "tax_id": 10090, "disease": "autosomal recessive dyskeratosis congenita 3 (Disease Ontology:DOID:0070019); breast cancer (Disease Ontology:DOID:1612); rectal benign neoplasm (Disease Ontology:DOID:1984); motor neuron disease (Disease Ontology:DOID:231); ovarian cancer (Disease Ontology:DOID:2394); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); glottis squamous cell carcinoma (Disease Ontology:DOID:7031); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:216853); (R-MMU-171319); (R-MMU-174430)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;26849396;29804836", "class_list": "", "function": "Overexpression of WDR79 in non-small cell lung cancer is linked to tumor progression., [RefSeq, PubMed]; RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (By similarity). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (By similarity). In addition, also controls telomerase holoenzyme complex localization to Cajal body (By similarity). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (By similarity). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (By similarity). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (By similarity). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0035861 site of double-strand break;GO:0015030 Cajal body", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0090666 scaRNA localization to Cajal body;GO:0034337 RNA folding;GO:0032203 telomere formation via telomerase;GO:0090671 telomerase RNA localization to Cajal body", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VC51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62810-1", "uniprot_id": "WFD18_MOUSE", "mass": 7787.0, "length": 74, "protein_name": "WAP four-disulfide core domain protein 18", "gene_name": "Wfdc18", "organism": "Mouse", "refseq_name": "WAP four-disulfide core domain protein 18 precursor", "refseq_ac": "NP_031995", "gene_names_uniprotkb": "Wfdc18; Expi; Wdnm1", "gene_names_refseq": "Expi; Kal1; WDNM1; Wfdc18", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 18; Extracellular peptidase inhibitor; Protein WDNM1", "protein_names_refseq": "Kallmann syndrome 1 sequence; WAP four-disulfide core domain protein 18 precursor; WAP four-disulfide core domain protein 18; extracellular peptidase inhibitor; extracellular proteinase inhibitor", "tax_id": 10090, "disease": "", "pathway": " (mmu:14038)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;7970700", "class_list": "", "function": "Could have proteinase inhibiting capacity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62477;Q91VQ6", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62810-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13372-1", "uniprot_id": "VPB1A_MOUSE", "mass": 16125.0, "length": 142, "protein_name": "Immunoglobulin iota chain", "gene_name": "Vpreb1a", "organism": "Mouse", "refseq_name": "immunoglobulin iota chain precursor", "refseq_ac": "NP_058678", "gene_names_uniprotkb": "Vpreb1a; Vpreb1", "gene_names_refseq": "CD179a; Vpreb-1; Vpreb1a; Vpreb1", "protein_names_uniprotkb": "Immunoglobulin iota chain; Protein VPreB1; V-set pre-B cell surrogate light chain 1A", "protein_names_refseq": "immunoglobulin iota chain precursor; immunoglobulin iota chain; pre-B lymphocyte gene 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22362)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22566564;25523463;29907570;3117530", "class_list": "", "function": "Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation., [UniProtKB]; Data show no autoantibody production was detectable in surrogate light chain (SLC) components VpreB/CD179a and lambda5/CD179b transgenic mice., [RefSeq, PubMed]; VpreB probes the fitness of newly generated VH domains of IgH chains for later pairing with IgL chains, and its non-Ig part fixes the preBCRs on the surface., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0000902 cell morphogenesis;GO:0030097 hemopoiesis;GO:0001782 B cell homeostasis;GO:0048872 homeostasis of number of cells", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P13372-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21552-1", "uniprot_id": "WNT2_MOUSE", "mass": 40482.0, "length": 360, "protein_name": "Protein Wnt-2", "gene_name": "Wnt2", "organism": "Mouse", "refseq_name": "protein Wnt-2 precursor", "refseq_ac": "NP_076142", "gene_names_uniprotkb": "Wnt2; Irp; Wnt-2", "gene_names_refseq": "2610510E18Rik; Int1l1; Irp; Mirp; Wnt-2; Wnt2a; Wnt2", "protein_names_uniprotkb": "Protein Wnt-2; INT-1-related protein; IRP", "protein_names_refseq": "INT-1-related protein; protein Wnt-2 precursor; protein Wnt-2; wingless-related MMTV integration site 2", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); endometrial carcinoma (Disease Ontology:DOID:2871); breast carcinoma (Disease Ontology:DOID:3459); urinary system cancer (Disease Ontology:DOID:3996); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:22413); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "19686689;20018874;21704027;2279700;2693041", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:19686689). Functions as a upstream regulator of FGF10 expression (PubMed:19686689). Plays an important role in embryonic lung development (PubMed:19686689). May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (PubMed:20018874)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZW3", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001938 positive regulation of endothelial cell proliferation;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P21552-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22727-1", "uniprot_id": "WNT6_MOUSE", "mass": 39656.0, "length": 364, "protein_name": "Protein Wnt-6", "gene_name": "Wnt6", "organism": "Mouse", "refseq_name": "protein Wnt-6 precursor", "refseq_ac": "NP_033552", "gene_names_uniprotkb": "Wnt6; Wnt-6", "gene_names_refseq": "Wnt-6; Wnt6", "protein_names_uniprotkb": "Protein Wnt-6", "protein_names_refseq": "protein Wnt-6 precursor; protein Wnt-6; wingless-related MMTV integration site 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:22420); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10866835;22370641;2279700;31219806", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZM9", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0009798 axis specification;GO:0007165 signal transduction;GO:0007267 cell-cell signaling;GO:0010628 positive regulation of gene expression;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P22727-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24383-1", "uniprot_id": "WNT7A_MOUSE", "mass": 38974.0, "length": 349, "protein_name": "Protein Wnt-7a", "gene_name": "Wnt7a", "organism": "Mouse", "refseq_name": "protein Wnt-7a isoform 1 precursor", "refseq_ac": "NP_033553", "gene_names_uniprotkb": "Wnt7a; Wnt-7a", "gene_names_refseq": "Wnt-7a; Wnt7a; px; tw", "protein_names_uniprotkb": "Protein Wnt-7a", "protein_names_refseq": "postaxial hemimelia; protein Wnt-7a isoform 1 precursor; protein Wnt-7a; wingless-related MMTV integration site 7A", "tax_id": 10090, "disease": "Fuhrmann syndrome (Disease Ontology:DOID:0090067); Schinzel type phocomelia (Disease Ontology:DOID:0112181); leiomyoma (Disease Ontology:DOID:127)", "pathway": " (mmu:22421); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10866835;18230341;20530549;2279700;23629626;28803732;7885472;9769174;9790192", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:18230341, PubMed:20530549, PubMed:23629626). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:7885472, PubMed:9769174, PubMed:9790192). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:28803732). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (PubMed:9790192). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (PubMed:23629626). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (PubMed:23629626). Promotes formation of synapses via its interaction with FZD5 (PubMed:20530549)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80VH3;Q9DBY3", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0000578 embryonic axis specification;GO:0060856 establishment of blood-brain barrier;GO:0001525 angiogenesis;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P24383-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62761-1", "uniprot_id": "VISL1_MOUSE", "mass": 22142.0, "length": 191, "protein_name": "Visinin-like protein 1", "gene_name": "Vsnl1", "organism": "Mouse", "refseq_name": "visinin-like protein 1", "refseq_ac": "NP_036168", "gene_names_uniprotkb": "Vsnl1; Visl1", "gene_names_refseq": "VILIP; Vnsl1; Vsnl1", "protein_names_uniprotkb": "Visinin-like protein 1; NVL-1; NVP-1; Neural visinin-like protein 1; VILIP", "protein_names_refseq": "NVL-1; NVP-1; neural visinin-like protein 1; visinin-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:26950)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15735716;31712124;33300544", "class_list": "", "function": "Decreased or absent VILIP-1 expression in SCC cell subpopulations may lead to a more advanced malignant phenotype characterized by changes in adhesive ability and increased cell motility, suggestive of a tumor suppressor function, [RefSeq, PubMed]; Our results demonstrated that...Helios has a specific and important role for a correct function of hippocampal calbindin-positive CA1 pyramidal neurons regulating spinogenesis...and that Visinin-like protein 1 (VSNL1) could play an important role in such processes, [RefSeq, PubMed]; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P28677;P29103;P42323;Q9UM20", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0046676 negative regulation of insulin secretion;GO:0009966 regulation of signal transduction;GO:0045921 positive regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62761-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P97946-1", "uniprot_id": "VEGFD_MOUSE", "mass": 40909.0, "length": 358, "protein_name": "Vascular endothelial growth factor D", "gene_name": "Vegfd", "organism": "Mouse", "refseq_name": "vascular endothelial growth factor D isoform VEGF-D326 preproprotein", "refseq_ac": "NP_001295418", "gene_names_uniprotkb": "Vegfd; Figf", "gene_names_refseq": "Figf; VEGF-D; Vegfd", "protein_names_uniprotkb": "Vascular endothelial growth factor D; FIGF; VEGF-D; c-Fos-induced growth factor", "protein_names_refseq": "c-fos induced growth factor; vascular endothelial growth factor D isoform VEGF-D326 preproprotein", "tax_id": 10090, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); ovarian carcinoma (Disease Ontology:DOID:4001); pancreatic intraductal papillary-mucinous neoplasm (Disease Ontology:DOID:7575)", "pathway": " (mmu:14205); (R-MMU-114608); (R-MMU-194313); (R-MMU-195399)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11279005;31219806;8876195;9205122;9622638", "class_list": "", "function": "Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor., [UniProtKB]; This gene encodes a member of the vascular endothelial growth factor (VEGF) family that acts as a ligand for vascular endothelial growth factor receptor 3. Signalling through this protein is important for growth and development of endothelial and vascular tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2AIH3", "ec_number_list": "", "go_molecular_function": "GO:0043185 vascular endothelial growth factor receptor 3 binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0008083 growth factor activity;GO:0005172 vascular endothelial growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0008283 cell population proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0001666 response to hypoxia;GO:0032755 positive regulation of interleukin-6 production;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97946-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TNU4-1", "uniprot_id": "YD021_MOUSE", "mass": 66631.0, "length": 584, "protein_name": "Putative uncharacterized protein ENSP00000382790 homolog", "gene_name": "Gm3414", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Gm3414", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative uncharacterized protein ENSP00000382790 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3TNU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UW41-1", "uniprot_id": "WFDC9_MOUSE", "mass": 9564.0, "length": 83, "protein_name": "Protein WFDC9", "gene_name": "Wfdc9", "organism": "Mouse", "refseq_name": "protein WFDC9 precursor", "refseq_ac": "NP_001153886", "gene_names_uniprotkb": "Wfdc9", "gene_names_refseq": "Wfdc9", "protein_names_uniprotkb": "Protein WFDC9", "protein_names_refseq": "protein WFDC9 precursor; protein WFDC9", "tax_id": 10090, "disease": "", "pathway": " (mmu:629754)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UW41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3UW55-1", "uniprot_id": "WFC6A_MOUSE", "mass": 15903.0, "length": 136, "protein_name": "WAP four-disulfide core domain protein 6A", "gene_name": "Wfdc6a", "organism": "Mouse", "refseq_name": "WAP four-disulfide core domain protein 6A isoform 2 precursor", "refseq_ac": "NP_001028412", "gene_names_uniprotkb": "Wfdc6a; Gm122", "gene_names_refseq": "Gm122; Wfdc6a", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 6A; Putative protease inhibitor WAP6A", "protein_names_refseq": "WAP four-disulfide core domain protein 6A isoform 2 precursor; WAP four-disulfide core domain protein 6A; likely orthologue of H. sapiens WAP four-disulfide core domain 6 (WFDC6); putative protease inhibitor WAP6A", "tax_id": 10090, "disease": "", "pathway": " (mmu:209351)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1901318 negative regulation of flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UW55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KUS1-1", "uniprot_id": "WFDC8_MOUSE", "mass": 31279.0, "length": 273, "protein_name": "WAP four-disulfide core domain protein 8", "gene_name": "Wfdc8", "organism": "Mouse", "refseq_name": "WAP four-disulfide core domain protein 8 isoform 2", "refseq_ac": "NP_001074019", "gene_names_uniprotkb": "Wfdc8; Gm706", "gene_names_refseq": "Gm706; Wfdc8", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 8; Putative protease inhibitor WAP8C", "protein_names_refseq": "WAP four-disulfide core domain protein 8 isoform 2; WAP four-disulfide core domain protein 8; WAP-type serine protease inhibitor; putative protease inhibitor WAP8C", "tax_id": 10090, "disease": "", "pathway": " (mmu:277343)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;15950183;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4KUS1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5GH64-1", "uniprot_id": "XKR7_MOUSE", "mass": 64302.0, "length": 580, "protein_name": "XK-related protein 7", "gene_name": "Xkr7", "organism": "Mouse", "refseq_name": "XK-related protein 7", "refseq_ac": "NP_001011732", "gene_names_uniprotkb": "Xkr7; 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Xrcc-1", "gene_names_refseq": "Xrcc-1; Xrcc1", "protein_names_uniprotkb": "DNA repair protein XRCC1; X-ray repair cross-complementing protein 1", "protein_names_refseq": "DNA repair protein XRCC1 isoform 1; DNA repair protein XRCC1; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); myelodysplastic syndrome (Disease Ontology:DOID:0050908); brain glioma (Disease Ontology:DOID:0060108); colorectal carcinoma (Disease Ontology:DOID:0080199); autosomal recessive spinocerebellar ataxia 26 (Disease Ontology:DOID:0080260); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); hepatitis A (Disease Ontology:DOID:12549); leiomyoma (Disease Ontology:DOID:127); lung cancer (Disease Ontology:DOID:1324); malignant mesothelioma (Disease Ontology:DOID:1790); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); hepatitis B (Disease Ontology:DOID:2043); transient cerebral ischemia (Disease Ontology:DOID:224); laryngeal carcinoma (Disease Ontology:DOID:2600); transitional cell carcinoma (Disease Ontology:DOID:2671); contact dermatitis (Disease Ontology:DOID:2773); invasive ductal carcinoma (Disease Ontology:DOID:3008); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); gallbladder cancer (Disease Ontology:DOID:3121); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); meningioma (Disease Ontology:DOID:3565); liver cancer (Disease Ontology:DOID:3571); central nervous system cancer (Disease Ontology:DOID:3620); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); cervical cancer (Disease Ontology:DOID:4362); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); stomach carcinoma (Disease Ontology:DOID:5517); gastric cardia carcinoma (Disease Ontology:DOID:6270); gastric cardia adenocarcinoma (Disease Ontology:DOID:6271); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); in situ carcinoma (Disease Ontology:DOID:8719); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:22594); (R-MMU-110381); (R-MMU-5649702); (R-MMU-5685939); (R-MMU-6782210)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "17242355;19131326;21183079;28002403;31043584;36702010;39627609;7959765", "class_list": "", "function": "Polbeta/XRCC1 heterodimerization dictates DNA damage recognition and basal Polbeta protein levels without interfering with mouse viability or fertility., [RefSeq, PubMed]; SIRT1 confers chemoresistance to lung cancer cells by deacetylating and stabilizing XRCC1. Publication Status: Online-Only, [RefSeq, PubMed]; Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (By similarity). Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:28002403). Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 52, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3THC5;Q5U435;Q7TNQ5", "ec_number_list": "", "go_molecular_function": "GO:0072572 poly-ADP-D-ribose binding;GO:0019899 enzyme binding;GO:1990165 single-strand break-containing DNA binding;GO:0032356 oxidized DNA binding;GO:0160002 ADP-D-ribose modification-dependent protein binding", "go_cellular_component": "GO:0070522 ERCC4-ERCC1 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0061819 telomeric DNA-containing double minutes formation;GO:1905765 negative regulation of protection from non-homologous end joining at telomere;GO:0006281 DNA repair;GO:0006284 base-excision repair;GO:0021766 hippocampus development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q60596-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62471-1", "uniprot_id": "VNS1_MOUSE", "mass": 20626.0, "length": 182, "protein_name": "Vomeronasal secretory protein 1", "gene_name": "Lcn3", "organism": "Mouse", "refseq_name": "vomeronasal secretory protein 1 precursor", "refseq_ac": "NP_034824", "gene_names_uniprotkb": "Lcn3", "gene_names_refseq": "Lcn3; Vnsp1", "protein_names_uniprotkb": "Vomeronasal secretory protein 1; Lipocalin-3; VNSP I; Vomeronasal secretory protein I", "protein_names_refseq": "VNSP I; vomeronasal secretory protein 1 precursor; vomeronasal secretory protein 1; vomeronasal secretory protein I", "tax_id": 10090, "disease": "", "pathway": " (mmu:16820)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20173027;7813422", "class_list": "", "function": "Transport of lipophilic molecules, possible pheromone-carrier., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0036094 small molecule binding;GO:0005550 pheromone binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62471-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62472-1", "uniprot_id": "VNS2_MOUSE", "mass": 21399.0, "length": 185, "protein_name": "Vomeronasal secretory protein 2", "gene_name": "Lcn4", "organism": "Mouse", "refseq_name": "vomeronasal secretory protein 2 precursor", "refseq_ac": "NP_034825", "gene_names_uniprotkb": "Lcn4", "gene_names_refseq": "A630045M08Rik; Lcn4; Vnsp2", "protein_names_uniprotkb": "Vomeronasal secretory protein 2; Lipocalin-4; VNSP II; Vomeronasal secretory protein II", "protein_names_refseq": "VNSP II; vomeronasal secretory protein 2 precursor; vomeronasal secretory protein 2; vomeronasal secretory protein II", "tax_id": 10090, "disease": "", "pathway": " (mmu:16821)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7813422", "class_list": "", "function": "Transport of lipophilic molecules, possible pheromone-carrier., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0036094 small molecule binding;GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62472-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62481-1", "uniprot_id": "VPS72_MOUSE", "mass": 40784.0, "length": 368, "protein_name": "Vacuolar protein sorting-associated protein 72 homolog", "gene_name": "Vps72", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 72 homolog", "refseq_ac": "NP_033362", "gene_names_uniprotkb": "Vps72; Tcfl1; Yl1", "gene_names_refseq": "Tcfl1; Vps72; YL-1", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 72 homolog; Protein YL-1; Transcription factor-like 1", "protein_names_refseq": "protein YL-1; transcription factor-like 1; vacuolar protein sorting-associated protein 72 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:21427)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "30842416;34428180;7702631", "class_list": "", "function": "Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling., [UniProtKB, UniProtKB]; Znhit1 promotes the interaction between H2A.Z and YL1 (H2A.Z chaperone) by controlling YL1 phosphorylation. These results demonstrate that Znhit1/H2A.Z is essential for Lgr5+ stem cell maintenance and intestinal homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2N4;Q810A9;Q99K81", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042393 histone binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0016607 nuclear speck;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex;GO:0032991 protein-containing complex;GO:0000786 nucleosome", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0042981 regulation of apoptotic process;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62481-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q64527-1", "uniprot_id": "WNT8A_MOUSE", "mass": 39573.0, "length": 354, "protein_name": "Protein Wnt-8a", "gene_name": "Wnt8a", "organism": "Mouse", "refseq_name": "protein Wnt-8a precursor", "refseq_ac": "NP_033316", "gene_names_uniprotkb": "Wnt8a; Stra11; Wnt8d", "gene_names_refseq": "Stra11; Wnt-8A; Wnt-8D; Wnt8a; Wnt8d", "protein_names_uniprotkb": "Protein Wnt-8a; Protein Wnt-8d; Stimulated by retinoic acid gene 11 protein", "protein_names_refseq": "protein Wnt-8a precursor; protein Wnt-8a; protein Wnt-8d; stimulated by retinoic acid gene 11 protein; wingless-related MMTV integration site 8A; wingless-related MMTV integration site 8D; wnt-8", "tax_id": 10090, "disease": "", "pathway": " (mmu:20890); (R-MMU-3238698); (R-MMU-4641262)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "33687475;8887323", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning., [UniProtKB, UniProtKB]; LncRNA Ttc3-209 Promotes the Apoptosis of Retinal Ganglion Cells in Retinal Ischemia Reperfusion Injury by Targeting the miR-484/Wnt8a Axis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QL90", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0048561 establishment of animal organ orientation;GO:0009949 polarity specification of anterior/posterior axis;GO:0000902 cell morphogenesis;GO:0032880 regulation of protein localization;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64527-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6P205-1", "uniprot_id": "XL3B_MOUSE", "mass": 26147.0, "length": 226, "protein_name": "X-linked lymphocyte-regulated protein 3B", "gene_name": "Xlr3b", "organism": "Mouse", "refseq_name": "X-linked lymphocyte-regulated protein 3B isoform 1", "refseq_ac": "NP_001075112", "gene_names_uniprotkb": "Xlr3b", "gene_names_refseq": "EG574437; Xlr3b; Xlr3", "protein_names_uniprotkb": "X-linked lymphocyte-regulated protein 3B", "protein_names_refseq": "X-linked lymphocyte-regulated protein 3B isoform 1; X-linked lymphocyte-regulated protein 3B", "tax_id": 10090, "disease": "", "pathway": " (mmu:574437)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007286 spermatid development;GO:0051965 positive regulation of synapse assembly;GO:0061003 positive regulation of dendritic spine morphogenesis;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P205-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810I0-1", "uniprot_id": "VP37D_MOUSE", "mass": 28563.0, "length": 261, "protein_name": "Vacuolar protein sorting-associated protein 37D", "gene_name": "Vps37d", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 37D isoform 1", "refseq_ac": "NP_001186606", "gene_names_uniprotkb": "Vps37d; Wbscr24", "gene_names_refseq": "Vps37d; Wbscr24", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 37D; ESCRT-I complex subunit VPS37D; Williams-Beuren syndrome region protein 24 homolog", "protein_names_refseq": "ESCRT-I complex subunit VPS37D; Williams-Beuren syndrome chromosome region 24 homolog; Williams-Beuren syndrome critical region protein 24; vacuolar protein sorting-associated protein 37D isoform 1; vacuolar protein sorting-associated protein 37D; williams-Beuren syndrome region protein 24 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:194309); (R-MMU-917729)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80UX4;Q8C1V8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031902 late endosome membrane;GO:0000813 ESCRT I complex", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0006623 protein targeting to vacuole;GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q810I0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BH89-1", "uniprot_id": "WF15A_MOUSE", "mass": 9062.0, "length": 80, "protein_name": "WAP four-disulfide core domain protein 15A", "gene_name": "Wfdc15a", "organism": "Mouse", "refseq_name": "WAP four-disulfide core domain protein 15A precursor", "refseq_ac": "NP_899094", "gene_names_uniprotkb": "Wfdc15a", "gene_names_refseq": "1700049M11Rik; Wfdc15a; Wfdcl1", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 15A", "protein_names_refseq": "WAP four-disulfide core domain protein 15A precursor; WAP four-disulfide core domain protein 15A", "tax_id": 10090, "disease": "", "pathway": " (mmu:68221)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15950183", "class_list": "", "function": "Antibacterial protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BH89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BRU6-1", "uniprot_id": "VMAT2_MOUSE", "mass": 55754.0, "length": 517, "protein_name": "Synaptic vesicular amine transporter", "gene_name": "Slc18a2", "organism": "Mouse", "refseq_name": "synaptic vesicular amine transporter", "refseq_ac": "NP_766111", "gene_names_uniprotkb": "Slc18a2; Vmat2", "gene_names_refseq": "1110037L13Rik; 9330105E13; Slc18a2; Vmat2", "protein_names_uniprotkb": "Synaptic vesicular amine transporter; Monoamine transporter; Solute carrier family 18 member 2; VAT2; Vesicular amine transporter 2; Vesicular monoamine transporter 2", "protein_names_refseq": "VAT2; solute carrier family 18 member 2; synaptic vesicular amine transporter; vesicular amine transporter 2; vesicular monoamine transporter 2", "tax_id": 10090, "disease": "infantile parkinsonism-dystonia 2 (Disease Ontology:DOID:0070490); Parkinson's disease (Disease Ontology:DOID:14330); Machado-Joseph disease (Disease Ontology:DOID:1440); anxiety disorder (Disease Ontology:DOID:2030); substance-related disorder (Disease Ontology:DOID:303); toxic encephalopathy (Disease Ontology:DOID:3602); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:214084); (R-MMU-181429); (R-MMU-181430); (R-MMU-212676)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10618388;19357284;33300544;37907739;9427251", "class_list": "", "function": "Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (By similarity) (PubMed:10618388). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (PubMed:9427251). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (By similarity) (PubMed:10618388)., [UniProtKB, UniProtKB, PubMed, PubMed]; PLCgamma1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8CC55", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0031072 heat shock protein binding;GO:0005275 amine transmembrane transporter activity;GO:0005335 serotonin:sodium:chloride symporter activity;GO:1901363 heterocyclic compound binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005813 centrosome;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0015844 monoamine transport;GO:0007626 locomotory behavior;GO:0001975 response to amphetamine;GO:0071466 cellular response to xenobiotic stimulus;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BRU6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BZZ3-1", "uniprot_id": "WWP1_MOUSE", "mass": 104694.0, "length": 918, "protein_name": "NEDD4-like E3 ubiquitin-protein ligase WWP1", "gene_name": "Wwp1", "organism": "Mouse", "refseq_name": "NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform 2", "refseq_ac": "NP_001263221", "gene_names_uniprotkb": "Wwp1", "gene_names_refseq": "8030445B08Rik; AIP5; SDRP1; Tiul1; Wwp1", "protein_names_uniprotkb": "NEDD4-like E3 ubiquitin-protein ligase WWP1; 2.3.2.26; HECT-type E3 ubiquitin transferase WWP1; WW domain-containing protein 1", "protein_names_refseq": "HECT-type E3 ubiquitin transferase WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform 2; NEDD4-like E3 ubiquitin-protein ligase WWP1; WW domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:107568); (R-MMU-1253288); (R-MMU-2672351); (R-MMU-983168)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "11375995;15003522;15735697;16728642;18724389;18806757;19144319;19561640;30084848;34428180;34907909;35820727;37032433;38561589", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF (By similarity). Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Activates the Hippo signaling pathway in response to cell contact inhibition and recruitment to the Crumbs complex at the cell membrane (By similarity). Monoubiquitinates AMOTL2 which facilitates its interaction with and activation of LATS2 (By similarity). LATS2 then phosphorylates YAP1, excluding it from the nucleus and therefore ultimately represses YAP1-driven transcription of target genes (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Systemic depletion of WWP1 improves insulin sensitivity and lowers triglyceride content in the liver of obese mice., [RefSeq, PubMed]; The R436Q missense mutation in WWP1 disrupts autoinhibition of its E3 ubiquitin ligase activity, leading to self-degradation and loss of function., [RefSeq, PubMed]; WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIV9;Q8VDP8", "ec_number_list": "2.3.2.26;2.3.2.31;2.3.2.27;2.3.2.-;3.6.4.-;3.4.19.12;3.4.25.1;2.3.2.24;2.3.2.23;2.3.2.34;2.3.2.32;2.7.11.1;2.7.10.1;2.3.2.36;2.3.2.25;6.2.1.-", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0030324 lung development;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0030217 T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BZZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8C8N3-1", "uniprot_id": "VWC2_MOUSE", "mass": 35383.0, "length": 324, "protein_name": "Brorin", "gene_name": "Vwc2", "organism": "Mouse", "refseq_name": "brorin precursor", "refseq_ac": "NP_796007", "gene_names_uniprotkb": "Vwc2", "gene_names_refseq": "A930041G11Rik; G11; PSST739; UNQ739; Vwc2; cradin", "protein_names_uniprotkb": "Brorin; Brain-specific chordin-like protein; CR (chordin-like cysteine-rich) domain-containing adhesive protein; Cradin; von Willebrand factor C domain-containing protein 2", "protein_names_refseq": "CR (chordin-like cysteine-rich) domain-containing adhesive protein; brain-specific chordin-like protein; brorin precursor; brorin; von Willebrand factor C domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:319922)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17400546;18757743;22632720;30074079", "class_list": "", "function": "BMP antagonist which may play a role in neural development. Promotes cell adhesion., [UniProtKB, PubMed, PubMed]; Our data indicate that VWC2, a bone matrix-associated secretory protein, enhances cranial bone formation through inhibiting Activin signaling and activin-induced cell functions via direct binding to activin A, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RQ98;Q5SSH5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0032281 AMPA glutamate receptor complex", "go_biological_process": "GO:0045666 positive regulation of neuron differentiation;GO:0010811 positive regulation of cell-substrate adhesion;GO:0030514 negative regulation of BMP signaling pathway;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C8N3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CHS8-1", "uniprot_id": "VP37A_MOUSE", "mass": 44419.0, "length": 397, "protein_name": "Vacuolar protein sorting-associated protein 37A", "gene_name": "Vps37a", "organism": "Mouse", "refseq_name": "vacuolar protein sorting-associated protein 37A", "refseq_ac": "NP_291038", "gene_names_uniprotkb": "Vps37a", "gene_names_refseq": "2210018P21Rik; 4930592A21Rik; D8Ertd531e; Vps37a", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 37A; ESCRT-I complex subunit VPS37A; Vps37A", "protein_names_refseq": "ESCRT-I complex subunit VPS37A; vacuolar protein sorting-associated protein 37A", "tax_id": 10090, "disease": "hereditary spastic paraplegia 53 (Disease Ontology:DOID:0110805)", "pathway": " (mmu:52348); (R-MMU-917729)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;31219806;34428180;36852467;40021952;40885482", "class_list": "", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGD1;Q3TBI5;Q3TC15;Q3TC26", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0006623 protein targeting to vacuole;GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8CHS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CI71-1", "uniprot_id": "VPS50_MOUSE", "mass": 111174.0, "length": 964, "protein_name": "Syndetin", "gene_name": "Vps50", "organism": "Mouse", "refseq_name": "syndetin isoform 2", "refseq_ac": "NP_001161222", "gene_names_uniprotkb": "Vps50; Ccdc132; Kiaa1861", "gene_names_refseq": "1700034M03Rik; 8430415E05Rik; BLM; Ccdc132; Vps50; mKIAA1861", "protein_names_uniprotkb": "Syndetin; Bcl2-like protein blm; Coiled-coil domain-containing protein 132; EARP/GARPII complex subunit VPS50", "protein_names_refseq": "EARP/GARPII complex subunit VPS50; bcl2-like protein blm; coiled-coil domain containing 132; coiled-coil domain-containing protein 132; syndetin isoform 2; syndetin", "tax_id": 10090, "disease": "", "pathway": " (mmu:73288)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21183079;22872234;25428506;26948874;29187734;31219806;34428180;38926759", "class_list": "", "function": "Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN)., [UniProtKB, UniProtKB]; An evolutionarily conserved C. elegans protein, VPS-50, that is required for animals to assume the well-fed behavioral state. Both VPS-50 and its murine homolog mVPS50 are expressed in neurons, are associated with synaptic and dense-core vesicles, and control vesicle acidification and hence synaptic function, likely through regulation of the assembly of the V-ATPase complex., [RefSeq, PubMed]; Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPG9;Q7TSR5;Q80XR1;Q8C6D0;Q8C9I6;Q99LN1", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:1990745 EARP complex;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome", "go_biological_process": "GO:0015031 protein transport;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CI71-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8R0S6-1", "uniprot_id": "WFKN1_MOUSE", "mass": 59794.0, "length": 552, "protein_name": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1", "gene_name": "Wfikkn1", "organism": "Mouse", "refseq_name": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor", "refseq_ac": "NP_001093924", "gene_names_uniprotkb": "Wfikkn1; Gasp2", "gene_names_refseq": "Gasp2; Wfikkn1; Wfikkn", "protein_names_uniprotkb": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1; GASP-2; Growth and differentiation factor-associated serum protein 2; mGASP-2", "protein_names_refseq": "GASP-2; WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor; WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1; growth and differentiation factor-associated serum protein 2; mGASP-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:215001)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12595574;21750661;24019467", "class_list": "", "function": "GASP-1 and GASP-2 are important modulators of GDF-11 and MSTN activity in vivo., [RefSeq, PubMed]; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0048019 receptor antagonist activity;GO:0050431 transforming growth factor beta binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0001501 skeletal system development;GO:0060021 roof of mouth development;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R0S6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCS3-1", "uniprot_id": "XYLK_MOUSE", "mass": 46581.0, "length": 409, "protein_name": "Glycosaminoglycan xylosylkinase", "gene_name": "Fam20b", "organism": "Mouse", "refseq_name": "glycosaminoglycan xylosylkinase isoform a", "refseq_ac": "NP_663388", "gene_names_uniprotkb": "Fam20b", "gene_names_refseq": "C530043G21Rik; Fam20b; mKIAA0475", "protein_names_uniprotkb": "Glycosaminoglycan xylosylkinase; 2.7.1.-; Xylose kinase", "protein_names_refseq": "family with sequence similarity 20, member B; glycosaminoglycan xylosylkinase isoform a; glycosaminoglycan xylosylkinase; xylose kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:215015); (R-MMU-1971475)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21549343;22732358;22900076;25428506;27802388;30084848;31219806;32664967;34428180;37298583", "class_list": "glycogene", "function": "Deficiency of Fam20b-Catalyzed Glycosaminoglycan Chain Synthesis in Neural Crest Leads to Cleft Palate. Publication Status: Online-Only, [RefSeq, PubMed]; FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V201;Q6ZQA3;Q8BWX2", "ec_number_list": "2.7.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016301 kinase activity;GO:0016773 phosphotransferase activity, alcohol group as acceptor", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VCS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91WL8-1", "uniprot_id": "WWOX_MOUSE", "mass": 46512.0, "length": 414, "protein_name": "WW domain-containing oxidoreductase", "gene_name": "Wwox", "organism": "Mouse", "refseq_name": "WW domain-containing oxidoreductase isoform 1", "refseq_ac": "NP_062519", "gene_names_uniprotkb": "Wwox; Wox1", "gene_names_refseq": "5330426P09Rik; 9030416C10Rik; WOX1; Wwox", "protein_names_uniprotkb": "WW domain-containing oxidoreductase; 1.1.1.-", "protein_names_refseq": "WW domain-containing oxidoreductase isoform 1; WW-domain oxidoreductase", "tax_id": 10090, "disease": "autosomal recessive spinocerebellar ataxia 12 (Disease Ontology:DOID:0080060); developmental and epileptic encephalopathy 28 (Disease Ontology:DOID:0080452); Leber congenital amaurosis (Disease Ontology:DOID:14791); cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); epilepsy (Disease Ontology:DOID:1826); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (mmu:80707); (R-MMU-1251985); (R-MMU-8866904); (R-MMU-8866907)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "11058590;11979549;12514174;15026124;15126504;15345747;15664696;16219768;17360458;18487609;19366691;21183079;25428506;31315632;31752354;32764489;35883580;38182577;38203337;38563965", "class_list": "", "function": "Endothelial knockdown of the tumor suppressor, WWOX, increases inflammation in ventilator-induced lung injury., [RefSeq, PubMed]; Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylation of JNK1 and WOX1 is necessary for their physical interaction and functional antagonism, [RefSeq, PubMed]; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity). May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development., [UniProtKB, PubMed, PubMed]; The intron/exon boundaries of Wox1 have been identified; the genomic organization has been found to be almost identical to that of human WWOX., [RefSeq, PubMed]; WWOX promotes osteosarcoma development via upregulation of Myc. Erratum:[Cell Death Dis. 2024 Feb 14;15(2):141. doi: 10.1038/s41419-024-06518-8. PMID: 38355659] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8J6;Q920Y2;Q9D2B3;Q9D339;Q9JLF5", "ec_number_list": "2.7.10.1;1.1.1.-", "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway;GO:0016055 Wnt signaling pathway;GO:0071560 cellular response to transforming growth factor beta stimulus;GO:0097191 extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q91WL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q924C1-1", "uniprot_id": "XPO5_MOUSE", "mass": 136973.0, "length": 1204, "protein_name": "Exportin-5", "gene_name": "Xpo5", "organism": "Mouse", "refseq_name": "exportin-5", "refseq_ac": "NP_082474", "gene_names_uniprotkb": "Xpo5; Kiaa1291; Ranbp21", "gene_names_refseq": "2410004H11Rik; 2700038C24Rik; Exp5; RanBp21; Xpo5; mKIAA1291", "protein_names_uniprotkb": "Exportin-5; Exp5; Ran-binding protein 21", "protein_names_refseq": "exportin-5; ran-binding protein 21", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409); primary ovarian insufficiency (Disease Ontology:DOID:5426); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:72322)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12426392;20852728;25428506;29414394;30084848;30779550;31219806;39627609", "class_list": "", "function": "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm., [RefSeq, PubMed]; Mediates the nuclear export of micro-RNA precursors, which form short hairpins. Also mediates the nuclear export of synthetic short hairpin RNAs used for RNA interference. In some circumstances can also mediate the nuclear export of deacylated and aminoacylated tRNAs. Specifically recognizes dsRNAs that lack a 5'-overhang in a sequence-independent manner, have only a short 3'-overhang, and that have a double-stranded length of at least 15 base-pairs. Binding is dependent on Ran-GTP (By similarity)., [UniProtKB, UniProtKB]; Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi) (By similarity). Mediates nuclear export of ADAR/ADAR1 in a RanGTP-dependent manner (By similarity)., [UniProtKB, UniProtKB]; MiRNA biogenesis components Drosha, Dgcr8, Exportin-5 and Dicer1 are expressed in the mouse uterus and that Exportin-5 and Dicer1 appear to be the major steroid regulated components in the miRNA biogenesis pathway, [RefSeq, PubMed]; Productive reoviral infection is strongly correlated with elevated importin-beta and exportin-5 levels which may serve as biomarkers of the disease in clinical specimens, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RRJ5;Q7TMP2;Q80TF9;Q9CRI9;Q9CT48", "ec_number_list": "", "go_molecular_function": "GO:1905172 RISC complex binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000049 tRNA binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016442 RISC complex", "go_biological_process": "GO:0006611 protein export from nucleus;GO:0006405 RNA export from nucleus;GO:0035281 pre-miRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q924C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CR51-1", "uniprot_id": "VATG1_MOUSE", "mass": 13724.0, "length": 118, "protein_name": "V-type proton ATPase subunit G 1", "gene_name": "Atp6v1g1", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit G 1", "refseq_ac": "NP_077135", "gene_names_uniprotkb": "Atp6v1g1; Atp6g1", "gene_names_refseq": "1810024D14Rik; ATP6J; Atp6g1; Atp6v1g1; VAG1; Vma10", "protein_names_uniprotkb": "V-type proton ATPase subunit G 1; V-ATPase 13 kDa subunit 1; V-ATPase subunit G 1; Vacuolar proton pump subunit G 1", "protein_names_refseq": "ATPase, H+ transporting, V1 subunit G; ATPase, H+ transporting, lysosomal (vacuolar proton pump); ATPase, H+ transporting, lysosomal 13kD, V1 subunit G; V-ATPase 13 kDa subunit 1; V-ATPase subunit G 1; V-type proton ATPase subunit G 1; lysosomal 13kDa; vacuolar proton pump subunit G 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66290); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "12133826;12527205;28135057;28528544;29993276;38702933", "class_list": "", "function": "Plasma exosomes impair microglial degradation of alpha-synuclein through V-ATPase subunit V1G1., [RefSeq, PubMed]; Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment. The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation., [UniProtKB, UniProtKB]; V-ATPase G1 and G2 isoforms are expressed in mouse embryo neurons and are involved in synaptic vesicle acidification, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033180 proton-transporting V-type ATPase, V1 domain;GO:0033176 proton-transporting V-type ATPase complex;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0036295 cellular response to increased oxygen levels;GO:0097401 synaptic vesicle lumen acidification;GO:0038020 insulin receptor recycling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CR51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9CXE6-1", "uniprot_id": "XRCC3_MOUSE", "mass": 38446.0, "length": 349, "protein_name": "DNA repair protein XRCC3", "gene_name": "Xrcc3", "organism": "Mouse", "refseq_name": "DNA repair protein XRCC3", "refseq_ac": "NP_083151", "gene_names_uniprotkb": "Xrcc3", "gene_names_refseq": "Xrcc3", "protein_names_uniprotkb": "DNA repair protein XRCC3; X-ray repair cross-complementing protein 3", "protein_names_refseq": "DNA repair protein XRCC3; X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair cross-complementing protein 3", "tax_id": 10090, "disease": "brain glioma (Disease Ontology:DOID:0060108); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); high grade glioma (Disease Ontology:DOID:3070); coronary artery disease (Disease Ontology:DOID:3393); meningioma (Disease Ontology:DOID:3565); central nervous system cancer (Disease Ontology:DOID:3620); myocardial infarction (Disease Ontology:DOID:5844); familial melanoma (Disease Ontology:DOID:6846); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:74335); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "17114795;34601382", "class_list": "", "function": "Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C (By similarity)., [UniProtKB]; The RAD51C-XRCC3-associated Holliday junction resolvase complex associates with crossovers and may play an essential role in the resolution of recombination intermediates prior to chromosome segregation, [RefSeq, PubMed]; This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. Allelic variants in the human gene are associated with susceptibility to breast cancer and cutaneous malignant melanoma. [provided by RefSeq, Sep 2015]., [RefSeq]; XRCC3 loss leads to midgestational embryonic lethality in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0000400 four-way junction DNA binding;GO:0008821 crossover junction DNA endonuclease activity;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0033065 Rad51C-XRCC3 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0006281 DNA repair;GO:0000724 double-strand break repair via homologous recombination;GO:0036297 interstrand cross-link repair;GO:0090656 t-circle formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CXE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D0R9-1", "uniprot_id": "WDR89_MOUSE", "mass": 42470.0, "length": 386, "protein_name": "WD repeat-containing protein 89", "gene_name": "Wdr89", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 89", "refseq_ac": "NP_082479", "gene_names_uniprotkb": "Wdr89", "gene_names_refseq": "2600001A11Rik; Wdr89", "protein_names_uniprotkb": "WD repeat-containing protein 89", "protein_names_refseq": "WD repeat-containing protein 89", "tax_id": 10090, "disease": "", "pathway": " (mmu:72338)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0021591 ventricular system development;GO:0022038 corpus callosum development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D0R9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D994-1", "uniprot_id": "WDR38_MOUSE", "mass": 33052.0, "length": 303, "protein_name": "WD repeat-containing protein 38", "gene_name": "Wdr38", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 38", "refseq_ac": "NP_083963", "gene_names_uniprotkb": "Wdr38", "gene_names_refseq": "1700123D08Rik; Wdr38", "protein_names_uniprotkb": "WD repeat-containing protein 38", "protein_names_refseq": "WD repeat-containing protein 38; novel WD domain, G-beta repeat domain containing protein (1700123D08Rik)", "tax_id": 10090, "disease": "", "pathway": " (mmu:76646)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "37635409", "class_list": "", "function": "WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D994-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DB94-1", "uniprot_id": "WDR53_MOUSE", "mass": 38642.0, "length": 358, "protein_name": "WD repeat-containing protein 53", "gene_name": "Wdr53", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 53", "refseq_ac": "NP_001172091", "gene_names_uniprotkb": "Wdr53", "gene_names_refseq": "1500002B03Rik; Wdr53", "protein_names_uniprotkb": "WD repeat-containing protein 53", "protein_names_refseq": "WD repeat-containing protein 53", "tax_id": 10090, "disease": "", "pathway": " (mmu:68980)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DB94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9EPK2-1", "uniprot_id": "XRP2_MOUSE", "mass": 39377.0, "length": 347, "protein_name": "Protein XRP2", "gene_name": "Rp2", "organism": "Mouse", "refseq_name": "protein XRP2 isoform a", "refseq_ac": "NP_001277572", "gene_names_uniprotkb": "Rp2; Rp2h", "gene_names_refseq": "Rp2h; Rp2", "protein_names_uniprotkb": "Protein XRP2", "protein_names_refseq": "protein XRP2 isoform a; protein XRP2", "tax_id": 10090, "disease": "retinitis pigmentosa 2 (Disease Ontology:DOID:0110415); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:19889); (R-MMU-5624138)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11371510;12417528;20106869;23745007;26358772;26383048;26495903;26740625;26936825;31219806;34428180", "class_list": "", "function": "Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as a guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins., [UniProtKB]; Our studies suggest that RP2 contributes to the maintenance of photoreceptor function and that cone opsin mislocalization represents an early step in XLRP caused by RP2 mutations. Publication Status: Online-Only, [RefSeq, PubMed]; RP2 has a role in cone photoreceptor sensory cilium elongation in mice, [RefSeq, PubMed]; This study identifies ARL3 as a key player in prenylated protein trafficking in rod photoreceptor cells and establishes the potential role for ARL3 dysregulation in the pathogenesis of RP2-related forms of X-linked retinitis pigmentosa, [RefSeq, PubMed]; We first performed detailed characterization of the Rp2-knockout (Rp2-KO) mice and observed early-onset cone dysfunction, [RefSeq, PubMed]; We propose that RP2 regulation of Arl3 is important for maintaining Golgi cohesion, facilitating the transport and docking of vesicles and thereby carrying proteins to the base of the photoreceptor connecting cilium for transport to the outer segment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLN8;Q8BVQ8;Q8BZP9", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005096 GTPase activator activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0006892 post-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9EPK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ESH5-1", "uniprot_id": "WFDC1_MOUSE", "mass": 23079.0, "length": 211, "protein_name": "WAP four-disulfide core domain protein 1", "gene_name": "Wfdc1", "organism": "Mouse", "refseq_name": "WAP four-disulfide core domain protein 1 precursor", "refseq_ac": "NP_075884", "gene_names_uniprotkb": "Wfdc1; Ps20", "gene_names_refseq": "2310058A03Rik; Wfdc1; ps20", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 1; Prostate stromal protein ps20; ps20 growth inhibitor", "protein_names_refseq": "WAP four-disulfide core domain protein 1 precursor; WAP four-disulfide core domain protein 1; prostate stromal protein ps20; ps20 growth inhibitor", "tax_id": 10090, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (mmu:67866)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10967136;14522910;25219356", "class_list": "", "function": "Has growth inhibitory activity., [UniProtKB]; Ps20 may be a TGF-beta1-induced regulator of angiogenesis that functions by either promoting endothelial cell migration or by contributing to pericyte stabilization of newly formed vascular structures., [RefSeq, PubMed]; WFDC1/ps20 modulates core host response mechanisms, in part, via regulation of osteopontin and MMP-9 activity. Release from WFDC1 regulation is likely a key component of inflammatory and repair response mechanisms., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R110", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050680 negative regulation of epithelial cell proliferation;GO:0050728 negative regulation of inflammatory response;GO:0001558 regulation of cell growth;GO:0061045 negative regulation of wound healing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ESH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHA8-1", "uniprot_id": "VWA7_MOUSE", "mass": 95984.0, "length": 891, "protein_name": "von Willebrand factor A domain-containing protein 7", "gene_name": "Vwa7", "organism": "Mouse", "refseq_name": "von Willebrand factor A domain-containing protein 7 isoform 1 precursor", "refseq_ac": "NP_613048", "gene_names_uniprotkb": "Vwa7; D17h6s56e-3; G7c", "gene_names_refseq": "C6orf27; D17H6S56E-3; G7c; NG37; Vwa7", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 7; Protein G7c", "protein_names_refseq": "corresponds to Mus musculus G7c mRNA sequence presented in GenBank Accession Number AF134319; protein G7c; similar to Homo sapiens G7c protein encoded by GenBank Accession Number AJ245418; von Willebrand factor A domain-containing protein 7 isoform 1 precursor; von Willebrand factor A domain-containing protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:27762)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10803853;11797099;14656967", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1Q8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JHA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHY3-1", "uniprot_id": "WFD12_MOUSE", "mass": 9559.0, "length": 85, "protein_name": "WAP four-disulfide core domain protein 12", "gene_name": "Wfdc12", "organism": "Mouse", "refseq_name": "WAP four-disulfide core domain protein 12 precursor", "refseq_ac": "NP_619625", "gene_names_uniprotkb": "Wfdc12; Swam2", "gene_names_refseq": "Swam2; WAP2; Wfdc12", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 12; Elafin-like protein II; Single WAP motif protein 2; Whey acidic protein 2", "protein_names_refseq": "WAP four-disulfide core domain protein 12 precursor; WAP four-disulfide core domain protein 12; elafin-like protein II; single WAP motif protein 2; whey acidic protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:192200)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12574366;36148224", "class_list": "", "function": "A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the pathogenesis and development of psoriasis disease. Publication Status: Online-Only, [RefSeq, PubMed]; Antibacterial protein which inhibits the growth of E.coli and S.aureus. Putative acid-stable proteinase inhibitor., [UniProtKB, PubMed, UniProtKB]; The antibacterial protein SWAM2 is constitutively expressed in tongue and inhibits the growth of both Escherichia coli and Staphylococcus aureus at an IC90 of 10 microM., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JHY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JHY4-1", "uniprot_id": "WF15B_MOUSE", "mass": 9237.0, "length": 80, "protein_name": "WAP four-disulfide core domain protein 15B", "gene_name": "Wfdc15b", "organism": "Mouse", "refseq_name": "WAP four-disulfide core domain protein 15B precursor", "refseq_ac": "NP_001039019", "gene_names_uniprotkb": "Wfdc15b; Swam1; Wfdc15", "gene_names_refseq": "9230106L14Rik; SWAM1; Wfdc15b; Wfdc15", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 15B; Elafin-like protein I; Single WAP motif protein 1", "protein_names_refseq": "WAP four-disulfide core domain 15; WAP four-disulfide core domain protein 15B precursor; WAP four-disulfide core domain protein 15B; elafin-like protein I; single WAP motif protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:192201)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12574366;15950183", "class_list": "", "function": "Antibacterial protein which inhibits the growth of E.coli and S.aureus., [UniProtKB, PubMed]; The antibacterial protein SWAM1 is constitutively expressed in kidney and epididymis and inhibits the growth of both Escherichia coli and Staphylococcus aureus at an IC90 of 10 microM., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A5M6;Q8BVC0", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JHY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WTP9-1", "uniprot_id": "VAX2_MOUSE", "mass": 31701.0, "length": 292, "protein_name": "Ventral anterior homeobox 2", "gene_name": "Vax2", "organism": "Mouse", "refseq_name": "ventral anterior homeobox 2", "refseq_ac": "NP_036042", "gene_names_uniprotkb": "Vax2; Vex", "gene_names_refseq": "Dres93; Vax2", "protein_names_uniprotkb": "Ventral anterior homeobox 2; Ventral retina homeodomain protein", "protein_names_refseq": "ventral anterior homeobox 2; ventral anterior homeobox containing gene 2; ventral retina homeodomain protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:24113)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10421837;10485894;10595508;11830578;21856776", "class_list": "", "function": "Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle. May be a regulator of axial polarization in the retina., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031490 chromatin DNA binding;GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007409 axonogenesis;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WTP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9WUD6-1", "uniprot_id": "WNT8B_MOUSE", "mass": 38576.0, "length": 350, "protein_name": "Protein Wnt-8b", "gene_name": "Wnt8b", "organism": "Mouse", "refseq_name": "protein Wnt-8b precursor", "refseq_ac": "NP_035850", "gene_names_uniprotkb": "Wnt8b", "gene_names_refseq": "Wnt8b", "protein_names_uniprotkb": "Protein Wnt-8b", "protein_names_refseq": "protein Wnt-8b precursor; protein Wnt-8b; wingless related MMTV integration site 8b", "tax_id": 10090, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487)", "pathway": " (mmu:22423); (R-MMU-3238698); (R-MMU-4641262)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10441746", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007165 signal transduction;GO:0007267 cell-cell signaling;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WUD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Z0H1-1", "uniprot_id": "WDR46_MOUSE", "mass": 69048.0, "length": 622, "protein_name": "WD repeat-containing protein 46", "gene_name": "Wdr46", "organism": "Mouse", "refseq_name": "WD repeat-containing protein 46", "refseq_ac": "NP_065628", "gene_names_uniprotkb": "Wdr46; Bing4", "gene_names_refseq": "2310007I04Rik; Bing4; Wdr46", "protein_names_uniprotkb": "WD repeat-containing protein 46; WD repeat-containing protein BING4", "protein_names_refseq": "WD repeat-containing protein 46; WD repeat-containing protein BING4; putative WD repeat domain 46", "tax_id": 10090, "disease": "", "pathway": " (mmu:57315); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;25428506;30084848;34428180;34887587;35820727", "class_list": "", "function": "Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z0H1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99ML0-1", "uniprot_id": "ZMY10_MOUSE", "mass": 50646.0, "length": 440, "protein_name": "Zinc finger MYND domain-containing protein 10", "gene_name": "Zmynd10", "organism": "Mouse", "refseq_name": "zinc finger MYND domain-containing protein 10 isoform 1", "refseq_ac": "NP_444483", "gene_names_uniprotkb": "Zmynd10; Blu", "gene_names_refseq": "Blu; Zmynd10", "protein_names_uniprotkb": "Zinc finger MYND domain-containing protein 10; Protein BLu", "protein_names_refseq": "protein BLu; zinc finger MYND domain-containing protein 10 isoform 1; zinc finger MYND domain-containing protein 10", "tax_id": 10090, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); primary ciliary dyskinesia 22 (Disease Ontology:DOID:0110597); sensorineural hearing loss (Disease Ontology:DOID:10003); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:114602)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23891471;29601588;29916806", "class_list": "", "function": "Plays a role in axonemal structure organization and motility (PubMed:29601588). Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (PubMed:29601588). May act by indirectly regulating transcription of dynein proteins (By similarity)., [UniProtKB, PubMed]; Results demonstrated that ZMYND10 regulated the early stage of DA cytoplasmic pre-assembly by stabilizing DNAI1 Publication Status: Online-Only, [RefSeq, PubMed]; ZMYND10 is a novel co-chaperone that confers specificity for the FKBP8-HSP90 chaperone complex towards axonemal dynein clients required for cilia motility. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1P0;Q80W73", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016324 apical plasma membrane;GO:0034451 centriolar satellite;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0006457 protein folding;GO:0044458 motile cilium assembly;GO:0061512 protein localization to cilium;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99ML0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q811F1-1", "uniprot_id": "ZBT41_MOUSE", "mass": 104683.0, "length": 908, "protein_name": "Zinc finger and BTB domain-containing protein 41", "gene_name": "Zbtb41", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 41", "refseq_ac": "NP_766231", "gene_names_uniprotkb": "Zbtb41", "gene_names_refseq": "8430415N23Rik; 9430031N01; 9830132G07Rik; Zbtb41", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 41", "protein_names_refseq": "zinc finger and BTB domain containing 41 homolog; zinc finger and BTB domain-containing protein 41", "tax_id": 10090, "disease": "", "pathway": " (mmu:226470)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A706;Q8BI96;Q8BV67;Q8BYV8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q811F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1L1SU13-1", "uniprot_id": "A0A1L1SU13_MOUSE", "mass": 35117.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or4c118", "organism": "Mouse", "refseq_name": "olfactory receptor 1223", "refseq_ac": "NP_667103", "gene_names_uniprotkb": "Or4c118; Olfr1223", "gene_names_refseq": "MOR233-10; Olfr1223; Or4c118", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "GA_x6K02T2Q125-50623664-50622729; olfactory receptor 1223; olfactory receptor MOR233-10", "tax_id": 10090, "disease": "", "pathway": " (mmu:258894)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1L1SU13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q810J8-1", "uniprot_id": "ZFYV1_MOUSE", "mass": 86940.0, "length": 777, "protein_name": "Zinc finger FYVE domain-containing protein 1", "gene_name": "Zfyve1", "organism": "Mouse", "refseq_name": "zinc finger FYVE domain-containing protein 1 isoform 1", "refseq_ac": "NP_898977", "gene_names_uniprotkb": "Zfyve1", "gene_names_refseq": "DFCP1; G630053K23; TAFF1; ZNFN2A1; Zfyve1; mKIAA1589", "protein_names_uniprotkb": "Zinc finger FYVE domain-containing protein 1", "protein_names_refseq": "zinc finger FYVE domain-containing protein 1 isoform 1; zinc finger FYVE domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:217695)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21750661;22645316;25876663;30970241;31293035;31388100;31616917;32251420;35820727;40885482", "class_list": "", "function": "Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:30970241, PubMed:31293035). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contact sites by forming a complex with RAB18 and ZW10 (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding., [RefSeq, PubMed]; ZFYVE1 acts as a specific negative regulator of MDA5-mediated innate immune responses by inhibiting its ligand binding and oligomerization. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TC20", "ec_number_list": "", "go_molecular_function": "GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008270 zinc ion binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0005545 1-phosphatidylinositol binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0044829 host-mediated activation of viral genome replication;GO:0016236 macroautophagy;GO:0009267 cellular response to starvation;GO:0140042 lipid droplet formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q810J8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U2E2-1", "uniprot_id": "ZMYM5_MOUSE", "mass": 70071.0, "length": 627, "protein_name": "Zinc finger MYM-type protein 5", "gene_name": "Zmym5", "organism": "Mouse", "refseq_name": "zinc finger MYM-type protein 5", "refseq_ac": "NP_001240681", "gene_names_uniprotkb": "Zmym5", "gene_names_refseq": "9830124H08Rik; Zmym5", "protein_names_uniprotkb": "Zinc finger MYM-type protein 5", "protein_names_refseq": "zinc finger MYM-type protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:219105)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;34428180;36210013", "class_list": "", "function": "Functions as a transcriptional regulator., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1W3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3U2E2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2A6P4-1", "uniprot_id": "A2A6P4_MOUSE", "mass": 19618.0, "length": 185, "protein_name": "VCP nuclear cofactor family member 1", "gene_name": "Vcf1", "organism": "Mouse", "refseq_name": "protein VCF1 isoform 2", "refseq_ac": "NP_613064", "gene_names_uniprotkb": "Vcf1; D11Wsu99e", "gene_names_refseq": "D11Wsu99e; Fam104a; Vcf1", "protein_names_uniprotkb": "VCP nuclear cofactor family member 1", "protein_names_refseq": "family with sequence similarity 104, member A; protein VCF1 isoform 2", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "21750661;24129315", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2A6P4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O35149-1", "uniprot_id": "ZNT4_MOUSE", "mass": 47800.0, "length": 430, "protein_name": "Probable proton-coupled zinc antiporter SLC30A4", "gene_name": "Slc30a4", "organism": "Mouse", "refseq_name": "probable proton-coupled zinc antiporter SLC30A4 isoform b", "refseq_ac": "NP_001277922", "gene_names_uniprotkb": "Slc30a4; Lm; Znt4", "gene_names_refseq": "Slc30a4; Znt4; lm; znT-4", "protein_names_uniprotkb": "Probable proton-coupled zinc antiporter SLC30A4; Lethal milk protein; Solute carrier family 30 member 4; Zinc transporter 4; ZnT-4", "protein_names_refseq": "lethal milk protein; probable proton-coupled zinc antiporter SLC30A4 isoform b; probable proton-coupled zinc antiporter SLC30A4; solute carrier family 30 (zinc transporter), member 4; solute carrier family 30 member 4; zinc transporter 4", "tax_id": 10090, "disease": "prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (mmu:22785)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17101726;21183079;21750661;26538236;32501158;9354792", "class_list": "", "function": "Loss of ZnT4 has profound consequences on mammary epithelial cell secretion and may promote tissue remodeling in the mammary gland during early lactation., [RefSeq, PubMed]; MicroRNA-30a regulates acute cerebral ischemia-induced blood-brain barrier damage through ZnT4/zinc pathway., [RefSeq, PubMed]; Probable proton-coupled zinc ion antiporter mediating zinc import from cytoplasm potentially into the endocytic compartment (PubMed:9354792). Controls zinc deposition in milk (PubMed:9354792)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35154;Q3UYZ9", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046872 metal ion binding;GO:0015297 antiporter activity;GO:0008324 monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0005770 late endosome", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0010043 response to zinc ion;GO:0009636 response to toxic substance;GO:0140882 zinc export across plasma membrane;GO:0140916 zinc ion import into lysosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35149-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2AU83-1", "uniprot_id": "A2AU83_MOUSE", "mass": 83428.0, "length": 715, "protein_name": "Zinc finger protein 1005", "gene_name": "Zfp1005", "organism": "Mouse", "refseq_name": "zinc finger protein family member", "refseq_ac": "NP_001135882", "gene_names_uniprotkb": "Zfp1005; Gm14124", "gene_names_refseq": "EG640962; Gm10749; Gm14124; Zfp1005", "protein_names_uniprotkb": "Zinc finger protein 1005", "protein_names_refseq": "zinc finger protein family member", "tax_id": 10090, "disease": "", "pathway": " (mmu:100216455)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0003684 damaged DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AU83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B1APN4-1", "uniprot_id": "B1APN4_MOUSE", "mass": 25051.0, "length": 224, "protein_name": "Reproductive homeobox 1", "gene_name": "Rhox1", "organism": "Mouse", "refseq_name": "reproductive homeobox 1", "refseq_ac": "NP_001020255", "gene_names_uniprotkb": "Rhox1", "gene_names_refseq": "Rhox1", "protein_names_uniprotkb": "Reproductive homeobox 1", "protein_names_refseq": "reproductive homeobox 1; reproductive homeobox on X chromosome 1; reproductive homeobox on chromosome X, 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:385343)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1APN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5SS00-1", "uniprot_id": "ZDBF2_MOUSE", "mass": 273748.0, "length": 2493, "protein_name": "DBF4-type zinc finger-containing protein 2 homolog", "gene_name": "Zdbf2", "organism": "Mouse", "refseq_name": "DBF4-type zinc finger-containing protein 2 homolog isoform 1", "refseq_ac": "NP_001254801", "gene_names_uniprotkb": "Zdbf2", "gene_names_refseq": "4930431J08Rik; 9330107J05Rik; Zdbf2", "protein_names_uniprotkb": "DBF4-type zinc finger-containing protein 2 homolog", "protein_names_refseq": "DBF4-type zinc finger-containing protein 2 homolog isoform 1; DBF4-type zinc finger-containing protein 2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:73884)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19200453;20385583;21750661;22449967;24589776;35049495;36852467", "class_list": "", "function": "A maternal germline differentially methylated region (DMR) at the mouse Gpr1/Zdbf2 (DBF-type zinc finger-containing protein 2) locus, which controls the paternal-specific expression of long isoforms of Zdbf2 (Liz) in the early embryo, [RefSeq, PubMed]; Identification of differentially methylated regions within the Gpr1-Zdbf2 imprinted domain., [RefSeq, PubMed]; Results identified a novel, paternally expressed, long intergenic non-coding Zdbf2 variant (Zdbf2linc) transcribed from maternally methylated Gpr1 during early embryogenesis in the mouse., [RefSeq, PubMed]; The imprinted Zdbf2 gene finely tunes control of feeding and growth in neonates. Publication Status: Online-Only, [RefSeq, PubMed]; Zdbf2 was paternally expressed in various embryonic and adult tissues, except for the placenta and adult testis, which showed biallelic expression of the gene., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0Y4;Q9CUN4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "GO:0043045 epigenetic programming of gene expression;GO:0071514 genomic imprinting", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q5SS00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D9X6-1", "uniprot_id": "ZSWM2_MOUSE", "mass": 71793.0, "length": 631, "protein_name": "E3 ubiquitin-protein ligase Zswim2", "gene_name": "Zswim2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase Zswim2 isoform 1", "refseq_ac": "NP_082240", "gene_names_uniprotkb": "Zswim2", "gene_names_refseq": "1700025P14Rik; 4933437F18Rik; MEX; Zswim2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Zswim2; 2.3.2.27; MEKK1-related protein X; MEX; RING-type E3 ubiquitin transferase Zswim2; ZZ-type zinc finger-containing protein 2; Zinc finger SWIM domain-containing protein 2", "protein_names_refseq": "E3 ubiquitin-protein ligase Zswim2 isoform 1; E3 ubiquitin-protein ligase Zswim2; MEKK1-related protein X; RING-type E3 ubiquitin transferase Zswim2; ZZ-type zinc finger-containing protein 2; zinc finger SWIM domain-containing protein 2; zinc finger, SWIM domain containing 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71861)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16522193;21750661;34428180;35831855", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes., [UniProtKB, PubMed]; MEX(identical to Zswim2) has homology to MEKK1 & is expressed uniquely in testis. MEX has 4 putative zinc-binding domains including an N-terminal SWIM (SWI2/SNF2 & MuDR) domain of unknown function & 2 RING fingers separated by ZZ zinc finger domain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "", "go_biological_process": "GO:0006915 apoptotic process;GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D9X6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B2RUI1-1", "uniprot_id": "ZN551_MOUSE", "mass": 79722.0, "length": 696, "protein_name": "Zinc finger protein 551", "gene_name": "Zfp551; Znf551", "organism": "Mouse", "refseq_name": "zinc finger protein 551", "refseq_ac": "NP_001028992", "gene_names_uniprotkb": "Zfp551; Znf551; Zfp551", "gene_names_refseq": "9630004E07Rik; Zfp551; Znf551", "protein_names_uniprotkb": "Zinc finger protein 551", "protein_names_refseq": "zinc finger protein 551; zinc fingr protein 551", "tax_id": 10090, "disease": "", "pathway": " (mmu:619331); (R-MMU-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVG7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RUI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JII7-1", "uniprot_id": "ZFN2A_MOUSE", "mass": 19281.0, "length": 171, "protein_name": "AN1-type zinc finger protein 2A", "gene_name": "Zfand2a", "organism": "Mouse", "refseq_name": "AN1-type zinc finger protein 2A", "refseq_ac": "NP_001153380", "gene_names_uniprotkb": "Zfand2a; Airap", "gene_names_refseq": "Airap; Zfand2a", "protein_names_uniprotkb": "AN1-type zinc finger protein 2A; Arsenite-inducible RNA-associated protein", "protein_names_refseq": "AN1-type zinc finger protein 2A; arsenite inducible RNA associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:100494)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11525245;16973439;21750661;24898249;34572530", "class_list": "", "function": "AIRAP adapts the cell's core protein degradation machinery to counteract proteotoxicity induced by an environmental toxin., [RefSeq, PubMed]; An Arsenite Relay between PSMD14 and AIRAP Enables Revival of Proteasomal DUB Activity. Publication Status: Online-Only, [RefSeq, PubMed]; Arsenite- inducible regulatory particle-associated protein (AIRAP) transcript to be translationally induced during arsenite stress conditions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0000502 proteasome complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0045047 protein targeting to ER;GO:0071243 cellular response to arsenic-containing substance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JII7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07231-1", "uniprot_id": "ZSC21_MOUSE", "mass": 63012.0, "length": 555, "protein_name": "Zinc finger and SCAN domain-containing protein 21", "gene_name": "Zscan21", "organism": "Mouse", "refseq_name": "zinc finger and SCAN domain-containing protein 21", "refseq_ac": "NP_001038168", "gene_names_uniprotkb": "Zscan21; Zfp-38; Zfp38; Zipro1; Znf38", "gene_names_refseq": "CTfin51; RU49; Zfp-38; Zfp38; Zipro1; Zscan21", "protein_names_uniprotkb": "Zinc finger and SCAN domain-containing protein 21; CtFIN51; Transcription factor RU49; Zfp-38; Zinc finger protein 38", "protein_names_refseq": "transcription factor RU49; zinc finger and SCAN domain-containing protein 21; zinc finger proliferation 1; zinc finger protein 38", "tax_id": 10090, "disease": "", "pathway": " (mmu:22697)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1284028;1397691;21750661;27492080;8625807", "class_list": "", "function": "Strong transcriptional activator (PubMed:1284028). Plays an important role in spermatogenesis; essential for the progression of meiotic prophase I in spermatocytes (PubMed:27492080)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921V2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q07231-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02526-1", "uniprot_id": "ZFP41_MOUSE", "mass": 22724.0, "length": 198, "protein_name": "Zinc finger protein 41", "gene_name": "Zfp41", "organism": "Mouse", "refseq_name": "zinc finger protein 41", "refseq_ac": "NP_001038183", "gene_names_uniprotkb": "Zfp41; Zfp-41", "gene_names_refseq": "CTfin92; Zfp-41; Zfp41", "protein_names_uniprotkb": "Zinc finger protein 41; CtFIN92; Zfp-41", "protein_names_refseq": "zinc finger protein 41", "tax_id": 10090, "disease": "", "pathway": " (mmu:22701)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1397691;21750661", "class_list": "", "function": "A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSV7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q02526-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6IR37-1", "uniprot_id": "ZDH24_MOUSE", "mass": 30430.0, "length": 284, "protein_name": "Probable palmitoyltransferase ZDHHC24", "gene_name": "Zdhhc24", "organism": "Mouse", "refseq_name": "probable palmitoyltransferase ZDHHC24 isoform a", "refseq_ac": "NP_081752", "gene_names_uniprotkb": "Zdhhc24", "gene_names_refseq": "5730496N17Rik; Leng4; Zdhhc24", "protein_names_uniprotkb": "Probable palmitoyltransferase ZDHHC24; 2.3.1.225; Zinc finger DHHC domain-containing protein 24", "protein_names_refseq": "DHHC-24; leukocyte receptor cluster (LRC) member 4; probable palmitoyltransferase ZDHHC24 isoform a; probable palmitoyltransferase ZDHHC24; zinc finger DHHC domain-containing protein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:70605)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAY4;Q3TDF1;Q3TF09;Q9CS66", "ec_number_list": "2.3.1.225;6.3.1.2;2.3.1.-", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6IR37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10076-1", "uniprot_id": "ZFP26_MOUSE", "mass": 97989.0, "length": 861, "protein_name": "Zinc finger protein 26", "gene_name": "Zfp26", "organism": "Mouse", "refseq_name": "zinc finger protein 26 isoform a", "refseq_ac": "NP_035883", "gene_names_uniprotkb": "Zfp26; Kiaa4196; Mkr3; Zfp-26", "gene_names_refseq": "5033428C05Rik; KRAB15; Zfp-26; Zfp26; Zfp70; Zfp81-rs1; mKIAA4196; mkr-3; mszf14; mszf52", "protein_names_uniprotkb": "Zinc finger protein 26; Protein mKR3; Zfp-26", "protein_names_refseq": "protein mKR3; zinc finger protein 26 isoform a; zinc finger protein 81, related sequence 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22688)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;3143103", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]; May have a role during differentiation processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UR72;Q5DTI1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P10076-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5DTV4-1", "uniprot_id": "ZC12C_MOUSE", "mass": 99430.0, "length": 884, "protein_name": "Probable ribonuclease ZC3H12C", "gene_name": "Zc3h12c", "organism": "Mouse", "refseq_name": "probable ribonuclease ZC3H12C isoform 1", "refseq_ac": "NP_001156393", "gene_names_uniprotkb": "Zc3h12c; Kiaa1726", "gene_names_refseq": "A230108E06; C230027N18Rik; Zc3h12c; mKIAA1726", "protein_names_uniprotkb": "Probable ribonuclease ZC3H12C; 3.1.-.-; Zinc finger CCCH domain-containing protein 12C", "protein_names_refseq": "probable ribonuclease ZC3H12C isoform 1; probable ribonuclease ZC3H12C; regnase-3; zinc finger CCCH domain-containing protein 12C", "tax_id": 10090, "disease": "", "pathway": " (mmu:244871)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18178554;21750661;31126966;31219806;33157351;33950203;34215755;34298932", "class_list": "", "function": "Gfi1 and Zc3h12c orchestrate a negative feedback loop that inhibits NF-kB activation during inflammation in macrophages., [RefSeq, PubMed]; MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation., [RefSeq, PubMed]; May function as RNase and regulate the levels of target RNA species., [UniProtKB]; Molecular Mechanisms of ZC3H12C/Reg-3 Biological Activity and Its Involvement in Psoriasis Pathology. Publication Status: Online-Only, [RefSeq, PubMed]; PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases., [RefSeq, PubMed]; Required for immune homeostasis and regulation of the interferon pathway, [RefSeq, PubMed]; The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0004521 RNA endonuclease activity;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5DTV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q784-1", "uniprot_id": "ZC3HD_MOUSE", "mass": 203755.0, "length": 1729, "protein_name": "Zinc finger CCCH domain-containing protein 13", "gene_name": "Zc3h13", "organism": "Mouse", "refseq_name": "zinc finger CCCH domain-containing protein 13 isoform 2", "refseq_ac": "NP_080359", "gene_names_uniprotkb": "Zc3h13", "gene_names_refseq": "2600010B19Rik; 3110050K21Rik; 4930570G11Rik; Zc3h13", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 13", "protein_names_refseq": "zinc finger CCCH domain-containing protein 13 isoform 2; zinc finger CCCH domain-containing protein 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:67302)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "19131326;21183079;21750661;25605945;29535189;29547716;33649389;34428180;40885482;40997131", "class_list": "", "function": "Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (PubMed:29547716). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (PubMed:29547716). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (PubMed:29547716). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (PubMed:29535189)., [UniProtKB, PubMed, PubMed]; Identified Zc3h13 (zinc finger CCCH domain-containing protein 13)/Flacc [Fl(2)d-associated complex component] as a novel interactor of m(6)A methyltransferase complex components in Drosophila and mice, [RefSeq, PubMed]; Zc3h13 plays a critical role in anchoring WTAP, Virilizer, and Hakai in the nucleus to facilitate m(6)A methylation and to regulate murine embryonic stem cell self-renewal., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 46, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B9EHN9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:2000036 regulation of stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "E9Q784-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9Q8F8-1", "uniprot_id": "E9Q8F8_MOUSE", "mass": 192268.0, "length": 1683, "protein_name": "ATP-binding cassette, sub-family A member 14", "gene_name": "Abca14", "organism": "Mouse", "refseq_name": "ATP-binding cassette, sub-family A (ABC1), member 14", "refseq_ac": "NP_080734", "gene_names_uniprotkb": "Abca14", "gene_names_refseq": "1700110B15Rik; 4930539G24Rik; Abca14", "protein_names_uniprotkb": "ATP-binding cassette, sub-family A member 14", "protein_names_refseq": "ATP-binding cassette transporter sub-family A member 14; ATP-binding cassette, sub-family A (ABC1), member 14", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:67928)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31599954", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.1;7.6.2.-;7.6.2.2", "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9Q8F8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9QA94-1", "uniprot_id": "E9QA94_MOUSE", "mass": 34386.0, "length": 307, "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r129", "organism": "Mouse", "refseq_name": "vomeronasal 1 receptor 129", "refseq_ac": "NP_001160197", "gene_names_uniprotkb": "Vmn1r129", "gene_names_refseq": "EG621510; Gm6237; Vmn1r129", "protein_names_uniprotkb": "Vomeronasal type-1 receptor", "protein_names_refseq": "vomernasal 1 receptor Vmn1r129; vomeronasal 1 receptor 129", "tax_id": 10090, "disease": "", "pathway": " (mmu:621510)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9QA94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BIY3-1", "uniprot_id": "ZC12D_MOUSE", "mass": 59340.0, "length": 533, "protein_name": "Probable ribonuclease ZC3H12D", "gene_name": "Zc3h12d", "organism": "Mouse", "refseq_name": "probable ribonuclease ZC3H12D", "refseq_ac": "NP_766373", "gene_names_uniprotkb": "Zc3h12d; Mcpip4; Tfl", "gene_names_refseq": "D730019B10Rik; TFL; Zc3h12d", "protein_names_uniprotkb": "Probable ribonuclease ZC3H12D; 3.1.-.-; MCP-induced protein 4; Transformed follicular lymphoma homolog; Zinc finger CCCH domain-containing protein 12D", "protein_names_refseq": "probable ribonuclease ZC3H12D; transformed follicular lymphoma homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:237256)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "18178554;21750661;22036805;24415781;26059755;26134560;34428180;37304286;38697601", "class_list": "", "function": "MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation., [RefSeq, PubMed]; May regulate cell growth likely by suppressing RB1 phosphorylation (By similarity). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (By similarity). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (By similarity)., [UniProtKB, UniProtKB, PubMed]; TFL (Zc3h12d) may play an important role in attenuating local inflammation by suppressing the infiltration of Th17 cells in the central nervous system during the resolution phase of experimental autoimmune encephalitis., [RefSeq, PubMed]; Tfl deletion induces extraordinary Cxcl13 secretion and cachexia in VavP-Bcl2 transgenic mice. Publication Status: Online-Only, [RefSeq, PubMed]; The data indicated that ZC3H12D could suppress both the initial inflammation storm and chronic inflammation by targeting the mRNA of cytokines as well as NF-kappaB and c-fos., [RefSeq, PubMed]; The role of ZC3H12D-regulated TLR4-NF-kappaB pathway in LPS-induced pro-inflammatory microglial activation., [RefSeq, PubMed]; Zc3h12d is a novel negative feedback regulator of TLR signaling and macrophage activation and thus may play a role in host immunity and inflammatory diseases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FU74", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0004521 RNA endonuclease activity;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0042130 negative regulation of T cell proliferation;GO:0030308 negative regulation of cell growth;GO:0006402 mRNA catabolic process;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle;GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BIY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3U5F4-1", "uniprot_id": "YRDC_MOUSE", "mass": 29454.0, "length": 280, "protein_name": "Threonylcarbamoyl-AMP synthase", "gene_name": "Yrdc", "organism": "Mouse", "refseq_name": "threonylcarbamoyl-AMP synthase precursor", "refseq_ac": "NP_705794", "gene_names_uniprotkb": "Yrdc; Irip", "gene_names_refseq": "IRIP; ITIP; Yrdc", "protein_names_uniprotkb": "Threonylcarbamoyl-AMP synthase; 2.7.7.87; Ischemia/reperfusion-inducible protein; mIRIP", "protein_names_refseq": "Ischemia/reperfusion-inducible protein; mIRIP; threonylcarbamoyl-AMP synthase precursor; threonylcarbamoyl-AMP synthase; yrdC domain-containing protein, mitochondrial", "tax_id": 10090, "disease": "Galloway-Mowat syndrome (Disease Ontology:DOID:0080694)", "pathway": " (mmu:230734); (R-MMU-6787450)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16024787;21750661;24129315;25153642;35820727", "class_list": "", "function": "Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs (By similarity). May regulate the activity of some transporters (PubMed:16024787)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1ARW9;B1ARX2;Q7TSY0;Q8CII1", "ec_number_list": "2.7.7.87", "go_molecular_function": "GO:0000049 tRNA binding;GO:0003725 double-stranded RNA binding;GO:0016779 nucleotidyltransferase activity;GO:0061710 L-threonylcarbamoyladenylate synthase", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002949 tRNA threonylcarbamoyladenosine modification;GO:0051051 negative regulation of transport;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3U5F4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JJN2-1", "uniprot_id": "ZFHX4_MOUSE", "mass": 392323.0, "length": 3550, "protein_name": "Zinc finger homeobox protein 4", "gene_name": "Zfhx4", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zfhx4; Zfh4", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger homeobox protein 4; ZFH-4; Zinc finger homeodomain protein 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "spinocerebellar ataxia 4 (Disease Ontology:DOID:0050957); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "10873665;16946494;21750661;25428506;28011936;30084848;34428180", "class_list": "", "function": "May play a role in neural and muscle differentiation. May be involved in transcriptional regulation., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JJN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3URS2-1", "uniprot_id": "ZSC4F_MOUSE", "mass": 57648.0, "length": 506, "protein_name": "Zinc finger and SCAN domain containing protein 4F", "gene_name": "Zscan4f", "organism": "Mouse", "refseq_name": "zinc finger and SCAN domain containing protein 4F", "refseq_ac": "NP_001103786", "gene_names_uniprotkb": "Zscan4f", "gene_names_refseq": "C330039H09Rik; Zscan4f", "protein_names_uniprotkb": "Zinc finger and SCAN domain containing protein 4F", "protein_names_refseq": "zinc finger and SCAN domain containing protein 4F", "tax_id": 10090, "disease": "", "pathway": " (mmu:665902)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17553482;21750661;23147797", "class_list": "", "function": "Transcription factor required to regulate early development. Binds telomeres and plays a key role in genomic stability by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation (By similarity)., [UniProtKB]; Zscan4f, in combination with the Yamanaka factors, not only remarkably reduced the DDR but also markedly promoted the efficiency of iPS cell generation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3URS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M0QWD8-1", "uniprot_id": "M0QWD8_MOUSE", "mass": 10041.0, "length": 85, "protein_name": "Predicted gene 10267", "gene_name": "Gm10267", "organism": "Mouse", "refseq_name": "vitellogenin-like 1", "refseq_ac": "NP_001268399", "gene_names_uniprotkb": "Gm10267", "gene_names_refseq": "Gm10267; Vtlgl1", "protein_names_uniprotkb": "Predicted gene 10267", "protein_names_refseq": "vitellogenin-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:100042855)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0QWD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08043-1", "uniprot_id": "ZFP2_MOUSE", "mass": 52534.0, "length": 459, "protein_name": "Zinc finger protein ZFP2", "gene_name": "Zfp2", "organism": "Mouse", "refseq_name": "zinc finger protein ZFP2", "refseq_ac": "NP_001038162", "gene_names_uniprotkb": "Zfp2; Fnp-2; Mkr2; Zfp-2", "gene_names_refseq": "9930007F06Rik; Fnp-2; Zfp-2; Zfp2; mKR2; mkr-2; mszf87", "protein_names_uniprotkb": "Zinc finger protein ZFP2; Protein mKR2; Zfp-2", "protein_names_refseq": "zinc finger protein ZFP2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22678)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11471062;3409867;3815523", "class_list": "", "function": "Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V280;Q8R012", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P08043-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10077-1", "uniprot_id": "ZFP27_MOUSE", "mass": 92894.0, "length": 819, "protein_name": "Zinc finger protein 27", "gene_name": "Zfp27", "organism": "Mouse", "refseq_name": "zinc finger protein 27 isoform 1", "refseq_ac": "NP_001032796", "gene_names_uniprotkb": "Zfp27; Mkr4; Zfp-27", "gene_names_refseq": "Zfp-27; Zfp27; mkr-4; mszf76", "protein_names_uniprotkb": "Zinc finger protein 27; Protein mKR4; Zfp-27", "protein_names_refseq": "protein mKR4; zinc finger protein 27 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22689); (R-MMU-212436)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "31219806;3143103;34428180;37668106", "class_list": "", "function": "Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease., [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCZ6;Q8CED4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P10077-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P59267-1", "uniprot_id": "ZDHC2_MOUSE", "mass": 41982.0, "length": 366, "protein_name": "Palmitoyltransferase ZDHHC2", "gene_name": "Zdhhc2", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC2 isoform 1", "refseq_ac": "NP_848482", "gene_names_uniprotkb": "Zdhhc2", "gene_names_refseq": "5730415P04Rik; 6430583A19Rik; DHHC-2; Zdhhc2", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC2; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC2; DHHC-2; Zinc finger DHHC domain-containing protein 2", "protein_names_refseq": "acyltransferase ZDHHC2; palmitoyltransferase ZDHHC2 isoform 1; palmitoyltransferase ZDHHC2; zinc finger DHHC domain-containing protein 2", "tax_id": 10090, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (mmu:70546); (R-MMU-5683826)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "15603741;21343290;21471008;25428506;25589740;28167757;28768144;30084848;32587588;33488612;33725478;34428180", "class_list": "", "function": "In vivo Screen Identifies Zdhhc2 as a Critical Regulator of Germinal Center B Cell Differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:15603741). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (PubMed:25589740). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (PubMed:15603741). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (PubMed:21343290). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function. Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane. Could also palmitoylate LCK and regulate its localization to the plasma membrane (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.225;6.3.1.2;2.3.1.-", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098837 postsynaptic recycling endosome;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1903539 protein localization to postsynaptic membrane;GO:0072659 protein localization to plasma membrane;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0006612 protein targeting to membrane;GO:0022407 regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P59267-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02525-1", "uniprot_id": "ZFP39_MOUSE", "mass": 84223.0, "length": 718, "protein_name": "Zinc finger protein 39", "gene_name": "Zfp39", "organism": "Mouse", "refseq_name": "zinc finger protein 39", "refseq_ac": "NP_035888", "gene_names_uniprotkb": "Zfp39; Zfp-39", "gene_names_refseq": "CTfin33; Zfp-39; Zfp39", "protein_names_uniprotkb": "Zinc finger protein 39; CtFIN33; Zfp-39", "protein_names_refseq": "zinc finger protein 39", "tax_id": 10090, "disease": "", "pathway": " (mmu:22698); (R-MMU-212436)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1397691;31219806", "class_list": "", "function": "A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2YDX7;Q5NC60;Q8BL91", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q02525-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TIV5-1", "uniprot_id": "ZC3HF_MOUSE", "mass": 48327.0, "length": 426, "protein_name": "Zinc finger CCCH domain-containing protein 15", "gene_name": "Zc3h15", "organism": "Mouse", "refseq_name": "zinc finger CCCH domain-containing protein 15", "refseq_ac": "NP_081210", "gene_names_uniprotkb": "Zc3h15; Dfrp1", "gene_names_refseq": "1700006A17Rik; 1810012H02Rik; 2610312B22Rik; FM22; Ierepo4; Zc3h15", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 15; DRG family-regulatory protein 1; Epo-immediate response gene protein FM22", "protein_names_refseq": "DRG family-regulatory protein 1; epo-immediate response gene protein FM22; zinc finger CCCH domain-containing protein 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:69082); (R-MMU-9629569)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10880228;15676025;25428506;30084848;30779550;31219806;31599954;34428180;37828378", "class_list": "", "function": "Protects DRG1 from proteolytic degradation (PubMed:15676025). Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWQ0;Q3U855;Q8K2B6;Q8K346;Q9CVM4;Q9DAP2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0019221 cytokine-mediated signaling pathway;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3TIV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3TXZ1-1", "uniprot_id": "ZN575_MOUSE", "mass": 26282.0, "length": 239, "protein_name": "Zinc finger protein 575", "gene_name": "Znf575", "organism": "Mouse", "refseq_name": "zinc finger protein 575", "refseq_ac": "NP_001028377", "gene_names_uniprotkb": "Znf575; Zfp575", "gene_names_refseq": "Zfp575; Znf575", "protein_names_uniprotkb": "Zinc finger protein 575", "protein_names_refseq": "zinc finger protein 575", "tax_id": 10090, "disease": "", "pathway": " (mmu:101544)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "37305392", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]; The zinc figure protein ZNF575 impairs colorectal cancer growth via promoting p53 transcription. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3TXZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q497H0-1", "uniprot_id": "ZFAN3_MOUSE", "mass": 25081.0, "length": 227, "protein_name": "AN1-type zinc finger protein 3", "gene_name": "Zfand3", "organism": "Mouse", "refseq_name": "AN1-type zinc finger protein 3 isoform 1", "refseq_ac": "NP_683728", "gene_names_uniprotkb": "Zfand3; Tex27", "gene_names_refseq": "TEG-27; Tex27; Zfand3", "protein_names_uniprotkb": "AN1-type zinc finger protein 3; Testis-expressed protein 27", "protein_names_refseq": "AN1-type zinc finger protein 3 isoform 1; AN1-type zinc finger protein 3; testis-expressed protein 27", "tax_id": 10090, "disease": "", "pathway": " (mmu:21769)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10366431;21750661;34428180;8703127", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K230;Q8R2V7;Q8R3V1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q497H0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5HZG9-1", "uniprot_id": "ZN488_MOUSE", "mass": 37195.0, "length": 337, "protein_name": "Zinc finger protein 488", "gene_name": "Znf488", "organism": "Mouse", "refseq_name": "zinc finger protein 488", "refseq_ac": "NP_001013799", "gene_names_uniprotkb": "Znf488; Gm1206; Zfp488", "gene_names_refseq": "Gm1206; Zfp488; Znf488", "protein_names_uniprotkb": "Zinc finger protein 488", "protein_names_refseq": "zinc finger protein 488", "tax_id": 10090, "disease": "", "pathway": " (mmu:382867)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16908628;22355521;38546197", "class_list": "", "function": "The myelination-associated G protein-coupled receptor 37 is regulated by Zfp488, Nkx2.2, and Sox10 during oligodendrocyte differentiation., [RefSeq, PubMed]; Transcriptional repressor (PubMed:16908628). Plays a role in oligodendrocyte differentiation, together with OLIG2 (PubMed:16908628, PubMed:22355521). Mediates Notch signaling-activated formation of oligodendrocyte precursors (PubMed:16908628). Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury (PubMed:22355521)., [UniProtKB, PubMed, PubMed]; Zfp488 functions as an oligodendrocyte-specific transcription co-regulator important for oligodendrocyte maturation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0006355 regulation of DNA-templated transcription;GO:0014003 oligodendrocyte development;GO:0031643 positive regulation of myelination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5HZG9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5Y5T3-1", "uniprot_id": "ZDH23_MOUSE", "mass": 48150.0, "length": 425, "protein_name": "Palmitoyltransferase ZDHHC23", "gene_name": "Zdhhc23", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC23", "refseq_ac": "NP_001007461", "gene_names_uniprotkb": "Zdhhc23; Gm779", "gene_names_refseq": "DHHC-23; Gm1751; Gm779; Zdhhc23; nidd", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC23; 2.3.1.225; DHHC-23; DHHC-containing protein 11; Zinc finger DHHC domain-containing protein 23; zDHHC23", "protein_names_refseq": "DHHC-containing protein 11; nNOS-intereacting DHHC-containing Dem protein-L; palmitoyltransferase ZDHHC23; probable palmitoyltransferase ZDHHC23; zinc finger DHHC domain-containing protein 23", "tax_id": 10090, "disease": "", "pathway": " (mmu:332175)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15603741", "class_list": "", "function": "Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes. Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H5Y4;Q3UH65;Q3UVA2", "ec_number_list": "2.3.1.225;6.3.1.2;2.3.1.-", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006612 protein targeting to membrane;GO:0018345 protein palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5Y5T3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q62396-1", "uniprot_id": "ZFP92_MOUSE", "mass": 55976.0, "length": 488, "protein_name": "Zinc finger protein 92", "gene_name": "Zfp92", "organism": "Mouse", "refseq_name": "zinc finger protein 92 isoform 1", "refseq_ac": "NP_033592", "gene_names_uniprotkb": "Zfp92", "gene_names_refseq": "Zfp92", "protein_names_uniprotkb": "Zinc finger protein 92; Zfp-92", "protein_names_refseq": "zfp-92; zinc finger protein 92 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22754)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22872234;25428506;25605945;30084848;37155670;8828036", "class_list": "", "function": "KRAB domain-containing zinc-finger protein that represses B1/Alu SINE transposable elements and modulates the transcription of nearby genes in a tissue-specific manner. It regulates glucose homeostasis and lipid metabolism by modulating the expression of the endocrine cell-defining transcription factor, MAFB, in pancreatic islets and, the fat metabolism regulator, ACACB, in adipose tissue and muscle., [UniProtKB, PubMed]; ZFP92, a KRAB domain zinc finger protein enriched in pancreatic islets, binds to B1/Alu SINE transposable elements and regulates retroelements and genes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJR0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010906 regulation of glucose metabolic process;GO:0019216 regulation of lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62396-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6V5K9-1", "uniprot_id": "ZN474_MOUSE", "mass": 38134.0, "length": 347, "protein_name": "Zinc finger protein 474", "gene_name": "Znf474", "organism": "Mouse", "refseq_name": "zinc finger protein 474", "refseq_ac": "NP_080025", "gene_names_uniprotkb": "Znf474; Zfp474", "gene_names_refseq": "4933409D10Rik; Zfp474; Znf474", "protein_names_uniprotkb": "Zinc finger protein 474; TSZFP; Testis-specific zinc finger protein", "protein_names_refseq": "TSZFP; testis-specific zinc finger protein; zinc finger protein 474", "tax_id": 10090, "disease": "", "pathway": " (mmu:66758)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17971504", "class_list": "", "function": "Zfp474 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D472;Q9D985", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6V5K9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7TS63-1", "uniprot_id": "ZFAT_MOUSE", "mass": 137883.0, "length": 1237, "protein_name": "Zinc finger protein ZFAT", "gene_name": "Zfat", "organism": "Mouse", "refseq_name": "zinc finger protein ZFAT isoform 1", "refseq_ac": "NP_001139360", "gene_names_uniprotkb": "Zfat; Gm922; Zfat1; Zfp406; Znf406", "gene_names_refseq": "Gm922; Zfat1; Zfat; Zfp406", "protein_names_uniprotkb": "Zinc finger protein ZFAT; Zinc finger protein 406", "protein_names_refseq": "ZFAT zinc finger 1; zinc finger protein 403; zinc finger protein 406; zinc finger protein ZFAT isoform 1; zinc finger protein ZFAT", "tax_id": 10090, "disease": "autoimmune thyroiditis (Disease Ontology:DOID:7188)", "pathway": " (mmu:380993)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "18329245;20660741;21225468;21750661;25801860;31219806;31366551;32997115;34428180;34547289;36210013", "class_list": "", "function": "CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA., [RefSeq, PubMed]; May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Study shows that ZFAT protein is expressed in B and T lymphocytes in mouse and that ZFAT regulates immune-related genes functionally important for immune responsiveness., [RefSeq, PubMed]; ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B-H4K8ac-BRD4 axis., [RefSeq, PubMed]; ZFAT is a critical molecule for cell survival in MEFs and MOLT-4 cells at least in part through the regulation of the apoptosis involved in the BCL-2- and IL6st-mediated pathways., [RefSeq, PubMed]; ZFAT is indispensable for mouse embryonic development and functions as a critical transcription factor for primitive hematopoiesis through direct-regulation of Tal1, Lmo2, and Gata1, [RefSeq, PubMed]; Zfat knockdown partially inhibited CD71(-/low)Ter119(-) to CD71(high)Ter119(-) transition of fetal liver erythroid progenitors with impairment in the elevation of CD71 expression. Zfat plays a critical role for erythropoiesis in the fetal liver, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2C322", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0030097 hemopoiesis;GO:0060712 spongiotrophoblast layer development;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7TS63-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80TC6-1", "uniprot_id": "ZSWM5_MOUSE", "mass": 130927.0, "length": 1188, "protein_name": "Zinc finger SWIM domain-containing protein 5", "gene_name": "Zswim5", "organism": "Mouse", "refseq_name": "zinc finger SWIM domain-containing protein 5", "refseq_ac": "NP_001025083", "gene_names_uniprotkb": "Zswim5; Kiaa1511", "gene_names_refseq": "4933426E21Rik; Zswim5; mKIAA1511", "protein_names_uniprotkb": "Zinc finger SWIM domain-containing protein 5", "protein_names_refseq": "zinc finger SWIM domain-containing protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:74464)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "25428506;30084848;30779550;31219806;31599954;32144752;35820727", "class_list": "", "function": "Developmental characterization of Zswim5 expression in the progenitor domains and tangential migration pathways of cortical interneurons in the mouse forebrain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q80TC6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80VJ6-1", "uniprot_id": "ZSC4C_MOUSE", "mass": 57600.0, "length": 506, "protein_name": "Zinc finger and SCAN domain containing protein 4C", "gene_name": "Zscan4c", "organism": "Mouse", "refseq_name": "zinc finger and SCAN domain containing protein 4C", "refseq_ac": "NP_001013787", "gene_names_uniprotkb": "Zscan4c; Gm397", "gene_names_refseq": "Gm397; XM_142517; Zscan4c; Zscan4d", "protein_names_uniprotkb": "Zinc finger and SCAN domain containing protein 4C", "protein_names_refseq": "zinc finger and SCAN domain containing protein 4C", "tax_id": 10090, "disease": "", "pathway": " (mmu:245109)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16971461;17553482;19350676;20336070;31304534", "class_list": "", "function": "Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells., [UniProtKB, PubMed, PubMed, PubMed]; The importance of Zscan4c in regulation of embryonic stem cell pluripotency, [RefSeq, PubMed]; Zscan4 is involved in telomere maintenance and long-term genomic stability in ES cells, [RefSeq, PubMed]; Zscan4c activates endogenous retrovirus transposable elements and cleavage embryo genes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation;GO:0045950 negative regulation of mitotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80VJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80YP6-1", "uniprot_id": "ZIK1_MOUSE", "mass": 52727.0, "length": 463, "protein_name": "Zinc finger protein interacting with ribonucleoprotein K", "gene_name": "Zik1", "organism": "Mouse", "refseq_name": "zinc finger protein interacting with ribonucleoprotein K isoform 1", "refseq_ac": "NP_033603", "gene_names_uniprotkb": "Zik1", "gene_names_refseq": "Zik1", "protein_names_uniprotkb": "Zinc finger protein interacting with ribonucleoprotein K", "protein_names_refseq": "zinc finger protein interacting with ribonucleoprotein K isoform 1; zinc finger protein interacting with ribonucleoprotein K", "tax_id": 10090, "disease": "", "pathway": " (mmu:22775); (R-MMU-212436)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19777566;8910362", "class_list": "", "function": "Data indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa., [RefSeq, PubMed]; May be a transcriptional repressor., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70405", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80YP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q80ZJ6-1", "uniprot_id": "ZER1_MOUSE", "mass": 89076.0, "length": 779, "protein_name": "Protein zer-1 homolog", "gene_name": "Zer1", "organism": "Mouse", "refseq_name": "protein zer-1 homolog isoform b", "refseq_ac": "NP_001277432", "gene_names_uniprotkb": "Zer1; Zyg11bl; Zyg", "gene_names_refseq": "C230075L19Rik; Zer1; Zyg11bl", "protein_names_uniprotkb": "Protein zer-1 homolog; Zyg-11 homolog B-like protein", "protein_names_refseq": "protein zer-1 homolog isoform b; protein zer-1 homolog; zyg-11 homolog B-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:227693)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25428506;30084848;34203471;34428180;36210013", "class_list": "", "function": "Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redundantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BEA2;Q6PGH5;Q8BG38", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80ZJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BI99-1", "uniprot_id": "ZN879_MOUSE", "mass": 64066.0, "length": 563, "protein_name": "Zinc finger protein 879", "gene_name": "Znf879", "organism": "Mouse", "refseq_name": "zinc finger protein 879 isoform 2", "refseq_ac": "NP_001277708", "gene_names_uniprotkb": "Znf879; Zfp879", "gene_names_refseq": "Zfp879; Znf879", "protein_names_uniprotkb": "Zinc finger protein 879", "protein_names_refseq": "novel zinc finger protein; zinc finger protein 879 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:214779)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25428506;36852467", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BI99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BLB0-1", "uniprot_id": "ZFP3_MOUSE", "mass": 56574.0, "length": 497, "protein_name": "Zinc finger protein 3", "gene_name": "Zfp3", "organism": "Mouse", "refseq_name": "zinc finger protein 3", "refseq_ac": "NP_808233", "gene_names_uniprotkb": "Zfp3", "gene_names_refseq": "B230309J24; Fnp-1; Zfp-3; Zfp3", "protein_names_uniprotkb": "Zinc finger protein 3; Zfp-3", "protein_names_refseq": "zinc finger protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:193043)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15889621;34428180", "class_list": "", "function": "AI854635 is a novel exercise-related gene involved in myoblast differentiation, [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BLB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8BYK8-1", "uniprot_id": "ZC3H6_MOUSE", "mass": 131250.0, "length": 1177, "protein_name": "Zinc finger CCCH domain-containing protein 6", "gene_name": "Zc3h6", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zc3h6; Zc3hdc6", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 6", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:78751)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34203471", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AP87;Q80UK3;Q8C1H1;Q9D604", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BYK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8CFL8-1", "uniprot_id": "ZSWM3_MOUSE", "mass": 79132.0, "length": 695, "protein_name": "Zinc finger SWIM domain-containing protein 3", "gene_name": "Zswim3", "organism": "Mouse", "refseq_name": "zinc finger SWIM domain-containing protein 3", "refseq_ac": "NP_848462", "gene_names_uniprotkb": "Zswim3", "gene_names_refseq": "4921517A06Rik; Zswim3", "protein_names_uniprotkb": "Zinc finger SWIM domain-containing protein 3", "protein_names_refseq": "zinc finger SWIM domain-containing protein 3; zinc finger, SWIM domain containing 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:67538)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22872234;25428507;25605945;30084848;32639005;34428180", "class_list": "", "function": "DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-kappaB pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CFL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VC90-1", "uniprot_id": "ZDH12_MOUSE", "mass": 30708.0, "length": 267, "protein_name": "Palmitoyltransferase ZDHHC12", "gene_name": "Zdhhc12", "organism": "Mouse", "refseq_name": "palmitoyltransferase ZDHHC12 isoform b", "refseq_ac": "NP_001032851", "gene_names_uniprotkb": "Zdhhc12", "gene_names_refseq": "1190004A01Rik; Zdhhc12", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC12; 2.3.1.225; DHHC domain-containing cysteine-rich protein 12; DHHC-12; Zinc finger DHHC domain-containing protein 12", "protein_names_refseq": "DHHC domain-containing cysteine-rich protein 12; DHHC-12; palmitoyltransferase ZDHHC12 isoform b; probable palmitoyltransferase ZDHHC12; zinc finger DHHC domain-containing protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:66220)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25025157;31219806;36586411", "class_list": "", "function": "Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy., [RefSeq, PubMed]; Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:25025157). Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering (PubMed:25025157). Thereby, indirectly regulates GABAergic synaptic transmission (PubMed:25025157). Negatively regulates NLRP3-driven inflammation. Catalyzes NLRP3 palmitoylation, leading to its degradation via the chaperone-mediated autophagy (CMA) process., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZ24;Q9D0T6", "ec_number_list": "2.3.1.225;6.3.1.2;2.3.1.-", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0043197 dendritic spine", "go_biological_process": "GO:0097112 gamma-aminobutyric acid receptor clustering;GO:0097116 gephyrin clustering involved in postsynaptic density assembly;GO:0061684 chaperone-mediated autophagy;GO:0006612 protein targeting to membrane;GO:0032230 positive regulation of synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VC90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8VCZ7-1", "uniprot_id": "ZBT7C_MOUSE", "mass": 69086.0, "length": 619, "protein_name": "Zinc finger and BTB domain-containing protein 7C", "gene_name": "Zbtb7c", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 7C", "refseq_ac": "NP_663331", "gene_names_uniprotkb": "Zbtb7c; Zbtb36", "gene_names_refseq": "B230208J24Rik; Kr-pok; Zbtb36; Zbtb7c", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 7C; Zinc finger and BTB domain-containing protein 36", "protein_names_refseq": "zinc finger and BTB domain containing 36; zinc finger and BTB domain-containing protein 36; zinc finger and BTB domain-containing protein 7C", "tax_id": 10090, "disease": "", "pathway": " (mmu:207259)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "31222731;31599954;34017061;34428180", "class_list": "", "function": "May be a tumor suppressor gene., [UniProtKB]; Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity., [RefSeq, PubMed]; Zbtb7c degradation or absence may contribute to the pathogenesis of emphysema, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045600 positive regulation of fat cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VCZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9D534-1", "uniprot_id": "ZC21B_MOUSE", "mass": 19689.0, "length": 172, "protein_name": "Zinc finger C2HC domain-containing protein 1B", "gene_name": "Zc2hc1b", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Zc2hc1b; Fam164b", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger C2HC domain-containing protein 1B", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "30059200", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D534-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ERR8-1", "uniprot_id": "ZN319_MOUSE", "mass": 65644.0, "length": 581, "protein_name": "Zinc finger protein 319", "gene_name": "Znf319", "organism": "Mouse", "refseq_name": "zinc finger protein 319", "refseq_ac": "NP_077787", "gene_names_uniprotkb": "Znf319; Zfp319", "gene_names_refseq": "Zfp319; Znf319; mKIAA1388", "protein_names_uniprotkb": "Zinc finger protein 319", "protein_names_refseq": "zinc finger protein 319", "tax_id": 10090, "disease": "", "pathway": " (mmu:79233)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11161788", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ERR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9JKN1-1", "uniprot_id": "ZNT7_MOUSE", "mass": 41790.0, "length": 378, "protein_name": "Zinc transporter 7", "gene_name": "Slc30a7", "organism": "Mouse", "refseq_name": "zinc transporter 7", "refseq_ac": "NP_075703", "gene_names_uniprotkb": "Slc30a7; Znt7; Zntl2", "gene_names_refseq": "1810059J10Rik; 2610034N15Rik; 4833428C12Rik; Slc30a7; ZnT-7; ZnT7; Zntl2", "protein_names_uniprotkb": "Zinc transporter 7; Solute carrier family 30 member 7; Znt-like transporter 2", "protein_names_refseq": "solute carrier family 30 member 7; zinc transporter 7; znt-like transporter 2", "tax_id": 10090, "disease": "carcinoma (Disease Ontology:DOID:305)", "pathway": " (mmu:66500)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12446736;16636052;17101726;17954933;19283665;20173027;30084848;34428180;37553324", "class_list": "", "function": "Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn[2+] uptake into the Golgi apparatus. Publication Status: Online-Only, [RefSeq, PubMed]; Novel member of zinc transporter family that accumulates zinc in the Golgi apparatus, [RefSeq, PubMed]; Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway (PubMed:12446736, PubMed:17954933). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; ZnT5(-)ZnT7(-/-) cells showed exacerbation of the unfolded protein response as did the wild-type cells cultured under a zinc-deficient condition, revealing that both complexes play a role in homeostatic maintenance of secretory pathway function, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80Y27", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006829 zinc ion transport;GO:0006882 intracellular zinc ion homeostasis;GO:1904257 zinc ion import into Golgi lumen", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JKN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A075B5V1-1", "uniprot_id": "A0A075B5V1_MOUSE", "mass": 10966.0, "length": 98, "protein_name": "Immunoglobulin heavy variable 1-31", "gene_name": "Ighv1-31", "organism": "Mouse", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Ighv1-31", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy variable 1-31", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-173623); 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